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Aliases for CSNK1A1L Gene

Aliases for CSNK1A1L Gene

  • Casein Kinase 1 Alpha 1 Like 2 3 5
  • CKI-Alpha-Like 3 4
  • EC 2.7.11.1 4 58
  • CK1 3 4
  • Casein Kinase I Isoform Alpha-Like 3
  • Casein Kinase 1, Alpha 1-Like 2
  • Casein Kinase I Alpha S-Like 3
  • EC 2.7.11 58

External Ids for CSNK1A1L Gene

Previous GeneCards Identifiers for CSNK1A1L Gene

  • GC13M035476
  • GC13M036575
  • GC13M037677
  • GC13M018489

Summaries for CSNK1A1L Gene

GeneCards Summary for CSNK1A1L Gene

CSNK1A1L (Casein Kinase 1 Alpha 1 Like) is a Protein Coding gene. Among its related pathways are Hedgehog Pathway and Endometrial cancer. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CSNK1A1.

UniProtKB/Swiss-Prot for CSNK1A1L Gene

  • Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity).

Additional gene information for CSNK1A1L Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSNK1A1L Gene

Genomics for CSNK1A1L Gene

Regulatory Elements for CSNK1A1L Gene

Enhancers for CSNK1A1L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13H037107 0.6 ENCODE 47.5 -3.1 -3143 2 CTCF ZNF654 REST ATF2 RAD21 ZNF143 SMC3 FOS CSNK1A1L ENSG00000274549
GH13H036997 1.4 ENCODE dbSUPER 7 +105.6 105582 4 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF207 SUPT20H EXOSC8 RFXAP SPART-AS1 ALG5 SMAD9 CSNK1A1L
GH13H037100 0.4 ENCODE 23 +4.4 4423 1 CEBPA CSNK1A1L SUPT20H
GH13H037149 0.3 FANTOM5 20.7 -43.9 -43874 0 CSNK1A1L EXOSC8 SUPT20H ENSG00000279511 RN7SKP1 GC13M037167
GH13H037133 1 Ensembl ENCODE 5.4 -29.5 -29526 3 JUN FEZF1 ZNF843 ZBTB40 OSR2 MAFF JUND PRDM6 GLIS1 SCRT2 SUPT20H CSNK1A1L ENSG00000274549
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CSNK1A1L on UCSC Golden Path with GeneCards custom track

Genomic Location for CSNK1A1L Gene

Chromosome:
13
Start:
37,103,259 bp from pter
End:
37,105,664 bp from pter
Size:
2,406 bases
Orientation:
Minus strand

Genomic View for CSNK1A1L Gene

Genes around CSNK1A1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CSNK1A1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CSNK1A1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSNK1A1L Gene

Proteins for CSNK1A1L Gene

  • Protein details for CSNK1A1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N752-KC1AL_HUMAN
    Recommended name:
    Casein kinase I isoform alpha-like
    Protein Accession:
    Q8N752
    Secondary Accessions:
    • Q5T2N2

    Protein attributes for CSNK1A1L Gene

    Size:
    337 amino acids
    Molecular mass:
    39086 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CSNK1A1L Gene

Selected DME Specific Peptides for CSNK1A1L Gene

Q8N752:
  • QGGVGIP
  • HRDIKPDN
  • KYEKISEKK
  • DWTMLKQK
  • RKIGSGSFG
  • FLHRDIK
  • WYGQEKD
  • HPQLLYESKLY
  • RDIKPDNFL
  • PDNFLMG
  • LADQMISRI
  • YLRQLFR
  • LLGPSLEDLF
  • MYFNRTSLPWQGL
  • DFGLAKKYRD
  • GIEQSRRDD
  • VAVKLESQK

Post-translational modifications for CSNK1A1L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CSNK1A1L Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for CSNK1A1L Gene

Gene Families for CSNK1A1L Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for CSNK1A1L Gene

Suggested Antigen Peptide Sequences for CSNK1A1L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N752

UniProtKB/Swiss-Prot:

KC1AL_HUMAN :
  • Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
Family:
  • Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
genes like me logo Genes that share domains with CSNK1A1L: view

Function for CSNK1A1L Gene

Molecular function for CSNK1A1L Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity).

Enzyme Numbers (IUBMB) for CSNK1A1L Gene

Phenotypes From GWAS Catalog for CSNK1A1L Gene

Gene Ontology (GO) - Molecular Function for CSNK1A1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IBA --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with CSNK1A1L: view
genes like me logo Genes that share phenotypes with CSNK1A1L: view

Animal Model Products

CRISPR Products

miRNA for CSNK1A1L Gene

miRTarBase miRNAs that target CSNK1A1L

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CSNK1A1L
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CSNK1A1L Gene

Localization for CSNK1A1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSNK1A1L Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CSNK1A1L gene
Compartment Confidence
cytosol 5
nucleus 4
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CSNK1A1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with CSNK1A1L: view

Pathways & Interactions for CSNK1A1L Gene

genes like me logo Genes that share pathways with CSNK1A1L: view

Pathways by source for CSNK1A1L Gene

1 GeneGo (Thomson Reuters) pathway for CSNK1A1L Gene

SIGNOR curated interactions for CSNK1A1L Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for CSNK1A1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0006909 phagocytosis IBA --
GO:0008360 regulation of cell shape IBA --
GO:0016055 Wnt signaling pathway IBA --
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with CSNK1A1L: view

Drugs & Compounds for CSNK1A1L Gene

(7) Drugs for CSNK1A1L Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for CSNK1A1L Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CSNK1A1L: view

Transcripts for CSNK1A1L Gene

mRNA/cDNA for CSNK1A1L Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CSNK1A1L Gene

Casein kinase 1, alpha 1-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CSNK1A1L
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for CSNK1A1L Gene

No ASD Table

Relevant External Links for CSNK1A1L Gene

GeneLoc Exon Structure for
CSNK1A1L
ECgene alternative splicing isoforms for
CSNK1A1L

Expression for CSNK1A1L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CSNK1A1L Gene

mRNA differential expression in normal tissues according to GTEx for CSNK1A1L Gene

This gene is overexpressed in Testis (x25.1) and Whole Blood (x17.1).

Protein differential expression in normal tissues from HIPED for CSNK1A1L Gene

This gene is overexpressed in Cervix (44.2) and Heart (24.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CSNK1A1L Gene



Protein tissue co-expression partners for CSNK1A1L Gene

NURSA nuclear receptor signaling pathways regulating expression of CSNK1A1L Gene:

CSNK1A1L

SOURCE GeneReport for Unigene cluster for CSNK1A1L Gene:

Hs.512897
genes like me logo Genes that share expression patterns with CSNK1A1L: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CSNK1A1L Gene

Orthologs for CSNK1A1L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CSNK1A1L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CSNK1A1L 33 34
  • 99.6 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 95 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Csnk1a1 34
  • 92 (a)
OneToMany
cow
(Bos Taurus)
Mammalia CSNK1A1 34
  • 90 (a)
ManyToMany
CSNK1B 34
  • 72 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 90 (a)
ManyToMany
-- 34
  • 89 (a)
ManyToMany
-- 34
  • 83 (a)
ManyToMany
-- 34
  • 75 (a)
ManyToMany
-- 34
  • 75 (a)
ManyToMany
-- 34
  • 71 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 86 (a)
ManyToMany
chicken
(Gallus gallus)
Aves CSNK1A1 34
  • 84 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 84 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii csnk1a1 33 34 34
  • 80.13 (n)
fruit fly
(Drosophila melanogaster)
Insecta CkIalpha 34
  • 71 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea kin-19 33 34
  • 68.85 (n)
rice
(Oryza sativa)
Liliopsida Os10g0476300 33
  • 64.16 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 85 (a)
ManyToMany
CS-CKI 34
  • 82 (a)
ManyToMany
Species where no ortholog for CSNK1A1L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CSNK1A1L Gene

ENSEMBL:
Gene Tree for CSNK1A1L (if available)
TreeFam:
Gene Tree for CSNK1A1L (if available)

Paralogs for CSNK1A1L Gene

Paralogs for CSNK1A1L Gene

(6) SIMAP similar genes for CSNK1A1L Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CSNK1A1L: view

Variants for CSNK1A1L Gene

Sequence variations from dbSNP and Humsavar for CSNK1A1L Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs56158728 A colorectal cancer sample 37,105,196(+) CTTCC(A/G)CACCA reference, missense
rs1000227474 -- 37,105,554(+) GCACA(A/G)CGAGT utr-variant-5-prime
rs1000326070 -- 37,102,964(+) TAGGG(A/G)GGGTC downstream-variant-500B
rs1000378569 -- 37,102,807(+) TCCTG(A/C)CATGC downstream-variant-500B
rs1001649216 -- 37,105,064(+) AATCG(C/T)GTAGA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CSNK1A1L Gene

Variant ID Type Subtype PubMed ID
esv3892330 CNV gain 25118596
nsv826612 CNV loss 20364138

Variation tolerance for CSNK1A1L Gene

Residual Variation Intolerance Score: 89.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.76; 73.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CSNK1A1L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CSNK1A1L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSNK1A1L Gene

Disorders for CSNK1A1L Gene

Relevant External Links for CSNK1A1L

Genetic Association Database (GAD)
CSNK1A1L
Human Genome Epidemiology (HuGE) Navigator
CSNK1A1L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CSNK1A1L

No disorders were found for CSNK1A1L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CSNK1A1L Gene

Publications for CSNK1A1L Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  3. Identification of Novel Nuclear Factor of Activated T Cell (NFAT)-associated Proteins in T Cells. (PMID: 27637333) Gabriel CH … Baumgrass R (The Journal of biological chemistry 2016) 3 60
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60
  5. FBXW7 modulates cellular stress response and metastatic potential through ​HSF1 post-translational modification. (PMID: 25720964) Kourtis N … Aifantis I (Nature cell biology 2015) 3 60

Products for CSNK1A1L Gene

Sources for CSNK1A1L Gene

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