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Aliases for CSNK1A1L Gene

Aliases for CSNK1A1L Gene

  • Casein Kinase 1, Alpha 1-Like 2 3
  • CKI-Alpha-Like 3 4
  • EC 2.7.11.1 4 63
  • CK1 3 4
  • Casein Kinase I Isoform Alpha-Like 3
  • Casein Kinase I Alpha S-Like 3
  • EC 2.7.11 63

External Ids for CSNK1A1L Gene

Summaries for CSNK1A1L Gene

GeneCards Summary for CSNK1A1L Gene

CSNK1A1L (Casein Kinase 1, Alpha 1-Like) is a Protein Coding gene. Diseases associated with CSNK1A1L include sleep disorder and angina pectoris. Among its related pathways are Wnt signaling pathway (KEGG) and Translation Insulin regulation of translation. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is CSNK1G2.

UniProtKB/Swiss-Prot for CSNK1A1L Gene

  • Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSNK1A1L Gene

Genomics for CSNK1A1L Gene

Genomic Location for CSNK1A1L Gene

Start:
37,103,259 bp from pter
End:
37,105,664 bp from pter
Size:
2,406 bases
Orientation:
Minus strand

Genomic View for CSNK1A1L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CSNK1A1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSNK1A1L Gene

Regulatory Elements for CSNK1A1L Gene

Proteins for CSNK1A1L Gene

  • Protein details for CSNK1A1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N752-KC1AL_HUMAN
    Recommended name:
    Casein kinase I isoform alpha-like
    Protein Accession:
    Q8N752
    Secondary Accessions:
    • Q5T2N2

    Protein attributes for CSNK1A1L Gene

    Size:
    337 amino acids
    Molecular mass:
    39086 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CSNK1A1L Gene

Proteomics data for CSNK1A1L Gene at MOPED

Post-translational modifications for CSNK1A1L Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys130

Other Protein References for CSNK1A1L Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for CSNK1A1L Gene

Gene Families for CSNK1A1L Gene

Protein Domains for CSNK1A1L Gene

Suggested Antigen Peptide Sequences for CSNK1A1L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N752

UniProtKB/Swiss-Prot:

KC1AL_HUMAN
Domain:
  • Contains 1 protein kinase domain.:
    • Q8N752
Family:
  • Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.:
    • Q8N752
genes like me logo Genes that share domains with CSNK1A1L: view

Function for CSNK1A1L Gene

Molecular function for CSNK1A1L Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot Function: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity).

Enzyme Numbers (IUBMB) for CSNK1A1L Gene

Gene Ontology (GO) - Molecular Function for CSNK1A1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IBA --
GO:0004713 protein tyrosine kinase activity --
GO:0005524 ATP binding IEA --
GO:0016772 transferase activity, transferring phosphorus-containing groups --
genes like me logo Genes that share ontologies with CSNK1A1L: view

Phenotypes for CSNK1A1L Gene

GenomeRNAi human phenotypes for CSNK1A1L:
genes like me logo Genes that share phenotypes with CSNK1A1L: view

miRNA for CSNK1A1L Gene

miRTarBase miRNAs that target CSNK1A1L

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for CSNK1A1L Gene

Localization for CSNK1A1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSNK1A1L Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CSNK1A1L Gene COMPARTMENTS Subcellular localization image for CSNK1A1L gene
Compartment Confidence
cytosol 3
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CSNK1A1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
GO:0030529 ribonucleoprotein complex IEA --
genes like me logo Genes that share ontologies with CSNK1A1L: view

Pathways for CSNK1A1L Gene

genes like me logo Genes that share pathways with CSNK1A1L: view

Pathways by source for CSNK1A1L Gene

1 GeneGo (Thomson Reuters) pathway for CSNK1A1L Gene
2 Sino Biological pathways for CSNK1A1L Gene
2 KEGG pathways for CSNK1A1L Gene

Interacting Proteins for CSNK1A1L Gene

Gene Ontology (GO) - Biological Process for CSNK1A1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000902 cell morphogenesis IEA --
GO:0006468 protein phosphorylation --
GO:0006909 phagocytosis IBA --
GO:0008360 regulation of cell shape IBA --
GO:0016055 Wnt signaling pathway IBA --
genes like me logo Genes that share ontologies with CSNK1A1L: view

Compounds for CSNK1A1L Gene

(9) Novoseek inferred chemical compound relationships for CSNK1A1L Gene

Compound -log(P) Hits PubMed IDs
hymenialdisine 89.3 3
ic261 88.6 3
glycogen 55.9 8
serine 41.4 3
phosphoserine 40.1 1
genes like me logo Genes that share compounds with CSNK1A1L: view

Transcripts for CSNK1A1L Gene

mRNA/cDNA for CSNK1A1L Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CSNK1A1L Gene

Casein kinase 1, alpha 1-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CSNK1A1L Gene

No ASD Table

Relevant External Links for CSNK1A1L Gene

GeneLoc Exon Structure for
CSNK1A1L
ECgene alternative splicing isoforms for
CSNK1A1L

Expression for CSNK1A1L Gene

mRNA expression in normal human tissues for CSNK1A1L Gene

mRNA differential expression in normal tissues according to GTEx for CSNK1A1L Gene

This gene is overexpressed in Testis (25.1) and Whole Blood (17.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CSNK1A1L Gene

SOURCE GeneReport for Unigene cluster for CSNK1A1L Gene Hs.512897

genes like me logo Genes that share expressions with CSNK1A1L: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CSNK1A1L Gene

Orthologs for CSNK1A1L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CSNK1A1L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CSNK1A1L 35
  • 99.6 (n)
  • 99.11 (a)
CSNK1A1L 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CSNK1A1 36
  • 90 (a)
ManyToMany
CSNK1B 36
  • 72 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 86 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Csnk1a1 36
  • 92 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 83 (a)
ManyToMany
-- 36
  • 75 (a)
ManyToMany
-- 36
  • 75 (a)
ManyToMany
-- 36
  • 90 (a)
ManyToMany
-- 36
  • 89 (a)
ManyToMany
-- 36
  • 71 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 95 (a)
OneToMany
chicken
(Gallus gallus)
Aves CSNK1A1 36
  • 84 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 84 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii csnk1a1 35
  • 80.13 (n)
  • 91.99 (a)
csnk1a1 36
  • 83 (a)
ManyToMany
csnk1a1 36
  • 83 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CkIalpha 36
  • 71 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea kin-19 35
  • 68.85 (n)
  • 82.62 (a)
kin-19 36
  • 76 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os10g0476300 35
  • 64.16 (n)
  • 66.89 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 85 (a)
ManyToMany
CS-CKI 36
  • 82 (a)
ManyToMany
Species with no ortholog for CSNK1A1L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CSNK1A1L Gene

ENSEMBL:
Gene Tree for CSNK1A1L (if available)
TreeFam:
Gene Tree for CSNK1A1L (if available)

Paralogs for CSNK1A1L Gene

Selected SIMAP similar genes for CSNK1A1L Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CSNK1A1L: view

Variants for CSNK1A1L Gene

Sequence variations from dbSNP and Humsavar for CSNK1A1L Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs17054882 - 37,104,728(+) ATCTT(C/T)TCTGT missense, reference
rs17054900 -- 37,106,895(+) ATGGC(C/T)AGGTC upstream-variant-2KB
rs11147627 -- 37,105,964(+) TCCCA(C/T)CTACT upstream-variant-2KB
rs11147626 -- 37,105,949(+) CGGGC(C/T)CAGTC upstream-variant-2KB
rs11147625 -- 37,105,944(+) GTTTT(C/T)GGGCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CSNK1A1L Gene

Variant ID Type Subtype PubMed ID
nsv826612 CNV Loss 20364138

Relevant External Links for CSNK1A1L Gene

HapMap Linkage Disequilibrium report
CSNK1A1L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSNK1A1L Gene

Disorders for CSNK1A1L Gene

(2) Novoseek inferred disease relationships for CSNK1A1L Gene

Disease -log(P) Hits PubMed IDs
alzheimers disease 46.5 2
brain diseases 22.9 1

Relevant External Links for CSNK1A1L

Genetic Association Database (GAD)
CSNK1A1L
Human Genome Epidemiology (HuGE) Navigator
CSNK1A1L
genes like me logo Genes that share disorders with CSNK1A1L: view

No data available for UniProtKB/Swiss-Prot for CSNK1A1L Gene

Publications for CSNK1A1L Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Functional specialization of beta-arrestin interactions revealed by proteomic analysis. (PMID: 17620599) Xiao K. … Lefkowitz R.J. (Proc. Natl. Acad. Sci. U.S.A. 2007) 3
  3. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PMID: 20360068) Hutchins J.R. … Peters J.M. (Science 2010) 3
  4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3
  5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3

Products for CSNK1A1L Gene

Sources for CSNK1A1L Gene

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