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Aliases for CSNK1A1L Gene

Aliases for CSNK1A1L Gene

  • Casein Kinase 1 Alpha 1 Like 2 3
  • Casein Kinase 1, Alpha 1-Like 2 3 5
  • CKI-Alpha-Like 3 4
  • EC 2.7.11.1 4 63
  • CK1 3 4
  • Casein Kinase I Alpha S-Like 3
  • EC 2.7.11 63

External Ids for CSNK1A1L Gene

Previous GeneCards Identifiers for CSNK1A1L Gene

  • GC13M035476
  • GC13M036575
  • GC13M037677
  • GC13M018489

Summaries for CSNK1A1L Gene

GeneCards Summary for CSNK1A1L Gene

CSNK1A1L (Casein Kinase 1 Alpha 1 Like) is a Protein Coding gene. Among its related pathways are Translation Insulin regulation of translation and Wnt signaling pathway (KEGG). GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CSNK1G2.

UniProtKB/Swiss-Prot for CSNK1A1L Gene

  • Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSNK1A1L Gene

Genomics for CSNK1A1L Gene

Regulatory Elements for CSNK1A1L Gene

Genomic Location for CSNK1A1L Gene

Chromosome:
13
Start:
37,103,259 bp from pter
End:
37,105,664 bp from pter
Size:
2,406 bases
Orientation:
Minus strand

Genomic View for CSNK1A1L Gene

Genes around CSNK1A1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CSNK1A1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CSNK1A1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSNK1A1L Gene

Proteins for CSNK1A1L Gene

  • Protein details for CSNK1A1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N752-KC1AL_HUMAN
    Recommended name:
    Casein kinase I isoform alpha-like
    Protein Accession:
    Q8N752
    Secondary Accessions:
    • Q5T2N2

    Protein attributes for CSNK1A1L Gene

    Size:
    337 amino acids
    Molecular mass:
    39086 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CSNK1A1L Gene

Proteomics data for CSNK1A1L Gene at MOPED

Post-translational modifications for CSNK1A1L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CSNK1A1L Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for CSNK1A1L Gene

Gene Families for CSNK1A1L Gene

Protein Domains for CSNK1A1L Gene

Suggested Antigen Peptide Sequences for CSNK1A1L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N752

UniProtKB/Swiss-Prot:

KC1AL_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
genes like me logo Genes that share domains with CSNK1A1L: view

Function for CSNK1A1L Gene

Molecular function for CSNK1A1L Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity).

Enzyme Numbers (IUBMB) for CSNK1A1L Gene

genes like me logo Genes that share phenotypes with CSNK1A1L: view

Animal Model Products

miRNA for CSNK1A1L Gene

miRTarBase miRNAs that target CSNK1A1L

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CSNK1A1L Gene

Localization for CSNK1A1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSNK1A1L Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CSNK1A1L Gene COMPARTMENTS Subcellular localization image for CSNK1A1L gene
Compartment Confidence
cytosol 3
nucleus 2
mitochondrion 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for CSNK1A1L Gene

Pathways & Interactions for CSNK1A1L Gene

genes like me logo Genes that share pathways with CSNK1A1L: view

Pathways by source for CSNK1A1L Gene

2 Sino Biological pathways for CSNK1A1L Gene
2 KEGG pathways for CSNK1A1L Gene
1 GeneGo (Thomson Reuters) pathway for CSNK1A1L Gene

Interacting Proteins for CSNK1A1L Gene

SIGNOR curated interactions for CSNK1A1L Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for CSNK1A1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006909 phagocytosis IBA --
GO:0008360 regulation of cell shape IBA --
GO:0018105 peptidyl-serine phosphorylation IBA --
genes like me logo Genes that share ontologies with CSNK1A1L: view

Drugs & Compounds for CSNK1A1L Gene

(5) Drugs for CSNK1A1L Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for CSNK1A1L Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CSNK1A1L: view

Transcripts for CSNK1A1L Gene

mRNA/cDNA for CSNK1A1L Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CSNK1A1L Gene

Casein kinase 1, alpha 1-like:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CSNK1A1L Gene

No ASD Table

Relevant External Links for CSNK1A1L Gene

GeneLoc Exon Structure for
CSNK1A1L
ECgene alternative splicing isoforms for
CSNK1A1L

Expression for CSNK1A1L Gene

mRNA expression in normal human tissues for CSNK1A1L Gene

mRNA differential expression in normal tissues according to GTEx for CSNK1A1L Gene

This gene is overexpressed in Testis (x25.1) and Whole Blood (x17.1).

Protein differential expression in normal tissues from HIPED for CSNK1A1L Gene

This gene is overexpressed in Cervix (44.2) and Heart (24.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CSNK1A1L Gene



SOURCE GeneReport for Unigene cluster for CSNK1A1L Gene Hs.512897

genes like me logo Genes that share expression patterns with CSNK1A1L: view

Protein tissue co-expression partners for CSNK1A1L Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CSNK1A1L Gene

Orthologs for CSNK1A1L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CSNK1A1L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CSNK1A1L 35
  • 99.6 (n)
  • 99.11 (a)
CSNK1A1L 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CSNK1A1 36
  • 90 (a)
ManyToMany
CSNK1B 36
  • 72 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 86 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 83 (a)
ManyToMany
-- 36
  • 75 (a)
ManyToMany
-- 36
  • 75 (a)
ManyToMany
-- 36
  • 90 (a)
ManyToMany
-- 36
  • 89 (a)
ManyToMany
-- 36
  • 71 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Csnk1a1 36
  • 92 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 95 (a)
OneToMany
chicken
(Gallus gallus)
Aves CSNK1A1 36
  • 84 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 84 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii csnk1a1 35
  • 80.13 (n)
  • 91.99 (a)
csnk1a1 36
  • 83 (a)
ManyToMany
csnk1a1 36
  • 83 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CkIalpha 36
  • 71 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea kin-19 35
  • 68.85 (n)
  • 82.62 (a)
kin-19 36
  • 76 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os10g0476300 35
  • 64.16 (n)
  • 66.89 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 85 (a)
ManyToMany
CS-CKI 36
  • 82 (a)
ManyToMany
Species with no ortholog for CSNK1A1L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CSNK1A1L Gene

ENSEMBL:
Gene Tree for CSNK1A1L (if available)
TreeFam:
Gene Tree for CSNK1A1L (if available)

Paralogs for CSNK1A1L Gene

(6) SIMAP similar genes for CSNK1A1L Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CSNK1A1L: view

Variants for CSNK1A1L Gene

Sequence variations from dbSNP and Humsavar for CSNK1A1L Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs17773251 - 37,104,747(+) TGTTG(C/G)CTGGT reference, missense
rs56158728 A colorectal cancer sample, - 37,105,196(+) CTTCC(A/G)CACCA reference, missense
rs56224973 - 37,105,244(+) GCCGC(A/C/T)GTTGT reference, missense
rs9576175 - 37,105,131(+) GCTAC(G/T)TCCTC reference, missense
rs17054882 - 37,104,728(+) ATCTT(C/T)TCTGT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CSNK1A1L Gene

Variant ID Type Subtype PubMed ID
nsv826612 CNV Loss 20364138

Variation tolerance for CSNK1A1L Gene

Residual Variation Intolerance Score: 89.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.76; 73.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CSNK1A1L Gene

HapMap Linkage Disequilibrium report
CSNK1A1L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSNK1A1L Gene

Disorders for CSNK1A1L Gene

Relevant External Links for CSNK1A1L

Genetic Association Database (GAD)
CSNK1A1L
Human Genome Epidemiology (HuGE) Navigator
CSNK1A1L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CSNK1A1L

No disorders were found for CSNK1A1L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CSNK1A1L Gene

Publications for CSNK1A1L Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. FBXW7 modulates cellular stress response and metastatic potential through a88HSF1 post-translational modification. (PMID: 25720964) Kourtis N. … Aifantis I. (Nat. Cell Biol. 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry. (PMID: 24332808) Marechal A. … Zou L. (Mol. Cell 2014) 3
  5. Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. (PMID: 23362303) Wu J.H. … Mozaffarian D. (Circ Cardiovasc Genet 2013) 3

Products for CSNK1A1L Gene

Sources for CSNK1A1L Gene

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