CSNK1A1L Gene
protein-coding GIFtS: 53
GCID: GC13M037677
|
|
casein kinase 1, alpha 1-like
| |
Aliases for CSNK1A1L gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Casein Kinase 1, Alpha 1-Like1 2 | | MGC331821 | | CK12 3 | | Casein Kinase I Alpha S-Like2 | | CKI-Alpha-Like1 | | Casein Kinase I Isoform Alpha-Like2 | | EC 2.7.11.13 8 | | EC 2.7.118 |
Export aliases for CSNK1A1L gene to outside databasesPrevious GC identifers: GC13M035476 GC13M036575 GC13M018489 |
Summaries for CSNK1A1L gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: KC1AL_HUMAN, Q8N752Function: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseinsas substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity)
|
Genomic Views for CSNK1A1L gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000013.10 NC_018924.1 NT_024524.14
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the CSNK1A1L gene promoter: Nkx3-1 Nkx3-1 v1 CUTL1 AP-4 LCR-F1 E47 S8 Nkx6-1 CP2 Hand1 Other transcription factors
Search SABiosciences Chromatin IP Primers for CSNK1A1L
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CSNK1A1L |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 13q13.3 Ensembl cytogenetic band: 13q13.3 HGNC cytogenetic band: 13q13.2CSNK1A1L Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 13 GeneLoc Exon Structure GeneLoc location for GC13M037677: view genomic region
(about GC identifiers)
Start:
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37,677,397 bp from pter |
End:
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37,679,803 bp from pter |
Size:
|
2,407 bases |
Orientation:
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minus strand |
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Proteins for CSNK1A1L gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: KC1AL_HUMAN, Q8N752 (See
protein sequence)Recommended Name: Casein kinase I isoform alpha-like Size: 337 amino acids; 39086 Da
Subcellular location: Cytoplasm (By similarity)
Secondary accessions: Q5T2N2Explore the universe of human proteins at neXtProt for CSNK1A1L: NX_Q8N752
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N752 4/17 DME Specific Peptides for CSNK1A1L (Q8N752) (see all 17)
CSNK1A1L Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_660204.2 ENSEMBL proteins: ENSP00000369126 Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- | | GO:0030529 | ribonucleoprotein complex |
IEA | -- |
CSNK1A1L for ontologies About GeneDecksing
CSNK1A1L Antibody Products: Assay Products for CSNK1A1L: |
Protein
Domains / Families for CSNK1A1L gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CSNK1A1L for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8N752ProtoNet protein and cluster: Q8N752 UniProtKB/Swiss-Prot: KC1AL_HUMAN, Q8N752Similarity: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamilySimilarity: Contains 1 protein kinase domain |
Function for CSNK1A1L gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: KC1AL_HUMAN, Q8N752Function: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseinsas substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity)Catalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CSNK1A1L OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CSNK1A1L OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CSNK1A1L (NM_145203) | |  | Sino Biological Human cDNA Clone for CSNK1A1L | |  | DNA2.0 Custom Codon Optimized Gene
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In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSNK1A1L |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004674 | protein serine/threonine kinase activity |
IEA | -- | | GO:0005524 | ATP binding |
IEA | -- |
CSNK1A1L for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for CSNK1A1L:
|
Pathways & Interactions for CSNK1A1L gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Development_CNTF receptor signaling | | | 2 | Basal cell carcinoma | | | 3 | Wnt Signaling Pathway | |
Pathway sources See GeneCards unified pathways Show all pathways
1 EMD Millipore Pathway for CSNK1A1L
1 GeneGo (Thomson Reuters) Pathway for CSNK1A1L
2
Kegg Pathways (Kegg details for CSNK1A1L):
CSNK1A1L for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CSNK1A1L
STRING Interaction
Network Preview (showing 5 interactants - click image to see 10)
 5/11 Interacting proteins for CSNK1A1L (Q8N7523 ENSP000003691264) via UniProtKB, MINT, STRING, and/or I2D (see all 11)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000902 | cell morphogenesis |
IEA | -- | | GO:0016055 | Wnt receptor signaling pathway |
IEA | -- |
CSNK1A1L for ontologies About GeneDecksing
|
Drugs & Compounds for CSNK1A1L gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CSNK1A1L for compounds About GeneDecksing
Browse Tocris compounds for CSNK1A1L 9 Novoseek chemical compound relationships for CSNK1A1L gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| hymenialdisine |
89.3 |
4 |
10662688 (1), 15261294 (1), 15123286 (1) |
| ic261 |
88.6 |
5 |
14761950 (1), 17353278 (1), 14710188 (1) |
| glycogen |
55.9 |
11 |
12894878 (1), 12903511 (1), 16386907 (1), 1651242 (1) (see all 8) |
| serine |
41.4 |
6 |
1651242 (1), 16014721 (1), 14744247 (1) |
| phosphoserine |
40.1 |
1 |
11781102 (1) |
| threonine |
30 |
1 |
16014721 (1) |
| atp |
7.68 |
2 |
8529658 (1), 16751335 (1) |
| creatinine |
0.274 |
2 |
9851645 (1), 18560415 (1) |
| glutamate |
0 |
2 |
16014721 (2) |
Search CenterWatch for drugs/clinical trials and news about CSNK1A1L / KC1AL 
|
Transcripts for CSNK1A1L gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for CSNK1A1L gene: NM_145203.5 Unigene Cluster for CSNK1A1L: Casein kinase 1, alpha 1-like Hs.512897 [show with all ESTs]Unigene Representative Sequence: BC0287231 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000379800(uc001uwm.1)
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CSNK1A1L OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CSNK1A1L OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CSNK1A1L (NM_145203) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CSNK1A1L | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSNK1A1L  |
Additional cDNA sequence: BC028723.2 2 DOTS entries: DT.100035422 DT.97862239 3 AceView cDNA sequences: NM_145203 BC028723 BI459748 GeneLoc Exon Structure
|
Expression for CSNK1A1L gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CSNK1A1L expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: ATATTCCCTT
About this image See CSNK1A1L Protein Expression from SPIRE MOPED and PaxDB SOURCE GeneReport for Unigene cluster: Hs.512897 SABiosciences Custom PCR Arrays for CSNK1A1L
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CSNK1A1L Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CSNK1A1L | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CSNK1A1L | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CSNK1A1L | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSNK1A1L |
Orthologs for CSNK1A1L gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for CSNK1A1L gene from 7/22 species (see all 22) About this table
ENSEMBL Gene Tree for CSNK1A1L (if available) TreeFam Gene Tree for CSNK1A1L (if available)  |
Paralogs for CSNK1A1L gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for CSNK1A1L gene
- VRK32 VRK12 CSNK1G32 VRK22 CSNK1D2 CSNK1A12 CSNK1G22 TTBK12
- CSNK1G12 CSNK1E2 TTBK22
6 SIMAP similar genes for CSNK1A1L using alignment to 1 protein entry: KC1AL_HUMAN:CSNK1A1 CSNK1E CSNK1D CSNK1G1 CSNK1G3 CSNK1G2
CSNK1A1L for paralogs About GeneDecksing
|
Genomic Variants for CSNK1A1L gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 13 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for CSNK1A1L (37677397 - 37679803 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for CSNK1A1L: -- Human Gene Mutation Database (HGMD): CSNK1A1L
 | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CSNK1A1L |
|
Disorders
/ Diseases for CSNK1A1L gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CSNK1A1L for disorders About GeneDecksing
14 diseases for CSNK1A1L: About MalaCardsamyotrophic lateral sclerosis lateral sclerosis systemic lupus erythematosus lupus erythematosus ataxia telangiectasia sleep disorder ulcerative colitis brain disease alzheimer's disease parkinson's disease ataxia cholesterol malaria prostatitis
2 Novoseek disease relationships for CSNK1A1L gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| alzheimers disease |
46.5 |
2 |
14761950 (1), 19665384 (1) |
| brain diseases |
22.9 |
1 |
14761950 (1) |
Human Genome Epidemiology (HuGE) Navigator: CSNK1A1L (1 document) Export disorders for CSNK1A1L gene to outside databases
|
Publications for CSNK1A1L gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CSNK1A1L gene, integrated from 9 sources (see all 93): (articles sorted by number of sources associating them with CSNK1A1L) | |  | Utopia: connect your pdf to the dynamic world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
- Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)2 Greenman C.... Stratton M.R. (2007)
- Functional specialization of beta-arrestin interactions revealed by proteomic analysis. (PubMed id 17620599)1 Xiao K....Lefkowitz R.J. (2007)
- The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
- The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)2 Dunham A.... Ross M.T. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- The microbial receptor CEACAM3 is linked to the calprotectin complex in granulocytes. (PubMed id 11708798)1 Streichert T....Bruemmer J. (2001)
|
External Searches for CSNK1A1L gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing CSNK1A1L gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CSNK1A1L gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CSNK1A1L gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for CSNK1A1L | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CSNK1A1L gene: Search GeneIP for patents involving CSNK1A1L
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for CSNK1A1L gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CSNK1A1L | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CSNK1A1L | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CSNK1A1L | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CSNK1A1L | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CSNK1A1L | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CSNK1A1L |
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 | | CSNK1A1L Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSNK1A1L |
|  |  |  | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSNK1A1L |
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