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CSNK1A1 Gene

protein-coding   GIFtS: 72
GCID: GC05M148854

Casein Kinase 1, Alpha 1

  See CSNK1A1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Casein Kinase 1, Alpha 11 2     HEL-S-77p2
Clock Regulator Kinase1 2     HLCDGP12
CK12 3     PRO29752
CKI-alpha2 3     Casein Kinase I Isoform Alpha2
EC 2.7.11.13 8     Down-Regulated In Lung Cancer2
CK1a2     Epididymis Secretory Sperm Binding Protein Li 77p2
CKIa2     

External Ids:    HGNC: 24511   Entrez Gene: 14522   Ensembl: ENSG000001137127   OMIM: 6005055   UniProtKB: P487293   

Export aliases for CSNK1A1 gene to outside databases

Previous GC identifers: GC05M148919 GC05M149467 GC05M148904 GC05M148902 GC05M144021


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CSNK1A1 Gene:
CSNK1A1 (casein kinase 1, alpha 1) is a protein-coding gene. Diseases associated with CSNK1A1 include lung cancer. GO annotations related to this gene include protein serine/threonine kinase activity and protein kinase activity. An important paralog of this gene is VRK3.

UniProtKB/Swiss-Prot: KC1A_HUMAN, P48729
Function: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as
caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling.
Phosphorylates CTNNB1 at 'Ser-45'. May play a role in segregating chromosomes during mitosis

summary for CSNK1A1 Gene:
Casein kinase I (CK1) is a monomeric serine-threonine protein kinase with 7 isoforms: alpha, beta, gamma1,
gamma2, gamma3, delta and epsilon. CK1 is involved in a number of cellular processes including DNA repair,
cell division, nuclear localization and membrane transport. CK1 isoforms also have key roles in the
developmentally important Wnt and Hedgehog (Hh) signaling pathways. When Wnt is not bound to its receptor,
CK1alpha is thought to phosphorylate beta-catenin as part of its degradation process. Upon binding of Wnt to
its receptor (Frizzled) CK1epsilon phosphorylates the intracellular signaling protein, Dishevelled and
CK1gamma directly phosphorylates the LRP5/6 co-receptor. These actions of CK1 facilitate signal transduction
to the transcription factor, TCF, which mediates transcription of Wnt regulated genes. Similarly, CK1alpha
plays a role in regulating Hh signaling by phosphorylating the signaling effector Ci-155 in the Hh unbound
state, and then when Hh binds to Patched, CK1alpha phosphorylates the 7-TM co-receptor, Smoothened.

Gene Wiki entry for CSNK1A1 (Casein kinase 1, alpha 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_029289.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the CSNK1A1 gene promoter:
         STAT1   AML1a   p300   Lmo2   LUN-1   Evi-1   Egr-2   CREB   FAC1   Sox9   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCSNK1A1 promoter sequence
   Search Chromatin IP Primers for CSNK1A1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CSNK1A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q32   Ensembl cytogenetic band:  5q32   HGNC cytogenetic band: 5q32

CSNK1A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CSNK1A1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M148854:  view genomic region     (about GC identifiers)

Start:
148,871,760 bp from pter      End:
148,931,007 bp from pter
Size:
59,248 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: KC1A_HUMAN, P48729 (See protein sequence)
Recommended Name: Casein kinase I isoform alpha  
Size: 337 amino acids; 38915 Da
Subunit: Monomer. Interacts with the Axin complex. Interacts with TUT1, leading to TUT1 phosphorylation
Secondary accessions: D3DQG0 D3DQG1 Q4JJA0 Q5U046 Q5U047 Q6FGA2 Q96HD2 Q9UDK3
Alternative splicing: 2 isoforms:  P48729-1   P48729-2   (Contains a phosphoserine at position 156)

Explore the universe of human proteins at neXtProt for CSNK1A1: NX_P48729

Explore proteomics data for CSNK1A1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys8, Lys62, Lys65, Lys138, Lys225, Lys304
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CSNK1A1 (P48729) (see all 21)
     QGGVGIP  ESKLYKI  PDNFLMG  WYGQEKD 


    See CSNK1A1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001020276.1  NP_001258670.1  NP_001258671.1  NP_001883.4  

    ENSEMBL proteins: 
     ENSP00000261798   ENSP00000426747   ENSP00000427031   ENSP00000475319   ENSP00000421689  
     ENSP00000475969   ENSP00000425366   ENSP00000475633   ENSP00000430252   ENSP00000421268  
     ENSP00000367074  
    Reactome Protein details: P48729

    CSNK1A1 Human Recombinant Protein Products:

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    Sino Biological Cell Lysate for CSNK1A1
    ProSpec Recombinant Protein for CSNK1A1
    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online proteins for CSNK1A1 (15 products) 

     
    antibodies-online peptides for CSNK1A1

    CSNK1A1 Antibody Products:

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    antibodies-online antibodies for CSNK1A1 (100 products) 

    CSNK1A1 Assay Products:

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    antibodies-online kits for CSNK1A1 (11 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: casein kinase 1, alpha 1
    Casein kinase 1 (CK1) family

    4 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry P48729

    ProtoNet protein and cluster: P48729

    UniProtKB/Swiss-Prot: KC1A_HUMAN, P48729
    Similarity: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I
    subfamily
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with CSNK1A1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KC1A_HUMAN, P48729
    Function: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as
    caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling.
    Phosphorylates CTNNB1 at 'Ser-45'. May play a role in segregating chromosomes during mitosis
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Genatlas biochemistry entry for CSNK1A1:
    casein kinase I,catalytic unit,alpha 1,involved in the transduction of WNT signal

         Enzyme Number (IUBMB): EC 2.7.11.11 2

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity TAS10777483
    GO:0004674protein serine/threonine kinase activity IDA18305108
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI16511560
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with CSNK1A1           About GenesLikeMe


    Phenotypes:
         9 GenomeRNAi human phenotypes for CSNK1A1:
     Decreased cilium length after   Decreased focal adhesion (FA)   Decreased homologous recombina  Decreased substrate adherent c 
     Increased cell death in HCT116  Increased circadian period len  Increased viability with 4OH t  Upregulation of Wnt/beta-caten 
     Wnt reporter downregulated 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Csnk1a1):
     cellular  digestive/alimentary  mortality/aging  tumorigenesis 

    Find genes that share phenotypes with CSNK1A1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Csnk1a1tm1.2Ybn for CSNK1A1

       genOway: Develop your customized and physiologically relevant rodent model for CSNK1A1

    miRNA
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    miRTarBase miRNAs that target CSNK1A1:
    hsa-mir-324-3p (MIRT042900), hsa-mir-186-5p (MIRT021178), hsa-mir-155-5p (MIRT006267), hsa-mir-21-5p (MIRT030896), hsa-mir-652-3p (MIRT039466)

    Block miRNA regulation of human, mouse, rat CSNK1A1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CSNK1A1 (see all 53):
    hsa-miR-576-3p hsa-miR-3678-3p hsa-miR-4307 hsa-miR-605 hsa-miR-30d hsa-miR-628-3p hsa-miR-502-3p hsa-miR-4275
    SwitchGear 3'UTR luciferase reporter plasmidCSNK1A1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CSNK1A1

    Gene Editing
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CSNK1A1
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    Addgene plasmids for CSNK1A1 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSNK1A1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KC1A_HUMAN, P48729: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome,
    centromere, kinetochore. Nucleus speckle. Note=Localizes to the centrosome in interphase cells, and to
    kinetochore fibers during mitosis
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    cytosol4
    golgi apparatus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000777condensed chromosome kinetochore IEA--
    GO:0005813centrosome IDA--
    GO:0005829cytosol TAS--
    GO:0005847colocalizes with mRNA cleavage and polyadenylation specificity factor complex IDA18305108
    GO:0016607nuclear speck IDA18305108

    Find genes that share ontologies with CSNK1A1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CSNK1A1 About   (see all 24)  
    See pathways by source

    SuperPathContained pathways About
    1Wnt signaling pathway (KEGG)
    Wnt signaling pathway0.40
    Wnt Signaling Pathway NetPath0.37
    Wnt Signaling Pathways0.40
    2CDK-mediated phosphorylation and removal of Cdc6
    Degradation of beta-catenin by the destruction complex0.73
    Beta-catenin phosphorylation cascade0.00
    3Non-Canonical Wnt Pathway
    Non-Canonical Wnt Pathway0.53
    Canonical Wnt Pathway0.53
    4beta-catenin independent WNT signaling
    Signaling by Wnt0.79
    5Nanog in Mammalian ESC Pluripotency
    GSK3 Signaling0.61


    Find genes that share SuperPaths with CSNK1A1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CSNK1A1
        Wnt Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CSNK1A1 (see all 6)
        GSK3 Signaling
    NFAT and Cardiac Hypertrophy
    Signaling in Gap Junctions
    WNT Signaling
    Dopamine-DARPP32 Feedback onto cAMP Pathway

    2 Cell Signaling Technology (CST) Pathways for CSNK1A1
        Wnt / Hedgehog / Notch
    DNA Damage

    2 Tocris Bioscience Pathways for CSNK1A1
        Hedgehog Pathway
    Wnt Pathway

    1 GeneGo (Thomson Reuters) Pathway for CSNK1A1
        Translation Regulation of EIF2 activity

    Selected BioSystems Pathways for CSNK1A1 (see all 8)
        Wnt Signaling Pathway NetPath
    Role of Calcineurin-dependent NFAT signaling in lymphocytes
    Canonical Wnt signaling pathway
    FoxO family signaling
    p53 pathway

    2 Sino Biological Pathways for CSNK1A1
        Canonical Wnt Pathway
    Non-Canonical Wnt Pathway

    3 Reactome Pathways for CSNK1A1
        disassembly of the destruction complex and recruitment of AXIN to the membrane
    Degradation of beta-catenin by the destruction complex
    Beta-catenin phosphorylation cascade


    2 Kegg Pathways  (Kegg details for CSNK1A1):
        Wnt signaling pathway
    Hedgehog signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CSNK1A1: 
              Hedgehog Signaling Pathway in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Circadian Rhythms in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CSNK1A1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CSNK1A1 (P487291, 2, 3 ENSP000002617984) via UniProtKB, MINT, STRING, and/or I2D (see all 218)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RCC1P187542, 3, ENSP000003629374MINT-14931 MINT-15051 MINT-14932 I2D: score=4 STRING: ENSP00000362937
    MDM2Q009871, 3, ENSP000004172814EBI-2040168,EBI-389668 I2D: score=2 STRING: ENSP00000417281
    KPNA1P522942, 3, ENSP000003437014MINT-15348 I2D: score=1 STRING: ENSP00000343701
    SYT11Q9BT882, 3, ENSP000003573074MINT-17245 I2D: score=1 STRING: ENSP00000357307
    MDM4O151511, 2, 3, ENSP000003561504EBI-1383726,EBI-398437 MINT-1958437 MINT-3391176 I2D: score=3 STRING: ENSP00000356150
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation IDA18305108
    GO:0007067mitosis IEA--
    GO:0007165signal transduction NAS10777483
    GO:0007166cell surface receptor signaling pathway TAS10777483
    GO:0016055Wnt signaling pathway IEA--

    Find genes that share ontologies with CSNK1A1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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      Browse compounds at ApexBio 

    Compounds for CSNK1A1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    PF 4800567 hydrochlorideSelective casein kinase 1epsilon inhibitor[1188296-52-7]
    D 4476Selective CK1 inhibitor. Also inhibits TGF-betaRI[301836-43-1]
    (R)-DRF053 dihydrochlorideDual CK1/cdk inhibitor[1056016-06-8]
    TAK 715Potent p38 MAPK inhibitor; anti-inflammatory[303162-79-0]
    PF 670462Potent and selective CK1epsilon and CK1delta inhibitor[950912-80-8]

    2 HMDB Compounds for CSNK1A1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    4 Novoseek inferred chemical compound relationships for CSNK1A1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 41.9 1 15722192 (1)
    glycogen 41.6 6 17172446 (1), 15747065 (1), 15327768 (1), 19293931 (1) (see all 5)
    serine 37.8 1 15722192 (1)
    tyrosine 0 2 17172446 (1)



    Find genes that share compounds with CSNK1A1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CSNK1A1 gene (4 alternative transcripts): 
    NM_001025105.2  NM_001271741.1  NM_001271742.1  NM_001892.5  

    Unigene Cluster for CSNK1A1:

    Casein kinase 1, alpha 1
    Hs.529862  [show with all ESTs]
    Unigene Representative Sequence: BX647478
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261798 ENST00000504676 ENST00000515435 ENST00000606719 ENST00000515768
    ENST00000606826 ENST00000503350 ENST00000606299 ENST00000523203 ENST00000515748
    ENST00000377843(uc011dcb.1 uc011dcc.2 uc003lqw.1 uc003lqx.1 uc003lqy.1 uc010jha.1)

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    hsa-miR-576-3p hsa-miR-3678-3p hsa-miR-4307 hsa-miR-605 hsa-miR-30d hsa-miR-628-3p hsa-miR-502-3p hsa-miR-4275
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CSNK1A1
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      QuantiTect SYBR Green Assays in human, mouse, rat CSNK1A1
      QuantiFast Probe-based Assays in human, mouse, rat CSNK1A1

    Additional mRNA sequence: 

    AF447582.1 BC005905.1 BC009186.2 BC020446.2 BC020745.1 BC040473.1 BC067237.1 BC105984.1 
    BX647478.1 BX648552.1 

    22 DOTS entries:

    DT.452922  DT.92391794  DT.95165500  DT.101969880  DT.100861109  DT.100861111  DT.99950970  DT.97862239 
    DT.86859564  DT.100754768  DT.100806837  DT.100861115  DT.95266235  DT.95165465  DT.100038876  DT.100812597 
    DT.120841028  DT.120841032  DT.120841060  DT.91785072  DT.91901551  DT.95266233 

    Selected AceView cDNA sequences (see all 837):

    CA413502 BM698900 AA894795 AI279607 BU857183 AW075531 AA890557 BF109888 
    AI969530 BF060951 AI080202 BI333984 AA911140 CN479199 BP349247 AI630480 
    AF218004 BQ641640 AL134781 BC020446 BM976545 BU687363 AI887495 AA827408 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CSNK1A1 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
    SP1:                                      -     -                 -     -                 -                                         -     -         
    SP2:                                      -     -                 -     -                                                                           
    SP3:                                                              -     -                                                                           
    SP4:                                                              -     -                 -                                                         
    SP5:                    -                 -     -                                                                                                   


    ECgene alternative splicing isoforms for CSNK1A1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CSNK1A1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATGTATGTT
    CSNK1A1 Expression
    About this image


    CSNK1A1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Ovary (Reproductive System)
             Oviduct
     
     Thymus (Hematopoietic System)
             Double Negative 2 Thymocytes Thymus
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    CSNK1A1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CSNK1A1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.529862
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CSNK1A1: 
              Hedgehog Signaling Pathway in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Circadian Rhythms in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CSNK1A1 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Csnk1a11 , 5 casein kinase 1, alpha 11, 5 94.65(n)1
    100(a)1
      18 (34.62 cM)5
    936871  NM_146087.21  NP_666199.11 
     615552745 
    chicken
    (Gallus gallus)
    Aves CSNK1A11 casein kinase 1, alpha 1 90.5(n)
    99.73(a)
      395924  NM_205053.1  NP_990384.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    100(a)
    1 → many
    2(122538154-122589927)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC684332 hypothetical protein MGC68433 83.25(n)    BC057701.1 
    zebrafish
    (Danio rerio)
    Actinopterygii csnk1a12 casein kinase 1, alpha 1 82.52(n)   192307  AF516328.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CkIalpha1 , 3 DNA repair protein kinase3
    Casein kinase Ialpha1
    76(a)
    (best of 6)3
    67.81(n)1
    78.57(a)1
      1 11B73
    322211  NM_001169266.21  NP_001162737.11 
    worm
    (Caenorhabditis elegans)
    Secernentea kin-196
    Protein KIN-19 (kin-19) mRNA, complete cds
    82(a)
    1 → many
    III(4084035-4086636) WBGene00002202
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ckl81 ckl8 61.43(n)
    68.59(a)
      834350  NM_123698.3  NP_199146.1 
    rice
    (Oryza sativa)
    Liliopsida Os04g05148001 Os04g0514800 66.44(n)
    72.35(a)
      4336396  NM_001059844.1  NP_001053309.1 


    ENSEMBL Gene Tree for CSNK1A1 (if available)
    TreeFam Gene Tree for CSNK1A1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CSNK1A1 gene
    VRK32  VRK12  CSNK1G32  VRK22  CSNK1D2  ENSG000002593162  CSNK1G22  CSNK1A1L2  
    TTBK12  CSNK1E2  CSNK1G12  TTBK22  
    11 SIMAP similar genes for CSNK1A1 using alignment to 12 protein entries:     KC1A_HUMAN (see all proteins):
    CSNK1A1L    CSNK1E    CSNK1D    CSNK2A2    CSNK1G2    CSNK1G1
    CSNK2A3    CSNK1G3    TTBK2    TTBK1    VRK1

    Find genes that share paralogs with CSNK1A1           About GenesLikeMe


    5 Pseudogenes.org Pseudogenes for CSNK1A1
    PGOHUM00000242443 PGOHUM00000251178 PGOHUM00000235710 PGOHUM00000250924 PGOHUM00000250925


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CSNK1A1 (see all 1084)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0420734
    A breast pleomorphic lobular carcinoma sample4--see VAR_0420732 D H mis40--------
    rs580054311,2
    C--144060398(+) AAAAA-/AA/A  
     AA
    /AAAA
    GAAGG
    6 -- int11NA 2
    rs1844266721,2
    --148874364(+) TTAATA/TACAGA 2 -- ds50010--------
    rs120546861,2
    C,F,H--148874387(+) CAACCT/GTTTCA 2 -- ds500110Minor allele frequency- G:0.14NS EA 1424
    rs1502740681,2
    --148874765(+) TAAAGC/TAGTTT 2 -- ds50010--------
    rs757365161,2
    --148874833(+) AAACAC/TGTGTC 2 -- ds50010--------
    rs801704581,2
    C--148874837(+) ACGTGG/TCAATT 2 -- ds50010--------
    rs10563441,2
    C,F--148874928(-) CAGGAT/GAAATT 2 -- ut312Minor allele frequency- G:0.04MN NA 304
    rs111674691,2
    C,F,H--148874971(-) ATGATA/TATTTT 6 -- ut31 int15Minor allele frequency- T:0.05NS EA 510
    rs1389214141,2
    C--148875044(+) GGAAGC/TGCACG 6 -- ut31 int10--------

    HapMap Linkage Disequilibrium report for CSNK1A1 (148871760 - 148931007 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for CSNK1A1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2730908CNV Deletion23290073
    nsv5059CNV Insertion18451855
    esv2585670CNV Insertion19546169
    nsv518039CNV Gain19592680
    esv24490CNV Gain19812545
    nsv516848CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CSNK1A1
    DNA2.0 Custom Variant and Variant Library Synthesis for CSNK1A1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600505    OMIM disorders: --

    1 disease for CSNK1A1:    
    About MalaCards
    lung cancer


    Find genes that share disorders with CSNK1A1           About GenesLikeMe

    2 Novoseek inferred disease relationships for CSNK1A1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    familial adenomatous polyposis 33.6 1 15747065 (1)
    cancer 26.8 4 20350806 (1), 15747065 (1), 15722192 (1)

    Genetic Association Database (GAD): CSNK1A1
    Human Genome Epidemiology (HuGE) Navigator: CSNK1A1 (3 documents)

    Export disorders for CSNK1A1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CSNK1A1 gene, integrated from 10 sources (see all 147):
    (articles sorted by number of sources associating them with CSNK1A1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and chromosomal localization of the gene coding for human protein kinase CK1. (PubMed id 8050587)1, 2, 3 Tapia C....Allende J.E. (FEBS Lett. 1994)
    2. Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations. (PubMed id 21642993)1, 4 Wu C....Lin D. (Nat. Genet. 2011)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. CKIalpha is associated with and phosphorylates star-PAP and is also required for expression of select star-PAP target messenger RNAs. (PubMed id 18305108)1, 2 Gonzales M.L.... Anderson R.A. (J. Biol. Chem. 2008)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism. (PubMed id 11955436)1, 2 Liu C.... He X. (Cell 2002)
    7. Isolation and characterization of human casein kinase I epsilon (CKI), a novel member of the CKI gene family. (PubMed id 7797465)1, 2 Fish K.J.... Virshup D.M. (J. Biol. Chem. 1995)
    8. Cell cycle-dependent localization of casein kinase I to mitotic spindles. (PubMed id 1409656)1, 2 Brockman J.L.... Anderson R.A. (Proc. Natl. Acad. Sci. U.S.A. 1992)
    9. Phosphorylation of the proteins of the extracellular matrix of mineralized tissues by casein kinase-like activity. (PubMed id 9391750)1, 9 Veis A....Wu C.B. (Crit. Rev. Oral Biol. Med. 1997)
    10. Casein kinase I associates with members of the centaurin-alpha family of phosphatidylinositol 3,4,5-trisphosphate-binding proteins. (PubMed id 11278595)1, 9 Dubois T....Aitken A. (J. Biol. Chem. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1452 HGNC: 2451 AceView: CSNK1A1 Ensembl:ENSG00000113712 euGenes: HUgn1452
    ECgene: CSNK1A1 Kegg: 1452 H-InvDB: CSNK1A1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CSNK1A1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CSNK1A1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CSNK1A1 gene:
    Search GeneIP for patents involving CSNK1A1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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