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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CSNK1A1 Gene

protein-coding GIFtS: 67
GCID: GC05M148854

casein kinase 1, alpha 1

Explore 20 diseases affiliated with
CSNK1A1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Casein Kinase 1, Alpha 1¹ ²		CKIalpha¹
CK1¹ ² ³		HLCDGP1²
CK1a¹ ²		PRO2975²
CKIa¹ ²		Casein Kinase I Isoform Alpha²
CKI-Alpha¹		Clock Regulator Kinase²
EC 2.7.11.1³ ⁸		Down-Regulated In Lung Cancer²
CK1alpha¹

External Ids:	HGNC: 2451¹	Entrez Gene: 1452²	Ensembl: ENSG00000113712⁷	OMIM: 600505⁵	UniProtKB: P48729³

Export aliases for CSNK1A1 gene to outside databases

Previous GC identifers: GC05M148919 GC05M149467 GC05M148904 GC05M148902 GC05M144021

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: KC1A_HUMAN, P48729

Function: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins

as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1

at 'Ser-45'. May play a role in segregating chromosomes during mitosis

summary for CSNK1A1:

Casein kinase I (CK1) is a monomeric serine-threonine protein kinase with 7 isoforms: alpha, beta, gamma1,

gamma2, gamma3, delta and epsilon. CK1 is involved in a number of cellular processes including DNA repair,

cell division, nuclear localization and membrane transport. CK1 isoforms also have key roles in the

developmentally important Wnt and Hedgehog (Hh) signaling pathways. When Wnt is not bound to its receptor,

CK1alpha is thought to phosphorylate beta-catenin as part of its degradation process. Upon binding of Wnt to

its receptor (Frizzled) CK1epsilon phosphorylates the intracellular signaling protein, Dishevelled and

CK1gamma directly phosphorylates the LRP5/6 co-receptor. These actions of CK1 facilitate signal transduction

to the transcription factor, TCF, which mediates transcription of Wnt regulated genes. Similarly, CK1alpha

plays a role in regulating Hh signaling by phosphorylating the signaling effector Ci-155 in the Hh unbound

state, and then when Hh binds to Patched, CK1alpha phosphorylates the 7-TM co-receptor, Smoothened.

Gene Wiki entry for CSNK1A1 (Casein kinase 1, alpha 1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_029289.11

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CSNK1A1 gene promoter:
STAT1 AML1a p300 Lmo2 LUN-1 Evi-1 Egr-2 CREB FAC1 Sox9
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CSNK1A1 promoter sequence

Search SABiosciences Chromatin IP Primers for CSNK1A1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CSNK1A1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q32 Ensembl cytogenetic band: 5q32 HGNC cytogenetic band: 5q32

CSNK1A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CSNK1A1 gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M148854: view genomic region (about GC identifiers)

Start:	148,871,760 bp from pter	End:	148,931,007 bp from pter
Size:	59,248 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: KC1A_HUMAN, P48729 (See protein sequence)

Recommended Name: Casein kinase I isoform alpha

Size: 337 amino acids; 38915 Da

Subunit: Monomer. Interacts with the Axin complex. Interacts with TUT1, leading to TUT1 phosphorylation

Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton, centrosome. Chromosome, centromere, kinetochore. Nucleus

speckle. Note=Localizes to the centrosome in interphase cells, and to kinetochore fibers during mitosis

Secondary accessions: D3DQG0 D3DQG1 Q4JJA0 Q5U046 Q5U047 Q6FGA2 Q96HD2 Q9UDK3

Alternative splicing: 2 isoforms: P48729-1 P48729-2 (Contains a phosphoserine at position 156)

Explore the universe of human proteins at neXtProt for CSNK1A1: NX_P48729

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P48729

4/21 DME Specific Peptides for CSNK1A1 (P48729) (see all 21)

QGGVGIP

ESKLYKI

PDNFLMG

WYGQEKD

CSNK1A1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_001020276.1 NP_001258670.1 NP_001258671.1 NP_001883.4

ENSEMBL proteins:

ENSP00000261798 ENSP00000426747 ENSP00000427031 ENSP00000421689 ENSP00000425366

ENSP00000430252 ENSP00000421268 ENSP00000367074 ENSP00000385776

Reactome Protein details: P48729
Human Recombinant Protein Products:

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	Browse Proteins at Uscn

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000777	condensed chromosome kinetochore	IEA	--
GO:0005813	centrosome	IDA	--
GO:0005829	cytosol	TAS	--
GO:0005847	colocalizes with mRNA cleavage and polyadenylation specificity factor complex	IDA	18305108
GO:0016607	nuclear speck	IDA	18305108

CSNK1A1 for ontologies About GeneDecksing

CSNK1A1 Antibody Products:

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CSNK1A1 for domains About GeneDecksing

4 InterPro domains/families:

IPR017441 Protein_kinase_ATP_BS

IPR011009 Kinase-like_dom

IPR008271 Ser/Thr_kinase_AS

IPR000719 Prot_kinase_cat_dom

Graphical View of Domain Structure for InterPro Entry P48729

ProtoNet protein and cluster: P48729

UniProtKB/Swiss-Prot: KC1A_HUMAN, P48729

Similarity: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily

Similarity: Contains 1 protein kinase domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: KC1A_HUMAN, P48729

Function: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins

as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1

at 'Ser-45'. May play a role in segregating chromosomes during mitosis

Catalytic activity: ATP + a protein = ADP + a phosphoprotein

Genatlas biochemistry entry for CSNK1A1:

casein kinase I,catalytic unit,alpha 1,involved in the transduction of WNT signal

Enzyme Number (IUBMB): EC 2.7.11.1¹ ²

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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSNK1A1

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004672	protein kinase activity	TAS	10777483
GO:0004674	protein serine/threonine kinase activity	IDA	18305108
GO:0005515	protein binding	IPI	--
GO:0005524	ATP binding	IEA	--

CSNK1A1 for ontologies About GeneDecksing

9 GenomeRNAi human phenotypes for CSNK1A1:

Decreased cilium length after	Decreased focal adhesion (FA)	Decreased homologous recombina	Decreased substrate adherent c
Increased cell death in HCT116	Increased circadian period len	Increased viability with 4OH t	Upregulation of Wnt/beta-caten
Wnt reporter downregulated

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/22 super-pathways (see all 22) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Ubiquitinated Orc1 is degraded by the proteasome

	Degradation of beta-catenin by the destruction complex	0.72			Degradation of ubiquitinated -beta catenin by the proteasome	0.72
	Signaling by Wnt	0.72

Wnt Signaling Pathway

	Wnt Signaling Pathway	0.33			Wnt Signaling Pathway NetPath	0.22
	Wnt signaling pathway	0.30

Basal cell carcinoma

Hedgehog signaling pathway

0.41

Wnt Pathway

0.37

Development_CNTF receptor signaling

Translation _Regulation of EIF2 activity

0.25

Translation Regulation activity of EIF2

0.25

Wnt / Hedgehog / Notch

Wnt / Hedgehog / Notch

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for CSNK1A1

Translation Regulation activity of EIF2

1 R&D Systems Pathway for CSNK1A1

Wnt Signaling Pathway

5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CSNK1A1 (see all 6)

	GSK3 Signaling
	NFAT and Cardiac Hypertrophy
	Signaling in Gap Junctions
	WNT Signaling
	Dopamine-DARPP32 Feedback onto cAMP Pathway

2 Cell Signaling Technology (CST) Pathways for CSNK1A1

	Wnt / Hedgehog / Notch
	DNA Damage

2 Tocris Bioscience Pathways for CSNK1A1

	Hedgehog Pathway
	Wnt Pathway

1 GeneGo (Thomson Reuters) Pathway for CSNK1A1

Translation Regulation of EIF2 activity

5/8 BioSystems Pathways for CSNK1A1 (see all 8)

	Wnt Signaling Pathway NetPath
	FoxO family signaling
	Role of Calcineurin-dependent NFAT signaling in lymphocytes
	Hedgehog signaling events mediated by Gli proteins
	Noncanonical Wnt signaling pathway

5 Reactome Pathways for CSNK1A1

	Signaling by Wnt
	Signal Transduction
	Beta-catenin phosphorylation cascade
	Degradation of beta-catenin by the destruction complex
	Degradation of ubiquitinated -beta catenin by the proteasome

2 Kegg Pathways (Kegg details for CSNK1A1):

	Wnt signaling pathway
	Hedgehog signaling pathway

CSNK1A1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CSNK1A1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/169 Interacting proteins for CSNK1A1 (P48729^{1, 2, 3} ENSP00000261798⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 169)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RCC1	P18754²^,³, ENSP00000362937⁴	MINT-14931 MINT-15051 MINT-14932 I2D: score=4 STRING: ENSP00000362937
MDM2	Q00987¹^,³, ENSP00000417281⁴	EBI-1383726,EBI-389668 I2D: score=2 STRING: ENSP00000417281
KPNA1	P52294²^,³, ENSP00000343701⁴	MINT-15348 I2D: score=1 STRING: ENSP00000343701
SYT11	Q9BT88²^,³, ENSP00000357307⁴	MINT-17245 I2D: score=1 STRING: ENSP00000357307
MDM4	O15151²^,³, ENSP00000356150⁴	MINT-1958437 MINT-3391176 I2D: score=3 STRING: ENSP00000356150

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000902	cell morphogenesis	--	--
GO:0006468	protein phosphorylation	IDA	18305108
GO:0007067	mitosis	IEA	--
GO:0007165	signal transduction	NAS	10777483
GO:0007166	cell surface receptor signaling pathway	TAS	10777483

CSNK1A1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CSNK1A1 for compounds About GeneDecksing

EMD Millipore small molecules for CSNK1A1:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Compounds for CSNK1A1 available from Tocris Bioscience About this table

Compound	Action	CAS #
(R)-DRF053 dihydrochloride	Dual CK1/cdk inhibitor	[1056016-06-8]
D 4476	Selective CK1 inhibitor. Also inhibits TGF-betaRI	[301836-43-1]

2 HMDB Compounds for CSNK1A1 About this table

Compound	Synonyms	CAS #	PubMed Ids
ADP	adenosindiphosphorsaeure (see all 8)	58-64-0	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--

4 Novoseek chemical compound relationships for CSNK1A1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
threonine	41.9	1	15722192 (1)
glycogen	41.6	6	17172446 (1), 15747065 (1), 15327768 (1), 19293931 (1) (see all 5)
serine	37.8	1	15722192 (1)
tyrosine	0	2	17172446 (1)

Search CenterWatch for drugs/clinical trials and news about CSNK1A1 / KC1A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CSNK1A1 gene (4 alternative transcripts):

NM_001025105.2 NM_001271741.1 NM_001271742.1 NM_001892.5

Unigene Clusters for CSNK1A1:

Casein kinase 1, alpha 1

Hs.529862 [show with all ESTs], Hs.712555 [show with all ESTs]

Unigene Representative Sequences: BX647478, NM_001025105

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000261798 ENST00000504676 ENST00000515435 ENST00000515768 ENST00000503350

ENST00000523203 ENST00000515748 ENST00000377843(uc011dcb.1 uc011dcc.2 uc003lqw.1 uc003lqx.1 uc003lqy.1 uc010jha.1)

ENST00000322237

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Additional cDNA sequence:

AF218004.1 AK293761.1 AK294099.1 AK294942.1 AK303794.1 BC007246.1 BC008717.2 BC009186.2

BC020446.2 BC021971.2 BC025371.2 BC105984.1 BT019829.1 BT019830.1 CR542206.1 DQ082865.1

L37042.1 X80693.1

24/40 DOTS entries (see all 40):

DT.452922 DT.95165500 DT.92391794 DT.100861115 DT.101969880 DT.100861109 DT.97862239 DT.100861111

DT.120841084 DT.95165508 DT.99950970 DT.120840993 DT.86859564 DT.100754768 DT.100806837 DT.120790922

DT.95266235 DT.99935057 DT.95165465 DT.100038876 DT.100861108 DT.121081702 DT.95116597 DT.100744907

24/837 AceView cDNA sequences (see all 837):

BM673489 CD106962 AA890557 BM698900 AI475496 BP365743 AI422709 BM832475

BP349247 AI630480 CN479199 CR602716 BU849621 CB242140 CB529587 BQ425531

AA468842 AL701490 CB122490 BQ006699 CA842800 BQ018255 AA974037 BE645997

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CSNK1A1 (see all 8) About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	·	2c	^	3a	·	3b	·	3c	·	3d	^	4	^	5	^	6	^	7	^	8	^	9a	·	9b	^	10	^	11	^	12	^	13	^	14	^	15	^	16
SP1:													-		-						-		-						-														-		-
SP2:													-		-						-		-
SP3:																					-		-
SP4:																					-		-						-
SP5:							-						-		-

ECgene alternative splicing isoforms for CSNK1A1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CSNK1A1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATGTATGTT

About this image
See CSNK1A1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CSNK1A1

SOURCE GeneReport for Unigene clusters: Hs.529862 Hs.712555

SABiosciences Expression via Pathway-Focused PCR Arrays including CSNK1A1:

Hedgehog Signaling Pathway in human mouse rat

WNT Signaling Pathway in human mouse rat

Circadian Rhythms in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for CSNK1A1 gene from 9/29 species (see all 29) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Csnk1a1^{1 , 5}	casein kinase 1, alpha 1^{1, 5}	94.65(n)¹ 100(a)¹		18 (34.62 cM)⁵ 93687¹ NM_146087.2¹ NP_666199.1¹ 61555274⁵
chicken (Gallus gallus)	Aves	CSNK1A1¹	casein kinase 1, alpha 1	90.5(n) 99.73(a)		395924 NM_205053.1 NP_990384.1
lizard (Anolis carolinensis)	Reptilia	--	--	99(a)	1 → many	2(122539011-122574549)
African clawed frog (Xenopus laevis)	Amphibia	MGC68433²	hypothetical protein MGC68433	83.25(n)		BC057701.1
zebrafish (Danio rerio)	Actinopterygii	csnk1a1²	casein kinase 1, alpha 1	82.52(n)		192307 AF516328.1
fruit fly (Drosophila melanogaster)	Insecta	CkIalpha^{1 , 3}	DNA repair protein kinase³ Casein kinase Ialpha¹	76(a) (best of 6)³ 67.81(n)¹ 78.57(a)¹		1 11B7³ 32221¹ NM_001169266.2¹ NP_001162737.1¹
worm (Caenorhabditis elegans)	Secernentea	kin-19⁶	Casein kinase I isoform alpha	79(a)	1 → many	III(4084010-4086618)
thale cress (Arabidopsis thaliana)	eudicotyledons	ckl8¹	casein kinase I-like 8	61.52(n) 68.81(a)		834350 NM_123698.3 NP_199146.1
rice (Oryza sativa)	Liliopsida	Os10g0476300¹	hypothetical protein	64.62(n) 68.94(a)		4348890 NM_001071382.1 NP_001064847.1

ENSEMBL Gene Tree for CSNK1A1 (if available)
TreeFam Gene Tree for CSNK1A1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for CSNK1A1 gene

VRK3² VRK1² CSNK1G3² VRK2² CSNK1D² CSNK1G2² CSNK1A1L² TTBK1²

CSNK1G1² CSNK1E² TTBK2²

10 SIMAP similar genes for CSNK1A1 using alignment to 9 protein entries: KC1A_HUMAN (see all proteins):

CSNK1A1L CSNK1E CSNK1D CSNK2A2 CSNK1G1 CSNK1G2

CSNK1G3 TTBK2 TTBK1 VRK1

CSNK1A1 for paralogs About GeneDecksing

5 Pseudogenes.org Pseudogenes for CSNK1A1
PGOHUM00000242443 PGOHUM00000251178 PGOHUM00000235710 PGOHUM00000250924 PGOHUM00000250925

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs184426672^1,2		--	148874364(+)	`TTAATA/TACAGA`	2	--	ds500¹		0	--	--	--	--
rs12054686^1,2	C,F,H,	--	148874387(+)	`CAACCT/GTTTCA`	2	--	ds500¹		10		NS EA	1424
rs150274068^1,2		--	148874765(+)	`TAAAGC/TAGTTT`	2	--	ds500¹		0	--	--	--	--
rs75736516^1,2		--	148874833(+)	`AAACAC/TGTGTC`	2	--	ds500¹		0	--	--	--	--
rs80170458^1,2	C,	--	148874837(+)	`ACGTGG/TCAATT`	2	--	ds500¹		0	--	--	--	--
rs1056344^1,2	C,F,	--	148874928(-)	`CAGGAT/GAAATT`	2	--	ut3¹		2		MN NA	304
rs11167469^1,2	C,F,H,	--	148874971(-)	`ATGATA/TATTTT`	6	--	int¹ ut3¹		5		NS EA	510
rs138921414^1,2		--	148875044(+)	`GGAAGC/TGCACG`	6	--	int¹ ut3¹		0	--	--	--	--
rs7728306^1,2	C,F,H,	--	148875124(+)	`ATGCTC/ATCCAA`	6	--	ut3¹ int¹		7		NS EA NA	906
rs200358530^1,2	C	--	148875307(+)	`AGTCAA/TAAAAA`	6	--	ut3¹ int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CSNK1A1 (148871760 - 148931007 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for CSNK1A1
2 CNVs: 69218 51591
1 Indel: 99321

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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CSNK1A1 for disorders           About GeneDecksing

OMIM gene information: 600505    OMIM disorders: --

20 diseases for CSNK1A1:    About MalaCards

familial adenomatous polyposis lung cancer duchenne muscular dystrophy muscular dystrophy

esophageal squamous cell carcinoma squamous cell carcinoma syringoma polyposis

paine syndrome hepatitis c skin cancer alzheimer's disease

esophagitis lung carcinoma meningioma neuropathy

carcinoma hepatitis malaria adenomatous polyposis coli

2 Novoseek disease relationships for CSNK1A1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
familial adenomatous polyposis	33.6	1	15747065 (1)
cancer	26.8	4	20350806 (1), 15747065 (1), 15722192 (1)

Human Genome Epidemiology (HuGE) Navigator: CSNK1A1 (3 documents)

Export disorders for CSNK1A1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CSNK1A1 gene, integrated from 9 sources (see all 130):
(articles sorted by number of sources associating them with CSNK1A1)

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Cloning and chromosomal localization of the gene coding for human protein kinase CK1. (PubMed id 8050587)^{1, 2, 3} Tapia C....Allende J.E. (1994)
CKIalpha is associated with and phosphorylates star-PAP and is also required for expression of select star-PAP target messenger RNAs. (PubMed id 18305108)^{1, 2} Gonzales M.L....Anderson R.A. (2008)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism. (PubMed id 11955436)^{1, 2} Liu C.... He X. (2002)
Isolation and characterization of human casein kinase I epsilon (CKI), a novel member of the CKI gene family. (PubMed id 7797465)^{1, 2} Fish K.J.... Virshup D.M. (1995)
Cell cycle-dependent localization of casein kinase I to mitotic spindles. (PubMed id 1409656)^{1, 2} Brockman J.L.... Anderson R.A. (1992)
Phosphorylation of the proteins of the extracellular matrix of mineralized tissues by casein kinase-like activity. (PubMed id 9391750)^{1, 9} Veis A....Wu C.B. (1997)
Casein kinase I associates with members of the centaurin-alpha family of phosphatidylinositol 3,4,5-trisphosphate-binding proteins. (PubMed id 11278595)^{1, 9} Dubois T....Aitken A. (2001)
Casein kinase-1 phosphorylates the p75 tumor necrosis factor receptor and negatively regulates tumor necrosis factor signaling for apoptosis. (PubMed id 7559483)^{1, 9} Beyaert R....Fiers W. (1995)
Mammalian casein kinase 1alpha and its leishmanial or tholog regulate stability of IFNAR1 and type I interferon signaling. (PubMed id 19805514)^{1, 9} Liu J....Fuchs S.Y. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1452	HGNC: 2451	AceView: CSNK1A1	Ensembl:ENSG00000113712	euGenes: HUgn1452
ECgene: CSNK1A1	Kegg: 1452	H-InvDB: CSNK1A1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CSNK1A1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CSNK1A1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for CSNK1A1 gene
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Patent Information for CSNK1A1 gene:
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CSNK1A1 Gene

casein kinase 1, alpha 1

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CSNK1A1 Gene

casein kinase 1, alpha 1

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