Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CSNK1A1 Gene

protein-coding   GIFtS: 70
GCID: GC05M148854

Casein Kinase 1, Alpha 1

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Casein Kinase 1, Alpha 11 2     CKIa2
Clock Regulator Kinase1 2     HLCDGP12
CK12 3     PRO29752
CKI-alpha2 3     Casein Kinase I Isoform Alpha2
EC 2.7.11.13 8     Down-Regulated In Lung Cancer2
CK1a2     

External Ids:    HGNC: 24511   Entrez Gene: 14522   Ensembl: ENSG000001137127   OMIM: 6005055   UniProtKB: P487293   

Export aliases for CSNK1A1 gene to outside databases

Previous GC identifers: GC05M148919 GC05M149467 GC05M148904 GC05M148902 GC05M144021


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CSNK1A1 Gene: 
CSNK1A1 (casein kinase 1, alpha 1) is a protein-coding gene. Diseases associated with CSNK1A1 include syringoma, and familial adenomatous polyposis, and among its related super-pathways are Wnt signaling pathway and Basal cell carcinoma. GO annotations related to this gene include protein serine/threonine kinase activity and protein kinase activity. An important paralog of this gene is VRK3.

UniProtKB/Swiss-Prot: KC1A_HUMAN, P48729
Function: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as
caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling.
Phosphorylates CTNNB1 at 'Ser-45'. May play a role in segregating chromosomes during mitosis

summary for CSNK1A1 Gene:
Casein kinase I (CK1) is a monomeric serine-threonine protein kinase with 7 isoforms: alpha, beta, gamma1,
gamma2, gamma3, delta and epsilon. CK1 is involved in a number of cellular processes including DNA repair,
cell division, nuclear localization and membrane transport. CK1 isoforms also have key roles in the
developmentally important Wnt and Hedgehog (Hh) signaling pathways. When Wnt is not bound to its receptor,
CK1alpha is thought to phosphorylate beta-catenin as part of its degradation process. Upon binding of Wnt to
its receptor (Frizzled) CK1epsilon phosphorylates the intracellular signaling protein, Dishevelled and
CK1gamma directly phosphorylates the LRP5/6 co-receptor. These actions of CK1 facilitate signal transduction
to the transcription factor, TCF, which mediates transcription of Wnt regulated genes. Similarly, CK1alpha
plays a role in regulating Hh signaling by phosphorylating the signaling effector Ci-155 in the Hh unbound
state, and then when Hh binds to Patched, CK1alpha phosphorylates the 7-TM co-receptor, Smoothened.

Gene Wiki entry for CSNK1A1 (Casein kinase 1, alpha 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_029289.11  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CSNK1A1 gene promoter:
         STAT1   AML1a   p300   Lmo2   LUN-1   Evi-1   Egr-2   CREB   FAC1   Sox9   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCSNK1A1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CSNK1A1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CSNK1A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q32   Ensembl cytogenetic band:  5q32   HGNC cytogenetic band: 5q32

CSNK1A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CSNK1A1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M148854:  view genomic region     (about GC identifiers)

Start:
148,871,760 bp from pter      End:
148,931,007 bp from pter
Size:
59,248 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KC1A_HUMAN, P48729 (See protein sequence)
Recommended Name: Casein kinase I isoform alpha  
Size: 337 amino acids; 38915 Da
Subunit: Monomer. Interacts with the Axin complex. Interacts with TUT1, leading to TUT1 phosphorylation
Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome,
centromere, kinetochore. Nucleus speckle. Note=Localizes to the centrosome in interphase cells, and to
kinetochore fibers during mitosis
Secondary accessions: D3DQG0 D3DQG1 Q4JJA0 Q5U046 Q5U047 Q6FGA2 Q96HD2 Q9UDK3
Alternative splicing: 2 isoforms:  P48729-1   P48729-2   (Contains a phosphoserine at position 156)

Explore the universe of human proteins at neXtProt for CSNK1A1: NX_P48729

Explore proteomics data for CSNK1A1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P48729

  • 4/21 DME Specific Peptides for CSNK1A1 (P48729) (see all 21)
     QGGVGIP  ESKLYKI  PDNFLMG  WYGQEKD 

    CSNK1A1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CSNK1A1 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001020276.1  NP_001258670.1  NP_001258671.1  NP_001883.4  

    ENSEMBL proteins: 
     ENSP00000261798   ENSP00000426747   ENSP00000427031   ENSP00000475319   ENSP00000421689  
     ENSP00000475969   ENSP00000425366   ENSP00000475633   ENSP00000430252   ENSP00000421268  
     ENSP00000367074  
    Reactome Protein details: P48729
    Human Recombinant Protein Products for CSNK1A1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CSNK1A1
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CSNK1A1
    GenScript Custom Purified and Recombinant Proteins Services for CSNK1A1
    Novus Biologicals CSNK1A1 Proteins
    Novus Biologicals CSNK1A1 Lysate
    Sino Biological Recombinant Protein for CSNK1A1
    Sino Biological Cell Lysate for CSNK1A1 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000777condensed chromosome kinetochore IEA--
    GO:0005813centrosome IDA--
    GO:0005829cytosol TAS--
    GO:0005847colocalizes with mRNA cleavage and polyadenylation specificity factor complex IDA18305108
    GO:0016607nuclear speck IDA18305108

    CSNK1A1 for ontologies           About GeneDecksing



    CSNK1A1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CSNK1A1 (Casein Kinase 1 alpha)
    Cell Signaling Technology (CST) Antibodies for CSNK1A1  (CK1A)
    OriGene Antibodies for CSNK1A1
    OriGene Custom Antibody Services for CSNK1A1
    GenScript Superior Antibodies for CSNK1A1
    Novus Biologicals CSNK1A1 Antibodies
    Abcam antibodies for CSNK1A1
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for CSNK1A1
    LSBio Antibodies in human, mouse, rat for CSNK1A1 

    Assay Products for CSNK1A1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CSNK1A1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CSNK1A1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: casein kinase 1, alpha 1 
    Casein kinase 1 (CK1) family

    4 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry P48729

    ProtoNet protein and cluster: P48729

    UniProtKB/Swiss-Prot: KC1A_HUMAN, P48729
    Similarity: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I
    subfamily
    Similarity: Contains 1 protein kinase domain


    CSNK1A1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KC1A_HUMAN, P48729
    Function: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as
    caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling.
    Phosphorylates CTNNB1 at 'Ser-45'. May play a role in segregating chromosomes during mitosis
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Genatlas biochemistry entry for CSNK1A1:
    casein kinase I,catalytic unit,alpha 1,involved in the transduction of WNT signal

         Enzyme Number (IUBMB): EC 2.7.11.11 2

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity TAS10777483
    GO:0004674protein serine/threonine kinase activity IDA18305108
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI16511560
    GO:0005524ATP binding IEA--
         
    CSNK1A1 for ontologies           About GeneDecksing


    Phenotypes:
         9 GenomeRNAi human phenotypes for CSNK1A1:
     Decreased cilium length after   Decreased focal adhesion (FA)   Decreased homologous recombina  Decreased substrate adherent c 
     Increased cell death in HCT116  Increased circadian period len  Increased viability with 4OH t  Upregulation of Wnt/beta-caten 
     Wnt reporter downregulated 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CSNK1A1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CSNK1A1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CSNK1A1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CSNK1A1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CSNK1A1
    8/53 QIAGEN miScript miRNA Assays for microRNAs that regulate CSNK1A1 (see all 53):
    hsa-miR-576-3p hsa-miR-3678-3p hsa-miR-4307 hsa-miR-605 hsa-miR-30d hsa-miR-628-3p hsa-miR-502-3p hsa-miR-4275
    SwitchGear 3'UTR luciferase reporter plasmidCSNK1A1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CSNK1A1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CSNK1A1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CSNK1A1
    Sirion Biotech Customized adenovirus for overexpression of CSNK1A1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CSNK1A1 (see all 14)
    OriGene ORF clones in mouse, rat for CSNK1A1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CSNK1A1 (NM_001892)
    Sino Biological Human cDNA Clone for CSNK1A1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CSNK1A1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSNK1A1
    Sirion Biotech Customized lentivirus for stable overexpression of CSNK1A1 
                         Customized lentivirus expression plasmids for stable overexpression of CSNK1A1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CSNK1A1
    Search LifeMap BioReagents cell lines for CSNK1A1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSNK1A1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CSNK1A1 About   (see all 24)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Wnt signaling pathway
    Wnt signaling pathway0.40
    Wnt Signaling Pathway NetPath0.37
    Wnt Signaling Pathway0.40
    2Basal cell carcinoma
    Hedgehog signaling pathway0.43
    Wnt Pathway0.39
    3Canonical Wnt Pathway
    Non-Canonical Wnt Pathway0.53
    Canonical Wnt Pathway0.53
    4CDK-mediated phosphorylation and removal of Cdc6
    Degradation of beta-catenin by the destruction complex0.75
    5Asparagine N-linked glycosylation
    Signaling by Wnt0.62

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for CSNK1A1
        Translation Regulation activity of EIF2

    1 R&D Systems Pathway for CSNK1A1
        Wnt Signaling Pathway

    5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CSNK1A1 (see all 6)
        GSK3 Signaling
    NFAT and Cardiac Hypertrophy
    Signaling in Gap Junctions
    WNT Signaling
    Dopamine-DARPP32 Feedback onto cAMP Pathway

    2 Cell Signaling Technology (CST) Pathways for CSNK1A1
        Wnt / Hedgehog / Notch
    DNA Damage

    2 Tocris Bioscience Pathways for CSNK1A1
        Hedgehog Pathway
    Wnt Pathway

    1 GeneGo (Thomson Reuters) Pathway for CSNK1A1
        Translation Regulation of EIF2 activity

    5/8 BioSystems Pathways for CSNK1A1 (see all 8)
        Wnt Signaling Pathway NetPath
    Canonical Wnt signaling pathway
    FoxO family signaling
    p53 pathway
    Hedgehog signaling events mediated by Gli proteins

    2 Sino Biological Pathways for CSNK1A1 
        Canonical Wnt Pathway
    Non-Canonical Wnt Pathway

    4        Reactome Pathways for CSNK1A1
        Signaling by Wnt
    Signal Transduction
    Beta-catenin phosphorylation cascade
    Degradation of beta-catenin by the destruction complex


    2         Kegg Pathways  (Kegg details for CSNK1A1):
        Wnt signaling pathway
    Hedgehog signaling pathway


    CSNK1A1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CSNK1A1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/170 Interacting proteins for CSNK1A1 (P487291, 2, 3 ENSP000002617984) via UniProtKB, MINT, STRING, and/or I2D (see all 170)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RCC1P187542, 3, ENSP000003629374MINT-14931 MINT-15051 MINT-14932 I2D: score=4 STRING: ENSP00000362937
    MDM2Q009871, 3, ENSP000004172814EBI-2040168,EBI-389668 I2D: score=2 STRING: ENSP00000417281
    KPNA1P522942, 3, ENSP000003437014MINT-15348 I2D: score=1 STRING: ENSP00000343701
    SYT11Q9BT882, 3, ENSP000003573074MINT-17245 I2D: score=1 STRING: ENSP00000357307
    MDM4O151512, 3, ENSP000003561504MINT-1958437 MINT-3391176 I2D: score=3 STRING: ENSP00000356150
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation IDA18305108
    GO:0007067mitosis IEA--
    GO:0007165signal transduction NAS10777483
    GO:0007166cell surface receptor signaling pathway TAS10777483
    GO:0016055Wnt receptor signaling pathway IEA--

    CSNK1A1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CSNK1A1 for compounds           About GeneDecksing

    EMD Millipore small molecules for CSNK1A1:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for CSNK1A1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    PF 4800567 hydrochlorideSelective casein kinase 1epsilon inhibitor[1188296-52-7]
    D 4476Selective CK1 inhibitor. Also inhibits TGF-betaRI[301836-43-1]
    (R)-DRF053 dihydrochlorideDual CK1/cdk inhibitor[1056016-06-8]
    TAK 715Potent p38 MAPK inhibitor; anti-inflammatory[303162-79-0]
    PF 670462Potent and selective CK1epsilon and CK1delta inhibitor[950912-80-8]

    2 HMDB Compounds for CSNK1A1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    4 Novoseek inferred chemical compound relationships for CSNK1A1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 41.9 1 15722192 (1)
    glycogen 41.6 6 17172446 (1), 15747065 (1), 15327768 (1), 19293931 (1) (see all 5)
    serine 37.8 1 15722192 (1)
    tyrosine 0 2 17172446 (1)

    Search CenterWatch for drugs/clinical trials and news about CSNK1A1 / KC1A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CSNK1A1 gene (4 alternative transcripts): 
    NM_001025105.2  NM_001271741.1  NM_001271742.1  NM_001892.5  

    Unigene Clusters for CSNK1A1:

    Casein kinase 1, alpha 1
    Hs.529862  [show with all ESTs], Hs.712555  [show with all ESTs]
    Unigene Representative Sequences: BX647478, NM_001025105
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261798 ENST00000504676 ENST00000515435 ENST00000606719 ENST00000515768
    ENST00000606826 ENST00000503350 ENST00000606299 ENST00000523203 ENST00000515748
    ENST00000377843(uc011dcb.1 uc011dcc.2 uc003lqw.1 uc003lqx.1 uc003lqy.1 uc010jha.1)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CSNK1A1
    8/53 QIAGEN miScript miRNA Assays for microRNAs that regulate CSNK1A1 (see all 53):
    hsa-miR-576-3p hsa-miR-3678-3p hsa-miR-4307 hsa-miR-605 hsa-miR-30d hsa-miR-628-3p hsa-miR-502-3p hsa-miR-4275
    SwitchGear 3'UTR luciferase reporter plasmidCSNK1A1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CSNK1A1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CSNK1A1
    Clone
    Products:
         
    OriGene clones in human, mouse for CSNK1A1 (see all 14)
    OriGene ORF clones in mouse, rat for CSNK1A1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CSNK1A1 (NM_001892)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CSNK1A1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSNK1A1
    Sirion Biotech Customized lentivirus for stable overexpression of CSNK1A1 
                         Customized lentivirus expression plasmids for stable overexpression of CSNK1A1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CSNK1A1
    OriGene qSTAR qPCR primer pairs in human, mouse for CSNK1A1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CSNK1A1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CSNK1A1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CSNK1A1

    Additional mRNA sequence: 

    AF218004.1 AK293761.1 AK294099.1 AK294942.1 AK303794.1 BC007246.1 BC008717.2 BC021971.2 
    BC025371.2 BT019829.1 BT019830.1 CR542206.1 DQ082865.1 L37042.1 X80693.1 

    24/40 DOTS entries (see all 40):

    DT.452922  DT.95165500  DT.92391794  DT.100861115  DT.97862239  DT.101969880  DT.100861109  DT.100861111 
    DT.120841084  DT.95165508  DT.99950970  DT.120840993  DT.86859564  DT.100754768  DT.100806837  DT.120790922 
    DT.95266235  DT.99935057  DT.95165465  DT.100038876  DT.100861108  DT.121081702  DT.95116597  DT.100744907 

    24/837 AceView cDNA sequences (see all 837):

    CA441162 CB122490 AI347691 CB117328 BF445868 BF032386 BQ018255 CA419328 
    AA506706 CA842800 BQ720484 AA974037 CA943600 AI338034 AA827408 CA432300 
    AL712151 CR542206 BQ015861 BI712976 AI356545 AI822074 AA987305 BX284079 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CSNK1A1 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
    SP1:                                      -     -                 -     -                 -                                         -     -         
    SP2:                                      -     -                 -     -                                                                           
    SP3:                                                              -     -                                                                           
    SP4:                                                              -     -                 -                                                         
    SP5:                    -                 -     -                                                                                                   


    ECgene alternative splicing isoforms for CSNK1A1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CSNK1A1 expression in normal human tissues (normalized intensities)      CSNK1A1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATGTATGTT
    CSNK1A1 Expression
    About this image


    CSNK1A1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/25 selected tissues (see all 25) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
     
     Lung (Respiratory System)    fully expand to see all 3 entries
             bronchus ; respiratory epithelial cells   
             trachea   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Hippocampus

    See CSNK1A1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CSNK1A1

    SOURCE GeneReport for Unigene clusters: Hs.529862 Hs.712555
        SABiosciences Expression via Pathway-Focused PCR Arrays including CSNK1A1: 
              Hedgehog Signaling Pathway in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Circadian Rhythms in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CSNK1A1
    OriGene qSTAR qPCR primer pairs in human, mouse for CSNK1A1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CSNK1A1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CSNK1A1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CSNK1A1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSNK1A1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CSNK1A1 gene from 10/20 species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Csnk1a11 , 5 casein kinase 1, alpha 11, 5 94.65(n)1
    100(a)1
      18 (34.62 cM)5
    936871  NM_146087.21  NP_666199.11 
     615552745 
    chicken
    (Gallus gallus)
    Aves CSNK1A11 casein kinase 1, alpha 1 90.5(n)
    99.73(a)
      395924  NM_205053.1  NP_990384.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    100(a)
    possible ortholog
    2(122538154-122589927)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC684332 hypothetical protein MGC68433 83.25(n)    BC057701.1 
    zebrafish
    (Danio rerio)
    Actinopterygii csnk1a12 casein kinase 1, alpha 1 82.52(n)   192307  AF516328.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CkIalpha1 , 3 DNA repair protein kinase3
    Casein kinase Ialpha1
    76(a)
    (best of 6)3
    67.81(n)1
    78.57(a)1
      1 11B73
    322211  NM_001169266.21  NP_001162737.11 
    worm
    (Caenorhabditis elegans)
    Secernentea kin-196
    Casein kinase I isoform alpha
    81(a)
    1 → many
    III(4084035-4086643)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HRR256
    Protein kinase involved in regulating diverse even...
    40(a)
    1 → many
    XVI(164276-165760)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ckl81 casein kinase I-like 8 61.52(n)
    68.81(a)
      834350  NM_123698.3  NP_199146.1 
    rice
    (Oryza sativa)
    Liliopsida Os10g04763001 hypothetical protein 64.62(n)
    68.94(a)
      4348890  NM_001071382.1  NP_001064847.1 


    ENSEMBL Gene Tree for CSNK1A1 (if available)
    TreeFam Gene Tree for CSNK1A1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CSNK1A1 gene
    VRK32  VRK12  CSNK1G32  VRK22  CSNK1D2  ENSG000002593162  CSNK1G22  CSNK1A1L2  
    TTBK12  CSNK1E2  CSNK1G12  TTBK22  
    11 SIMAP similar genes for CSNK1A1 using alignment to 9 protein entries:     KC1A_HUMAN (see all proteins):
    CSNK1A1L    CSNK1E    CSNK1D    CSNK2A2    CSNK1G1    CSNK2A3
    CSNK1G2    CSNK1G3    TTBK2    TTBK1    VRK1

    CSNK1A1 for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for CSNK1A1
    PGOHUM00000242443 PGOHUM00000251178 PGOHUM00000235710 PGOHUM00000250924 PGOHUM00000250925


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1084 SNPs in CSNK1A1 are shown (see all 1084)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0420734
    A breast pleomorphic lobular carcinoma sample4--see VAR_0420732 D H mis40--------
    rs580054311,2
    C--144060398(+) AAAAA-/AA/A  
     AA
    /AAAA
    GAAGG
    6 -- int11NA 2
    rs1844266721,2
    --148874364(+) TTAATA/TACAGA 2 -- ds50010--------
    rs120546861,2
    C,F,H--148874387(+) CAACCT/GTTTCA 2 -- ds500110Minor allele frequency- G:0.14NS EA 1424
    rs1502740681,2
    --148874765(+) TAAAGC/TAGTTT 2 -- ds50010--------
    rs757365161,2
    --148874833(+) AAACAC/TGTGTC 2 -- ds50010--------
    rs801704581,2
    C--148874837(+) ACGTGG/TCAATT 2 -- ds50010--------
    rs10563441,2
    C,F--148874928(-) CAGGAT/GAAATT 2 -- ut312Minor allele frequency- G:0.04MN NA 304
    rs111674691,2
    C,F,H--148874971(-) ATGATA/TATTTT 6 -- ut31 int15Minor allele frequency- T:0.05NS EA 510
    rs1389214141,2
    C--148875044(+) GGAAGC/TGCACG 6 -- ut31 int10--------

    HapMap Linkage Disequilibrium report for CSNK1A1 (148871760 - 148931007 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for CSNK1A1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2730908CNV Deletion23290073
    nsv5059CNV Insertion18451855
    esv2585670CNV Insertion19546169
    nsv518039CNV Gain19592680
    esv24490CNV Gain19812545
    nsv516848CNV Gain19592680

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CSNK1A1
    DNA2.0 Custom Variant and Variant Library Synthesis for CSNK1A1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600505    OMIM disorders: --

    17 diseases for CSNK1A1:    About MalaCards
    syringoma    familial adenomatous polyposis    duchenne muscular dystrophy    lung cancer
    paine syndrome    liposarcoma    muscular dystrophy    esophageal squamous cell carcinoma
    meningioma    neuropathy    oral squamous cell carcinoma    esophagitis
    hepatitis c    squamous cell carcinoma    parkinson's disease    alzheimer's disease
    hepatitis


    CSNK1A1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    2 Novoseek inferred disease relationships for CSNK1A1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    familial adenomatous polyposis 33.6 1 15747065 (1)
    cancer 26.8 4 20350806 (1), 15747065 (1), 15722192 (1)

    Genetic Association Database (GAD): CSNK1A1
    Human Genome Epidemiology (HuGE) Navigator: CSNK1A1 (3 documents)

    Export disorders for CSNK1A1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CSNK1A1 gene, integrated from 9 sources (see all 144):
    (articles sorted by number of sources associating them with CSNK1A1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and chromosomal localization of the gene coding for human protein kinase CK1. (PubMed id 8050587)1, 2, 3 Tapia C....Allende J.E. (1994)
    2. Genome-wide association study identifies three new su sceptibility loci for esophageal squamous-cell carcinoma in Chinese populations . (PubMed id 21642993)1, 4 Wu C....Lin D. (2011)
    3. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    4. CKIalpha is associated with and phosphorylates star-PAP and is also required for expression of select star-PAP target messenger RNAs. (PubMed id 18305108)1, 2 Gonzales M.L....Anderson R.A. (2008)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism. (PubMed id 11955436)1, 2 Liu C.... He X. (2002)
    7. Isolation and characterization of human casein kinase I epsilon (CKI), a novel member of the CKI gene family. (PubMed id 7797465)1, 2 Fish K.J.... Virshup D.M. (1995)
    8. Cell cycle-dependent localization of casein kinase I to mitotic spindles. (PubMed id 1409656)1, 2 Brockman J.L.... Anderson R.A. (1992)
    9. Phosphorylation of the proteins of the extracellular matrix of mineralized tissues by casein kinase-like activity. (PubMed id 9391750)1, 9 Veis A....Wu C.B. (1997)
    10. Casein kinase I associates with members of the centaurin-alpha family of phosphatidylinositol 3,4,5-trisphosphate-binding proteins. (PubMed id 11278595)1, 9 Dubois T....Aitken A. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1452 HGNC: 2451 AceView: CSNK1A1 Ensembl:ENSG00000113712 euGenes: HUgn1452
    ECgene: CSNK1A1 Kegg: 1452 H-InvDB: CSNK1A1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CSNK1A1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CSNK1A1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CSNK1A1 gene:
    Search GeneIP for patents involving CSNK1A1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
     Browse for Gene Knock-down Tools from EMD Millipore
     EMD Millipore small molecules (inhibitor) for CSNK1A1
     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for CSNK1A1 (Casein Kinase 1 alpha)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for CSNK1A1   OriGene RNAi products in human, mouse, rat for CSNK1A1  
     OriGene qPCR primer pairs and template standards for CSNK1A1   OriGene Protein Over-expression Lysate for CSNK1A1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for CSNK1A1  
     OriGene qSTAR qPCR primer pairs in human, mouse for CSNK1A1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for CSNK1A1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CSNK1A1   OriGene Custom Protein Services for CSNK1A1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CSNK1A1
     QIAGEN SeqTarget long-range PCR primers for resequencing CSNK1A1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CSNK1A1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CSNK1A1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CSNK1A1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CSNK1A1
     GenScript Custom Purified and Recombinant Proteins Services for CSNK1A1 GenScript cDNA clones with any tag delivered in your preferred vector for CSNK1A1
     GenScript Custom Assay Services for CSNK1A1 GenScript Superior Antibodies for CSNK1A1
     GenScript Custom overexpressing Cell Line Services for CSNK1A1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for CSNK1A1  (CK1A)

     Regulatory tfbs in CSNK1A1 promoter
     Search Chromatin IP Primers for CSNK1A1
     RT2 qPCR Primer Assay in human, mouse, rat CSNK1A1
     GNC Network for CSNK1A1
     SABiosciences PCR Arrays including human, mouse, rat CSNK1A1
     Tocris compounds for CSNK1A1
     Proteins and Antibodies for CSNK1A1
     Cell Lysates for CSNK1A1
     cDNA Clones for CSNK1A1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CSNK1A1 antibodies
     CSNK1A1 proteins
     CSNK1A1 lysates
     Antibodies for CSNK1A1
     See all of Abcam's Antibodies, Kits and Proteins for CSNK1A1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for CSNK1A1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSNK1A1
     SwitchGear 3'UTR luciferase reporter plasmids for CSNK1A1
     SwitchGear Promoter luciferase reporter plasmids for CSNK1A1
     ThermoFisher Antibodies for CSNK1A1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSNK1A1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CSNK1A1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CSNK1A1
    Customized:
     lentivirus for stable overexpression of CSNK1A1
     lentivirus expression plasmids for stable overexpression of CSNK1A1
     adenovirus for overexpression of CSNK1A1
     LSBio Antibodies in human, mouse, rat for CSNK1A1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CSNK1A1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4