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Aliases for CSNK1A1 Gene

Aliases for CSNK1A1 Gene

  • Casein Kinase 1 Alpha 1 2 3 5
  • Clock Regulator Kinase 2 3
  • EC 2.7.11.1 4 61
  • CKI-Alpha 3 4
  • CK1 3 4
  • Epididymis Secretory Sperm Binding Protein Li 77p 3
  • Casein Kinase I Isoform Alpha 3
  • Down-Regulated In Lung Cancer 3
  • Casein Kinase 1, Alpha 1 2
  • HEL-S-77p 3
  • HLCDGP1 3
  • PRO2975 3
  • CK1a 3
  • CKIa 3

External Ids for CSNK1A1 Gene

Previous GeneCards Identifiers for CSNK1A1 Gene

  • GC05M148919
  • GC05M148904
  • GC05M148902
  • GC05M148854
  • GC05M144021

Summaries for CSNK1A1 Gene

GeneCards Summary for CSNK1A1 Gene

CSNK1A1 (Casein Kinase 1 Alpha 1) is a Protein Coding gene. Among its related pathways are Wnt Signaling Pathways: beta-Catenin-dependent Wnt Signaling and mTOR signaling pathway (KEGG). GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CSNK1A1L.

UniProtKB/Swiss-Prot for CSNK1A1 Gene

  • Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at Ser-45. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis (PubMed:11955436, PubMed:1409656, PubMed:18305108). May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (PubMed:23902688).

Tocris Summary for CSNK1A1 Gene

  • Casein kinase I (CK1) is a monomeric serine-threonine protein kinase with 7 isoforms: alpha, beta, gamma1, gamma2, gamma3, delta and epsilon. CK1 is involved in many cellular processes including DNA repair, cell division, nuclear localization and membrane transport. Isoforms are also integral to development.

Gene Wiki entry for CSNK1A1 Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSNK1A1 Gene

Genomics for CSNK1A1 Gene

Regulatory Elements for CSNK1A1 Gene

Enhancers for CSNK1A1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F149463 1.3 Ensembl ENCODE 16.7 +86.0 86049 3.4 ATF1 PKNOX1 CREB3L1 ZNF2 ZNF121 GLIS2 GATA2 FOS ZNF263 YY2 CSNK1A1 ARHGEF37 MIR145 MIR143 RNU6-588P RPL29P14 CARMN IL17B LOC105378223 ENSG00000248647
GH05F149495 1.9 Ensembl ENCODE 11.1 +54.3 54276 4.1 ZNF362 ZNF664 ZNF316 POLR2A SCRT2 ZNF512 FOS MAFK EMSY PRDM1 ARHGEF37 MIR145 RPL29P14 CSNK1A1 MIR143 RNU6-588P CARMN IL17B PCYOX1L ENSG00000230551
GH05F149481 1.6 FANTOM5 Ensembl ENCODE 11.4 +65.0 64984 9.5 ATF1 PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF121 GATA2 ZNF416 ARHGEF37 HMGXB3 TIGD6 MIR145 RPL29P14 CSNK1A1 CARMN MIR143 IL17B RNU6-588P
GH05F149403 1.8 VISTA Ensembl ENCODE 10 +136.5 136504 23.4 ZFP64 ARID4B SIN3A YBX1 ZNF48 ZNF121 ZNF766 GLIS2 CBX5 ZNF143 LOC105378223 RNU6-588P ARHGEF37 CSNK1A1 RPL29P14 AFAP1L1 ENSG00000248647 ENSG00000253406 IL17B RPL7P1
GH05F149517 1.5 Ensembl 11 +33.8 33773 0.5 SCRT2 RAD21 MAFK RPL29P14 CSNK1A1 ARHGEF37 MIR143 CARMN IL17B ENSG00000230551 GC05M149546
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CSNK1A1 on UCSC Golden Path with GeneCards custom track

Promoters for CSNK1A1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001293595 852 3801 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1

Genomic Location for CSNK1A1 Gene

Chromosome:
5
Start:
149,492,197 bp from pter
End:
149,551,552 bp from pter
Size:
59,356 bases
Orientation:
Minus strand

Genomic View for CSNK1A1 Gene

Genes around CSNK1A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CSNK1A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CSNK1A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSNK1A1 Gene

Proteins for CSNK1A1 Gene

  • Protein details for CSNK1A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48729-KC1A_HUMAN
    Recommended name:
    Casein kinase I isoform alpha
    Protein Accession:
    P48729
    Secondary Accessions:
    • D3DQG0
    • D3DQG1
    • Q4JJA0
    • Q5U046
    • Q5U047
    • Q6FGA2
    • Q71TU5
    • Q96HD2
    • Q9UDK3

    Protein attributes for CSNK1A1 Gene

    Size:
    337 amino acids
    Molecular mass:
    38915 Da
    Quaternary structure:
    • Monomer. Interacts with the Axin complex. Interacts with TUT1, leading to TUT1 phosphorylation. Interacts with FAM83H; recruits CSNK1A1 to keratin filaments (PubMed:23902688).

    Three dimensional structures from OCA and Proteopedia for CSNK1A1 Gene

    Alternative splice isoforms for CSNK1A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CSNK1A1 Gene

Selected DME Specific Peptides for CSNK1A1 Gene

P48729:
  • QGGVGIP
  • ESKLYKI
  • HRDIKPDN
  • KYEKISEKK
  • ESLGYVL
  • DWTMLKQK
  • RKIGSGSFG
  • WYGQEKD
  • LTGTARY
  • LPWQGLKA
  • HPQLLYESKLY
  • RDIKPDNFL
  • PDNFLMG
  • LADQMISRI
  • GQQAQTPTG
  • YLRQLFR
  • LLGPSLEDLF
  • MYFNRTSLPWQGL
  • DFGLAKKYRD
  • GIEQSRRDD
  • VAVKLESQK

Post-translational modifications for CSNK1A1 Gene

  • Ubiquitination at Lys 8, Lys 62, Lys 65, Lys 138, Lys 225, and Lys 304
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for CSNK1A1 (Casein Kinase 1 alpha)
  • Cell Signaling Technology (CST) Antibodies for CSNK1A1 (CK1A)
  • Cloud-Clone Corp. Antibodies for CSNK1A1

Domains & Families for CSNK1A1 Gene

Gene Families for CSNK1A1 Gene

Protein Domains for CSNK1A1 Gene

Graphical View of Domain Structure for InterPro Entry

P48729

UniProtKB/Swiss-Prot:

KC1A_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
genes like me logo Genes that share domains with CSNK1A1: view

Function for CSNK1A1 Gene

Molecular function for CSNK1A1 Gene

GENATLAS Biochemistry:
casein kinase I,catalytic unit,alpha 1,involved in the transduction of WNT signal
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at Ser-45. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis (PubMed:11955436, PubMed:1409656, PubMed:18305108). May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (PubMed:23902688).

Enzyme Numbers (IUBMB) for CSNK1A1 Gene

Gene Ontology (GO) - Molecular Function for CSNK1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity TAS 10777483
GO:0004674 protein serine/threonine kinase activity TAS --
GO:0005515 protein binding IPI 16511560
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA,TAS --
genes like me logo Genes that share ontologies with CSNK1A1: view
genes like me logo Genes that share phenotypes with CSNK1A1: view

Animal Models for CSNK1A1 Gene

MGI Knock Outs for CSNK1A1:

Animal Model Products

  • Taconic Biosciences Mouse Models for CSNK1A1

miRNA for CSNK1A1 Gene

miRTarBase miRNAs that target CSNK1A1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CSNK1A1 Gene

Localization for CSNK1A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSNK1A1 Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Nucleus speckle. Note=Localizes to the centrosome in interphase cells, and to kinetochore fibers during mitosis. Also recruited to the keratin cytoskeleton (PubMed:23902688). {ECO:0000269 PubMed:1409656, ECO:0000269 PubMed:23902688}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CSNK1A1 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CSNK1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IEA --
GO:0000776 kinetochore IEA --
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005634 nucleus IEA --
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with CSNK1A1: view

Pathways & Interactions for CSNK1A1 Gene

SuperPathways for CSNK1A1 Gene

SuperPathway Contained pathways
1 T41 mutants of beta-catenin arent phosphorylated
2 Regulation of activated PAK-2p34 by proteasome mediated degradation
3 Signaling by Hedgehog
4 Hedgehog Pathway
5 Wnt Signaling Pathways: beta-Catenin-dependent Wnt Signaling
genes like me logo Genes that share pathways with CSNK1A1: view

SIGNOR curated interactions for CSNK1A1 Gene

Gene Ontology (GO) - Biological Process for CSNK1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000902 cell morphogenesis IEA --
GO:0006468 protein phosphorylation IDA 18305108
GO:0006909 phagocytosis IBA --
GO:0007030 Golgi organization IMP 25500533
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with CSNK1A1: view

Drugs & Compounds for CSNK1A1 Gene

(11) Drugs for CSNK1A1 Gene - From: ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
IC261 Experimental Pharma 0
CKI 7 dihydrochloride Pharma CK1 inhibitor 0
PF-670462 Pharma CK1 ε/δ inhibitor, Potent and selective CK1eta and CK1delta inhibitor 0
CASEIN KINASE I INHIBITOR Pharma 0

(2) Additional Compounds for CSNK1A1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0

(5) Tocris Compounds for CSNK1A1 Gene

Compound Action Cas Number
CKI 7 dihydrochloride CK1 inhibitor 1177141-67-1
D 4476 Selective CK1 inhibitor. Also inhibits TGF-betaRI 301836-43-1
LH 846 Selective casein kinase 1delta inhibitor 639052-78-1
PF 4800567 hydrochloride Selective casein kinase 1eta inhibitor 1391052-28-0
PF 670462 Potent and selective CK1eta and CK1delta inhibitor 950912-80-8

(2) ApexBio Compounds for CSNK1A1 Gene

Compound Action Cas Number
CKI 7 dihydrochloride 1177141-67-1
PF-670462 CK1 ε/δ inhibitor 950912-80-8
genes like me logo Genes that share compounds with CSNK1A1: view

Transcripts for CSNK1A1 Gene

Unigene Clusters for CSNK1A1 Gene

Casein kinase 1, alpha 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CSNK1A1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1: - - - - - - -
SP2: - - - -
SP3: - -
SP4: - - -
SP5: - - -
SP6: - - -
SP7: - -
SP8:

Relevant External Links for CSNK1A1 Gene

GeneLoc Exon Structure for
CSNK1A1
ECgene alternative splicing isoforms for
CSNK1A1

Expression for CSNK1A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CSNK1A1 Gene

Protein differential expression in normal tissues from HIPED for CSNK1A1 Gene

This gene is overexpressed in Cervix (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CSNK1A1 Gene



Protein tissue co-expression partners for CSNK1A1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CSNK1A1 Gene:

CSNK1A1

SOURCE GeneReport for Unigene cluster for CSNK1A1 Gene:

Hs.529862
genes like me logo Genes that share expression patterns with CSNK1A1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CSNK1A1 Gene

Orthologs for CSNK1A1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CSNK1A1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia -- 35
  • 100 (a)
ManyToMany
CSNK1A1 34
  • 98.08 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 100 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia CSNK1A1 34 35
  • 99.91 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 99 (a)
ManyToMany
-- 35
  • 79 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia CSNK1A1 34
  • 96.4 (n)
-- 35
  • 83 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Csnk1a1 34
  • 94.96 (n)
mouse
(Mus musculus)
Mammalia Csnk1a1 34 16 35
  • 94.65 (n)
chicken
(Gallus gallus)
Aves CSNK1A1 34 35
  • 90.5 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 100 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia csnk1a1 34
  • 84.77 (n)
Str.3026 34
African clawed frog
(Xenopus laevis)
Amphibia MGC68433 34
zebrafish
(Danio rerio)
Actinopterygii csnk1a1 34 35 35
  • 99 (a)
LOC100334765 34
  • 83.56 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.744 34
fruit fly
(Drosophila melanogaster)
Insecta dco 36
  • 70 (a)
CkIalpha 36 34 35
  • 67.81 (n)
CG7094 36
  • 64 (a)
CG2577 36
  • 58 (a)
CG12147 36
  • 55 (a)
CG9962 36
  • 49 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000627 34
  • 67.49 (n)
worm
(Caenorhabditis elegans)
Secernentea kin-19 35
  • 82 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons ckl8 34
  • 61.43 (n)
rice
(Oryza sativa)
Liliopsida Os04g0514800 34
  • 66.44 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 92 (a)
ManyToMany
CS-CKI 35
  • 88 (a)
ManyToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes hhp2 34
  • 61.55 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.22 34
Species where no ortholog for CSNK1A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CSNK1A1 Gene

ENSEMBL:
Gene Tree for CSNK1A1 (if available)
TreeFam:
Gene Tree for CSNK1A1 (if available)

Paralogs for CSNK1A1 Gene

Variants for CSNK1A1 Gene

Sequence variations from dbSNP and Humsavar for CSNK1A1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
VAR_042073 A breast pleomorphic lobular carcinoma sample
rs10036211 -- 149,500,702(+) gatta(C/T)aggag intron-variant
rs10036462 -- 149,495,814(+) TTTTT(G/T)CATTT downstream-variant-500B
rs10037311 -- 149,536,096(+) TCACA(A/G)GCACG intron-variant
rs10058728 -- 149,524,529(+) ACATC(A/T)CCAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CSNK1A1 Gene

Variant ID Type Subtype PubMed ID
nsv980743 CNV duplication 23825009
nsv968261 CNV duplication 23825009
nsv518039 CNV gain 19592680
nsv516848 CNV gain 19592680
nsv5059 CNV insertion 18451855
esv2730908 CNV deletion 23290073
esv2585670 CNV insertion 19546169
esv24490 CNV gain 19812545

Variation tolerance for CSNK1A1 Gene

Residual Variation Intolerance Score: 33.5% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CSNK1A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CSNK1A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSNK1A1 Gene

Disorders for CSNK1A1 Gene

Relevant External Links for CSNK1A1

Genetic Association Database (GAD)
CSNK1A1
Human Genome Epidemiology (HuGE) Navigator
CSNK1A1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CSNK1A1

No disorders were found for CSNK1A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CSNK1A1 Gene

Publications for CSNK1A1 Gene

  1. Cloning and chromosomal localization of the gene coding for human protein kinase CK1. (PMID: 8050587) Tapia C. … Allende J.E. (FEBS Lett. 1994) 2 3 4 64
  2. A novel mechanism of keratin cytoskeleton organization through casein kinase II+ and FAM83H in colorectal cancer. (PMID: 23902688) Kuga T. … Tomonaga T. (J. Cell. Sci. 2013) 3 4 64
  3. Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations. (PMID: 21642993) Wu C. … Lin D. (Nat. Genet. 2011) 3 46 64
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  5. Mammalian casein kinase 1alpha and its leishmanial ortholog regulate stability of IFNAR1 and type I interferon signaling. (PMID: 19805514) Liu J. … Fuchs S.Y. (Mol. Cell. Biol. 2009) 3 22 64

Products for CSNK1A1 Gene

Sources for CSNK1A1 Gene

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