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Aliases for CSN3 Gene

Aliases for CSN3 Gene

  • Casein Kappa 2 3
  • CSN10 3 4
  • CSNK 3 4
  • Casein, Kappa 2
  • Kappa-Casein 3
  • CSN10, 6
  • CASK 4
  • KCA 3

External Ids for CSN3 Gene

Previous HGNC Symbols for CSN3 Gene

  • CSN10

Previous GeneCards Identifiers for CSN3 Gene

  • GC04P071156
  • GC04P071358
  • GC04P071423
  • GC04P071289
  • GC04P066910

Summaries for CSN3 Gene

GeneCards Summary for CSN3 Gene

CSN3 (Casein Kappa) is a Protein Coding gene. Diseases associated with CSN3 include dentin sensitivity and mammary paget's disease. Among its related pathways are Degradation of the extracellular matrix and Non-integrin membrane-ECM interactions.

UniProtKB/Swiss-Prot for CSN3 Gene

  • Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk

Gene Wiki entry for CSN3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSN3 Gene

Genomics for CSN3 Gene

Regulatory Elements for CSN3 Gene

Genomic Location for CSN3 Gene

Start:
70,242,588 bp from pter
End:
70,251,428 bp from pter
Size:
8,841 bases
Orientation:
Plus strand

Genomic View for CSN3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CSN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSN3 Gene

Proteins for CSN3 Gene

  • Protein details for CSN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07498-CASK_HUMAN
    Recommended name:
    Kappa-casein
    Protein Accession:
    P07498
    Secondary Accessions:
    • Q13575

    Protein attributes for CSN3 Gene

    Size:
    182 amino acids
    Molecular mass:
    20305 Da
    Quaternary structure:
    • Heteromultimers composed of alpha-s1 casein and kappa casein linked by disulfide bonds

neXtProt entry for CSN3 Gene

Proteomics data for CSN3 Gene at MOPED

Post-translational modifications for CSN3 Gene

  • The N-terminus is blocked
  • Glycosylation at Thr133, Thr143, Thr148, Thr151, Thr157, Thr167, and Thr169
  • Modification sites at PhosphoSitePlus

Other Protein References for CSN3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CSN3 Gene

Domains for CSN3 Gene

Protein Domains for CSN3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CSN3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P07498

UniProtKB/Swiss-Prot:

CASK_HUMAN :
  • P07498
Family:
  • Belongs to the kappa-casein family.
genes like me logo Genes that share domains with CSN3: view

No data available for Gene Families for CSN3 Gene

Function for CSN3 Gene

Molecular function for CSN3 Gene

UniProtKB/Swiss-Prot Function:
Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk

Gene Ontology (GO) - Molecular Function for CSN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CSN3: view

Phenotypes for CSN3 Gene

genes like me logo Genes that share phenotypes with CSN3: view

Animal Models for CSN3 Gene

MGI Knock Outs for CSN3:

miRNA for CSN3 Gene

miRTarBase miRNAs that target CSN3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CSN3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CSN3 Gene

Localization for CSN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSN3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CSN3 Gene COMPARTMENTS Subcellular localization image for CSN3 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 2
plasma membrane 2
cytoskeleton 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CSN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 16502470
genes like me logo Genes that share ontologies with CSN3: view

Pathways for CSN3 Gene

genes like me logo Genes that share pathways with CSN3: view

Pathways by source for CSN3 Gene

Gene Ontology (GO) - Biological Process for CSN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007595 lactation IDA 7979373
GO:0050821 protein stabilization IDA 7979373
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with CSN3: view

Compounds for CSN3 Gene

(19) Novoseek inferred chemical compound relationships for CSN3 Gene

Compound -log(P) Hits PubMed IDs
rennet 90.1 6
whey 83.3 27
glucono-delta-lactone 79.6 1
sodium caseinate 71.9 3
allergens 47.1 3
genes like me logo Genes that share compounds with CSN3: view

Transcripts for CSN3 Gene

mRNA/cDNA for CSN3 Gene

(4) REFSEQ mRNAs :
(12) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CSN3 Gene

Casein kappa:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CSN3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CSN3 Gene

No ASD Table

Relevant External Links for CSN3 Gene

GeneLoc Exon Structure for
CSN3
ECgene alternative splicing isoforms for
CSN3

Expression for CSN3 Gene

mRNA expression in normal human tissues for CSN3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CSN3 Gene

This gene is overexpressed in Breast - Mammary Tissue (33.3) and Minor Salivary Gland (19.4).

Protein differential expression in normal tissues for CSN3 Gene

This gene is overexpressed in Milk (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CSN3 Gene

SOURCE GeneReport for Unigene cluster for CSN3 Gene Hs.54415

mRNA Expression by UniProt/SwissProt for CSN3 Gene

P07498-CASK_HUMAN
Tissue specificity: Mammary gland specific. Secreted in milk
genes like me logo Genes that share expressions with CSN3: view

Expression partners for CSN3 Gene

In Situ Assay Products

Orthologs for CSN3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CSN3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CSN3 35
  • 73.82 (n)
  • 55.93 (a)
CSN3 36
  • 52 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CSN3 35
  • 80.16 (n)
  • 65.64 (a)
CSN3 36
  • 64 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Csn3 35
  • 61.51 (n)
  • 37.5 (a)
Csn3 16
Csn3 36
  • 37 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CSN3 35
  • 99.27 (n)
  • 98.35 (a)
CSN3 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Csn3 35
  • 62.25 (n)
  • 39.16 (a)
Species with no ortholog for CSN3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CSN3 Gene

ENSEMBL:
Gene Tree for CSN3 (if available)
TreeFam:
Gene Tree for CSN3 (if available)

Paralogs for CSN3 Gene

No data available for Paralogs for CSN3 Gene

Variants for CSN3 Gene

Sequence variations from dbSNP and Humsavar for CSN3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs777798 -- 70,243,445(-) CCATT(C/T)GATGG intron-variant
rs777799 -- 70,243,186(-) TTGCG(C/T)ATCAG intron-variant
rs777800 -- 70,242,976(-) CCTGT(A/G)GAGTT intron-variant
rs1048152 - 70,249,239(+) ACGTC(G/T)CCCAA reference, missense
rs1399253 -- 70,251,485(-) ATAGC(A/G)TTTCA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for CSN3 Gene

Variant ID Type Subtype PubMed ID
nsv829963 CNV Gain 17160897
nsv879466 CNV Loss 21882294
nsv822612 CNV Loss 20364138

Relevant External Links for CSN3 Gene

HapMap Linkage Disequilibrium report
CSN3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSN3 Gene

Disorders for CSN3 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for CSN3 Gene in MalaCards »

(2) Diseases for CSN3 Gene including...

(2) University of Copenhagen DISEASES for CSN3 Gene

(8) Novoseek inferred disease relationships for CSN3 Gene

Disease -log(P) Hits PubMed IDs
allergy milk 82.8 1
allergy food 39 1
allergy 27.4 2
dermatitis atopic 17 3
tumors 0.6 1

Relevant External Links for CSN3

Genetic Association Database (GAD)
CSN3
Human Genome Epidemiology (HuGE) Navigator
CSN3
genes like me logo Genes that share disorders with CSN3: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for CSN3 Gene

Publications for CSN3 Gene

  1. Cloning and sequencing of human kappa-casein cDNA. (PMID: 1296818) Bergstroem S. … Stroemqvist M. (DNA Seq. 1992) 3 4 23
  2. Structural features of a peptide corresponding to human kappa-casein residues 84-101 by 1H-nuclear magnetic resonance spectroscopy. (PMID: 10191473) Plowman J.E. … Cross J.J. (J. Dairy Res. 1999) 3 4 23
  3. Structure of the human kappa-casein gene. (PMID: 8863730) Edlund A. … Hansson L. (Gene 1996) 2 3 4
  4. Genomic organization and chromosomal localization of the human casein gene family. (PMID: 9050925) Fujiwara Y. … Ueda M. (Hum. Genet. 1997) 2 3
  5. Preparation and amino acid sequence of human kappa-casein. (PMID: 4018271) Brignon G. … Ribadeau-Dumas B. (FEBS Lett. 1985) 3 4

Products for CSN3 Gene

Sources for CSN3 Gene

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