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Aliases for CSN3 Gene

Aliases for CSN3 Gene

  • Casein Kappa 2 3
  • CSN10 3 4
  • CSNK 3 4
  • Casein, Kappa 2
  • CNS10 3
  • CASK 4
  • KCA 3

External Ids for CSN3 Gene

Previous HGNC Symbols for CSN3 Gene

  • CSN10

Previous GeneCards Identifiers for CSN3 Gene

  • GC04P071156
  • GC04P071358
  • GC04P071423
  • GC04P071289
  • GC04P066910

Summaries for CSN3 Gene

GeneCards Summary for CSN3 Gene

CSN3 (Casein Kappa) is a Protein Coding gene. Diseases associated with CSN3 include dentin sensitivity and mastitis. Among its related pathways are Degradation of the extracellular matrix and Non-integrin membrane-ECM interactions.

UniProtKB/Swiss-Prot for CSN3 Gene

  • Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk

Gene Wiki entry for CSN3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSN3 Gene

Genomics for CSN3 Gene

Regulatory Elements for CSN3 Gene

Genomic Location for CSN3 Gene

Chromosome:
4
Start:
70,238,306 bp from pter
End:
70,251,432 bp from pter
Size:
13,127 bases
Orientation:
Plus strand

Genomic View for CSN3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CSN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSN3 Gene

Proteins for CSN3 Gene

  • Protein details for CSN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07498-CASK_HUMAN
    Recommended name:
    Kappa-casein
    Protein Accession:
    P07498
    Secondary Accessions:
    • Q13575

    Protein attributes for CSN3 Gene

    Size:
    182 amino acids
    Molecular mass:
    20305 Da
    Quaternary structure:
    • Heteromultimers composed of alpha-s1 casein and kappa casein linked by disulfide bonds

neXtProt entry for CSN3 Gene

Proteomics data for CSN3 Gene at MOPED

Post-translational modifications for CSN3 Gene

  • The N-terminus is blocked
  • Glycosylation at Thr 133, Thr 143, Thr 148, Thr 151, Thr 157, Thr 167, Thr 169, and Thr 178
  • Modification sites at PhosphoSitePlus

Other Protein References for CSN3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CSN3 Gene

Domains & Families for CSN3 Gene

Protein Domains for CSN3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CSN3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P07498

UniProtKB/Swiss-Prot:

CASK_HUMAN :
  • Belongs to the kappa-casein family.
Family:
  • Belongs to the kappa-casein family.
genes like me logo Genes that share domains with CSN3: view

No data available for Gene Families for CSN3 Gene

Function for CSN3 Gene

Molecular function for CSN3 Gene

UniProtKB/Swiss-Prot Function:
Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk

Gene Ontology (GO) - Molecular Function for CSN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CSN3: view
genes like me logo Genes that share phenotypes with CSN3: view

Animal Models for CSN3 Gene

MGI Knock Outs for CSN3:

miRNA for CSN3 Gene

miRTarBase miRNAs that target CSN3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CSN3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CSN3 Gene

Localization for CSN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSN3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CSN3 Gene COMPARTMENTS Subcellular localization image for CSN3 gene
Compartment Confidence
extracellular 5
cytosol 2
endoplasmic reticulum 2
plasma membrane 2
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CSN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 7979373
genes like me logo Genes that share ontologies with CSN3: view

Pathways & Interactions for CSN3 Gene

genes like me logo Genes that share pathways with CSN3: view

Pathways by source for CSN3 Gene

Gene Ontology (GO) - Biological Process for CSN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007595 lactation IDA 7979373
GO:0050821 protein stabilization IDA 7979373
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with CSN3: view

No data available for SIGNOR curated interactions for CSN3 Gene

Drugs & Compounds for CSN3 Gene

(5) Drugs for CSN3 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ethanol Approved Pharma 1708
Iron Approved Pharma 957
lactose Experimental Pharma 0
Urea Experimental Pharma 0
Calcium Nutra 0

(14) Additional Compounds for CSN3 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Allergens
FIBRINOGEN
glucono-delta-lactone
glucose
hydrogen
  • Dihydrogen
  • Hydrogen gas
1333-74-0
genes like me logo Genes that share compounds with CSN3: view

Transcripts for CSN3 Gene

mRNA/cDNA for CSN3 Gene

(4) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CSN3 Gene

Casein kappa:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CSN3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CSN3 Gene

No ASD Table

Relevant External Links for CSN3 Gene

GeneLoc Exon Structure for
CSN3
ECgene alternative splicing isoforms for
CSN3

Expression for CSN3 Gene

mRNA expression in normal human tissues for CSN3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CSN3 Gene

This gene is overexpressed in Breast - Mammary Tissue (x33.3) and Minor Salivary Gland (x19.4).

Protein differential expression in normal tissues from HIPED for CSN3 Gene

This gene is overexpressed in Milk (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CSN3 Gene



SOURCE GeneReport for Unigene cluster for CSN3 Gene Hs.54415

mRNA Expression by UniProt/SwissProt for CSN3 Gene

P07498-CASK_HUMAN
Tissue specificity: Mammary gland specific. Secreted in milk
genes like me logo Genes that share expression patterns with CSN3: view

Protein tissue co-expression partners for CSN3 Gene

Primer Products

In Situ Assay Products

Orthologs for CSN3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CSN3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CSN3 35
  • 73.82 (n)
  • 55.93 (a)
CSN3 36
  • 52 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CSN3 35
  • 80.16 (n)
  • 65.64 (a)
CSN3 36
  • 64 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Csn3 35
  • 61.51 (n)
  • 37.5 (a)
Csn3 16
Csn3 36
  • 37 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CSN3 35
  • 99.27 (n)
  • 98.35 (a)
CSN3 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Csn3 35
  • 62.25 (n)
  • 39.16 (a)
Species with no ortholog for CSN3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CSN3 Gene

ENSEMBL:
Gene Tree for CSN3 (if available)
TreeFam:
Gene Tree for CSN3 (if available)

Paralogs for CSN3 Gene

No data available for Paralogs for CSN3 Gene

Variants for CSN3 Gene

Sequence variations from dbSNP and Humsavar for CSN3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
VAR_026338 -
VAR_026339 -
VAR_026340 -

Structural Variations from Database of Genomic Variants (DGV) for CSN3 Gene

Variant ID Type Subtype PubMed ID
nsv829963 CNV Gain 17160897
nsv879466 CNV Loss 21882294
nsv822612 CNV Loss 20364138

Variation tolerance for CSN3 Gene

Residual Variation Intolerance Score: 81.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.58; 44.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CSN3 Gene

HapMap Linkage Disequilibrium report
CSN3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSN3 Gene

Disorders for CSN3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CSN3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
dentin sensitivity
  • sensitive dentin
mastitis
  • inflammatory breast disease
- elite association
Search CSN3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CSN3

Genetic Association Database (GAD)
CSN3
Human Genome Epidemiology (HuGE) Navigator
CSN3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CSN3
genes like me logo Genes that share disorders with CSN3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CSN3 Gene

Publications for CSN3 Gene

  1. Short communication: separation and quantification of caseins and casein macropeptide using ion-exchange chromatography. (PMID: 20172209) Holland B. … Corredig M. (J. Dairy Sci. 2010) 23 67
  2. Casein retention in curd and loss of casein into whey at chymosin-induced coagulation of milk. (PMID: 19939322) HallAcn E. … AndrAcn A. (J. Dairy Res. 2010) 23 67
  3. The impact of the concentration of casein micelles and whey protein-stabilized fat globules on the rennet-induced gelation of milk. (PMID: 19022631) Gaygadzhiev Z. … Alexander M. (Colloids Surf B Biointerfaces 2009) 23 67
  4. (-)-epigallocatechin-3-gallate (EGCG) maintains kappa-casein in its pre-fibrillar state without redirecting its aggregation pathway. (PMID: 19616561) Hudson S.A. … Carver J.A. (J. Mol. Biol. 2009) 23 67
  5. Comparison of the orogenic displacement of sodium caseinate with the caseins from the air-water interface by nonionic surfactants. (PMID: 19505156) Woodward N.C. … Morris V.J. (Langmuir 2009) 23 67

Products for CSN3 Gene

Sources for CSN3 Gene

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