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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CSN2 Gene

protein-coding   GIFtS: 60
GCID: GC04M070869

Casein Beta


(Previous symbol: CASB)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Casein Beta1 2
CASB1 2 3
beta-casein2

External Ids:    HGNC: 24471   Entrez Gene: 14472   Ensembl: ENSG000001352227   OMIM: 1154605   UniProtKB: P058143   

Export aliases for CSN2 gene to outside databases

Previous GC identifers: GC04M070731 GC04M071070 GC04M071136 GC04M071001 GC04M066618


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CSN2 Gene: 
CSN2 (casein beta) is a protein-coding gene. Diseases associated with CSN2 include visceral leishmaniasis, and tetanus, and among its related super-pathways are Prolactin Signaling Pathway and PIP3 activates AKT signaling. GO annotations related to this gene include enzyme inhibitor activity and calcium ion binding.

UniProtKB/Swiss-Prot: CASB_HUMAN, P05814
Function: Important role in determination of the surface properties of the casein micelles

Gene Wiki entry for CSN2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_022778.16  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CSN2 gene promoter:
         STAT5B   TBP   p53   AML1a   Evi-1   MEF-2A   POU2F1   POU2F1a   aMEF-2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCSN2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CSN2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CSN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21.1   Ensembl cytogenetic band:  4q13.3   HGNC cytogenetic band: 4q21.1

CSN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CSN2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M070869:  view genomic region     (about GC identifiers)

Start:
70,820,974 bp from pter      End:
70,826,726 bp from pter
Size:
5,753 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CASB_HUMAN, P05814 (See protein sequence)
Recommended Name: Beta-casein precursor  
Size: 226 amino acids; 25382 Da
Subcellular location: Secreted
Secondary accessions: Q4VAZ9 Q9UCM5

Explore the universe of human proteins at neXtProt for CSN2: NX_P05814

Explore proteomics data for CSN2 at MOPED 

Post-translational modifications:

  • UniProtKB: Form 1-P is phosphorylated once; half of the molecules are phosphorylated on Ser-24, half on Ser-25
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P05814

  • CSN2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CSN2 Protein Expression
    REFSEQ proteins: NP_001882.1  
    ENSEMBL proteins: 
     ENSP00000341030  
    Reactome Protein details: P05814
    Human Recombinant Protein Products for CSN2: 
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    Novus Biologicals CSN2 Proteins
    Novus Biologicals CSN2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for CSN2
    Cloud-Clone Corp. Proteins for CSN2 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--

    CSN2 for ontologies           About GeneDecksing



    CSN2 Antibody Products: 
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    Cloud-Clone Corp. ELISAs for CSN2 
    Cloud-Clone Corp. CLIAs for CSN2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR001588 Casein
     IPR016345 Casein_beta

    Graphical View of Domain Structure for InterPro Entry P05814

    ProtoNet protein and cluster: P05814

    1 Blocks protein domain: IPB001588 Casein

    UniProtKB/Swiss-Prot: CASB_HUMAN, P05814
    Similarity: Belongs to the beta-casein family


    CSN2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CASB_HUMAN, P05814
    Function: Important role in determination of the surface properties of the casein micelles

         Genatlas biochemistry entry for CSN2:
    casein,beta

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004857enzyme inhibitor activity TAS2387396
    GO:0005215transporter activity IEA--
    GO:0005509calcium ion binding TAS2387396
         
    CSN2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CSN2:
     Increased cell death in breast 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Csn2):
     endocrine/exocrine gland  integument  other 

    CSN2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Csn2tm1Psim for CSN2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CSN2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CSN2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CSN2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CSN2 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CSN2
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate CSN2:
    hsa-miR-203 hsa-miR-3671 hsa-miR-4264 hsa-miR-183* hsa-miR-145
    SwitchGear 3'UTR luciferase reporter plasmidCSN2 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    In Situ Assay
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CSN2 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Development Prolactin receptor signaling
    Development Prolactin receptor signaling0.39
    Prolactin signaling pathway0.33
    2PIP3 activates AKT signaling
    Signaling by ERBB40.67
    3Signaling by GPCR
    Signal Transduction0.55
    4ErbB4 Pathway
    Prolactin Signaling0.54
    5Prolactin receptor signaling
    Nuclear signaling by ERBB40.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for CSN2
        Development Prolactin receptor signaling

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for CSN2
        Prolactin Signaling

    1 GeneGo (Thomson Reuters) Pathway for CSN2
        Development Prolactin receptor signaling

    2 BioSystems Pathways for CSN2
        Signaling events mediated by PTP1B
    Glucocorticoid receptor regulatory network


    3        Reactome Pathways for CSN2
        Signal Transduction
    Signaling by ERBB4
    Nuclear signaling by ERBB4


    1         Kegg Pathway  (Kegg details for CSN2):
        Prolactin signaling pathway


    CSN2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CSN2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    5/26 Interacting proteins for CSN2 (P058142, 3 ENSP000003410304) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NFYCQ139523, ENSP000003966204I2D: score=3 STRING: ENSP00000396620
    CSN3P074983, ENSP000003048224I2D: score=1 STRING: ENSP00000304822
    HTRA2O434643, ENSP000002580804I2D: score=1 STRING: ENSP00000258080
    NEK3P519563, ENSP000003832104I2D: score=1 STRING: ENSP00000383210
    NEK8Q86SG63, ENSP000002687664I2D: score=1 STRING: ENSP00000268766
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----
    GO:0006816calcium ion transport TAS2387396
    GO:0043086negative regulation of catalytic activity TAS2387396

    CSN2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CSN2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CSN2 (CASB)

    10/55 Novoseek inferred chemical compound relationships for CSN2 gene (see all 55)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    whey 75.4 26 15930449 (5), 16848557 (2), 11174844 (1), 14976147 (1) (see all 18)
    imac 68.8 8 15565681 (1), 17723369 (1), 10960913 (1), 17900103 (1)
    exorphins 66.1 1 1764604 (1)
    sodium caseinate 65.7 8 19505156 (2), 15542336 (1), 16080171 (1)
    glyceryl monooleate 59.7 9 16618167 (3), 15248719 (2), 17580860 (2), 12502394 (1)
    rennet 59.5 2 10905693 (1)
    monoacylglycerol 57.2 27 16471923 (5), 15248719 (4), 19127751 (4), 16618167 (3) (see all 7)
    phosphothreonine 56.7 2 11857762 (1)
    phosphoserine 56.3 4 19641788 (1), 11857762 (1), 18420601 (1)
    zirconia 43 1 17269746 (1)

    Search CenterWatch for drugs/clinical trials and news about CSN2 / CASB

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CSN2 gene: 
    NM_001891.2  

    Unigene Cluster for CSN2:

    Casein beta
    Hs.2242  [show with all ESTs]
    Unigene Representative Sequence: NM_001891
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000353151(uc003hes.4 uc003het.4)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate CSN2:
    hsa-miR-203 hsa-miR-3671 hsa-miR-4264 hsa-miR-183* hsa-miR-145
    SwitchGear 3'UTR luciferase reporter plasmidCSN2 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    BC069554.1 BC096194.3 BC096195.1 BC096196.3 BC096197.3 X13766.1 X17070.1 X55739.1 

    1 DOTS entry:

    DT.407783 

    8 AceView cDNA sequences:

    BG184927 BC069554 X13766 BG208669 BG219803 X17070 NM_001891 X55739 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CSN2 expression in normal human tissues (normalized intensities)      CSN2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CSN2 Expression
    About this image


    CSN2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Breast (Uncategorized)
             mammary gland   
     
     Neural Tube (Nervous System)
             Prosencephalon
     
     Pancreas (Endocrine System)

    See CSN2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CSN2

    SOURCE GeneReport for Unigene cluster: Hs.2242

    UniProtKB/Swiss-Prot: CASB_HUMAN, P05814
    Tissue specificity: Mammary gland specific. Secreted in milk

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for CSN2 gene from 1/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Csn21 , 5 casein beta1, 5 66.67(n)1
    48.84(a)1
      5 (43.56 cM)5
    129911  NM_009972.11  NP_034102.11 
     876926245 


    ENSEMBL Gene Tree for CSN2 (if available)
    TreeFam Gene Tree for CSN2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/201 SNPs in CSN2 are shown (see all 201)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1164622171,2
    C,F--70820792(+) CTATAG/ACAAAT 1 -- int11Minor allele frequency- A:0.03WA 118
    rs14914291,2
    C,F,O,H--70820800(+) AATGGG/AGTATA 1 -- int120Minor allele frequency- A:0.07NS EA NA WA CSA 932
    rs14914301,2
    C,F--70820814(+) GCATCC/TTTTCT 1 -- int15Minor allele frequency- T:0.04EA NA 158
    rs171478851,2
    C,F,H--70820946(+) ATTAGG/ATTTGA 1 -- int115Minor allele frequency- A:0.04NA NS EA WA 1628
    rs1862696221,2
    --70820947(+) TTAGGC/TTTGAA 1 -- int10--------
    rs26378161,2
    C,F--70821025(+) CTTAAA/GGAAAT 1 -- ut312Minor allele frequency- G:0.17NA EA 240
    rs1152928301,2
    C,F--70821064(+) TGTATA/GCATAT 1 -- ut311Minor allele frequency- G:0.02WA 118
    rs1474119871,2
    C--70821195(+) ATATA-/AAAT  
            
    AAATA
    1 -- ut310--------
    rs1473022441,2
    --70821207(+) TAAAGA/GGACAA 1 -- ut310--------
    rs1159398621,2
    C,F--70821232(+) ATATAA/CACTCA 1 -- ut311Minor allele frequency- C:0.04WA 118

    HapMap Linkage Disequilibrium report for CSN2 (70820974 - 70826726 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CSN2:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv5629n71CNV Loss21882294
    dgv5628n71CNV Loss21882294
    nsv879455CNV Loss21882294
    nsv879460CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 115460    OMIM disorders: --

    20 diseases for CSN2:    About MalaCards
    visceral leishmaniasis    tetanus    acquired immunodeficiency syndrome    type 1 diabetes mellitus
    mastitis    type 1 diabetes    leishmaniasis    acute leukemia
    influenza    autoimmune thyroiditis    duodenitis    thyroid cancer
    diabetes mellitus    cytochrome p450    thyroiditis    breast cancer
    colon cancer    myeloid leukemia    leukemia    pancreatitis

    1 disease from the University of Copenhagen DISEASES database for CSN2:
    Breast cancer

    CSN2 for disorders           About GeneDecksing

    10/18 Novoseek inferred disease relationships for CSN2 gene (see all 18)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    allergy milk 59.9 2 11678861 (2)
    autoimmune thyroid disease 17.2 3 8843812 (2), 12198602 (1)
    diabetes mellitus insulin-dependent 7.32 6 11015514 (2), 9662058 (2), 9230603 (1), 11850100 (1)
    breast cancer 5.98 4 15534001 (2), 9813040 (1), 18843297 (1)
    diabetes autoimmune 4.16 2 12198602 (2)
    carcinoma 4.13 1 9092813 (1)
    tumors 2.69 5 14976147 (1), 8440707 (1), 9537254 (1), 9374476 (1) (see all 5)
    immunodeficiency 2.47 1 16545061 (1)
    aids 1.82 2 11185556 (1), 16545061 (1)
    autoimmune diseases 0 1 12198602 (1)


    Export disorders for CSN2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CSN2 gene, integrated from 9 sources (see all 362):
    (articles sorted by number of sources associating them with CSN2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Regional localization of human beta-casein gene (CSN2) to 4pter-q21. (PubMed id 1577486)1, 3, 9 Menon R.S....Ham R.G. (1992)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Structure of the human beta-casein encoding gene. (PubMed id 8112603)1, 2 Hansson L.... Bergstroem S. (1994)
    4. Cloning and sequencing of a cDNA encoding human milk beta-casein. (PubMed id 2387396)1, 2 Loennerdal B.... Hernell O. (1990)
    5. Human beta-casein: partial cDNA sequence and apparent polymorphism. (PubMed id 2717418)1, 2 Menon R.S. and Ham R.G. (1989)
    6. Human beta-casein. Amino acid sequence and identification of phosphorylation sites. (PubMed id 6715339)1, 2 Greenberg R.... Dower H.J. (1984)
    7. New functions of lactoferrin and beta-casein in mammalian milk as cysteine protease inhibitors. (PubMed id 12788072)1, 9 Ohashi A....Katunuma N. (2003)
    8. Assignment of the gene for beta-casein (CSN2) to 4q13 --> q21 in humans and 3p13 --> p12 in chimpanzees. (PubMed id 8565637)1, 9 McConkey E.H....Sutherland G.R. (1996)
    9. Derivatives of human beta-casein fragments (54-59) ex hibit highly potent immunosuppressant activity. (PubMed id 19463972)1, 9 Puri A....Haq W. (2009)
    10. Reconstituted micelle formation using reduced, carboxymethylated bovine kappa-casein and human beta-casein. (PubMed id 16947075)1, 9 Sood S.M....Slattery C.W. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1447 HGNC: 2447 AceView: CSN2 Ensembl:ENSG00000135222 euGenes: HUgn1447
    ECgene: CSN2 Kegg: 1447 H-InvDB: CSN2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CSN2 Pharmacogenomics, SNPs, Pathways
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/sptlt016.shtml

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CSN2 gene:
    Search GeneIP for patents involving CSN2

    GeneCards and IP:
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