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Aliases for CSN2 Gene

Aliases for CSN2 Gene

  • Casein Beta 2 3
  • CASB 3 4
  • Beta-Casein 3

External Ids for CSN2 Gene

Previous HGNC Symbols for CSN2 Gene

  • CASB

Previous GeneCards Identifiers for CSN2 Gene

  • GC04M070731
  • GC04M070869
  • GC04M071070
  • GC04M071136
  • GC04M071001
  • GC04M066618

Summaries for CSN2 Gene

Entrez Gene Summary for CSN2 Gene

  • This gene is a member of the beta casein family. There are two types of casein protein, beta (encoded by this gene) and kappa, both of which are secreted in human milk. Beta casein is the principal protein in human milk and the primary source of essential amino acids for a suckling infant. Beta and kappa casein proteins acting together form spherical micelles which bind within them important dietary minerals, such as calcium and phosphorous. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

GeneCards Summary for CSN2 Gene

CSN2 (Casein Beta) is a Protein Coding gene. Among its related pathways are PI-3K cascade and Signaling by GPCR. GO annotations related to this gene include calcium ion binding and enzyme inhibitor activity.

UniProtKB/Swiss-Prot for CSN2 Gene

  • Important role in determination of the surface properties of the casein micelles

Gene Wiki entry for CSN2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSN2 Gene

Genomics for CSN2 Gene

Regulatory Elements for CSN2 Gene

Genomic Location for CSN2 Gene

69,955,256 bp from pter
69,961,008 bp from pter
5,753 bases
Minus strand

Genomic View for CSN2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CSN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSN2 Gene

Proteins for CSN2 Gene

  • Protein details for CSN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q4VAZ9
    • Q9UCM5

    Protein attributes for CSN2 Gene

    226 amino acids
    Molecular mass:
    25382 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CSN2 Gene

Proteomics data for CSN2 Gene at MOPED

Post-translational modifications for CSN2 Gene

  • Form 1-P is phosphorylated once; half of the molecules are phosphorylated on Ser-24, half on Ser-25.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CSN2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CSN2 Gene

Domains for CSN2 Gene

Protein Domains for CSN2 Gene


Suggested Antigen Peptide Sequences for CSN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P05814
  • Belongs to the beta-casein family.
genes like me logo Genes that share domains with CSN2: view

No data available for Gene Families for CSN2 Gene

Function for CSN2 Gene

Molecular function for CSN2 Gene

GENATLAS Biochemistry: casein,beta
UniProtKB/Swiss-Prot Function: Important role in determination of the surface properties of the casein micelles

Gene Ontology (GO) - Molecular Function for CSN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004857 enzyme inhibitor activity TAS 2387396
GO:0005215 transporter activity IEA --
GO:0005509 calcium ion binding TAS 2387396
genes like me logo Genes that share ontologies with CSN2: view
genes like me logo Genes that share phenotypes with CSN2: view

Animal Models for CSN2 Gene

MGI Knock Outs for CSN2:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for CSN2 Gene

Localization for CSN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSN2 Gene


Subcellular locations from

Jensen Localization Image for CSN2 Gene COMPARTMENTS Subcellular localization image for CSN2 gene
Compartment Confidence
extracellular 5
nucleus 2
chloroplast 1
cytoskeleton 1
cytosol 1
golgi apparatus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CSN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 16502470
genes like me logo Genes that share ontologies with CSN2: view

Pathways for CSN2 Gene

genes like me logo Genes that share pathways with CSN2: view

Pathways by source for CSN2 Gene

1 Qiagen pathway for CSN2 Gene
1 KEGG pathway for CSN2 Gene
1 GeneGo (Thomson Reuters) pathway for CSN2 Gene

Gene Ontology (GO) - Biological Process for CSN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0006816 calcium ion transport TAS 2387396
GO:0007595 lactation IDA 7979373
GO:0043086 negative regulation of catalytic activity TAS 2387396
GO:1903488 negative regulation of lactation IBA --
genes like me logo Genes that share ontologies with CSN2: view

Compounds for CSN2 Gene

(55) Novoseek inferred chemical compound relationships for CSN2 Gene

Compound -log(P) Hits PubMed IDs
whey 75.4 23
imac 68.8 4
exorphins 66.1 1
sodium caseinate 65.7 4
glyceryl monooleate 59.7 8
genes like me logo Genes that share compounds with CSN2: view

Transcripts for CSN2 Gene

mRNA/cDNA for CSN2 Gene

(8) Additional mRNA sequences :
(3) REFSEQ mRNAs :
(8) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CSN2 Gene

Casein beta:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CSN2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CSN2 Gene

No ASD Table

Relevant External Links for CSN2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CSN2 Gene

mRNA expression in normal human tissues for CSN2 Gene

mRNA differential expression in normal tissues according to GTEx for CSN2 Gene

This gene is overexpressed in Breast - Mammary Tissue (52.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CSN2 Gene

SOURCE GeneReport for Unigene cluster for CSN2 Gene Hs.2242

mRNA Expression by UniProt/SwissProt for CSN2 Gene

Tissue specificity: Mammary gland specific. Secreted in milk
genes like me logo Genes that share expressions with CSN2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CSN2 Gene

Orthologs for CSN2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CSN2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CSN2 35
  • 99.41 (n)
  • 98.67 (a)
CSN2 36
  • 99 (a)
(Bos Taurus)
Mammalia CSN2 35
  • 71.9 (n)
  • 54.9 (a)
CSN2 36
  • 56 (a)
(Canis familiaris)
Mammalia CSN2 35
  • 79.87 (n)
  • 66.18 (a)
CSN2 36
  • 60 (a)
(Mus musculus)
Mammalia Csn2 35
  • 66.67 (n)
  • 49.19 (a)
Csn2 16
Csn2 36
  • 46 (a)
(Rattus norvegicus)
Mammalia Csn2 35
  • 64.64 (n)
  • 44.2 (a)
Species with no ortholog for CSN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CSN2 Gene

Gene Tree for CSN2 (if available)
Gene Tree for CSN2 (if available)

Paralogs for CSN2 Gene

No data available for Paralogs for CSN2 Gene

Variants for CSN2 Gene

Sequence variations from dbSNP and Humsavar for CSN2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs776857 -- 69,959,147(+) AAGGC(A/C)TTAAT intron-variant
rs776858 -- 69,959,747(+) AAGGC(C/T)GTCAG intron-variant
rs776859 -- 69,961,445(+) ataaa(C/T)gtaat upstream-variant-2KB
rs776860 -- 69,961,616(+) cccac(A/T)gccaa upstream-variant-2KB
rs776861 -- 69,962,072(+) ctcaa(G/T)gaaat upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CSN2 Gene

Variant ID Type Subtype PubMed ID
nsv879455 CNV Loss 21882294
dgv5628n71 CNV Loss 21882294
dgv5629n71 CNV Loss 21882294
nsv879460 CNV Gain 21882294

Relevant External Links for CSN2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSN2 Gene

Disorders for CSN2 Gene

(1) University of Copenhagen DISEASES for CSN2 Gene

(18) Novoseek inferred disease relationships for CSN2 Gene

Disease -log(P) Hits PubMed IDs
allergy milk 59.9 2
autoimmune thyroid disease 17.2 3
diabetes mellitus insulin-dependent 7.32 6
breast cancer 5.98 4
diabetes autoimmune 4.16 2
genes like me logo Genes that share disorders with CSN2: view

No data available for UniProtKB/Swiss-Prot for CSN2 Gene

Publications for CSN2 Gene

  1. Regional localization of human beta-casein gene (CSN2) to 4pter-q21. (PMID: 1577486) Menon R.S. … Ham R.G. (Genomics 1992) 2 3 23
  2. Derivatives of human beta-casein fragments (54-59) exhibit highly potent immunosuppressant activity. (PMID: 19463972) Puri A. … Haq W. (Int. Immunopharmacol. 2009) 3 23
  3. Kappa-casein and beta-caseins in human milk micelles: structural studies. (PMID: 7979373) Dev B.C. … Slattery C.W. (Arch. Biochem. Biophys. 1994) 3 23
  4. Cloning and sequencing of a cDNA encoding human milk beta-casein. (PMID: 2387396) Loennerdal B. … Hernell O. (FEBS Lett. 1990) 3 4
  5. Human beta-casein: partial cDNA sequence and apparent polymorphism. (PMID: 2717418) Menon R.S. … Ham R.G. (Nucleic Acids Res. 1989) 3 4

Products for CSN2 Gene

Sources for CSN2 Gene

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