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CSK Gene

protein-coding   GIFtS: 72
GCID: GC15P075075

C-Src Tyrosine Kinase

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
C-Src Tyrosine Kinase1 2
Protein-Tyrosine Kinase CYL2 3
C-Src Kinase2 3
EC 2.7.10.23 8
Tyrosine-Protein Kinase CSK2
EC 2.7.108

External Ids:    HGNC: 24441   Entrez Gene: 14452   Ensembl: ENSG000001036537   OMIM: 1240955   UniProtKB: P412403   

Export aliases for CSK gene to outside databases

Previous GC identifers: GC15M070982 GC15M068251 GC15P072650 GC15P072790 GC15P072861 GC15P051872


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CSK Gene:
CSK (c-src tyrosine kinase) is a protein-coding gene. GO annotations related to this gene include protein tyrosine kinase activity and identical protein binding. An important paralog of this gene is TEC.

UniProtKB/Swiss-Prot: CSK_HUMAN, P41240
Function: Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth,
differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails
of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family
members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in
an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane
proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors,
including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several
positive effectors such as FYN or LCK

Gene Wiki entry for CSK (C-src tyrosine kinase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CSK gene promoter:
         p53   LCR-F1   Nkx5-1   N-Myc   HEN1   E2F-1   E2F   POU2F1   POU2F1a   POU2F1b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CSK promoter sequence
   Search Chromatin IP Primers for CSK

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CSK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q24.1   Ensembl cytogenetic band:  15q24.1   HGNC cytogenetic band: 15q24.1

CSK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CSK gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P075075:  view genomic region     (about GC identifiers)

Start:
75,074,398 bp from pter      End:
75,095,539 bp from pter
Size:
21,142 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CSK_HUMAN, P41240 (See protein sequence)
Recommended Name: Tyrosine-protein kinase CSK  
Size: 450 amino acids; 50704 Da
Subunit: Homodimer (via SH3-domain). Interacts with PTPN8 (By similarity). Interacts with phosphorylated SIT1,
PAG1, LIME1 and TGFB1I1; these interactions serve to recruit CSK to the membrane where it can phosphorylate and
inhibit Src-family kinases. Interacts with SRCIN1. Interacts with RHOH. Interacts (via SH2 domain) with SCIMP
6 PDB 3D structures from and Proteopedia for CSK:
1BYG (3D)        1CSK (3D)        3D7T (3D)        3D7U (3D)        3EAC (3D)        3EAZ (3D)    
Secondary accessions: Q2M3N2 Q6FGZ6

Explore the universe of human proteins at neXtProt for CSK: NX_P41240

Explore proteomics data for CSK at MOPED

Post-translational modifications: 

  • Phosphorylated at Ser-364 by PKA, leading to increased activity. Autophosphorylated1
  • Ubiquitination2 at Lys193, Lys196, Lys329, Lys337
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CSK (P41240) (see all 16)
     EAMEYLE  RDLAARN  KWTAPEA  FVHRDLA 


    See CSK Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001120662.1  NP_004374.1  

    ENSEMBL proteins: 
     ENSP00000220003   ENSP00000414764   ENSP00000457497   ENSP00000457714   ENSP00000454906  
     ENSP00000454640   ENSP00000438808  
    Reactome Protein details: P41240

    CSK Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant CSK Protein
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for CSK
    OriGene Purified Proteins for CSK
    OriGene Protein Over-expression Lysate for CSK
    OriGene MassSpec for CSK
    OriGene Custom Protein Services for CSK
    GenScript Custom Purified and Recombinant Proteins Services for CSK
    Novus Biologicals CSK Proteins
    Novus Biologicals CSK Lysates
    Sino Biological Recombinant Protein for CSK
    Sino Biological Cell Lysate for CSK
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CSK

     
    Search eBioscience for Proteins for CSK 

     
    antibodies-online proteins for CSK (9 products) 

     
    antibodies-online peptides for CSK

    CSK Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CSK
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for CSK 
    OriGene Antibodies for CSK
    OriGene Custom Antibody Services for CSK
    Novus Biologicals CSK Antibodies
    Abcam antibodies for CSK
    Cloud-Clone Corp. Antibodies for CSK
    ThermoFisher Antibody for CSK
    LSBio Antibodies in human, mouse, rat for CSK
    antibodies-online antibodies for CSK (121 products) 

    CSK Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CSK
    Browse R&D Systems for biochemical assays
    GenScript CSK-Activity-based Kinase Assay for Compound Screening
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CSK
    Cloud-Clone Corp. CLIAs for CSK
    Search eBioscience for ELISAs for CSK 
    antibodies-online kits for CSK (12 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SH2D: SH2 domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: c-src tyrosine kinase
    Csk family

    Selected InterPro protein domains (see all 8):
     IPR017441 Protein_kinase_ATP_BS
     IPR011009 Kinase-like_dom
     IPR001452 SH3_domain
     IPR000719 Prot_kinase_dom
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry P41240

    ProtoNet protein and cluster: P41240

    3 Blocks protein domains:
    IPB000980 SH2 domain signature
    IPB001452 SH3 domain signature
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: CSK_HUMAN, P41240
    Domain: The architecture of this protein is similar to that of Src-family kinases (SFKs) with one N-terminal SH3
    domain, one SH2 domain, and a C-terminal kinase domain
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 SH2 domain
    Similarity: Contains 1 SH3 domain


    Find genes that share domains with CSK           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CSK_HUMAN, P41240
    Function: Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth,
    differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails
    of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family
    members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in
    an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane
    proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors,
    including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several
    positive effectors such as FYN or LCK
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

         Genatlas biochemistry entry for CSK:
    tyrosine kinase,SRC downregulating (putative antioncogene)

         Enzyme Numbers (IUBMB): EC 2.7.10.21 2 EC 2.7.102

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity TAS--
    GO:0004715non-membrane spanning protein tyrosine kinase activity IEA--
    GO:0005515protein binding IPI10026153
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with CSK           About GenesLikeMe


    Phenotypes:
         13 GenomeRNAi human phenotypes for CSK:
     Cell division defect  Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica  
     Decreased Salmonella enterica   Decreased Salmonella-containin  Decreased Wnt reporter activit  Decreased focal adhesion (FA)  
     Decreased substrate adherent c  Increased S DNA content  Increased mitotic index  Proliferating cells 
     Wnt reporter downregulated 

         15 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Csk):
     behavior/neurological  cardiovascular system  cellular  craniofacial  embryogenesis 
     growth/size/body  hearing/vestibular/ear  hematopoietic system  immune system  mortality/aging 
     nervous system  normal  respiratory system  taste/olfaction  vision/eye 

    Find genes that share phenotypes with CSK           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CSK: Csktm2Tara Csktm1Sor

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CSK
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CSK

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CSK
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CSK

    miRNA
    Products:
        
    miRTarBase miRNAs that target CSK:
    hsa-mir-140-5p (MIRT003960), hsa-mir-1180-3p (MIRT035928), hsa-mir-24-3p (MIRT030606)

    Block miRNA regulation of human, mouse, rat CSK using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CSK (see all 27):
    hsa-miR-194* hsa-miR-578 hsa-miR-342-3p hsa-miR-371-5p hsa-miR-373* hsa-miR-548a-3p hsa-miR-629* hsa-miR-654-5p
    SwitchGear 3'UTR luciferase reporter plasmidCSK 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CSK
    Predesigned siRNA for gene silencing in human, mouse, rat CSK

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CSK

    Clone
    Products:
         
    OriGene clones in human, mouse for CSK (see all 12)
    OriGene ORF clones in mouse, rat for CSK
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CSK (NM_001127190)
    Sino Biological Human cDNA Clone for CSK
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CSK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSK
    Addgene plasmids for CSK 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CSK
    Browse ESI BIO Cell Lines and PureStem Progenitors for CSK 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSK


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CSK_HUMAN, P41240: Cytoplasm (By similarity). Cell membrane (By similarity). Note=Mainly cytoplasmic, also
    present in lipid rafts (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    cytosol4
    golgi apparatus4
    plasma membrane4
    nucleus2
    endoplasmic reticulum1
    endosome1
    extracellular1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm TAS8890164
    GO:0005794Golgi apparatus ----
    GO:0005813centrosome ----
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--

    Find genes that share ontologies with CSK           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CSK About   (see all 28)  
    See pathways by source

    SuperPathContained pathways About
    1Signaling by FGFR
    Signaling by EGFR0.83
    Signaling by EGFR in Cancer0.82
    2Integrin alphaIIb beta3 signaling
    Integrin alphaIIb beta3 signaling0.73
    Platelet Aggregation (Plug Formation)0.73
    3Translocation of ZAP-70 to Immunological synapse
    Phosphorylation of CD3 and TCR zeta chains0.83
    PD-1 signaling0.72
    4ICos-ICosL Pathway in T-Helper Cell
    ICos-ICosL Pathway in T-Helper Cell0.66
    CD28 Signaling in T-Helper Cell0.66
    5TCR signaling in naive CD4+ T cells
    TCR signaling in naive CD8+ T cells0.64
    TCR signaling in naive CD4+ T cells0.64


    Find genes that share SuperPaths with CSK           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CSK (see all 7)
        Paxillin Interactions
    EGF Pathway
    FAK1 Signaling
    ICos-ICosL Pathway in T-Helper Cell
    TCR Signaling

    1 Cell Signaling Technology (CST) Pathway for CSK
        Tyrosine Kinases / Adaptors

    Selected BioSystems Pathways for CSK (see all 10)
        Integrin-mediated cell adhesion
    EGFR1 Signaling Pathway
    Regulation of Actin Cytoskeleton
    B Cell Receptor Signaling Pathway
    TCR signaling in naive CD4+ T cells


    4 Reactome Pathways for CSK
        GAB1 signalosome
    Integrin alphaIIb beta3 signaling
    PD-1 signaling
    Phosphorylation of CD3 and TCR zeta chains

    1 PharmGKB Pathway for CSK
        VEGF Signaling Pathway

    1 Kegg Pathway  (Kegg details for CSK):
        Epithelial cell signaling in Helicobacter pylori infection

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CSK
    Interactions:

        GeneGlobe Interaction Network for CSK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CSK (P412401, 2, 3 ENSP000002200034) via UniProtKB, MINT, STRING, and/or I2D (see all 733)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPRCP085751, 2, 3, ENSP000003563464EBI-1380630,EBI-1341 MINT-8310655 MINT-8310636 I2D: score=1 STRING: ENSP00000356346
    SRCP129312, 3, ENSP000003509414MINT-4980194 MINT-6169464 MINT-4980220 I2D: score=4 STRING: ENSP00000350941
    LILRB1Q8NHL62, 3, ENSP000003159974MINT-8027342 MINT-8027327 I2D: score=2 STRING: ENSP00000315997
    CAV1Q031352, 3, ENSP000003391914MINT-8027662 I2D: score=5 STRING: ENSP00000339191
    PAG1Q9NWQ82, 3, ENSP000002205974MINT-8028228 I2D: score=5 STRING: ENSP00000220597
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 22):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation TAS1945408
    GO:0007173epidermal growth factor receptor signaling pathway TAS--
    GO:0007420brain development IEA--
    GO:0007596blood coagulation TAS--
    GO:0008285negative regulation of cell proliferation IEA--

    Find genes that share ontologies with CSK           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CSK

    1 DrugBank Compound for CSK    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Staurosporine-- 62996-74-1target--17139284 17016423

    Selected Novoseek inferred chemical compound relationships for CSK gene (see all 59)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 87.9 445 8621646 (5), 17233630 (5), 9794236 (4), 10845713 (4) (see all 99)
    phosphotyrosine 68.1 16 7683128 (2), 7544435 (2), 7524477 (1), 9618476 (1) (see all 6)
    4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine 58.1 1 15451023 (1)
    pd153035 53.6 1 14704150 (1)
    ag 1478 50.5 1 10702246 (1)
    herbimycin a 50 1 7541536 (1)
    phosphatidylinositol 42.7 7 7524477 (1), 8626429 (1), 12837289 (1), 16530387 (1) (see all 7)
    rottlerin 42.2 2 18971559 (1), 16172428 (1)
    threonine 39.1 2 1379736 (1), 8813150 (1)
    pd 98,059 37.8 4 18971559 (1), 16172428 (1), 17283870 (1), 14704150 (1)



    Find genes that share compounds with CSK           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CSK gene (2 alternative transcripts): 
    NM_001127190.1  NM_004383.2  

    Unigene Cluster for CSK:

    C-src tyrosine kinase
    Hs.77793  [show with all ESTs]
    Unigene Representative Sequence: NM_004383
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000220003(uc010bkb.1 uc002ays.2 uc010bkc.1) ENST00000439220
    ENST00000563894(uc010bka.3) ENST00000567123 ENST00000569462 ENST00000567571
    ENST00000569915 ENST00000562066 ENST00000568329 ENST00000567135 ENST00000564216
    ENST00000566464 ENST00000569321 ENST00000563010 ENST00000309470
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CSK using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CSK (see all 27):
    hsa-miR-194* hsa-miR-578 hsa-miR-342-3p hsa-miR-371-5p hsa-miR-373* hsa-miR-548a-3p hsa-miR-629* hsa-miR-654-5p
    SwitchGear 3'UTR luciferase reporter plasmidCSK 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CSK
    Predesigned siRNA for gene silencing in human, mouse, rat CSK
    Clone
    Products:
         
    OriGene clones in human, mouse for CSK (see all 12)
    OriGene ORF clones in mouse, rat for CSK
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CSK (NM_001127190)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CSK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSK
    Addgene plasmids for CSK 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CSK
    OriGene qSTAR qPCR primer pairs in human, mouse for CSK
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CSK
      QuantiTect SYBR Green Assays in human, mouse, rat CSK
      QuantiFast Probe-based Assays in human, mouse, rat CSK

    Additional mRNA sequence: 

    AB451288.1 AB451420.1 AK127672.1 AK223626.1 AK290531.1 AK297694.1 AK298245.1 AK309344.1 
    AK310136.1 AK312669.1 AY007162.1 BC104847.1 BC104875.1 BC106073.1 CR541960.1 X59932.1 
    X60114.1 

    12 DOTS entries:

    DT.445561  DT.101983024  DT.100794281  DT.121045785  DT.121045769  DT.86998996  DT.100794276  DT.100794279 
    DT.95335504  DT.97795792  DT.99978627  DT.95335507 

    Selected AceView cDNA sequences (see all 335):

    BM564164 BM456073 AI381828 BP367634 CB109729 BU168116 AW403810 BQ680437 
    AI857668 BM920681 BQ645407 BG328553 AI611642 AW401741 BM909570 BQ678773 
    BQ670890 BU860139 BG684389 BQ053616 BQ646349 BP334707 AI885605 BI871293 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CSK (see all 10)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b · 16c ·
    SP1:                                            -                       -                       -                       -                                       
    SP2:                    -     -     -           -                       -                       -                       -                                       
    SP3:        -           -     -     -           -                       -                       -                       -                                       
    SP4:                                                                                            -                       -                                       
    SP5:                                                                                                                    -                                       

    ExUns: 16d ^ 17a · 17b ^ 18a · 18b
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for CSK

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CSK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGACACCGC
    CSK Expression
    About this image

    CSK Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CSK Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.77793

    UniProtKB/Swiss-Prot: CSK_HUMAN, P41240
    Tissue specificity: Expressed in lung and macrophages

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CSK gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Csk1 , 5 c-src tyrosine kinase1, 5 90.07(n)1
    99.11(a)1
      9 (31.18 cM)5
    129881  NM_007783.21  NP_031809.21 
     576266465 
    chicken
    (Gallus gallus)
    Aves CSK1 c-src tyrosine kinase 84.59(n)
    93.33(a)
      396396  NM_205425.1  NP_990756.1 
    lizard
    (Anolis carolinensis)
    Reptilia CSK6
    c-src tyrosine kinase
    93(a)
    1 ↔ 1
    GL343721.1(10285-48380)
    African clawed frog
    (Xenopus laevis)
    Amphibia csk-A2 c-src tyrosine kinase 75.82(n)    AF052430.1 
    zebrafish
    (Danio rerio)
    Actinopterygii csk1 c-src tyrosine kinase 77.88(n)
    85.97(a)
      556454  NM_001077599.1  NP_001071067.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Csk1 , 3 protein amino acid phosphorylation
    protein tyrosine more3
    C-terminal Src kinase1
    61(a)3
    64.74(n)1
    63.46(a)1
      86E173
    413981  NM_176461.11  NP_788638.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y38H6C.203
    csk-11
    protein tyrosine kinase3
    csk-11
    31(a)3
    53.38(n)1
    53.07(a)1
      V(20539450-20543204)3
    2668171  NM_001026607.21  NP_001021778.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CDC156
    Protein kinase of the Mitotic Exit Network that is...
    8(a)
    1 → many
    I(172211-175135) YAR019C


    ENSEMBL Gene Tree for CSK (if available)
    TreeFam Gene Tree for CSK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CSK gene
    TEC2  FER2  ITK2  TXK2  FES2  DSTYK2  MATK2  BMX2  
    BTK2  
    Selected SIMAP similar genes for CSK using alignment to 6 protein entries:     CSK_HUMAN (see all proteins) (see all similar genes):
    lsk    NCK1    MATK    CRK    EPHA2    GRAP2
    BTK kinase deficient isoform 2    NCK2    BCR/ABL fusion    BMX    MET    MST1R
    GRAPL    FGFR2    ABL2    EPHA6    FGFR1    FGFR3

    Find genes that share paralogs with CSK           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CSK (see all 484)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs48866291,2
    C,F,H--75072558(-) CAAAGG/CCTTCT 2 -- us2k115Minor allele frequency- C:0.41NS EA NA WA CSA 791
    rs1492968441,2
    --75072588(+) TCTTGC/TAGGCT 2 -- us2k10--------
    rs1435713371,2
    --75073004(+) GGTTTA/TGGGGG 2 -- us2k10--------
    rs1162590451,2
    C,F--75073019(+) TCCTCC/GTGGCA 2 -- us2k11Minor allele frequency- G:0.03WA 118
    rs1380878101,2
    C--75073027(+) GCATCC/TGAGGC 2 -- us2k10--------
    rs352901211,2
    C,F--75073121(+) CTTCAT/AGCTTA 2 -- us2k17Minor allele frequency- A:0.08NS WA EA 422
    rs349529381,2
    C--75073130(+) TATTTT/GGTGTT 2 -- us2k15Minor allele frequency- G:0.01NS 184
    rs342827441,2
    C,F--75073172(+) CCCCCC/GAACCC 2 -- us2k16Minor allele frequency- G:0.04NS NA 304
    rs1426656541,2
    C--75073268(+) CCCTAC/TGCTGG 2 -- us2k10--------
    rs1462934091,2
    --75073316(+) TGTTCC/TCCGGT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for CSK (75074398 - 75095539 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CSK:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2749886CNV Deletion23290073
    esv2749883CNV Deletion23290073
    dgv344e201CNV Deletion23290073
    nsv904380CNV Loss21882294
    nsv833055CNV Loss17160897

    Human Gene Mutation Database (HGMD): CSK
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CSK
    DNA2.0 Custom Variant and Variant Library Synthesis for CSK

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 124095    OMIM disorders: --


    Find genes that share disorders with CSK           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CSK gene (see all 25)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 39.6 20 11445575 (4), 11278729 (1), 12753909 (1), 12941830 (1) (see all 15)
    colon cancer 37.5 10 14712234 (2), 20010872 (2), 11054667 (2), 15961079 (1) (see all 7)
    osteopetrosis 35.9 1 7688650 (1)
    colon carcinoma 31 2 7681838 (1), 11443610 (1)
    cancer 28.7 15 14712234 (3), 7533218 (2), 15194078 (1), 16243715 (1) (see all 10)
    tumors 24.8 27 11084024 (4), 10974196 (2), 16716300 (2), 11445575 (2) (see all 18)
    colon adenocarcinoma 22.7 1 11054667 (1)
    colon tumor 18.8 1 10974196 (1)
    metastasis 18.7 13 11054667 (3), 12941830 (2), 11278729 (1), 19734908 (1) (see all 8)
    pancreatic carcinoma 13.7 2 10845713 (1)

    Genetic Association Database (GAD): CSK
    Human Genome Epidemiology (HuGE) Navigator: CSK (20 documents)
    Tumor Gene Database (TGDB): CSK

    Export disorders for CSK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CSK gene, integrated from 10 sources (see all 551):
    (articles sorted by number of sources associating them with CSK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Activation of the COOH-terminal Src kinase (Csk) by cAMP-dependent protein kinase inhibits signaling through the T cell receptor. (PubMed id 11181701)1, 2, 9 Vang T.... Tasken K. (J. Exp. Med. 2001)
    2. Identification of csk tyrosine phosphorylation sites and a tyrosine residue important for kinase domain structure. (PubMed id 9148770)1, 2, 9 Joukov V....Bergman M. (Biochem. J. 1997)
    3. The c-src tyrosine kinase (CSK) gene, a potential antioncogene, localizes to human chromosome region 15q23----q25. (PubMed id 1377109)1, 3, 9 Armstrong E....Alitalo K. (Cytogenet. Cell Genet. 1992)
    4. p140Cap protein suppresses tumour cell properties, regulating Csk and Src kinase activity. (PubMed id 17525734)1, 2, 9 Di Stefano P.... Defilippi P. (EMBO J. 2007)
    5. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. (PubMed id 21909115)1, 4  ....Johnson T. (Nature 2011)
    6. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. (PubMed id 21909110)1, 4 Wain L.V....van Duijn C.M. (Nat. Genet. 2011)
    7. Blood pressure and hypertension are associated with 7 loci in the Japanese population. (PubMed id 20479155)1, 4 Takeuchi F....Kato N. (Circulation 2010)
    8. Recapitulation of two genomewide association studies on blood pressure and essential hypertension in the Korean population. (PubMed id 20414254)1, 4 Hong K.W....Oh B. (J. Hum. Genet. 2010)
    9. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (Vaccine 2010)
    10. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (Carcinogenesis 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1445 HGNC: 2444 AceView: CSK Ensembl:ENSG00000103653 euGenes: HUgn1445
    ECgene: CSK Kegg: 1445 H-InvDB: CSK

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CSK Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CSK Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/csk/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CSK gene:
    Search GeneIP for patents involving CSK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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