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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CSK Gene

protein-coding   GIFtS: 72
GCID: GC15P075075

C-Src Tyrosine Kinase

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
C-Src Tyrosine Kinase1 2
Protein-Tyrosine Kinase CYL2 3
C-Src Kinase2 3
EC 2.7.10.23 8
Tyrosine-Protein Kinase CSK2
EC 2.7.108

External Ids:    HGNC: 24441   Entrez Gene: 14452   Ensembl: ENSG000001036537   OMIM: 1240955   UniProtKB: P412403   

Export aliases for CSK gene to outside databases

Previous GC identifers: GC15M070982 GC15M068251 GC15P072650 GC15P072790 GC15P072861 GC15P051872


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CSK Gene: 
CSK (c-src tyrosine kinase) is a protein-coding gene. Diseases associated with CSK include tongue cancer, and endocervicitis, and among its related super-pathways are Signaling by FGFR and Phosphorylation of CD3 and TCR zeta chains. GO annotations related to this gene include protein phosphatase binding and protein C-terminus binding. An important paralog of this gene is DSTYK.

UniProtKB/Swiss-Prot: CSK_HUMAN, P41240
Function: Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth,
differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails
of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family
members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in
an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane
proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors,
including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several
positive effectors such as FYN or LCK

Gene Wiki entry for CSK (C-src tyrosine kinase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NT_010194.17  NC_018926.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CSK gene promoter:
         p53   LCR-F1   Nkx5-1   N-Myc   HEN1   E2F-1   E2F   POU2F1   POU2F1a   POU2F1b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CSK promoter sequence
   Search SABiosciences Chromatin IP Primers for CSK

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CSK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q24.1   Ensembl cytogenetic band:  15q24.1   HGNC cytogenetic band: 15q24.1

CSK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CSK gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P075075:  view genomic region     (about GC identifiers)

Start:
75,074,398 bp from pter      End:
75,095,539 bp from pter
Size:
21,142 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CSK_HUMAN, P41240 (See protein sequence)
Recommended Name: Tyrosine-protein kinase CSK  
Size: 450 amino acids; 50704 Da
Subunit: Homodimer (via SH3-domain). Interacts with PTPN8 (By similarity). Interacts with phosphorylated SIT1,
PAG1, LIME1 and TGFB1I1; these interactions serve to recruit CSK to the membrane where it can phosphorylate and
inhibit Src-family kinases. Interacts with SRCIN1. Interacts with RHOH. Interacts (via SH2 domain) with SCIMP
Subcellular location: Cytoplasm (By similarity). Cell membrane (By similarity). Note=Mainly cytoplasmic, also
present in lipid rafts (By similarity)
6 PDB 3D structures from and Proteopedia for CSK:
1BYG (3D)        1CSK (3D)        3D7T (3D)        3D7U (3D)        3EAC (3D)        3EAZ (3D)    
Secondary accessions: Q2M3N2 Q6FGZ6

Explore the universe of human proteins at neXtProt for CSK: NX_P41240

Explore proteomics data for CSK at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated at Ser-364 by PKA, leading to increased activity. Autophosphorylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P41240

  • 4/16 DME Specific Peptides for CSK (P41240) (see all 16)
     EAMEYLE  RDLAARN  KWTAPEA  FVHRDLA 

    CSK Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CSK Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001120662.1  NP_004374.1  

    ENSEMBL proteins: 
     ENSP00000220003   ENSP00000414764   ENSP00000457497   ENSP00000457714   ENSP00000454906  
     ENSP00000454640   ENSP00000438808  
    Reactome Protein details: P41240
    Human Recombinant Protein Products for CSK: 
    EMD Millipore Purified and/or Recombinant CSK Protein
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for CSK
    OriGene Purified Proteins for CSK
    OriGene Protein Over-expression Lysate for CSK
    OriGene MassSpec for CSK 
    OriGene Custom Protein Services for CSK
    GenScript Purified and Recombinant Proteins for CSK
    Novus Biologicals CSK Proteins
    Novus Biologicals CSK Lysates
    Sino Biological Recombinant Protein for CSK
    Sino Biological Cell Lysate for CSK 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CSK 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm TAS8890164
    GO:0005794Golgi apparatus IDA--
    GO:0005813centrosome IDA--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--

    CSK for ontologies           About GeneDecksing



    CSK Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CSK
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for CSK 
    OriGene Antibodies for CSK
    OriGene Custom Antibody Services for CSK
    GenScript Custom Superior Antibodies Services for CSK
    Novus Biologicals CSK Antibodies
    Abcam antibodies for CSK
    Cloud-Clone Corp. Antibodies for CSK 
    ThermoFisher Antibody for CSK
    LSBio Antibodies in human, mouse, rat for CSK 

    Assay Products for CSK: 
    EMD Millipore Kits and Assays for the Analysis of CSK
    OriGene Custom Assay Services for CSK
    Browse R&D Systems for biochemical assays
    GenScript CSK-Activity-based Kinase Assay for Compound Screening
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CSK 
    Cloud-Clone Corp. CLIAs for CSK


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SH2D: SH2 domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: c-src tyrosine kinase 
    Csk family

    5/8 InterPro protein domains (see all 8):
     IPR017441 Protein_kinase_ATP_BS
     IPR011009 Kinase-like_dom
     IPR001452 SH3_domain
     IPR000719 Prot_kinase_cat_dom
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry P41240

    ProtoNet protein and cluster: P41240

    3 Blocks protein domains:
    IPB000980 SH2 domain signature
    IPB001452 SH3 domain signature
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: CSK_HUMAN, P41240
    Domain: The architecture of this protein is similar to that of Src-family kinases (SFKs) with one N-terminal SH3
    domain, one SH2 domain, and a C-terminal kinase domain
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 SH2 domain
    Similarity: Contains 1 SH3 domain


    CSK for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CSK_HUMAN, P41240
    Function: Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth,
    differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails
    of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family
    members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in
    an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane
    proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors,
    including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several
    positive effectors such as FYN or LCK
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

         Genatlas biochemistry entry for CSK:
    tyrosine kinase,SRC downregulating (putative antioncogene)

         Enzyme Numbers (IUBMB): EC 2.7.10.21 2 EC 2.7.102

         Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity TAS--
    GO:0004715non-membrane spanning protein tyrosine kinase activity IEA--
    GO:0005515protein binding IPI10790433
    GO:0005524ATP binding IEA--
         
    CSK for ontologies           About GeneDecksing


    Phenotypes:
         13 GenomeRNAi human phenotypes for CSK:
     Cell division defect  Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica  
     Decreased Salmonella enterica   Decreased Salmonella-containin  Decreased Wnt reporter activit  Decreased focal adhesion (FA)  
     Decreased substrate adherent c  Increased S DNA content  Increased mitotic index  Proliferating cells 
     Wnt reporter downregulated 

         13 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Csk):
     behavior/neurological  cardiovascular system  cellular  craniofacial  embryogenesis 
     growth/size  hearing/vestibular/ear  hematopoietic system  immune system  mortality/aging 
     nervous system  normal  vision/eye 

    CSK for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CSK: Csktm2Tara Csktm1Sor

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CSK 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CSK

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CSK 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CSK 

    miRNA
    Products:
        
    miRTarBase miRNAs that target CSK:
    hsa-mir-140-5p (MIRT003960)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CSK
    8/27 QIAGEN miScript miRNA Assays for microRNAs that regulate CSK (see all 27):
    hsa-miR-194* hsa-miR-578 hsa-miR-342-3p hsa-miR-371-5p hsa-miR-373* hsa-miR-548a-3p hsa-miR-629* hsa-miR-654-5p
    SwitchGear 3'UTR luciferase reporter plasmidCSK 3' UTR sequence
    Inhib. RNA
    Products:
        
    EMD Millipore RNAi Products for the Analysis of CSK Gene knock-down
    OriGene RNAi products in human, mouse, rat for CSK
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CSK

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CSK
    Sirion Biotech Customized adenovirus for overexpression of CSK

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CSK (see all 14)
    OriGene ORF clones in mouse, rat for CSK
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CSK (NM_001127190)
    Sino Biological Human cDNA Clone for CSK
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CSK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSK
    Sirion Biotech Customized lentivirus for stable overexpression of CSK 
                         Customized lentivirus expression plasmids for stable overexpression of CSK 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CSK
    Search LifeMap BioReagents cell lines for CSK
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSK


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CSK About   (see all 29)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Signaling by FGFR
    Signaling by EGFR0.84
    Signaling by EGFR in Cancer0.83
    2Translocation of ZAP-70 to Immunological synapse
    Phosphorylation of CD3 and TCR zeta chains0.85
    PD-1 signaling0.77
    3Integrin alphaIIb beta3 signaling
    Integrin alphaIIb beta3 signaling0.73
    Platelet Aggregation (Plug Formation)0.73
    4ICos-ICosL Pathway in T-Helper Cell
    ICos-ICosL Pathway in T-Helper Cell0.66
    CD28 Signaling in T-Helper Cell0.66
    5TCR signaling in naive CD4+ T cells
    TCR signaling in naive CD4+ T cells0.64
    TCR signaling in naive CD8+ T cells0.64

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CSK (see all 7)
        Paxillin Interactions
    EGF Pathway
    FAK1 Signaling
    ICos-ICosL Pathway in T-Helper Cell
    TCR Signaling

    1 Cell Signaling Technology (CST) Pathway for CSK
        Tyrosine Kinases / Adaptors

    5/10 BioSystems Pathways for CSK (see all 10)
        EGFR1 Signaling Pathway
    Integrin-mediated cell adhesion
    Regulation of Actin Cytoskeleton
    B Cell Receptor Signaling Pathway
    Signaling events mediated by PTP1B


    5/16        Reactome Pathways for CSK (see all 16)
        Costimulation by the CD28 family
    Signaling by EGFR in Cancer
    Disease
    GAB1 signalosome
    PD-1 signaling

    1 PharmGKB Pathway for CSK
        VEGF Signaling Pathway

    1         Kegg Pathway  (Kegg details for CSK):
        Epithelial cell signaling in Helicobacter pylori infection


    CSK for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CSK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/732 Interacting proteins for CSK (P412401, 2, 3 ENSP000002200034) via UniProtKB, MINT, STRING, and/or I2D (see all 732)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SRCP129312, 3, ENSP000003509414MINT-4980194 MINT-6169464 MINT-4980220 I2D: score=4 STRING: ENSP00000350941
    LILRB1Q8NHL62, 3, ENSP000003159974MINT-8027342 MINT-8027327 I2D: score=2 STRING: ENSP00000315997
    PTPRCP085752, 3, ENSP000003563464MINT-8310655 MINT-8310636 I2D: score=1 STRING: ENSP00000356346
    CAV1Q031352, 3, ENSP000003391914MINT-8027662 I2D: score=5 STRING: ENSP00000339191
    PAG1Q9NWQ82, 3, ENSP000002205974MINT-8028228 I2D: score=5 STRING: ENSP00000220597
    About this table

    Gene Ontology (GO): 5/21 biological process terms (GO ID links to tree view) (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation TAS1945408
    GO:0007173epidermal growth factor receptor signaling pathway TAS--
    GO:0007420brain development IEA--
    GO:0007596blood coagulation TAS--
    GO:0008285negative regulation of cell proliferation IEA--

    CSK for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CSK for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CSK

    1 DrugBank Compound for CSK    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Staurosporine-- 62996-74-1target--17139284 17016423

    10/59 Novoseek inferred chemical compound relationships for CSK gene (see all 59)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 87.9 445 8621646 (5), 17233630 (5), 9794236 (4), 10845713 (4) (see all 99)
    phosphotyrosine 68.1 16 7683128 (2), 7544435 (2), 7524477 (1), 9618476 (1) (see all 6)
    4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine 58.1 1 15451023 (1)
    pd153035 53.6 1 14704150 (1)
    ag 1478 50.5 1 10702246 (1)
    herbimycin a 50 1 7541536 (1)
    phosphatidylinositol 42.7 7 7524477 (1), 8626429 (1), 12837289 (1), 16530387 (1) (see all 7)
    rottlerin 42.2 2 18971559 (1), 16172428 (1)
    threonine 39.1 2 1379736 (1), 8813150 (1)
    pd 98,059 37.8 4 18971559 (1), 16172428 (1), 17283870 (1), 14704150 (1)

    Search CenterWatch for drugs/clinical trials and news about CSK

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CSK gene (2 alternative transcripts): 
    NM_001127190.1  NM_004383.2  

    Unigene Cluster for CSK:

    C-src tyrosine kinase
    Hs.77793  [show with all ESTs]
    Unigene Representative Sequence: NM_004383
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000220003(uc010bkb.1 uc002ays.2 uc010bkc.1) ENST00000439220
    ENST00000563894(uc010bka.3) ENST00000567123 ENST00000569462 ENST00000567571
    ENST00000569915 ENST00000562066 ENST00000568329 ENST00000567135 ENST00000564216
    ENST00000566464 ENST00000569321 ENST00000563010 ENST00000309470
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CSK
    8/27 QIAGEN miScript miRNA Assays for microRNAs that regulate CSK (see all 27):
    hsa-miR-194* hsa-miR-578 hsa-miR-342-3p hsa-miR-371-5p hsa-miR-373* hsa-miR-548a-3p hsa-miR-629* hsa-miR-654-5p
    SwitchGear 3'UTR luciferase reporter plasmidCSK 3' UTR sequence
    Inhib. RNA
    Products:
         
    EMD Millipore RNAi Products for the Analysis of CSK Gene knock-down
    OriGene RNAi products in human, mouse, rat for CSK
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CSK
    Clone
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    OriGene clones in human, mouse for CSK (see all 14)
    OriGene ORF clones in mouse, rat for CSK
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CSK (NM_001127190)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CSK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSK
    Sirion Biotech Customized lentivirus for stable overexpression of CSK 
                         Customized lentivirus expression plasmids for stable overexpression of CSK 
    Primer
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    OriGene qPCR primer pairs and template standards for CSK
    OriGene qSTAR qPCR primer pairs in human, mouse for CSK
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CSK
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CSK
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CSK

    Additional mRNA sequence: 

    AB451288.1 AB451420.1 AK127672.1 AK223626.1 AK290531.1 AK297694.1 AK298245.1 AK309344.1 
    AK310136.1 AK312669.1 AY007162.1 BC104847.1 BC104875.1 BC106073.1 CR541960.1 X59932.1 
    X60114.1 

    12 DOTS entries:

    DT.445561  DT.101983024  DT.100794281  DT.121045785  DT.121045769  DT.86998996  DT.100794276  DT.100794279 
    DT.95335504  DT.97795792  DT.99978627  DT.95335507 

    24/335 AceView cDNA sequences (see all 335):

    BQ056693 BQ680437 BQ646349 BE383338 BM920681 BM762901 BG328553 BG683077 
    BM456073 CB850886 BQ053738 AW403810 AI370720 BM909570 BM709046 BQ918972 
    BU169133 BU838081 CK430451 BU190493 BP334707 BI871293 BM917940 BQ676441 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for CSK (see all 10)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b · 16c ·
    SP1:                                            -                       -                       -                       -                                       
    SP2:                    -     -     -           -                       -                       -                       -                                       
    SP3:        -           -     -     -           -                       -                       -                       -                                       
    SP4:                                                                                            -                       -                                       
    SP5:                                                                                                                    -                                       

    ExUns: 16d ^ 17a · 17b ^ 18a · 18b
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for CSK

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CSK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGACACCGC
    CSK Expression
    About this image


    See CSK Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CSK

    SOURCE GeneReport for Unigene cluster: Hs.77793

    UniProtKB/Swiss-Prot: CSK_HUMAN, P41240
    Tissue specificity: Expressed in lung and macrophages

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CSK gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Csk1 , 5 c-src tyrosine kinase1, 5 90.07(n)1
    99.11(a)1
      9 (31.18 cM)5
    129881  NM_007783.21  NP_031809.21 
     576266465 
    chicken
    (Gallus gallus)
    Aves CSK1 c-src tyrosine kinase 84.59(n)
    93.33(a)
      396396  NM_205425.1  NP_990756.1 
    lizard
    (Anolis carolinensis)
    Reptilia CSK6
    Uncharacterized protein
    93(a)
    1 ↔ 1
    GL343721.1(10285-48380)
    African clawed frog
    (Xenopus laevis)
    Amphibia csk-A2 c-src tyrosine kinase 75.82(n)    AF052430.1 
    zebrafish
    (Danio rerio)
    Actinopterygii csk1 c-src tyrosine kinase 77.88(n)
    85.97(a)
      556454  NM_001077599.1  NP_001071067.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Csk1 , 3 protein amino acid phosphorylation
    protein tyrosine more3
    C-terminal Src kinase1
    61(a)3
    64.74(n)1
    63.46(a)1
      86E173
    413981  NM_176461.11  NP_788638.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y38H6C.203
    csk-11
    protein tyrosine kinase3
    Protein CSK-11
    31(a)3
    53.43(n)1
    53.19(a)1
      V(20539450-20543204)3
    2668171  NM_001026607.11  NP_001021778.11 


    ENSEMBL Gene Tree for CSK (if available)
    TreeFam Gene Tree for CSK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CSK gene
    DSTYK2  MATK2  FER2  FES2  
    18/58 SIMAP similar genes for CSK using alignment to 6 protein entries:     CSK_HUMAN (see all proteins) (see all similar genes):
    lsk    NCK1    MATK    CRK    EPHA2    GRAP2
    BTK kinase deficient isoform 2    NCK2    BCR/ABL fusion    BMX    MET    MST1R
    GRAPL    FGFR2    ABL2    EPHA6    FGFR1    FGFR3

    CSK for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/484 SNPs in CSK are shown (see all 484)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0416784
    ----see VAR_0416782 P L mis40--------
    rs48866291,2
    C,F,H--75072558(-) CAAAGG/CCTTCT 2 -- us2k115Minor allele frequency- C:0.41NS EA NA WA CSA 791
    rs1492968441,2
    --75072588(+) TCTTGC/TAGGCT 2 -- us2k10--------
    rs1435713371,2
    --75073004(+) GGTTTA/TGGGGG 2 -- us2k10--------
    rs1162590451,2
    C,F--75073019(+) TCCTCC/GTGGCA 2 -- us2k11Minor allele frequency- G:0.03WA 118
    rs1380878101,2
    C--75073027(+) GCATCC/TGAGGC 2 -- us2k10--------
    rs352901211,2
    C,F--75073121(+) CTTCAT/AGCTTA 2 -- us2k17Minor allele frequency- A:0.08NS WA EA 422
    rs349529381,2
    C--75073130(+) TATTTT/GGTGTT 2 -- us2k15Minor allele frequency- G:0.01NS 184
    rs342827441,2
    C,F--75073172(+) CCCCCC/GAACCC 2 -- us2k16Minor allele frequency- G:0.04NS NA 304
    rs1426656541,2
    C--75073268(+) CCCTAC/TGCTGG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for CSK (75074398 - 75095539 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CSK:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2749886CNV Deletion23290073
    esv2749883CNV Deletion23290073
    dgv344e201CNV Deletion23290073
    nsv904380CNV Loss21882294
    nsv833055CNV Loss17160897


    Human Gene Mutation Database (HGMD): CSK
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 124095    OMIM disorders: --

    20/44 diseases for CSK (see all 44):    About MalaCards
    tongue cancer    endocervicitis    osteopetrosis    noonan syndrome
    ductal carcinoma in situ    mantle cell lymphoma    wiskott-aldrich syndrome    pancreatic ductal adenocarcinoma
    cystic fibrosis    gout    kaposi's sarcoma    retinoblastoma
    pertussis    colon cancer    esophageal adenocarcinoma    colon adenocarcinoma
    essential hypertension    choroiditis    adenocarcinoma    pancreatitis


    CSK for disorders           About GeneDecksing

    10/25 Novoseek inferred disease relationships for CSK gene (see all 25)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 39.6 20 11445575 (4), 11278729 (1), 12753909 (1), 12941830 (1) (see all 15)
    colon cancer 37.5 10 14712234 (2), 20010872 (2), 11054667 (2), 15961079 (1) (see all 7)
    osteopetrosis 35.9 1 7688650 (1)
    colon carcinoma 31 2 7681838 (1), 11443610 (1)
    cancer 28.7 15 14712234 (3), 7533218 (2), 15194078 (1), 16243715 (1) (see all 10)
    tumors 24.8 27 11084024 (4), 10974196 (2), 16716300 (2), 11445575 (2) (see all 18)
    colon adenocarcinoma 22.7 1 11054667 (1)
    colon tumor 18.8 1 10974196 (1)
    metastasis 18.7 13 11054667 (3), 12941830 (2), 11278729 (1), 19734908 (1) (see all 8)
    pancreatic carcinoma 13.7 2 10845713 (1)

    Genetic Association Database (GAD): CSK
    Human Genome Epidemiology (HuGE) Navigator: CSK (20 documents)
    Tumor Gene Database (TGDB): CSK

    Export disorders for CSK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CSK gene, integrated from 9 sources (see all 544):
    (articles sorted by number of sources associating them with CSK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Activation of the COOH-terminal Src kinase (Csk) by cAMP-dependent protein kinase inhibits signaling through the T cell receptor. (PubMed id 11181701)1, 2, 9 Vang T....Tasken K. (2001)
    2. Identification of csk tyrosine phosphorylation sites and a tyrosine residue important for kinase domain structure. (PubMed id 9148770)1, 2, 9 Joukov V....Bergman M. (1997)
    3. The c-src tyrosine kinase (CSK) gene, a potential antioncogene, localizes to human chromosome region 15q23----q25. (PubMed id 1377109)1, 3, 9 Armstrong E....Alitalo K. (1992)
    4. p140Cap protein suppresses tumour cell properties, regulating Csk and Src kinase activity. (PubMed id 17525734)1, 2, 9 Di Stefano P....Defilippi P. (2007)
    5. Genetic variants in novel pathways influence blood pre ssure and cardiovascular disease risk. (PubMed id 21909115)1, 4  ....Johnson T. (2011)
    6. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. (PubMed id 21909110)1, 4 Wain L.V....van Duijn C.M. (2011)
    7. Blood pressure and hypertension are associated with 7 loci in the Japanese population. (PubMed id 20479155)1, 4 Takeuchi F....Kato N. (2010)
    8. Recapitulation of two genomewide association studies on blood pressure and essential hypertension in the Korean population. (PubMed id 20414254)1, 4 Hong K.W....Oh B. (2010)
    9. Polymorphisms in innate immunity genes and patients r esponse to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (2010)
    10. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1445 HGNC: 2444 AceView: CSK Ensembl:ENSG00000103653 euGenes: HUgn1445
    ECgene: CSK Kegg: 1445 H-InvDB: CSK

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CSK Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CSK Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/csk/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CSK gene:
    Search GeneIP for patents involving CSK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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