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CSK Gene

protein-coding GIFtS: 71

GC15P072861

c-src tyrosine kinase
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 2.7.10.2 ^³
MGC117393 ^²

Descriptions
C-SRC kinase ^³
Protein-tyrosine kinase CYL ^³
c-src tyrosine kinase ^²

External Ids
HGNC: 2444¹
Entrez Gene: 1445²
UniProtKB: P41240³
Ensembl: ENSG00000103653⁷

Search outside databases for aliases for CSK gene

Previous GC identifers: GC15M070982 GC15M068251 GC15P072650 GC15P072790

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: CSK_HUMAN, P41240

Function: Specifically phosphorylates 'Tyr-504' on LCK, which acts as a negative regulatory site.

Can also act on the LYN and FYN kinases

Gene Wiki entry for CSK (C-src_tyrosine_kinase)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CSK gene

Entrez Gene cytogenetic band: 15q23-q25 Ensembl cytogenetic band: 15q24.1 HGNC cytogenetic band: 15q24.1

CSK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15P072861: (about GC identifiers)

Start:	72,861,768 bp from pter
End:	72,882,558 bp from pter
Size:	20,791 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000015.8 NT_010194.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: CSK_HUMAN, P41240 (See protein sequence)

Recommended Name: Tyrosine-protein kinase CSK

Size: 450 amino acids; 50704 Da

Subunit: Interacts with PTPN8 (By similarity). Interacts with phosphorylated SIT1, PAG1, LIME1 and

TGFB1I1

Subcellular location: Cytoplasm (By similarity). Cell membrane (By similarity). Note=Mainly

cytoplasmic, also present in lipid rafts (By similarity)

PDB structures from and Proteopedia :

1BYG (3D)

1CSK (3D)

3D7T (3D)

3D7U (3D)

Secondary accessions: Q2M3N2 Q6FGZ6

Post-translational modifications:

Autophosphorylation of Tyr-304 occurs only at abnormally high CSK concentrations in vitro¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001120662.1 NP_004374.1

ENSEMBL proteins:

ENSP00000220003

Human Recombinant Proteins

	Invitrogen human recombinant proteins for CSK
	Millipore Purified and/or Recombinant CSK Protein
	Sigma-Aldrich Proteins for CSK
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for CSK
	Recombinant Proteins from Abcam (CSK)
	Human Recombinant Proteins from Abnova (CSK)

OriGene Purified Recombinant Human Protein: CSK

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	TAS	8890164
GO:0005886	plasma membrane	IPI	10790433
GO:0005911	cell-cell junction	IEA	--

About this table

Antibodies for CSK:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of CSK
	Sigma-Aldrich Antibody Arrays and Antibodies for CSK
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for CSK
	Antibodies from Abcam (CSK), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (CSK)
	Novus Biologicals Antibodies for CSK

Assays for CSK:

	Invitrogen Assays for CSK
	Millipore Kits and Assays for the Analysis of CSK
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P41240

ProtoNet protein and cluster: P41240

3 Blocks protein families:

IPB000980 SH2 domain signature

IPB001452 SH3 domain signature

IPB008266 Tyrosine protein kinase

UniProtKB/Swiss-Prot: CSK_HUMAN, P41240

Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily

Similarity: Contains 1 protein kinase domain

Similarity: Contains 1 SH2 domain

Similarity: Contains 1 SH3 domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CSK)
		Millipore RNAi Products for the Analysis of CSK Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (CSK)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001127190

Applied Biosystems Silencer® siRNAs for CSK

Sigma-Aldrich siRNA and siRNA Panels for CSK

Sigma-Aldrich shRNA Panels and shRNA for CSK

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001127190
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001127190
untagged cDNA clones in CMV expression vector (see all 3): NM_001127190

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004383

UniProtKB/Swiss-Prot: CSK_HUMAN, P41240

Function: Specifically phosphorylates 'Tyr-504' on LCK, which acts as a negative regulatory site.

Can also act on the LYN and FYN kinases

Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

Enzyme Number (IUBMB): EC 2.7.10.2

Genatlas biochemistry entry for CSK:

tyrosine kinase,SRC downregulating (putative antioncogene)

12 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Csk):

	cellular	craniofacial	embryogenesis	growth/size
hearing/vestibular/ear	hematopoietic system	immune system	lethality-prenatal/perinatal	nervous system
normal	vision/eye

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0004715	non-membrane spanning protein tyrosine kinase activity	IEA	--
GO:0005524	ATP binding	IEA	--
GO:0008022	protein C-terminus binding	TAS	8890164
GO:0016740	transferase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/6 Sigma-Aldrich "Your Favorite Gene" Pathways for CSK (Your Favorite Gene powered by Ingenuity) (see all 6 )

iCOS-iCOSL Signaling in T Helper Cells
B Cell Receptor Signaling
CD28 Signaling in T Helper Cells
T Cell Receptor Signaling
RAR Activation

GeneDecks CSK for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for CSK

5/124 Interacting proteins for CSK (ENSP00000220003³ P41240^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 124 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PTPRC	P08575¹	STRING (score=.973) EBI-1380630, EBI-1341
G3BP1	Q13283²	STRING (score=.74) MINT-61272 MINT-61275 MINT-61273
SRC	P12931²	STRING (score=.995) MINT-4980194 MINT-6169464 MINT-4980220
PXN	P49023²	STRING (score=.999) MINT-6169431 MINT-6169464
EGFR	P00533²	STRING (score=.947) MINT-61487

About this table

2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006468	protein amino acid phosphorylation	TAS	1945408
GO:0008285	negative regulation of cell proliferation	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for CSK

Sigma-Aldrich Small Molecules for CSK:

Inhibitor

Browse Tocris compounds for CSK
10/37 Novoseek chemical compound relationships for CSK gene (see all 37 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	87.99	432	8621646 (5), 17233630 (5), 9794236 (4), 10845713 (4) (see all 99)
phosphotyrosine	68.93	16	7683128 (2), 7544435 (2), 7524477 (1), 9618476 (1) (see all 6)
4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine	58.89	1	15451023 (1)
phosphatidylinositol	42.76	7	7524477 (1), 8626429 (1), 12837289 (1), 16530387 (1) (see all 7)
threonine	40.57	2	1379736 (1), 8813150 (1)
pd 98,059	39.46	4	18971559 (1), 16172428 (1), 17283870 (1), 14704150 (1)
tcdd	33.43	15	9707505 (3), 17223712 (2), 15674848 (2), 15674841 (1) (see all 7)
gdp(beta-s)	27.00	3	18971559 (1), 16172428 (1), 17283870 (1)
atp	26.61	12	7527038 (2), 9048573 (2), 8529658 (1), 9190882 (1) (see all 9)
sp 600125	25.14	1	16213648 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CSK)
		Millipore RNAi Products for the Analysis of CSK Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (CSK)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001127190

Sigma-Aldrich siRNA and siRNA Panels for CSK

Sigma-Aldrich shRNA Panels and shRNA for CSK

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001127190 NM_004383

REFSEQ mRNAs for CSK gene (2 alternative transcripts):

NM_001127190.1 NM_004383.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001127190 NM_004383

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001127190
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001127190
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001127190

Additional cDNA sequence:

AB451288.1 AB451420.1 AK127672.1 AK223626.1 AK290531.1 AK297694.1 AK298245.1 AK309344.1

AK310136.1 AK312669.1 AY007162.1 BC104847.1 BC104875.1 BC106073.1 CR541960.1 CR620625.1

X59932.1 X60114.1

12 DOTS entries:

DT.445561 DT.101983024 DT.100794281 DT.121045785 DT.121045769 DT.86998996 DT.100794276 DT.100794279

DT.95335504 DT.97795792 DT.99978627 DT.95335507

24/335 AceView cDNA sequences (see all 335 ):

BQ678773 BM559131 BU168116 BQ645407 BG684389 BQ053616 AL120509 BM700224

CD369793 BM709046 BU732506 AL048646 BM768847 CF264931 BU844454 CK430451

BU838081 BQ053738 AI675456 BM917940 BQ670890 AY007162 BG576865 CB109729

highest scoring ESTs for CSK:

X59932 AA210823 AA278252 AA279470 AA594500 AA609402 AA613912 AA613919 AA714748 AA789308

Unigene Cluster for CSK:

C-src tyrosine kinase

Hs.77793 [show with all ESTs]

Unigene Representative Sequence: NM_004383

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for CSK (see all 10 )

ExUns:	1	^	2a	·	2b	^	3	^	4	^	5	^	6a	·	6b	^	7a	·	7b	^	8	^	9a	·	9b	·	9c	^	10	^	11	^	12	^	13a	·	13b	^	14a	·	14b	·	14c	^	15	^	16a	·	16b	·	16c	·
SP1:															-								-								-								-
SP2:							-		-		-				-								-								-								-
SP3:			-				-		-		-				-								-								-								-
SP4:																															-								-
SP5:																																							-

ExUns:	16d	^	17a	·	17b	^	18a	·	18b
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for CSK

1 Ensembl transcript including schematic representation:

ENST00000220003

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CSK expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CSK

¹ / ² / ³

3 probe-sets matching CSK gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1768_s_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	X59932	1.00	1.00	1.00	1
202329_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_004383	0.60	1.00	0.82	1
202329_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AGGACACCGC

SOURCE GeneReport for Unigene cluster: Hs.77793
Expression variation in blood from EXPOLDB for CSK
UniProtKB/Swiss-Prot: CSK_HUMAN, P41240
Tissue specificity: Expressed in lung and macrophages

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CSK gene from 5/13 species (see all 13 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CSK¹	--	c-src tyrosine kinase	92.96(n) 98.67(a)	487649 XM_862019.1 XP_867112.1
chimpanzee (Pan troglodytes)	CSK¹	--	c-src tyrosine kinase	98.3(n) 98.44(a)	453745 XM_510671.2 XP_510671.2
cow (Bos taurus)	CSK¹	--	c-src tyrosine kinase	93.04(n) 98.67(a)	509246 NM_001075397.1 NP_001068865.1
rat (Rattus norvegicus)	Csk¹	--	c-src tyrosine kinase	90.22(n) 98.44(a)	315707 NM_001030039.1 NP_001025210.1
mouse (Mus musculus)	Csk^{1, 5}	9 (32.00 cM)⁵	c-src tyrosine kinase^{1, 5}	90.07(n)¹ 99.11(a)¹	12988¹ NM_007783.2¹ NP_031809.2¹ AK013057⁵ AK136876⁵ (see all 20)

About this table Species with no ortholog for CSK

ENSEMBL Gene Tree for CSK

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for CSK gene

MATK² SRMS² PTK6²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/186 NCBI SNPs in CSK are shown (see all 186 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 118)

AB	SNP ID	Valid	Chr 15 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
--	rs7085^1,2	A,C,F,H	72882536(+)	`GGAATC/TGTAAT`	2	--	ut3¹		22	MN NA NS EU EA WA	1952
	rs2071501^1,2	A,C,F,H	72882210(+)	`TTTTTT/GGAGAT`	2	--	ut3¹ trp³		12	NA EU EA WA NS	700
--	rs11553762^1,2	C,F	72881934(+)	`ATGGGC/TCTGTG`	2	--	ut3¹ ese³		5	NS	188
	rs11637900^1,2	C,H	72882752(+)	`GCTCAC/GCAGTT`	1	--	ng3¹		4	EU EA WA	420
--	rs4886624^1,2	C,F	72882206(-)	`CAAAAA/CAGGAA`	2	--	ut3¹ trp³		5	NS	190
	rs36039547^1,2	F	72881924(+)	`CGCCTG/AGGTCA`	2	--	ut3¹		5	NS	188
--	rs35182824^1,2	F	72861373(+)	`CCCCC-/CGCAGT`	1	--	ng5¹		5	NS	176
	rs34755093^1,2	F	72861257(+)	`GGAAAG/TCTGCG`	1	--	ng5¹		5	NS	178
	rs34697769^1,2	F	72882995(+)	`GTCTCA/GTGCCT`	1	--	ng3¹		5	NS	190
	rs34866753^1,2	F	72880962(+)	`GCTGGG/ACGGAG`	2	D/G	mis¹		5	NS	190

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HapMap Linkage Disequilibrium images for CSK (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 124095

10/25 Novoseek disease relationships for CSK gene (see all 25 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
osteopetrosis	37.38	1	7688650 (1)
colon cancer	36.38	7	14712234 (2), 11054667 (2), 15961079 (1), 10958949 (1) (see all 5)
breast cancer	34.78	19	11445575 (4), 11278729 (1), 12753909 (1), 12941830 (1) (see all 14)
colon carcinoma	32.48	2	7681838 (1), 11443610 (1)
cancer	25.74	14	14712234 (3), 7533218 (2), 15194078 (1), 16243715 (1) (see all 9)
colon adenocarcinoma	24.27	1	11054667 (1)
tumors	23.54	25	11084024 (4), 10974196 (2), 16716300 (2), 11445575 (2) (see all 16)
colon tumor	20.53	1	10974196 (1)
pancreatic carcinoma	15.42	2	10845713 (1)
breast carcinoma	13.92	5	11278729 (3), 11445575 (1), 15020686 (1)

About this table

Human Genome Epidemiology Navigator: CSK (7 documents)
Tumor Gene Database: CSK

(Possibly Related Articles in Doctor's Guide)
About This Section

New Findings Regarding CHK Gene in Breast Cancer Research

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/447 PubMed articles for CSK gene (see all 447 ):

Identification of csk tyrosine phosphorylation sites and a tyrosine residue important for kinase domain structure. (PubMed id 9148770)^{1, 3, 4} Joukov V....Bergman M. (1997)
The c-src tyrosine kinase (CSK) gene, a potential antioncogene, localizes to human chromosome region 15q23----q25. (PubMed id 1377109)^{1, 2, 3} Armstrong E....Alitalo K. (1992)
Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry. (PubMed id 17192257)^{3, 4} Wissing J.... Daub H. (2007)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
LIME: a new membrane raft-associated adaptor protein involved in CD4 and CD8 coreceptor signaling. (PubMed id 14610046)^{3, 4} Brdickova N....Horejsi V. (2003)
Structural and functional dissection of the cytoplasmic domain of the transmembrane adaptor protein SIT (SHP2-interacting transmembrane adaptor protein). (PubMed id 11433379)^{3, 4} Pfrepper K.-I.... Schraven B. (2001)
Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation. (PubMed id 10790433)^{3, 4} Brdicka T.... Schraven B. (2000)
The crystal structure of human CskSH3: structural diversity near the RT-Src and n-Src loop. (PubMed id 7511113)^{3, 4} Borchert T.V....Wierenga R.K. (1994)
Characterization of the human CSK locus. (PubMed id 7683131)^{3, 4} Braeuninger A.... Ruebsamen-Waigmann H. (1993)
Isolation and characterization of a human gene that encodes a new subclass of protein tyrosine kinases. (PubMed id 1371489)^{3, 4} Brauninger A.... Rubsamen-Waigmann H. (1992)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 1445	HGNC: 2444	AceView: CSK	Ensembl:ENSG00000103653	euGenes: HUgn1445
ECgene: CSK	H-InvDB: CSK

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for CSK	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/csk/

Licensable Technologies for CSK
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for CSK:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CSK-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CSK		Antibodies for CSK
	Explore super-pooled esiRNAs		Proteins for CSK
	Lentivirus-delivered shRNAs for CSK		Small molecules for CSK
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (CSK)
	Antibodies (CSK)
	Chimera RNAi (CSK)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for CSK

	Recombinant Proteins (CSK)
	Antibodies (CSK)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for CSK

	Drugs/Proteins for CSK
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for CSK

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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CSK Gene at Home site.
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CSK Gene

protein-coding GIFtS: 71

Aliases &
Descriptions
for CSK

Summaries
for CSK

Genomic Location
for CSK

Proteins
for CSK

Protein Domains/
Families
for CSK

Gene Function
for CSK

Pathways & Interactions
for CSK

Drugs & Compounds
for CSK

Transcripts
for CSK

Expression
for CSK

Orthologs
for CSK

Paralogs
for CSK

SNPs/Variants
for CSK

Disorders & Mutations
for CSK

Medical News
for CSK

Publications
for CSK

Search for CSK

Genome Databases showing CSK

Other Databases showing CSK

Specialized Databases showing CSK

Licensable Technologies
for CSK

Services
for CSK

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CSK Gene

protein-coding GIFtS: 71

Aliases & Descriptionsfor CSK

Summariesfor CSK

Genomic Locationfor CSK

Proteinsfor CSK

Protein Domains/Familiesfor CSK

Gene Functionfor CSK

Pathways & Interactionsfor CSK

Drugs & Compoundsfor CSK

Transcriptsfor CSK

Expression for CSK

Orthologsfor CSK

Paralogsfor CSK

SNPs/Variantsfor CSK

Disorders & Mutationsfor CSK

Medical Newsfor CSK

Publicationsfor CSK

Search for CSK

Genome Databases showing CSK

Other Databases showing CSK

Specialized Databases showing CSK

Licensable Technologiesfor CSK

Servicesfor CSK

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CSK

Summaries
for CSK

Genomic Location
for CSK

Proteins
for CSK

Protein Domains/
Families
for CSK

Gene Function
for CSK

Pathways & Interactions
for CSK

Drugs & Compounds
for CSK

Transcripts
for CSK

Expression
for CSK

Orthologs
for CSK

Paralogs
for CSK

SNPs/Variants
for CSK

Disorders & Mutations
for CSK

Medical News
for CSK

Publications
for CSK

Licensable Technologies
for CSK

Services
for CSK