Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CSH2 Gene

protein-coding   GIFtS: 56
GCID: GC17M061949

Chorionic Somatomammotropin Hormone 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chorionic Somatomammotropin Hormone 21 2     hCS-B2
Placental Lactogen1 2 3     Choriomammotropin3
Chorionic Somatomammotropin B1 2     Lactogen3
CSB2 5     PL3
CS-22     

External Ids:    HGNC: 24411   Entrez Gene: 14432   Ensembl: ENSG000002132187   OMIM: 1188205   UniProtKB: P012433   

Export aliases for CSH2 gene to outside databases

Previous GC identifers: GC17M061599 GC17M064375 GC17M062290 GC17M062423 GC17M062426 GC17M059303 GC17M057317


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CSH2 Gene:
The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones and plays an
important role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with
four other related genes in the same transcriptional orientation; an arrangement which is thought to have evolved
by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity,
they are expressed selectively in different tissues. Alternative splicing generates additional isoforms of each
of the five growth hormones. This particular family member is expressed mainly in the placenta and utilizes
multiple transcription initiation sites. Expression of the identical mature proteins for chorionic
somatomammotropin hormones 1 and 2 is upregulated during development, while the ratio of 1 to 2 increases by
term. Structural and expression differences provide avenues for developmental regulation and tissue specificity.
(provided by RefSeq, Jul 2008)

GeneCards Summary for CSH2 Gene: 
CSH2 (chorionic somatomammotropin hormone 2) is a protein-coding gene. Diseases associated with CSH2 include epithelioid trophoblastic tumor, and trophoblastic neoplasm, and among its related super-pathways are Prolactin Signaling Pathway and Class A/1 (Rhodopsin-like receptors). An important paralog of this gene is GH2.

UniProtKB/Swiss-Prot: CSH_HUMAN, P01243
Function: Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism.
Does not interact with GHR but only activates PRLR through zinc-induced dimerization




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CSH2 gene promoter:
         HFH-1   POU3F1   COMP1   CUTL1   Arnt   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for CSH2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CSH2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q24.2   Ensembl cytogenetic band:  17q23.3   HGNC cytogenetic band: 17q22-q24

CSH2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CSH2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M061949:  view genomic region     (about GC identifiers)

Start:
61,949,372 bp from pter      End:
61,951,126 bp from pter
Size:
1,755 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CSH_HUMAN, P01243 (See protein sequence)
Recommended Name: Chorionic somatomammotropin hormone precursor  
Size: 217 amino acids; 25020 Da
Subcellular location: Secreted
Miscellaneous: The sequence of CSH1 is shown
1 PDB 3D structure from and Proteopedia for CSH2:
1Z7C (3D)    
Secondary accessions: Q0VDB1 Q14407

Explore the universe of human proteins at neXtProt for CSH2: NX_P01243

Explore proteomics data for CSH2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P01243

  • CSH2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CSH2 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_066271.1  NP_072170.1  NP_072171.1  

    ENSEMBL proteins: 
     ENSP00000376623   ENSP00000338816   ENSP00000453452   ENSP00000308396  
    Reactome Protein details: P01243
    Human Recombinant Protein Products for CSH2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CSH2
    OriGene Protein Over-expression Lysate for CSH2
    OriGene MassSpec for CSH2 
    OriGene Custom Protein Services for CSH2
    GenScript Custom Purified and Recombinant Proteins Services for CSH2
    Novus Biologicals CSH2 Protein
    Novus Biologicals CSH2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CSH2 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----

    CSH2 for ontologies           About GeneDecksing



    CSH2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CSH2
    Browse R&D Systems for Antibodies
    OriGene Antibodies for CSH2
    OriGene Custom Antibody Services for CSH2
    GenScript Custom Superior Antibodies Services for CSH2
    Novus Biologicals CSH2 Antibodies
    Abcam antibodies for CSH2
    Cloud-Clone Corp. Antibodies for CSH2 
    ThermoFisher Antibody for CSH2
    LSBio Antibodies in human, mouse, rat for CSH2 

    Assay Products for CSH2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CSH2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CSH2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CSH2 
    Cloud-Clone Corp. CLIAs for CSH2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR018116 Somatotropin_CS
     IPR012351 4_helix_cytokine_core
     IPR009079 4_helix_cytokine-like_core
     IPR001400 Somatotropin

    Graphical View of Domain Structure for InterPro Entry P01243

    ProtoNet protein and cluster: P01243

    1 Blocks protein domain: IPB001400 Somatotropin hormone

    UniProtKB/Swiss-Prot: CSH_HUMAN, P01243
    Similarity: Belongs to the somatotropin/prolactin family


    CSH2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CSH_HUMAN, P01243
    Function: Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism.
    Does not interact with GHR but only activates PRLR through zinc-induced dimerization

         Genatlas biochemistry entry for CSH2:
    chorionic somatomammotropin hormone 2 (see GH@)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005179hormone activity ----
    GO:0046872metal ion binding ----
         
    CSH2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CSH2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CSH2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CSH2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CSH2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CSH2
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CSH2
    SwitchGear 3'UTR luciferase reporter plasmidCSH2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CSH2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CSH2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CSH2
    Sirion Biotech Customized adenovirus for overexpression of CSH2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CSH2 (see all 16)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): CSH2 (NM_022645)
    Sino Biological Human cDNA Clone for CSH2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CSH2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSH2
    Sirion Biotech Customized lentivirus for stable overexpression of CSH2 
                         Customized lentivirus expression plasmids for stable overexpression of CSH2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CSH2
    Search LifeMap BioReagents cell lines for CSH2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSH2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CSH2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Development Prolactin receptor signaling
    Development Prolactin receptor signaling0.39
    2Class A/1 (Rhodopsin-like receptors)
    Neuroactive ligand-receptor interaction0.37
    3PI3K-Akt signaling pathway
    PI3K-Akt signaling pathway
    4Jak-STAT signaling pathway
    Jak-STAT signaling pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for CSH2
        Development Prolactin receptor signaling


    1 GeneGo (Thomson Reuters) Pathway for CSH2
        Development Prolactin receptor signaling


    5/7        Reactome Pathways for CSH2 (see all 7)
        Cytokine Signaling in Immune system
    Signal Transduction
    Growth hormone receptor signaling
    Prolactin receptor signaling
    Signaling by ERBB4


    3         Kegg Pathways  (Kegg details for CSH2):
        Neuroactive ligand-receptor interaction
    PI3K-Akt signaling pathway
    Jak-STAT signaling pathway


    CSH2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CSH2

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/7 Interacting proteins for CSH2 (P012432, 3 ENSP000003766234) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD2Q157962, 3, ENSP000002621604MINT-60918 I2D: score=2 STRING: ENSP00000262160
    PTPN12Q052092, 3MINT-61776 I2D: score=2 
    SMAD4Q134852, 3, ENSP000003415514MINT-61946 I2D: score=2 STRING: ENSP00000341551
    SMAD9O151982, 3, ENSP000003691544MINT-62064 I2D: score=2 STRING: ENSP00000369154
    SMAD3P840223, ENSP000003329734I2D: score=2 STRING: ENSP00000332973
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction ----
    GO:0007565female pregnancy ----
    GO:0060397JAK-STAT cascade involved in growth hormone signaling pathway ----

    CSH2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CSH2 (CSH)

    Search CenterWatch for drugs/clinical trials and news about CSH2 / CSH

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CSH2 gene (3 alternative transcripts): 
    NM_020991.3  NM_022644.3  NM_022645.2  

    Unigene Cluster for CSH2:

    Chorionic somatomammotropin hormone 2
    Hs.654515  [show with all ESTs]
    Unigene Representative Sequence: CB992425
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000392886(uc002jch.3 uc002jcg.3) ENST00000336844(uc002jci.3)
    ENST00000560142 ENST00000559928 ENST00000558516 ENST00000345366
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CSH2
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CSH2
    SwitchGear 3'UTR luciferase reporter plasmidCSH2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CSH2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CSH2
    Clone
    Products:
         
    OriGene clones in human, mouse for CSH2 (see all 16)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): CSH2 (NM_022645)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CSH2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSH2
    Sirion Biotech Customized lentivirus for stable overexpression of CSH2 
                         Customized lentivirus expression plasmids for stable overexpression of CSH2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CSH2
    OriGene qSTAR qPCR primer pairs in human, mouse for CSH2
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat CSH2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CSH2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CSH2

    Additional mRNA sequence: 

    AB019574.1 BC022044.1 BC035965.1 BC111536.1 BC119748.2 V00573.1 

    24/132 DOTS entries (see all 132):

    DT.95278368  DT.92434084  DT.100715479  DT.100838861  DT.92061817  DT.91766654  DT.100715496  DT.100715602 
    DT.100715588  DT.100715551  DT.95092424  DT.100715566  DT.100715495  DT.100862539  DT.100715547  DT.100715507 
    DT.97868481  DT.87015311  DT.92455957  DT.100715518  DT.100862608  DT.100715567  DT.100715568  DT.91810789 

    24/442 AceView cDNA sequences (see all 442):

    CR616852 CR606994 CR590740 CR592879 CR601892 NM_020991 CR626395 CR618933 
    CR609245 CR594159 CR611038 CR599897 CR604195 CR593469 CR594864 CR613771 
    CR593623 CR595296 CR622470 CR606743 CR602672 CR608751 CR605508 CR611962 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CSH2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CSH2 Expression
    About this image


    See CSH2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CSH2

    SOURCE GeneReport for Unigene cluster: Hs.654515
        SABiosciences Custom PCR Arrays for CSH2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CSH2
    OriGene qSTAR qPCR primer pairs in human, mouse for CSH2
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat CSH2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CSH2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CSH2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSH2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CSH2 gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves GH16
    Somatotropin
    52(a)
    1 → many
    27(1616706-1620213)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    45(a)
    1 → many
    6(63428935-63436554)
    zebrafish
    (Danio rerio)
    Actinopterygii gh16
    smtla6
    (see all 3)
    somatolactin alpha
    (see all 3)
    34(a)
    20(a)
    (see all 3)
    1 ↔ many
    possible ortholog
    (see all 3)
    3(22540799-22545974)
    18(46620558-46629935)
            Species with no ortholog for CSH2

    ENSEMBL Gene Tree for CSH2 (if available)
    TreeFam Gene Tree for CSH2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CSH2 gene
    CSH11 2  GH22  GH12  CSHL12  
    4 SIMAP similar genes for CSH2 using alignment to 4 protein entries:     CSH_HUMAN (see all proteins):
    CSHL1    CSH1    GH1    GH2

    CSH2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/19 SNPs in CSH2 are shown (see all 19)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1469671711,2
    C--61950632(+) TGGACA/C/GGCACC 9 A syn11NA 4550
    rs1997839181,2
    C--61950910(+) CAGGGA/C/TCTGCC 3 -- int11EU 1117
    rs617640081,2
    C--61950932(-) ACAACG/ATGTCC 3 -- int13Minor allele frequency- A:0.01EU WA EA 148
    rs617640071,2
    C--61950943(-) TCCCTT/CTGGGC 3 -- int14Minor allele frequency- C:0.00EU WA EA 1441
    rs1491439351,2
    C,F--61950979(+) TTGCCG/ACTAGG 3 -- ut511Minor allele frequency- A:0.11EU 899
    rs3700072741,2
    ----61950668(+) AGCAGA/GGCAAA 6 A syn10--------
    rs3684682911,2
    ----61950958(+) AGGGGC/TGCTTA 3 -- int10--------
    rs357858871,2
    ----61952937(+) CTTTCC/TTTCCT 3 -- us2k10--------
    rs3694794111,2
    ----61950814(+) AGGAAC/TTTCAG 3 -- int10--------
    rs3750948351,2
    ----61952782(+) TCTTT-/CTT   
       TCTTT
    TCTTT
    3 -- us2k10--------

    HapMap Linkage Disequilibrium report for CSH2 (61949372 - 61951126 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for CSH2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2716099CNV Deletion23290073
    nsv436234CNV Deletion17901297
    esv2716098CNV Deletion23290073
    nsv833510CNV Loss17160897
    nsv510720CNV Loss20534489
    nsv833511CNV Loss17160897
    nsv517272CNV Gain+Loss19592680

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CSH2
    DNA2.0 Custom Variant and Variant Library Synthesis for CSH2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 118820    OMIM disorders: --

    12 diseases for CSH2:    About MalaCards
    epithelioid trophoblastic tumor    trophoblastic neoplasm    gestational trophoblastic neoplasm    placental insufficiency
    placental abruption    noonan syndrome    choriocarcinoma    gestational diabetes
    pre-eclampsia    eclampsia    diabetes mellitus    thyroiditis

    6 diseases from the University of Copenhagen DISEASES database for CSH2:
    Choriocarcinoma     Epithelioid trophoblastic tumor     Cockayne syndrome     Gestational trophoblastic neoplasm
    Placental insufficiency     Hypertension

    CSH2 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for CSH2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    choriocarcinoma 73 2 1708334 (1), 8472847 (1)

    Genetic Association Database (GAD): CSH2
    Human Genome Epidemiology (HuGE) Navigator: CSH2 (1 document)

    Export disorders for CSH2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CSH2 gene, integrated from 9 sources (see all 44):
    (articles sorted by number of sources associating them with CSH2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Analysis of a major human chorionic somatomammotropin gene. Evidence for two functional promoter elements. (PubMed id 6208192)1, 2, 3 Selby M.J.... Eberhardt N.L. (1984)
    2. Construction and analysis of recombinant DNA for human chorionic somatomammotropin. (PubMed id 593368)1, 2, 3 Shine J.... Goodman H.M. (1977)
    3. Late life metabolic syndrome, early growth, and common polymorphism in the growth hormone and placental lactogen gene cluster. (PubMed id 15531513)1, 4 Day I.N....Phillips D.I. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The human growth hormone locus: nucleotide sequence, biology, and evolution. (PubMed id 2744760)1, 2 Chen E.Y....Seeburg P.H. (1989)
    6. The human growth hormone gene locus: structure, evolution, and allelic variations. (PubMed id 3030680)1, 2 Hirt H.... Barta A. (1987)
    7. Two structurally different genes produce the same secreted human placental lactogen hormone. (PubMed id 6300056)1, 2 Barrera-Saldana H.A.... Saunders G.F. (1983)
    8. The human growth hormone gene family: nucleotide sequences show recent divergence and predict a new polypeptide hormone. (PubMed id 7169009)1, 2 Seeburg P.H. (1982)
    9. Identification of the interchain disulfide bonds of dimeric human placental lactogen. (PubMed id 438159)1, 2 Schneider A.B.... Sherwood L.M. (1979)
    10. Amino acid sequence of human chorionic somatomammotropin. (PubMed id 4712450)1, 2 Li C.H.... Chung D. (1973)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1443 HGNC: 2441 AceView: CSH1andGH2andCSH2 Ensembl:ENSG00000213218 euGenes: HUgn1443
    ECgene: CSH2 Kegg: 1443 H-InvDB: CSH2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CSH2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CSH2 gene:
    Search GeneIP for patents involving CSH2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of CSH2
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for CSH2   OriGene RNAi products in human, mouse, rat for CSH2  
     OriGene qPCR primer pairs and template standards for CSH2   OriGene Protein Over-expression Lysate for CSH2  
     OriGene MassSpec something-or-other for CSH2   OriGene clones in human, mouse for CSH2  
     OriGene qSTAR qPCR primer pairs in human, mouse for CSH2   OriGene Purified Protein for CSH2  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CSH2   OriGene Custom Protein Services for CSH2  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CSH2
     QIAGEN SeqTarget long-range PCR primers for resequencing CSH2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CSH2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CSH2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CSH2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CSH2
     GenScript Custom Purified and Recombinant Proteins Services for CSH2 GenScript cDNA clones with any tag delivered in your preferred vector for CSH2
     GenScript Custom Assay Services for CSH2 GenScript Custom Superior Antibodies Services for CSH2
     GenScript Custom overexpressing Cell Line Services for CSH2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CSH2 promoter
     Search Chromatin IP Primers for CSH2
     Search RT2 qPCR Primer Assays in human, mouse, rat CSH2
     Search GNC Networks for CSH2
     SABiosciences Custom PCR Arrays for CSH2
     Search Tocris compounds for CSH2 (CSH)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for CSH2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CSH2 antibodies
     CSH2 proteins
     CSH2 lysates
     Antibodies for CSH2
     See all of Abcam's Antibodies, Kits and Proteins for CSH2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for CSH2
     Antibodies for CSH2
     ELISAs for CSH2
     CLIAs for CSH2
     Search LifeMap BioReagents cell lines for CSH2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSH2
     SwitchGear 3'UTR luciferase reporter plasmids for CSH2
     Browse SwitchGear Promoter luciferase reporter plasmids for CSH2
     ThermoFisher Antibody for CSH2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSH2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CSH2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CSH2
    Customized:
     lentivirus for stable overexpression of CSH2
     lentivirus expression plasmids for stable overexpression of CSH2
     adenovirus for overexpression of CSH2
     LSBio Antibodies in human, mouse, rat for CSH2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CSH2 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4