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CSH1 Gene

protein-coding   GIFtS: 64
GCID: GC17M061972

Chorionic Somatomammotropin Hormone 1 (Placental Lactogen)

  See CSH1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chorionic Somatomammotropin Hormone 1 (Placental Lactogen)1 2     CSMT2
Placental Lactogen1 2 3     Chorionic Somatomammotropin Hormone2
PL2 3 5     Chorionic Somatomammotropin-12
choriomammotropin1 2     hCS-12
Chorionic Somatomammotropin A1 2     hCS-A2
CSA2 5     Choriomammotropin3
CS-12     Lactogen3

External Ids:    HGNC: 24401   Entrez Gene: 14422   Ensembl: ENSG000001364887   OMIM: 1502005   UniProtKB: P012433   

Export aliases for CSH1 gene to outside databases

Previous GC identifers: GC17U990017 GC17M064398 GC17M062291 GC17M062422 GC17M062445 GC17M059326 GC17M059307 GC17M057339


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CSH1 Gene:
The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones and plays an
important role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with
four other related genes in the same transcriptional orientation; an arrangement which is thought to have evolved
by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity,
they are expressed selectively in different tissues. Alternative splicing generates additional isoforms of each
of the five growth hormones, leading to further diversity and potential for specialization. This particular
family member is expressed mainly in the placenta and utilizes multiple transcription initiation sites.
Expression of the identical mature proteins for chorionic somatomammotropin hormones 1 and 2 is upregulated
during development, although the ratio of 1 to 2 increases by term. Mutations in this gene result in placental
lactogen deficiency and Silver-Russell syndrome. (provided by RefSeq, Jul 2008)

GeneCards Summary for CSH1 Gene:
CSH1 (chorionic somatomammotropin hormone 1 (placental lactogen)) is a protein-coding gene. Diseases associated with CSH1 include epithelioid trophoblastic tumor, and silver-russell syndrome. GO annotations related to this gene include hormone activity. An important paralog of this gene is GH2.

UniProtKB/Swiss-Prot: CSH_HUMAN, P01243
Function: Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism.
Does not interact with GHR but only activates PRLR through zinc-induced dimerization




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the CSH1 gene promoter:
         AML1a   POU3F1   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   GATA-1   Arnt   COMP1   HFH-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCSH1 promoter sequence
   Search Chromatin IP Primers for CSH1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CSH1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q24.2   Ensembl cytogenetic band:  17q23.3   HGNC cytogenetic band: 17q22-q24

CSH1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CSH1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M061972:  view genomic region     (about GC identifiers)

Start:
61,972,268 bp from pter      End:
61,974,021 bp from pter
Size:
1,754 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CSH_HUMAN, P01243 (See protein sequence)
Recommended Name: Chorionic somatomammotropin hormone precursor  
Size: 217 amino acids; 25020 Da
Miscellaneous: The sequence of CSH1 is shown
1 PDB 3D structure from and Proteopedia for CSH1:
1Z7C (3D)    
Secondary accessions: Q0VDB1 Q14407

Explore the universe of human proteins at neXtProt for CSH1: NX_P01243

Explore proteomics data for CSH1 at MOPED


See CSH1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001308.1  
ENSEMBL proteins: 
 ENSP00000316416   ENSP00000333268   ENSP00000402517  
Reactome Protein details: P01243

CSH1 Human Recombinant Protein Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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4 InterPro protein domains:
 IPR018116 Somatotropin_CS
 IPR012351 4_helix_cytokine_core
 IPR009079 4_helix_cytokine-like_core
 IPR001400 Somatotropin

Graphical View of Domain Structure for InterPro Entry P01243

ProtoNet protein and cluster: P01243

1 Blocks protein domain: IPB001400 Somatotropin hormone

UniProtKB/Swiss-Prot: CSH_HUMAN, P01243
Similarity: Belongs to the somatotropin/prolactin family


Find genes that share domains with CSH1           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: CSH_HUMAN, P01243
Function: Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism.
Does not interact with GHR but only activates PRLR through zinc-induced dimerization

     Genatlas biochemistry entry for CSH1:
chorionic somatomammotropin hormone 1 (see GH@)

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005179hormone activity IEA--
GO:0046872metal ion binding IEA--
     
Find genes that share ontologies with CSH1           About GenesLikeMe


Phenotypes:
     1 GenomeRNAi human phenotype for CSH1:
 Decreased homologous recombina 

Animal Models:
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Gene Editing
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Sino Biological Human cDNA Clone for CSH1
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSH1

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In Situ Assay
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
CSH_HUMAN, P01243: Secreted
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular5
cytoskeleton2
endoplasmic reticulum2
nucleus2
plasma membrane2
golgi apparatus1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--

Find genes that share ontologies with CSH1           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for CSH1 About   (see all 9)  
See pathways by source

SuperPathContained pathways About
1Nuclear signaling by ERBB4
Nuclear signaling by ERBB4
Prolactin receptor signaling0.00
2PI-3K cascade
Signaling by ERBB40.66
3Interferon Signaling
Cytokine Signaling in Immune system0.59
4Signaling by GPCR
Signal Transduction0.58
5Prolactin Signaling Pathway
Development Prolactin receptor signaling0.39


Find genes that share SuperPaths with CSH1           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 GeneGo (Thomson Reuters) Pathway for CSH1
    Development Prolactin receptor signaling


2 Reactome Pathways for CSH1
    Growth hormone receptor signaling
Prolactin receptor signaling


3 Kegg Pathways  (Kegg details for CSH1):
    Neuroactive ligand-receptor interaction
PI3K-Akt signaling pathway
Jak-STAT signaling pathway

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CSH1
Interactions:

    GeneGlobe Interaction Network for CSH1

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

Selected Interacting proteins for CSH1 (P012432, 3 ENSP000003332684) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
InteractantInteraction Details
GeneCardExternal ID(s)
SMAD2Q157962, 3, ENSP000002621604MINT-60918 I2D: score=2 STRING: ENSP00000262160
PTPN12Q052092, 3MINT-61776 I2D: score=2 
SMAD4Q134852, 3, ENSP000003415514MINT-61946 I2D: score=2 STRING: ENSP00000341551
SMAD9O151982, 3, ENSP000003691544MINT-62064 I2D: score=2 STRING: ENSP00000369154
POLR2AP249283I2D: score=2 
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Gene Ontology (GO): 3 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007165signal transduction NAS1378436
GO:0007565female pregnancy TAS1378436
GO:0060397JAK-STAT cascade involved in growth hormone signaling pathway TAS--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for CSH1 (CSH)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for CSH1 gene (3 alternative transcripts): 
NM_001317.5  NM_022640.3  NM_022641.3  

Unigene Cluster for CSH1:

Chorionic somatomammotropin hormone 1 (placental lactogen)
Hs.654390  [show with all ESTs]
Unigene Representative Sequence: BG622697
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000316193(uc002jcs.2) ENST00000329882 ENST00000558284 ENST00000558661
ENST00000453363
miRNA
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GenScript: all cDNA clones in your preferred vector: CSH1 (NM_001317)
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OriGene qPCR primer pairs and template standards for CSH1
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  QuantiFast Probe-based Assays in human, mouse, rat CSH1

Additional mRNA sequence: 

AK291587.1 BC002717.2 BC005921.1 BC020756.1 BC057768.1 BC062775.1 BT006926.1 J00118.1 
M25118.1 M35419.1 V00593.1 

Selected DOTS entries (see all 129):

DT.92434084  DT.100715479  DT.95278368  DT.92061817  DT.91766654  DT.100715496  DT.100715602  DT.100715588 
DT.100838861  DT.100862539  DT.95092424  DT.92434082  DT.100715584  DT.100715551  DT.100059909  DT.100715495 
DT.100715566  DT.97868481  DT.92455957  DT.100862608  DT.92434087  DT.100715568  DT.95222130  DT.91840785 

Selected AceView cDNA sequences (see all 442):

CR601066 CR608744 CR593413 CR599161 CR617268 CR594159 CR614158 CR594778 
CR613375 CR599408 CR601031 CR606466 CR619645 CR623229 CR603324 CR590382 
CR605778 CR594515 CR618992 CR603759 CR626176 CR606041 CR621181 CR619286 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for CSH1 (see all 8)    About this scheme

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1:                                                                                                                        
SP2:                                                                                                                        
SP3:                                                        -     -     -     -     -     -     -                           
SP4:                                                  -     -     -     -     -     -     -     -     -                     
SP5:                    -                                                                                                   


ECgene alternative splicing isoforms for CSH1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CSH1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GTGCAGTGCC
CSH1 Expression
About this image


CSH1 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 5) fully expand
 
 Placenta (Extraembryonic Tissues)    fully expand to see all 3 entries
         Villous Cytotrophoblast Cells Chorionic Villus
         placenta   
 
 Trophoblast (Extraembryonic Tissues)
         Trophoblast Cells Trophoblast
 
 Bone (Muscoskeletal System)
         TGFbeta3+BMP7-induced chondrocytes
 
 Cartilage (Muscoskeletal System)
         TGFbeta3+BMP7-induced chondrocytes
 
 Lung (Respiratory System)
CSH1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

CSH1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.654390
    Custom PCR Arrays for CSH1
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSH1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for CSH1 gene from Selected species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chicken
(Gallus gallus)
Aves GH16
Gallus gallus growth hormone (GH), mRNA.
54(a)
1 → many
27(1616706-1620213)
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
46(a)
1 → many
6(63428935-63436554)
zebrafish
(Danio rerio)
Actinopterygii gh16
growth hormone 1
34(a)
1 → many
3(22540799-22545974) ENSDARG00000038185
        Species with no ortholog for CSH1

ENSEMBL Gene Tree for CSH1 (if available)
TreeFam Gene Tree for CSH1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for CSH1 gene
CSH21 2  GH22  GH12  CSHL12  
4 SIMAP similar genes for CSH1 using alignment to 5 protein entries:     CSH_HUMAN (see all proteins):
CSHL1    GH2    CSH2    GH1

Find genes that share paralogs with CSH1           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for CSH1 (see all 154)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 17 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1416848801,2
--57339531(+) CTCATA/CTTAAA 1 -- ds50010--------
rs1503200701,2
--57339548(+) CCGAAC/TACAAG 1 -- ds50010--------
rs26658121,2
C,F,A--57339633(+) TTCTTT/CCCGCT 1 -- ds50011Minor allele frequency- C:0.27NA 120
rs1920402191,2
C--57339644(+) CCTGGA/GGGGCT 1 -- ds50010--------
rs1382887871,2
C--57339654(+) TAGGTG/TTGGTG 1 -- ds50010--------
rs1496077311,2
C--57339707(+) CTCTGA/GGATGA 1 -- ds50010--------
rs27273541,2
C,F,A,H--57339719(+) CAATGG/AGCTGT 1 -- ds50012Minor allele frequency- A:0.50NA 10
rs1409828141,2
C--57339723(+) GGGCTA/GTGACC 1 -- ds50010--------
rs1842203901,2
--57339748(+) ACTGAA/GCTGGT 1 -- ds50010--------
rs1874529561,2
--57339805(+) TTCTGC/GCCCAG 1 -- ds50010--------

HapMap Linkage Disequilibrium report for CSH1 (61972268 - 61974021 bp)

Structural Variations
     Database of Genomic Variants (DGV) 6 variations for CSH1:    About this table    
Variant IDTypeSubtypePubMed ID
esv2716099CNV Deletion23290073
esv2716100CNV Deletion23290073
nsv833510CNV Loss17160897
nsv510720CNV Loss20534489
nsv833511CNV Loss17160897
nsv517272CNV Gain+Loss19592680

Human Gene Mutation Database (HGMD): CSH1
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing CSH1
DNA2.0 Custom Variant and Variant Library Synthesis for CSH1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 150200    OMIM disorders: --

5 diseases for CSH1:    
About MalaCards
epithelioid trophoblastic tumor    silver-russell syndrome    trophoblastic neoplasm    gestational trophoblastic neoplasm
isolated growth hormone deficiency

5 diseases from the University of Copenhagen DISEASES database for CSH1:
Choriocarcinoma     Epithelioid trophoblastic tumor     Placental insufficiency     Gestational trophoblastic neoplasm
Hypertension

Find genes that share disorders with CSH1           About GenesLikeMe

1 Novoseek inferred disease relationship for CSH1 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
choriocarcinoma 75.4 5 1708334 (1), 12573257 (1), 15457851 (1), 8472847 (1)

Genatlas disease: CSH1
placental lactogen deficiency (CSH1 deficiency),with deletion encompassing CSH1,GHV,CSH2

Genetic Association Database (GAD): CSH1
Human Genome Epidemiology (HuGE) Navigator: CSH1 (4 documents)

Export disorders for CSH1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for CSH1 gene, integrated from 10 sources (see all 109):
(articles sorted by number of sources associating them with CSH1)
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  1. Analysis of a major human chorionic somatomammotropin gene. Evidence for two functional promoter elements. (PubMed id 6208192)1, 2, 3 Selby M.J.... Eberhardt N.L. (J. Biol. Chem. 1984)
  2. Do placental genes affect maternal breast cancer? Association between offspring's CGB5 and CSH1 gene variants and maternal breast cancer risk. (PubMed id 19047151)1, 4 Chen Y....Ahsan H. (Cancer Res. 2008)
  3. A study of association between common variation in the growth hormone-chorionic somatomammotropin hormone gene cluster and adult fasting insulin in a UK Caucasian population. (PubMed id 17125497)1, 4 Freathy R.M....Frayling T.M. (J Negat Results Biomed 2006)
  4. Crystal structure and site 1 binding energetics of human placental lactogen. (PubMed id 16546209)1, 2 Walsh S.T. and Kossiakoff A.A. (J. Mol. Biol. 2006)
  5. Late life metabolic syndrome, early growth, and common polymorphism in the growth hormone and placental lactogen gene cluster. (PubMed id 15531513)1, 4 Day I.N....Phillips D.I. (J. Clin. Endocrinol. Metab. 2004)
  6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  7. The human growth hormone locus: nucleotide sequence, biology, and evolution. (PubMed id 2744760)1, 2 Chen E.Y....Seeburg P.H. (Genomics 1989)
  8. The human growth hormone gene locus: structure, evolution, and allelic variations. (PubMed id 3030680)1, 2 Hirt H.... Barta A. (DNA 1987)
  9. Two structurally different genes produce the same secreted human placental lactogen hormone. (PubMed id 6300056)1, 2 Barrera-Saldana H.A.... Saunders G.F. (J. Biol. Chem. 1983)
  10. The human growth hormone gene family: nucleotide sequences show recent divergence and predict a new polypeptide hormone. (PubMed id 7169009)1, 2 Seeburg P.H. (DNA 1982)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1442 HGNC: 2440 AceView: CSH1andGH2andCSH2 Ensembl:ENSG00000136488 euGenes: HUgn1442
ECgene: CSH1 Kegg: 1442 H-InvDB: CSH1

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for CSH1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for CSH1 gene:
Search GeneIP for patents involving CSH1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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