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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CSH1 Gene

protein-coding   GIFtS: 67
GCID: GC17M061972

chorionic somatomammotropin hormone 1 (placental lactogen)
 Explore 24 diseases affiliated with
CSH1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CSH1    

Aliases
for CSH1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Chorionic Somatomammotropin Hormone 1 (Placental Lactogen)1 2     CS-12
PL1 2 3 5     Choriomammotropin3
CSA1 2 5     Chorionic Somatomammotropin A2
CSMT1 2     Chorionic Somatomammotropin Hormone2
HCS-A1     Choriomammotropin3
Placental Lactogen2 3     Lactogen3
FLJ754071     

External Ids:    HGNC: 24401   Entrez Gene: 14422   Ensembl: ENSG000001364887   OMIM: 1502005   UniProtKB: P012433   

Export aliases for CSH1 gene to outside databases

Previous GC identifers: GC17U990017 GC17M064398 GC17M062291 GC17M062422 GC17M062445 GC17M059326 GC17M059307 GC17M057339


Summaries
for CSH1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CSH1:
The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones and plays an important
role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with four other related
genes in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene
duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed
selectively in different tissues. Alternative splicing generates additional isoforms of each of the five growth
hormones, leading to further diversity and potential for specialization. This particular family member is expressed
mainly in the placenta and utilizes multiple transcription initiation sites. Expression of the identical mature
proteins for chorionic somatomammotropin hormones 1 and 2 is upregulated during development, although the ratio of 1
to 2 increases by term. Mutations in this gene result in placental lactogen deficiency and Silver-Russell syndrome.
(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CSH_HUMAN, P01243
Function: Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does
not interact with GHR but only activates PRLR through zinc-induced dimerization




Genomic Views
for CSH1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CSH1 gene promoter:
         AML1a   POU3F1   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   GATA-1   Arnt   COMP1   HFH-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CSH1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CSH1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CSH1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q24.2   Ensembl cytogenetic band:  17q23.3   HGNC cytogenetic band: 17q22-q24

CSH1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CSH1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M061972:  view genomic region     (about GC identifiers)

Start:
 61,972,273 bp from pter      End:
 61,974,021 bp from pter
Size:
 1,749 bases      Orientation:
 minus strand

Proteins
for CSH1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CSH_HUMAN, P01243 (See protein sequence)
Recommended Name: Chorionic somatomammotropin hormone precursor  
Size: 217 amino acids; 25020 Da
Subcellular location: Secreted
Miscellaneous: The sequence of CSH1 is shown
1 PDB 3D structure from and Proteopedia for CSH1:
1Z7C (3D)    
Secondary accessions: Q0VDB1 Q14407

Explore the universe of human proteins at neXtProt for CSH1: NX_P01243

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P01243

    • CSH1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001308.1  
    ENSEMBL proteins: 
     ENSP00000316416   ENSP00000453736   ENSP00000333268   ENSP00000402517  
    Reactome Protein details: P01243
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CSH1 (Placental Lactogen/CSH1)
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    OriGene Purified Protein: CSH1
    OriGene Protein Over-expression Lysate (see all 2): CSH1
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    Novus Biologicals CSH1 Proteins
    Novus Biologicals CSH1 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for CSH1
    Uscn Proteins for CSH1

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--


    CSH1 for ontologies           About GeneDecksing



    CSH1 Antibody Products: 
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    Assay Products for CSH1: 
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    Uscn ELISAs and CLIAs for CSH1

    Protein Domains /
    Families
    for CSH1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CSH1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR018116 Somatotropin_CS
     IPR012351 4_helix_cytokine_core
     IPR009079 4_helix_cytokine-like_core
     IPR001400 Somatotropin

    Graphical View of Domain Structure for InterPro Entry P01243

    ProtoNet protein and cluster: P01243

    1 Blocks protein family: IPB001400 Somatotropin hormone

    UniProtKB/Swiss-Prot: CSH_HUMAN, P01243
    Similarity: Belongs to the somatotropin/prolactin family


    Function
    for CSH1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CSH_HUMAN, P01243
    Function: Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does
    not interact with GHR but only activates PRLR through zinc-induced dimerization

         Genatlas biochemistry entry for CSH1:
    chorionic somatomammotropin hormone 1 (see GH@)

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    In Situ Assay
    Products:       
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005179hormone activity IEA--
    GO:0046872metal ion binding IEA--


    CSH1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for CSH1:
     Decreased homologous recombina 


    Pathways & Interactions
    for CSH1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1JAK2 phosphorylation
    		JAK2 phosphorylation1.00
    		PRLR is phosphorylated at Ser-3490.86
    		Tyrosine phosphorylation of PRLR0.86
    		PRLR activation0.86
    2FBXW7 WD mutants do not bind NICD1
    		Prolactin receptor is internalized0.25
    		Nuclear signaling by ERBB40.07
    		Prolactin receptor signaling0.18
    		Growth hormone receptor signaling0.00
    3Development_Prolactin receptor signaling
    		Development_Prolactin receptor signaling1.00
    		Development Prolactin receptor signaling1.00
    4Cytokine Signaling in Immune system
    		Cytokine Signaling in Immune system1.00
    5Immune System
    		Immune System1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for CSH1
        Development Prolactin receptor signaling


    1 GeneGo (Thomson Reuters) Pathway for CSH1
        Development Prolactin receptor signaling

    5/12        Reactome Pathways for CSH1 (see all 12)
        PRLR activation
    Cytokine Signaling in Immune system
    JAK2 phosphorylation
    PRLR is phosphorylated at Ser-349
    Prolactin receptor signaling


    2         Kegg Pathways  (Kegg details for CSH1):
        Neuroactive ligand-receptor interaction
    Jak-STAT signaling pathway


    CSH1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CSH1

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/9 Interacting proteins for CSH1 (P012432, 3 ENSP000003332684) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD2Q157962, 3, ENSP000002621604MINT-60918 I2D: score=2 STRING: ENSP00000262160
    PTPN12Q052092, 3MINT-61776 I2D: score=2 
    SMAD4Q134852, 3, ENSP000003415514MINT-61946 I2D: score=2 STRING: ENSP00000341551
    SMAD9O151982, 3, ENSP000003691544MINT-62064 I2D: score=2 STRING: ENSP00000369154
    POLR2AP249283I2D: score=2 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction NAS593368
    GO:0007565female pregnancy TAS1378436
    GO:0060397JAK-STAT cascade involved in growth hormone signaling pathway TAS--


    CSH1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CSH1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CSH1
    Search CenterWatch for drugs/clinical trials and news about CSH1 / CSH 

    Transcripts
    for CSH1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CSH1 gene (3 alternative transcripts): 
    NM_001317.5  NM_022640.3  NM_022641.3  

    Unigene Cluster for CSH1:

    Chorionic somatomammotropin hormone 1 (placental lactogen)
    Hs.654390  [show with all ESTs]
    Unigene Representative Sequence: BG622697
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000316193(uc002jcs.2) ENST00000560805 ENST00000329882 ENST00000558284
    ENST00000453363 ENST00000558661

    miRNA
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    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AK291587.1 BC002717.2 BC005921.1 BC020756.1 BC057768.1 BC062775.1 BT006926.1 J00118.1 
    M25118.1 M35419.1 V00593.1 

    24/121 DOTS entries (see all 121):

    DT.100715479  DT.92434084  DT.95278368  DT.100715496  DT.91766654  DT.92061817  DT.100715602  DT.100715588 
    DT.100838861  DT.100862539  DT.95092424  DT.92434082  DT.100715584  DT.100715551  DT.100715495  DT.100059909 
    DT.100715566  DT.97868481  DT.92455957  DT.100862608  DT.92434087  DT.100715568  DT.95222130  DT.91840785 

    24/442 AceView cDNA sequences (see all 442):

    CR623417 CR620014 CR626712 CR621891 AF006061 CR593959 CR610224 CR626031 
    CR619286 CR606598 CR609350 CR597430 CR606289 CR617369 CR615975 CR621181 
    CR605508 CR598579 CR597767 CR599528 CR602268 NM_022640 CR607763 CR611453 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CSH1 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
    SP1:                                                                                                                        
    SP2:                                                                                                                        
    SP3:                                                        -     -     -     -     -     -     -                           
    SP4:                                                  -     -     -     -     -     -     -     -     -                     
    SP5:                    -                                                                                                   


    ECgene alternative splicing isoforms for CSH1

    Expression
    for CSH1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CSH1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTGCAGTGCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CSH1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    PlacentaChorionic VillusSyncytiotrophoblast Multinuclear CellsExtraembryonic Tissues, Placenta
    PlacentaChorionic VillusVillous Cytotrophoblast CellsExtraembryonic Tissues, Placenta
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CSH1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CSH1

    SOURCE GeneReport for Unigene cluster: Hs.654390
        SABiosciences Custom PCR Arrays for CSH1
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    In Situ
    Assay Products:     
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    Orthologs
    for CSH1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for CSH1 gene from 3/6 species (see all 6)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SOMA_CHICK6
    		 Somatotropin
    		 54(a)
    		 1 → many
    		 27(1522166-1526523)
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 46(a)
    		 1 → many
    		 6(63429195-63436554)
    zebrafish
    (Danio rerio)    		 Actinopterygii gh16
    smtla6
    (see all 3)    		 somatolactin alpha
    (see all 3)    		 33(a)
    23(a)
    (see all 3)    		 1 ↔ many
    possible ortholog
    (see all 3)    		 3(22540799-22545974)
    18(46620558-46629935)


    ENSEMBL Gene Tree for CSH1 (if available)
    TreeFam Gene Tree for CSH1 (if available) 

    Paralogs
    for CSH1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CSH1 gene
    CSH21 2  GH22  PRL2  CSHL12  GH12  
    4 SIMAP similar genes for CSH1 using alignment to 6 protein entries:     CSH_HUMAN (see all proteins):
    CSHL1    CSH2    GH2    GH1

    CSH1 for paralogs           About GeneDecksing



    Genomic Variants
    for CSH1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/142 NCBI SNPs in CSH1 are shown (see all 142)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs10508991,2
    		C,--57339986(-) GCCCAC/TCAGCC 1 -- ut315Minor allele frequency- T:0.01EU WA EA NA 152
    rs115546781,2
    		C--57340032(-) GACCCC/TTCCCC 1 -- ut311Minor allele frequency- T:0.00NA 2
    rs32100931,2
    		--57340047(-) CGAGTA/GGCATC 1 -- ut313Minor allele frequency- G:0.04MN NA 188
    rs10508571,2
    		--57340050(-) GCCCGA/CGTAGC 1 -- ut31 ese34Minor allele frequency- C:0.28MN NA 372
    rs10508501,2
    		C,--57340073(-) GAGGGC/TAGCTG 2 G syn1 ese35Minor allele frequency- T:0.28MN EU WA EA NA 334
    rs10508401,2
    		--57340079(-) TCTGTG/AGAGGG 2 /V syn1 ese33Minor allele frequency- A:0.27MN NA 368
    rs560305291,2
    		C,F,--57340154(+) AGCCCG/ATAGTT 2 /Y syn11Minor allele frequency- A:0.00NA 4540
    rs617640021,2
    		C,F,,--57340357(-) AGGCCT/CTTCTC 1 -- int14Minor allele frequency- C:0.01EU WA EA NA 4666
    rs617640001,2
    		C,F,,--57340418(-) GCAGTA/CAGGCG 1 -- int15Minor allele frequency- C:0.00EU WA EA NA 4672
    rs617639991,2
    		C,F--57340426(-) TCTTTT/GTAGCA 1 -- int15Minor allele frequency- G:0.00EU WA EA NA 4664

    HapMap Linkage Disequilibrium report for CSH1 (61972273 - 61974021 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for CSH1
         1 CNV: 49909
    Human Gene Mutation Database (HGMD): CSH1

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    Disorders / Diseases
    for CSH1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CSH1 for disorders           About GeneDecksing

    OMIM gene information: 150200    OMIM disorders: --

    20/24 diseases for CSH1 (see all 24):    About MalaCards
    silver-russell syndrome    placental lactogen deficiency    isolated growth hormone deficiency, type ia    isolated growth hormone deficiency
    growth hormone deficiency    placenta accreta    gestational trophoblastic neoplasm    trophoblastic neoplasm
    epithelioid trophoblastic tumor    pre-eclampsia    placental abruption    placental insufficiency
    spontaneous abortion    short stature    cockayne syndrome    eclampsia
    choriocarcinoma    hepatitis b    breast carcinoma    breast cancer

    5 diseases from the University of Copenhagen DISEASES database for CSH1:
    Choriocarcinoma     Epithelioid trophoblastic tumor     Placental insufficiency     Gestational trophoblastic neoplasm
    Hypertension

    1 Novoseek disease relationship for CSH1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    choriocarcinoma 75.4 5 1708334 (1), 12573257 (1), 15457851 (1), 8472847 (1)

    Genatlas disease: CSH1
    placental lactogen deficiency (CSH1 deficiency),with deletion encompassing CSH1,GHV,CSH2

    Genetic Association Database (GAD): CSH1
    Human Genome Epidemiology (HuGE) Navigator: CSH1 (4 documents)

    Export disorders for CSH1 gene to outside databases

    Publications
    for CSH1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CSH1 gene, integrated from 9 sources (see all 105):
    (articles sorted by number of sources associating them with CSH1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Analysis of a major human chorionic somatomammotropin gene. Evidence for two functional promoter elements. (PubMed id 6208192)1, 2, 3 Selby M.J.... Eberhardt N.L. (1984)
    2. Crystal structure and site 1 binding energetics of human placental lactogen. (PubMed id 16546209)1, 2 Walsh S.T. and Kossiakoff A.A. (2006)
    3. Late life metabolic syndrome, early growth, and common polymorphism in the growth hormone and placental lactogen gene cluster. (PubMed id 15531513)1, 4 Day I.N....Phillips D.I. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The human growth hormone locus: nucleotide sequence, biology, and evolution. (PubMed id 2744760)1, 2 Chen E.Y....Seeburg P.H. (1989)
    6. The human growth hormone gene locus: structure, evolution, and allelic variations. (PubMed id 3030680)1, 2 Hirt H.... Barta A. (1987)
    7. Two structurally different genes produce the same secreted human placental lactogen hormone. (PubMed id 6300056)1, 2 Barrera-Saldana H.A.... Saunders G.F. (1983)
    8. The human growth hormone gene family: nucleotide sequences show recent divergence and predict a new polypeptide hormone. (PubMed id 7169009)1, 2 Seeburg P.H. (1982)
    9. Identification of the interchain disulfide bonds of dimeric human placental lactogen. (PubMed id 438159)1, 2 Schneider A.B.... Sherwood L.M. (1979)
    10. Construction and analysis of recombinant DNA for human chorionic somatomammotropin. (PubMed id 593368)1, 2 Shine J.... Goodman H.M. (1977)

    External Searches for CSH1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CSH1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1442 HGNC: 2440 AceView: CSH1andGH2andCSH2 Ensembl:ENSG00000136488 euGenes: HUgn1442
    ECgene: CSH1 Kegg: 1442 H-InvDB: CSH1

    Other Databases showing CSH1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CSH1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CSH1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CSH1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CSH1 gene:
    Search GeneIP for patents involving CSH1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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