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Aliases for CSH1 Gene

Aliases for CSH1 Gene

  • Chorionic Somatomammotropin Hormone 1 (Placental Lactogen) 2 3
  • Placental Lactogen 2 3 4
  • Choriomammotropin 2 3 4
  • PL 3 4 6
  • Chorionic Somatomammotropin A 2 3
  • CSA 3 6
  • Chorionic Somatomammotropin Hormone 1 3
  • Chorionic Somatomammotropin-1 3
  • Lactogen 4
  • HCS-1 3
  • HCS-A 3
  • CS-1 3
  • CSMT 3

External Ids for CSH1 Gene

Previous GeneCards Identifiers for CSH1 Gene

  • GC17U990017
  • GC17M064398
  • GC17M062291
  • GC17M062422
  • GC17M062445
  • GC17M059326
  • GC17M059307
  • GC17M061972
  • GC17M057339

Summaries for CSH1 Gene

Entrez Gene Summary for CSH1 Gene

  • The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones and plays an important role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with four other related genes in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed mainly in the placenta and utilizes multiple transcription initiation sites. Expression of the identical mature proteins for chorionic somatomammotropin hormones 1 and 2 is upregulated during development, although the ratio of 1 to 2 increases by term. Mutations in this gene result in placental lactogen deficiency and Silver-Russell syndrome. [provided by RefSeq, Jul 2008]

GeneCards Summary for CSH1 Gene

CSH1 (Chorionic Somatomammotropin Hormone 1 (Placental Lactogen)) is a Protein Coding gene. Diseases associated with CSH1 include epithelioid trophoblastic tumor and silver-russell syndrome. Among its related pathways are PI3K-Akt signaling pathway and PI-3K cascade. GO annotations related to this gene include hormone activity. An important paralog of this gene is CSHL1.

UniProtKB/Swiss-Prot for CSH1 Gene

  • Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSH1 Gene

Genomics for CSH1 Gene

Regulatory Elements for CSH1 Gene

Genomic Location for CSH1 Gene

Start:
63,894,908 bp from pter
End:
63,896,661 bp from pter
Size:
1,754 bases
Orientation:
Minus strand

Genomic View for CSH1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CSH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSH1 Gene

Proteins for CSH1 Gene

  • Protein details for CSH1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DML2-CSH1_HUMAN
    Recommended name:
    Chorionic somatomammotropin hormone 1
    Protein Accession:
    P0DML2
    Secondary Accessions:
    • P01243
    • Q0VDB1
    • Q14407

    Protein attributes for CSH1 Gene

    Size:
    217 amino acids
    Molecular mass:
    25020 Da
    Quaternary structure:
    • Can be found in a monomeric as well as dimeric form.
    Miscellaneous:
    • CSH1 sequence only differs from CSH2 sequence in 1 aa

    Three dimensional structures from OCA and Proteopedia for CSH1 Gene

neXtProt entry for CSH1 Gene

Proteomics data for CSH1 Gene at MOPED

Post-translational modifications for CSH1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CSH1 Gene

Antibody Products

  • R&D Systems Antibodies for CSH1 (Placental Lactogen/CSH1)

No data available for DME Specific Peptides for CSH1 Gene

Domains for CSH1 Gene

Protein Domains for CSH1 Gene

Graphical View of Domain Structure for InterPro Entry

P0DML2

UniProtKB/Swiss-Prot:

CSH1_HUMAN :
  • P0DML2
Family:
  • Belongs to the somatotropin/prolactin family.
genes like me logo Genes that share domains with CSH1: view

No data available for Gene Families for CSH1 Gene

Function for CSH1 Gene

Molecular function for CSH1 Gene

GENATLAS Biochemistry: chorionic somatomammotropin hormone 1 (see GH@)
UniProtKB/Swiss-Prot Function: Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization.

Gene Ontology (GO) - Molecular Function for CSH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CSH1: view

Phenotypes for CSH1 Gene

GenomeRNAi human phenotypes for CSH1:
genes like me logo Genes that share phenotypes with CSH1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CSH1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CSH1 Gene

Localization for CSH1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSH1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CSH1 Gene COMPARTMENTS Subcellular localization image for CSH1 gene
Compartment Confidence
extracellular 5
cytoskeleton 2
endoplasmic reticulum 2
nucleus 2
plasma membrane 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CSH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with CSH1: view

Pathways for CSH1 Gene

genes like me logo Genes that share pathways with CSH1: view

Interacting Proteins for CSH1 Gene

Gene Ontology (GO) - Biological Process for CSH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway TAS --
genes like me logo Genes that share ontologies with CSH1: view

Transcripts for CSH1 Gene

Unigene Clusters for CSH1 Gene

Chorionic somatomammotropin hormone 1 (placental lactogen):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CSH1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CSH1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1:
SP2:
SP3: - - - - - - -
SP4: - - - - - - - - -
SP5: -
SP6: -
SP7:
SP8:

Relevant External Links for CSH1 Gene

GeneLoc Exon Structure for
CSH1
ECgene alternative splicing isoforms for
CSH1

Expression for CSH1 Gene

mRNA expression in normal human tissues for CSH1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CSH1 Gene

This gene is overexpressed in Pituitary (30.3) and Adipose - Subcutaneous (17.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CSH1 Gene

SOURCE GeneReport for Unigene cluster for CSH1 Gene Hs.654390

genes like me logo Genes that share expressions with CSH1: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CSH1 Gene

Orthologs for CSH1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CSH1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CSHL1 36
  • 99 (a)
ManyToMany
CSHL1 36
  • 99 (a)
ManyToMany
PL-D 35
  • 98.31 (n)
  • 97.7 (a)
cow
(Bos Taurus)
Mammalia GH1 36
  • 62 (a)
OneToMany
dog
(Canis familiaris)
Mammalia GH1 36
  • 62 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Gh 36
  • 60 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia GH1 36
  • 57 (a)
OneToMany
chicken
(Gallus gallus)
Aves GH1 36
  • 54 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 46 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii gh1 36
  • 34 (a)
OneToMany
Species with no ortholog for CSH1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CSH1 Gene

ENSEMBL:
Gene Tree for CSH1 (if available)
TreeFam:
Gene Tree for CSH1 (if available)

Paralogs for CSH1 Gene

Paralogs for CSH1 Gene

Selected SIMAP similar genes for CSH1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CSH1: view

Variants for CSH1 Gene

Sequence variations from dbSNP and Humsavar for CSH1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1050840 -- 63,895,043(-) TCTGT(A/G)GAGGG synonymous-codon, reference
rs1050850 -- 63,895,037(-) GAGGG(C/T)AGCTG reference, synonymous-codon
rs1050857 -- 63,895,014(-) GCCCG(A/C)GTAGC utr-variant-3-prime
rs1050899 -- 63,894,950(-) GCCCA(C/T)CAGCC utr-variant-3-prime
rs2009894 -- 63,898,392(-) ctcta(C/T)ttaaa upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CSH1 Gene

Variant ID Type Subtype PubMed ID
nsv833510 CNV Loss 17160897
nsv510720 CNV Loss 20534489
nsv517272 CNV Gain+Loss 19592680
nsv833511 CNV Loss 17160897
esv2716099 CNV Deletion 23290073
esv2716100 CNV Deletion 23290073

Relevant External Links for CSH1 Gene

HapMap Linkage Disequilibrium report
CSH1
Human Gene Mutation Database (HGMD)
CSH1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSH1 Gene

Disorders for CSH1 Gene

(1) Novoseek inferred disease relationships for CSH1 Gene

Disease -log(P) Hits PubMed IDs
choriocarcinoma 75.4 4

Genatlas disease for CSH1 Gene

placental lactogen deficiency (CSH1 deficiency),with deletion encompassing CSH1,GHV,CSH2

Relevant External Links for CSH1

Genetic Association Database (GAD)
CSH1
Human Genome Epidemiology (HuGE) Navigator
CSH1
genes like me logo Genes that share disorders with CSH1: view

No data available for UniProtKB/Swiss-Prot for CSH1 Gene

Publications for CSH1 Gene

  1. Analysis of a major human chorionic somatomammotropin gene. Evidence for two functional promoter elements. (PMID: 6208192) Selby M.J. … Eberhardt N.L. (J. Biol. Chem. 1984) 2 3 4
  2. Amino-acid sequence of human placental lactogen. (PMID: 5286363) Sherwood L.M. … Lanner M. (Nature New Biol. 1971) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Late life metabolic syndrome, early growth, and common polymorphism in the growth hormone and placental lactogen gene cluster. (PMID: 15531513) Day I.N. … Phillips D.I. (J. Clin. Endocrinol. Metab. 2004) 3 48
  5. The human growth hormone locus: nucleotide sequence, biology, and evolution. (PMID: 2744760) Chen E.Y. … Seeburg P.H. (Genomics 1989) 3 4

Products for CSH1 Gene

Sources for CSH1 Gene

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