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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CSH1 Gene

protein-coding   GIFtS: 66
GCID: GC17M061972

Chorionic Somatomammotropin Hormone 1 (Placental Lactogen)

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chorionic Somatomammotropin Hormone 1 (Placental Lactogen)1 2     CS-12
Placental Lactogen1 2 3     CSMT2
PL2 3 5     Chorionic Somatomammotropin Hormone2
choriomammotropin1 2     hCS-A2
Chorionic Somatomammotropin A1 2     Choriomammotropin3
CSA2 5     Lactogen3

External Ids:    HGNC: 24401   Entrez Gene: 14422   Ensembl: ENSG000001364887   OMIM: 1502005   UniProtKB: P012433   

Export aliases for CSH1 gene to outside databases

Previous GC identifers: GC17U990017 GC17M064398 GC17M062291 GC17M062422 GC17M062445 GC17M059326 GC17M059307 GC17M057339


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CSH1 Gene:
The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones and plays an
important role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with
four other related genes in the same transcriptional orientation; an arrangement which is thought to have evolved
by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity,
they are expressed selectively in different tissues. Alternative splicing generates additional isoforms of each
of the five growth hormones, leading to further diversity and potential for specialization. This particular
family member is expressed mainly in the placenta and utilizes multiple transcription initiation sites.
Expression of the identical mature proteins for chorionic somatomammotropin hormones 1 and 2 is upregulated
during development, although the ratio of 1 to 2 increases by term. Mutations in this gene result in placental
lactogen deficiency and Silver-Russell syndrome. (provided by RefSeq, Jul 2008)

GeneCards Summary for CSH1 Gene: 
CSH1 (chorionic somatomammotropin hormone 1 (placental lactogen)) is a protein-coding gene. Diseases associated with CSH1 include trophoblastic neoplasm, and epithelioid trophoblastic tumor, and among its related super-pathways are Prolactin receptor signaling and PIP3 activates AKT signaling. GO annotations related to this gene include hormone activity and metal ion binding. An important paralog of this gene is GH2.

UniProtKB/Swiss-Prot: CSH_HUMAN, P01243
Function: Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism.
Does not interact with GHR but only activates PRLR through zinc-induced dimerization




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CSH1 gene promoter:
         AML1a   POU3F1   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   GATA-1   Arnt   COMP1   HFH-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCSH1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CSH1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CSH1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q24.2   Ensembl cytogenetic band:  17q23.3   HGNC cytogenetic band: 17q22-q24

CSH1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CSH1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M061972:  view genomic region     (about GC identifiers)

Start:
61,972,268 bp from pter      End:
61,974,021 bp from pter
Size:
1,754 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CSH_HUMAN, P01243 (See protein sequence)
Recommended Name: Chorionic somatomammotropin hormone precursor  
Size: 217 amino acids; 25020 Da
Subcellular location: Secreted
Miscellaneous: The sequence of CSH1 is shown
1 PDB 3D structure from and Proteopedia for CSH1:
1Z7C (3D)    
Secondary accessions: Q0VDB1 Q14407

Explore the universe of human proteins at neXtProt for CSH1: NX_P01243

Explore proteomics data for CSH1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P01243

  • CSH1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CSH1 Protein Expression
    REFSEQ proteins: NP_001308.1  
    ENSEMBL proteins: 
     ENSP00000316416   ENSP00000333268   ENSP00000402517  
    Reactome Protein details: P01243
    Human Recombinant Protein Products for CSH1: 
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    Novus Biologicals CSH1 Proteins
    Novus Biologicals CSH1 Lysates
    Sino Biological Recombinant Protein for CSH1
    Sino Biological Cell Lysate for CSH1 
    ProSpec Recombinant Protein for CSH1
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--

    CSH1 for ontologies           About GeneDecksing



    CSH1 Antibody Products: 
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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR018116 Somatotropin_CS
     IPR012351 4_helix_cytokine_core
     IPR009079 4_helix_cytokine-like_core
     IPR001400 Somatotropin

    Graphical View of Domain Structure for InterPro Entry P01243

    ProtoNet protein and cluster: P01243

    1 Blocks protein domain: IPB001400 Somatotropin hormone

    UniProtKB/Swiss-Prot: CSH_HUMAN, P01243
    Similarity: Belongs to the somatotropin/prolactin family


    CSH1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CSH_HUMAN, P01243
    Function: Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism.
    Does not interact with GHR but only activates PRLR through zinc-induced dimerization

         Genatlas biochemistry entry for CSH1:
    chorionic somatomammotropin hormone 1 (see GH@)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005179hormone activity IEA--
    GO:0046872metal ion binding IEA--
         
    CSH1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CSH1:
     Decreased homologous recombina 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CSH1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CSH1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CSH1 
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSH1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CSH1 About   (see all 9)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Prolactin receptor signaling
    Prolactin receptor signaling0.38
    Growth hormone receptor signaling0.31
    Nuclear signaling by ERBB40.38
    2PIP3 activates AKT signaling
    Signaling by ERBB40.67
    3Interferon Signaling
    Cytokine Signaling in Immune system0.61
    4Immune System
    Immune System0.56
    5Signaling by GPCR
    Signal Transduction0.55

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for CSH1
        Development Prolactin receptor signaling


    1 GeneGo (Thomson Reuters) Pathway for CSH1
        Development Prolactin receptor signaling


    5/7        Reactome Pathways for CSH1 (see all 7)
        Cytokine Signaling in Immune system
    Signal Transduction
    Growth hormone receptor signaling
    Prolactin receptor signaling
    Signaling by ERBB4


    3         Kegg Pathways  (Kegg details for CSH1):
        Neuroactive ligand-receptor interaction
    PI3K-Akt signaling pathway
    Jak-STAT signaling pathway


    CSH1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CSH1

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/9 Interacting proteins for CSH1 (P012432, 3 ENSP000003332684) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD2Q157962, 3, ENSP000002621604MINT-60918 I2D: score=2 STRING: ENSP00000262160
    PTPN12Q052092, 3MINT-61776 I2D: score=2 
    SMAD4Q134852, 3, ENSP000003415514MINT-61946 I2D: score=2 STRING: ENSP00000341551
    SMAD9O151982, 3, ENSP000003691544MINT-62064 I2D: score=2 STRING: ENSP00000369154
    POLR2AP249283I2D: score=2 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction NAS1378436
    GO:0007565female pregnancy TAS1378436
    GO:0060397JAK-STAT cascade involved in growth hormone signaling pathway TAS--

    CSH1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CSH1 (CSH)

    Search CenterWatch for drugs/clinical trials and news about CSH1 / CSH

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CSH1 gene (3 alternative transcripts): 
    NM_001317.5  NM_022640.3  NM_022641.3  

    Unigene Cluster for CSH1:

    Chorionic somatomammotropin hormone 1 (placental lactogen)
    Hs.654390  [show with all ESTs]
    Unigene Representative Sequence: BG622697
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000316193(uc002jcs.2) ENST00000329882 ENST00000558284 ENST00000558661
    ENST00000453363
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CSH1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CSH1

    Additional mRNA sequence: 

    AK291587.1 BC002717.2 BC005921.1 BC020756.1 BC057768.1 BC062775.1 BT006926.1 J00118.1 
    M25118.1 M35419.1 V00593.1 

    24/129 DOTS entries (see all 129):

    DT.92434084  DT.100715479  DT.95278368  DT.92061817  DT.91766654  DT.100715496  DT.100715602  DT.100715588 
    DT.100838861  DT.100862539  DT.95092424  DT.92434082  DT.100715584  DT.100715551  DT.100059909  DT.100715495 
    DT.100715566  DT.97868481  DT.92455957  DT.100862608  DT.92434087  DT.100715568  DT.95222130  DT.91840785 

    24/442 AceView cDNA sequences (see all 442):

    CR613729 CR599161 CR590494 CR615975 CR596602 CR620157 CR605300 CR601066 
    CR623276 CR602888 CR597646 CR600410 CR591160 CR591525 CR612322 CR625374 
    CR626011 CR610446 CR623287 CR621891 CR605365 CR611694 CR624074 CR607531 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CSH1 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
    SP1:                                                                                                                        
    SP2:                                                                                                                        
    SP3:                                                        -     -     -     -     -     -     -                           
    SP4:                                                  -     -     -     -     -     -     -     -     -                     
    SP5:                    -                                                                                                   


    ECgene alternative splicing isoforms for CSH1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CSH1 expression in normal human tissues (normalized intensities)      CSH1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGCAGTGCC
    CSH1 Expression
    About this image


    CSH1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 4 entries
             Villous Cytotrophoblast Cells Chorionic Villus
             placenta ; trophoblastic cells   
             placenta   
     
     Bone (Muscoskeletal System)
             TGFbeta3+BMP7-induced chondrocytes
     
     Cartilage (Muscoskeletal System)
             TGFbeta3+BMP7-induced chondrocytes
     
     Lung (Respiratory System)

     -- (Endocrine System)
             pituitary gland   

    See CSH1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CSH1

    SOURCE GeneReport for Unigene cluster: Hs.654390
        SABiosciences Custom PCR Arrays for CSH1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSH1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CSH1 gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves GH16
    Somatotropin
    52(a)
    1 → many
    27(1616706-1620213)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    46(a)
    1 → many
    6(63428935-63436554)
    zebrafish
    (Danio rerio)
    Actinopterygii gh16
    smtla6
    (see all 3)
    somatolactin alpha
    (see all 3)
    33(a)
    20(a)
    (see all 3)
    1 ↔ many
    possible ortholog
    (see all 3)
    3(22540799-22545974)
    18(46620558-46629935)
            Species with no ortholog for CSH1

    ENSEMBL Gene Tree for CSH1 (if available)
    TreeFam Gene Tree for CSH1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CSH1 gene
    CSH21 2  GH22  GH12  CSHL12  
    4 SIMAP similar genes for CSH1 using alignment to 5 protein entries:     CSH_HUMAN (see all proteins):
    CSHL1    GH2    CSH2    GH1

    CSH1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/154 SNPs in CSH1 are shown (see all 154)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0071664
    ----see VAR_0071662 P A mis40--------
    rs1416848801,2
    --57339531(+) CTCATA/CTTAAA 1 -- ds50010--------
    rs1503200701,2
    --57339548(+) CCGAAC/TACAAG 1 -- ds50010--------
    rs26658121,2
    C,F,A--57339633(+) TTCTTT/CCCGCT 1 -- ds50011Minor allele frequency- C:0.27NA 120
    rs1920402191,2
    C--57339644(+) CCTGGA/GGGGCT 1 -- ds50010--------
    rs1382887871,2
    C--57339654(+) TAGGTG/TTGGTG 1 -- ds50010--------
    rs1496077311,2
    C--57339707(+) CTCTGA/GGATGA 1 -- ds50010--------
    rs27273541,2
    C,F,A,H--57339719(+) CAATGG/AGCTGT 1 -- ds50012Minor allele frequency- A:0.50NA 10
    rs1409828141,2
    C--57339723(+) GGGCTA/GTGACC 1 -- ds50010--------
    rs1842203901,2
    --57339748(+) ACTGAA/GCTGGT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for CSH1 (61972268 - 61974021 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for CSH1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2716099CNV Deletion23290073
    esv2716100CNV Deletion23290073
    nsv833510CNV Loss17160897
    nsv510720CNV Loss20534489
    nsv833511CNV Loss17160897
    nsv517272CNV Gain+Loss19592680


    Human Gene Mutation Database (HGMD): CSH1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CSH1
    DNA2.0 Custom Variant and Variant Library Synthesis for CSH1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 150200    OMIM disorders: --

    20 diseases for CSH1:    About MalaCards
    trophoblastic neoplasm    epithelioid trophoblastic tumor    placenta accreta    silver-russell syndrome
    isolated growth hormone deficiency    gestational trophoblastic neoplasm    placental insufficiency    growth hormone deficiency
    placental abruption    choriocarcinoma    short stature    eclampsia
    pre-eclampsia    gestational diabetes    hepatitis b    diabetes mellitus
    thyroiditis    hepatitis    pancreatitis    breast cancer

    5 diseases from the University of Copenhagen DISEASES database for CSH1:
    Choriocarcinoma     Epithelioid trophoblastic tumor     Placental insufficiency     Gestational trophoblastic neoplasm
    Hypertension

    CSH1 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for CSH1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    choriocarcinoma 75.4 5 1708334 (1), 12573257 (1), 15457851 (1), 8472847 (1)

    Genatlas disease: CSH1
    placental lactogen deficiency (CSH1 deficiency),with deletion encompassing CSH1,GHV,CSH2

    Genetic Association Database (GAD): CSH1
    Human Genome Epidemiology (HuGE) Navigator: CSH1 (4 documents)

    Export disorders for CSH1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CSH1 gene, integrated from 9 sources (see all 107):
    (articles sorted by number of sources associating them with CSH1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Analysis of a major human chorionic somatomammotropin gene. Evidence for two functional promoter elements. (PubMed id 6208192)1, 2, 3 Selby M.J.... Eberhardt N.L. (1984)
    2. Do placental genes affect maternal breast cancer? Association between offspring's CGB5 and CSH1 gene variants and maternal breast cancer risk. (PubMed id 19047151)1, 4 Chen Y....Ahsan H. (2008)
    3. A study of association between common variation in the growth hormone-chorionic somatomammotropin hormone gene cluster and adult fasting insulin in a UK Caucasian population. (PubMed id 17125497)1, 4 Freathy R.M....Frayling T.M. (2006)
    4. Crystal structure and site 1 binding energetics of human placental lactogen. (PubMed id 16546209)1, 2 Walsh S.T. and Kossiakoff A.A. (2006)
    5. Late life metabolic syndrome, early growth, and common polymorphism in the growth hormone and placental lactogen gene cluster. (PubMed id 15531513)1, 4 Day I.N....Phillips D.I. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. The human growth hormone locus: nucleotide sequence, biology, and evolution. (PubMed id 2744760)1, 2 Chen E.Y....Seeburg P.H. (1989)
    8. The human growth hormone gene locus: structure, evolution, and allelic variations. (PubMed id 3030680)1, 2 Hirt H.... Barta A. (1987)
    9. Two structurally different genes produce the same secreted human placental lactogen hormone. (PubMed id 6300056)1, 2 Barrera-Saldana H.A.... Saunders G.F. (1983)
    10. The human growth hormone gene family: nucleotide sequences show recent divergence and predict a new polypeptide hormone. (PubMed id 7169009)1, 2 Seeburg P.H. (1982)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1442 HGNC: 2440 AceView: CSH1andGH2andCSH2 Ensembl:ENSG00000136488 euGenes: HUgn1442
    ECgene: CSH1 Kegg: 1442 H-InvDB: CSH1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CSH1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CSH1 gene:
    Search GeneIP for patents involving CSH1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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