Aliases for CSH1 Gene
External Ids for CSH1 Gene
Previous GeneCards Identifiers for CSH1 Gene
The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones and plays an important role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with four other related genes in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed mainly in the placenta and utilizes multiple transcription initiation sites. Expression of the identical mature proteins for chorionic somatomammotropin hormones 1 and 2 is upregulated during development, although the ratio of 1 to 2 increases by term. Mutations in this gene result in placental lactogen deficiency and Silver-Russell syndrome. [provided by RefSeq, Jul 2008]
GeneCards Summary for CSH1 Gene
CSH1 (Chorionic Somatomammotropin Hormone 1) is a Protein Coding gene. Diseases associated with CSH1 include Choriocarcinoma and Silver-Russell Syndrome. Among its related pathways are Jak-STAT signaling pathway and Immune System. GO annotations related to this gene include hormone activity. An important paralog of this gene is CSHL1.
UniProtKB/Swiss-Prot for CSH1 Gene
Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization.