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Aliases for CSGALNACT2 Gene

Aliases for CSGALNACT2 Gene

  • Chondroitin Sulfate N-Acetylgalactosaminyltransferase 2 2 3
  • Chondroitin Beta1,4 N-Acetylgalactosaminyltransferase 2 2 3
  • GALNACT-2 3 4
  • GALNACT2 3 4
  • CHGN2 3 4
  • Chondroitin Beta-1,4-N-Acetylgalactosaminyltransferase 2 4
  • Beta 4 GalNAcT-2 3
  • Beta4GalNAcT-2 4
  • EC 2.4.1.174 4
  • PRO0082 3

External Ids for CSGALNACT2 Gene

Previous GeneCards Identifiers for CSGALNACT2 Gene

  • GC10P042954
  • GC10P043633
  • GC10P040176

Summaries for CSGALNACT2 Gene

Entrez Gene Summary for CSGALNACT2 Gene

  • This gene encodes a member of the chondroitin N-acetylgalactosaminyltransferase family. The encoded protein is involved in elongation during chondroitin sulfate synthesis. A related pseudogene has been identified on chromosome X. [provided by RefSeq, Dec 2012]

GeneCards Summary for CSGALNACT2 Gene

CSGALNACT2 (Chondroitin Sulfate N-Acetylgalactosaminyltransferase 2) is a Protein Coding gene. Among its related pathways are Disease and Metabolism. GO annotations related to this gene include acetylgalactosaminyltransferase activity and glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity. An important paralog of this gene is B4GALNT4.

UniProtKB/Swiss-Prot for CSGALNACT2 Gene

  • Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSGALNACT2 Gene

Genomics for CSGALNACT2 Gene

Regulatory Elements for CSGALNACT2 Gene

Genomic Location for CSGALNACT2 Gene

Start:
43,138,445 bp from pter
End:
43,185,308 bp from pter
Size:
46,864 bases
Orientation:
Plus strand

Genomic View for CSGALNACT2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CSGALNACT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSGALNACT2 Gene

Proteins for CSGALNACT2 Gene

  • Protein details for CSGALNACT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N6G5-CGAT2_HUMAN
    Recommended name:
    Chondroitin sulfate N-acetylgalactosaminyltransferase 2
    Protein Accession:
    Q8N6G5
    Secondary Accessions:
    • B3KWL7
    • Q6MZJ5
    • Q6MZP6
    • Q8TCH4
    • Q9P1I6

    Protein attributes for CSGALNACT2 Gene

    Size:
    542 amino acids
    Molecular mass:
    62572 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF71068.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CSGALNACT2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CSGALNACT2 Gene

Proteomics data for CSGALNACT2 Gene at MOPED

Post-translational modifications for CSGALNACT2 Gene

  • Glycosylation at Asn41 and Asn333
  • Modification sites at PhosphoSitePlus

Other Protein References for CSGALNACT2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CSGALNACT2 Gene

Domains for CSGALNACT2 Gene

Gene Families for CSGALNACT2 Gene

HGNC:
  • B4GT :Beta 4-glycosyltransferases

Protein Domains for CSGALNACT2 Gene

Suggested Antigen Peptide Sequences for CSGALNACT2 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N6G5

UniProtKB/Swiss-Prot:

CGAT2_HUMAN :
  • Q8N6G5
Family:
  • Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
genes like me logo Genes that share domains with CSGALNACT2: view

Function for CSGALNACT2 Gene

Molecular function for CSGALNACT2 Gene

UniProtKB/Swiss-Prot CatalyticActivity: UDP-N-acetyl-D-galactosamine + beta-D-glucuronyl-(1->3)-D-galactosyl-proteoglycan = UDP + N-acetyl-D-galactosaminyl-(1->4)-beta-D-glucuronyl-(1->3)-beta-D-galactosylproteoglycan
UniProtKB/Swiss-Prot Function: Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains.

Enzyme Numbers (IUBMB) for CSGALNACT2 Gene

Gene Ontology (GO) - Molecular Function for CSGALNACT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008376 acetylgalactosaminyltransferase activity IDA 11788602
GO:0046872 metal ion binding IEA --
GO:0047237 glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity IEA --
genes like me logo Genes that share ontologies with CSGALNACT2: view

Phenotypes for CSGALNACT2 Gene

GenomeRNAi human phenotypes for CSGALNACT2:
genes like me logo Genes that share phenotypes with CSGALNACT2: view

miRNA for CSGALNACT2 Gene

miRTarBase miRNAs that target CSGALNACT2

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for CSGALNACT2 Gene

Localization for CSGALNACT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSGALNACT2 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CSGALNACT2 Gene COMPARTMENTS Subcellular localization image for CSGALNACT2 gene
Compartment Confidence
golgi apparatus 5
mitochondrion 2
cytosol 1
endoplasmic reticulum 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CSGALNACT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0016020 membrane IDA 19946888
GO:0030173 integral component of Golgi membrane NAS 11788602
GO:0032580 Golgi cisterna membrane IEA --
genes like me logo Genes that share ontologies with CSGALNACT2: view

Pathways for CSGALNACT2 Gene

genes like me logo Genes that share pathways with CSGALNACT2: view

Gene Ontology (GO) - Biological Process for CSGALNACT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0030166 proteoglycan biosynthetic process IDA 11788602
GO:0030203 glycosaminoglycan metabolic process TAS --
GO:0030204 chondroitin sulfate metabolic process TAS --
GO:0030206 chondroitin sulfate biosynthetic process TAS --
genes like me logo Genes that share ontologies with CSGALNACT2: view

Compounds for CSGALNACT2 Gene

(2) HMDB Compounds for CSGALNACT2 Gene

Compound Synonyms Cas Number PubMed IDs
Manganese
  • manganese
7439-96-5
Uridine diphosphate-N-acetylgalactosamine
  • UDP-N-acetyl-D-galactosamine
7277-98-7
genes like me logo Genes that share compounds with CSGALNACT2: view

Transcripts for CSGALNACT2 Gene

mRNA/cDNA for CSGALNACT2 Gene

Unigene Clusters for CSGALNACT2 Gene

Chondroitin sulfate N-acetylgalactosaminyltransferase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CSGALNACT2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11
SP1: - -
SP2: -
SP3: - -
SP4: -
SP5: - - -
SP6:
SP7: -

Relevant External Links for CSGALNACT2 Gene

GeneLoc Exon Structure for
CSGALNACT2
ECgene alternative splicing isoforms for
CSGALNACT2

Expression for CSGALNACT2 Gene

mRNA expression in normal human tissues for CSGALNACT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CSGALNACT2 Gene

This gene is overexpressed in Whole Blood (8.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CSGALNACT2 Gene

SOURCE GeneReport for Unigene cluster for CSGALNACT2 Gene Hs.657569

mRNA Expression by UniProt/SwissProt for CSGALNACT2 Gene

Q8N6G5-CGAT2_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expressions with CSGALNACT2: view

Orthologs for CSGALNACT2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CSGALNACT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CSGALNACT2 35
  • 99.69 (n)
  • 99.82 (a)
CSGALNACT2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CSGALNACT2 35
  • 94.03 (n)
  • 96.31 (a)
CSGALNACT2 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CSGALNACT2 35
  • 94.59 (n)
  • 96.49 (a)
CSGALNACT2 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Csgalnact2 35
  • 90.53 (n)
  • 92.62 (a)
Csgalnact2 16
Csgalnact2 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CSGALNACT2 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CSGALNACT2 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Csgalnact2 35
  • 90.34 (n)
  • 93.54 (a)
chicken
(Gallus gallus)
Aves CSGALNACT2 35
  • 78.69 (n)
  • 86.06 (a)
CSGALNACT2 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CSGALNACT2 36
  • 85 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii -- 35
csgalnact2 36
  • 73 (a)
OneToOne
LOC560826 35
  • 68.35 (n)
  • 73.27 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12913 36
  • 37 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6775 36
  • 35 (a)
OneToMany
Species with no ortholog for CSGALNACT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CSGALNACT2 Gene

ENSEMBL:
Gene Tree for CSGALNACT2 (if available)
TreeFam:
Gene Tree for CSGALNACT2 (if available)

Paralogs for CSGALNACT2 Gene

Paralogs for CSGALNACT2 Gene

Selected SIMAP similar genes for CSGALNACT2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for CSGALNACT2 Gene

genes like me logo Genes that share paralogs with CSGALNACT2: view

Variants for CSGALNACT2 Gene

Sequence variations from dbSNP and Humsavar for CSGALNACT2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1059483 -- 43,184,347(+) ATTAG(C/T)TTATT utr-variant-3-prime
rs1059484 -- 43,184,352(+) TTTAT(G/T)TGAGC utr-variant-3-prime
rs1864393 -- 43,163,205(-) TGGAG(C/T)AGTTA intron-variant, utr-variant-3-prime
rs1864394 -- 43,160,428(-) AGCAA(C/T)CACAT intron-variant
rs1864395 -- 43,160,249(-) TTTTG(C/T)TTTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CSGALNACT2 Gene

Variant ID Type Subtype PubMed ID
dgv644n71 CNV Loss 21882294
nsv513008 CNV Insertion 21212237
esv1015880 CNV Insertion 17803354
esv28818 CNV Gain 19812545

Relevant External Links for CSGALNACT2 Gene

HapMap Linkage Disequilibrium report
CSGALNACT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSGALNACT2 Gene

Disorders for CSGALNACT2 Gene

Relevant External Links for CSGALNACT2

Genetic Association Database (GAD)
CSGALNACT2
Human Genome Epidemiology (HuGE) Navigator
CSGALNACT2
genes like me logo Genes that share disorders with CSGALNACT2: view

No data available for UniProtKB/Swiss-Prot for CSGALNACT2 Gene

Publications for CSGALNACT2 Gene

  1. Differential roles of two N-acetylgalactosaminyltransferases, CSGalNAcT-1, and a novel enzyme, CSGalNAcT-2. Initiation and elongation in synthesis of chondroitin sulfate. (PMID: 12446672) Sato T. … Narimatsu H. (J. Biol. Chem. 2003) 2 3 4
  2. Molecular cloning and expression of a second chondroitin N- acetylgalactosaminyltransferase involved in the initiation and elongation of chondroitin/dermatan sulfate. (PMID: 12433924) Uyama T. … Sugahara K. (J. Biol. Chem. 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 48

Products for CSGALNACT2 Gene

Sources for CSGALNACT2 Gene

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