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CSGALNACT2 Gene

protein-coding   GIFtS: 54
GCID: GC10P043633

Chondroitin Sulfate N-Acetylgalactosaminyltransferase 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chondroitin Sulfate N-Acetylgalactosaminyltransferase 21 2     Beta 4 GalNAcT-22
CHGN22 3     Chondroitin Beta1,4 N-Acetylgalactosaminyltransferase 22
GALNACT22 3     Beta4GalNAcT-23
4 N-Acetylgalactosaminyltransferase 21     EC 2.4.1.1743
Chondroitin Beta11     GalNAcT-23
GALNACT-22     Chondroitin Beta-1,4-N-Acetylgalactosaminyltransferase 23

External Ids:    HGNC: 242921   Entrez Gene: 554542   Ensembl: ENSG000001698267   UniProtKB: Q8N6G53   

Export aliases for CSGALNACT2 gene to outside databases

Previous GC identifers: GC10P042954 GC10P040176


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CSGALNACT2 Gene:
This gene encodes a member of the chondroitin N-acetylgalactosaminyltransferase family. The encoded protein is
involved in elongation during chondroitin sulfate synthesis. A related pseudogene has been identified on
chromosome X. (provided by RefSeq, Dec 2012)

GeneCards Summary for CSGALNACT2 Gene:
CSGALNACT2 (chondroitin sulfate N-acetylgalactosaminyltransferase 2) is a protein-coding gene. GO annotations related to this gene include glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity and acetylgalactosaminyltransferase activity. An important paralog of this gene is CSGALNACT1.

UniProtKB/Swiss-Prot: CGAT2_HUMAN, Q8N6G5
Function: Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid
(GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of
chondroitin chains




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CSGALNACT2 gene promoter:
         AhR   NF-1   RFX1   AML1a   CUTL1   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   MZF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCSGALNACT2 promoter sequence
   Search Chromatin IP Primers for CSGALNACT2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CSGALNACT2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q11.21   Ensembl cytogenetic band:  10q11.21   HGNC cytogenetic band: 10q11.21

CSGALNACT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CSGALNACT2 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P043633:  view genomic region     (about GC identifiers)

Start:
43,633,934 bp from pter      End:
43,680,756 bp from pter
Size:
46,823 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CGAT2_HUMAN, Q8N6G5 (See protein sequence)
Recommended Name: Chondroitin sulfate N-acetylgalactosaminyltransferase 2  
Size: 542 amino acids; 62572 Da
Sequence caution: Sequence=AAF71068.1; Type=Erroneous initiation;
Secondary accessions: B3KWL7 Q6MZJ5 Q6MZP6 Q8TCH4 Q9P1I6
Alternative splicing: 2 isoforms:  Q8N6G5-1   Q8N6G5-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CSGALNACT2: NX_Q8N6G5

Explore proteomics data for CSGALNACT2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn41, Asn333

  • See CSGALNACT2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_061060.3  
    ENSEMBL proteins: 
     ENSP00000363590   ENSP00000363588  
    Reactome Protein details: Q8N6G5

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    B4GT: Beta 4-glycosyltransferases

    1 InterPro protein domain:
     IPR008428 Chond_GalNAc

    Graphical View of Domain Structure for InterPro Entry Q8N6G5

    ProtoNet protein and cluster: Q8N6G5

    UniProtKB/Swiss-Prot: CGAT2_HUMAN, Q8N6G5
    Similarity: Belongs to the chondroitin N-acetylgalactosaminyltransferase family


    Find genes that share domains with CSGALNACT2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CGAT2_HUMAN, Q8N6G5
    Function: Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid
    (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of
    chondroitin chains
    Catalytic activity: UDP-N-acetyl-D-galactosamine + beta-D-glucuronyl-(1->3)-D-galactosyl-proteoglycan = UDP +
    N-acetyl-D-galactosaminyl-(1->4)-beta-D-glucuronyl-(1->3)-beta-D-galactosylproteoglycan

         Enzyme Number (IUBMB): EC 2.4.1.1741

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008376acetylgalactosaminyltransferase activity IDA11788602
    GO:0016758transferase activity, transferring hexosyl groups ----
    GO:0046872metal ion binding IEA--
    GO:0047237glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity IEA--
         
    Find genes that share ontologies with CSGALNACT2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CSGALNACT2:
     Synthetic lethal with c-Myc af 

    Animal Models:
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    Selected qRT-PCR Assays for microRNAs that regulate CSGALNACT2 (see all 11):
    hsa-miR-3163 hsa-miR-217 hsa-miR-520f hsa-miR-1263 hsa-miR-125a-3p hsa-miR-512-3p hsa-miR-373* hsa-miR-583
    SwitchGear 3'UTR luciferase reporter plasmidCSGALNACT2 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CGAT2_HUMAN, Q8N6G5: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    mitochondrion2
    cytosol1
    endoplasmic reticulum1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0030173integral component of Golgi membrane NAS11788602
    GO:0032580Golgi cisterna membrane IEA--

    Find genes that share ontologies with CSGALNACT2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CSGALNACT2 About    
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1MPS VI - Maroteaux-Lamy syndrome
    MPS VI - Maroteaux-Lamy syndrome0.45
    MPS IIID - Sanfilippo syndrome D0.45
    MPS IIIC - Sanfilippo syndrome C0.45
    MPS I - Hurler syndrome0.45
    MPS IV - Morquio syndrome A0.45
    MPS IV - Morquio syndrome B0.45
    MPS IIIA - Sanfilippo syndrome A0.45
    MPS VII - Sly syndrome0.45
    2Chondroitin sulfate/dermatan sulfate metabolism
    Chondroitin sulfate/dermatan sulfate metabolism0.51
    Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate0.00
    Chondroitin sulfate biosynthesis0.41
    3Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    4dermatan sulfate biosynthesis
    dermatan sulfate biosynthesis
    chondroitin and dermatan biosynthesis0.00
    5Disease
    Disease


    Find genes that share SuperPaths with CSGALNACT2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4 BioSystems Pathways for CSGALNACT2
        chondroitin and dermatan biosynthesis
    chondroitin sulfate biosynthesis (late stages)
    chondroitin sulfate biosynthesis
    dermatan sulfate biosynthesis


    1 Reactome Pathway for CSGALNACT2
        Chondroitin sulfate biosynthesis


    2 Kegg Pathways  (Kegg details for CSGALNACT2):
        Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
    Metabolic pathways

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CSGALNACT2
    Interactions:

        Search GeneGlobe Interaction Network for CSGALNACT2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for CSGALNACT2 (ENSP000003635904) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    B3GAT1ENSP000003078754STRING: ENSP00000307875
    B3GAT2ENSP000002300534STRING: ENSP00000230053
    B3GAT3ENSP000002654714STRING: ENSP00000265471
    CHPFENSP000002437764STRING: ENSP00000243776
    CHPF2ENSP000000353074STRING: ENSP00000035307
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0030166proteoglycan biosynthetic process IDA11788602
    GO:0030203glycosaminoglycan metabolic process TAS--
    GO:0030204chondroitin sulfate metabolic process TAS--
    GO:0030206chondroitin sulfate biosynthetic process TAS--

    Find genes that share ontologies with CSGALNACT2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for CSGALNACT2 (CGAT2)

    2 HMDB Compounds for CSGALNACT2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Manganesemanganese 7439-96-5--
    Uridine diphosphate-N-acetylgalactosamineUDP-N-acetyl-D-galactosamine (see all 17)7277-98-7--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CSGALNACT2 gene: 
    NM_018590.4  

    Unigene Cluster for CSGALNACT2:

    Chondroitin sulfate N-acetylgalactosaminyltransferase 2
    Hs.657569  [show with all ESTs]
    Unigene Representative Sequence: BX647369
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374466(uc001jan.3) ENST00000374464(uc001jam.1)
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    Additional mRNA sequence: 

    AB079252.1 AB090811.1 AF086458.1 AF116646.1 AK074474.1 AK125300.1 BC030268.1 BX640967.1 
    BX641073.1 BX647369.1 

    8 DOTS entries:

    DT.313056  DT.99987843  DT.95218930  DT.121238832  DT.75124647  DT.87009799  DT.75138315  DT.95367561 

    Selected AceView cDNA sequences (see all 127):

    AA721408 AV729184 AA235741 AB079252 AK074474 CA390490 BX102005 AW152164 
    AI673813 AA749137 AI282011 AK125300 BU070975 BF939999 AW075768 AA825719 
    CD365706 AI356844 BX640967 BQ437930 AA321947 AI270631 CD677705 AI674924 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CSGALNACT2 (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11
    SP1:                                                        -                 -                                 
    SP2:                                                        -                                                   
    SP3:                                                                    -     -                                 
    SP4:                                                                                            -               
    SP5:        -     -     -                                                                                       


    ECgene alternative splicing isoforms for CSGALNACT2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CSGALNACT2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATCTGTTAC
    CSGALNACT2 Expression
    About this image


    CSGALNACT2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Bone (Muscoskeletal System)
             Bone Marrow
    CSGALNACT2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CSGALNACT2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.657569

    UniProtKB/Swiss-Prot: CGAT2_HUMAN, Q8N6G5
    Tissue specificity: Ubiquitous

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CSGALNACT2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Csgalnact21 , 5 chondroitin sulfate N-acetylgalactosaminyltransferase more1, 5 90.53(n)1
    92.62(a)1
      6 (55.86 cM)5
    787521  NM_030165.31  NP_084441.31 
     1181074525 
    chicken
    (Gallus gallus)
    Aves CSGALNACT21 chondroitin sulfate N-acetylgalactosaminyltransferase more 78.69(n)
    86.06(a)
      423632  XM_421516.4  XP_421516.2 
    lizard
    (Anolis carolinensis)
    Reptilia CSGALNACT26
    chondroitin sulfate N-acetylgalactosaminyltransfer...
    85(a)
    1 ↔ 1
    GL343233.1(709378-730863)
    zebrafish
    (Danio rerio)
    Actinopterygii BU744178.12   -- 82.08(n)   337862  BU744178.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG129136
    --
    37(a)
    1 → many
    2R(6136762-6142479)


    ENSEMBL Gene Tree for CSGALNACT2 (if available)
    TreeFam Gene Tree for CSGALNACT2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CSGALNACT2 gene
    CSGALNACT12  CHSY32  CHPF2  B4GALNT32  CHSY12  CHPF22  B4GALNT42  
    2 SIMAP similar genes for CSGALNACT2 using alignment to 1 protein entry:     CGAT2_HUMAN:
    CSGALNACT1    ChGn

    Find genes that share paralogs with CSGALNACT2           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for CSGALNACT2
    PGOHUM00000241908 PGOHUM00000250082


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CSGALNACT2 (see all 1005)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1424059131,2
    C--43631950(+) CTAGAA/GATGCC 1 -- us2k10--------
    rs1459335191,2
    --43631966(+) AATGAA/GAATCA 1 -- us2k10--------
    rs745793271,2
    C,F--43632021(+) CTCCAC/TGCAGA 1 -- us2k11Minor allele frequency- T:0.03EA 120
    rs1912527751,2
    --43632176(+) AAAACC/TGTGGA 1 -- us2k10--------
    rs1420206551,2
    C--43632223(+) CAGGG-/GAATCAG 1 -- us2k10--------
    rs1154260201,2
    F--43632415(+) ATTTTA/TCAACT 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1386186181,2
    --43632660(+) CGCTTC/GAGCCC 1 -- us2k10--------
    rs114535451,2
    C--43632713(+) AAAAA-/ATATTA 1 -- us2k1 tfbs30--------
    rs1843515921,2
    --43632773(+) TACTCA/GGGAGG 1 -- us2k10--------
    rs1897319841,2
    --43632891(+) TAGATG/TAATAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CSGALNACT2 (43633934 - 43680756 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CSGALNACT2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1015880CNV Insertion17803354
    nsv513008CNV Insertion21212237
    dgv644n71CNV Loss21882294
    esv28818CNV Gain19812545

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CSGALNACT2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with CSGALNACT2           About GenesLikeMe

    Genetic Association Database (GAD): CSGALNACT2
    Human Genome Epidemiology (HuGE) Navigator: CSGALNACT2 (1 document)

    Export disorders for CSGALNACT2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CSGALNACT2 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with CSGALNACT2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Differential roles of two N-acetylgalactosaminyltransferases, CSGalNAcT-1, and a novel enzyme, CSGalNAcT-2. Initiation and elongation in synthesis of chondroitin sulfate. (PubMed id 12446672)1, 2, 3 Sato T.... Narimatsu H. (J. Biol. Chem. 2003)
    2. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Molecular cloning and expression of a second chondroitin N- acetylgalactosaminyltransferase involved in the initiation and elongation of chondroitin/dermatan sulfate. (PubMed id 12433924)1, 2 Uyama T.... Sugahara K. (J. Biol. Chem. 2003)
    6. Simultaneous siRNA-mediated silencing of pairs of genes coding for enzymes involved in glycosaminoglycan synthesis. (PubMed id 22590693)1 Dziedzic D....JakA^bkiewicz-Banecka J. (Acta Biochim. Pol. 2012)
    7. Genome-wide association study identifies NRG1 as a susceptibility locus for Hirschsprung's disease. (PubMed id 19196962)1 Garcia-Barcelo M.M....Tam P.K. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    8. Expression of genes encoding for proteins involved in heparan sulphate and chondroitin sulphate chain synthesis and modification in normal and malignant plasma cells. (PubMed id 19298595)1 Bret C....Klein B. (Br. J. Haematol. 2009)
    9. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    10. Molecular cloning and expression of human chondroitin N- acetylgalactosaminyltransferase: key enzyme for chain initiation and elongation of chondroitin/dermatan sulfate on the protein linkage region tetrasaccharide shared by heparin/heparan sulfate. (PubMed id 11788602)1 Uyama T.... Sugahara K. (J. Biol. Chem. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55454 HGNC: 24292 AceView: GALNACT-2 Ensembl:ENSG00000169826 euGenes: HUgn55454
    ECgene: CSGALNACT2 Kegg: 55454 H-InvDB: CSGALNACT2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CSGALNACT2 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=CSGALNACT2
    Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_478

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CSGALNACT2 gene:
    Search GeneIP for patents involving CSGALNACT2

    GeneCards and IP:
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