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Aliases for CSGALNACT1 Gene

Aliases for CSGALNACT1 Gene

  • Chondroitin Sulfate N-Acetylgalactosaminyltransferase 1 2 3
  • Chondroitin Beta-1,4-N-Acetylgalactosaminyltransferase 1 3 4
  • Chondroitin Beta1,4 N-Acetylgalactosaminyltransferase 2 3
  • Beta4GalNAcT-1 3 4
  • CSGalNAcT-1 3 4
  • ChGn 3 4
  • Beta4GalNAcT 3
  • EC 2.4.1.174 4
  • GALNACT1 4

External Ids for CSGALNACT1 Gene

Previous GeneCards Identifiers for CSGALNACT1 Gene

  • GC08M019306
  • GC08M017801

Summaries for CSGALNACT1 Gene

GeneCards Summary for CSGALNACT1 Gene

CSGALNACT1 (Chondroitin Sulfate N-Acetylgalactosaminyltransferase 1) is a Protein Coding gene. Among its related pathways are Disease and Metabolism. GO annotations related to this gene include glucuronosyltransferase activity and glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity. An important paralog of this gene is B4GALNT4.

UniProtKB/Swiss-Prot for CSGALNACT1 Gene

  • Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains. Important role in chondroitin chain biosynthesis in cartilage.

Gene Wiki entry for CSGALNACT1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSGALNACT1 Gene

Genomics for CSGALNACT1 Gene

Regulatory Elements for CSGALNACT1 Gene

Genomic Location for CSGALNACT1 Gene

Start:
19,404,161 bp from pter
End:
19,758,029 bp from pter
Size:
353,869 bases
Orientation:
Minus strand

Genomic View for CSGALNACT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CSGALNACT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSGALNACT1 Gene

Proteins for CSGALNACT1 Gene

  • Protein details for CSGALNACT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TDX6-CGAT1_HUMAN
    Recommended name:
    Chondroitin sulfate N-acetylgalactosaminyltransferase 1
    Protein Accession:
    Q8TDX6
    Secondary Accessions:
    • B2RBE4
    • Q6P9G6
    • Q8IUF9
    • Q9NSQ7
    • Q9NUM9

    Protein attributes for CSGALNACT1 Gene

    Size:
    532 amino acids
    Molecular mass:
    61294 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CSGALNACT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CSGALNACT1 Gene

Proteomics data for CSGALNACT1 Gene at MOPED

Post-translational modifications for CSGALNACT1 Gene

Other Protein References for CSGALNACT1 Gene

Antibody Products

No data available for DME Specific Peptides for CSGALNACT1 Gene

Domains for CSGALNACT1 Gene

Gene Families for CSGALNACT1 Gene

HGNC:
  • B4GT :Beta 4-glycosyltransferases

Protein Domains for CSGALNACT1 Gene

Suggested Antigen Peptide Sequences for CSGALNACT1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TDX6

UniProtKB/Swiss-Prot:

CGAT1_HUMAN :
  • Q8TDX6
Family:
  • Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
genes like me logo Genes that share domains with CSGALNACT1: view

Function for CSGALNACT1 Gene

Molecular function for CSGALNACT1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: UDP-N-acetyl-D-galactosamine + beta-D-glucuronyl-(1->3)-D-galactosyl-proteoglycan = UDP + N-acetyl-D-galactosaminyl-(1->4)-beta-D-glucuronyl-(1->3)-beta-D-galactosylproteoglycan
UniProtKB/Swiss-Prot Function: Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains. Important role in chondroitin chain biosynthesis in cartilage.

Enzyme Numbers (IUBMB) for CSGALNACT1 Gene

Gene Ontology (GO) - Molecular Function for CSGALNACT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008376 acetylgalactosaminyltransferase activity ISS 11788602
GO:0008955 peptidoglycan glycosyltransferase activity IDA 11514575
GO:0015020 glucuronosyltransferase activity IDA 11514575
GO:0046872 metal ion binding NAS 12163485
GO:0047237 glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity IDA 12163485
genes like me logo Genes that share ontologies with CSGALNACT1: view
genes like me logo Genes that share phenotypes with CSGALNACT1: view

Animal Models for CSGALNACT1 Gene

MGI Knock Outs for CSGALNACT1:

Animal Model Products

CRISPR Products

miRNA for CSGALNACT1 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CSGALNACT1

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for CSGALNACT1 Gene

Localization for CSGALNACT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSGALNACT1 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CSGALNACT1 Gene COMPARTMENTS Subcellular localization image for CSGALNACT1 gene
Compartment Confidence
golgi apparatus 5
endoplasmic reticulum 2
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CSGALNACT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005622 intracellular IC 12163485
GO:0030173 integral component of Golgi membrane NAS 11514575
GO:0032580 Golgi cisterna membrane IEA --
genes like me logo Genes that share ontologies with CSGALNACT1: view

Pathways for CSGALNACT1 Gene

genes like me logo Genes that share pathways with CSGALNACT1: view

Interacting Proteins for CSGALNACT1 Gene

Gene Ontology (GO) - Biological Process for CSGALNACT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001958 endochondral ossification IEA --
GO:0005975 carbohydrate metabolic process TAS --
GO:0007399 nervous system development NAS 11514575
GO:0008037 cell recognition NAS 11514575
GO:0008283 cell proliferation NAS 11514575
genes like me logo Genes that share ontologies with CSGALNACT1: view

Compounds for CSGALNACT1 Gene

(1) HMDB Compounds for CSGALNACT1 Gene

Compound Synonyms Cas Number PubMed IDs
Uridine diphosphate-N-acetylgalactosamine
  • UDP-N-acetyl-D-galactosamine
7277-98-7
genes like me logo Genes that share compounds with CSGALNACT1: view

Transcripts for CSGALNACT1 Gene

Unigene Clusters for CSGALNACT1 Gene

Chondroitin sulfate N-acetylgalactosaminyltransferase 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CSGALNACT1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CSGALNACT1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CSGALNACT1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d · 11e · 11f · 11g ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: - - - - - -
SP2: - - -
SP3: - -
SP4: - - - - - - - - -
SP5: - - - - - - - -
SP6: - - - - - -
SP7: - - - - -
SP8: - - - -
SP9: - - -
SP10:

Relevant External Links for CSGALNACT1 Gene

GeneLoc Exon Structure for
CSGALNACT1
ECgene alternative splicing isoforms for
CSGALNACT1

Expression for CSGALNACT1 Gene

mRNA expression in normal human tissues for CSGALNACT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for CSGALNACT1 Gene

SOURCE GeneReport for Unigene cluster for CSGALNACT1 Gene Hs.613729

mRNA Expression by UniProt/SwissProt for CSGALNACT1 Gene

Q8TDX6-CGAT1_HUMAN
Tissue specificity: Ubiquitous, with the highest levels in placenta, thyroid, bladder, prostate and adrenal gland. Detected at low levels in the other tissues examined.
genes like me logo Genes that share expressions with CSGALNACT1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CSGALNACT1 Gene

Orthologs for CSGALNACT1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CSGALNACT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CSGALNACT1 35
  • 99.37 (n)
  • 99.62 (a)
CSGALNACT1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CSGALNACT1 35
  • 82.25 (n)
  • 85.31 (a)
CSGALNACT1 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CSGALNACT1 35
  • 87.56 (n)
  • 91.1 (a)
CSGALNACT1 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Csgalnact1 35
  • 85.69 (n)
  • 92.65 (a)
Csgalnact1 16
Csgalnact1 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CSGALNACT1 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CSGALNACT1 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Csgalnact1 35
  • 85.61 (n)
  • 91.33 (a)
chicken
(Gallus gallus)
Aves CSGALNACT1 35
  • 75.47 (n)
  • 79.96 (a)
CSGALNACT1 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CSGALNACT1 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia csgalnact1 35
  • 71.8 (n)
  • 80.73 (a)
zebrafish
(Danio rerio)
Actinopterygii CSGALNACT1 (1 of 2) 36
  • 65 (a)
OneToMany
CSGALNACT1 (2 of 2) 36
  • 53 (a)
OneToMany
LOC793671 35
  • 68.65 (n)
  • 71.92 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007720 35
  • 50.85 (n)
  • 44.99 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12913 35
  • 51.84 (n)
  • 45.37 (a)
CG12913 36
  • 38 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6775 36
  • 37 (a)
OneToMany
Species with no ortholog for CSGALNACT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CSGALNACT1 Gene

ENSEMBL:
Gene Tree for CSGALNACT1 (if available)
TreeFam:
Gene Tree for CSGALNACT1 (if available)

Paralogs for CSGALNACT1 Gene

Paralogs for CSGALNACT1 Gene

Selected SIMAP similar genes for CSGALNACT1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CSGALNACT1: view

Variants for CSGALNACT1 Gene

Sequence variations from dbSNP and Humsavar for CSGALNACT1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs3185 -- 19,471,448(+) tgaat(G/T)ttcct intron-variant
rs867930 -- 19,640,576(+) TACAT(A/T)AGAAA intron-variant
rs873936 -- 19,633,917(+) CTGCA(C/G)TAACC intron-variant
rs923764 -- 19,709,909(-) AATGT(A/T)CTGTA intron-variant
rs923765 -- 19,706,389(-) TCCGC(C/T)GCAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CSGALNACT1 Gene

Variant ID Type Subtype PubMed ID
dgv7748n71 CNV Gain 21882294
nsv522185 CNV Gain 19592680
nsv890622 CNV Gain 21882294
esv34007 CNV Loss 18971310
esv2661905 CNV Deletion 23128226
nsv890623 CNV Gain 21882294
esv2736721 CNV Deletion 23290073
esv2736722 CNV Deletion 23290073
esv2736723 CNV Deletion 23290073
esv27125 CNV Loss 19812545
esv3485 CNV Deletion 18987735
nsv512944 CNV Insertion 21212237
nsv890624 CNV Loss 21882294
esv2736724 CNV Deletion 23290073
esv2736725 CNV Deletion 23290073
esv2736726 CNV Deletion 23290073
esv998128 CNV Deletion 20482838
esv1000464 CNV Deletion 20482838
esv1429388 CNV Deletion 17803354
nsv396275 CNV Loss 16902084
nsv6104 CNV Insertion 18451855
nsv890625 CNV Gain 21882294
esv24822 CNV Loss 19812545
nsv890626 CNV Gain 21882294
esv267971 CNV Insertion 20981092
nsv890627 CNV Gain 21882294
nsv525772 CNV Loss 19592680
nsv465601 CNV Loss 19166990
nsv6105 CNV Insertion 18451855
nsv527023 CNV Loss 19592680
nsv6106 CNV Loss 18451855
nsv527615 CNV Loss 19592680
esv2481095 CNV Deletion 19546169
esv2405754 CNV Deletion 18987734
esv2736727 CNV Deletion 23290073
esv2736728 CNV Deletion 23290073
nsv890628 CNV Loss 21882294
esv2656596 CNV Deletion 23128226
dgv880n27 CNV Loss 19166990
nsv470203 CNV Loss 18288195

Relevant External Links for CSGALNACT1 Gene

HapMap Linkage Disequilibrium report
CSGALNACT1
Human Gene Mutation Database (HGMD)
CSGALNACT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSGALNACT1 Gene

Disorders for CSGALNACT1 Gene

(1) University of Copenhagen DISEASES for CSGALNACT1 Gene

Relevant External Links for CSGALNACT1

Genetic Association Database (GAD)
CSGALNACT1
Human Genome Epidemiology (HuGE) Navigator
CSGALNACT1
genes like me logo Genes that share disorders with CSGALNACT1: view

No data available for UniProtKB/Swiss-Prot for CSGALNACT1 Gene

Publications for CSGALNACT1 Gene

  1. Differential roles of two N-acetylgalactosaminyltransferases, CSGalNAcT-1, and a novel enzyme, CSGalNAcT-2. Initiation and elongation in synthesis of chondroitin sulfate. (PMID: 12446672) Sato T. … Narimatsu H. (J. Biol. Chem. 2003) 2 3 4
  2. Chondroitin sulfate N-acetylgalactosaminyltransferase-1 plays a critical role in chondroitin sulfate synthesis in cartilage. (PMID: 17145758) Sakai K. … Watanabe H. (J. Biol. Chem. 2007) 2 3 4
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for CSGALNACT1 Gene

Sources for CSGALNACT1 Gene

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