Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CSGALNACT1 Gene

protein-coding   GIFtS: 56
GCID: GC08M019306

Chondroitin Sulfate N-Acetylgalactosaminyltransferase 1

  Search for CSGALNACT1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Chondroitin Sulfate N-Acetylgalactosaminyltransferase 11 2     beta4GalNAcT-12
Chondroitin Beta-1,4-N-Acetylgalactosaminyltransferase 12 3     Chondroitin Beta1,4 N-Acetylgalactosaminyltransferase2
4 N-Acetylgalactosaminyltransferase1     Beta4GalNAcT-13
Chondroitin Beta11     CHGN3
CSGalNAcT-12     CsGalNAcT-13
ChGn2     EC 2.4.1.1743
beta4GalNAcT2     GALNACT13

External Ids:    HGNC: 242901   Entrez Gene: 557902   Ensembl: ENSG000001474087   UniProtKB: Q8TDX63   

Export aliases for CSGALNACT1 gene to outside databases

Previous GC identifer: GC08M017801


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for CSGALNACT1 Gene:
CSGALNACT1 (chondroitin sulfate N-acetylgalactosaminyltransferase 1) is a protein-coding gene. GO annotations related to this gene include glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity and glucuronosyltransferase activity. An important paralog of this gene is CHSY3.

UniProtKB/Swiss-Prot: CGAT1_HUMAN, Q8TDX6
Function: Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid
(GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of
chondroitin chains. Important role in chondroitin chain biosynthesis in cartilage

Gene Wiki entry for CSGALNACT1 (ChGn) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000008.11  NT_167187.2  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CSGALNACT1 gene promoter:
         TBP   NF-1   FOXJ2 (long isoform)   POU6F1 (c2)   FOXJ2   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CSGALNACT1 promoter sequence
   Search Chromatin IP Primers for CSGALNACT1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CSGALNACT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p21.3   Ensembl cytogenetic band:  8p21.3   HGNC cytogenetic band: 8p21.3

CSGALNACT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CSGALNACT1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M019306:  view genomic region     (about GC identifiers)

Start:
19,261,672 bp from pter      End:
19,615,540 bp from pter
Size:
353,869 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for CSGALNACT1

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CGAT1_HUMAN, Q8TDX6 (See protein sequence)
Recommended Name: Chondroitin sulfate N-acetylgalactosaminyltransferase 1  
Size: 532 amino acids; 61294 Da
Secondary accessions: B2RBE4 Q6P9G6 Q8IUF9 Q9NSQ7 Q9NUM9
Alternative splicing: 3 isoforms:  Q8TDX6-1   Q8TDX6-2   Q8TDX6-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CSGALNACT1: NX_Q8TDX6

Explore proteomics data for CSGALNACT1 at MOPED

Post-translational modifications: 

  • N-glycosylated1
  • Glycosylation2 at Asn315, Asn324

  • See CSGALNACT1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001123990.1  NP_060841.5  

    ENSEMBL proteins: 
     ENSP00000411816   ENSP00000330805   ENSP00000381084   ENSP00000429809   ENSP00000428216  
     ENSP00000428089   ENSP00000429130   ENSP00000428774   ENSP00000427740   ENSP00000310891  
     ENSP00000442155  
    Reactome Protein details: Q8TDX6

    CSGALNACT1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CSGALNACT1
    GenScript Custom Purified and Recombinant Proteins Services for CSGALNACT1
    Novus Biologicals CSGALNACT1 Protein
    Novus Biologicals CSGALNACT1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CSGALNACT1

     
    Search eBioscience for Proteins for CSGALNACT1 

    CSGALNACT1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for CSGALNACT1
    OriGene Custom Antibody Services for CSGALNACT1
    Novus Biologicals CSGALNACT1 Antibodies
    Abcam antibodies for CSGALNACT1
    Cloud-Clone Corp. Antibodies for CSGALNACT1
    ThermoFisher Antibodies for CSGALNACT1
    LSBio Antibodies in human, mouse, rat for CSGALNACT1

    CSGALNACT1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CSGALNACT1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CSGALNACT1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CSGALNACT1
    Cloud-Clone Corp. CLIAs for CSGALNACT1
    Search eBioscience for ELISAs for CSGALNACT1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    B4GT: Beta 4-glycosyltransferases

    1 InterPro protein domain:
     IPR008428 Chond_GalNAc

    Graphical View of Domain Structure for InterPro Entry Q8TDX6

    ProtoNet protein and cluster: Q8TDX6

    UniProtKB/Swiss-Prot: CGAT1_HUMAN, Q8TDX6
    Similarity: Belongs to the chondroitin N-acetylgalactosaminyltransferase family


    Find genes that share domains with CSGALNACT1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CGAT1_HUMAN, Q8TDX6
    Function: Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid
    (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of
    chondroitin chains. Important role in chondroitin chain biosynthesis in cartilage
    Catalytic activity: UDP-N-acetyl-D-galactosamine + beta-D-glucuronyl-(1->3)-D-galactosyl-proteoglycan = UDP +
    N-acetyl-D-galactosaminyl-(1->4)-beta-D-glucuronyl-(1->3)-beta-D-galactosylproteoglycan

         Enzyme Number (IUBMB): EC 2.4.1.1741

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008376acetylgalactosaminyltransferase activity ISS11788602
    GO:0008955peptidoglycan glycosyltransferase activity IDA11514575
    GO:0015020glucuronosyltransferase activity IDA11514575
    GO:0016758transferase activity, transferring hexosyl groups ----
    GO:0046872metal ion binding NAS12163485
         
    Find genes that share ontologies with CSGALNACT1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CSGALNACT1:
     Increased gamma-H2AX phosphory 

         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Csgalnact1):
     behavior/neurological  craniofacial  growth/size/body  limbs/digits/tail  mortality/aging 
     reproductive system  skeleton 

    Find genes that share phenotypes with CSGALNACT1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CSGALNACT1: Csgalnact1tm1Lex Csgalnact1tm1.1Nari Csgalnact1tm1.1Migar

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CSGALNACT1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CSGALNACT1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CSGALNACT1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CSGALNACT1

    miRNA
    Products:
        
    miRTarBase miRNAs that target CSGALNACT1:
    hsa-mir-16-5p (MIRT051118), hsa-mir-335-5p (MIRT017694), hsa-mir-124-3p (MIRT022557), hsa-mir-126-5p (MIRT045696)

    Block miRNA regulation of human, mouse, rat CSGALNACT1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CSGALNACT1 (see all 25):
    hsa-miR-106a hsa-miR-218-1* hsa-miR-218 hsa-miR-519a hsa-miR-9 hsa-miR-93 hsa-miR-199b-5p hsa-miR-205*
    SwitchGear 3'UTR luciferase reporter plasmidCSGALNACT1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CSGALNACT1
    Predesigned siRNA for gene silencing in human, mouse, rat CSGALNACT1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CSGALNACT1

    Clone
    Products:
         
    OriGene clones in human, mouse for CSGALNACT1 (see all 12)
    OriGene ORF clones in mouse, rat for CSGALNACT1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CSGALNACT1 (NM_018371)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CSGALNACT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSGALNACT1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CSGALNACT1
    Browse ESI BIO Cell Lines and PureStem Progenitors for CSGALNACT1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSGALNACT1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    CGAT1_HUMAN, Q8TDX6: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    endoplasmic reticulum2
    extracellular1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005622intracellular IC12163485
    GO:0030173integral component of Golgi membrane NAS11514575
    GO:0032580Golgi cisterna membrane IEA--

    Find genes that share ontologies with CSGALNACT1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for CSGALNACT1 About    
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1MPS VI - Maroteaux-Lamy syndrome
    MPS VI - Maroteaux-Lamy syndrome0.45
    MPS IIID - Sanfilippo syndrome D0.45
    MPS IIIC - Sanfilippo syndrome C0.45
    MPS I - Hurler syndrome0.45
    MPS IV - Morquio syndrome A0.45
    MPS IV - Morquio syndrome B0.45
    MPS IIIA - Sanfilippo syndrome A0.45
    MPS VII - Sly syndrome0.45
    2Chondroitin sulfate/dermatan sulfate metabolism
    Chondroitin sulfate/dermatan sulfate metabolism0.51
    Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate0.00
    Chondroitin sulfate biosynthesis0.41
    3Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    4dermatan sulfate biosynthesis
    dermatan sulfate biosynthesis
    chondroitin and dermatan biosynthesis0.00
    5Disease
    Disease


    Find genes that share SuperPaths with CSGALNACT1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4 BioSystems Pathways for CSGALNACT1
        chondroitin and dermatan biosynthesis
    chondroitin sulfate biosynthesis (late stages)
    chondroitin sulfate biosynthesis
    dermatan sulfate biosynthesis

    1 Reactome Pathway for CSGALNACT1
        Chondroitin sulfate biosynthesis


    2 Kegg Pathways  (Kegg details for CSGALNACT1):
        Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
    Metabolic pathways

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CSGALNACT1
    Interactions:

        Search GeneGlobe Interaction Network for CSGALNACT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    Selected Interacting proteins for CSGALNACT1 (ENSP000003108914) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    B3GAT2ENSP000002300534STRING: ENSP00000230053
    B3GAT3ENSP000002654714STRING: ENSP00000265471
    BGNENSP000003273364STRING: ENSP00000327336
    CHPFENSP000002437764STRING: ENSP00000243776
    CHPF2ENSP000000353074STRING: ENSP00000035307
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001958endochondral ossification IEA--
    GO:0005975carbohydrate metabolic process TAS--
    GO:0007399nervous system development NAS11514575
    GO:0008037cell recognition NAS11514575
    GO:0008283cell proliferation NAS11514575

    Find genes that share ontologies with CSGALNACT1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CSGALNACT1 (CGAT1)

    1 HMDB Compound for CSGALNACT1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Uridine diphosphate-N-acetylgalactosamineUDP-N-acetyl-D-galactosamine (see all 17)7277-98-7--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for CSGALNACT1 gene (2 alternative transcripts): 
    NM_001130518.1  NM_018371.4  

    Unigene Cluster for CSGALNACT1:

    Chondroitin sulfate N-acetylgalactosaminyltransferase 1
    Hs.613729  [show with all ESTs]
    Unigene Representative Sequence: NM_001130518
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000454498(uc011kyn.2) ENST00000332246(uc011kyo.2 uc011kyp.2)
    ENST00000397998(uc003wzg.3) ENST00000522854 ENST00000518542 ENST00000519222(uc003wzh.2)
    ENST00000523262 ENST00000517494 ENST00000520003 ENST00000524213 ENST00000517651
    ENST00000523227 ENST00000522732 ENST00000522573 ENST00000523919 ENST00000524112
    ENST00000311540 ENST00000544602
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CSGALNACT1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CSGALNACT1 (see all 25):
    hsa-miR-106a hsa-miR-218-1* hsa-miR-218 hsa-miR-519a hsa-miR-9 hsa-miR-93 hsa-miR-199b-5p hsa-miR-205*
    SwitchGear 3'UTR luciferase reporter plasmidCSGALNACT1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CSGALNACT1
    Predesigned siRNA for gene silencing in human, mouse, rat CSGALNACT1
    Clone
    Products:
         
    OriGene clones in human, mouse for CSGALNACT1 (see all 12)
    OriGene ORF clones in mouse, rat for CSGALNACT1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CSGALNACT1 (NM_018371)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CSGALNACT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSGALNACT1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CSGALNACT1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CSGALNACT1
      QuantiTect SYBR Green Assays in human, mouse, rat CSGALNACT1
      QuantiFast Probe-based Assays in human, mouse, rat CSGALNACT1

    Additional mRNA sequence: 

    AB071403.1 AB081516.1 AK002124.1 AK002126.1 AK314625.1 AL157483.1 AY358441.1 BC033525.1 
    BC048103.1 BX649103.1 NR_024040.1 

    16 DOTS entries:

    DT.101980618  DT.100693054  DT.91649525  DT.101958464  DT.210633  DT.92037715  DT.65284987  DT.120638413 
    DT.120638423  DT.120638429  DT.120638478  DT.120638516  DT.97795023  DT.91739684  DT.91940806  DT.92036875 

    Selected AceView cDNA sequences (see all 102):

    BE502450 AV707525 BM973345 CR596296 BE073849 CB997993 AK055154 BM722981 
    AA514843 BQ011886 AA330436 BE672394 AA371262 BQ016671 BG033047 BX952767 
    AA370937 BX104931 AW005954 AL157483 BX399841 CA430596 BG572883 AK002126 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CSGALNACT1 (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d · 11e · 11f · 11g ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
    SP1:                    -     -     -     -                 -           -                                                                                 
    SP2:                                                        -     -     -                                                                                 
    SP3:                                                              -     -                                                                                 
    SP4:        -     -     -     -     -     -                 -     -     -                                                                                 
    SP5:              -     -     -     -     -                 -     -     -                                                                                 


    ECgene alternative splicing isoforms for CSGALNACT1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    CSGALNACT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CSGALNACT1 Expression
    About this image


    CSGALNACT1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Oligodendrocyte Precursor Cells Forebrain White Matter
             Cerebral Cortex
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             GABAergic Amacrine Cells Inner Nuclear Layer
             Lens
     
     Ovary (Reproductive System)
             Pre-Granulosa Cells Primordial Follicle
     
     Neural Crest (Gastrulation Derivatives)
             PureStem SM30, NCr-fac & Meso-latp Progenitor
     
     Neural Tube (Nervous System)
             Telencephalon
    CSGALNACT1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CSGALNACT1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.613729

    UniProtKB/Swiss-Prot: CGAT1_HUMAN, Q8TDX6
    Tissue specificity: Ubiquitous, with the highest levels in placenta, thyroid, bladder, prostate and adrenal gland.
    Detected at low levels in the other tissues examined

        Custom PCR Arrays for CSGALNACT1
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for CSGALNACT1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CSGALNACT1
    QuantiTect SYBR Green Assays in human, mouse, rat CSGALNACT1
    QuantiFast Probe-based Assays in human, mouse, rat CSGALNACT1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSGALNACT1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for CSGALNACT1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Csgalnact11 , 5 chondroitin sulfate N-acetylgalactosaminyltransferase more1, 5 85.69(n)1
    92.65(a)1
      8 (33.88 cM)5
    2343561  NM_001252623.11  NP_001239552.11 
     683567815 
    chicken
    (Gallus gallus)
    Aves CSGALNACT11 chondroitin sulfate N-acetylgalactosaminyltransferase more 75.47(n)
    79.96(a)
      422488  XM_420453.4  XP_420453.2 
    lizard
    (Anolis carolinensis)
    Reptilia CSGALNACT16
    chondroitin sulfate N-acetylgalactosaminyltransfer...
    79(a)
    1 ↔ 1
    6(58947871-58977097)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX750027.12   -- 77.74(n)    BX750027.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC7936711 chondroitin sulfate N-acetylgalactosaminyltransferase more 68.65(n)
    71.92(a)
      793671  XM_001333443.4  XP_001333479.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG129131 CG12913 51.84(n)
    45.37(a)
      36079  NM_136723.2  NP_610567.1 


    ENSEMBL Gene Tree for CSGALNACT1 (if available)
    TreeFam Gene Tree for CSGALNACT1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for CSGALNACT1 gene
    CHSY32  CHPF2  B4GALNT32  CSGALNACT22  CHSY12  CHPF22  B4GALNT42  
    2 SIMAP similar genes for CSGALNACT1 using alignment to 5 protein entries:     CGAT1_HUMAN (see all proteins):
    ChGn    CSGALNACT2

    Find genes that share paralogs with CSGALNACT1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for CSGALNACT1 (see all 8627)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1410720201,2
    --19261200(+) TCAAGA/CGATCC 3 -- int10--------
    rs624938521,2
    C,F--19261457(+) ACAATC/TTGATT 3 -- int12Minor allele frequency- T:0.04NA 122
    rs1872555051,2
    --19261537(+) CAGTAG/TAGAAG 3 -- int10--------
    rs1921095351,2
    --19261553(+) CCTCCA/CCAGCA 3 -- int10--------
    rs1479981031,2
    C--19261637(+) CAAAAA/GCTAAA 3 -- int10--------
    rs1419556841,2
    --19261690(+) TCATAC/TTTTAT 3 -- ut31 nc-transcript-variant0--------
    rs70012311,2
    C,F,A,H--19261730(+) GCCTGT/CGTTTT 3 -- ut31 nc-transcript-variantese314Minor allele frequency- C:0.05NS EA NA WA 2002
    rs786270471,2
    C,F--19261970(+) GTAATA/GAAATG 3 -- ut31 nc-transcript-variant1Minor allele frequency- G:0.02WA 118
    rs70055281,2
    C,F,H--19262106(+) ATGGAT/CTGATC 3 -- ut31 nc-transcript-variantese38Minor allele frequency- C:0.05NS EA NA 1092
    rs570825001,2
    C,F--19262135(+) TATATT/ATTTTT 3 -- ut31 nc-transcript-variant2Minor allele frequency- A:0.50WA 4

    HapMap Linkage Disequilibrium report for CSGALNACT1 (19261672 - 19511672 bp, first 250kb of CSGALNACT1)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CSGALNACT1 (see all 40):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv3485CNV Deletion18987735
    esv2736721CNV Deletion23290073
    esv2736724CNV Deletion23290073
    esv2736723CNV Deletion23290073
    esv2405754CNV Deletion18987734
    esv2736722CNV Deletion23290073
    esv2736728CNV Deletion23290073
    esv2736725CNV Deletion23290073
    esv2656596CNV Deletion23128226
    esv1000464CNV Deletion20482838

    Human Gene Mutation Database (HGMD): CSGALNACT1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CSGALNACT1
    DNA2.0 Custom Variant and Variant Library Synthesis for CSGALNACT1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    1 disease from the University of Copenhagen DISEASES database for CSGALNACT1:
    Glomerulonephritis

    Find genes that share disorders with CSGALNACT1           About GenesLikeMe

    Genetic Association Database (GAD): CSGALNACT1
    Human Genome Epidemiology (HuGE) Navigator: CSGALNACT1 (3 documents)

    Export disorders for CSGALNACT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CSGALNACT1 gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with CSGALNACT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Chondroitin sulfate N-acetylgalactosaminyltransferase-1 plays a critical role in chondroitin sulfate synthesis in cartilage. (PubMed id 17145758)1, 2, 3 Sakai K....Watanabe H. (J. Biol. Chem. 2007)
    2. Differential roles of two N-acetylgalactosaminyltransferases, CSGalNAcT-1, and a novel enzyme, CSGalNAcT-2. Initiation and elongation in synthesis of chondroitin sulfate. (PubMed id 12446672)1, 2, 3 Sato T.... Narimatsu H. (J. Biol. Chem. 2003)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors. (PubMed id 19730683)1, 4 Landa I....Robledo M. (PLoS Genet. 2009)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    8. Molecular cloning and expression of human chondroitin N- acetylgalactosaminyltransferase: key enzyme for chain initiation and elongation of chondroitin/dermatan sulfate on the protein linkage region tetrasaccharide shared by heparin/heparan sulfate. (PubMed id 11788602)1, 2 Uyama T.... Sugahara K. (J. Biol. Chem. 2002)
    9. Enzymatic synthesis of chondroitin with a novel chondroitin sulfate N-acetylgalactosaminyltransferase that transfers N-acetylgalactosamine to glucuronic acid in initiation and elongation of chondroitin sulfate synthesis. (PubMed id 12163485)1, 2 Gotoh M.... Narimatsu H. (J. Biol. Chem. 2002)
    10. A genome-wide association study of a sustained pattern of antidepressant response. (PubMed id 23726668)1 Hunter A.M....Hamilton S.P. (J Psychiatr Res 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 55790 HGNC: 24290 AceView: ChGn Ensembl:ENSG00000147408 euGenes: HUgn55790
    ECgene: CSGALNACT1 Kegg: 55790 H-InvDB: CSGALNACT1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CSGALNACT1 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=CSGALNACT1
    Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_477

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CSGALNACT1 gene:
    Search GeneIP for patents involving CSGALNACT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for CSGALNACT1   OriGene RNAi products in human, mouse, rat for CSGALNACT1  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for CSGALNACT1  
     OriGene qSTAR qPCR primer pairs in human, mouse for CSGALNACT1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for CSGALNACT1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CSGALNACT1   OriGene Custom Protein Services for CSGALNACT1  

     
     
     Block miRNA regulation of human, mouse, rat CSGALNACT1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CSGALNACT1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CSGALNACT1 Predesigned siRNA for gene silencing in human, mouse, rat CSGALNACT1
     QuantiFast Probe-based Assays in human, mouse, rat CSGALNACT1 QuantiTect SYBR Green Assays in human, mouse, rat CSGALNACT1
     Custom PCR Arrays for CSGALNACT1 Search Chromatin IP Primers for CSGALNACT1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CSGALNACT1  Search GeneGlobe Interaction Network for CSGALNACT1
     Regulatory tfbs in CSGALNACT1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for CSGALNACT1 GenScript cDNA clones with any tag delivered in your preferred vector for CSGALNACT1
     GenScript Custom Assay Services for CSGALNACT1 GenScript Custom overexpressing Cell Line Services for CSGALNACT1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for CSGALNACT1 (CGAT1)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CSGALNACT1 antibodies
     CSGALNACT1 proteins
     CSGALNACT1 lysates
     Antibodies for CSGALNACT1
     See all of Abcam's Antibodies, Kits and Proteins for CSGALNACT1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for CSGALNACT1
     Antibodies for CSGALNACT1
     ELISAs for CSGALNACT1
     CLIAs for CSGALNACT1



     Browse ESI BIO Cell Lines and PureStem Progenitors for CSGALNACT1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSGALNACT1
     SwitchGear 3'UTR luciferase reporter plasmids for CSGALNACT1
     SwitchGear Promoter luciferase reporter plasmids for CSGALNACT1
     ThermoFisher Antibodies for CSGALNACT1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSGALNACT1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CSGALNACT1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CSGALNACT1
     LSBio Antibodies in human, mouse, rat for CSGALNACT1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for CSGALNACT1
      Search eBioscience for proteins for CSGALNACT1
      Search eBioscience for elisas for CSGALNACT1
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CSGALNACT1 gene at Home site.
    Version: 3.12.202 14 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4