Aliases for CSGALNACT1 Gene
External Ids for CSGALNACT1 Gene
Previous GeneCards Identifiers for CSGALNACT1 Gene
GeneCards Summary for CSGALNACT1 Gene
CSGALNACT1 (Chondroitin Sulfate N-Acetylgalactosaminyltransferase 1) is a Protein Coding gene. Among its related pathways are Defective B4GALT7 causes EDS, progeroid type and dermatan sulfate biosynthesis. GO annotations related to this gene include glucuronosyltransferase activity and glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity. An important paralog of this gene is CSGALNACT2.
UniProtKB/Swiss-Prot for CSGALNACT1 Gene
Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains. Important role in chondroitin chain biosynthesis in cartilage formation and subsequent endochondral ossification (PubMed:11788602, PubMed:12163485, PubMed:12446672, PubMed:17145758). Moreover, is involved in the metabolism of aggrecan (By similarity).