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Aliases for CSF3 Gene

Aliases for CSF3 Gene

  • Colony Stimulating Factor 3 2 3 5
  • Pluripoietin 2 3 4
  • Lenograstim 2 3 4
  • Filgrastim 2 3 4
  • Colony Stimulating Factor 3 (Granulocyte) 2 3
  • C17orf33 3 4
  • GCSF 3 4
  • Granulocyte Colony Stimulating Factor 2
  • Granulocyte-Colony Stimulating Factor 3
  • Chromosome 17 Open Reading Frame 33 2
  • CSF3OS 3
  • G-CSF 4

External Ids for CSF3 Gene

Previous HGNC Symbols for CSF3 Gene

  • GCSF
  • G-CSF
  • C17orf33

Previous GeneCards Identifiers for CSF3 Gene

  • GC17M037625
  • GC17P040169
  • GC17P038081
  • GC17P038546
  • GC17P035425
  • GC17P038171
  • GC17P033965

Summaries for CSF3 Gene

Entrez Gene Summary for CSF3 Gene

  • The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes. The active protein is found extracellularly. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010]

GeneCards Summary for CSF3 Gene

CSF3 (Colony Stimulating Factor 3) is a Protein Coding gene. Diseases associated with CSF3 include neutropenia and aplastic anemia. Among its related pathways are Immune System and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include enzyme binding and growth factor activity.

UniProtKB/Swiss-Prot for CSF3 Gene

  • Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes.

Gene Wiki entry for CSF3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSF3 Gene

Genomics for CSF3 Gene

Regulatory Elements for CSF3 Gene

Transcription factor binding sites by QIAGEN in the CSF3 gene promoter:

Genomic Location for CSF3 Gene

Chromosome:
17
Start:
40,015,361 bp from pter
End:
40,017,813 bp from pter
Size:
2,453 bases
Orientation:
Plus strand

Genomic View for CSF3 Gene

Genes around CSF3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CSF3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CSF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSF3 Gene

Proteins for CSF3 Gene

  • Protein details for CSF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09919-CSF3_HUMAN
    Recommended name:
    Granulocyte colony-stimulating factor
    Protein Accession:
    P09919
    Secondary Accessions:
    • A8MXR7

    Protein attributes for CSF3 Gene

    Size:
    207 amino acids
    Molecular mass:
    22293 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for CSF3 Gene

    Alternative splice isoforms for CSF3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CSF3 Gene

Proteomics data for CSF3 Gene at MOPED

Post-translational modifications for CSF3 Gene

  • O-glycan consists of Gal-GalNAc disaccharide which can be modified with up to two sialic acid residues (done in recombinantly expressed G-CSF from CHO cells).
  • Glycosylation at Thr 166
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for CSF3 Gene

Domains & Families for CSF3 Gene

Gene Families for CSF3 Gene

Graphical View of Domain Structure for InterPro Entry

P09919

UniProtKB/Swiss-Prot:

CSF3_HUMAN :
  • Belongs to the IL-6 superfamily.
Family:
  • Belongs to the IL-6 superfamily.
genes like me logo Genes that share domains with CSF3: view

Function for CSF3 Gene

Molecular function for CSF3 Gene

GENATLAS Biochemistry:
colony-stimulating factor 3,22.3kDa,(granulocyte),playing a pivotal role in growth control of granulocytic progenitors,regulated by SPI1,MYB,others and inducing PRTN3 (see symbols),inducingJUNB and/or TOP in the proliferative response of human myeloidleukemia,putatively involved in severe congenital neutropenia
UniProtKB/Swiss-Prot Function:
Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes.

LifeMap Function Summary for CSF3 Gene

CSF3 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:

Gene Ontology (GO) - Molecular Function for CSF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005130 granulocyte colony-stimulating factor receptor binding TAS 2420009
genes like me logo Genes that share ontologies with CSF3: view
genes like me logo Genes that share phenotypes with CSF3: view

Animal Models for CSF3 Gene

MGI Knock Outs for CSF3:

Animal Model Products

  • Taconic Biosciences Mouse Models for CSF3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CSF3 Gene

Localization for CSF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSF3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CSF3 Gene COMPARTMENTS Subcellular localization image for CSF3 gene
Compartment Confidence
extracellular 5
cytosol 3
nucleus 3
cytoskeleton 2
lysosome 2
plasma membrane 2
vacuole 2
endosome 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for CSF3 Gene

Pathways & Interactions for CSF3 Gene

genes like me logo Genes that share pathways with CSF3: view

SIGNOR curated interactions for CSF3 Gene

Activates:

Gene Ontology (GO) - Biological Process for CSF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response IEA --
GO:0007275 multicellular organism development TAS 2420009
GO:0008284 positive regulation of cell proliferation IEA --
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IDA 23001182
GO:0019221 cytokine-mediated signaling pathway NAS 15664994
genes like me logo Genes that share ontologies with CSF3: view

Drugs & Compounds for CSF3 Gene

(71) Drugs for CSF3 Gene - From: Novoseek and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
TALABOSTAT Pharma 0

(53) Additional Compounds for CSF3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CSF3: view

Transcripts for CSF3 Gene

Unigene Clusters for CSF3 Gene

Colony stimulating factor 3 (granulocyte):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CSF3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d
SP1: - - -
SP2: - -
SP3: - - -
SP4: - - -
SP5: - - - -
SP6: - - - -
SP7:
SP8:
SP9: - - -

Relevant External Links for CSF3 Gene

GeneLoc Exon Structure for
CSF3
ECgene alternative splicing isoforms for
CSF3

Expression for CSF3 Gene

mRNA expression in normal human tissues for CSF3 Gene

mRNA differential expression in normal tissues according to GTEx for CSF3 Gene

This gene is overexpressed in Lung (x8.2), Heart - Atrial Appendage (x8.2), Adipose - Visceral (Omentum) (x4.3), and Muscle - Skeletal (x4.0).

SOURCE GeneReport for Unigene cluster for CSF3 Gene Hs.2233

genes like me logo Genes that share expression patterns with CSF3: view

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CSF3 Gene

Orthologs for CSF3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CSF3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CSF3 35
  • 97.1 (n)
  • 97.1 (a)
CSF3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CSF3 36
  • 82 (a)
OneToOne
CSF3 35
  • 85.98 (n)
  • 82.05 (a)
dog
(Canis familiaris)
Mammalia CSF3 35
  • 87.18 (n)
  • 81.54 (a)
CSF3 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Csf3 16
Csf3 36
  • 72 (a)
OneToOne
Csf3 35
  • 78.71 (n)
  • 74.26 (a)
oppossum
(Monodelphis domestica)
Mammalia CSF3 36
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CSF3 36
  • 59 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Csf3 35
  • 79.49 (n)
  • 75.9 (a)
chicken
(Gallus gallus)
Aves CSF3 35
  • 56.49 (n)
  • 40 (a)
CSF3 36
  • 37 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CSF3 36
  • 27 (a)
OneToOne
Species with no ortholog for CSF3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CSF3 Gene

ENSEMBL:
Gene Tree for CSF3 (if available)
TreeFam:
Gene Tree for CSF3 (if available)

Paralogs for CSF3 Gene

No data available for Paralogs for CSF3 Gene

Variants for CSF3 Gene

Sequence variations from dbSNP and Humsavar for CSF3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs2227329 - 40,016,804(+) AAGAA(A/C)TGGGA nc-transcript-variant, reference, missense
rs2227330 - 40,016,855(+) CCTTC(A/G)CCTCT nc-transcript-variant, reference, missense
rs2227315 -- 40,013,461(+) CAGTG(A/G)CTCAT upstream-variant-2KB
rs2227316 -- 40,013,754(+) CCCAC(C/T)CTCTA upstream-variant-2KB
rs2227317 -- 40,013,812(+) TGAGC(C/T)ACAGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CSF3 Gene

Variant ID Type Subtype PubMed ID
nsv908220 CNV Gain 21882294

Variation tolerance for CSF3 Gene

Residual Variation Intolerance Score: 79.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.89; 35.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CSF3 Gene

HapMap Linkage Disequilibrium report
CSF3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSF3 Gene

Disorders for CSF3 Gene

MalaCards: The human disease database

(71) MalaCards diseases for CSF3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
neutropenia
  • leukopenia
aplastic anemia
  • pulmonary fibrosis, idiopathic
severe congenital neutropenia
  • congenital agranulocytosis
pancytopenia
  • pancytopenia nos
refractory anemia with excess blasts in transformation
  • raeb-t
- elite association - COSMIC cancer census association via MalaCards
Search CSF3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CSF3

Genetic Association Database (GAD)
CSF3
Human Genome Epidemiology (HuGE) Navigator
CSF3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CSF3
genes like me logo Genes that share disorders with CSF3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CSF3 Gene

Publications for CSF3 Gene

  1. Association of genetic variations in the CSF2 and CSF3 genes with lung function in smoking-induced COPD. (PMID: 18353856) He J.Q. … Sandford A.J. (Eur. Respir. J. 2008) 3 48 67
  2. Complete sequencing of the recombinant granulocyte-colony stimulating factor (filgrastim) and detection of biotinylation by mass spectrometry. (PMID: 19526310) Ahmed K.E. … Lubec G. (Amino Acids 2010) 3 23
  3. G-CSF exerts dual effects on endothelial cells--opposing actions of direct eNOS induction versus indirect CRP elevation. (PMID: 18675273) Park K.W. … Kim H.S. (J. Mol. Cell. Cardiol. 2008) 3 23
  4. The granulocyte colony stimulating factor (G-CSF) activates Jak/STAT and MAPK pathways in a trophoblastic cell line. (PMID: 17879956) Marino V.J. … Roguin L.P. (J. Cell. Biochem. 2008) 3 23
  5. Elevated serum levels of human matrix metalloproteinase-9 (MMP-9) during the induction of peripheral blood stem cell mobilization by granulocyte colony-stimulating factor (G-CSF). (PMID: 18095095) Saito T. … Aiba K. (J. Infect. Chemother. 2007) 3 23

Products for CSF3 Gene

Sources for CSF3 Gene

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