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Aliases for CSF3 Gene

Aliases for CSF3 Gene

  • Colony Stimulating Factor 3 (Granulocyte) 2 3
  • Pluripoietin 2 3 4
  • Lenograstim 2 3 4
  • Filgrastim 2 3 4
  • GCSF 3 4 6
  • C17orf33 3 4
  • Granulocyte Colony Stimulating Factor 2
  • Granulocyte Colony-Stimulating Factor 3
  • Granulocyte-Colony Stimulating Factor 3
  • Chromosome 17 Open Reading Frame 33 2
  • CSF3OS 3
  • G-CSF 4

External Ids for CSF3 Gene

Previous HGNC Symbols for CSF3 Gene

  • GCSF
  • G-CSF
  • C17orf33

Previous GeneCards Identifiers for CSF3 Gene

  • GC17M037625
  • GC17P040169
  • GC17P038081
  • GC17P038546
  • GC17P035425
  • GC17P038171
  • GC17P033965

Summaries for CSF3 Gene

Entrez Gene Summary for CSF3 Gene

  • The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes. The active protein is found extracellularly. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010]

GeneCards Summary for CSF3 Gene

CSF3 (Colony Stimulating Factor 3 (Granulocyte)) is a Protein Coding gene. Diseases associated with CSF3 include refractory anemia with excess blasts in transformation and adult lymphoma. Among its related pathways are PI3K-Akt signaling pathway and Akt Signaling. GO annotations related to this gene include enzyme binding and growth factor activity.

UniProtKB/Swiss-Prot for CSF3 Gene

  • Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes

Gene Wiki entry for CSF3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSF3 Gene

Genomics for CSF3 Gene

Regulatory Elements for CSF3 Gene

Transcription factor binding sites by QIAGEN in the CSF3 gene promoter:

Genomic Location for CSF3 Gene

Start:
40,015,361 bp from pter
End:
40,017,813 bp from pter
Size:
2,453 bases
Orientation:
Plus strand

Genomic View for CSF3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CSF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSF3 Gene

Proteins for CSF3 Gene

  • Protein details for CSF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09919-CSF3_HUMAN
    Recommended name:
    Granulocyte colony-stimulating factor
    Protein Accession:
    P09919
    Secondary Accessions:
    • A8MXR7

    Protein attributes for CSF3 Gene

    Size:
    207 amino acids
    Molecular mass:
    22293 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for CSF3 Gene

    Alternative splice isoforms for CSF3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CSF3 Gene

Proteomics data for CSF3 Gene at MOPED

Post-translational modifications for CSF3 Gene

  • O-glycan consists of Gal-GalNAc disaccharide which can be modified with up to two sialic acid residues (done in recombinantly expressed G-CSF from CHO cells)
  • Glycosylation at Thr166
  • Modification sites at PhosphoSitePlus

Antibody Products

Protein Products

No data available for DME Specific Peptides for CSF3 Gene

Domains for CSF3 Gene

Gene Families for CSF3 Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

P09919

UniProtKB/Swiss-Prot:

CSF3_HUMAN :
  • P09919
Family:
  • Belongs to the IL-6 superfamily.
genes like me logo Genes that share domains with CSF3: view

Function for CSF3 Gene

Molecular function for CSF3 Gene

GENATLAS Biochemistry:
colony-stimulating factor 3,22.3kDa,(granulocyte),playing a pivotal role in growth control of granulocytic progenitors,regulated by SPI1,MYB,others and inducing PRTN3 (see symbols),inducingJUNB and/or TOP in the proliferative response of human myeloidleukemia,putatively involved in severe congenital neutropenia
UniProtKB/Swiss-Prot Function:
Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes

LifeMap Function Summary for CSF3 Gene

CSF3 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:

Gene Ontology (GO) - Molecular Function for CSF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity NAS 15664994
GO:0005130 granulocyte colony-stimulating factor receptor binding TAS 2420009
GO:0008083 growth factor activity IEA --
GO:0019899 enzyme binding IPI 12393522
genes like me logo Genes that share ontologies with CSF3: view
genes like me logo Genes that share phenotypes with CSF3: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CSF3 Gene

Localization for CSF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSF3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CSF3 Gene COMPARTMENTS Subcellular localization image for CSF3 gene
Compartment Confidence
extracellular 5
cytosol 1
nucleus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CSF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with CSF3: view

Pathways for CSF3 Gene

genes like me logo Genes that share pathways with CSF3: view

PCR Array Products

Gene Ontology (GO) - Biological Process for CSF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response IEA --
GO:0007275 multicellular organismal development TAS 2420009
GO:0008284 positive regulation of cell proliferation IEA --
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IDA 23001182
GO:0019221 cytokine-mediated signaling pathway NAS 15664994
genes like me logo Genes that share ontologies with CSF3: view

Compounds for CSF3 Gene

UniProtKB/Swiss-Prot:

P09919-CSF3_HUMAN
Pharmaceutical: Available under the names Neupogen or Granulokine (Amgen/Roche) and Granocyte (Rhone-Poulenc). Used to treat neutropenia (a disorder characterized by an extremely low number of neutrophils in blood)

(123) Novoseek inferred chemical compound relationships for CSF3 Gene

Compound -log(P) Hits PubMed IDs
filgrastim 96 328
lenograstim 90 91
cyclophosphamide 87.7 253
pegfilgrastim 85.1 87
etoposide 84 184
genes like me logo Genes that share compounds with CSF3: view

Transcripts for CSF3 Gene

Unigene Clusters for CSF3 Gene

Colony stimulating factor 3 (granulocyte):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CSF3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CSF3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d
SP1: - - -
SP2: - -
SP3: - - -
SP4: - - -
SP5: - - - -
SP6: - - - -
SP7:
SP8:
SP9: - - -

Relevant External Links for CSF3 Gene

GeneLoc Exon Structure for
CSF3
ECgene alternative splicing isoforms for
CSF3

Expression for CSF3 Gene

mRNA expression in normal human tissues for CSF3 Gene

mRNA differential expression in normal tissues according to GTEx for CSF3 Gene

This gene is overexpressed in Lung (8.2), Heart - Atrial Appendage (8.2), Adipose - Visceral (Omentum) (4.3), and Muscle - Skeletal (4.0).

SOURCE GeneReport for Unigene cluster for CSF3 Gene Hs.2233

genes like me logo Genes that share expressions with CSF3: view

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for CSF3 Gene

Orthologs for CSF3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CSF3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CSF3 35
  • 85.98 (n)
  • 82.05 (a)
CSF3 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CSF3 35
  • 87.18 (n)
  • 81.54 (a)
CSF3 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Csf3 35
  • 78.71 (n)
  • 74.26 (a)
Csf3 16
Csf3 36
  • 72 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CSF3 35
  • 97.1 (n)
  • 97.1 (a)
CSF3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Csf3 35
  • 79.49 (n)
  • 75.9 (a)
oppossum
(Monodelphis domestica)
Mammalia CSF3 36
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CSF3 36
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves CSF3 35
  • 56.49 (n)
  • 40 (a)
CSF3 36
  • 37 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CSF3 36
  • 27 (a)
OneToOne
Species with no ortholog for CSF3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CSF3 Gene

ENSEMBL:
Gene Tree for CSF3 (if available)
TreeFam:
Gene Tree for CSF3 (if available)

Paralogs for CSF3 Gene

No data available for Paralogs for CSF3 Gene

Variants for CSF3 Gene

Sequence variations from dbSNP and Humsavar for CSF3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs2827 -- 40,017,484(+) AATCT(C/T)GTTTT utr-variant-3-prime, nc-transcript-variant
rs25645 -- 40,016,890(+) GTCCT(A/G)GTTGC synonymous-codon, reference, nc-transcript-variant
rs1042657 -- 40,017,539(+) CGACG(C/T)GTCTC utr-variant-3-prime, nc-transcript-variant
rs1042658 -- 40,017,649(+) CTGGA(C/T)GGGGA utr-variant-3-prime, nc-transcript-variant
rs2071369 -- 40,016,052(+) GGCAT(C/T)ACATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CSF3 Gene

Variant ID Type Subtype PubMed ID
nsv908220 CNV Gain 21882294

Relevant External Links for CSF3 Gene

HapMap Linkage Disequilibrium report
CSF3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSF3 Gene

Disorders for CSF3 Gene

(88) Novoseek inferred disease relationships for CSF3 Gene

Disease -log(P) Hits PubMed IDs
neutropenia 95 333
neutropenia, severe congenital 88.5 44
agranulocytosis 86.2 168
myelodysplastic syndromes 82.7 123
neutropenia cyclic 81.8 55

Relevant External Links for CSF3

Genetic Association Database (GAD)
CSF3
Human Genome Epidemiology (HuGE) Navigator
CSF3
genes like me logo Genes that share disorders with CSF3: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for CSF3 Gene

Publications for CSF3 Gene

  1. Homodimeric cross-over structure of the human granulocyte colony- stimulating factor (GCSF) receptor signaling complex. (PMID: 16492764) Tamada T. … Kuroki R. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3 4 23
  2. Granulocyte colony-stimulating factor receptor signals for beta1-integrin expression and adhesion in bladder cancer. (PMID: 14751388) Chakraborty A. … Lerner S.P. (Urology 2004) 3 23
  3. Antiapoptotic effect of granulocyte colony-stimulating factor, granulocyte-macrophage colony-stimulating factor, and cyclic AMP on human neutrophils: protein synthesis-dependent and protein synthesis-independent mechanisms and the role of the Janus kinase-STAT pathway. (PMID: 12568301) Sakamoto C. … Kitagawa S. (Int. J. Hematol. 2003) 3 23
  4. Endogenous granulocyte colony-stimulating factor (G-CSF) levels in chemotherapy-induced neutropenia and in neutropenia related with primary diseases. (PMID: 12636092) Kavgaci H. … Yavuz M. (J. Exp. Clin. Cancer Res. 2002) 3 23
  5. Endogenous G-CSF and CD34+ cell mobilization after acute myocardial infarction. (PMID: 16051386) Leone A.M. … Crea F. (Int. J. Cardiol. 2006) 3 23

Products for CSF3 Gene

Sources for CSF3 Gene

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