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CSF3 Gene

protein-coding   GIFtS: 65
GCID: GC17P038171

Colony Stimulating Factor 3 (Granulocyte)

(Previous name: chromosome 17 open reading frame 33)
(Previous symbols: GCSF, G-CSF, C17orf33)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Colony Stimulating Factor 3 (Granulocyte)1 2     Chromosome 17 Open Reading Frame 331
GCSF1 2 3 5     Granulocyte Colony Stimulating Factor1
C17orf331 2 3     CSF3OS2
G-CSF1 3     Granulocyte Colony-Stimulating Factor2
filgrastim1 2     Filgrastim3
lenograstim1 2     Lenograstim3
pluripoietin1 2     Pluripoietin3

External Ids:    HGNC: 24381   Entrez Gene: 14402   Ensembl: ENSG000001083427   OMIM: 1389705   UniProtKB: P099193   

Export aliases for CSF3 gene to outside databases

Previous GC identifers: GC17M037625 GC17P040169 GC17P038081 GC17P038546 GC17P035425 GC17P033965


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CSF3 Gene:
The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of
granulocytes. The active protein is found extracellularly. Alternatively spliced transcript variants have been
described for this gene. (provided by RefSeq, May 2010)

GeneCards Summary for CSF3 Gene:
CSF3 (colony stimulating factor 3 (granulocyte)) is a protein-coding gene. Diseases associated with CSF3 include lung large cell carcinoma, and refractory anemia with excess blasts in transformation. GO annotations related to this gene include growth factor activity and enzyme binding.

UniProtKB/Swiss-Prot: CSF3_HUMAN, P09919
Function: Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling
the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes
and the monocytes-macrophages. This CSF induces granulocytes

Gene Wiki entry for CSF3 (Granulocyte colony-stimulating factor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the CSF3 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CSF3 promoter sequence
   Search Chromatin IP Primers for CSF3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CSF3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2-q12   Ensembl cytogenetic band:  17q21.1   HGNC cytogenetic band: 17q11.2-q12

CSF3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CSF3 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P038171:  view genomic region     (about GC identifiers)

Start:
38,171,614 bp from pter      End:
38,174,066 bp from pter
Size:
2,453 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CSF3_HUMAN, P09919 (See protein sequence)
Recommended Name: Granulocyte colony-stimulating factor precursor  
Size: 207 amino acids; 22293 Da
Subunit: Monomer
Caution: PubMed:2420009 misquotes the gene name as "CSF1"
5 PDB 3D structures from and Proteopedia for CSF3:
1CD9 (3D)        1GNC (3D)        1PGR (3D)        1RHG (3D)        2D9Q (3D)    
Secondary accessions: A8MXR7
Alternative splicing: 3 isoforms:  P09919-1   P09919-2   P09919-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CSF3: NX_P09919

Explore proteomics data for CSF3 at MOPED

Post-translational modifications: 

  • O-glycan consists of Gal-GalNAc disaccharide which can be modified with up to two sialic acid residues (done in
    recombinantly expressed G-CSF from CHO cells)1
  • Glycosylation2 at Thr166
  • Modification sites at PhosphoSitePlus

  • See CSF3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_000750.1  NP_001171618.1  NP_757373.1  NP_757374.2  

    ENSEMBL proteins: 
     ENSP00000464421   ENSP00000377705   ENSP00000225474   ENSP00000464157   ENSP00000327766  
     ENSP00000377704   ENSP00000462991  

    CSF3 Human Recombinant Protein Products:

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    Enzo Life Sciences proteins for CSF3
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    OriGene Protein Over-expression Lysate for CSF3
    OriGene MassSpec for CSF3
    OriGene Custom Protein Services for CSF3
    GenScript Custom Purified and Recombinant Proteins Services for CSF3
    Novus Biologicals CSF3 Proteins
    Novus Biologicals CSF3 Lysates
    Sino Biological Recombinant Protein for CSF3
    Sino Biological Cell Lysate for CSF3
    ProSpec Recombinant Protein for CSF3
    Browse Proteins at Cloud-Clone Corp.

    CSF3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CSF3 (G-CSF)
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    Novus Biologicals CSF3 Antibodies
    Abcam antibodies for CSF3
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for CSF3
    LSBio Antibodies in human, mouse, rat for CSF3

    CSF3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CSF3
    R&D Systems ELISAs for CSF3 (G-CSF)         (see all)
    GenScript Custom Assay Services for CSF3
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands

    3 InterPro protein domains:
     IPR012351 4_helix_cytokine_core
     IPR009079 4_helix_cytokine-like_core
     IPR003573 IL-6/IL-23/GCSF/MGF

    Graphical View of Domain Structure for InterPro Entry P09919

    ProtoNet protein and cluster: P09919

    1 Blocks protein domain: IPB003629 Granulocyte colony-stimulating/myelomonocytic growth factor

    UniProtKB/Swiss-Prot: CSF3_HUMAN, P09919
    Similarity: Belongs to the IL-6 superfamily


    CSF3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CSF3_HUMAN, P09919
    Function: Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling
    the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes
    and the monocytes-macrophages. This CSF induces granulocytes

         Genatlas biochemistry entry for CSF3:
    colony-stimulating factor 3,22.3kDa,(granulocyte),playing a pivotal role in growth control of granulocytic
    progenitors,regulated by SPI1,MYB,others and inducing PRTN3 (see symbols),inducingJUNB and/or TOP in the
    proliferative response of human myeloidleukemia,putatively involved in severe congenital neutropenia

         Summary: 
    CSF3 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
                
    Blood: Granulocytes-like cells, Granulocytes-like cells

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity NAS15664994
    GO:0005130granulocyte colony-stimulating factor receptor binding TAS2420009
    GO:0008083growth factor activity IEA--
    GO:0019899enzyme binding IPI12393522
         
    CSF3 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Csf3):
     hematopoietic system  immune system  integument  renal/urinary system 

    CSF3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CSF3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CSF3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CSF3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CSF3

    miRNA
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    Block miRNA regulation of human, mouse, rat CSF3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CSF3 (see all 14):
    hsa-miR-30c-2* hsa-miR-577 hsa-miR-2110 hsa-miR-200a hsa-miR-548v hsa-miR-662 hsa-miR-141 hsa-miR-890
    SwitchGear 3'UTR luciferase reporter plasmidCSF3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CSF3
    Predesigned siRNA for gene silencing in human, mouse, rat CSF3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CSF3

    Clone
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    OriGene clones in human, mouse for CSF3 (see all 20)
    OriGene ORF clones in mouse, rat for CSF3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): CSF3 (NM_000759)
    Sino Biological Human cDNA Clone for CSF3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CSF3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSF3

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CSF3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSF3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CSF3_HUMAN, P09919: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytosol1
    nucleus1
    vacuole1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space IEA--

    CSF3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CSF3 About   (see all 10)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Regulation of Innate Immune Cells0.94
    IL-6 Pathway0.61
    MIF Mediated Glucocorticoid Regulation0.94
    STAT3 Pathway0.47
    PEDF Induced Signaling0.73
    Endothelin-1 Signaling Pathway0.46
    all-trans-Retinoic Acid Signaling in Brain0.71
    Cytokine-cytokine receptor interaction0.43
    2ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    3Cytokine production by Th17 cells in CF
    Cytokine production by Th17 cells in CF0.72
    Cytokine production by Th17 cells in CF Mouse model 0.72
    4Akt Signaling
    Akt Signaling0.60
    p38 Signaling0.60
    5PAK Pathway
    PAK Pathway0.56
    Antioxidant Action of Vitamin-C0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CSF3 (see all 15)
        MIF Regulation of Innate Immune Cells
    STAT3 Pathway
    Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C

    2 GeneGo (Thomson Reuters) Pathways for CSF3
        Cytokine production by Th17 cells in CF (Mouse model)
    Cytokine production by Th17 cells in CF

    1 BioSystems Pathway for CSF3
        Cytokines and Inflammatory Response



    5 Kegg Pathways  (Kegg details for CSF3):
        Cytokine-cytokine receptor interaction
    PI3K-Akt signaling pathway
    Jak-STAT signaling pathway
    Hematopoietic cell lineage
    Malaria


    CSF3 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CSF3 (see all 19): 
              Lung Cancer in human mouse rat
              Interferons & Receptors in human mouse rat
              Wound Healing in human mouse rat
              Lymphoma in human mouse rat
              Th17 Response in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CSF3

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for CSF3 (P099193 ENSP000002254744) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ELANEP082463, ENSP000002636214I2D: score=1 STRING: ENSP00000263621
    CSF3RQ990623I2D: score=1 
    --ENSP000003426234STRING: ENSP00000342623
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response IEA--
    GO:0007275multicellular organismal development TAS2420009
    GO:0008284positive regulation of cell proliferation IEA--
    GO:0014068positive regulation of phosphatidylinositol 3-kinase signaling IDA--
    GO:0019221cytokine-mediated signaling pathway NAS15664994

    CSF3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CSF3

    UniProtKB/Swiss-Prot: CSF3_HUMAN, P09919
    Pharmaceutical: Available under the names Neupogen or Granulokine (Amgen/Roche) and Granocyte (Rhone-Poulenc).
    Used to treat neutropenia (a disorder characterized by an extremely low number of neutrophils in blood)

    Selected Novoseek inferred chemical compound relationships for CSF3 gene (see all 123)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    filgrastim 96 1102 11098978 (10), 19840722 (8), 10592434 (7), 9619915 (7) (see all 99)
    lenograstim 90 116 9951685 (3), 7512258 (2), 12629058 (2), 12352049 (2) (see all 84)
    cyclophosphamide 87.7 1090 9543059 (9), 15829405 (6), 8558227 (6), 11346706 (4) (see all 99)
    pegfilgrastim 85.1 126 19076208 (7), 16982322 (5), 17064993 (4), 19308043 (4) (see all 56)
    etoposide 84 450 8946866 (4), 7595759 (4), 9764585 (4), 10595815 (4) (see all 99)
    cytarabine 83.6 342 7507264 (3), 8926688 (3), 9364868 (3), 8819077 (3) (see all 99)
    plerixafor 82.6 185 19135941 (4), 19167685 (4), 20009003 (4), 19363221 (3) (see all 25)
    ifosfamide 81.3 189 8946866 (4), 8610230 (3), 14586157 (3), 11127946 (3) (see all 99)
    carboplatin 78.4 183 11127946 (4), 8826913 (3), 14632773 (3), 16781005 (3) (see all 96)
    paclitaxel 78.4 532 7509652 (9), 7692001 (6), 8558227 (6), 7509380 (6) (see all 99)



    CSF3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CSF3 gene (4 alternative transcripts): 
    NM_000759.3  NM_001178147.1  NM_172219.2  NM_172220.2  

    Unigene Cluster for CSF3:

    Colony stimulating factor 3 (granulocyte)
    Hs.2233  [show with all ESTs]
    Unigene Representative Sequence: NR_033662
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000583218 ENST00000394149(uc002htp.3 uc002hto.3 uc021tww.1 uc021twx.1)
    ENST00000582798 ENST00000225474 ENST00000579852 ENST00000479880 ENST00000331769(uc002htq.3 uc010wep.2)
    ENST00000394148 ENST00000577675
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CSF3 (see all 14):
    hsa-miR-30c-2* hsa-miR-577 hsa-miR-2110 hsa-miR-200a hsa-miR-548v hsa-miR-662 hsa-miR-141 hsa-miR-890
    SwitchGear 3'UTR luciferase reporter plasmidCSF3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CSF3
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    OriGene ORF clones in mouse, rat for CSF3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): CSF3 (NM_000759)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CSF3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSF3
    Primer
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    OriGene qPCR primer pairs and template standards for CSF3
    OriGene qSTAR qPCR primer pairs in human, mouse for CSF3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CSF3
      QuantiTect SYBR Green Assays in human, mouse, rat CSF3
      QuantiFast Probe-based Assays in human, mouse, rat CSF3

    Additional mRNA sequence: 

    AB102881.1 AK290247.1 AK298116.1 AK313509.1 BC033245.1 CR541891.1 HM132049.1 M17706.1 
    NR_033662.1 X03438.1 X03655.1 

    5 DOTS entries:

    DT.97840643  DT.100022617  DT.120892152  DT.91702158  DT.99933476 

    Selected AceView cDNA sequences (see all 44):

    NM_172220 BI822673 BM906367 CD013925 BM554035 CB136760 BM553432 CD013926 
    NM_172219 CD370607 X03438 CD013924 NM_000759 CB126975 CD370654 BX108471 
    BM915836 M17706 BM423896 BM923410 BG548320 X03655 CA307647 BM906188 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CSF3 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d
    SP1:                                -     -     -                                       
    SP2:                                      -     -                                       
    SP3:                                      -     -     -                                 
    SP4:                                -     -     -                                       
    SP5:                                -     -     -     -                                 


    ECgene alternative splicing isoforms for CSF3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CSF3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAGGCCTGT
    CSF3 Expression
    About this image


    CSF3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Bone marrow-derived mesenchymal stem cells
     
     Mesenchymal Stem Cells
             Bone marrow-derived mesenchymal stem cells
     
     NULL (Uncategorized)    fully expand to see all 2 entries
             Adipose-derived stromal vascular fraction and adipocytes (HiQCell)
             SKIN   
     
     Smooth Muscle (Muscoskeletal System)

     --
             SKIN   
    CSF3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CSF3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.2233
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CSF3 (see all 19): 
              Lung Cancer in human mouse rat
              Interferons & Receptors in human mouse rat
              Wound Healing in human mouse rat
              Lymphoma in human mouse rat
              Th17 Response in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CSF3
    OriGene qSTAR qPCR primer pairs in human, mouse for CSF3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CSF3
    QuantiTect SYBR Green Assays in human, mouse, rat CSF3
    QuantiFast Probe-based Assays in human, mouse, rat CSF3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSF3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CSF3 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Csf31 , 5 colony stimulating factor 3 (granulocyte)1, 5 78.71(n)1
    74.26(a)1
      11 (62.45 cM)5
    129851  NM_009971.11  NP_034101.11 
     987012635 
    chicken
    (Gallus gallus)
    Aves CSF31 colony stimulating factor 3 (granulocyte) 56.49(n)
    40(a)
      396216  NM_205279.1  NP_990610.1 
    lizard
    (Anolis carolinensis)
    Reptilia CSF36
    colony stimulating factor 3 (granulocyte)
    27(a)
    1 ↔ 1
    6(68967305-68982430)


    ENSEMBL Gene Tree for CSF3 (if available)
    TreeFam Gene Tree for CSF3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CSF3 (see all 135)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1413552161,2
    --38169645(+) AACATA/GTTTAA 5 -- us2k10--------
    rs116558211,2
    C,F,H--38169694(+) CCCACC/TCTCAA 5 -- us2k110Minor allele frequency- T:0.07NS EA NA WA 1208
    rs1474243321,2
    C--38169701(+) TCAAGA/GCCAGG 5 -- us2k10--------
    rs126029581,2
    C,H--38169708(+) CAGGTG/ACAGTG 5 -- us2k12Minor allele frequency- A:0.09NA EA 122
    rs22273151,2
    C,F,A,H--38169714(+) CAGTGG/ACTCAT 5 -- us2k18Minor allele frequency- A:0.44NS NA WA 100
    rs1865443771,2
    --38169800(+) ACCAAA/CATGGT 5 -- us2k10--------
    rs1913545121,2
    --38169893(+) GCAGGA/GAAATC 5 -- us2k10--------
    rs22273161,2
    C,F,A--38170007(+) CCCACC/TCTCTA 5 -- us2k18Minor allele frequency- T:0.29NS WA NA CSA 328
    rs1436159441,2
    --38170015(+) CTACTC/GCCAGG 5 -- us2k10--------
    rs22273171,2
    C,F--38170065(+) TGAGCC/TACAGA 5 -- us2k15Minor allele frequency- T:0.06NS NA WA 202

    HapMap Linkage Disequilibrium report for CSF3 (38171614 - 38174066 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CSF3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv908220CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CSF3
    DNA2.0 Custom Variant and Variant Library Synthesis for CSF3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 138970    OMIM disorders: --

    Selected diseases for CSF3 (see all 330):    
    About MalaCards
    lung large cell carcinoma    refractory anemia with excess blasts in transformation    adult lymphoma    colchicine poisoning
    cytophagic histiocytic panniculitis    ogilvie syndrome    cyclic hematopoiesis    gastric adenosquamous carcinoma
    zygomycosis    ascending colon cancer    pyomyositis    lung sarcoma
    virus associated hemophagocytic syndrome    aortitis    bone marrow necrosis    glycogen storage disease type 1b
    acute febrile neutrophilic dermatosis    trichosporonosis    engraftment syndrome    localized osteosarcoma

    8 diseases from the University of Copenhagen DISEASES database for CSF3:
    Neutropenia     Thrombocytopenia     Lymphoma     Leukemia
    Breast cancer     Multiple myeloma     Anemia     Lung cancer

    CSF3 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for CSF3 gene (see all 88)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neutropenia 95 1784 17402806 (9), 12636092 (6), 1711156 (6), 10887102 (6) (see all 99)
    neutropenia, severe congenital 88.5 62 7539627 (2), 11146160 (2), 17311988 (2), 16500901 (2) (see all 38)
    agranulocytosis 86.2 285 15644577 (6), 9292945 (5), 18181220 (5), 7679571 (5) (see all 99)
    myelodysplastic syndromes 82.7 194 19564636 (2), 9364865 (2), 7512125 (2), 7531261 (2) (see all 99)
    neutropenia cyclic 81.8 70 7544058 (3), 9252852 (3), 1692489 (2), 7532983 (2) (see all 42)
    leukopenia 81.7 232 9885374 (6), 9072843 (5), 17726809 (4), 19486571 (4) (see all 99)
    thrombocytopenia 81.1 118 17207228 (5), 17034024 (4), 9293906 (3), 8946866 (2) (see all 91)
    anemia aplastic 81 194 7540227 (4), 8587170 (3), 10629575 (3), 7504333 (3) (see all 99)
    kostmanns syndrome 80.8 17 11533372 (3), 12489493 (2), 7531241 (1), 7514821 (1) (see all 11)
    lymphoma non-hodgkins 78.8 342 19233728 (4), 8908287 (3), 11920216 (3), 12629058 (2) (see all 99)

    Genetic Association Database (GAD): CSF3
    Human Genome Epidemiology (HuGE) Navigator: CSF3 (35 documents)

    Export disorders for CSF3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CSF3 gene, integrated from 10 sources (see all 4742):
    (articles sorted by number of sources associating them with CSF3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association of genetic variations in the CSF2 and CSF3 genes with lung function in smoking-induced COPD. (PubMed id 18353856)1, 4, 9 He J.Q....Sandford A.J. (Eur. Respir. J. 2008)
    2. Homodimeric cross-over structure of the human granulocyte colony- stimulating factor (GCSF) receptor signaling complex. (PubMed id 16492764)1, 2, 9 Tamada T....Kuroki R. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    3. Common variations in PSMD3-CSF3 and PLCB4 are associated with neutrophil count. (PubMed id 20172861)1, 4 Okada Y....Kamatani N. (Hum. Mol. Genet. 2010)
    4. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)
    5. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
    6. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    7. A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM). (PubMed id 20673868)1, 4 Romero R....Menon R. (Am. J. Obstet. Gynecol. 2010)
    8. The IFNG (IFN-gamma) genotype predicts cytogenetic and molecular response to imatinib therapy in chronic myeloid leukemia. (PubMed id 20959405)1, 4 Kim D.H....Lipton J.H. (Clin. Cancer Res. 2010)
    9. Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population. (PubMed id 20485444)1, 4 Wang Y....Huang W. (J. Hum. Genet. 2010)
    10. Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. (PubMed id 20452482)1, 4 Romero R....Menon R. (Am. J. Obstet. Gynecol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1440 HGNC: 2438 AceView: CSF3 Ensembl:ENSG00000108342 euGenes: HUgn1440
    ECgene: CSF3 Kegg: 1440 H-InvDB: CSF3

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CSF3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CSF3 Genetics and Cytogenetics in Oncology and Haematology
    Neupogen/Granulokinehttp://www.neupogen.com/pi.html
    SeattleSNPshttp://pga.gs.washington.edu/data/csf3/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CSF3 gene:
    Search GeneIP for patents involving CSF3

    Licensable Technologies for CSF3 gene:
    Weizmann Institute:Novel treatment for improving bone-marrow transplantation success
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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