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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CSF3 Gene

protein-coding GIFtS: 66
GCID: GC17P038171

colony stimulating factor 3 (granulocyte)

(Previous name: chromosome 17 open reading frame 33 )
(Previous symbols: GCSF, G-CSF, C17orf33)

Explore 344 diseases affiliated with
CSF3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Colony Stimulating Factor 3 (Granulocyte)¹ ²		Filgrastim³
GCSF¹ ² ³ ⁵		Granulocyte Colony-Stimulating Factor²
C17orf33¹ ² ³		Lenograstim³
G-CSF¹ ³		Pluripoietin³
MGC45931¹		Filgrastim³
Chromosome 17 Open Reading Frame 33¹		Lenograstim³
CSF3OS²		Pluripoietin³

External Ids:	HGNC: 2438¹	Entrez Gene: 1440²	Ensembl: ENSG00000108342⁷	OMIM: 138970⁵	UniProtKB: P09919³

ORGUL members:
	NONCODE:n409309

Export aliases for CSF3 gene to outside databases

Previous GC identifers: GC17M037625 GC17P040169 GC17P038081 GC17P038546 GC17P035425 GC17P033965

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CSF3:

The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of

granulocytes. The active protein is found extracellularly. Alternatively spliced transcript variants have been

described for this gene. (provided by RefSeq, May 2010)

UniProtKB/Swiss-Prot: CSF3_HUMAN, P09919

Function: Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the

production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the

monocytes-macrophages. This CSF induces granulocytes

Gene Wiki entry for CSF3 (Granulocyte colony-stimulating factor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010783.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CSF3 gene promoter:
AML1a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CSF3 promoter sequence

Search SABiosciences Chromatin IP Primers for CSF3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CSF3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2-q12 Ensembl cytogenetic band: 17q21.1 HGNC cytogenetic band: 17q11.2-q12

CSF3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CSF3 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P038171: view genomic region (about GC identifiers)

Start:	38,171,614 bp from pter	End:	38,174,066 bp from pter
Size:	2,453 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CSF3_HUMAN, P09919 (See protein sequence)

Recommended Name: Granulocyte colony-stimulating factor precursor

Size: 207 amino acids; 22293 Da

Subunit: Monomer

Subcellular location: Secreted

Caution: PubMed:2420009 misquotes the gene name as "CSF1"

5 PDB 3D structures from and Proteopedia for CSF3:

1CD9 (3D)

1GNC (3D)

1PGR (3D)

1RHG (3D)

2D9Q (3D)

Secondary accessions: A8MXR7

Alternative splicing: 3 isoforms: P09919-1 P09919-2 P09919-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CSF3: NX_P09919

Post-translational modifications:

O-glycan consists of Gal-GalNAc disaccharide which can be modified with up to two sialic acid residues (done in

recombinantly expressed G-CSF from CHO cells)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P09919

CSF3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_000750.1 NP_001171618.1 NP_757373.1 NP_757374.2

ENSEMBL proteins:

ENSP00000464421 ENSP00000377705 ENSP00000225474 ENSP00000464157 ENSP00000327766

ENSP00000377704 ENSP00000462991

Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant CSF3 Protein
	R&D Systems Recombinant & Natural Proteins for CSF3 (G-CSF)
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	OriGene Purified Proteins (see all 2): CSF3 OriGene Protein Over-expression Lysate (see all 3): CSF3 OriGene Custom Protein Services for CSF3
	GenScript Custom Purified and Recombinant Proteins Services for CSF3
	Novus Biologicals CSF3 Proteins Novus Biologicals CSF3 Lysates
	Sino Biological Recombinant Protein for CSF3
	ProSpec Recombinant Protein for CSF3
	Uscn Proteins for CSF3

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	--	--
GO:0005615	extracellular space	IEA	--

CSF3 for ontologies About GeneDecksing

CSF3 Antibody Products:

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	Uscn Antibodies for CSF3
	ThermoFisher Antibodies for CSF3

Assay Products for CSF3:

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	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CSF3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CSF3 for domains About GeneDecksing

3 InterPro domains/families:

IPR012351 4_helix_cytokine_core

IPR009079 4_helix_cytokine-like_core

IPR003573 IL6_MGF_GCSF

Graphical View of Domain Structure for InterPro Entry P09919

ProtoNet protein and cluster: P09919

1 Blocks protein family: IPB003629 Granulocyte colony-stimulating/myelomonocytic growth factor

UniProtKB/Swiss-Prot: CSF3_HUMAN, P09919

Similarity: Belongs to the IL-6 superfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CSF3_HUMAN, P09919

Function: Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the

production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the

monocytes-macrophages. This CSF induces granulocytes

Genatlas biochemistry entry for CSF3:

colony-stimulating factor 3,22.3kDa,(granulocyte),playing a pivotal role in growth control of granulocytic

progenitors,regulated by SPI1,MYB,others and inducing PRTN3 (see symbols),inducingJUNB and/or TOP in the proliferative

response of human myeloidleukemia,putatively involved in severe congenital neutropenia

Summary:

CSF3 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells: Granulocytes-like cells

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CSF3
		8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate CSF3 (see all 14):
		hsa-miR-30c-2* hsa-miR-577 hsa-miR-2110 hsa-miR-200a hsa-miR-548v hsa-miR-662 hsa-miR-141 hsa-miR-890

		SwitchGear 3'UTR luciferase reporter plasmid: CSF3 3' UTR sequence

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Gene Editing
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DNA2.0 Custom Protein Engineering Service for CSF3

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CSF3
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSF3

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005125	cytokine activity	NAS	15664994
GO:0005130	granulocyte colony-stimulating factor receptor binding	TAS	2420009
GO:0008083	growth factor activity	IEA	--
GO:0019899	enzyme binding	IPI	12393522

CSF3 for ontologies About GeneDecksing

Animal Models:
4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Csf3):

hematopoietic system

immune system

integument

renal/urinary system

CSF3 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

PEDF Induced Signaling

8/9 pathways (see all 9)
PEDF Induced Signaling	1.00	RAR-Gamma-RXR-Alpha Degradation	0.54
MIF Mediated Glucocorticoid Regulation	0.73	STAT3 Pathway	0.47
MIF Regulation of Innate Immune Cells	0.71	Endothelin-1 Signaling Pathway	0.44
IL-6 Pathway	0.61	Cytokine-cytokine receptor interaction	0.26

Rho Family GTPases

	Rho Family GTPases	1.00			Molecular Mechanisms of Cancer	0.51
	ERK Signaling	0.61

PAK Pathway

PAK Pathway

1.00

Antioxidant Action of Vitamin-C

0.56

Akt Signaling

Akt Signaling

1.00

p38 Signaling

0.60

Mucin expression in CF via IL-6, IL-17 signaling pathways

Cytokine production by Th17 cells in CF

0.45

Cytokine production by Th17 cells in CF (Mouse model)

0.37

Pathway sources
See GeneCards unified pathways
Show all pathways

5/15 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CSF3 (see all 15)

	MIF Regulation of Innate Immune Cells
	STAT3 Pathway
	Endothelin-1 Signaling Pathway
	Molecular Mechanisms of Cancer
	Antioxidant Action of Vitamin-C

2 GeneGo (Thomson Reuters) Pathways for CSF3

	Cytokine production by Th17 cells in CF (Mouse model)
	Cytokine production by Th17 cells in CF

1 BioSystems Pathway for CSF3

Cytokines and Inflammatory Response

4 Kegg Pathways (Kegg details for CSF3):

	Cytokine-cytokine receptor interaction
	Jak-STAT signaling pathway
	Hematopoietic cell lineage
	Malaria

CSF3 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CSF3

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

3 Interacting proteins for CSF3 (P09919³ ENSP00000225474⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ELANE	P08246³, ENSP00000263621⁴	I2D: score=1 STRING: ENSP00000263621
CSF3R	Q99062³	I2D: score=1
--	ENSP00000342623⁴	STRING: ENSP00000342623

About this table

Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006955	immune response	IEA	--
GO:0007275	multicellular organismal development	TAS	2420009
GO:0008284	positive regulation of cell proliferation	IEA	--
GO:0014068	positive regulation of phosphatidylinositol 3-kinase cascade	IDA	--
GO:0019221	cytokine-mediated signaling pathway	NAS	15664994

CSF3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CSF3 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CSF3
UniProtKB/Swiss-Prot: CSF3_HUMAN, P09919

Pharmaceutical: Available under the names Neupogen or Granulokine (Amgen/Roche) and Granocyte (Rhone-Poulenc). Used to

treat neutropenia (a disorder characterized by an extremely low number of neutrophils in blood)

10/123 Novoseek chemical compound relationships for CSF3 gene (see all 123) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
filgrastim	96	1102	11098978 (10), 19840722 (8), 10592434 (7), 9619915 (7) (see all 99)
lenograstim	90	116	9951685 (3), 7512258 (2), 12629058 (2), 12352049 (2) (see all 84)
cyclophosphamide	87.7	1090	9543059 (9), 15829405 (6), 8558227 (6), 11346706 (4) (see all 99)
pegfilgrastim	85.1	126	19076208 (7), 16982322 (5), 17064993 (4), 19308043 (4) (see all 56)
etoposide	84	450	8946866 (4), 7595759 (4), 9764585 (4), 10595815 (4) (see all 99)
cytarabine	83.6	342	7507264 (3), 8926688 (3), 9364868 (3), 8819077 (3) (see all 99)
plerixafor	82.6	185	19135941 (4), 19167685 (4), 20009003 (4), 19363221 (3) (see all 25)
ifosfamide	81.3	189	8946866 (4), 8610230 (3), 14586157 (3), 11127946 (3) (see all 99)
carboplatin	78.4	183	11127946 (4), 8826913 (3), 14632773 (3), 16781005 (3) (see all 96)
paclitaxel	78.4	532	7509652 (9), 7692001 (6), 8558227 (6), 7509380 (6) (see all 99)

Search CenterWatch for drugs/clinical trials and news about CSF3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CSF3 gene (4 alternative transcripts):

NM_000759.3 NM_001178147.1 NM_172219.2 NM_172220.2

Unigene Cluster for CSF3:

Colony stimulating factor 3 (granulocyte)

Hs.2233 [show with all ESTs]

Unigene Representative Sequence: NR_033662

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000583218 ENST00000394149(uc002htp.3 uc002hto.3 uc021tww.1 uc021twx.1)

ENST00000582798 ENST00000225474 ENST00000579852 ENST00000479880 ENST00000331769(uc002htq.3 uc010wep.2)

ENST00000394148 ENST00000577675

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CSF3
		8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate CSF3 (see all 14):
		hsa-miR-30c-2* hsa-miR-577 hsa-miR-2110 hsa-miR-200a hsa-miR-548v hsa-miR-662 hsa-miR-141 hsa-miR-890

		SwitchGear 3'UTR luciferase reporter plasmid: CSF3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector (see all 4): CSF3 (NM_000759)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSF3

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CSF3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CSF3

Additional cDNA sequence:

AB102881.1 AK290247.1 AK298116.1 AK313509.1 BC033245.1 CR541891.1 HM132049.1 M17706.1

NR_033662.1 X03438.1 X03655.1

5 DOTS entries:

DT.97840643 DT.100022617 DT.120892152 DT.91702158 DT.99933476

24/44 AceView cDNA sequences (see all 44):

CB136760 BM553432 CD013925 NM_172219 CD013924 NM_000759 BM554035 CB126975

BI822673 CD370607 X03438 BM906367 CD013926 NM_172220 CR541891 BM556479

CB127794 CD364767 X03655 BM557421 CA489884 BM923410 BF508680 CD370654

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for CSF3 (see all 9) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	·	2c	^	3a	·	3b	^	4	^	5a	·	5b	·	5c	·	5d
SP1:											-		-		-
SP2:													-		-
SP3:													-		-		-
SP4:											-		-		-
SP5:											-		-		-		-

ECgene alternative splicing isoforms for CSF3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CSF3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCAGGCCTGT

About this image

CSF3 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

See CSF3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CSF3

SOURCE GeneReport for Unigene cluster: Hs.2233

SABiosciences Expression via Pathway-Focused PCR Arrays including CSF3 (see all 19):

Lung Cancer in human mouse rat

Interferons & Receptors in human mouse rat

Wound Healing in human mouse rat

Lymphoma in human mouse rat

Th17 Response in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CSF3

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSF3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CSF3 gene from 3/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Csf3^{1 , 5}	colony stimulating factor 3 (granulocyte)^{1, 5}	78.05(n)¹ 74.26(a)¹		11 (62.45 cM)⁵ 12985¹ NM_009971.1¹ NP_034101.1¹ 98701263⁵
chicken (Gallus gallus)	Aves	CSF3¹	colony stimulating factor 3 (granulocyte)	56.84(n) 40(a)		396216 NM_205279.1 NP_990610.1
lizard (Anolis carolinensis)	Reptilia	CSF3⁶	--	27(a)	1 ↔ 1	6(68972611-68979489)

ENSEMBL Gene Tree for CSF3 (if available)
TreeFam Gene Tree for CSF3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs141355216^1,2		--	38169645(+)	`AACATA/GTTTAA`	5	--	us2k¹		0	--	--	--	--
rs11655821^1,2	C,F,H,	--	38169694(+)	`CCCACC/TCTCAA`	5	--	us2k¹		10		NS EA NA WA	1208
rs147424332^1,2		--	38169701(+)	`TCAAGA/GCCAGG`	5	--	us2k¹		0	--	--	--	--
rs12602958^1,2	C,H,	--	38169708(+)	`CAGGTG/ACAGTG`	5	--	us2k¹		2		NA EA	122
rs2227315^1,2	C,F,A,H,	--	38169714(+)	`CAGTGG/ACTCAT`	5	--	us2k¹		8		NS NA WA	100
rs186544377^1,2		--	38169800(+)	`ACCAAA/CATGGT`	5	--	us2k¹		0	--	--	--	--
rs191354512^1,2		--	38169893(+)	`GCAGGA/GAAATC`	5	--	us2k¹		0	--	--	--	--
rs2227316^1,2	C,F,A,	--	38170007(+)	`CCCACC/TCTCTA`	5	--	us2k¹		8		NS WA NA CSA	328
rs143615944^1,2		--	38170015(+)	`CTACTC/GCCAGG`	5	--	us2k¹		0	--	--	--	--
rs2227317^1,2	C,F,	--	38170065(+)	`TGAGCC/TACAGA`	5	--	us2k¹		5		NS NA WA	202

HapMap Linkage Disequilibrium report for CSF3 (38171614 - 38174066 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CSF3: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CSF3

DNA2.0 Custom Variant and Variant Library Synthesis for CSF3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CSF3 for disorders           About GeneDecksing

OMIM gene information: 138970    OMIM disorders: --

20/344 diseases for CSF3 (see all 344):    About MalaCards

graft versus host disease malignant peripheral nerve sheath tumor epithelioid malignant peripheral nerve sheath tumor acute febrile neutrophilic dermatosis

glycogen storage disease type 1b primitive neuroectodermal tumor desmoplastic small round cell tumor glycogen storage disease

leukemoid reaction b-cell non-hodgkin lymphoma supratentorial primitive neuroectodermal tumor paroxysmal nocturnal hemoglobinuria

toxic epidermal necrolysis hermansky-pudlak syndrome diffuse large b-cell lymphoma disseminated intravascular coagulation

doxorubicin induced cardiomyopathy acute graft versus host disease chronic graft versus host disease non-hodgkin lymphoma

20/22 diseases from the University of Copenhagen DISEASES database for CSF3 (see all 22):

Neutropenia Leukemia Thrombocytopenia Lymphoma

Anemia Breast cancer Multiple myeloma Lung cancer

Bone marrow disease Pneumonia Felty's syndrome Diarrhea

Stomatitis Ovarian cancer Carcinoma Myocardial infarction

Alopecia Vascular disease Peripheral neuropathy Glycogen storage disease

10/88 Novoseek disease relationships for CSF3 gene (see all 88) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
neutropenia	95	1784	17402806 (9), 12636092 (6), 1711156 (6), 10887102 (6) (see all 99)
neutropenia, severe congenital	88.5	62	7539627 (2), 11146160 (2), 17311988 (2), 16500901 (2) (see all 38)
agranulocytosis	86.2	285	15644577 (6), 9292945 (5), 18181220 (5), 7679571 (5) (see all 99)
myelodysplastic syndromes	82.7	194	19564636 (2), 9364865 (2), 7512125 (2), 7531261 (2) (see all 99)
neutropenia cyclic	81.8	70	7544058 (3), 9252852 (3), 1692489 (2), 7532983 (2) (see all 42)
leukopenia	81.7	232	9885374 (6), 9072843 (5), 17726809 (4), 19486571 (4) (see all 99)
thrombocytopenia	81.1	118	17207228 (5), 17034024 (4), 9293906 (3), 8946866 (2) (see all 91)
anemia aplastic	81	194	7540227 (4), 8587170 (3), 10629575 (3), 7504333 (3) (see all 99)
kostmanns syndrome	80.8	17	11533372 (3), 12489493 (2), 7531241 (1), 7514821 (1) (see all 11)
lymphoma non-hodgkins	78.8	342	19233728 (4), 8908287 (3), 11920216 (3), 12629058 (2) (see all 99)

Genetic Association Database (GAD): CSF3
Human Genome Epidemiology (HuGE) Navigator: CSF3 (35 documents)

Export disorders for CSF3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CSF3 gene, integrated from 9 sources (see all 4731):
(articles sorted by number of sources associating them with CSF3)

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Homodimeric cross-over structure of the human granulocyte colony- stimulating factor (GCSF) receptor signaling complex. (PubMed id 16492764)^{1, 2, 9} Tamada T....Kuroki R. (2006)
Polymorphisms in cytokine and cellular adhesion molecule genes and susceptibility to hematotoxicity among workers exposed to benzene. (PubMed id 16230423)^{1, 4} Lan Q....Rothman N. (2005)
PCR isolation and cloning of novel splice variant mRNAs from known drug target genes. (PubMed id 15028279)^{1, 2} Jin P.... Stuve L.L. (2004)
Extracellular domain of granulocyte-colony stimulating factor receptor. Interaction with its ligand and identification of a domain in close proximity of ligand-binding region. (PubMed id 8554326)^{1, 2} Haniu M.... Rohde M.F. (1995)
Structure and dynamics of the human granulocyte colony-stimulating factor determined by NMR spectroscopy. Loop mobility in a four-helix- bundle protein. (PubMed id 7518249)^{1, 2} Zink T.... Holak T.A. (1994)
The structure of granulocyte-colony-stimulating factor and its relationship to other growth factors. (PubMed id 7685117)^{1, 2} Hill C.P.... Eisenberg D. (1993)
Secondary structure of human granulocyte colony-stimulating factor derived from NMR spectroscopy. (PubMed id 1281794)^{1, 2} Zink T.... Holak T.A. (1992)
Chromosomal localization of the human G-CSF gene to 17q11 proximal to the breakpoint of the t(15;17) in acute promyelocytic leukemia. (PubMed id 3501046)^{1, 3} Le Beau M.M....Rowley J.D. (1987)
Expression of granulocyte colony-stimulating factor by human cell lines. (PubMed id 3494801)^{1, 2} Devlin J.J....Warren M.K. (1987)
Human gene coding for granulocyte-colony stimulating factor is assigned to the q21-q22 region of chromosome 17. (PubMed id 3499671)^{1, 3} Kanda N....Nagata S. (1987)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 1440	HGNC: 2438	AceView: CSF3	Ensembl:ENSG00000108342	euGenes: HUgn1440
ECgene: CSF3	Kegg: 1440	H-InvDB: CSF3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CSF3	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CSF3	Genetics and Cytogenetics in Oncology and Haematology
Neupogen/Granulokine	http://www.neupogen.com/pi.html
SeattleSNPs	http://pga.gs.washington.edu/data/csf3/

Intellectual Property for CSF3 gene
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Patent Information for CSF3 gene:
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Licensable Technologies for CSF3 gene:

Weizmann Institute:

Novel treatment for improving bone-marrow transplantation success

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CSF3 Gene

colony stimulating factor 3 (granulocyte)

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stable disease
Hematologic Effects
Leukemoid Reaction
Chronic graft-versus-host disease
sepsis
veno-occlusive disease
hematologic cancer
Leukemia Myelomonocytic Chronic
GRANULOCYTOPENIA SEVERE
Aplasia
Breast Cancer
inflammatory breast cancer
NSCLC
recurrent ovarian cancer
secondary myelodysplastic syndrome
Cancer
Glycogen Storage Disease
Thrombocytopenia
Lymphoma
Splenomegaly
Myeloproliferative Disorders
Ovarian Cancer
stage II breast cancer
NEUTROPENIA, SEVERE CONGENITAL
HEMATOLOGIC DISORDERS
Lymphoma Intermediate-Grade
evaluable disease
aggressive lymphoma
Neutropenia
Anemia
MYELOMA
Pneumonia
Tumors
DEPRESSION BONE MARROW
Sweets Syndrome
Lymphoblastic Leukemia Acute
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Anemia Refractory
breast cancer metastatic
progressive disease
Shock Septic
Paroxysmal Hemoglobinuria Nocturnal
Urogenital Cancer
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measurable disease
CML chronic phase
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TOXICITY RENAL
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Leukemia Neutrophilic Chronic
Agranulocytosis
Acute graft-versus-host disease
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Hematologic Malignancies
small cell lung cancer
NEUTROPENIA CYCLIC
INFECTION FUNGAL
cytopenia
mucositis
solid tumor
extensive stage small cell lung cancer
pediatric solid tumor
Leukemia Promyelocytic Acute
Kostmanns syndrome
primary myelofibrosis
secondary AML
Anemia Aplastic
Graft-Versus-Host Disease
residual disease
leukemogenesis
Lymphoma Non-Hodgkins
Neutropenia drug-induced
Stomatitis
Feltys Syndrome
Myelodysplastic Syndromes
recurrent breast cancer

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CSF3 Gene

colony stimulating factor 3 (granulocyte)

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