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Aliases for CSF2RB Gene

Aliases for CSF2RB Gene

  • Colony Stimulating Factor 2 Receptor Beta Common Subunit 2 3 5
  • Colony Stimulating Factor 2 Receptor, Beta, Low-Affinity (Granulocyte-Macrophage) 2 3
  • GM-CSF/IL-3/IL-5 Receptor Common Beta Subunit 3 4
  • Beta Common Cytokine Receptor 2 3
  • CDw131 3 4
  • IL3RB 3 4
  • IL5RB 3 4
  • Interleukin 3 Receptor/Granulocyte-Macrophage Colony Stimulating Factor 3 Receptor, Beta (High Affinity) 3
  • Colony-Stimulating Factor-2 Receptor, Beta, Low-Affinity 3
  • GM-CSF/IL-3/IL-5 Receptor Common Beta-Chain 3
  • Cytokine Receptor Common Subunit Beta 3
  • CD131 Antigen 4
  • CD131 3
  • SMDP5 3

External Ids for CSF2RB Gene

Previous HGNC Symbols for CSF2RB Gene

  • IL3RB

Previous GeneCards Identifiers for CSF2RB Gene

  • GC22P033932
  • GC22P035552
  • GC22P035561
  • GC22P035642
  • GC22P037309
  • GC22P020271

Summaries for CSF2RB Gene

Entrez Gene Summary for CSF2RB Gene

  • The protein encoded by this gene is the common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. Defects in this gene have been reported to be associated with protein alveolar proteinosis (PAP). [provided by RefSeq, Jul 2008]

GeneCards Summary for CSF2RB Gene

CSF2RB (Colony Stimulating Factor 2 Receptor Beta Common Subunit) is a Protein Coding gene. Diseases associated with CSF2RB include Surfactant Metabolism Dysfunction, Pulmonary, 5 and Hereditary Pulmonary Alveolar Proteinosis. Among its related pathways are PEDF Induced Signaling and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include receptor activity and interleukin-3 receptor activity.

UniProtKB/Swiss-Prot for CSF2RB Gene

  • High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSF2RB Gene

Genomics for CSF2RB Gene

Regulatory Elements for CSF2RB Gene

Enhancers for CSF2RB Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around CSF2RB on UCSC Golden Path with GeneCards custom track

Promoters for CSF2RB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for CSF2RB Gene

Chromosome:
22
Start:
36,913,575 bp from pter
End:
36,940,449 bp from pter
Size:
26,875 bases
Orientation:
Plus strand

Genomic View for CSF2RB Gene

Genes around CSF2RB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CSF2RB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CSF2RB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSF2RB Gene

Proteins for CSF2RB Gene

  • Protein details for CSF2RB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P32927-IL3RB_HUMAN
    Recommended name:
    Cytokine receptor common subunit beta
    Protein Accession:
    P32927
    Secondary Accessions:
    • Q5JZI1
    • Q6ICE0

    Protein attributes for CSF2RB Gene

    Size:
    897 amino acids
    Molecular mass:
    97336 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits. Interacts with TMEM102; this interaction occurs preferentially in the absence of CSF2. Interacts with LYN (By similarity).

    Three dimensional structures from OCA and Proteopedia for CSF2RB Gene

    Alternative splice isoforms for CSF2RB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CSF2RB Gene

Post-translational modifications for CSF2RB Gene

Other Protein References for CSF2RB Gene

No data available for DME Specific Peptides for CSF2RB Gene

Domains & Families for CSF2RB Gene

Suggested Antigen Peptide Sequences for CSF2RB Gene

Graphical View of Domain Structure for InterPro Entry

P32927

UniProtKB/Swiss-Prot:

IL3RB_HUMAN :
  • The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
  • Belongs to the type I cytokine receptor family. Type 4 subfamily.
Domain:
  • The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
  • The box 1 motif is required for JAK interaction and/or activation.
  • Contains 2 fibronectin type-III domains.
Family:
  • Belongs to the type I cytokine receptor family. Type 4 subfamily.
genes like me logo Genes that share domains with CSF2RB: view

Function for CSF2RB Gene

Molecular function for CSF2RB Gene

GENATLAS Biochemistry:
colony-stimulating factor 2 (granulocyte,macrophage), interleukin 3,interleukin 5 receptor common subunit beta (high affinity),critical for the activation of both the JAK/STAT (JAK2,STAT5) and MAP kinase pathways,involved in LYN binding
UniProtKB/Swiss-Prot Function:
High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor.

Gene Ontology (GO) - Molecular Function for CSF2RB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004713 protein tyrosine kinase activity TAS --
GO:0004872 receptor activity TAS 9410898
GO:0004912 contributes_to interleukin-3 receptor activity TAS 9410898
GO:0004914 contributes_to interleukin-5 receptor activity TAS 9410898
GO:0005088 Ras guanyl-nucleotide exchange factor activity TAS --
genes like me logo Genes that share ontologies with CSF2RB: view
genes like me logo Genes that share phenotypes with CSF2RB: view

Human Phenotype Ontology for CSF2RB Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CSF2RB Gene

MGI Knock Outs for CSF2RB:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • R&D Systems cDNA Clones for CSF2RB (Common beta Chain)

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for CSF2RB Gene

Localization for CSF2RB Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSF2RB Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CSF2RB Gene COMPARTMENTS Subcellular localization image for CSF2RB gene
Compartment Confidence
plasma membrane 5
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CSF2RB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane NAS 1702217
GO:0030526 granulocyte macrophage colony-stimulating factor receptor complex TAS 9410898
genes like me logo Genes that share ontologies with CSF2RB: view

Pathways & Interactions for CSF2RB Gene

SuperPathways for CSF2RB Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 PEDF Induced Signaling
3 TGF-Beta Pathway
4 Akt Signaling
5 G beta-gamma signalling through PI3Kgamma
genes like me logo Genes that share pathways with CSF2RB: view

Pathways by source for CSF2RB Gene

SIGNOR curated interactions for CSF2RB Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for CSF2RB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0007165 signal transduction NAS 1702217
GO:0007585 respiratory gaseous exchange TAS 9410898
GO:0018108 peptidyl-tyrosine phosphorylation IEA --
GO:0032496 response to lipopolysaccharide IEA --
genes like me logo Genes that share ontologies with CSF2RB: view

Drugs & Compounds for CSF2RB Gene

(4) Drugs for CSF2RB Gene - From: DrugBank, DGIdb, and FDA Approved Drugs

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sargramostim Approved, Investigational Pharma binder, Target, agonist 0
Leukine Approved on November 24, 1995/ Approved November 1996 Pharma 0
NPI 32101 Investigational Pharma Target 0
TPI-ASM8 Pharma 0

(1) Additional Compounds for CSF2RB Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
D-Mannose
  • (+)-mannose
  • (+-)-mannose
  • Carubinose
  • D(+)-Mannose
  • D-Mannopyranose
3458-28-4
genes like me logo Genes that share compounds with CSF2RB: view

Transcripts for CSF2RB Gene

Unigene Clusters for CSF2RB Gene

Colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • R&D Systems cDNA Clones for CSF2RB (Common beta Chain)

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CSF2RB Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: - -
SP2: -
SP3:

Relevant External Links for CSF2RB Gene

GeneLoc Exon Structure for
CSF2RB
ECgene alternative splicing isoforms for
CSF2RB

Expression for CSF2RB Gene

mRNA expression in normal human tissues for CSF2RB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CSF2RB Gene

This gene is overexpressed in Whole Blood (x28.6).

Protein differential expression in normal tissues from HIPED for CSF2RB Gene

This gene is overexpressed in Tlymphocyte (58.1) and Monocytes (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CSF2RB Gene



Protein tissue co-expression partners for CSF2RB Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CSF2RB Gene:

CSF2RB

SOURCE GeneReport for Unigene cluster for CSF2RB Gene:

Hs.592192
genes like me logo Genes that share expression patterns with CSF2RB: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for CSF2RB Gene

Orthologs for CSF2RB Gene

This gene was present in the common ancestor of chordates.

Orthologs for CSF2RB Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CSF2RB 34
  • 77.06 (n)
  • 66.78 (a)
CSF2RB 35
  • 66 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CSF2RB 34
  • 77.22 (n)
  • 65.66 (a)
CSF2RB 35
  • 65 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Csf2rb2 34
  • 69.84 (n)
  • 57.57 (a)
Csf2rb2 16
Csf2rb 35
  • 56 (a)
OneToMany
Csf2rb2 35
  • 57 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia CSF2RB 34
  • 98.72 (n)
  • 98.19 (a)
CSF2RB 35
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Csf2rb 34
  • 70.22 (n)
  • 56.34 (a)
oppossum
(Monodelphis domestica)
Mammalia CSF2RB 35
  • 39 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CSF2RB 35
  • 42 (a)
OneToOne
chicken
(Gallus gallus)
Aves CSF2RB 34
  • 49.44 (n)
  • 37.68 (a)
-- 35
  • 25 (a)
OneToMany
-- 35
  • 28 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia CSF2RB 35
  • 25 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii csf2rb 35
  • 21 (a)
OneToOne
Species where no ortholog for CSF2RB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CSF2RB Gene

ENSEMBL:
Gene Tree for CSF2RB (if available)
TreeFam:
Gene Tree for CSF2RB (if available)

Paralogs for CSF2RB Gene

Pseudogenes.org Pseudogenes for CSF2RB Gene

genes like me logo Genes that share paralogs with CSF2RB: view

No data available for Paralogs for CSF2RB Gene

Variants for CSF2RB Gene

Sequence variations from dbSNP and Humsavar for CSF2RB Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1801122 - 36,937,615(+) CCCTA(A/C)CTGAC downstream-variant-500B, reference, missense
rs1801115 - 36,937,748(+) GATGG(G/T)ACCAG downstream-variant-500B, reference, missense
rs1801114 - 36,937,762(+) AGGCC(A/G)TGGAA downstream-variant-500B, reference, missense
rs16845 - 36,930,401(+) ACCTG(C/G)AGTGC reference, missense
rs16997517 - 36,937,894(+) CTATA(C/T)CCATG downstream-variant-500B, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CSF2RB Gene

Variant ID Type Subtype PubMed ID
esv2758837 CNV gain+loss 17122850

Variation tolerance for CSF2RB Gene

Residual Variation Intolerance Score: 39.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.34; 76.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CSF2RB Gene

Human Gene Mutation Database (HGMD)
CSF2RB
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CSF2RB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSF2RB Gene

Disorders for CSF2RB Gene

MalaCards: The human disease database

(4) MalaCards diseases for CSF2RB Gene - From: OMIM, ClinVar, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
surfactant metabolism dysfunction, pulmonary, 5
  • pulmonary surfactant metabolism dysfunction 5
hereditary pulmonary alveolar proteinosis
  • congenital pap
pulmonary surfactant metabolism dysfunction
  • pulmonary alveolar proteinosis
pulmonary alveolar proteinosis
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

IL3RB_HUMAN
  • Pulmonary surfactant metabolism dysfunction 5 (SMDP5) [MIM:614370]: A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress. {ECO:0000269 PubMed:21075760}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for CSF2RB

Genetic Association Database (GAD)
CSF2RB
Human Genome Epidemiology (HuGE) Navigator
CSF2RB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CSF2RB
genes like me logo Genes that share disorders with CSF2RB: view

No data available for Genatlas for CSF2RB Gene

Publications for CSF2RB Gene

  1. Association between interleukin-3 receptor alpha polymorphism and schizophrenia in the Chinese population. (PMID: 18547720) Sun S. … Zhang X.Y. (Neurosci. Lett. 2008) 3 22 46 65
  2. An improved resolution structure of the human beta common receptor involved in IL-3, IL-5 and GM-CSF signalling which gives better definition of the high-affinity binding epitope. (PMID: 16754968) Carr P.D. … Young I.G. (Acta Crystallogr. F 2006) 3 4 22 65
  3. A genome-wide association study in Han Chinese identifies new susceptibility loci for ankylosing spondylitis. (PMID: 22138694) Lin Z. … Gu J. (Nat. Genet. 2012) 3 46 65
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 65
  5. Gene-wide analyses of genome-wide association data sets: evidence for multiple common risk alleles for schizophrenia and bipolar disorder and for overlap in genetic risk. (PMID: 19065143) Moskvina V. … O'Donovan M.C. (Mol. Psychiatry 2009) 3 46 65

Products for CSF2RB Gene

Sources for CSF2RB Gene

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