Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
- GeneCards Team
- Our Publications
- Citing GeneCards
- Licensing Agreement
- Weizmann Institute
- LifeMap Sciences Inc
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CSF2RB Gene

protein-coding GIFtS: 67
GCID: GC22P037309

Colony Stimulating Factor 2 Receptor, Beta, Low-Affinity...

(Previous symbol: IL3RB)

15 related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Colony Stimulating Factor 2 Receptor, Beta, Low-Affinity (Granulocyte-Macrophage)¹ ²		SMDP5²
IL3RB¹ ² ³		Colony-Stimulating Factor-2 Receptor, Beta, Low-Affinity²
CDw131² ³		Cytokine Receptor Common Subunit Beta²
IL5RB² ³		GM-CSF/IL-3/IL-5 Receptor Common Beta-Chain²
GM-CSF/IL-3/IL-5 Receptor Common Beta Subunit² ³		Interleukin 3 Receptor/Granulocyte-Macrophage Colony Stimulating Factor 3 Receptor, Beta (High Affinity)²
CD131²		CD131 Antigen³

External Ids:	HGNC: 2436¹	Entrez Gene: 1439²	Ensembl: ENSG00000100368⁷	OMIM: 138981⁵	UniProtKB: P32927³

Export aliases for CSF2RB gene to outside databases

Previous GC identifers: GC22P033932 GC22P035552 GC22P035561 GC22P035642 GC22P020271

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CSF2RB Gene:

The protein encoded by this gene is the common beta chain of the high affinity receptor for IL-3, IL-5 and CSF.

Defects in this gene have been reported to be associated with protein alveolar proteinosis (PAP). (provided by

RefSeq, Jul 2008)

GeneCards Summary for CSF2RB Gene:

CSF2RB (colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)) is a protein-coding gene. Diseases associated with CSF2RB include megakaryocytic leukemia, and pulmonary alveolar proteinosis, and among its related super-pathways are STAT3 Pathway and MAPK Family Pathway. GO annotations related to this gene include interleukin-5 receptor activity and receptor activity.

UniProtKB/Swiss-Prot: IL3RB_HUMAN, P32927

Function: High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating

factor

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000022.10 NT_011520.12 NC_018933.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CSF2RB gene promoter:
GR AML1a GR-beta IRF-1 RORalpha1 POU2F1 POU2F1a Chx10 ARP-1 GR-alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CSF2RB promoter sequence

Search SABiosciences Chromatin IP Primers for CSF2RB

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CSF2RB

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1 Ensembl cytogenetic band: 22q12.3 HGNC cytogenetic band: 22q12.2-q13.1

CSF2RB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CSF2RB gene location

GeneLoc information about chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22P037309: view genomic region (about GC identifiers)

Start:	37,309,670 bp from pter	End:	37,336,491 bp from pter
Size:	26,822 bases	Orientation:	plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IL3RB_HUMAN, P32927 (See protein sequence)

Recommended Name: Cytokine receptor common subunit beta precursor

Size: 897 amino acids; 97336 Da

Subunit: Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF

receptors. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two

beta, and two ligand subunits. Interacts with TMEM102; this interaction occurs preferentially in the absence of

CSF2. Interacts with LYN (By similarity)

Subcellular location: Membrane; Single-pass type I membrane protein

5 PDB 3D structures from and Proteopedia for CSF2RB:

1C8P (3D)

1EGJ (3D)

1GH7 (3D)

2GYS (3D)

3CXE (3D)

Secondary accessions: Q5JZI1 Q6ICE0

Alternative splicing: 2 isoforms: P32927-1 P32927-2

Explore the universe of human proteins at neXtProt for CSF2RB: NX_P32927

Explore proteomics data for CSF2RB at MOPED

Post-translational modifications:

UniProtKB: May be phosphorylated by LYN (By similarity)

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_P32927

CSF2RB Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_000386.1

ENSEMBL proteins:

ENSP00000384053 ENSP00000385271 ENSP00000393585 ENSP00000262825 ENSP00000440003

Reactome Protein details: P32927
Human Recombinant Protein Products for CSF2RB:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for CSF2RB (Common beta Chain)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein for CSF2RB OriGene Protein Over-expression Lysate for CSF2RB OriGene MassSpec for CSF2RB OriGene Custom Protein Services for CSF2RB
	GenScript Purified and Recombinant Proteins for CSF2RB
	Novus Biologicals CSF2RB Proteins Novus Biologicals CSF2RB Lysate
	Sino Biological Recombinant Protein for CSF2RB Sino Biological Cell Lysate for CSF2RB
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Cloud-Clone Corp.

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	NAS	1702217
GO:0016020	membrane	--	--
GO:0016021	integral to membrane	--	--
GO:0030526	granulocyte macrophage colony-stimulating factor receptor complex	TAS	9410898

CSF2RB for ontologies About GeneDecksing

CSF2RB Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for CSF2RB (Common beta Chain)
	Cell Signaling Technology (CST) Antibodies for CSF2RB
	OriGene Antibodies for CSF2RB OriGene Custom Antibody Services for CSF2RB
	GenScript Custom Superior Antibodies Services for CSF2RB
	Novus Biologicals CSF2RB Antibodies
	Abcam antibodies for CSF2RB
	Browse Antibodies at Cloud-Clone Corp.
	ThermoFisher Antibody for CSF2RB
	LSBio Antibodies in human, mouse, rat for CSF2RB

Assay Products for CSF2RB:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for CSF2RB
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CSF2RB
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

FN3: Fibronectin type III domain containing

CD: CD molecules

IUPHAR Guide to PHARMACOLOGY protein family classification: Cytokine receptor common β subunit

IL-3 receptor family

5 InterPro protein domains:

IPR015321 IL6_recept-bd

IPR003961 Fibronectin_type3

IPR013783 Ig-like_fold

IPR011365 IL3_rcpt_beta

IPR003531 Hempt_rcpt_S_F1_CS

Graphical View of Domain Structure for InterPro Entry P32927

ProtoNet protein and cluster: P32927

1 Blocks protein domain: IPB003531 Short hematopoietin receptor

UniProtKB/Swiss-Prot: IL3RB_HUMAN, P32927

Domain: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular

transport and cell-surface receptor binding

Domain: The box 1 motif is required for JAK interaction and/or activation

Similarity: Belongs to the type I cytokine receptor family. Type 4 subfamily

Similarity: Contains 2 fibronectin type-III domains

CSF2RB for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: IL3RB_HUMAN, P32927

Function: High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating

factor

Genatlas biochemistry entry for CSF2RB:

colony-stimulating factor 2 (granulocyte,macrophage), interleukin 3,interleukin 5 receptor common subunit beta

(high affinity),critical for the activation of both the JAK/STAT (JAK2,STAT5) and MAP kinase pathways,involved in

LYN binding

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	TAS	9410898
GO:0004896	cytokine receptor activity	--	--
GO:0004912	contributes to interleukin-3 receptor activity	TAS	9410898
GO:0004914	contributes to interleukin-5 receptor activity	TAS	9410898
GO:0005515	protein binding	IPI	1495999

CSF2RB for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for CSF2RB:

Increased 8N DNA content

5 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Csf2rb):

cellular

hematopoietic system

homeostasis/metabolism

immune system

respiratory system

CSF2RB for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-outs for CSF2RB: Csf2rb^tm1Clsc Csf2rb^tm1Mur Csf2rb^tm1Cgb

inGenious Targeting Laboratory - Custom generated mouse model solutions for CSF2RB

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CSF2RB

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CSF2RB

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CSF2RB

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CSF2RB
		7 QIAGEN miScript miRNA Assays for microRNAs that regulate CSF2RB:
		hsa-miR-365 hsa-miR-576-5p hsa-miR-19b hsa-miR-889 hsa-miR-155 hsa-miR-4282 hsa-miR-19a
		SwitchGear 3'UTR luciferase reporter plasmid: CSF2RB 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for CSF2RB
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CSF2RB

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for CSF2RB
			Sirion Biotech Customized adenovirus for overexpression of CSF2RB

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene clones in human, mouse for CSF2RB (see all 7) OriGene ORF clones in mouse, rat for CSF2RB OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CSF2RB (NM_000395)
		Sino Biological Human cDNA Clone for CSF2RB
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CSF2RB
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSF2RB
		Sirion Biotech Customized lentivirus for stable overexpression of CSF2RB Customized lentivirus expression plasmids for stable overexpression of CSF2RB

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CSF2RB
		Search LifeMap BioReagents cell lines for CSF2RB

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSF2RB

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for CSF2RB About (see all 18)

See pathways by source

SuperPath

Contained pathways About

PEDF Induced Signaling

	PGC1Alpha Pathway	0.51			Glucocorticoid Receptor Signaling	0.43
	STAT3 Pathway	0.47			Cytokine-cytokine receptor interaction	0.43

TGF-Beta Pathway

	TGF-Beta Pathway	0.60			JAK-STAT Pathway	0.57
	MAPK Family Pathway	0.60			JNK Pathway	0.51

Interleukin-3, 5 and GM-CSF signaling

	Interleukin receptor SHC signaling	0.67			Interleukin-3, 5 and GM-CSF signaling	0.57
	Interleukin-2 signaling	0.67			Signaling by Interleukins	0.45

Akt Signaling

	Akt Signaling	0.60			Tec Kinases Signaling	0.55
	p38 Signaling	0.60

Interferon Signaling

Cytokine Signaling in Immune system

0.61

Pathways by source See SuperPaths
Show all pathways

1 EMD Millipore Pathway for CSF2RB

Immune response IL-3 activation and signaling pathway

5/15 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CSF2RB (see all 15)

	MSP-RON Signaling
	STAT3 Pathway
	Molecular Mechanisms of Cancer
	Antioxidant Action of Vitamin-C
	Glucocorticoid Receptor Signaling

1 Cell Signaling Technology (CST) Pathway for CSF2RB

Jak/Stat Pathway

1 GeneGo (Thomson Reuters) Pathway for CSF2RB

Immune response IL-3 activation and signaling pathway

3 BioSystems Pathways for CSF2RB

	IL-5 Signaling Pathway
	Kit Receptor Signaling Pathway
	IL-3 Signaling Pathway

5/6 Reactome Pathways for CSF2RB (see all 6)

	Interleukin receptor SHC signaling
	Interleukin-2 signaling
	Cytokine Signaling in Immune system
	Interleukin-3, 5 and GM-CSF signaling
	Signaling by Interleukins

3 Kegg Pathways (Kegg details for CSF2RB):

	Cytokine-cytokine receptor interaction
	Apoptosis
	Jak-STAT signaling pathway

CSF2RB for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CSF2RB

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/67 Interacting proteins for CSF2RB (P32927^{1, 2, 3} ENSP00000384053⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 67)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SHC1	P29353²^,³, ENSP00000401303⁴	MINT-8286845 MINT-8286769 MINT-8286829 MINT-8035467 I2D: score=6 STRING: ENSP00000401303
PTPN11	Q06124²^,³, ENSP00000340944⁴	MINT-8035452 MINT-8035437 I2D: score=5 STRING: ENSP00000340944
IL5	P05113¹^,³, ENSP00000231454⁴	EBI-1809771,EBI-2435811 I2D: score=1 STRING: ENSP00000231454
PIK3R1	P27986², ENSP00000274335⁴	MINT-8286845 MINT-8286707 MINT-8286769 MINT-8286829 STRING: ENSP00000274335
JAK2	O60674¹^,²^,³, ENSP00000371067⁴	EBI-1809771,EBI-518647 MINT-8286707 I2D: score=5 STRING: ENSP00000371067

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	NAS	1702217
GO:0007585	respiratory gaseous exchange	TAS	9410898
GO:0019221	cytokine-mediated signaling pathway	--	--
GO:0036016	cellular response to interleukin-3	TAS	9410898
GO:0038043	interleukin-5-mediated signaling pathway	TAS	9410898

CSF2RB for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CSF2RB (IL3RB)

2 DrugBank Compounds for CSF2RB About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Sargramostim	Colony-stimulating factor (see all 5)	83869-56-1	target	agonist	17139284 1424804 17016423
Alpha-D-Mannose	--	3458-28-4	target	--	--

Search CenterWatch for drugs/clinical trials and news about CSF2RB / IL3RB

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CSF2RB gene:

NM_000395.2

Unigene Cluster for CSF2RB:

Colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)

Hs.592192 [show with all ESTs]

Unigene Representative Sequence: NM_000395

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000403662(uc003aqa.4) ENST00000406230 ENST00000421539 ENST00000262825(uc003aqc.4)

ENST00000536485

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CSF2RB
		7 QIAGEN miScript miRNA Assays for microRNAs that regulate CSF2RB:
		hsa-miR-365 hsa-miR-576-5p hsa-miR-19b hsa-miR-889 hsa-miR-155 hsa-miR-4282 hsa-miR-19a
		SwitchGear 3'UTR luciferase reporter plasmid: CSF2RB 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for CSF2RB
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CSF2RB

Clone Products:		OriGene clones in human, mouse for CSF2RB (see all 7) OriGene ORF clones in mouse, rat for CSF2RB OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CSF2RB (NM_000395)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CSF2RB
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSF2RB
		Sirion Biotech Customized lentivirus for stable overexpression of CSF2RB Customized lentivirus expression plasmids for stable overexpression of CSF2RB

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for CSF2RB
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CSF2RB
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CSF2RB
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CSF2RB

Additional mRNA sequence:

AK302993.1 BC070085.1 CR456428.1 M59941.1

5 DOTS entries:

DT.99935002 DT.100744002 DT.101956029 DT.100687954 DT.453853

24/112 AceView cDNA sequences (see all 112):

BU617730 CR604461 BC070085 CA306570 CA448651 AA279147 CR456428 AU185738

AI718599 AI523112 BF002507 NM_000395 BX450991 M59941 AA847136 AA960845

H55302 AI379138 C01377 CA428322 AA768316 AA761543 BG571722 AV712344

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for CSF2RB About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8a	·	8b	^	9	^	10	^	11	^	12	^	13	^	14
SP1:					-														-
SP2:					-
SP3:

ECgene alternative splicing isoforms for CSF2RB

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CSF2RB expression in normal human tissues (normalized intensities) CSF2RB embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TACCTGAAGT

About this image

CSF2RB expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/7 selected tissues (see all 7) fully expand


Blood (Hematopoietic System) fully expand to see all 3 entries
Plasmacytoid Dendritic cells Peripheral Blood
Umbilical cord blood-derived hematopoietic stem cells

Thymus (Hematopoietic System)
T Helper Cells Thymus

Ovary (Reproductive System)
Cumulus Cells Antral Follicle

Umbilical Cord (Extraembryonic Tissues)
Umbilical cord blood-derived hematopoietic stem cells

Lymph (Hematopoietic System)
Lymphnode

See CSF2RB Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CSF2RB

SOURCE GeneReport for Unigene cluster: Hs.592192

SABiosciences Expression via Pathway-Focused PCR Arrays including CSF2RB:

NFKB Signaling Targets in human mouse rat

Interferons & Receptors in human mouse rat

Inflammatory Response & Autoimmunity 384HT in human mouse rat

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for CSF2RB
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CSF2RB
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CSF2RB
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CSF2RB

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSF2RB

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CSF2RB gene from 4/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Csf2rb⁵ Csf2rb2¹	colony stimulating factor 2 receptor, beta, low-affinity more⁵ colony stimulating factor 2 receptor, beta 2, low-affinity more¹	69.84(n)¹ 57.57(a)¹		15 (37.36 cM)⁵ 12984¹ NM_007781.2¹ NP_031807.1¹ 78325990⁵
chicken (Gallus gallus)	Aves	CSF2RB¹	colony stimulating factor 2 receptor, beta, low-affinity more	48.8(n) 36.7(a)		771315 XM_001234608.2 XP_001234609.2
lizard (Anolis carolinensis)	Reptilia	CSF2RB⁶	colony stimulating factor 2 receptor, beta, low-af...	25(a)	1 ↔ 1	5(22624398-22652867)
zebrafish (Danio rerio)	Actinopterygii	csf2rb⁶	colony stimulating factor 2 receptor, beta, low-af...	18(a)	1 ↔ 1	3(24609384-24623449)

ENSEMBL Gene Tree for CSF2RB (if available)
TreeFam Gene Tree for CSF2RB (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CSF2RB gene

CSF2RB for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for CSF2RB
PGOHUM00000259706

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 22 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs12628495^1,2	C,H	--	21224716(+)	`ATATAC/TGAGTT`	1	--	us2k¹		5		NA CSA WA EA	362
rs143498372^1,2		--	21224771(+)	`CATCTA/GTAAGG`	1	--	us2k¹		0	--	--	--	--
rs188716198^1,2		--	21224834(+)	`CAGCCA/GAAGGT`	1	--	us2k¹		0	--	--	--	--
rs73883973^1,2	C	--	21224845(+)	`CTGCTC/TACAGC`	1	--	us2k¹		3		WA NA	240
rs16997492^1,2	C,F	--	21224870(+)	`CCTGGT/CCATTA`	1	--	us2k¹		6		NA WA	380
rs191539811^1,2		--	21224930(+)	`AGATCA/GTCAAT`	1	--	us2k¹		0	--	--	--	--
rs182165558^1,2		--	21224959(+)	`ACATAA/CCACTG`	1	--	us2k¹		0	--	--	--	--
rs187204280^1,2		--	21224966(+)	`ACTGAA/CGGAAA`	1	--	us2k¹		0	--	--	--	--
rs114536776^1,2	C,F	--	21225104(+)	`CTCTAT/CGATGA`	1	--	us2k¹		1		WA	118
rs115153794^1,2	C,F	--	21225212(+)	`GTCTCG/TGGTTC`	1	--	us2k¹		1		WA	118

HapMap Linkage Disequilibrium report for CSF2RB (37309670 - 37336491 bp)

Structural Variations
Database of Genomic Variants (DGV) 2 variations for CSF2RB: About this table

Variant ID	Type	Subtype	PubMed ID
nsv915010	CNV	Loss	21882294
dgv1405e1	CNV	Complex	17122850

Human Gene Mutation Database (HGMD): CSF2RB

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CSF2RB

DNA2.0 Custom Variant and Variant Library Synthesis for CSF2RB

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OMIM gene information: 138981 OMIM disorders: --

UniProtKB/Swiss-Prot: IL3RB_HUMAN, P32927

Pulmonary surfactant metabolism dysfunction 5 (SMDP5) [MIM:614370]: A rare lung disorder due to impaired

surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive

using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components.

Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress. Note=The disease is

caused by mutations affecting the gene represented in this entry

15 diseases for CSF2RB: About MalaCards

megakaryocytic leukemia pulmonary alveolar proteinosis rubella cblc

atopy ankylosing spondylitis spondylitis herpes simplex

influenza schizophrenia cervical cancer bipolar disorder

asthma cervicitis leukemia

1 disease from the University of Copenhagen DISEASES database for CSF2RB:

Pulmonary alveolar proteinosis

CSF2RB for disorders About GeneDecksing

Genetic Association Database (GAD): CSF2RB
Human Genome Epidemiology (HuGE) Navigator: CSF2RB (14 documents)

Export disorders for CSF2RB gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CSF2RB gene, integrated from 9 sources (see all 101):
(articles sorted by number of sources associating them with CSF2RB)

Utopia: connect your pdf to the dynamic
world of online information

Association between interleukin-3 receptor alpha polymorphism and schizophrenia in the Chinese population. (PubMed id 18547720)^{1, 4, 9} Sun S....Zhang X.Y. (2008)
An improved resolution structure of the human beta common receptor involved in IL-3, IL-5 and GM-CSF signalling which gives better definition of the high-affinity binding epitope. (PubMed id 16754968)^{1, 2, 9} Carr P.D.... Young I.G. (2006)
A genome-wide association study in Han Chinese identif ies new susceptibility loci for ankylosing spondylitis. (PubMed id 22138694)^{1, 4} Lin Z....Gu J. (2012)
Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)^{1, 4} Bailey S.D....Anand S. (2010)
Gene-wide analyses of genome-wide association data sets: evidence for multiple common risk alleles for schizophrenia and bipolar disorder and for overlap in genetic risk. (PubMed id 19065143)^{1, 4} Moskvina V....O'Donovan M.C. (2009)
High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)^{1, 4} Yerges L.M....Zmuda J.M. (2009)
Interaction between interleukin 3 and dystrobrevin-binding protein 1 in schizophrenia. (PubMed id 18804346)^{1, 4} Edwards T.L....Chen X. (2008)
CBAP interacts with the un-liganded common beta-subunit of the GM-CSF/IL-3/IL-5 receptor and induces apoptosis via mitochondrial dysfunction. (PubMed id 17828305)^{1, 2} Kao C.J....Yen J.J. (2008)
The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation. (PubMed id 18692472)^{1, 2} Hansen G....Parker M.W. (2008)
Polymorphisms in eosinophil pathway genes, asthma and atopy. (PubMed id 17362254)^{1, 4} Kabesch M....Nickel R. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 1439	HGNC: 2436	AceView: CSF2RB	Ensembl:ENSG00000100368	euGenes: HUgn1439
ECgene: CSF2RB	Kegg: 1439	H-InvDB: CSF2RB

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CSF2RB	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CSF2RB	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for CSF2RB gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CSF2RB gene:
Search GeneIP for patents involving CSF2RB

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for CSF2RB (Common beta Chain)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Protease Activity Assays and Reagents		Recombinant/Natural Proteins for CSF2RB (Common beta Chain)
	Browse Stem Cell Products		Browse Tocris Biochemicals & Compounds
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	OriGene Antibodies for CSF2RB		OriGene RNAi products in human, mouse, rat for CSF2RB
	Browse OriGene qPCR primer pairs and template standards		OriGene Protein Over-expression Lysate for CSF2RB
	OriGene MassSpec something-or-other for CSF2RB		OriGene clones in human, mouse for CSF2RB
	OriGene qSTAR qPCR primer pairs in human, mouse for CSF2RB		OriGene Purified Protein for CSF2RB
	OriGene ORF clones in mouse, rat for CSF2RB		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for CSF2RB		OriGene Custom Protein Services for CSF2RB

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CSF2RB
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CSF2RB
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CSF2RB
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CSF2RB
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CSF2RB
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CSF2RB

	GenScript Purified and Recombinant Proteins for CSF2RB		GenScript cDNA clones with any tag delivered in your preferred vector for CSF2RB
	GenScript Custom Assay Services for CSF2RB		GenScript Custom Superior Antibodies Services for CSF2RB
	GenScript Custom overexpressing Cell Line Services for CSF2RB		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Antibodies & Assays for CSF2RB

	Regulatory tfbs in CSF2RB promoter
	Search Chromatin IP Primers for CSF2RB
	RT² qPCR Primer Assay in human, mouse, rat CSF2RB
	Search GNC Networks for CSF2RB
	SABiosciences PCR Arrays including human, mouse, rat CSF2RB

Search Tocris compounds for CSF2RB (IL3RB)

	Proteins and Antibodies for CSF2RB
	Cell Lysates for CSF2RB
	cDNA Clones for CSF2RB
	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
	Transfection Reagents
	Protein A/G/L resins
	Isotyping reagents

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	CSF2RB antibodies
	CSF2RB proteins
	CSF2RB lysates

	Antibodies for CSF2RB
	See all of Abcam's Antibodies, Kits and Proteins for CSF2RB
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

	Browse Proteins at Cloud-Clone Corp.
	Browse Antibodies at Cloud-Clone Corp.
	Browse ELISAs at Cloud-Clone Corp.
	Browse CLIAs at Cloud-Clone Corp.

Search LifeMap BioReagents cell lines for CSF2RB

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSF2RB

	SwitchGear 3'UTR luciferase reporter plasmids for CSF2RB
	SwitchGear Promoter luciferase reporter plasmids for CSF2RB

ThermoFisher Antibody for CSF2RB

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSF2RB

	inGenious Targeting Laboratory - Custom generated mouse model solutions for CSF2RB
	inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CSF2RB

Customized:

	lentivirus for stable overexpression of CSF2RB
	lentivirus expression plasmids for stable overexpression of CSF2RB
	adenovirus for overexpression of CSF2RB

LSBio Antibodies in human, mouse, rat for CSF2RB

Customized transgenic rodents for:

	Humanization
	Biomarker expression
	Off-target effect monitoring
	Translational medicine
	Tissue-specific gene expresssion
	Time-controlled gene expresssion

GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

View Random Gene

Category			TGFB1 (GIFtS: 73) transforming growth factor, beta 1
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes CSF2RB gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

CSF2RB Gene

Colony Stimulating Factor 2 Receptor, Beta, Low-Affinity...

Aliases
for CSF2RB gene

Summaries
for CSF2RB gene

Genomic Views
for CSF2RB gene

Proteins
for CSF2RB gene

Protein Domains /
Families
for CSF2RB gene

Function
for CSF2RB gene

Pathways & Interactions
for CSF2RB gene

Drugs & Compounds
for CSF2RB gene

Transcripts
for CSF2RB gene

Expression
for CSF2RB gene

Orthologs
for CSF2RB gene

Paralogs
for CSF2RB gene

Genomic Variants
for CSF2RB gene

Disorders / Diseases
for CSF2RB gene

Publications
for CSF2RB gene

External Searches for CSF2RB gene

Genome Databases showing CSF2RB gene

Other Databases showing CSF2RB gene

Specialized Databases showing CSF2RB gene

Intellectual Property
for CSF2RB gene

Products
for CSF2RB gene

View Random Gene

Advanced Search

Export list of displayed genes

CSF2RB Gene

Colony Stimulating Factor 2 Receptor, Beta, Low-Affinity...

Aliasesfor CSF2RB gene

Summariesfor CSF2RB gene

Genomic Viewsfor CSF2RB gene

Proteinsfor CSF2RB gene

Protein Domains /Familiesfor CSF2RB gene

Functionfor CSF2RB gene

Pathways & Interactionsfor CSF2RB gene

Drugs & Compoundsfor CSF2RB gene

Transcriptsfor CSF2RB gene

Expression for CSF2RB gene

Orthologsfor CSF2RB gene

Paralogsfor CSF2RB gene

Genomic Variantsfor CSF2RB gene

Disorders / Diseasesfor CSF2RB gene

Publicationsfor CSF2RB gene

External Searches for CSF2RB gene

Genome Databases showing CSF2RB gene

Other Databases showing CSF2RB gene

Specialized Databases showing CSF2RB gene

Intellectual Propertyfor CSF2RB gene

Productsfor CSF2RB gene

View Random Gene

Aliases
for CSF2RB gene

Summaries
for CSF2RB gene

Genomic Views
for CSF2RB gene

Proteins
for CSF2RB gene

Protein Domains /
Families
for CSF2RB gene

Function
for CSF2RB gene

Pathways & Interactions
for CSF2RB gene

Drugs & Compounds
for CSF2RB gene

Transcripts
for CSF2RB gene

Expression
for CSF2RB gene

Orthologs
for CSF2RB gene

Paralogs
for CSF2RB gene

Genomic Variants
for CSF2RB gene

Disorders / Diseases
for CSF2RB gene

Publications
for CSF2RB gene

Intellectual Property
for CSF2RB gene

Products
for CSF2RB gene