CSF2RB Gene

Aliases
for CSF2RB gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC22P033932 GC22P035552 GC22P035561 GC22P035642 GC22P020271

Summaries
for CSF2RB gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for CSF2RB gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000022.10  NT_011520.13  NC_018933.2  

SwitchGear Promoter luciferase reporter plasmid: CSF2RB promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CSF2RB

CSF2RB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P037309:  view genomic region     (about GC identifiers)

Proteins
for CSF2RB gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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5 PDB 3D structures from and Proteopedia for CSF2RB:

1C8P (3D)        1EGJ (3D)        1GH7 (3D)        2GYS (3D)        3CXE (3D)    

Explore the universe of human proteins at neXtProt for CSF2RB: NX_P32927

Explore proteomics data for CSF2RB at MOPED

Post-translational modifications: 

CSF2RB Human Recombinant Protein Products:

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	Browse Proteins at Cloud-Clone Corp.
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	antibodies-online proteins for CSF2RB (4 products)
	antibodies-online peptides for CSF2RB

CSF2RB Antibody Products:

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	ThermoFisher Antibody for CSF2RB
	antibodies-online antibodies for CSF2RB (71 products)

CSF2RB Assay Products:

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	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.
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	antibodies-online kits for CSF2RB (11 products)

Domains /
Families
for CSF2RB gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: P32927

Find genes that share domains with CSF2RB           About GenesLikeMe

Function
for CSF2RB gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 5 molecular function terms:    About this table

(inferred from 3 alleles) (MGI details for Csf2rb)

genOway: Develop your customized and physiologically relevant rodent model for CSF2RB

miRNA Products:		Block miRNA regulation of human, mouse, rat CSF2RB using miScript Target Protectors
		7 qRT-PCR Assays for microRNAs that regulate CSF2RB:
		hsa-miR-365 hsa-miR-576-5p hsa-miR-19b hsa-miR-889 hsa-miR-155 hsa-miR-4282 hsa-miR-19a
		SwitchGear 3'UTR luciferase reporter plasmid: CSF2RB 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for CSF2RB
		Predesigned siRNA for gene silencing in human, mouse, rat CSF2RB

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for CSF2RB

Clone Products:		OriGene clones in human, mouse for CSF2RB (see all 7) OriGene ORF clones in mouse, rat for CSF2RB OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CSF2RB (NM_000395)
		Sino Biological Human cDNA Clone for CSF2RB
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CSF2RB
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSF2RB

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		Browse ESI BIO Cell Lines and PureStem Progenitors for CSF2RB

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSF2RB

Localization
for CSF2RB gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
plasma membrane	5
cytosol	1
extracellular	1
nucleus	1
peroxisome	1

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Gene Ontology (GO): 5 cellular component terms:    About this table

Pathways & Interactions
for CSF2RB gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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SuperPaths for CSF2RB About   (see all 17)   See pathways by source

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	SuperPath	Contained pathways About
1	PEDF Induced Signaling	PGC1Alpha Pathway 0.51 Glucocorticoid Receptor Signaling 0.43 STAT3 Pathway 0.47 Cytokine-cytokine receptor interaction 0.43
2	TGF-Beta Pathway	TGF-Beta Pathway 0.60 JAK-STAT Pathway 0.57 MAPK Family Pathway 0.60 JNK Pathway 0.51
3	Signaling by Interleukins	Interleukin receptor SHC signaling 0.67 Interleukin-3, 5 and GM-CSF signaling 0.59 Interleukin-2 signaling 0.67 Signaling by Interleukins 0.42
4	Akt Signaling	Akt Signaling 0.60 Tec Kinases Signaling 0.55 p38 Signaling 0.60
5	p70S6K Signaling	p70S6K Signaling 0.60

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CSF2RB

	MSP-RON Signaling
	STAT3 Pathway
	Molecular Mechanisms of Cancer
	Antioxidant Action of Vitamin-C
	Glucocorticoid Receptor Signaling

1 Cell Signaling Technology (CST) Pathway for CSF2RB

Jak/Stat Pathway

1 GeneGo (Thomson Reuters) Pathway for CSF2RB

Immune response IL-3 activation and signaling pathway

3 BioSystems Pathways for CSF2RB

	IL-5 Signaling Pathway
	Kit Receptor Signaling Pathway
	IL-3 Signaling Pathway

2 Reactome Pathways for CSF2RB

	Interleukin receptor SHC signaling
	Interleukin-3, 5 and GM-CSF signaling

3 Kegg Pathways  (Kegg details for CSF2RB)

	Cytokine-cytokine receptor interaction
	Apoptosis
	Jak-STAT signaling pathway

Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

Drugs & Compounds
for CSF2RB gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for CSF2RB gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for CSF2RB gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CSF2RB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TACCTGAAGT

About this image

Blood (Hematopoietic System)    fully expand to see all 4 entries
Granulocytes Peripheral Blood
Thymus (Hematopoietic System)
T Helper Cells Thymus
Ovary (Reproductive System)
Cumulus Cells Antral Follicle
Yolk Sac (Extraembryonic Tissues)
Definitive Hematopoietic Stem Cells Definitive Yolk Sac
Tonsil (Hematopoietic System)

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		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CSF2RB
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		QuantiFast Probe-based Assays in human, mouse, rat CSF2RB

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSF2RB

Orthologs
for CSF2RB gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for CSF2RB gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for CSF2RB gene

Find genes that share paralogs with CSF2RB           About GenesLikeMe


1 Pseudogenes.org Pseudogene for CSF2RB
PGOHUM00000259706

Genomic Variants
for CSF2RB gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for CSF2RB (see all 873)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 22 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs126284951,2	C,H	--	21224716(+)	ATATAC/TGAGTT	1	--	us2k1		5		NA CSA WA EA	362
rs1434983721,2		--	21224771(+)	CATCTA/GTAAGG	1	--	us2k1		0	--	--	--	--
rs1887161981,2		--	21224834(+)	CAGCCA/GAAGGT	1	--	us2k1		0	--	--	--	--
rs738839731,2	C	--	21224845(+)	CTGCTC/TACAGC	1	--	us2k1		3		WA NA	240
rs169974921,2	C,F	--	21224870(+)	CCTGGT/CCATTA	1	--	us2k1		6		NA WA	380
rs1915398111,2		--	21224930(+)	AGATCA/GTCAAT	1	--	us2k1		0	--	--	--	--
rs1821655581,2		--	21224959(+)	ACATAA/CCACTG	1	--	us2k1		0	--	--	--	--
rs1872042801,2		--	21224966(+)	ACTGAA/CGGAAA	1	--	us2k1		0	--	--	--	--
rs1145367761,2	C,F	--	21225104(+)	CTCTAT/CGATGA	1	--	us2k1		1		WA	118
rs1151537941,2	C,F	--	21225212(+)	GTCTCG/TGGTTC	1	--	us2k1		1		WA	118

HapMap Linkage Disequilibrium report for CSF2RB (37309670 - 37336491 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for CSF2RB:    About this table    

Variant ID	Type	Subtype	PubMed ID
nsv915010	CNV	Loss	21882294
dgv1405e1	CNV	Complex	17122850

Human Gene Mutation Database (HGMD): CSF2RB

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing CSF2RB

DNA2.0 Custom Variant and Variant Library Synthesis for CSF2RB

Disorders / Diseases
for CSF2RB gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for CSF2RB gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. Association between interleukin-3 receptor alpha polymorphism and schizophrenia in the Chinese population. (PubMed id 18547720)^{1, 4, 9} Sun S....Zhang X.Y. (Neurosci. Lett. 2008)
2. An improved resolution structure of the human beta common receptor involved in IL-3, IL-5 and GM-CSF signalling which gives better definition of the high-affinity binding epitope. (PubMed id 16754968)^{1, 2, 9} Carr P.D.... Young I.G. (Acta Crystallogr. F 2006)
3. A genome-wide association study in Han Chinese identifies new susceptibility loci for ankylosing spondylitis. (PubMed id 22138694)^{1, 4} Lin Z....Gu J. (Nat. Genet. 2012)
4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)^{1, 4} Bailey S.D....Anand S. (Diabetes Care 2010)
5. Gene-wide analyses of genome-wide association data sets: evidence for multiple common risk alleles for schizophrenia and bipolar disorder and for overlap in genetic risk. (PubMed id 19065143)^{1, 4} Moskvina V....O'Donovan M.C. (Mol. Psychiatry 2009)
6. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)^{1, 4} Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
7. Interaction between interleukin 3 and dystrobrevin-binding protein 1 in schizophrenia. (PubMed id 18804346)^{1, 4} Edwards T.L....Chen X. (Schizophr. Res. 2008)
8. CBAP interacts with the un-liganded common beta-subunit of the GM- CSF/IL-3/IL-5 receptor and induces apoptosis via mitochondrial dysfunction. (PubMed id 17828305)^{1, 2} Kao C.J....Yen J.J. (Oncogene 2008)
9. The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation. (PubMed id 18692472)^{1, 2} Hansen G.... Parker M.W. (Cell 2008)
10. Polymorphisms in eosinophil pathway genes, asthma and atopy. (PubMed id 17362254)^{1, 4} Kabesch M....Nickel R. (Allergy 2007)

External Searches for CSF2RB gene

Genome Databases showing CSF2RB gene

Other Databases showing CSF2RB gene

Specialized Databases showing CSF2RB gene

Products
for CSF2RB gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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