Aliases for CSF2RA Gene
Aliases for CSF2RA Gene
- Colony Stimulating Factor 2 Receptor Alpha Subunit 2 3
- Colony Stimulating Factor 2 Receptor, Alpha, Low-Affinity (Granulocyte-Macrophage) 2 3 5
- GM-CSF-R-Alpha 3 4
- CD116 Antigen 3 4
- GMCSFR-Alpha 3 4
- GMR-Alpha 3 4
- CDw116 3 4
- CSF2RY 3 4
- CSF2R 3 4
- Granulocyte-Macrophage Colony-Stimulating Factor Receptor Alpha Chain 3
External Ids for CSF2RA Gene
Previous HGNC Symbols for CSF2RA Gene
- CSF2R
Previous GeneCards Identifiers for CSF2RA Gene
- GC00U990072
- GC0YU900008
- GC0YM001355
- GC0XM001355
- GC0XP001347
Summaries for CSF2RA Gene
-
The protein encoded by this gene is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. This gene is found in the pseudoautosomal region (PAR) of the X and Y chromosomes. Multiple transcript variants encoding different isoforms have been found for this gene, with some of the isoforms being membrane-bound and others being soluble. [provided by RefSeq, Jul 2008]
GeneCards Summary for CSF2RA Gene
CSF2RA (Colony Stimulating Factor 2 Receptor Alpha Subunit) is a Protein Coding gene. Diseases associated with CSF2RA include Surfactant Metabolism Dysfunction, Pulmonary, 4 and Hereditary Pulmonary Alveolar Proteinosis. Among its related pathways are Interleukin-3, 5 and GM-CSF signaling and G beta-gamma signalling through PI3Kgamma. GO annotations related to this gene include receptor activity and cytokine receptor activity. An important paralog of this gene is IL3RA.
UniProtKB/Swiss-Prot for CSF2RA Gene
-
Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells.
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSF2RA Gene
Genomics for CSF2RA Gene
Regulatory Elements for CSF2RA Gene
Enhancers for CSF2RA Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around CSF2RA on UCSC Golden Path with GeneCards custom track
Promoters for CSF2RA Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around CSF2RA on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the CSF2RA gene promoter:
Regulatory Element Products
Genomic Location for CSF2RA Gene
- Chromosome:
- X
- Start:
- 1,268,800 bp from pter
- End:
- 1,325,078 bp from pter
- Size:
- 56,279 bases
- Orientation:
- Plus strand
Genomic View for CSF2RA Gene
Genes around CSF2RA on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- Xp22.33 by Ensembl
- Xp22.32 and Yp11.3 by Entrez Gene
- Xp22.32 and Yp11.3 by HGNC
CSF2RA Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CSF2RA Gene
Proteins for CSF2RA Gene
-
Protein details for CSF2RA Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P15509-CSF2R_HUMAN
- Recommended name:
- Granulocyte-macrophage colony-stimulating factor receptor subunit alpha
- Protein Accession:
- P15509
- A7J003
- A8KAM1
- B4DW68
- J3JS76
- J3JS77
- O00207
- Q14429
- Q14430
- Q14431
- Q16564
Protein attributes for CSF2RA Gene
- Size:
- 400 amino acids
- Molecular mass:
- 46207 Da
- Quaternary structure:
-
- Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits.
- Miscellaneous:
-
- The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.
- SequenceCaution:
-
- Sequence=AAA60962.1; Type=Miscellaneous discrepancy; Evidence={ECO:0000305};
Protein Expression for CSF2RA Gene
Post-translational modifications for CSF2RA Gene
Other Protein References for CSF2RA Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for CSF2RA
- R&D Systems Antibodies for CSF2RA (GM-CSF R alpha)
- Novus Biologicals Antibodies for CSF2RA
- Abcam antibodies for GM-CSF Receptor alpha
-
Cloud-Clone Corp. Antibodies for CSF2RA
- Invitrogen Antibodies for CSF2RA
- antibodies-online Antibodies for CSF2RA: See all 117
- GeneTex CSF2RA antibody for CSF2RA
-
Santa Cruz Biotechnology (SCBT) Antibodies for CSF2RA
Protein Products
- R&D Systems Proteins and Enzymes for CSF2RA (GM-CSF R alpha)
- Search Origene for MassSpec and Protein Over-expression Lysates for CSF2RA
- Origene Custom Protein Services for CSF2RA
- Sino Biological Recombinant Proteins for CSF2RA
- Sino Biological Cell Lysates for CSF2RA
-
Cloud-Clone Corp. Proteins for CSF2RA
- antibodies-online Proteins for CSF2RA: See all 23
- Search antibodies-online for peptides
- Search GeneTex for Proteins for CSF2RA
- Abcam proteins for GM-CSF Receptor alpha
Assay Products
- antibodies-online Kits for CSF2RA: See all 28
No data available for DME Specific Peptides for CSF2RA Gene
Domains & Families for CSF2RA Gene
Gene Families for CSF2RA Gene
Protein Domains for CSF2RA Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for CSF2RA Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P15509UniProtKB/Swiss-Prot:
CSF2R_HUMAN :- The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
- Belongs to the type I cytokine receptor family. Type 5 subfamily.
- Domain:
-
- The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
- The box 1 motif is required for JAK interaction and/or activation.
- Contains 1 fibronectin type-III domain.
- Family:
-
- Belongs to the type I cytokine receptor family. Type 5 subfamily.
Function for CSF2RA Gene
Molecular function for CSF2RA Gene
- GENATLAS Biochemistry:
- colony-stimulating factor (CSF2) receptor,X-linked (granulocyte macrophage) directly intervening in the activation of JAK2 and STAT5 (JAK/STAT pathway)
- UniProtKB/Swiss-Prot Function:
- Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004713 | protein tyrosine kinase activity | TAS | -- |
| GO:0004872 | receptor activity | TAS | 1358805 |
| GO:0004902 | granulocyte colony-stimulating factor receptor activity | IEA | -- |
Phenotypes for CSF2RA Gene
- GenomeRNAi human phenotypes for CSF2RA:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
-
OriGene CRISPR knockouts for CSF2RA
miRNA for CSF2RA Gene
- miRTarBase miRNAs that target CSF2RA
-
- mmu-mir-466l-5p (MIRT593511)
- mmu-mir-466d-5p (MIRT593512)
- mmu-mir-466i-5p (MIRT593513)
- mmu-mir-466k (MIRT593514)
- mmu-mir-669m-5p (MIRT593515)
- mmu-mir-466m-5p (MIRT593516)
- mmu-mir-466h-5p (MIRT593517)
- mmu-mir-466n-5p (MIRT593518)
- mmu-mir-466j (MIRT593519)
- mmu-mir-3064-5p (MIRT593520)
- mmu-mir-3085-3p (MIRT593521)
miRNA Products
- Search ViGene Biosciences for CSF2RA
Inhibitory RNA Products
Clone Products
- OriGene clones in human for CSF2RA
- OriGene ORF clones in human,mouse,rat for CSF2RA
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
-
GenScript: Next-day shipping cDNA clones in your preferred vector
- NM_001161532
- NM_001161531
- NM_001161530
- NM_001161529
- NM_172249
- NM_172247
- NM_172246
- XM_011545621
- XM_011545620
- XM_011545619
- XM_011545618
- XM_011546176
- XM_011546175
- XM_011546174
- XM_011546173
- XM_011546172
- XM_011546171
- XM_011546170
- XM_011546169
- XM_011546168
- XM_011546167
- XM_011546166
- XM_011546165
- XM_011545622
- XM_011545623
- XM_011545624
- XM_011545625
- XM_011545626
- XM_011545627
- XM_011545628
- XM_011545629
- NM_006140
- NM_172245
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- R&D Systems cDNA Clones for CSF2RA (GM-CSF R alpha)
Cell Line Products
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for CSF2RA Gene
Localization for CSF2RA Gene
Subcellular locations from UniProtKB/Swiss-Prot for CSF2RA Gene
- Cell membrane; Single-pass type I membrane protein.
- Isoform 3: Secreted.
- Isoform 4: Secreted.
- Isoform 6: Secreted.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 4 |
| cytosol | 1 |
| endoplasmic reticulum | 1 |
| mitochondrion | 1 |
| nucleus | 1 |
| peroxisome | 1 |
No data available for Gene Ontology (GO) - Cellular Components for CSF2RA Gene
Pathways & Interactions for CSF2RA Gene
More details on SuperPathways for CSF2RA| Superpath | Contained pathways | ||
|---|---|---|---|
| 1 | Interleukin-3, 5 and GM-CSF signaling |
.95
|
|
| 2 | Akt Signaling |
.60
.60
|
|
| 3 | G beta-gamma signalling through PI3Kgamma | ||
| 4 | Signaling by GPCR | ||
| 5 | PEDF Induced Signaling |
.47
|
Pathways by source for CSF2RA Gene
73 Reactome pathways for CSF2RA Gene
4 KEGG pathways for CSF2RA Gene
6 Qiagen pathways for CSF2RA Gene
Interacting Proteins for CSF2RA Gene
Selected Interacting proteins:
P15509-CSF2R_HUMAN
ENSP00000394227
for CSF2RA Gene via
MINT
STRING
UniProtKB
I2D
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007173 | epidermal growth factor receptor signaling pathway | TAS | -- |
| GO:0007411 | axon guidance | TAS | -- |
| GO:0008286 | insulin receptor signaling pathway | TAS | -- |
| GO:0008543 | fibroblast growth factor receptor signaling pathway | TAS | -- |
| GO:0018108 | peptidyl-tyrosine phosphorylation | TAS | -- |
Drugs & Compounds for CSF2RA Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Sargramostim | Approved, Investigational | Pharma | binder, Target, agonist | 0 | ||
| Leukine | Approved on November 24, 1995/ Approved November 1996 | Pharma | 0 | |||
| KB002 | Investigational | Pharma | Target, Target | 0 | ||
| recombinant human GM-CSF | Investigational | Pharma | Target, Target | 0 | ||
| CG0070 | Investigational | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for CSF2RA Gene
mRNA/cDNA for CSF2RA Gene
- (34) REFSEQ mRNAs :
- (15) Additional mRNA sequences :
- (77) Selected AceView cDNA sequences:
- (20) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CSF2RA Gene
- Colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage):
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for CSF2RA
miRNA Products
- Search ViGene Biosciences for CSF2RA
Inhibitory RNA Products
Clone Products
- OriGene clones in human for CSF2RA
- OriGene ORF clones in human,mouse,rat for CSF2RA
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
-
GenScript: Next-day shipping cDNA clones in your preferred vector
- NM_001161532
- NM_001161531
- NM_001161530
- NM_001161529
- NM_172249
- NM_172247
- NM_172246
- XM_011545621
- XM_011545620
- XM_011545619
- XM_011545618
- XM_011546176
- XM_011546175
- XM_011546174
- XM_011546173
- XM_011546172
- XM_011546171
- XM_011546170
- XM_011546169
- XM_011546168
- XM_011546167
- XM_011546166
- XM_011546165
- XM_011545622
- XM_011545623
- XM_011545624
- XM_011545625
- XM_011545626
- XM_011545627
- XM_011545628
- XM_011545629
- NM_006140
- NM_172245
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- R&D Systems cDNA Clones for CSF2RA (GM-CSF R alpha)
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | · | 10c | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: |
| ExUns: | 16c |
|---|---|
| SP1: | |
| SP2: | |
| SP3: | |
| SP4: | |
| SP5: | |
| SP6: | |
| SP7: | |
| SP8: | |
| SP9: | |
| SP10: | |
| SP11: |
Expression for CSF2RA Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Inner Cell Mass (Early Embryonic Tissues)
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
- Bone (Muscoskeletal System)
- Eye (Sensory Organs)
- Adipose (Muscoskeletal System)
- Mesenchymal Stem Cells
mRNA differential expression in normal tissues according to GTEx for CSF2RA Gene
This gene is overexpressed in Whole Blood (x29.6).
This gene is overexpressed in Peripheral blood mononuclear cells (24.1), Placenta (23.6), and Monocytes (21.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CSF2RA Gene
SOURCE GeneReport for Unigene cluster for CSF2RA Gene Hs.520937
- Elite partner
Primer Products
-
OriGene qPCR primer pairs and template standards for CSF2RA
-
OriGene qPCR primer pairs for CSF2RA
No data available for mRNA Expression by UniProt/SwissProt for CSF2RA Gene
Orthologs for CSF2RA Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | LOC100336606 35 |
|
||
| CSF2RA 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | LOC609266 35 |
|
||
| CSF2RA 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Csf2ra 35 |
|
||
| Csf2ra 16 |
|
||||
| Csf2ra 36 |
|
ManyToMany | |||
| chimpanzee (Pan troglodytes) |
Mammalia | CSF2RA 35 |
|
||
| CSF2RA 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Csf2ra 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 36 |
|
OneToMany | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 36 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | CSF2RA 35 |
|
||
| -- 36 |
|
ManyToMany | |||
| -- 36 |
|
ManyToMany | |||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC101732217 35 |
|
- Species with no ortholog for CSF2RA:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for CSF2RA Gene
(1) SIMAP similar genes for CSF2RA Gene using alignment to 6 proteins:
Variants for CSF2RA Gene
| SNP ID | Clin | Chr 0X pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| VAR_058507 | Pulmonary surfactant metabolism dysfunction 4 (SMDP4) |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv29996 | CNV | Loss | 17803354 |
| esv21933 | CNV | Gain+Loss | 19812545 |
| esv2739646 | CNV | Deletion | 23290073 |
| esv2356718 | CNV | Deletion | 18987734 |
| dgv1352e201 | CNV | Deletion | 23290073 |
| esv2743274 | CNV | Deletion | 23290073 |
| esv2670322 | CNV | Deletion | 23128226 |
| esv2739653 | CNV | Deletion | 23290073 |
| esv2739654 | CNV | Deletion | 23290073 |
| esv2739655 | CNV | Deletion | 23290073 |
| esv2657055 | CNV | Deletion | 23128226 |
| esv2739656 | CNV | Deletion | 23290073 |
| esv2739657 | CNV | Deletion | 23290073 |
| esv2671552 | CNV | Deletion | 23128226 |
| esv2739658 | CNV | Deletion | 23290073 |
| esv2739659 | CNV | Deletion | 23290073 |
| dgv1353e201 | CNV | Deletion | 23290073 |
| esv2739661 | CNV | Deletion | 23290073 |
| esv2739664 | CNV | Deletion | 23290073 |
| esv2739665 | CNV | Deletion | 23290073 |
| esv2739666 | CNV | Deletion | 23290073 |
| esv2739667 | CNV | Deletion | 23290073 |
| esv2739668 | CNV | Deletion | 23290073 |
Residual Variation Intolerance Score:
87.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.64;
72.69% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for CSF2RA Gene
- Human Gene Mutation Database (HGMD)
- CSF2RA
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSF2RA Gene
Disorders for CSF2RA Gene
(10) MalaCards diseases for CSF2RA Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| surfactant metabolism dysfunction, pulmonary, 4 |
|
|
| hereditary pulmonary alveolar proteinosis |
|
|
| csf2ra-related pulmonary surfactant metabolism dysfunction |
|
|
| pulmonary surfactant metabolism dysfunction |
|
|
| acute basophilic leukemia |
|
|
Search CSF2RA in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
CSF2R_HUMAN- Pulmonary surfactant metabolism dysfunction 4 (SMDP4) [MIM:300770]: A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress. {ECO:0000269 PubMed:18955567, ECO:0000269 PubMed:18955570}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Relevant External Links for CSF2RA
No data available for Genatlas for CSF2RA Gene
Publications for CSF2RA Gene
- A functional isoform of the human granulocyte/macrophage colony- stimulating factor receptor has an unusual cytoplasmic domain. (PMID: 1715577) Crosier K.E. … Sieff C.A. (Proc. Natl. Acad. Sci. U.S.A. 1991) 3 4 23 67
- The alpha subunit of the granulocyte-macrophage colony-stimulating factor receptor interacts with c-Kit and inhibits c-Kit signaling. (PMID: 16760463) Chen J. … Golde D.W. (J. Biol. Chem. 2006) 3 23 25
- The Ig-like domain of human GM-CSF receptor alpha plays a critical role in cytokine binding and receptor activation. (PMID: 20078425) Mirza S. … Young I.G. (Biochem. J. 2010) 3 23
- A family-based study of the IL3RA gene on susceptibility to schizophrenia in a Chinese Han population. (PMID: 19281803) Sun S. … Zhang X.Y. (Brain Res. 2009) 3 23
- Converging evidence for a pseudoautosomal cytokine receptor gene locus in schizophrenia. (PMID: 17522711) Lencz T. … Malhotra A.K. (Mol. Psychiatry 2007) 3 25
Products for CSF2RA Gene
- R&D Systems Antibodies for CSF2RA (GM-CSF R alpha)
- R&D Systems Proteins and Enzymes for CSF2RA (GM-CSF R alpha)
- Browse R&D Systems for biochemical assays
- R&D Systems cDNA Clones for CSF2RA (GM-CSF R alpha)
- Browse Primary Antibodies
- Browse Proteins and Enzymes
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- Browse Activity Assays
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- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
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- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for CSF2RA
- Origene Custom Protein Services for CSF2RA
- Origene siRNA, shRNA, mouse_rna, rat_shrna, and RNAi products in human, mouse, rat for CSF2RA
- Browse OriGene Inhibitory RNA Products For CSF2RA
- OriGene qPCR primer pairs for CSF2RA
- OriGene qPCR primer pairs and template standards for CSF2RA
- OriGene CRISPR knockouts for CSF2RA
- OriGene clones in human for CSF2RA
- OriGene ORF clones in human,mouse,rat for CSF2RA
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- GenScript: Next-day shipping cDNA clones in your preferred vector
- XM_011546165
- XM_011546166
- XM_011546167
- XM_011546168
- XM_011546169
- XM_011546170
- XM_011546171
- XM_011546172
- XM_011546173
- XM_011546174
- XM_011546175
- XM_011546176
- XM_011545618
- XM_011545619
- XM_011545620
- XM_011545621
- XM_011545622
- XM_011545623
- XM_011545624
- XM_011545625
- XM_011545626
- XM_011545627
- XM_011545628
- XM_011545629
- NM_006140
- NM_172245
- NM_172246
- NM_172247
- NM_172249
- NM_001161529
- NM_001161530
- NM_001161531
- NM_001161532
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Sources for CSF2RA Gene
- (1) GeneCards
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- (8) Gene Wiki
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- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
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- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
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- (49) LSDB
- (50) BGMUT
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- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
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- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
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- (62) miRBase
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- (64) Nature
- (65) NCBI
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- (69) Salk
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- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
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- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
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- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
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- (151) Horizon