Aliases for CSF2RA Gene
Aliases for CSF2RA Gene
- Colony Stimulating Factor 2 Receptor Alpha Subunit 2 3 5
- Colony Stimulating Factor 2 Receptor, Alpha, Low-Affinity (Granulocyte-Macrophage) 2 3
- Alpha-GM-CSF Receptor 2 3
- GM-CSF-R-Alpha 3 4
- CD116 Antigen 3 4
- GMCSFR-Alpha 3 4
- GMR-Alpha 3 4
- CDw116 3 4
- CSF2RY 3 4
- CSF2R 3 4
- Granulocyte-Macrophage Colony-Stimulating Factor Receptor Subunit Alpha 3
External Ids for CSF2RA Gene
Previous HGNC Symbols for CSF2RA Gene
- CSF2R
Previous GeneCards Identifiers for CSF2RA Gene
- GC00U990072
- GC0YU900008
- GC0YM001355
- GC0XM001355
- GC0XP001347
Summaries for CSF2RA Gene
-
The protein encoded by this gene is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. This gene is found in the pseudoautosomal region (PAR) of the X and Y chromosomes. Multiple transcript variants encoding different isoforms have been found for this gene, with some of the isoforms being membrane-bound and others being soluble. [provided by RefSeq, Jul 2008]
GeneCards Summary for CSF2RA Gene
CSF2RA (Colony Stimulating Factor 2 Receptor Alpha Subunit) is a Protein Coding gene. Diseases associated with CSF2RA include Surfactant Metabolism Dysfunction, Pulmonary, 4 and Hereditary Pulmonary Alveolar Proteinosis. Among its related pathways are RET signaling and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include receptor activity and cytokine receptor activity. An important paralog of this gene is IL3RA.
UniProtKB/Swiss-Prot for CSF2RA Gene
-
Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells.
Additional gene information for CSF2RA Gene
- Monarch Initiative
- Search for CSF2RA at DataMed
- Search for CSF2RA at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSF2RA Gene
Genomics for CSF2RA Gene
GeneHancer (GH) Regulatory Elements for CSF2RA Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH0XI001268 | Promoter | 1.4 | EPDnew Ensembl | 550.8 | +0.2 | 201 | 0.4 | MXI1 MAZ USF2 MAX CEBPB SMARCB1 RFX5 POLR2A NFYB RCOR1 | CSF2RA MIR3690 | |
GH0XI001247 | Enhancer | 1.1 | FANTOM5 Ensembl | 38.7 | -19.6 | -19616 | 2.4 | MXI1 CLOCK USF1 TEAD4 MAX SIN3A ETS1 ZNF121 ZNF366 POLR2A | CSF2RA IL3RA ASMTL AKAP17A CRLF2 ASMT P2RY8 SLC25A6 | |
GH0XI001316 | Enhancer | 0.8 | FANTOM5 Ensembl | 32.2 | +47.9 | 47901 | 1 | CTCF POLR2A ZNF366 ZBTB17 | CSF2RA IL3RA ASMTL AKAP17A ASMT SLC25A6 P2RY8 CRLF2 GC0XM001318 RNA5SP498 | |
GH0XI001500 | Enhancer | 1.4 | FANTOM5 Ensembl dbSUPER | 14.6 | +234.3 | 234301 | 5 | HDGF PKNOX1 ATF1 SMAD1 IRF4 ZNF121 ZNF766 ZNF207 ATF7 RUNX3 | P2RY8 AKAP17A CSF2RA IL3RA ASMTL ASMT CRLF2 SLC25A6 | |
GH0XI001239 | Enhancer | 1 | FANTOM5 Ensembl | 17.6 | -28.9 | -28899 | 1 | BACH1 EBF1 BATF IRF4 POLR3A NFATC1 ATF7 BCLAF1 IKZF2 CREM | CSF2RA IL3RA ASMTL AKAP17A CRLF2 ASMT SLC25A6 P2RY8 |
Regulatory Element Products
Genomic Locations for CSF2RA Gene
- chrX:1,268,800-1,325,078
- (GRCh38/hg38)
- Size:
- 56,279 bases
- Orientation:
- Plus strand
- chrX:1,387,693-1,429,274
- (GRCh37/hg19)
Genomic View for CSF2RA Gene
- Cytogenetic band:
-
- Xp22.33 by Ensembl
- Xp22.33 and Yp11.2 by Entrez Gene
- Xp22.32 and Yp11.3 by HGNC


RefSeq DNA sequence for CSF2RA Gene
Proteins for CSF2RA Gene
-
Protein details for CSF2RA Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P15509-CSF2R_HUMAN
- Recommended name:
- Granulocyte-macrophage colony-stimulating factor receptor subunit alpha
- Protein Accession:
- P15509
- A7J003
- A8KAM1
- B4DW68
- J3JS76
- J3JS77
- O00207
- Q14429
- Q14430
- Q14431
- Q16564
Protein attributes for CSF2RA Gene
- Size:
- 400 amino acids
- Molecular mass:
- 46207 Da
- Quaternary structure:
-
- Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits.
- Miscellaneous:
-
- The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.
- SequenceCaution:
-
- Sequence=AAA60962.1; Type=Miscellaneous discrepancy; Evidence={ECO:0000305};
Protein Expression for CSF2RA Gene
Post-translational modifications for CSF2RA Gene
- Glycosylation at Asn46, posLast=5454, posLast=9999, posLast=123123, Asn135, Asn182, Asn195, Asn223, posLast=229229, posLast=272272, and posLast=305305
Other Protein References for CSF2RA Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- NP_001155001.1
- NP_001155002.1
- NP_001155003.1
- NP_001155004.1
- NP_006131.2
- NP_758448.1
- NP_758449.1
- NP_758450.1
- NP_758452.1
- XP_011543920.1
- XP_011543921.1
- XP_011543922.1
- XP_011543923.1
- XP_011543924.1
- XP_011543925.1
- XP_011543928.1
- XP_011543929.1
- XP_011543930.1
- XP_011544467.1
- XP_011544468.1
- XP_011544469.1
- XP_011544470.1
- XP_011544471.1
- XP_011544472.1
- XP_011544475.1
- XP_011544476.1
- XP_011544477.1
- XP_016884776.1
- XP_016884777.1
- XP_016885517.1
- XP_016885518.1
Antibody Products
- R&D Systems Antibodies for CSF2RA (GM-CSF R alpha)
-
Custom Antibody ServicesOriGene Antibodies for CSF2RA
- Novus Biologicals Antibodies for CSF2RA
-
Abcam antibodies for CSF2RA
-
Cloud-Clone Corp. Antibodies for CSF2RA
- Invitrogen Antibodies for CSF2RA
- GeneTex CSF2RA antibody for CSF2RA
-
Santa Cruz Biotechnology (SCBT) Antibodies for CSF2RA
- Sino Biological Antibodies for CSF2RA
Protein Products
- R&D Systems Proteins and Enzymes for CSF2RA (GM-CSF R alpha)
- Search Origene for MassSpec and Protein Over-expression Lysates for CSF2RA
- Origene Custom Protein Services for CSF2RA
- Sino Biological Cell Lysates for CSF2RA
- Sino Biological Recombinant Proteins for CSF2RA
- ProSpec Recombinant Proteins for CSF2RA
-
Cloud-Clone Corp. Proteins for CSF2RA
- Search GeneTex for Proteins for CSF2RA
-
ProSci Proteins for CSF2RA
-
Abcam proteins for CSF2RA
Assay Products
-
Abcam assays for CSF2RA
No data available for DME Specific Peptides for CSF2RA Gene
Domains & Families for CSF2RA Gene
Gene Families for CSF2RA Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- CD markers
- Disease related genes
- FDA approved drug targets
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for CSF2RA Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for CSF2RA Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P15509UniProtKB/Swiss-Prot:
CSF2R_HUMAN :- The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
- Belongs to the type I cytokine receptor family. Type 5 subfamily.
- Domain:
-
- The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
- The box 1 motif is required for JAK interaction and/or activation.
- Family:
-
- Belongs to the type I cytokine receptor family. Type 5 subfamily.
Function for CSF2RA Gene
Molecular function for CSF2RA Gene
- GENATLAS Biochemistry:
- colony-stimulating factor (CSF2) receptor,X-linked (granulocyte macrophage) directly intervening in the activation of JAK2 and STAT5 (JAK/STAT pathway)
- UniProtKB/Swiss-Prot Function:
- Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004713 | protein tyrosine kinase activity | TAS | -- |
GO:0004872 | receptor activity | TAS | 1358805 |
GO:0004896 | cytokine receptor activity | IEA | -- |
GO:0005088 | Ras guanyl-nucleotide exchange factor activity | TAS | -- |
GO:0005515 | protein binding | IPI | 25416956 |
Phenotypes for CSF2RA Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CSF2RA
-
- Search ViGene Biosciences for CSF2RA
CRISPR Products
-
OriGene CRISPR knockouts for CSF2RA
- genomics-online: gRNA clones - Search results for 135 available CSF2RA gene related products
- Overview of 135 available CSF2RA gene related products
- Applied Biological Materials CRISPR for CSF2RA
-
Vectors and viruses for KO, Activation, Repression, and more
miRNA for CSF2RA Gene
- miRTarBase miRNAs that target CSF2RA
-
- mmu-mir-466l-5p (MIRT593511)
- mmu-mir-466d-5p (MIRT593512)
- mmu-mir-466i-5p (MIRT593513)
- mmu-mir-466k (MIRT593514)
- mmu-mir-669m-5p (MIRT593515)
- mmu-mir-466m-5p (MIRT593516)
- mmu-mir-466h-5p (MIRT593517)
- mmu-mir-466n-5p (MIRT593518)
- mmu-mir-466j (MIRT593519)
- mmu-mir-3064-5p (MIRT593520)
- mmu-mir-3085-3p (MIRT593521)
miRNA Products
- Search ViGene Biosciences for CSF2RA
Inhibitory RNA Products
- Origene RNAi and shrna products in human, mouse, rat for CSF2RA
- Browse OriGene Inhibitory RNA Products For CSF2RA
- genomics-online: shRNA clones - Search results for 135 available CSF2RA gene related products
- Overview of 135 available CSF2RA gene related products
Clone Products
-
OriGene ORF clones in human for CSF2RA
- RG220341
- RC220341L2
- RC220341L1
- RC220341
- RG220607
- RC220607L2
- RC220607L1
- RC220607
- RG220289
- RC220289L2
- RC220289L1
- RC220289
- RG201204
- RC201204L2
- RC201204L1
- RC201204
- RG215857
- RC215857L2
- RC215857L1
- RC215857
- RG228790
- RC228790L2
- RC228790L1
- RC228790
- RG228326
- RC228326L2
- RC228326L1
- RC228326
- RG228347
- RC228347L2
- RC228347L1
- RC228347
- RG228877
- RC228877L2
- RC228877L1
- RC228877
- RC220341L2V
- RC220341L1V
- RC220607L2V
- RC220607L1V
- RC220289L2V
- RC220289L1V
- RC201204L2V
- RC201204L1V
- RC215857L2V
- RC215857L1V
- RC228790L2V
- RC228790L1V
- RC228326L2V
- RC228326L1V
- RC228347L2V
- RC228347L1V
- RC228877L2V
- RC228877L1V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
-
GenScript: Next-day shipping of latest version cDNA ORF clones for CSF2RA in any vector
- XM_011545621.1
- NM_006140.4
- XM_011545618.1
- NM_001161532.1
- NM_001161529.1
- XM_011545624.1
- XM_011546167.1
- XM_011545627.1
- XM_011546170.1
- NM_172246.2
- XM_011546173.1
- NM_001161531.1
- XM_011546176.1
- NM_172247.2
- XM_011545620.1
- XM_011545623.1
- XM_011546166.1
- XM_011545626.1
- XM_011546169.1
- XM_011545629.1
- XM_011546172.1
- NM_001161530.1
- XM_011546175.1
- NM_172245.2
- XM_011545619.1
- XM_011545622.1
- XM_011546165.1
- XM_011545625.1
- XM_011546168.1
- XM_011545628.1
- XM_011546171.1
- NM_172249.2
- XM_011546174.1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CSF2RA
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CSF2RA
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for CSF2RA
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for CSF2RA (GM-CSF R alpha)
Cell Line Products
-
Horizon Cell Lines for CSF2RA
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CSF2RA Gene
Localization for CSF2RA Gene
Subcellular locations from UniProtKB/Swiss-Prot for CSF2RA Gene
- Cell membrane; Single-pass type I membrane protein.
- Isoform 3: Secreted.
- Isoform 4: Secreted.
- Isoform 6: Secreted.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
GO:0005622 | intracellular | IEA | -- |
GO:0005886 | plasma membrane | TAS | -- |
GO:0005887 | integral component of plasma membrane | TAS | 2555171 |
GO:0016020 | membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for CSF2RA Gene
Pathways & Interactions for CSF2RA Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | RET signaling |
.92
|
.92
|
2 | Akt Signaling |
.60
.60
|
|
3 | G beta-gamma signalling through PI3Kgamma | ||
4 | Signaling by GPCR | ||
5 | PEDF Induced Signaling |
.47
|
Pathways by source for CSF2RA Gene
59 Reactome pathways for CSF2RA Gene
4 KEGG pathways for CSF2RA Gene
6 Qiagen pathways for CSF2RA Gene
Interacting Proteins for CSF2RA Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000165 | MAPK cascade | TAS | -- |
GO:0018108 | peptidyl-tyrosine phosphorylation | IEA | -- |
GO:0019221 | cytokine-mediated signaling pathway | IEA | -- |
GO:0044267 | cellular protein metabolic process | TAS | -- |
GO:0065009 | regulation of molecular function | IEA | -- |
Drugs & Compounds for CSF2RA Gene
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Sargramostim | Approved, Investigational | Pharma | Target, agonist, binder | 0 | ||
Leukine | Approved on November 24, 1995/ Approved November 1996 | Pharma | 0 | |||
KB002 | Investigational | Pharma | Target, Target | 0 | ||
recombinant human GM-CSF | Investigational | Pharma | Target, Target | 0 | ||
CG0070 | Investigational | Pharma | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
Transcripts for CSF2RA Gene
mRNA/cDNA for CSF2RA Gene
- (32) REFSEQ mRNAs :
- (15) Additional mRNA sequences :
- (77) Selected AceView cDNA sequences:
- (19) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CSF2RA Gene
- Colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage):
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for CSF2RA
- genomics-online: gRNA clones - Search results for 135 available CSF2RA gene related products
- Overview of 135 available CSF2RA gene related products
- Applied Biological Materials CRISPR for CSF2RA
-
Vectors and viruses for KO, Activation, Repression, and more
miRNA Products
- Search ViGene Biosciences for CSF2RA
Inhibitory RNA Products
- Origene RNAi and shrna products in human, mouse, rat for CSF2RA
- Browse OriGene Inhibitory RNA Products For CSF2RA
- genomics-online: shRNA clones - Search results for 135 available CSF2RA gene related products
- Overview of 135 available CSF2RA gene related products
Clone Products
-
OriGene ORF clones in human for CSF2RA
- RG220341
- RC220341L2
- RC220341L1
- RC220341
- RG220607
- RC220607L2
- RC220607L1
- RC220607
- RG220289
- RC220289L2
- RC220289L1
- RC220289
- RG201204
- RC201204L2
- RC201204L1
- RC201204
- RG215857
- RC215857L2
- RC215857L1
- RC215857
- RG228790
- RC228790L2
- RC228790L1
- RC228790
- RG228326
- RC228326L2
- RC228326L1
- RC228326
- RG228347
- RC228347L2
- RC228347L1
- RC228347
- RG228877
- RC228877L2
- RC228877L1
- RC228877
- RC220341L2V
- RC220341L1V
- RC220607L2V
- RC220607L1V
- RC220289L2V
- RC220289L1V
- RC201204L2V
- RC201204L1V
- RC215857L2V
- RC215857L1V
- RC228790L2V
- RC228790L1V
- RC228326L2V
- RC228326L1V
- RC228347L2V
- RC228347L1V
- RC228877L2V
- RC228877L1V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
-
GenScript: Next-day shipping of latest version cDNA ORF clones for CSF2RA in any vector
- XM_011545621.1
- NM_006140.4
- XM_011545618.1
- NM_001161532.1
- NM_001161529.1
- XM_011545624.1
- XM_011546167.1
- XM_011545627.1
- XM_011546170.1
- NM_172246.2
- XM_011546173.1
- NM_001161531.1
- XM_011546176.1
- NM_172247.2
- XM_011545620.1
- XM_011545623.1
- XM_011546166.1
- XM_011545626.1
- XM_011546169.1
- XM_011545629.1
- XM_011546172.1
- NM_001161530.1
- XM_011546175.1
- NM_172245.2
- XM_011545619.1
- XM_011545622.1
- XM_011546165.1
- XM_011545625.1
- XM_011546168.1
- XM_011545628.1
- XM_011546171.1
- NM_172249.2
- XM_011546174.1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CSF2RA
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CSF2RA
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for CSF2RA
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for CSF2RA (GM-CSF R alpha)
ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | · | 10c | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | · |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP9: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP11: |
ExUns: | 16c |
---|---|
SP1: | |
SP2: | |
SP3: | |
SP4: | |
SP5: | |
SP6: | |
SP7: | |
SP8: | |
SP9: | |
SP10: | |
SP11: |
Expression for CSF2RA Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Inner Cell Mass (Early Embryonic Tissues)
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
- Bone (Muscoskeletal System)
- Eye (Sensory Organs)
- Adipose (Muscoskeletal System)
- Mesenchymal Stem Cells
mRNA differential expression in normal tissues according to GTEx for CSF2RA Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CSF2RA Gene
NURSA nuclear receptor signaling pathways regulating expression of CSF2RA Gene:
CSF2RASOURCE GeneReport for Unigene cluster for CSF2RA Gene:
Hs.520937Evidence on tissue expression from TISSUES for CSF2RA Gene
- Blood(4.5)
- Bone marrow(2.4)
- Spleen(2.4)
- Lymph node(2.3)
Phenotype-based relationships between genes and organs from Gene ORGANizer for CSF2RA Gene
- ectoderm
- endoderm
- mesoderm
- cardiovascular
- digestive
- immune
- lymphatic
- respiratory
- diaphragm
- lung
- thymus
- liver
- spleen
- blood
- bone marrow
- coagulation system
- peripheral nerve
- peripheral nervous system
- red blood cell
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for CSF2RA
-
OriGene qPCR primer pairs and template standards for CSF2RA
No data available for mRNA Expression by UniProt/SwissProt for CSF2RA Gene
Orthologs for CSF2RA Gene
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | CSF2RA 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | LOC609266 33 |
|
||
CSF2RA 34 |
|
OneToOne | |||
cow (Bos Taurus) |
Mammalia | LOC100336606 33 |
|
||
CSF2RA 34 |
|
OneToOne | |||
mouse (Mus musculus) |
Mammalia | Csf2ra 33 16 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Csf2ra 33 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
OneToMany | |
platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
chicken (Gallus gallus) |
Aves | CSF2RA 33 |
|
||
-- 34 |
|
ManyToMany | |||
-- 34 |
|
ManyToMany | |||
tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC101732217 33 |
|
- Species where no ortholog for CSF2RA was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for CSF2RA Gene
(1) SIMAP similar genes for CSF2RA Gene using alignment to 6 proteins:
Variants for CSF2RA Gene
SNP ID | Clin | Chr 0X pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs137852353 | pathogenic, Surfactant metabolism dysfunction, pulmonary, 4, Pulmonary surfactant metabolism dysfunction 4 (SMDP4) [MIM:300770] | 1,290,449(+) | G/A/C | coding_sequence_variant, missense_variant, non_coding_transcript_variant | |
rs138964358 | likely-benign, benign, not specified, Surfactant metabolism dysfunction, pulmonary, 4 | 1,290,354(+) | G/A | coding_sequence_variant, missense_variant, non_coding_transcript_variant | |
rs140581875 | likely-benign, not specified, Surfactant metabolism dysfunction, pulmonary, 4 | 1,288,578(+) | A/G/T | 5_prime_UTR_variant, coding_sequence_variant, non_coding_transcript_variant, synonymous_variant | |
rs149059494 | benign, Surfactant metabolism dysfunction, pulmonary, 4 | 1,288,522(+) | A/G/T | 5_prime_UTR_variant, coding_sequence_variant, missense_variant, non_coding_transcript_variant | |
rs151058706 | benign, not specified, Surfactant metabolism dysfunction, pulmonary, 4 | 1,288,840(+) | C/T | coding_sequence_variant, missense_variant, non_coding_transcript_variant |
Additional Variant Information for CSF2RA Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSF2RA Gene
Disorders for CSF2RA Gene

(6) MalaCards diseases for CSF2RA Gene - From: HGMD, OMIM, ClinVar, Orphanet, Swiss-Prot, DISEASES, and GeneCards
Disorder | Aliases | PubMed IDs |
---|---|---|
surfactant metabolism dysfunction, pulmonary, 4 |
|
|
hereditary pulmonary alveolar proteinosis |
|
|
acute basophilic leukemia |
|
|
pulmonary alveolar proteinosis |
|
|
crest syndrome |
|
|
UniProtKB/Swiss-Prot
CSF2R_HUMAN- Pulmonary surfactant metabolism dysfunction 4 (SMDP4) [MIM:300770]: A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress. {ECO:0000269 PubMed:18955567, ECO:0000269 PubMed:18955570}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for CSF2RA
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for CSF2RA Gene
Publications for CSF2RA Gene
- A family-based study of the IL3RA gene on susceptibility to schizophrenia in a Chinese Han population. (PMID: 19281803) Sun S … Zhang XY (Brain research 2009) 3 22 44 58
- Discovery and characterization of a novel splice variant of the GM-CSF receptor alpha subunit. (PMID: 17681666) Pelley JL … Brown CB (Experimental hematology 2007) 3 4 22 58
- A functional isoform of the human granulocyte/macrophage colony-stimulating factor receptor has an unusual cytoplasmic domain. (PMID: 1715577) Crosier KE … Sieff CA (Proceedings of the National Academy of Sciences of the United States of America 1991) 3 4 22 58
- Identification and molecular cloning of a soluble human granulocyte-macrophage colony-stimulating factor receptor. (PMID: 1832774) Raines MA … Golde DW (Proceedings of the National Academy of Sciences of the United States of America 1991) 3 4 22 58
- The Ig-like domain of human GM-CSF receptor alpha plays a critical role in cytokine binding and receptor activation. (PMID: 20078425) Mirza S … Young IG (The Biochemical journal 2010) 3 22 58
Products for CSF2RA Gene
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- RC228877L1V
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- RC228347L1V
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- RC228790L1V
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- RC220289L1V
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- RC220607L1V
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- RC220341L1V
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- RC228877
- RC228877L1
- RC228877L2
- RG228877
- RC228347
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- RC228326
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- RC228790
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- RC215857
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- RC220289
- RC220289L1
- RC220289L2
- RG220289
- RC220607
- RC220607L1
- RC220607L2
- RG220607
- RC220341
- RC220341L1
- RC220341L2
- RG220341
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- XM_011545621.1
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- NM_172245.2
- XM_011546175.1
- NM_001161530.1
- XM_011546172.1
- XM_011545629.1
- XM_011546169.1
- XM_011545626.1
- XM_011546166.1
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- NM_172247.2
- XM_011546176.1
- NM_001161531.1
- XM_011546173.1
- NM_172246.2
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- XM_011545627.1
- XM_011546167.1
- XM_011545624.1
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- Sino Biological Cell Lysates for CSF2RA
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- Novus Biologicals lysates and proteins for CSF2RA
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for CSF2RA
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- Find your target
- Browse Primary Antibodies
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- ProSpec Recombinant Proteins for CSF2RA
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- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CSF2RA
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 189 available CSF2RA Antibodies ranked by validation data
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- GeneTex CSF2RA antibody for CSF2RA
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- genomics-online: cdna clones - Search results for 135 available CSF2RA gene related products
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- Overview of 135 available CSF2RA gene related products
Sources for CSF2RA Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew