Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CSF2RA Gene

protein-coding   GIFtS: 64
GCID: GC0XP001347

colony stimulating factor 2 receptor, alpha, low-affinity...


(Previous symbol: CSF2R)
 Explore 28 diseases affiliated with
CSF2RA via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CSF2RA    

Aliases
for CSF2RA gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Colony Stimulating Factor 2 Receptor, Alpha, Low-Affinity
(Granulocyte-Macrophage)1 2
     CSF2RAY2
CSF2R1 2 3     CSF2RX2
CD1161 2     GMCSFR2
CDw1162 3     GMR2
CSF2RY2 3     SMDP42
GM-CSF-R-Alpha1     Colony Stimulating Factor 2 Receptor Alpha Subunit2
GMCSFR-Alpha1     GM-CSF Receptor Alpha Subunit2
GMR-Alpha1     Granulocyte-Macrophage Colony-Stimulating Factor Receptor Alpha Chain2
CD116 Antigen2 3     Granulocyte-Macrophage Colony-Stimulating Factor Receptor Subunit Alpha2
CSF2RAX2     

External Ids:    HGNC: 24351   Entrez Gene: 14382   Ensembl: ENSG000001982237   OMIM: 3062505   UniProtKB: P155093   
ORGUL members:         
NONCODE:n408005    

Export aliases for CSF2RA gene to outside databases

Previous GC identifers: GC00U990072 GC0YU900008 GC0YM001355 GC0XM001355


Summaries
for CSF2RA gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CSF2RA:
The protein encoded by this gene is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a
cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded
protein is a member of the cytokine family of receptors. This gene is found in the pseudoautosomal region (PAR) of the
X and Y chromosomes. Multiple transcript variants encoding different isoforms have been found for this gene, with some
of the isoforms being membrane-bound and others being soluble. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CSF2R_HUMAN, P15509
Function: Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results
in the proliferation, differentiation, and functional activation of hematopoietic cells

Gene Wiki entry for CSF2RA (Granulocyte macrophage colony-stimulating factor receptor)


Genomic Views
for CSF2RA gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_000024.9  NC_018934.1  NT_167196.1  NT_167204.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CSF2RA gene promoter:
         Max1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CSF2RA promoter sequence
   Search SABiosciences Chromatin IP Primers for CSF2RA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CSF2RA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.32 and Yp11.3   Ensembl cytogenetic band:  Xp22.33   HGNC cytogenetic band: Xp22.32 and Yp11.3

CSF2RA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CSF2RA gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP001347:  view genomic region     (about GC identifiers)

Start:
 1,387,693 bp from pter      End:
 1,429,274 bp from pter
Size:
 41,582 bases      Orientation:
 plus strand

1 alternative location:
ChrY+ 1,337,693-1,378,828     

Proteins
for CSF2RA gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CSF2R_HUMAN, P15509 (See protein sequence)
Recommended Name: Granulocyte-macrophage colony-stimulating factor receptor subunit alpha precursor  
Size: 400 amino acids; 46207 Da
Subunit: Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors.
The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two
ligand subunits
Subcellular location: Cell membrane; Single-pass type I membrane protein
Subcellular location: Isoform 3: Secreted (Probable)
Subcellular location: Isoform 4: Secreted (Probable)
Subcellular location: Isoform 6: Secreted (Probable)
Miscellaneous: The gene encoding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y
chromosomes
1 PDB 3D structure from and Proteopedia for CSF2RA:
3CXE (3D)    
Secondary accessions: A7J003 A8KAM1 B4DW68 J3JS76 O00207 Q14429 Q14430 Q14431 Q16564
Alternative splicing: 8 isoforms:  P15509-1   P15509-2   P15509-3   P15509-4   P15509-5   P15509-6   P15509-7   P15509-8   

Explore the universe of human proteins at neXtProt for CSF2RA: NX_P15509

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P15509

    • CSF2RA Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (9 alternative transcripts): 
    NP_001155001.1  NP_001155002.1  NP_001155003.1  NP_001155004.1  NP_006131.2  NP_758448.1  NP_758449.1  NP_758450.1  
    NP_758452.1  

    ENSEMBL proteins: 
     ENSP00000370940   ENSP00000370935   ENSP00000410667   ENSP00000397452   ENSP00000370920  
     ENSP00000348058   ENSP00000436825   ENSP00000347606   ENSP00000370911   ENSP00000416437  
     ENSP00000394227   ENSP00000354836   ENSP00000440491  
    Reactome Protein details: P15509
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CSF2RA (GM-CSF R alpha)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins (see all 4): CSF2RA
    OriGene Protein Over-expression Lysate (see all 7): CSF2RA
    OriGene Custom Protein Services for CSF2RA 
    GenScript Custom Purified and Recombinant Proteins Services for CSF2RA
    Novus Biologicals CSF2RA Proteins
    Novus Biologicals CSF2RA Lysates
    Sino Biological Recombinant Protein for CSF2RA
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS2555171
    GO:0016020membrane ----


    CSF2RA for ontologies           About GeneDecksing



    CSF2RA Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CSF2RA
    R&D Systems Antibodies for CSF2RA (GM-CSF R alpha)
    OriGene Antibodies: CSF2RA
    OriGene Custom Antibody Services for CSF2RA 
    GenScript Custom Superior Antibodies Services for CSF2RA
    Novus Biologicals CSF2RA Antibodies
    Abcam antibodies for CSF2RA 
    Browse Antibodies at Uscn
    Search ThermoFisher Antibodies for CSF2RA

    Assay Products for CSF2RA: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CSF2RA
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for CSF2RA gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CSF2RA for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR015321 IL6_recept-bd
     IPR003961 Fibronectin_type3
     IPR013783 Ig-like_fold
     IPR003532 Short_hematopoietin_rcpt_2_CS

    Graphical View of Domain Structure for InterPro Entry P15509

    ProtoNet protein and cluster: P15509

    1 Blocks protein family: IPB003532 Short hematopoietin receptor

    UniProtKB/Swiss-Prot: CSF2R_HUMAN, P15509
    Domain: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular
    transport and cell-surface receptor binding
    Domain: The box 1 motif is required for JAK interaction and/or activation
    Similarity: Belongs to the type I cytokine receptor family. Type 5 subfamily


    Function
    for CSF2RA gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CSF2R_HUMAN, P15509
    Function: Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results
    in the proliferation, differentiation, and functional activation of hematopoietic cells

         Genatlas biochemistry entry for CSF2RA:
    colony-stimulating factor (CSF2) receptor,X-linked (granulocyte macrophage) directly intervening in the activation of
    JAK2 and STAT5 (JAK/STAT pathway)

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 9): CSF2RA
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CSF2RA
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CSF2RA
    SwitchGear 3'UTR luciferase reporter plasmid: CSF2RA 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CSF2RA
    OriGene shRNA RFP: CSF2RA
    OriGene siRNA: CSF2RA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CSF2RA

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CSF2RA

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CSF2RA (see all 9)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CSF2RA (see all 9)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 9): CSF2RA (NM_006140)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CSF2RA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSF2RA 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for CSF2RA
    Search LifeMap BioReagents cell lines for CSF2RA

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSF2RA

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity TAS1358805
    GO:0004896cytokine receptor activity IEA--


    CSF2RA for ontologies           About GeneDecksing



    Pathways & Interactions
    for CSF2RA gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Interleukin receptor SHC signaling
    		Interleukin receptor SHC signaling1.00
    		Interleukin-3, 5 and GM-CSF signaling0.57
    		Interleukin-2 signaling0.67
    		The receptor is activated0.29
    		Phosphorylated SHC1 recruits GRB2:GAB20.61
    		Signaling by Interleukins0.25
    		SHC1 mediates cytokine-induced phosphorylation of GAB20.61
    2Akt Signaling
    		Akt Signaling1.00
    		Tec Kinases Signaling0.55
    		p38 Signaling0.60
    3PEDF Induced Signaling
    		STAT3 Pathway0.47
    		Cytokine-cytokine receptor interaction0.26
    4Cytokine Signaling in Immune system
    		Cytokine Signaling in Immune system1.00
    5Immune System
    		Immune System1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for CSF2RA
        Selected targets of C/EBPalpha

    5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CSF2RA (see all 6)
        STAT3 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    p38 Signaling
    Akt Signaling

    5/9        Reactome Pathways for CSF2RA (see all 9)
        SHC1 mediates cytokine-induced phosphorylation of GAB2
    Interleukin receptor SHC signaling
    Interleukin-2 signaling
    Phosphorylated SHC1 recruits GRB2:GAB2
    Cytokine Signaling in Immune system


    4         Kegg Pathways  (Kegg details for CSF2RA):
        Cytokine-cytokine receptor interaction
    Jak-STAT signaling pathway
    Hematopoietic cell lineage
    Pathways in cancer


    CSF2RA for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CSF2RA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/40 Interacting proteins for CSF2RA (P155092, 3 ENSP000003709354) via UniProtKB, MINT, STRING, and/or I2D (see all 40)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIK3R1P279862, 3, ENSP000002743354MINT-8111763 I2D: score=5 STRING: ENSP00000274335
    CHUKO151113, ENSP000003594244I2D: score=2 STRING: ENSP00000359424
    CSF2RBP329273, ENSP000003840534I2D: score=2 STRING: ENSP00000384053
    RPSAP088653, ENSP000003460674I2D: score=1 STRING: ENSP00000346067
    CSF2P041413, ENSP000002968714I2D: score=3 STRING: ENSP00000296871
    About this table

    Drugs & Compounds
    for CSF2RA gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CSF2RA for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CSF2RA

    1 DrugBank Compound for CSF2RA    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    SargramostimColony-stimulating factor (see all 5)83869-56-1targetagonist17090651 11752352 16638185 16760463 17522711

    4 Novoseek chemical compound relationships for CSF2RA gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gp 130 40.8 2 11306493 (1), 9675079 (1)
    tyrosine 38.1 5 8298195 (2), 11698308 (1), 9389692 (1)
    serine 5.53 2 1715577 (1)
    glucose 0 3 7849318 (1), 7696970 (1)

    Search CenterWatch for drugs/clinical trials and news about CSF2RA / CSF2R 

    Transcripts
    for CSF2RA gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CSF2RA gene (10 alternative transcripts): 
    NM_001161529.1  NM_001161530.1  NM_001161531.1  NM_001161532.1  NM_006140.4  NM_172245.2  NM_172246.2  NM_172247.2  
    NM_172249.2  NM_172248.1  

    Unigene Cluster for CSF2RA:

    Colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
    Hs.520937  [show with all ESTs]
    Unigene Representative Sequence: NM_001161529
    18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000381529 ENST00000381524(uc004cpn.2 uc010ncu.2) ENST00000493312
    ENST00000412290 ENST00000419094 ENST00000381509(uc011mhb.1) ENST00000494969
    ENST00000481245 ENST00000355805 ENST00000486791 ENST00000355432 ENST00000381500
    ENST00000477940 ENST00000478256 ENST00000475259 ENST00000491683 ENST00000498153
    ENST00000432318(uc010nct.2 uc004cpo.2)

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 9): CSF2RA
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CSF2RA
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CSF2RA
    SwitchGear 3'UTR luciferase reporter plasmid: CSF2RA 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CSF2RA
    OriGene shRNA RFP: CSF2RA
    OriGene siRNA: CSF2RA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CSF2RA
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CSF2RA (see all 9)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CSF2RA (see all 9)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 9): CSF2RA (NM_006140)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CSF2RA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSF2RA 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CSF2RA
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CSF2RA
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CSF2RA
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CSF2RA

    Additional cDNA sequence: 

    AK293086.1 AK301395.1 AK309630.1 AL833597.1 BC002635.1 BC071835.1 DQ841258.1 L29348.1 
    L29349.1 M64445.1 M73832.1 NR_027760.1 U93096.1 X17648.1 X54935.1 

    24/28 DOTS entries (see all 28):

    DT.454155  DT.86853517  DT.100819891  DT.120651231  DT.100819887  DT.100819889  DT.100023263  DT.100819894 
    DT.91680973  DT.91903275  DT.120651257  DT.121277687  DT.40105950  DT.92424763  DT.95162396  DT.95201746 
    DT.120651247  DT.95162394  DT.100800368  DT.100819897  DT.120651235  DT.121277672  DT.121277688  DT.86837287 

    24/77 AceView cDNA sequences (see all 77):

    BG477733 L29348 BX324688 X17648 NM_172249 NM_006140 NM_172247 U93096 
    BC002635 BX397893 L29349 CA426022 BE391340 NM_172246 BX336385 BX336675 
    X54935 AL542941 M73832 BX459288 NM_172248 CD366453 NM_172245 CA748605 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for CSF2RA (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ·
    SP1:                          -     -                       -                                   -                       -                       -               
    SP2:                                -     -                 -                                   -                       -                                       
    SP3:                                -     -                 -                                   -                       -                       -               
    SP4:                          -     -     -                 -                                   -                       -                       -               
    SP5:                                -     -                 -                                   -                       -     -                 -               

    ExUns: 16c
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for CSF2RA

    Expression
    for CSF2RA gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CSF2RA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See CSF2RA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CSF2RA

    SOURCE GeneReport for Unigene cluster: Hs.520937
        SABiosciences Expression via Pathway-Focused PCR Arrays including CSF2RA: 
              Interferons & Receptors in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CSF2RA
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CSF2RA
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CSF2RA
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CSF2RA
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSF2RA

    Orthologs
    for CSF2RA gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for CSF2RA gene from 1/7 species (see all 7)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CSF2RA1 granulocyte-macrophage colony-stimulating factor receptor more 48.15(n)
    35.93(a)    		   418667  XM_416863.2  XP_416863.1 


    ENSEMBL Gene Tree for CSF2RA (if available)
    TreeFam Gene Tree for CSF2RA (if available) 

    Paralogs
    for CSF2RA gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CSF2RA gene
    IL3RA2  
    1 SIMAP similar gene for CSF2RA using alignment to 6 protein entries:     CSF2R_HUMAN (see all proteins):
    IL3RA

    CSF2RA for paralogs           About GeneDecksing



    Genomic Variants
    for CSF2RA gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 8 variations for CSF2RA
         7 CNVs: 83897 73903 73906 67929 73905 97145 97146
         1 Indel: 47768
    Human Gene Mutation Database (HGMD): CSF2RA

    Locus Specific Mutation Databases (LSDB): CSF2RA
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CSF2RA
    DNA2.0 Custom Variant and Variant Library Synthesis for CSF2RA

    Disorders / Diseases
    for CSF2RA gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CSF2RA for disorders           About GeneDecksing

    OMIM gene information: 306250   
    OMIM disorders: 300770  
    UniProtKB/Swiss-Prot: CSF2R_HUMAN, P15509
  • Defects in CSF2RA are the cause of pulmonary surfactant metabolism dysfunction type 4 (SMDP4) [MIM:300770]. A
    • rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular
    material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and
    protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress

    20/28 diseases for CSF2RA (see all 28):    About MalaCards
    interleukin-7 receptor alpha deficiency    pulmonary surfactant metabolism dysfunction    pulmonary alveolar proteinosis    x inactivation
    myeloid leukemia    aplastic anemia    inflammatory bowel disease    atopic dermatitis
    acute myeloid leukemia    chronic myeloid leukemia    respiratory failure    cblc
    diphtheria    myelodysplastic syndrome    dermatitis    leukemia
    prostate cancer    endometrial cancer    anemia    choriocarcinoma

    2 diseases from the University of Copenhagen DISEASES database for CSF2RA:
    Pulmonary alveolar proteinosis     Leukemia

    7 Novoseek disease relationships for CSF2RA gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia 40.2 5 7934175 (2), 9332306 (1), 11238105 (1), 8418381 (1)
    myeloid leukemia chronic 23.8 1 9131005 (1)
    leukemia lymphocytic chronic 10.8 1 8695795 (1)
    cancer 3.13 1 15497703 (1)
    necrosis 0 3 9328452 (1), 9389700 (1)
    tumors 0 5 7849318 (1), 9328452 (1), 9389700 (1)
    prostate cancer 0 1 8687098 (1)

    Human Genome Epidemiology (HuGE) Navigator: CSF2RA (3 documents)

    Export disorders for CSF2RA gene to outside databases

    Publications
    for CSF2RA gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CSF2RA gene, integrated from 9 sources (see all 158):
    (articles sorted by number of sources associating them with CSF2RA)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A functional isoform of the human granulocyte/macrophage colony- stimulating factor receptor has an unusual cytoplasmic domain. (PubMed id 1715577)1, 2, 9 Crosier K.E.... Sieff C.A. (1991)
    2. Discovery and characterization of a novel splice variant of the GM-CSF receptor alpha subunit. (PubMed id 17681666)1, 2, 9 Pelley J.L....Brown C.B. (2007)
    3. The alpha subunit of the granulocyte-macrophage colony-stimulating factor receptor interacts with c-Kit and inhibits c-Kit signaling. (PubMed id 16760463)1, 7, 9 Chen J....Golde D.W. (2006)
    4. Identification and molecular cloning of a soluble human granulocyte- macrophage colony-stimulating factor receptor. (PubMed id 1832774)1, 2, 9 Raines M.A.... Golde D.W. (1991)
    5. Pulmonary alveolar proteinosis caused by deletion of the GM-CSFRalpha gene in the X chromosome pseudoautosomal region 1. (PubMed id 18955567)1, 2 Martinez-Moczygemba M....Huston D.P. (2008)
    6. The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation. (PubMed id 18692472)1, 2 Hansen G....Parker M.W. (2008)
    7. Familial pulmonary alveolar proteinosis caused by mutations in CSF2RA. (PubMed id 18955570)1, 2 Suzuki T....Trapnell B.C. (2008)
    8. Converging evidence for a pseudoautosomal cytokine receptor gene locus in schizophrenia. (PubMed id 17522711)1, 7 Lencz T....Malhotra A.K. (2007)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Structure of the gene encoding the alpha subunit of the human granulocyte-macrophage colony stimulating factor receptor. Implications for the evolution of the cytokine receptor superfamily. (PubMed id 8144676)1, 2 Nakagawa Y.... Yokota T. (1994)

    External Searches for CSF2RA gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CSF2RA gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1438 HGNC: 2435 AceView: CSF2RA.1 Ensembl:ENSG00000198223 euGenes: HUgn1438
    ECgene: CSF2RA Kegg: 1438 H-InvDB: CSF2RA

    Other Databases showing CSF2RA gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CSF2RA gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CSF2RA Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CSF2RA Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for CSF2RA gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CSF2RA gene:
    Search GeneIP for patents involving CSF2RA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for CSF2RA gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     EMD Millipore Mono- and Polyclonal Antibodies for the study of CSF2RA
     Browse Small Molecules at EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for CSF2RA (GM-CSF R alpha)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins for CSF2RA (GM-CSF R alpha)  
     OriGene Antibodies for CSF2RA   OriGene shRNA RFP for CSF2RA  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CSF2RA   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CSF2RA  
     OriGene Protein Over-expression Lysate for CSF2RA   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for CSF2RA   OriGene 3'-UTR Clone for CSF2RA  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CSF2RA   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CSF2RA  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for CSF2RA   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CSF2RA   OriGene Custom Protein Services for CSF2RA  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CSF2RA
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CSF2RA
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CSF2RA
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CSF2RA
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CSF2RA
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CSF2RA
     GenScript Custom Purified and Recombinant Proteins Services for CSF2RA GenScript cDNA clones with any tag delivered in your preferred vector for CSF2RA
     GenScript Custom Assay Services for CSF2RA GenScript Custom Superior Antibodies Services for CSF2RA
     GenScript Custom overexpressing Cell Line Services for CSF2RA CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CSF2RA promoter
     Search Chromatin IP Primers for CSF2RA
     RT2 qPCR Primer Assay in human, mouse, rat CSF2RA
     GNC Network for CSF2RA
     SABiosciences PCR Arrays including human, mouse, rat CSF2RA
     Search Tocris compounds for CSF2RA
     Proteins and Antibodies for CSF2RA
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CSF2RA antibodies
     CSF2RA proteins
     CSF2RA lysates
     Antibodies for CSF2RA
     See all of Abcam's Antibodies, Kits and Proteins for CSF2RA
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn
     Search LifeMap BioReagents cell lines for CSF2RA
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSF2RA
     SwitchGear 3'UTR luciferase reporter plasmids for CSF2RA
     SwitchGear Promoter luciferase reporter plasmids for CSF2RA
     Search ThermoFisher Antibodies for CSF2RA
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSF2RA
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      CSF2RA gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4