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CSF2 Gene

protein-coding   GIFtS: 65
GCID: GC05P131409

Colony Stimulating Factor 2 (Granulocyte-Macrophage)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Colony Stimulating Factor 2 (Granulocyte-Macrophage)1 2     Granulocyte-Macrophage Colony-Stimulating Factor2
GMCSF2 3 5     GM-CSF3
molgramostin1 2     Molgramostin3
sargramostim1 2     Sargramostim3
CSF2 3     Colony-Stimulating Factor3
Granulocyte-Macrophage Colony Stimulating Factor1     

External Ids:    HGNC: 24341   Entrez Gene: 14372   Ensembl: ENSG000001644007   OMIM: 1389605   UniProtKB: P041413   

Export aliases for CSF2 gene to outside databases

Previous GC identifers: GC05P130931 GC05P131856 GC05P131440 GC05P131485 GC05P131437 GC05P126601


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CSF2 Gene:
The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of
granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene
has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with
interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include
those encoding interleukins 4, 5, and 13. (provided by RefSeq, Jul 2008)

GeneCards Summary for CSF2 Gene:
CSF2 (colony stimulating factor 2 (granulocyte-macrophage)) is a protein-coding gene. Diseases associated with CSF2 include acquired agranulocytosis, and ecthyma. GO annotations related to this gene include granulocyte macrophage colony-stimulating factor receptor binding and cytokine activity.

UniProtKB/Swiss-Prot: CSF2_HUMAN, P04141
Function: Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various
lineages, including granulocytes, macrophages, eosinophils and erythrocytes

Gene Wiki entry for CSF2 (Granulocyte macrophage colony-stimulating factor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NC_018916.2  NT_034772.7  
Regulatory elements:
   Regulatory transcription factor binding sites in the CSF2 gene promoter:
         AML1a   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CSF2 promoter sequence
   Search Chromatin IP Primers for CSF2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CSF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.1   Ensembl cytogenetic band:  5q31.1   HGNC cytogenetic band: 5q23-q31

CSF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CSF2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P131409:  view genomic region     (about GC identifiers)

Start:
131,409,483 bp from pter      End:
131,411,859 bp from pter
Size:
2,377 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CSF2_HUMAN, P04141 (See protein sequence)
Recommended Name: Granulocyte-macrophage colony-stimulating factor precursor  
Size: 144 amino acids; 16295 Da
Subunit: Monomer. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha,
two beta, and two ligand subunits
3 PDB 3D structures from and Proteopedia for CSF2:
1CSG (3D)        2GMF (3D)        3CXE (3D)    
Secondary accessions: Q14CE8 Q2VPI8 Q8NFI6

Explore the universe of human proteins at neXtProt for CSF2: NX_P04141

Explore proteomics data for CSF2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Ser22, Ser24, Ser26, Thr27, Asn44, Asn54

  • See CSF2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000749.2  
    ENSEMBL proteins: 
     ENSP00000296871  
    Reactome Protein details: P04141

    CSF2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CSF2 (GM-CSF)
    Enzo Life Sciences proteins for CSF2
    OriGene Purified Proteins for CSF2
    OriGene Protein Over-expression Lysate for CSF2
    OriGene MassSpec for CSF2
    OriGene Custom Protein Services for CSF2
    GenScript Purified and Recombinant Proteins for CSF2
    Novus Biologicals CSF2 Proteins
    Novus Biologicals CSF2 Lysates
    Sino Biological Recombinant Protein for CSF2
    Sino Biological Cell Lysate for CSF2
    ProSpec Recombinant Protein for CSF2
    Browse Proteins at Cloud-Clone Corp.

    CSF2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CSF2 (GM-CSF)
    OriGene Antibodies for CSF2
    OriGene Custom Antibody Services for CSF2
    Novus Biologicals CSF2 Antibodies
    Abcam antibodies for CSF2
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for CSF2
    LSBio Antibodies in human, mouse, rat for CSF2

    CSF2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CSF2
    R&D Systems Flow Cytometry Kits for CSF2 (GM-CSF)         (see all)
    GenScript Custom Assay Services for CSF2
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR012351 4_helix_cytokine_core
     IPR000773 GM_colony-stim-fac
     IPR009079 4_helix_cytokine-like_core

    Graphical View of Domain Structure for InterPro Entry P04141

    ProtoNet protein and cluster: P04141

    1 Blocks protein domain: IPB000773 Granulocyte-macrophage colony-stimulating factor

    UniProtKB/Swiss-Prot: CSF2_HUMAN, P04141
    Similarity: Belongs to the GM-CSF family


    CSF2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CSF2_HUMAN, P04141
    Function: Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various
    lineages, including granulocytes, macrophages, eosinophils and erythrocytes

         Genatlas biochemistry entry for CSF2:
    colony-stimulating factor 2,16.3kDa,(granulocyte-macrophage)

         Summary: 
    CSF2 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
                fully expand
    Blood: Immature dendritic-like cells, Mature dendritic-like cells      fully expand to see all 3 cells
    and also in: Expanded hematopoieic cells, Expanded hematopoieic cells

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IEA--
    GO:0005129granulocyte macrophage colony-stimulating factor receptor binding IEA--
    GO:0005515protein binding IPI18692472
    GO:0008083growth factor activity IEA--
         
    CSF2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CSF2:
     Increased cell death HMECs cel  Increased cell death in breast 

         Selected MGI mutant phenotypes (inferred from 4 alleles(MGI details for Csf2) (see all 19):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  craniofacial 
     embryogenesis  endocrine/exocrine gland  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  integument  mortality/aging  other  renal/urinary system 

    CSF2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CSF2: Csf2tm1Mlg Csf2tm1Dran

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CSF2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CSF2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CSF2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CSF2

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat CSF2 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate CSF2:
    hsa-miR-410
    SwitchGear 3'UTR luciferase reporter plasmidCSF2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CSF2
    Predesigned siRNA for gene silencing in human, mouse, rat CSF2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CSF2

    Clone
    Products:
         
    OriGene clones in human, mouse for CSF2 (see all 9)
    OriGene ORF clones in mouse, rat for CSF2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CSF2 (NM_000758)
    Sino Biological Human cDNA Clone for CSF2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CSF2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSF2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CSF2
    Browse ESI BIO Cell Lines and PureStem Progenitors for CSF2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSF2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CSF2_HUMAN, P04141: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus3
    plasma membrane3
    cytoskeleton2
    cytosol2
    lysosome2
    vacuole2
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--

    CSF2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CSF2 About   (see all 24)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Regulation of Innate Immune Cells0.94
    IL-6 Pathway0.61
    MIF Mediated Glucocorticoid Regulation0.94
    STAT3 Pathway0.47
    PEDF Induced Signaling0.73
    Endothelin-1 Signaling Pathway0.46
    all-trans-Retinoic Acid Signaling in Brain0.71
    Cytokine-cytokine receptor interaction0.43
    2Immune response Role of DAP12 receptors in NK cells
    Immune response CD16 signaling in NK cells0.33
    Natural killer cell mediated cytotoxicity0.31
    3Signaling by Interleukins
    Interleukin receptor SHC signaling0.67
    Interleukin-3, 5 and GM-CSF signaling0.59
    Interleukin-2 signaling0.67
    Signaling by Interleukins0.42
    4ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    5Cytokine production by Th17 cells in CF
    Cytokine production by Th17 cells in CF0.72
    Cytokine production by Th17 cells in CF Mouse model 0.72

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CSF2
        IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CSF2 (see all 15)
        MIF Regulation of Innate Immune Cells
    STAT3 Pathway
    Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C

    3 GeneGo (Thomson Reuters) Pathways for CSF2
        Immune response CD16 signaling in NK cells
    Cytokine production by Th17 cells in CF (Mouse model)
    Cytokine production by Th17 cells in CF

    Selected BioSystems Pathways for CSF2 (see all 6)
        Cytokines and Inflammatory Response
    Calcium signaling in the CD4+ TCR pathway
    Calcineurin-regulated NFAT-dependent transcription in lymphocytes
    Syndecan-2-mediated signaling events
    Glucocorticoid receptor regulatory network


    2 Reactome Pathways for CSF2
        Interleukin receptor SHC signaling
    Interleukin-3, 5 and GM-CSF signaling


    Selected Kegg Pathways  (Kegg details for CSF2) (see all 12):
        Cytokine-cytokine receptor interaction
    Jak-STAT signaling pathway
    Hematopoietic cell lineage
    Natural killer cell mediated cytotoxicity
    T cell receptor signaling pathway


    CSF2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CSF2 (see all 25): 
              Interferons & Receptors in human mouse rat
              Wound Healing in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Th17 Response in human mouse rat
              Mesenchymal Stem Cell in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CSF2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CSF2 (P041411, 3 ENSP000002968714) via UniProtKB, MINT, STRING, and/or I2D (see all 51)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSF2RBP329271, 3, ENSP000003840534EBI-1809826,EBI-1809771 I2D: score=3 STRING: ENSP00000384053
    CSF2RAP155093, ENSP000003709354I2D: score=3 STRING: ENSP00000370935
    IL3RAP269513, ENSP000003278904I2D: score=2 STRING: ENSP00000327890
    PRG2P137273, ENSP000003121344I2D: score=2 STRING: ENSP00000312134
    KITLGP215833, ENSP000002282804I2D: score=1 STRING: ENSP00000228280
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001892embryonic placenta development IEA--
    GO:0006955immune response IEA--
    GO:0008284positive regulation of cell proliferation IEA--
    GO:0010468regulation of gene expression ----
    GO:0010628positive regulation of gene expression IDA10666185

    CSF2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CSF2

    UniProtKB/Swiss-Prot: CSF2_HUMAN, P04141
    Pharmaceutical: Available under the names Leukine (Immunex) and Leucomax (Novartis). Used in myeloid
    reconstitution following bone marrow transplant, bone marrow transplant engraftment failure or delay,
    mobilization and following transplantation of autologous peripheral blood progenitor cells, and following
    induction chemotherapy in older adults with acute myelogenous leukemia

    Selected Novoseek inferred chemical compound relationships for CSF2 gene (see all 145)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gm-csf 94.5 394 1423182 (11), 1854591 (10), 18782657 (8), 9832332 (8) (see all 99)
    pixy321 79 21 1383918 (3), 8405227 (2), 9816121 (2), 9490056 (2) (see all 14)
    molgramostim 77.1 8 7781752 (1), 8158688 (1), 9124202 (1), 7579383 (1) (see all 8)
    fmlp 71 53 15107457 (2), 9427721 (2), 10419502 (2), 1382715 (1) (see all 42)
    rantes 66.6 62 9003213 (2), 8757214 (2), 8998072 (2), 10792507 (1) (see all 56)
    n-formylmethionyl-leucylphenylalanine 65.4 19 2123794 (1), 8144533 (1), 7679062 (1), 1281785 (1) (see all 17)
    methylcellulose 62.8 11 1903073 (1), 1518302 (1), 9238762 (1), 11369665 (1) (see all 11)
    filgrastim 62.6 30 7683736 (2), 16258470 (2), 8074347 (1), 9142195 (1) (see all 23)
    provenge 60.1 4 11099318 (1), 17696825 (1), 17362049 (1)
    cytarabine 59.9 46 1737098 (2), 14984497 (2), 1553573 (2), 1593908 (2) (see all 33)



    CSF2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CSF2 gene: 
    NM_000758.3  

    Unigene Cluster for CSF2:

    Colony stimulating factor 2 (granulocyte-macrophage)
    Hs.1349  [show with all ESTs]
    Unigene Representative Sequence: BE873976
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000296871(uc003kwf.3)
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate CSF2:
    hsa-miR-410
    SwitchGear 3'UTR luciferase reporter plasmidCSF2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CSF2
    Predesigned siRNA for gene silencing in human, mouse, rat CSF2
    Clone
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    OriGene clones in human, mouse for CSF2 (see all 9)
    OriGene ORF clones in mouse, rat for CSF2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CSF2 (NM_000758)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CSF2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSF2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CSF2
    OriGene qSTAR qPCR primer pairs in human, mouse for CSF2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CSF2
      QuantiTect SYBR Green Assays in human, mouse, rat CSF2
      QuantiFast Probe-based Assays in human, mouse, rat CSF2

    Additional mRNA sequence: 

    AF510855.1 AY720441.1 BC108724.1 BC113924.1 BC113999.1 M10663.1 M11220.1 M11734.1 

    1 DOTS entry:

    DT.110709 

    20 AceView cDNA sequences:

    NM_000758 T29160 BU633411 CD367244 M10663 CA307828 BV202503 M11220 
    AY720441 M11734 AI655452 AF510855 CD368851 CD369973 BE873976 BG236310 
    CA309134 AW951121 AI677936 AA361936 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CSF2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGGAGTGG
    CSF2 Expression
    About this image


    CSF2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Fibroblasts
             Dermal Fibroblasts Dorsal Dermis
     
     Dermis (Integumentary System)    fully expand to see all 3 entries
             Dermal Fibroblasts Dorsal Dermis
     
     NULL (Uncategorized)
             Adipose-derived stromal vascular fraction and adipocytes (HiQCell)
     
     Heart (Cardiovascular System)
             Mature Cardiac Fibroblasts Myocardium
     
     Testis (Reproductive System)
             Sertoli cells Seminiferous Tubules
    CSF2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CSF2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.1349
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CSF2 (see all 25): 
              Interferons & Receptors in human mouse rat
              Wound Healing in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Th17 Response in human mouse rat
              Mesenchymal Stem Cell in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CSF2
    OriGene qSTAR qPCR primer pairs in human, mouse for CSF2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CSF2
    QuantiTect SYBR Green Assays in human, mouse, rat CSF2
    QuantiFast Probe-based Assays in human, mouse, rat CSF2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSF2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for CSF2 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Csf21 , 5 colony stimulating factor 2 (granulocyte-macrophage)1, 5 71.16(n)1
    56.03(a)1
      11 (32.13 cM)5
    129811  NM_009969.41  NP_034099.21 
     542472715 


    ENSEMBL Gene Tree for CSF2 (if available)
    TreeFam Gene Tree for CSF2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    CSF2_HUMAN, P04141: Variant Ile-117 may be a risk factor for atopic asthma


    Selected SNPs for CSF2 (see all 117)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs20696281,2
    C,F--131410901(+) GGTGAG/-GGCAA 1 -- int13Minor allele frequency- -:0.09NS NA 96
    rs799702731,2
    C,F--131683011(+) CTGGAC/TTTCCC 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs47059161,2
    C,F,A,H--131683014(+) GACTTC/ACCCCT 1 -- us2k1 tfbs39Minor allele frequency- A:0.18NA NS EA WA 674
    rs1438582701,2
    --131683023(+) CTGCCA/GAGTCA 1 -- us2k10--------
    rs20696141,2
    C,F,O,A,H--131683122(+) CCGTTT/CACCTC 1 -- us2k121Minor allele frequency- C:0.31NS EA NA WA CSA 2296
    rs20696351,2
    C,F,H--131683195(+) CTCATT/CTCTAG 1 -- us2k17Minor allele frequency- C:0.00NS EA 688
    rs1128400121,2
    F--131683365(+) CCCCCG/AAGAGC 1 -- us2k12Minor allele frequency- A:0.03CSA WA 120
    rs1151939921,2
    C,F--131683389(+) CTGAGC/TCAAGG 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1472365361,2
    --131683570(+) GTACAC/GGGAAA 1 -- us2k10--------
    rs20696151,2
    C,F--131683586(+) CAGGGC/TTGCAG 1 -- us2k14Minor allele frequency- T:0.01NS EA WA 388

    HapMap Linkage Disequilibrium report for CSF2 (131409483 - 131411859 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CSF2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv882889CNV Loss21882294
    esv25745CNV Gain19812545

    Human Gene Mutation Database (HGMD): CSF2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CSF2
    DNA2.0 Custom Variant and Variant Library Synthesis for CSF2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 138960    OMIM disorders: --

    Selected diseases for CSF2 (see all 227):    
    About MalaCards
    acquired agranulocytosis    ecthyma    anthracycline extravasations    leukemoid reaction
    5q- syndrome    felty's syndrome    capillary leak syndrome    anemia of prematurity
    idiopathic pulmonary alveolar proteinosis    chronic neutrophilic leukemia    candida glabrata    pulmonary alveolar proteinosis
    granulocytopenia    hypersplenism    meconium aspiration syndrome    richter's syndrome
    cytomegalovirus retinitis    carotid artery thrombosis    endophthalmitis    monocytic leukemia

    Selected diseases from the University of Copenhagen DISEASES database for CSF2 (see all 22):
    Neutropenia     Pulmonary alveolar proteinosis     Leukemia     Asthma
    Eosinophilia     Melanoma     Anemia     Thrombocytopenia
    Myeloma     Lymphoma     Bone marrow disease     Acquired immunodeficiency syndrome
    Arthritis     Breast cancer     Juvenile myelomonocytic leukemia     Lung cancer
    Dermatitis     Allergic rhinitis     Renal cell carcinoma     Carcinoma

    CSF2 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for CSF2 gene (see all 91)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 84 879 1966932 (2), 8353284 (2), 8406576 (2), 8926090 (2) (see all 99)
    neutropenia 78.9 140 16034921 (5), 8458047 (2), 9829843 (2), 14682115 (2) (see all 99)
    pulmonary alveolar proteinosis 77.2 36 16507860 (3), 16423274 (2), 16316563 (2), 8676086 (2) (see all 23)
    tumors 74.6 963 2205378 (3), 1966932 (2), 8353284 (2), 8632679 (2) (see all 99)
    juvenile myelomonocytic leukemia 70.9 10 9389708 (2), 12718797 (1), 16371368 (1), 18164384 (1) (see all 9)
    leukemia 69.3 113 8960144 (2), 2273055 (1), 7686393 (1), 7519043 (1) (see all 99)
    myeloid leukemia 67.2 23 1701353 (1), 1450413 (1), 8750618 (1), 8641372 (1) (see all 21)
    myelodysplastic syndromes 66 43 1698477 (2), 7679062 (2), 8286736 (2), 2405493 (1) (see all 37)
    eosinophilia 62.3 25 8485042 (2), 10802841 (2), 1646045 (1), 8627086 (1) (see all 22)
    anemia aplastic 60.5 30 1281785 (2), 8112428 (2), 1515094 (2), 7976114 (2) (see all 25)

    Genetic Association Database (GAD): CSF2
    Human Genome Epidemiology (HuGE) Navigator: CSF2 (54 documents)

    Export disorders for CSF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CSF2 gene, integrated from 10 sources (see all 2859):
    (articles sorted by number of sources associating them with CSF2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, sequence, and expression of a human granulocyte/macrophage colony-stimulating factor. (PubMed id 3898082)1, 2, 3 Cantrell M.A....Cosman D. (Proc. Natl. Acad. Sci. U.S.A. 1985)
    2. Association of genetic variations in the CSF2 and CSF3 genes with lung function in smoking-induced COPD. (PubMed id 18353856)1, 4, 9 He J.Q....Sandford A.J. (Eur. Respir. J. 2008)
    3. The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation. (PubMed id 18692472)1, 2, 9 Hansen G.... Parker M.W. (Cell 2008)
    4. Analysis of GM-CSF gene polymorphisms (3606T/C and 3928C/T) in Japanese patients with atopic dermatitis. (PubMed id 16487109)1, 4, 9 Saeki H....Tamaki K. (Clin. Exp. Dermatol. 2006)
    5. Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population. (PubMed id 22446963)1, 4 Okada Y....Yamamoto K. (Nat. Genet. 2012)
    6. Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer. (PubMed id 20811626)1, 4 Hildebrandt M.A....Wu X. (PLoS ONE 2010)
    7. Independent predictive roles of eotaxin Ala23Thr, paraoxonase 2 Ser311Cys and beta-adrenergic receptor Trp64Arg polymorphisms on cardiac disease in Type 2 Diabetes--an 8-year prospective cohort analysis of 1297 patients. (PubMed id 20536507)1, 4 Wang Y....Chan J.C. (Diabet. Med. 2010)
    8. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)
    9. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
    10. Single nucleotide polymorphisms in inflammation-related genes are associated with venous thromboembolism. (PubMed id 20603037)1, 4 Beckers M.M....Biesma D.H. (Eur. J. Intern. Med. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1437 HGNC: 2434 AceView: CSF2 Ensembl:ENSG00000164400 euGenes: HUgn1437
    ECgene: CSF2 Kegg: 1437 H-InvDB: CSF2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CSF2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CSF2 Genetics and Cytogenetics in Oncology and Haematology
    Leukinehttp://www.leukine.com/healthcare.aspx
    SeattleSNPshttp://pga.gs.washington.edu/data/csf2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CSF2 gene:
    Search GeneIP for patents involving CSF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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