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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CSF2 Gene

protein-coding GIFtS: 66
GCID: GC05P131409

colony stimulating factor 2 (granulocyte-macrophage)

Explore 239 diseases affiliated with
CSF2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Colony Stimulating Factor 2 (Granulocyte-Macrophage)¹ ²		Molgramostin³
GMCSF¹ ² ³ ⁵		Sargramostim³
GM-CSF¹ ³		Molgramostin³
CSF² ³		Sargramostim³
Granulocyte-Macrophage Colony-Stimulating Factor²		Colony-Stimulating Factor³

External Ids:	HGNC: 2434¹	Entrez Gene: 1437²	Ensembl: ENSG00000164400⁷	OMIM: 138960⁵	UniProtKB: P04141³

Export aliases for CSF2 gene to outside databases

Previous GC identifers: GC05P130931 GC05P131856 GC05P131440 GC05P131485 GC05P131437 GC05P126601

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CSF2:

The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of

granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has

been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with

interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those

encoding interleukins 4, 5, and 13. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CSF2_HUMAN, P04141

Function: Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various

lineages, including granulocytes, macrophages, eosinophils and erythrocytes

Gene Wiki entry for CSF2 (Granulocyte macrophage colony-stimulating factor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_034772.6

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CSF2 gene promoter:
AML1a STAT3
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CSF2 promoter sequence

Search SABiosciences Chromatin IP Primers for CSF2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CSF2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.1 Ensembl cytogenetic band: 5q31.1 HGNC cytogenetic band: 5q23-q31

CSF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CSF2 gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P131409: view genomic region (about GC identifiers)

Start:	131,409,483 bp from pter	End:	131,411,859 bp from pter
Size:	2,377 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CSF2_HUMAN, P04141 (See protein sequence)

Recommended Name: Granulocyte-macrophage colony-stimulating factor precursor

Size: 144 amino acids; 16295 Da

Subunit: Monomer. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two

beta, and two ligand subunits

Subcellular location: Secreted

3 PDB 3D structures from and Proteopedia for CSF2:

1CSG (3D)

2GMF (3D)

3CXE (3D)

Secondary accessions: Q14CE8 Q2VPI8 Q8NFI6

Explore the universe of human proteins at neXtProt for CSF2: NX_P04141

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P04141

CSF2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000749.2

ENSEMBL proteins:

ENSP00000296871

Reactome Protein details: P04141
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for CSF2 (GM-CSF)
	Enzo Life Sciences proteins for CSF2
	OriGene Purified Protein: CSF2 OriGene Protein Over-expression Lysate: CSF2 OriGene Custom Protein Services for CSF2
	GenScript Purified and Recombinant Proteins for CSF2
	Novus Biologicals CSF2 Proteins Novus Biologicals CSF2 Lysates
	Sino Biological Recombinant Protein for CSF2
	ProSpec Recombinant Protein for CSF2
	Uscn Proteins for CSF2

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IEA	--

CSF2 for ontologies About GeneDecksing

CSF2 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of CSF2
	R&D Systems Antibodies for CSF2 (GM-CSF)
	Browse OriGene Antibodies OriGene Custom Antibody Services for CSF2
	GenScript Superior Antibodies for CSF2
	Novus Biologicals CSF2 Antibodies
	Search for Antibodies for CSF2 at Abcam
	Uscn Antibodies for CSF2
	ThermoFisher Antibody for CSF2

Assay Products for CSF2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems Flow Cytometry Kits for CSF2 (GM-CSF) (see all)
	GenScript Custom Assay Services for CSF2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CSF2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CSF2 for domains About GeneDecksing

3 InterPro domains/families:

IPR012351 4_helix_cytokine_core

IPR000773 GM_colony-stim-fac

IPR009079 4_helix_cytokine-like_core

Graphical View of Domain Structure for InterPro Entry P04141

ProtoNet protein and cluster: P04141

1 Blocks protein family: IPB000773 Granulocyte-macrophage colony-stimulating factor

UniProtKB/Swiss-Prot: CSF2_HUMAN, P04141

Similarity: Belongs to the GM-CSF family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CSF2_HUMAN, P04141

Function: Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various

lineages, including granulocytes, macrophages, eosinophils and erythrocytes

Genatlas biochemistry entry for CSF2:

colony-stimulating factor 2,16.3kDa,(granulocyte-macrophage)

Summary:

CSF2 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells: Mature dendritic-like cells, Immature dendritic-like cells (see all 4).

miRNA Products:		OriGene 3'-UTR Clone: CSF2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CSF2
		1 QIAGEN miScript miRNA Assays for microRNA that regulate CSF2:
		hsa-miR-410
		SwitchGear 3'UTR luciferase reporter plasmid: CSF2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CSF2 (see all 4) OriGene shRNA RFP: CSF2 OriGene siRNA: CSF2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CSF2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CSF2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CSF2 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CSF2 (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CSF2 (NM_000758)
		Sino Biological Human cDNA Clone for CSF2
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CSF2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSF2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CSF2
		Search LifeMap BioReagents cell lines for CSF2

In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CSF2

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005125	cytokine activity	IEA	--
GO:0005129	granulocyte macrophage colony-stimulating factor receptor binding	IEA	--
GO:0005515	protein binding	IPI	18692472
GO:0008083	growth factor activity	IEA	--

CSF2 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for CSF2:

Increased cell death HMECs cel

Increased cell death in breast

Animal Models:
Mouse knock-outs for CSF2: Csf2^tm1Mlg Csf2^tm1Dran
15/19 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Csf2) (see all 19):

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial
embryogenesis	endocrine/exocrine gland	growth/size	hematopoietic system	homeostasis/metabolism
immune system	integument	mortality/aging	other	renal/urinary system

CSF2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/22 super-pathways (see all 22) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

PEDF Induced Signaling

8/9 pathways (see all 9)
PEDF Induced Signaling	1.00	RAR-Gamma-RXR-Alpha Degradation	0.54
MIF Mediated Glucocorticoid Regulation	0.73	STAT3 Pathway	0.47
MIF Regulation of Innate Immune Cells	0.71	Endothelin-1 Signaling Pathway	0.44
IL-6 Pathway	0.61	Cytokine-cytokine receptor interaction	0.26

Interleukin receptor SHC signaling

Interleukin receptor SHC signaling	1.00	Interleukin-3, 5 and GM-CSF signaling	0.57
Interleukin-2 signaling	0.67	The receptor is activated	0.29
Phosphorylated SHC1 recruits GRB2:GAB2	0.61	Signaling by Interleukins	0.25
SHC1 mediates cytokine-induced phosphorylation of GAB2	0.61

Rho Family GTPases

	Rho Family GTPases	1.00			Molecular Mechanisms of Cancer	0.51
	ERK Signaling	0.61

Immune response CD16 signaling in NK cells

Immune response CD16 signaling in NK cells

1.00

Immune response_CD16 signaling in NK cells

0.99

PAK Pathway

PAK Pathway

1.00

Antioxidant Action of Vitamin-C

0.56

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for CSF2

Immune response CD16 signaling in NK cells

1 R&D Systems Pathway for CSF2

IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types

5/15 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CSF2 (see all 15)

	MIF Regulation of Innate Immune Cells
	STAT3 Pathway
	Endothelin-1 Signaling Pathway
	Molecular Mechanisms of Cancer
	Antioxidant Action of Vitamin-C

3 GeneGo (Thomson Reuters) Pathways for CSF2

	Immune response CD16 signaling in NK cells
	Cytokine production by Th17 cells in CF (Mouse model)
	Cytokine production by Th17 cells in CF

5/6 BioSystems Pathways for CSF2 (see all 6)

	Cytokines and Inflammatory Response
	Calcium signaling in the CD4+ TCR pathway
	Syndecan-2-mediated signaling events
	Glucocorticoid receptor regulatory network
	Calcineurin-regulated NFAT-dependent transcription in lymphocytes

5/9 Reactome Pathways for CSF2 (see all 9)

	SHC1 mediates cytokine-induced phosphorylation of GAB2
	Interleukin receptor SHC signaling
	Interleukin-2 signaling
	Phosphorylated SHC1 recruits GRB2:GAB2
	Cytokine Signaling in Immune system

5/8 Kegg Pathways (Kegg details for CSF2) (see all 8):

	Cytokine-cytokine receptor interaction
	Jak-STAT signaling pathway
	Hematopoietic cell lineage
	Natural killer cell mediated cytotoxicity
	T cell receptor signaling pathway

CSF2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CSF2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/51 Interacting proteins for CSF2 (P04141^{1, 3} ENSP00000296871⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 51)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CSF2RB	P32927¹^,³, ENSP00000384053⁴	EBI-1809826,EBI-1809771 I2D: score=3 STRING: ENSP00000384053
CSF2RA	P15509³, ENSP00000370935⁴	I2D: score=3 STRING: ENSP00000370935
IL3RA	P26951³, ENSP00000327890⁴	I2D: score=2 STRING: ENSP00000327890
PRG2	P13727³, ENSP00000312134⁴	I2D: score=2 STRING: ENSP00000312134
KITLG	P21583³, ENSP00000228280⁴	I2D: score=1 STRING: ENSP00000228280

About this table

Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001892	embryonic placenta development	IEA	--
GO:0006955	immune response	IEA	--
GO:0008284	positive regulation of cell proliferation	IEA	--
GO:0010468	regulation of gene expression	--	--
GO:0010628	positive regulation of gene expression	IDA	10666185

CSF2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CSF2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CSF2
UniProtKB/Swiss-Prot: CSF2_HUMAN, P04141

Pharmaceutical: Available under the names Leukine (Immunex) and Leucomax (Novartis). Used in myeloid reconstitution

following bone marrow transplant, bone marrow transplant engraftment failure or delay, mobilization and following

transplantation of autologous peripheral blood progenitor cells, and following induction chemotherapy in older adults

with acute myelogenous leukemia

10/145 Novoseek chemical compound relationships for CSF2 gene (see all 145) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
gm-csf	94.5	394	1423182 (11), 1854591 (10), 18782657 (8), 9832332 (8) (see all 99)
pixy321	79	21	1383918 (3), 8405227 (2), 9816121 (2), 9490056 (2) (see all 14)
molgramostim	77.1	8	7781752 (1), 8158688 (1), 9124202 (1), 7579383 (1) (see all 8)
fmlp	71	53	15107457 (2), 9427721 (2), 10419502 (2), 1382715 (1) (see all 42)
rantes	66.6	62	9003213 (2), 8757214 (2), 8998072 (2), 10792507 (1) (see all 56)
n-formylmethionyl-leucylphenylalanine	65.4	19	2123794 (1), 8144533 (1), 7679062 (1), 1281785 (1) (see all 17)
methylcellulose	62.8	11	1903073 (1), 1518302 (1), 9238762 (1), 11369665 (1) (see all 11)
filgrastim	62.6	30	7683736 (2), 16258470 (2), 8074347 (1), 9142195 (1) (see all 23)
provenge	60.1	4	11099318 (1), 17696825 (1), 17362049 (1)
cytarabine	59.9	46	1737098 (2), 14984497 (2), 1553573 (2), 1593908 (2) (see all 33)

Search CenterWatch for drugs/clinical trials and news about CSF2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CSF2 gene:

NM_000758.3

Unigene Cluster for CSF2:

Colony stimulating factor 2 (granulocyte-macrophage)

Hs.1349 [show with all ESTs]

Unigene Representative Sequence: BE873976

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000296871(uc003kwf.3)

miRNA Products:		OriGene 3'-UTR Clone: CSF2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CSF2
		1 QIAGEN miScript miRNA Assays for microRNA that regulate CSF2:
		hsa-miR-410
		SwitchGear 3'UTR luciferase reporter plasmid: CSF2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CSF2 (see all 4) OriGene shRNA RFP: CSF2 OriGene siRNA: CSF2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CSF2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CSF2 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CSF2 (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CSF2 (NM_000758)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CSF2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSF2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CSF2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CSF2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CSF2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CSF2

Additional cDNA sequence:

AF510855.1 AY720441.1 BC108724.1 BC113924.1 BC113999.1 M10663.1 M11220.1 M11734.1

1 DOTS entry:

DT.110709

20 AceView cDNA sequences:

NM_000758 CD369973 CD367244 AY720441 AI655452 BV202503 M11220 M10663

M11734 CD368851 BG236310 T29160 BE873976 CA307828 BU633411 AF510855

AA361936 AI677936 CA309134 AW951121

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CSF2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGGGAGTGG

About this image

CSF2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Heart

Myocardium

Mature Cardiac Fibroblasts

Epicardium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CSF2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CSF2

SOURCE GeneReport for Unigene cluster: Hs.1349

SABiosciences Expression via Pathway-Focused PCR Arrays including CSF2 (see all 25):

Interferons & Receptors in human mouse rat

Wound Healing in human mouse rat

T-cell & B-cell Activation in human mouse rat

Th17 Response in human mouse rat

Mesenchymal Stem Cell in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CSF2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CSF2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CSF2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CSF2

In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CSF2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for CSF2 gene from 1/5 species (see all 5) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Csf2^{1 , 5}	colony stimulating factor 2 (granulocyte-macrophage)^{1, 5}	71.16(n)¹ 56.03(a)¹		11 (32.13 cM)⁵ 12981¹ NM_009969.4¹ NP_034099.2¹ 54247271⁵

ENSEMBL Gene Tree for CSF2 (if available)
TreeFam Gene Tree for CSF2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

UniProtKB/Swiss-Prot: CSF2_HUMAN, P04141

Polymorphism: Variant Ile-117 may be a risk factor for atopic asthma

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs79970273^1,2	F,	--	131407490(+)	`CTGGAC/TTTCCC`	1	--	us2k¹		1		WA	118
rs4705916^1,2	C,F,A,H,	--	131407493(+)	`GACTTC/ACCCCT`	1	--	us2k¹ tfbs³		9		NA NS EA WA	674
rs143858270^1,2		--	131407502(+)	`CTGCCA/GAGTCA`	1	--	us2k¹		0	--	--	--	--
rs2069614^1,2	C,F,O,A,H,	--	131407601(+)	`CCGTTT/CACCTC`	1	--	us2k¹		21		NS EA NA WA CSA	2296
rs2069635^1,2	C,H,	--	131407674(+)	`CTCATT/CTCTAG`	1	--	us2k¹		7		NS EA	688
rs112840012^1,2		--	131407844(+)	`CCCCCG/AAGAGC`	1	--	us2k¹		2		CSA WA	120
rs115193992^1,2	F,	--	131407868(+)	`CTGAGC/TCAAGG`	1	--	us2k¹		1		WA	118
rs147236536^1,2		--	131408049(+)	`GTACAC/GGGAAA`	1	--	us2k¹		0	--	--	--	--
rs2069615^1,2	C,F,	--	131408065(+)	`CAGGGC/TTGCAG`	1	--	us2k¹		4		NS EA WA	388
rs2069616^1,2	C,F,A,H,	--	131408077(+)	`CTCAGA/GCCACA`	1	--	us2k¹		19		NS NA EA WA CSA	1066

HapMap Linkage Disequilibrium report for CSF2 (131409483 - 131411859 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CSF2
1 CNV: 69200
Human Gene Mutation Database (HGMD): CSF2

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CSF2

DNA2.0 Custom Variant and Variant Library Synthesis for CSF2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CSF2 for disorders           About GeneDecksing

OMIM gene information: 138960    OMIM disorders: --

20/239 diseases for CSF2 (see all 239):    About MalaCards

leukemia capillary leak syndrome pulmonary alveolar proteinosis spinal cord injury

epidermolysis bullosa acquisita relapsing-remitting multiple sclerosis leukemoid reaction hyper-ige syndrome

dyskeratosis congenita middle ear cholesteatoma langerhans-cell histiocytosis hypersensitivity reaction type ii disease

candida glabrata epidermolysis bullosa juvenile myelomonocytic leukemia human immunodeficiency virus infectious disease

meconium aspiration syndrome otitis media large granular lymphocyte leukemia myelomonocytic leukemia

20/25 diseases from the University of Copenhagen DISEASES database for CSF2 (see all 25):

Neutropenia Pulmonary alveolar proteinosis Leukemia Asthma

Eosinophilia Melanoma Anemia Thrombocytopenia

Myeloma Lymphoma Bone marrow disease Juvenile myelomonocytic leukemia

Arthritis Breast cancer Lung cancer Dermatitis

Pneumonia Allergic rhinitis Human immunodeficiency virus infectious disease Renal cell carcinoma

10/91 Novoseek disease relationships for CSF2 gene (see all 91) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis	84	879	1966932 (2), 8353284 (2), 8406576 (2), 8926090 (2) (see all 99)
neutropenia	78.9	140	16034921 (5), 8458047 (2), 9829843 (2), 14682115 (2) (see all 99)
pulmonary alveolar proteinosis	77.2	36	16507860 (3), 16423274 (2), 16316563 (2), 8676086 (2) (see all 23)
tumors	74.6	963	2205378 (3), 1966932 (2), 8353284 (2), 8632679 (2) (see all 99)
juvenile myelomonocytic leukemia	70.9	10	9389708 (2), 12718797 (1), 16371368 (1), 18164384 (1) (see all 9)
leukemia	69.3	113	8960144 (2), 2273055 (1), 7686393 (1), 7519043 (1) (see all 99)
myeloid leukemia	67.2	23	1701353 (1), 1450413 (1), 8750618 (1), 8641372 (1) (see all 21)
myelodysplastic syndromes	66	43	1698477 (2), 7679062 (2), 8286736 (2), 2405493 (1) (see all 37)
eosinophilia	62.3	25	8485042 (2), 10802841 (2), 1646045 (1), 8627086 (1) (see all 22)
anemia aplastic	60.5	30	1281785 (2), 8112428 (2), 1515094 (2), 7976114 (2) (see all 25)

Genetic Association Database (GAD): CSF2
Human Genome Epidemiology (HuGE) Navigator: CSF2 (54 documents)

Export disorders for CSF2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CSF2 gene, integrated from 9 sources (see all 2844):
(articles sorted by number of sources associating them with CSF2)

Utopia: connect your pdf to the dynamic
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Cloning, sequence, and expression of a human granulocyte/macrophage colony-stimulating factor. (PubMed id 3898082)^{1, 2, 3} Cantrell M.A....Cosman D. (1985)
The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation. (PubMed id 18692472)^{1, 2, 9} Hansen G....Parker M.W. (2008)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)^{1, 2} Schmutz J.... Rubin E.M. (2004)
Association between novel GM-CSF gene polymorphisms and the frequency and severity of atopic dermatitis. (PubMed id 13679820)^{1, 4} Rafatpanah H....Arkwright P.D. (2003)
Polymorphisms of the GM-CSF genes and the development of atopic diseases in at-risk children. (PubMed id 12629028)^{1, 4} He J.Q....Sandford A.J. (2003)
Three-dimensional structure of recombinant human granulocyte- macrophage colony-stimulating factor. (PubMed id 1569568)^{1, 2} Walter M.R....Bugg C.E. (1992)
Role of carbohydrate modification in the production and secretion of human granulocyte macrophage colony-stimulating factor in genetically engineered and normal mesenchymal cells. (PubMed id 1737041)^{1, 2} Kaushansky K.... Brown C.B. (1992)
Novel fold and putative receptor binding site of granulocyte- macrophage colony-stimulating factor. (PubMed id 1837174)^{1, 2} Diederichs K.... Karplus P.A. (1991)
Genomic cloning, characterization, and multilineage growth-promoting activity of human granulocyte-macrophage colony-stimulating factor. (PubMed id 3486413)^{1, 2} Kaushansky K....Adamson J.W. (1986)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 1437	HGNC: 2434	AceView: CSF2	Ensembl:ENSG00000164400	euGenes: HUgn1437
ECgene: CSF2	Kegg: 1437	H-InvDB: CSF2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CSF2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CSF2	Genetics and Cytogenetics in Oncology and Haematology
Leukine	http://www.leukine.com/healthcare.aspx
SeattleSNPs	http://pga.gs.washington.edu/data/csf2/

Intellectual Property for CSF2 gene
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Patent Information for CSF2 gene:
Search GeneIP for patents involving CSF2

GeneCards and IP:
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CSF2 Gene

colony stimulating factor 2 (granulocyte-macrophage)

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stable disease
Hematologic Effects
Leukemoid Reaction
sepsis
Dyskeratosis Congenita
Leukemia Myelomonocytic Chronic
Erythroleukemia
Dermatitis Atopic
Megakaryoblastic Leukemia Acute
Allergic Reaction
Aplasia
Lymphoma Follicular
Capillary Leak Syndrome
NSCLC
Asthma
Allergic rhinitis
Cancer
Thrombocytopenia
Lymphoma
Ovarian Cancer
Granulomatous Disease Chronic
Myeloproliferative Disorders
Nasal Polyps
Bronchoalveolar Lavage Fluid
Sarcoidosis Pulmonary
NEUTROPENIA, SEVERE CONGENITAL
HEMATOLOGIC DISORDERS
HNSCC
Inflammation
Leukemia Eosinophilic
Monocytic leukemia
immunodeficiency
Neutropenia
Anemia
MYELOMA
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Tumors
DEPRESSION BONE MARROW
Lymphoblastic Leukemia Acute
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breast cancer metastatic
progressive disease
JUVENILE MYELOMONOCYTIC LEUKEMIA
Thrombocytosis
Myeloid Leukemia
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promyelocytic leukemia
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Tetanus
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metastatic melanoma
Carcinoma Renal Cell
SEPSIS NEONATAL
Hematologic Malignancies
Cancer Lung
metastatic renal cell carcinoma
NEUTROPENIA CYCLIC
INFECTION FUNGAL
Pleural Effusion Malignant
cytopenia
Fowlpox
Diphtheria
HIV Infections
Eosinophilia
mucositis
solid tumor
Lung diseases
Kostmanns syndrome
Anemia Aplastic
Graft-Versus-Host Disease
leukemogenesis
Lymphoma Non-Hodgkins
Stomatitis
Feltys Syndrome
Myelodysplastic Syndromes
LEUKAEMIA LYMPHOCYTIC
Choriocarcinoma

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CSF2 Gene

colony stimulating factor 2 (granulocyte-macrophage)

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