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CSF1R Gene

protein-coding GIFtS: 65

GC05M149413

colony stimulating factor 1 receptor
(Previous name: McDonough feline sarcoma viral (v-fms) oncogene homolog )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: FMS)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
C-FMS ^¹, ²
CD115 ^¹, ²
CSF-1-R ^³
CSFR ^¹, ²
EC 2.7.10.1 ^³
FIM2 ^²
FMS ^², ³, ⁵
c-fms ^³

Descriptions
CD115 antigen ^², ³
Fms proto-oncogene ^², ³
McDonough feline sarcoma viral (v-fms) oncogene homolog ^¹, ²
colony stimulating factor 1 receptor ^²
macrophage colony stimulating factor I receptor ^²
soluble CSF1R variant 1 ^²

External Ids
HGNC: 2433¹
Entrez Gene: 1436²
UniProtKB: P07333³
Ensembl: ENSG00000182578⁷

Search outside databases for aliases for CSF1R gene

Previous GC identifers: GC05M149503 GC05M150020 GC05M149416 GC05M149461

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for CSF1R:

The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which

controls the production, differentiation, and function of macrophages. This receptor mediates most

if not all of the biological effects of this cytokine. Ligand binding activates the receptor

kinase through a process of oligomerization and transphosphorylation. The encoded protein is a

tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of

tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to

myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal

protein L7 processed pseudogene oriented in the opposite direction. [provided by RefSeq]

UniProtKB/Swiss-Prot: CSF1R_HUMAN, P07333

Function: Protein tyrosine-kinase transmembrane receptor for CSF1 and IL34

Gene Wiki entry for CSF1R (Colony_stimulating_factor_1_receptor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CSF1R gene

Entrez Gene cytogenetic band: 5q33-q35 Ensembl cytogenetic band: 5q33.1 HGNC cytogenetic band: 5q32

CSF1R Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M149413: (about GC identifiers)

Start:	149,413,051 bp from pter
End:	149,473,128 bp from pter
Size:	60,078 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000005.8 NT_029289.10

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: CSF1R_HUMAN, P07333 (See protein sequence)

Recommended Name: Macrophage colony-stimulating factor 1 receptor precursor

Size: 972 amino acids; 107984 Da

Subunit: Interacts with INPPL1/SHIP2 and THOC5 (By similarity)

Subcellular location: Membrane; Single-pass type I membrane protein

PDB structures from and Proteopedia :

2I0V (3D)

2I0Y (3D)

2I1M (3D)

2OGV (3D)

3BEA (3D)

3DPK (3D)

Secondary accessions: Q6LDW5 Q6LDY4

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_005202.2

ENSEMBL proteins:

ENSP00000286301 ENSP00000377844

Human Recombinant Proteins

	Invitrogen human recombinant proteins for CSF1R
	Millipore Purified and/or Recombinant CSF1R Protein
	Sigma-Aldrich Proteins and CompoZr ZFN for CSF1R
	R&D Systems Recombinant & Natural Proteins for CSF1R (M-CSF R)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (MCSF Receptor)
	Human Recombinant Proteins from Abnova (CSF1R)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	2421165
GO:0005887	integral to plasma membrane	TAS	2421165
GO:0043235	receptor complex	ISS	19017797

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Antibodies for CSF1R:

	Invitrogen Antibodies for CSF1R
	Millipore Mono- and Polyclonal Antibodies for the study of CSF1R
	Sigma-Aldrich Antibodies for CSF1R
	R&D Systems Antibodies for CSF1R (M-CSF R)
	Cell Signaling Technology (CST) Antibodies for CSF1R
	Antibodies from Abcam (MCSF Receptor), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (CSF1R)
	Novus Biologicals Antibodies for CSF1R

Assays for CSF1R:

	Invitrogen Assays for CSF1R
	Millipore Kits and Assays for the Analysis of CSF1R
	R&D Systems ELISAs for CSF1R (M-CSF R) (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P07333

ProtoNet protein and cluster: P07333

4 Blocks protein families:

IPB001824 Receptor tyrosine kinase

IPB003598 Immunoglobulin C-2 type

IPB008266 Tyrosine protein kinase

IPB013106 Immunoglobulin V-set

UniProtKB/Swiss-Prot: CSF1R_HUMAN, P07333

Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF

receptor subfamily

Similarity: Contains 5 Ig-like C2-type (immunoglobulin-like) domains

Similarity: Contains 1 protein kinase domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CSF1R)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CSF1R)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005211

Applied Biosystems Silencer® siRNAs for CSF1R

Sigma-Aldrich siRNA and siRNA Panels for CSF1R

Sigma-Aldrich shRNA Panels and shRNA for CSF1R

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_005211
Myc/DDK tagged cDNA clone in CMV expression vector: NM_005211
untagged cDNA clones in CMV expression vector (see all 2): NM_005211

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_005211

UniProtKB/Swiss-Prot: CSF1R_HUMAN, P07333

Function: Protein tyrosine-kinase transmembrane receptor for CSF1 and IL34

Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

Enzyme Number (IUBMB): EC 2.7.10.1

Genatlas biochemistry entry for CSF1R:

colony-stimulating factor 1 (macrophage),receptor

13 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Csf1r):

behavior/neurological	craniofacial	endocrine/exocrine gland	growth/size	hearing/vestibular/ear
hematopoietic system	homeostasis/metabolism	immune system	lethality-postnatal	life span-post-weaning/aging
limbs/digits/tail	reproductive system	skeleton

5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0004872	receptor activity	IEA	--
GO:0005011	macrophage colony stimulating factor receptor activity	TAS	8981357
GO:0005524	ATP binding	IEA	--
GO:0016740	transferase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for CSF1R (Your Favorite Gene powered by Ingenuity)

Acute Myeloid Leukemia Signaling
Macropinocytosis

GeneDecks CSF1R for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for CSF1R

5/54 Interacting proteins for CSF1R (ENSP00000286301³) via UniProtKB, MINT, and/or STRING (see all 54 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CSF1	ENSP00000349854³	STRING (score=.999)
CBL	ENSP00000264033³	STRING (score=.994)
GRB2	ENSP00000339007³	STRING (score=.992)
CSF2	ENSP00000296871³	STRING (score=.99)
THOC5	ENSP00000350787³	STRING (score=.979)

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5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006468	protein amino acid phosphorylation	IEA	--
GO:0007165	signal transduction	TAS	8981357
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IEA	--
GO:0007275	multicellular organismal development	TAS	8981357
GO:0008283	cell proliferation	TAS	8981357

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for CSF1R
10/24 Novoseek chemical compound relationships for CSF1R gene (see all 24 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	71.89	166	14969583 (4), 8981370 (4), 1833648 (3), 16648572 (3) (see all 89)
nitroblue tetrazolium	54.98	6	8913320 (1), 11911463 (1), 2144331 (1), 8462021 (1) (see all 5)
12-o-tetradecanoylphorbol 13-acetate	40.55	29	2144778 (6), 8359233 (6), 9301678 (2), 2140592 (2) (see all 7)
phosphatidylinositol	39.14	21	2164469 (4), 1372092 (2), 1708091 (2), 1833648 (1) (see all 10)
bryostatin 1	37.79	3	9279365 (2), 11777344 (1)
phorbol	37.52	3	15286807 (1), 2144778 (1), 1848705 (1)
1,25 dihydroxy vitamin d3	32.87	5	9158000 (2), 8398907 (1), 8227169 (1)
phosphotyrosine	29.39	5	15236912 (1), 1708091 (1), 9366562 (1)
phenylalanine	26.39	11	9372970 (1), 8007983 (1), 2157180 (1), 1950818 (1) (see all 7)
hpaii	23.46	2	1593906 (1), 1831986 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CSF1R)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CSF1R)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005211

Sigma-Aldrich siRNA and siRNA Panels for CSF1R

Sigma-Aldrich shRNA Panels and shRNA for CSF1R

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_005211

REFSEQ mRNAs for CSF1R gene:

NM_005211.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_005211

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005211
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_005211
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_005211

Additional cDNA sequence:

AB208819.1 AK294467.1 AK304491.1 BC047521.1 BC129939.1 BX648599.1 CR613133.1 EU826593.1

M14193.1 X03663.1

11 DOTS entries:

DT.97770481 DT.100814450 DT.452452 DT.101965758 DT.100813294 DT.95333580 DT.120845509 DT.97833313

DT.120845651 DT.91936822 DT.95214896

24/463 AceView cDNA sequences (see all 463 ):

CK300063 BQ709453 AA368051 BP360429 BM704575 BM702001 BU069362 CR593034

BF377002 CD518518 CD369309 BX479433 CR613133 R70545 CD369943 BM689263

CN483678 BU069568 CR612121 AA912447 AA284843 M14193 AA359391 AI590783

highest scoring ESTs for CSF1R:

X03663 AL548995 AA193563 AA233785 AA233793 AA236817 AA252920 AA253063 AA255450 AA256557

Unigene Cluster for CSF1R:

Colony stimulating factor 1 receptor

Hs.586219 [show with all ESTs]

Unigene Representative Sequence: NM_005211

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000286301 ENST00000394307

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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CSF1R expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CSF1R

¹ / ² / ³

3 probe-sets matching CSF1R gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
160022_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	X03663	1.00	1.00	1.00	1
203104_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_005211	0.60	1.00	0.82	1
203104_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks CSF1R for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.586219
Expression variation in blood from EXPOLDB for CSF1R
UniProtKB/Swiss-Prot: CSF1R_HUMAN, P07333
Tissue specificity: Expressed in bone marrow and in differentiated blood mononuclear cells

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CSF1R gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CSF1R¹	--	colony stimulating factor 1 receptor	86.09(n) 84.78(a)	489188 XM_546306.2 XP_546306.2
cow (Bos taurus)	CSF1R¹	--	colony stimulating factor 1 receptor	81.1(n) 75.1(a)	509418 NM_001075403.1 NP_001068871.1
rat (Rattus norvegicus)	Csf1r¹	--	colony stimulating factor 1 receptor	79.78(n) 78.17(a)	307403 NM_001029901.1 NP_001025072.1
mouse (Mus musculus)	Csf1r^{1, 5}	18 (30.00 cM)⁵	colony stimulating factor 1 receptor^{1, 5}	79.63(n)¹ 75.59(a)¹	12978¹ NM_001037859.2¹ NP_001032948.2¹ AI323359⁵ AK004947⁵ (see all 36)
chicken (Gallus gallus)	CSF1R¹	--	colony stimulating factor 1 receptor, formerly McDonough more	59.24(n) 53.57(a)	396406 XM_414597.2 XP_414597.2

About this table Species with no ortholog for CSF1R

ENSEMBL Gene Tree for CSF1R

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for CSF1R gene

KIT² FLT3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/425 NCBI SNPs in CSF1R are shown (see all 425 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 208)

AB	SNP ID	Valid	Chr 5 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs3829986^1,2	C,F,H	149437086(-)	`CCTGCG/ATGGCC`	1	M/V	mis¹ ese³		8	EU EA WA	832
	rs10079250^1,2	C,F,H	149430325(+)	`AGGTGT/CGCCTG`	1	R/H	mis¹ ese³		5	EU EA WA NA	464
--	rs17855673^1,2	H	149437181(+)	`GTTGAG/TGGATT`	1	P/H	mis¹ ese³		4	EU EA WA	420
	rs216123^1,2	A,C,F,H,O	149440746(+)	`AGCTCA/GGGGAC`	1	P/P	syn¹		10	EA MN NA EU WA	740
	rs2228422^1,2	C,F,H	149437871(-)	`AACACC/TAAGGT`	1	T/T	syn¹		10	MN EA NA EU WA	724
	rs17652007^1,2	C,F,H	149440536(+)	`TAGAGA/GTGGAT`	1	H/H	syn¹ ese³		9	NA EA EU WA	656
	rs3733670^1,2	H	149419473(+)	`TTCTTC/TTCGAG`	1	E/E	syn¹ ese³		4	EU EA WA	418
	rs216143^1,2	A,C,F,H,O	149424340(+)	`AAGGCA/GAGGAG`	1	--	int¹ trp³		18	MN EU EA WA NA	3130
	rs216137^1,2	A,C,F,H,O	149416738(+)	`AGACCA/GCGTGC`	1	--	int¹		9	MN EA NA EU WA	816
	rs114792^1,2	A,C,F,H,O	149441146(-)	`AATACG/ATCCAC`	1	--	int¹		15	NA EA EU WA	1116

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HapMap Linkage Disequilibrium images for CSF1R (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 164770

10/61 Novoseek disease relationships for CSF1R gene (see all 61 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
5q- syndrome	69.55	3	9624537 (1), 1613006 (1)
malignant histiocytosis	63.25	1	8352523 (1)
myeloid leukemia	61.47	5	18337452 (1), 8462021 (1), 2214871 (1), 1942539 (1) (see all 5)
leukemia	54.55	34	8493986 (3), 18337452 (2), 7845011 (2), 7950916 (2) (see all 16)
myelodysplastic syndromes	53.85	6	7858491 (2), 8127154 (1), 7694008 (1), 1942539 (1)
leukemogenesis	51.73	6	1518154 (1), 17960171 (1), 14654075 (1), 2154646 (1) (see all 5)
leukemia myelomonocytic acute	46.31	2	1831986 (1), 2154646 (1)
preleukemia	44.06	1	1420444 (1)
breast carcinoma	40.76	22	7845678 (3), 9191055 (2), 7846733 (2), 10554038 (2) (see all 13)
tumors	40.38	70	10419732 (4), 1825026 (3), 11775455 (2), 17332318 (2) (see all 45)

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Human Gene Mutation Database: CSF1R
Genetic Association Database: CSF1R
Human Genome Epidemiology Navigator: CSF1R (6 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/445 PubMed articles for CSF1R gene (see all 445 ):

Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)^{3, 4} Liu T.... Smith R.D. (2005)
Association of the T allele of an intronic single nucleotide polymorphism in the colony stimulating factor 1 receptor with Crohn's disease: a case-control study. (PubMed id 15144560)^{3, 6} Zapata-Velandia A....Mannick E.E. (2004)
[Detection of two polymorphic sites in the human c-fms gene: allele frequency and genotype in some populations of Russia] (PubMed id 11852791)^{3, 6} Romashchenko A.G....Voevoda M.I. (2002)
Sequence analysis of two genomic regions containing the KIT and the FMS receptor tyrosine kinase genes. (PubMed id 9027509)^{3, 4} Andre C.... Galibert F. (1997)
Localization of the 5' end of the MCF2 oncogene to human chromosome 15q15----q23. (PubMed id 1611909)^{2, 3} Galland F....Birnbaum D. (1992)
Differential transcription of exon 1 of the human c-fms gene in placental trophoblasts and monocytes. (PubMed id 2524648)^{3, 4} Visvader J. and Verma I.M. (1989)
Nucleotide sequence and structural organization of the human FMS proto-oncogene. (PubMed id 2524025)^{3, 4} Hampe A.... Galibert F. (1989)
Structural alteration of viral homologue of receptor proto-oncogene fms at carboxyl terminus. (PubMed id 2421165)^{3, 4} Coussens L.... Ullrich A. (1986)
The amino-terminal domain of the v-fms oncogene product includes a functional signal peptide that directs synthesis of a transforming glycoprotein in the absence of feline leukemia virus gag sequences. (PubMed id 3525854)^{3, 4} Wheeler E.F.... Sherr C.J. (1986)
'Replacement' of COOH-terminal truncation of v-fms with c-fms sequences markedly reduces transformation potential. (PubMed id 3532121)^{3, 4} Browning P.J.... Nienhuis A.W. (1986)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 1436	HGNC: 2433	AceView: PDGFRBandCSF1R	Ensembl:ENSG00000182578	euGenes: HUgn1436
ECgene: CSF1R	H-InvDB: CSF1R

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for CSF1R	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for CSF1R
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for CSF1R:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CSF1R-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CSF1R		Antibodies for CSF1R
	Explore super-pooled esiRNAs		Proteins for CSF1R
	Lentivirus-delivered shRNAs for CSF1R		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (CSF1R)
	Antibodies (CSF1R)
	Chimera RNAi (CSF1R)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for CSF1R

	Recombinant Proteins (MCSF Receptor)
	Antibodies (MCSF Receptor)

Search OriGene for CSF1R

Search Tocris compounds for CSF1R

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for CSF1R

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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CSF1R Gene at Home site.
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CSF1R Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for CSF1R

Summaries
for CSF1R

Genomic Location
for CSF1R

Proteins
for CSF1R

Protein Domains/
Families
for CSF1R

Gene Function
for CSF1R

Pathways & Interactions
for CSF1R

Drugs & Compounds
for CSF1R

Transcripts
for CSF1R

Expression
for CSF1R

Orthologs
for CSF1R

Paralogs
for CSF1R

SNPs/Variants
for CSF1R

Disorders & Mutations
for CSF1R

Medical News
for CSF1R

Publications
for CSF1R

Search for CSF1R

Genome Databases showing CSF1R

Other Databases showing CSF1R

Specialized Databases showing CSF1R

Licensable Technologies
for CSF1R

Services
for CSF1R

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CSF1R Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor CSF1R

Summariesfor CSF1R

Genomic Locationfor CSF1R

Proteinsfor CSF1R

Protein Domains/Familiesfor CSF1R

Gene Functionfor CSF1R

Pathways & Interactionsfor CSF1R

Drugs & Compoundsfor CSF1R

Transcriptsfor CSF1R

Expression for CSF1R

Orthologsfor CSF1R

Paralogsfor CSF1R

SNPs/Variantsfor CSF1R

Disorders & Mutationsfor CSF1R

Medical Newsfor CSF1R

Publicationsfor CSF1R

Search for CSF1R

Genome Databases showing CSF1R

Other Databases showing CSF1R

Specialized Databases showing CSF1R

Licensable Technologiesfor CSF1R

Servicesfor CSF1R

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CSF1R

Summaries
for CSF1R

Genomic Location
for CSF1R

Proteins
for CSF1R

Protein Domains/
Families
for CSF1R

Gene Function
for CSF1R

Pathways & Interactions
for CSF1R

Drugs & Compounds
for CSF1R

Transcripts
for CSF1R

Expression
for CSF1R

Orthologs
for CSF1R

Paralogs
for CSF1R

SNPs/Variants
for CSF1R

Disorders & Mutations
for CSF1R

Medical News
for CSF1R

Publications
for CSF1R

Licensable Technologies
for CSF1R

Services
for CSF1R