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Aliases for CSF1R Gene

Aliases for CSF1R Gene

  • Colony Stimulating Factor 1 Receptor 2 3 5
  • McDonough Feline Sarcoma Viral (V-Fms) Oncogene Homolog 2 3
  • Proto-Oncogene C-Fms 3 4
  • CSF-1 Receptor 3 4
  • CD115 Antigen 3 4
  • EC 2.7.10.1 4 63
  • M-CSF-R 3 4
  • CSF-1R 3 4
  • FMS 3 4
  • Macrophage Colony Stimulating Factor I Receptor 3
  • FMS Proto-Oncogene 3
  • EC 2.7.10 63
  • CSF-1-R 4
  • C-FMS 3
  • CD115 3
  • CSFR 3
  • FIM2 3
  • HDLS 3

External Ids for CSF1R Gene

Previous HGNC Symbols for CSF1R Gene

  • FMS

Previous GeneCards Identifiers for CSF1R Gene

  • GC05M149503
  • GC05M150020
  • GC05M149416
  • GC05M149461
  • GC05M149413
  • GC05M144580

Summaries for CSF1R Gene

Entrez Gene Summary for CSF1R Gene

  • The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

GeneCards Summary for CSF1R Gene

CSF1R (Colony Stimulating Factor 1 Receptor) is a Protein Coding gene. Diseases associated with CSF1R include leukoencephalopathy, diffuse hereditary, with spheroids and csf1r-related hereditary diffuse leukoencephalopathy with spheroids. Among its related pathways are Immune System and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is FGFR1.

UniProtKB/Swiss-Prot for CSF1R Gene

  • Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion. Activates several signaling pathways in response to ligand binding. Phosphorylates PIK3R1, PLCG2, GRB2, SLA2 and CBL. Activation of PLCG2 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, that then lead to the activation of protein kinase C family members, especially PRKCD. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to activation of the AKT1 signaling pathway. Activated CSF1R also mediates activation of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1, and of the SRC family kinases SRC, FYN and YES1. Activated CSF1R transmits signals both via proteins that directly interact with phosphorylated tyrosine residues in its intracellular domain, or via adapter proteins, such as GRB2. Promotes activation of STAT family members STAT3, STAT5A and/or STAT5B. Promotes tyrosine phosphorylation of SHC1 and INPP5D/SHIP-1. Receptor signaling is down-regulated by protein phosphatases, such as INPP5D/SHIP-1, that dephosphorylate the receptor and its downstream effectors, and by rapid internalization of the activated receptor.

Gene Wiki entry for CSF1R Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSF1R Gene

Genomics for CSF1R Gene

Regulatory Elements for CSF1R Gene

Transcription factor binding sites by QIAGEN in the CSF1R gene promoter:

Genomic Location for CSF1R Gene

Chromosome:
5
Start:
150,053,291 bp from pter
End:
150,113,372 bp from pter
Size:
60,082 bases
Orientation:
Minus strand

Genomic View for CSF1R Gene

Genes around CSF1R on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CSF1R Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CSF1R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSF1R Gene

Proteins for CSF1R Gene

  • Protein details for CSF1R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07333-CSF1R_HUMAN
    Recommended name:
    Macrophage colony-stimulating factor 1 receptor
    Protein Accession:
    P07333
    Secondary Accessions:
    • B5A955
    • D3DQG2
    • Q6LDW5
    • Q6LDY4
    • Q86VW7

    Protein attributes for CSF1R Gene

    Size:
    972 amino acids
    Molecular mass:
    107984 Da
    Quaternary structure:
    • Interacts with INPPL1/SHIP2 and THOC5 (By similarity). Monomer. Homodimer. Interacts with CSF1 and IL34. Interaction with dimeric CSF1 or IL34 leads to receptor homodimerization. Interacts (tyrosine phosphorylated) with PLCG2 (via SH2 domain). Interacts (tyrosine phosphorylated) with PIK3R1 (via SH2 domain). Interacts (tyrosine phosphorylated) with FYN, YES1 and SRC (via SH2 domain). Interacts (tyrosine phosphorylated) with CBL, GRB2 and SLA2.

    Three dimensional structures from OCA and Proteopedia for CSF1R Gene

    Alternative splice isoforms for CSF1R Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CSF1R Gene

Proteomics data for CSF1R Gene at MOPED

Post-translational modifications for CSF1R Gene

  • Autophosphorylated in response to CSF1 or IL34 binding. Phosphorylation at Tyr-561 is important for normal down-regulation of signaling by ubiquitination, internalization and degradation. Phosphorylation at Tyr-561 and Tyr-809 is important for interaction with SRC family members, including FYN, YES1 and SRC, and for subsequent activation of these protein kinases. Phosphorylation at Tyr-699 and Tyr-923 is important for interaction with GRB2. Phosphorylation at Tyr-723 is important for interaction with PIK3R1. Phosphorylation at Tyr-708 is important for normal receptor degradation. Phosphorylation at Tyr-723 and Tyr-809 is important for interaction with PLCG2. Phosphorylation at Tyr-969 is important for interaction with CBL. Dephosphorylation by PTPN2 negatively regulates downstream signaling and macrophage differentiation.
  • Ubiquitinated. Becomes rapidly polyubiquitinated after autophosphorylation, leading to its degradation.
  • Ubiquitination at Lys 586, Lys 812, and Lys 870
  • Glycosylation at Asn 45, Asn 73, Asn 153, Asn 240, Asn 275, Asn 302, Asn 335, Asn 353, Asn 412, Asn 428, and Asn 480
  • Modification sites at PhosphoSitePlus

Other Protein References for CSF1R Gene

Antibody Products

  • R&D Systems Antibodies for CSF1R (M-CSF R/CD115)
  • Cell Signaling Technology (CST) Antibodies for CSF1R (CSFR)

Domains & Families for CSF1R Gene

Graphical View of Domain Structure for InterPro Entry

P07333

UniProtKB/Swiss-Prot:

CSF1R_HUMAN :
  • The juxtamembrane domain functions as autoinhibitory region. Phosphorylation of tyrosine residues in this region leads to a conformation change and activation of the kinase.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
Domain:
  • The juxtamembrane domain functions as autoinhibitory region. Phosphorylation of tyrosine residues in this region leads to a conformation change and activation of the kinase.
  • The activation loop plays an important role in the regulation of kinase activity. Phosphorylation of tyrosine residues in this region leads to a conformation change and activation of the kinase.
  • Contains 5 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
genes like me logo Genes that share domains with CSF1R: view

Function for CSF1R Gene

Molecular function for CSF1R Gene

GENATLAS Biochemistry:
colony-stimulating factor 1 (macrophage),receptor
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Present in an inactive conformation in the absence of bound ligand. CSF1 or IL34 binding leads to dimerization and activation by autophosphorylation on tyrosine residues. Inhibited by imatinib/STI-571 (Gleevec), dasatinib, sunitinib/SU11248, lestaurtinib/CEP-701, midostaurin/PKC-412, Ki20227, linifanib/ABT-869, Axitinib/AG013736, sorafenib/BAY 43-9006 and GW2580.
UniProtKB/Swiss-Prot Function:
Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion. Activates several signaling pathways in response to ligand binding. Phosphorylates PIK3R1, PLCG2, GRB2, SLA2 and CBL. Activation of PLCG2 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, that then lead to the activation of protein kinase C family members, especially PRKCD. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to activation of the AKT1 signaling pathway. Activated CSF1R also mediates activation of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1, and of the SRC family kinases SRC, FYN and YES1. Activated CSF1R transmits signals both via proteins that directly interact with phosphorylated tyrosine residues in its intracellular domain, or via adapter proteins, such as GRB2. Promotes activation of STAT family members STAT3, STAT5A and/or STAT5B. Promotes tyrosine phosphorylation of SHC1 and INPP5D/SHIP-1. Receptor signaling is down-regulated by protein phosphatases, such as INPP5D/SHIP-1, that dephosphorylate the receptor and its downstream effectors, and by rapid internalization of the activated receptor.
UniProtKB/Swiss-Prot Induction:
Up-regulated by glucocorticoids.

Enzyme Numbers (IUBMB) for CSF1R Gene

Gene Ontology (GO) - Molecular Function for CSF1R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004713 protein tyrosine kinase activity IEA --
genes like me logo Genes that share ontologies with CSF1R: view
genes like me logo Genes that share phenotypes with CSF1R: view

Human Phenotype Ontology for CSF1R Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CSF1R Gene

MGI Knock Outs for CSF1R:

Animal Model Products

miRNA for CSF1R Gene

miRTarBase miRNAs that target CSF1R

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for CSF1R Gene

Localization for CSF1R Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSF1R Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CSF1R Gene COMPARTMENTS Subcellular localization image for CSF1R gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytoskeleton 2
cytosol 2
endoplasmic reticulum 2
lysosome 2
nucleus 2
vacuole 2
endosome 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CSF1R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with CSF1R: view

Pathways & Interactions for CSF1R Gene

genes like me logo Genes that share pathways with CSF1R: view

SIGNOR curated interactions for CSF1R Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for CSF1R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IMP 20504948
GO:0006468 protein phosphorylation IEA --
GO:0006954 inflammatory response TAS 19132917
GO:0007165 signal transduction TAS 8981357
GO:0007275 multicellular organism development TAS 8981357
genes like me logo Genes that share ontologies with CSF1R: view

Drugs & Compounds for CSF1R Gene

(46) Drugs for CSF1R Gene - From: DGIdb, Novoseek, HMDB, IUPHAR, ApexBio, DrugBank, ClinicalTrials, and FDA Approved Drugs

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sunitinib Approved, Investigational Pharma inhibitor, Target, other/unknown VEGFR/PDGFRβ/ KIT/ FLT3/RET/CSF-1R inhibitor, RTK inhibitor, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors, Potent VEGFR, PDGFRbeta and KIT inhibitor 486
imatinib Approved Pharma inhibitor, Target, antagonist Kinase Inhibitors, SRC/BCR-ABL tyrosine kinase inhibitors 0
Dasatinib Approved, Investigational Pharma Inhibition, inhibitor Kinase Inhibitors, SRC/BCR-ABL tyrosine kinase inhibitors 268
Gleevec Approved May 2001 Pharma 0
Sutent Approved May 2011/ Approved January 2006 Pharma 0

(24) Additional Compounds for CSF1R Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
N-desmethylimatinib
  • CGP74588
genes like me logo Genes that share compounds with CSF1R: view

Drug Products

Transcripts for CSF1R Gene

Unigene Clusters for CSF1R Gene

Colony stimulating factor 1 receptor:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CSF1R Gene

No ASD Table

Relevant External Links for CSF1R Gene

GeneLoc Exon Structure for
CSF1R
ECgene alternative splicing isoforms for
CSF1R

Expression for CSF1R Gene

mRNA expression in normal human tissues for CSF1R Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CSF1R Gene

This gene is overexpressed in Spleen (x9.3) and Whole Blood (x4.5).

Protein differential expression in normal tissues from HIPED for CSF1R Gene

This gene is overexpressed in Serum (19.6), Cerebrospinal fluid (12.4), Plasma (10.7), and Vitreous humor (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CSF1R Gene



SOURCE GeneReport for Unigene cluster for CSF1R Gene Hs.586219

mRNA Expression by UniProt/SwissProt for CSF1R Gene

P07333-CSF1R_HUMAN
Tissue specificity: Expressed in bone marrow and in differentiated blood mononuclear cells.
genes like me logo Genes that share expression patterns with CSF1R: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for CSF1R Gene

Orthologs for CSF1R Gene

This gene was present in the common ancestor of chordates.

Orthologs for CSF1R Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CSF1R 36
  • 100 (a)
OneToOne
CSF1R 35
  • 98.28 (n)
  • 98.21 (a)
cow
(Bos Taurus)
Mammalia CSF1R 35
  • 85.32 (n)
  • 83.8 (a)
CSF1R 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CSF1R 36
  • 85 (a)
OneToOne
CSF1R 35
  • 85.96 (n)
  • 84.47 (a)
mouse
(Mus musculus)
Mammalia Csf1r 16
Csf1r 36
  • 75 (a)
OneToOne
Csf1r 35
  • 79.7 (n)
  • 75.81 (a)
oppossum
(Monodelphis domestica)
Mammalia CSF1R 36
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CSF1R 36
  • 44 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Csf1r 35
  • 79.78 (n)
  • 77.96 (a)
chicken
(Gallus gallus)
Aves CSF1R 36
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CSF1R 36
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia csf1r 35
  • 54.04 (n)
  • 47.99 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.31 35
zebrafish
(Danio rerio)
Actinopterygii csf1r 35
csf1ra 35
  • 54.19 (n)
  • 47.29 (a)
csf1ra 36
  • 44 (a)
OneToMany
csf1rb 36
  • 37 (a)
OneToMany
Species with no ortholog for CSF1R:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CSF1R Gene

ENSEMBL:
Gene Tree for CSF1R (if available)
TreeFam:
Gene Tree for CSF1R (if available)

Paralogs for CSF1R Gene

(10) SIMAP similar genes for CSF1R Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with CSF1R: view

Variants for CSF1R Gene

Sequence variations from dbSNP and Humsavar for CSF1R Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs114792 -- 150,081,390(-) AATAC(A/G)TCCAC intron-variant
rs216123 -- 150,080,990(+) AGCTC(A/G)GGGAC nc-transcript-variant, reference, synonymous-codon
rs216124 -- 150,082,446(+) AAACG(A/G)GATTG intron-variant
rs216146 -- 150,066,358(+) CATCA(C/T)CCCAT intron-variant
rs216147 -- 150,066,865(+) CCCCA(A/G)CCCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CSF1R Gene

Variant ID Type Subtype PubMed ID
nsv830518 CNV Loss 17160897
nsv528113 CNV Loss 19592680
nsv528188 CNV Gain 19592680
esv2504567 CNV Deletion 19546169
esv2355903 CNV Deletion 18987734
esv2730911 CNV Deletion 23290073
esv2661063 CNV Deletion 23128226
esv22778 CNV Gain+Loss 19812545
nsv523125 CNV Loss 19592680
dgv6359n71 CNV Loss 21882294
nsv883027 CNV Loss 21882294
nsv883028 CNV Loss 21882294

Variation tolerance for CSF1R Gene

Residual Variation Intolerance Score: 44.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.06; 75.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CSF1R Gene

HapMap Linkage Disequilibrium report
CSF1R
Human Gene Mutation Database (HGMD)
CSF1R

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSF1R Gene

Disorders for CSF1R Gene

MalaCards: The human disease database

(25) MalaCards diseases for CSF1R Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search CSF1R in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

CSF1R_HUMAN
  • Note=Aberrant expression of CSF1 or CSF1R can promote cancer cell proliferation, invasion and formation of metastases. Overexpression of CSF1 or CSF1R is observed in a significant percentage of breast, ovarian, prostate, and endometrial cancers.
  • Note=Aberrant expression of CSF1 or CSF1R may play a role in inflammatory diseases, such as rheumatoid arthritis, glomerulonephritis, atherosclerosis, and allograft rejection.
  • Leukoencephalopathy, diffuse hereditary, with spheroids (HDLS) [MIM:221820]: An autosomal dominant adult-onset rapidly progressive neurodegenerative disorder characterized by variable behavioral, cognitive, and motor changes. Patients often die of dementia within 6 years of onset. Brain imaging shows patchy abnormalities in the cerebral white matter, predominantly affecting the frontal and parietal lobes. {ECO:0000269 PubMed:22197934, ECO:0000269 PubMed:24532199}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for CSF1R

Genetic Association Database (GAD)
CSF1R
Human Genome Epidemiology (HuGE) Navigator
CSF1R
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CSF1R
genes like me logo Genes that share disorders with CSF1R: view

No data available for Genatlas for CSF1R Gene

Publications for CSF1R Gene

  1. Inhibition of phosphorylation of the colony-stimulating factor-1 receptor (c-Fms) tyrosine kinase in transfected cells by ABT-869 and other tyrosine kinase inhibitors. (PMID: 16648572) Guo J. … Glaser K.B. (Mol. Cancer Ther. 2006) 3 4 23 25 26 67
  2. Imatinib mesylate inhibits osteoclastogenesis and joint destruction in rats with collagen-induced arthritis (CIA). (PMID: 16816921) Ando W. … Yoshikawa H. (J. Bone Miner. Metab. 2006) 23 25 26
  3. FMS receptor for M-CSF (CSF-1) is sensitive to the kinase inhibitor imatinib and mutation of Asp-802 to Val confers resistance. (PMID: 16170366) Taylor J.R. … Dibb N.J. (Oncogene 2006) 3 25 26
  4. Inhibition of c-fms by imatinib: expanding the spectrum of treatment. (PMID: 15917650) Dewar A.L. … Lyons A.B. (Cell Cycle 2005) 23 25 26
  5. c-Fms-mediated differentiation and priming of monocyte lineage cells play a central role in autoimmune arthritis. (PMID: 20181277) Paniagua R.T. … Robinson W.H. (Arthritis Res. Ther. 2010) 3 23

Products for CSF1R Gene

  • Addgene plasmids for CSF1R

Sources for CSF1R Gene

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