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Aliases for CSE1L Gene

Aliases for CSE1L Gene

  • CSE1 Chromosome Segregation 1-Like (Yeast) 2 3
  • CAS 3 4 6
  • Cellular Apoptosis Susceptibility Protein 3 4
  • Chromosome Segregation 1-Like Protein 3 4
  • Importin-Alpha Re-Exporter 3 4
  • Exp2 3 4
  • XPO2 3 4
  • Chromosome Segregation 1 (Yeast Homolog)-Like 2
  • Cellular Apoptosis Susceptibility 2
  • Exportin-2 3
  • CSE1 3

External Ids for CSE1L Gene

Previous GeneCards Identifiers for CSE1L Gene

  • GC20P047391
  • GC20P048302
  • GC20P048348
  • GC20P047096
  • GC20P047662
  • GC20P044412

Summaries for CSE1L Gene

Entrez Gene Summary for CSE1L Gene

  • Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]

GeneCards Summary for CSE1L Gene

CSE1L (CSE1 Chromosome Segregation 1-Like (Yeast)) is a Protein Coding gene. Among its related pathways are Direct p53 effectors and p53 pathway. GO annotations related to this gene include Ran GTPase binding and importin-alpha export receptor activity.

UniProtKB/Swiss-Prot for CSE1L Gene

  • Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSE1L Gene

Genomics for CSE1L Gene

Regulatory Elements for CSE1L Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CSE1L Gene

Start:
49,046,246 bp from pter
End:
49,096,960 bp from pter
Size:
50,715 bases
Orientation:
Plus strand

Genomic View for CSE1L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CSE1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSE1L Gene

Proteins for CSE1L Gene

  • Protein details for CSE1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55060-XPO2_HUMAN
    Recommended name:
    Exportin-2
    Protein Accession:
    P55060
    Secondary Accessions:
    • A3RLL6
    • B2R5T4
    • E1P5Y0
    • F8W904
    • O75432
    • Q32M40
    • Q9H5B7
    • Q9NTS0
    • Q9UP98
    • Q9UP99
    • Q9UPA0

    Protein attributes for CSE1L Gene

    Size:
    971 amino acids
    Molecular mass:
    110417 Da
    Quaternary structure:
    • Found in a complex with CSE1L/XPO2, Ran and KPNA2. Binds with high affinity to importin-alpha only in the presence of RanGTP. The complex is dissociated by the combined action of RanBP1 and RanGAP1.

    Alternative splice isoforms for CSE1L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CSE1L Gene

Proteomics data for CSE1L Gene at MOPED

Post-translational modifications for CSE1L Gene

  • Ubiquitination at Lys165, Lys440, Lys726, Lys824, Lys925, and Lys934
  • Modification sites at PhosphoSitePlus

Other Protein References for CSE1L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CSE1L Gene

Domains for CSE1L Gene

Gene Families for CSE1L Gene

HGNC:
  • XPO :Exportins

Graphical View of Domain Structure for InterPro Entry

P55060

UniProtKB/Swiss-Prot:

XPO2_HUMAN :
  • P55060
Domain:
  • Contains 1 importin N-terminal domain.
Family:
  • Belongs to the XPO2/CSE1 family.
genes like me logo Genes that share domains with CSE1L: view

Function for CSE1L Gene

Molecular function for CSE1L Gene

GENATLAS Biochemistry: cellular apoptosis susceptibility gene (CAS),human homolog of the yeast chromosome segregation gene 1 (CSE1),highly expressed in proliferating tissues,involved in the cell cycle of mammalian cells and in apoptosis,transport factor necessary for recycling of importin-alpha from the nucleus to the cytoplasm
UniProtKB/Swiss-Prot Function: Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

Gene Ontology (GO) - Molecular Function for CSE1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding IPI 17719542
GO:0008262 importin-alpha export receptor activity TAS 9323134
GO:0008536 Ran GTPase binding IEA --
genes like me logo Genes that share ontologies with CSE1L: view
genes like me logo Genes that share phenotypes with CSE1L: view

Animal Models for CSE1L Gene

MGI Knock Outs for CSE1L:

Animal Model Products

CRISPR Products

miRNA for CSE1L Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CSE1L

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CSE1L Gene

Localization for CSE1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSE1L Gene

Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CSE1L Gene COMPARTMENTS Subcellular localization image for CSE1L gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CSE1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 9323134
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0016020 membrane IDA 19946888
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with CSE1L: view

Pathways for CSE1L Gene

genes like me logo Genes that share pathways with CSE1L: view

Pathways by source for CSE1L Gene

2 BioSystems pathways for CSE1L Gene
1 GeneGo (Thomson Reuters) pathway for CSE1L Gene

Gene Ontology (GO) - Biological Process for CSE1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006611 protein export from nucleus TAS 9323134
GO:0006886 intracellular protein transport --
GO:0006915 apoptotic process TAS 7479798
GO:0008283 cell proliferation TAS 7479798
genes like me logo Genes that share ontologies with CSE1L: view

Compounds for CSE1L Gene

(1) HMDB Compounds for CSE1L Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with CSE1L: view

Transcripts for CSE1L Gene

Unigene Clusters for CSE1L Gene

CSE1 chromosome segregation 1-like (yeast):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CSE1L

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CSE1L

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CSE1L Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1: -
SP2: - -
SP3:
SP4:
SP5: -
SP6:

ExUns: 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b · 25c
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for CSE1L Gene

GeneLoc Exon Structure for
CSE1L
ECgene alternative splicing isoforms for
CSE1L

Expression for CSE1L Gene

mRNA expression in normal human tissues for CSE1L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CSE1L Gene

SOURCE GeneReport for Unigene cluster for CSE1L Gene Hs.90073

mRNA Expression by UniProt/SwissProt for CSE1L Gene

P55060-XPO2_HUMAN
Tissue specificity: Highly expressed in proliferating cells
genes like me logo Genes that share expressions with CSE1L: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CSE1L Gene

Orthologs for CSE1L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CSE1L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CSE1L 35
  • 99.9 (n)
  • 100 (a)
CSE1L 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CSE1L 35
  • 93.58 (n)
  • 99.69 (a)
CSE1L 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CSE1L 35
  • 94.68 (n)
  • 99.79 (a)
CSE1L 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cse1l 35
  • 89.53 (n)
  • 99.07 (a)
Cse1l 16
Cse1l 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CSE1L 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CSE1L 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cse1l 35
  • 89.08 (n)
  • 98.35 (a)
chicken
(Gallus gallus)
Aves CSE1L 35
  • 84.17 (n)
  • 95.47 (a)
CSE1L 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CSE1L 36
  • 94 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.11576 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cse1l 35
  • 77.1 (n)
  • 88.36 (a)
Str.7149 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5928 35
zebrafish
(Danio rerio)
Actinopterygii cse1l 35
cse1l 35
  • 73.7 (n)
  • 86.71 (a)
cse1l 36
  • 87 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010711 35
  • 55.24 (n)
  • 55.9 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cas 35
  • 54.77 (n)
  • 52.86 (a)
Cas 36
  • 52 (a)
OneToOne
Cas 37
  • 51 (a)
worm
(Caenorhabditis elegans)
Secernentea xpo-2 36
  • 31 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR273W 35
  • 47.54 (n)
  • 37.33 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CSE1 35
  • 49.77 (n)
  • 39.19 (a)
CSE1 36
  • 36 (a)
OneToOne
CSE1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A00869g 35
  • 48.11 (n)
  • 37.16 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G46520 35
  • 48.12 (n)
  • 40.02 (a)
rice
(Oryza sativa)
Liliopsida Os01g0235400 35
  • 45.39 (n)
  • 35.35 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04104 35
  • 44.36 (n)
  • 34.37 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes kap109 35
  • 49.39 (n)
  • 40.22 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3837 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10467 36
  • 62 (a)
OneToOne
Species with no ortholog for CSE1L:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CSE1L Gene

ENSEMBL:
Gene Tree for CSE1L (if available)
TreeFam:
Gene Tree for CSE1L (if available)

Paralogs for CSE1L Gene

No data available for Paralogs for CSE1L Gene

Variants for CSE1L Gene

Sequence variations from dbSNP and Humsavar for CSE1L Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs3505 - 49,096,424(-) TGTCA(C/G)ACTGG missense, reference, nc-transcript-variant
rs11965 -- 49,096,400(+) ATCTC(C/G)AAGGG reference, missense, nc-transcript-variant
rs17632 -- 49,096,526(+) AAGTT(C/T)TCCTT utr-variant-3-prime, nc-transcript-variant
rs1014844 -- 49,061,030(+) AAAGT(A/C)TTTGT intron-variant
rs1014845 -- 49,061,049(+) AGAGG(A/T)AAAAT intron-variant

Relevant External Links for CSE1L Gene

HapMap Linkage Disequilibrium report
CSE1L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CSE1L Gene

Disorders for CSE1L Gene

(7) Novoseek inferred disease relationships for CSE1L Gene

Disease -log(P) Hits PubMed IDs
colon cancer 34.9 5
breast cancer 25.7 5
hepatocellular carcinoma 15.3 3
carcinoma 12.2 2
necrosis 6.06 3

Relevant External Links for CSE1L

Genetic Association Database (GAD)
CSE1L
genes like me logo Genes that share disorders with CSE1L: view

No data available for UniProtKB/Swiss-Prot for CSE1L Gene

Publications for CSE1L Gene

  1. Cloning and characterization of a cellular apoptosis susceptibility gene, the human homologue to the yeast chromosome segregation gene CSE1. (PMID: 7479798) Brinkmann U. … Pastan I. (Proc. Natl. Acad. Sci. U.S.A. 1995) 2 3 4 23
  2. Tissue-specific alternative splicing of the CSE1L/CAS (cellular apoptosis susceptibility) gene. (PMID: 10331944) Brinkmann U. … Pastan I. (Genomics 1999) 3 4 23
  3. The human CAS (cellular apoptosis susceptibility) gene mapping on chromosome 20q13 is amplified in BT474 breast cancer cells and part of aberrant chromosomes in breast and colon cancer cell lines. (PMID: 8963895) Brinkmann U. … Pastan I. (Genome Res. 1996) 2 3 23
  4. High expression of the proliferation and apoptosis associated CSE1L/CAS gene in hepatitis and liver neoplasms: correlation with tumor progression. (PMID: 11295109) Wellmann A. … Brinkmann U. (Int. J. Mol. Med. 2001) 3 23
  5. Role of CAS, a human homologue to the yeast chromosome segregation gene CSE1, in toxin and tumor necrosis factor mediated apoptosis. (PMID: 8639641) Brinkmann U. … Pastan I. (Biochemistry 1996) 3 23

Products for CSE1L Gene

Sources for CSE1L Gene

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