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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CSE1L Gene

protein-coding   GIFtS: 63
GCID: GC20P047662

CSE1 chromosome segregation 1-like (yeast)

(Previous name: chromosome segregation 1 (yeast homolog)-like )
 Explore 10 diseases affiliated with
CSE1L via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CSE1L    

Aliases
for CSE1L gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
CSE1 Chromosome Segregation 1-Like (Yeast)1 2     Importin-Alpha Re-Exporter2 3
CAS1 2 3 5     Chromosome Segregation 1 (Yeast Homolog)-Like1
XPO21 2 3     Exp23
CSE11 2     Exportin-21
Cellular Apoptosis Susceptibility Protein2 3     Exp23
Chromosome Segregation 1-Like Protein2 3     

External Ids:    HGNC: 24311   Entrez Gene: 14342   Ensembl: ENSG000001242077   OMIM: 6013425   UniProtKB: P550603   

Export aliases for CSE1L gene to outside databases

Previous GC identifers: GC20P047391 GC20P048302 GC20P048348 GC20P047096 GC20P044412


Summaries
for CSE1L gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CSE1L:
Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta
heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore
complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be
returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free
importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In
addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced
transcript variants have been found for this gene. (provided by RefSeq, Jan 2012)

UniProtKB/Swiss-Prot: XPO2_HUMAN, P55060
Function: Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after
import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to
importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear
pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the
cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1,
respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear
compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by
an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus




Genomic Views
for CSE1L gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.1  NT_011362.10  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CSE1L gene promoter:
         Sp1   Pax-6   HNF-4alpha2   E4BP4   Ik-3   FOXL1   Gfi-1   HNF-4alpha1   HFH-1   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): CSE1L promoter sequence
   Search SABiosciences Chromatin IP Primers for CSE1L

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CSE1L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13   Ensembl cytogenetic band:  20q13.13   HGNC cytogenetic band: 20q13

CSE1L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CSE1L gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P047662:  view genomic region     (about GC identifiers)

Start:
 47,662,838 bp from pter      End:
 47,713,489 bp from pter
Size:
 50,652 bases      Orientation:
 plus strand

Proteins
for CSE1L gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: XPO2_HUMAN, P55060 (See protein sequence)
Recommended Name: Exportin-2  
Size: 971 amino acids; 110417 Da
Subunit: Found in a complex with CSE1L/XPO2, Ran and KPNA2. Binds with high affinity to importin-alpha only in the
presence of RanGTP. The complex is dissociated by the combined action of RanBP1 and RanGAP1
Subcellular location: Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm
Secondary accessions: B2R5T4 E1P5Y0 O75432 Q32M40 Q9H5B7 Q9NTS0 Q9UP98 Q9UP99 Q9UPA0
Alternative splicing: 3 isoforms:  P55060-1   P55060-2   P55060-3   

Explore the universe of human proteins at neXtProt for CSE1L: NX_P55060

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P55060

    • CSE1L Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001243064.1  NP_001307.2  

    ENSEMBL proteins: 
     ENSP00000262982   ENSP00000379495   ENSP00000446477  

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    Uscn Proteins for CSE1L

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus TAS9323134
    GO:0005643nuclear pore IEA--
    GO:0005737cytoplasm IEA--


    CSE1L for ontologies           About GeneDecksing



    CSE1L Antibody Products: 
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    Uscn ELISAs and CLIAs for CSE1L

    Protein Domains /
    Families
    for CSE1L gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CSE1L for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR011989 ARM-like
     IPR013713 Exportin/Importin_Cse1-like
     IPR001494 Importin-beta_N
     IPR005043 CAS_CSE1_C
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry P55060

    ProtoNet protein and cluster: P55060

    2 Blocks protein families:
    IPB001494 Importin-beta
    IPB005043 CAS/CSE protein C-terminal


    UniProtKB/Swiss-Prot: XPO2_HUMAN, P55060
    Similarity: Belongs to the XPO2/CSE1 family
    Similarity: Contains 1 importin N-terminal domain


    Function
    for CSE1L gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: XPO2_HUMAN, P55060
    Function: Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after
    import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to
    importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear
    pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the
    cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1,
    respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear
    compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by
    an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus

         Genatlas biochemistry entry for CSE1L:
    cellular apoptosis susceptibility gene (CAS),human homolog of the yeast chromosome segregation gene 1 (CSE1),highly
    expressed in proliferating tissues,involved in the cell cycle of mammalian cells and in apoptosis,transport factor
    necessary for recycling of importin-alpha from the nucleus to the cytoplasm

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmid: CSE1L 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: CSE1L
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17719542
    GO:0008262importin-alpha export receptor activity TAS9323134
    GO:0008565protein transporter activity ----


    CSE1L for ontologies           About GeneDecksing


    7 GenomeRNAi human phenotypes for CSE1L:
     Decreased viability  Decreased viability of wild-ty  Increased cell death in HCT116  Increased circadian period len 
     Synthetic lethal with Ras  Synthetic lethal with gemcitab  Upregulation of Wnt/beta-caten 

    Animal Models:
         Mouse knock-out Cse1ltmIpa for CSE1L
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Cse1l):
     embryogenesis  growth/size  mortality/aging 

    CSE1L for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CSE1L gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cell cycle_Spindle assembly and chromosome separation
    		Cell cycle_Spindle assembly and chromosome separation1.00
    		Cell cycle Spindle assembly and chromosome separation0.94
    2p53 pathway
    		p53 pathway1.00
    3Direct p53 effectors
    		Direct p53 effectors1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for CSE1L
        Cell cycle Spindle assembly and chromosome separation


    1 GeneGo (Thomson Reuters) Pathway for CSE1L
        Cell cycle Spindle assembly and chromosome separation

    2 BioSystems Pathways for CSE1L 
        Direct p53 effectors
    p53 pathway



    CSE1L for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CSE1L

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/823 Interacting proteins for CSE1L (P550601, 2, 3 ENSP000002629824) via UniProtKB, MINT, STRING, and/or I2D (see all 823)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KPNA2P522922, 3, ENSP000003324554MINT-7945693 MINT-7947479 I2D: score=6 STRING: ENSP00000332455
    RPL22P352682, 3MINT-7945693 MINT-7947479 MINT-63688 I2D: score=5 
    PPP5CP530412, 3, ENSP000000124434MINT-63867 I2D: score=5 STRING: ENSP00000012443
    ENSG00000258947Q135092, 3MINT-7945693 I2D: score=2 
    RPLP0P053882, 3MINT-7945693 MINT-7947479 I2D: score=2 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport ----
    GO:0006915apoptotic process TAS7479798
    GO:0008283cell proliferation TAS7479798


    CSE1L for ontologies           About GeneDecksing



    Drugs & Compounds
    for CSE1L gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CSE1L

    1 HMDB Compound for CSE1L    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    Search CenterWatch for drugs/clinical trials and news about CSE1L / XPO2 

    Transcripts
    for CSE1L gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CSE1L gene (3 alternative transcripts): 
    NM_001256135.1  NM_001316.3  NM_177436.1  

    Unigene Cluster for CSE1L:

    CSE1 chromosome segregation 1-like (yeast)
    Hs.90073  [show with all ESTs]
    Unigene Representative Sequence: NM_001316
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000262982(uc002xty.3 uc010zyg.2 uc010ghx.3 uc010ghy.3 uc010zyh.2)
    ENST00000476393 ENST00000469700 ENST00000396192 ENST00000542325

    miRNA
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    hsa-miR-137 hsa-miR-9* hsa-miR-889
    SwitchGear 3'UTR luciferase reporter plasmid: CSE1L 3' UTR sequence
    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AF053641.1 AF053642.1 AK098618.1 AK225610.1 AK297270.1 AK297314.1 AK298477.1 AK299549.1 
    AK300589.1 AK307965.1 AK312306.1 BC108309.1 BC109313.2 BC109314.2 EF426455.1 NR_045796.1 
    U33286.1 

    24/36 DOTS entries (see all 36):

    DT.449960  DT.100726211  DT.100846592  DT.100678362  DT.95337904  DT.120805567  DT.120805552  DT.95279266 
    DT.100678360  DT.95279309  DT.100678361  DT.100678368  DT.40133298  DT.95279306  DT.120805573  DT.95279317 
    DT.100678357  DT.120805600  DT.100038098  DT.120805590  DT.86821338  DT.100038099  DT.100678352  DT.100678353 

    24/574 AceView cDNA sequences (see all 574):

    AW472844 BM837121 AI344110 BM453546 AI973168 AF053642 CB140685 AA164700 
    AI753243 BI858358 BQ430663 BQ221808 BU177239 AU141925 AI826239 CB118931 
    BG574979 AW303874 BU507290 AA243317 BM473830 CB140990 CB113091 BP373536 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CSE1L (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
    SP1:                                                                    -                                                                                       
    SP2:                                                                    -                 -                                                                     
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                          -                                                                                                                                 

    ExUns: 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b · 25c
    SP1:                                      -               
    SP2:                                                      
    SP3:                                                      
    SP4:                                                      
    SP5:                                                      


    ECgene alternative splicing isoforms for CSE1L

    Expression
    for CSE1L gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CSE1L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATCCTGTAGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CSE1L expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainCerebral CortexBrain
    KidneyMetanephrosKidney
    Neural TubeTelencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CSE1L Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CSE1L

    SOURCE GeneReport for Unigene cluster: Hs.90073

    UniProtKB/Swiss-Prot: XPO2_HUMAN, P55060
    Tissue specificity: Highly expressed in proliferating cells

        SABiosciences Custom PCR Arrays for CSE1L
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    In Situ
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    Orthologs
    for CSE1L gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CSE1L gene from 10/36 species (see all 36)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Cse1l1 , 5 chromosome segregation 1-like (S. cerevisiae)1, 5 89.53(n)1
    99.07(a)1    		   2 (87.22 cM)5
    1107501  NM_023565.31  NP_076054.11 
     1669060405 
    chicken
    (Gallus gallus)    		 Aves CSE1L1 CSE1 chromosome segregation 1-like (yeast) 84.17(n)
    95.47(a)    		   419212  XM_417389.3  XP_417389.3 
    lizard
    (Anolis carolinensis)    		 Reptilia CSE1L6
    		 --
    		 94(a)
    		 1 ↔ 1
    		 4(146382277-146402950)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.115762 Xenopus laevis transcribed sequence with moderate similarity to protein pirI39166 (H.sapiens) I39166 cellular apoptosis susceptibility protein CAS - human less 76.19(n)    CA791518.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii cse1l2 Danio rerio similar to cellular apoptosis susceptibility gene product, mRNA (cDNA clone MGC55932 IMAGE3819210), complete cds less 76.15(n)    BC052479.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Cas1 , 3 apoptosis importin-alpha export receptor3
    CAS/CSE1 segregation protein1    		 51(a)3
    54.52(n)1
    52.38(a)1    		   350161  NM_078864.21  NP_523588.21 
    worm
    (Caenorhabditis elegans)    		 Secernentea xpo-26
    		 eXPOrtin (nuclear export receptor) family member (...
    		 29(a)
    		 1 ↔ 1
    		 I(318543-323353)
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes CSE1(YGL238W)4
    CSE11    		 Nuclear envelope protein that mediates the nuclear export of importin alpha (Srp1p), homolog of metazoan CAS protein, required for accurate chromosome segregation less4
    Cse1p1    		 49.14(n)1
    38.2(a)1    		   7(49552-52434)4
    8526121, 4  NP_011276.11, 4 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT2G465201 exportin-2 48.2(n)
    40.34(a)    		   819263  NM_130217.3  NP_182175.1 
    rice
    (Oryza sativa)    		 Liliopsida Os01g02354001 hypothetical protein 45.21(n)
    34.46(a)    		   4327779  NM_001049057.1  NP_001042522.1 


    ENSEMBL Gene Tree for CSE1L (if available)
    TreeFam Gene Tree for CSE1L (if available) 

    Paralogs
    for CSE1L gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for CSE1L gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1015 NCBI SNPs in CSE1L are shown (see all 1015)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 20 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1893060331,2
    		--47660783(+) TAAGCA/GGCTAC 3 -- us2k10--------
    rs1923411361,2
    		--47660801(+) CTAGTA/GCTGGG 3 -- us2k10--------
    rs1856826541,2
    		--47660920(+) TGGAGG/TGCAAT 3 -- us2k10--------
    rs575193991,2
    		--47660994(+) TCCCAA/CGTAGC 3 -- us2k10--------
    rs30925181,2
    		C,A,--47661013(+) CAGACC/GTGCGC 3 -- us2k11Minor allele frequency- G:0.00NA 2
    rs1385155021,2
    		--47661160(+) GCCCAG/TCCCTA 3 -- us2k10--------
    rs1896170291,2
    		--47661185(+) GAGGCA/GGAGGT 3 -- us2k10--------
    rs761903261,2
    		--47661245(+) TCATCC/TCTACA 3 -- us2k11Minor allele frequency- T:0.00NA 2
    rs759320541,2
    		--47661246(+) CATCTT/CTACAA 3 -- us2k11Minor allele frequency- C:0.00NA 2
    rs1441003711,2
    		--47661342(+) TAGGAA/GGTCGA 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for CSE1L (47662838 - 47713489 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CSE1L: --

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    Disorders / Diseases
    for CSE1L gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CSE1L for disorders           About GeneDecksing

    OMIM gene information: 601342    OMIM disorders: --

    10 diseases for CSE1L:    About MalaCards
    nevus    hepatocellular carcinoma    colon cancer    colon adenocarcinoma
    breast cancer    colorectal cancer    adenocarcinoma    carcinoma
    hepatitis    malaria

    7 Novoseek disease relationships for CSE1L gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colon cancer 34.9 6 8963895 (3), 15354419 (2)
    breast cancer 25.7 7 8963895 (4), 12510150 (1)
    hepatocellular carcinoma 15.3 4 11295109 (2), 16786158 (1)
    carcinoma 12.2 2 15354419 (1), 11295109 (1)
    necrosis 6.06 4 8639641 (2), 16786158 (1)
    tumors 4.22 7 11295109 (2), 8639641 (2), 16786158 (1), 12510150 (1)
    cancer 0 7 12510150 (3), 17550137 (1), 15354419 (1), 11724300 (1)


    Export disorders for CSE1L gene to outside databases

    Publications
    for CSE1L gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CSE1L gene, integrated from 9 sources (see all 74):
    (articles sorted by number of sources associating them with CSE1L)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a cellular apoptosis susceptibility gene, the human homologue to the yeast chromosome segregation gene CSE1. (PubMed id 7479798)1, 2, 3, 9 Brinkmann U.... Pastan I. (1995)
    2. The human CAS (cellular apoptosis susceptibility) gene mapping on chromosome 20q13 is amplified in BT474 breast cancer cells and part of aberrant chromosomes in breast and colon cancer cell lines. (PubMed id 8963895)1, 3, 9 Brinkmann U....Pastan I. (1996)
    3. Tissue-specific alternative splicing of the CSE1L/CAS (cellular apoptosis susceptibility) gene. (PubMed id 10331944)1, 2, 9 Brinkmann U.... Pastan I. (1999)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    6. Determination of the functional domain organization of the importin alpha nuclear import factor. (PubMed id 9786944)1, 2 Herold A.... Cullen B.R. (1998)
    7. Export of importin-alpha from the nucleus is mediated by a specific nuclear transport factor. (PubMed id 9323134)1, 2 Kutay U.... Goerlich D. (1997)
    8. High expression of the proliferation and apoptosis associated CSE1L/CAS gene in hepatitis and liver neoplasms: correlation with tumor progression. (PubMed id 11295109)1, 9 Wellmann A....Brinkmann U. (2001)
    9. Cellular apoptosis susceptibility protein and proliferation in human hepatocellular carcinoma. (PubMed id 16786158)1, 9 Shiraki K....Nakano T. (2006)
    10. Role of CAS, a human homologue to the yeast chromosome segregation gene CSE1, in toxin and tumor necrosis factor mediated apoptosis. (PubMed id 8639641)1, 9 Brinkmann U....Pastan I. (1996)

    External Searches for CSE1L gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
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    Genome Databases showing CSE1L gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1434 HGNC: 2431 AceView: CSE1L Ensembl:ENSG00000124207 euGenes: HUgn1434
    ECgene: CSE1L H-InvDB: CSE1L

    Other Databases showing CSE1L gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CSE1L gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CSE1L Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CSE1L Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for CSE1L gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CSE1L gene:
    Search GeneIP for patents involving CSE1L

    GeneCards and IP:
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