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Aliases for CSE1L Gene

Aliases for CSE1L Gene

  • Chromosome Segregation 1 Like 2 3 5
  • Cellular Apoptosis Susceptibility Protein 3 4
  • Chromosome Segregation 1-Like Protein 3 4
  • Importin-Alpha Re-Exporter 3 4
  • Exp2 3 4
  • XPO2 3 4
  • CAS 3 4
  • Chromosome Segregation 1 (Yeast Homolog)-Like 2
  • CSE1 Chromosome Segregation 1-Like (Yeast) 2
  • CSE1 Chromosome Segregation 1 Like 2
  • CSE1 Chromosome Segregation 1-Like 3
  • Cellular Apoptosis Susceptibility 2
  • Exportin-2 3
  • CSE1 3

External Ids for CSE1L Gene

Previous GeneCards Identifiers for CSE1L Gene

  • GC20P047391
  • GC20P048302
  • GC20P048348
  • GC20P047096
  • GC20P047662
  • GC20P044412

Summaries for CSE1L Gene

Entrez Gene Summary for CSE1L Gene

  • Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]

GeneCards Summary for CSE1L Gene

CSE1L (Chromosome Segregation 1 Like) is a Protein Coding gene. Diseases associated with CSE1L include Colorectal Cancer. Among its related pathways are p53 pathway (Pathway Interaction Database) and Cell cycle_Spindle assembly and chromosome separation. GO annotations related to this gene include binding.

UniProtKB/Swiss-Prot for CSE1L Gene

  • Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSE1L Gene

Genomics for CSE1L Gene

Regulatory Elements for CSE1L Gene

Enhancers for CSE1L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G049275 2.1 FANTOM5 Ensembl ENCODE dbSUPER 25.6 +233.7 233709 9.2 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF416 ZNF143 CSE1L ZNFX1 ZFAS1 SNORD12B B4GALT5 SNORD12 ARFGEF2 GC20P049304 ENSG00000274760
GH20G048919 1.5 ENCODE dbSUPER 29.4 -123.8 -123751 5.7 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF416 ZNF143 CSE1L ARFGEF2 PREX1 SNORD12B ZFAS1 SPATA2 GC20P048935
GH20G049166 1.5 FANTOM5 Ensembl ENCODE 28.2 +121.1 121127 2.4 PKNOX1 ZFP64 DMAP1 ZNF48 RAD21 ZNF335 ETV6 MIXL1 ZNF263 HMG20B CSE1L PREX1 ZNFX1 PIR47119 STAU1
GH20G048932 1.4 Ensembl ENCODE dbSUPER 28.7 -113.2 -113187 1.8 FOXA2 ARID4B RAD21 RARA YY1 ZNF121 ETV6 BCLAF1 MIXL1 EGR2 CSE1L ARFGEF2 GC20P048935
GH20G049045 1.1 ENCODE 28.8 +0.6 612 3.0 HDGF PKNOX1 MLX AGO1 ZFP64 WRNIP1 SIN3A ARID4B DMAP1 ZNF2 CSE1L ARFGEF2 SNORD12B ZFAS1 SNORD12 GC20P049089
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CSE1L on UCSC Golden Path with GeneCards custom track

Promoters for CSE1L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000138192 554 2001 HDGF PKNOX1 MLX AGO1 WRNIP1 ZFP64 SIN3A ARID4B DMAP1 ZNF2

Genomic Location for CSE1L Gene

Chromosome:
20
Start:
49,046,246 bp from pter
End:
49,096,960 bp from pter
Size:
50,715 bases
Orientation:
Plus strand

Genomic View for CSE1L Gene

Genes around CSE1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CSE1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CSE1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSE1L Gene

Proteins for CSE1L Gene

  • Protein details for CSE1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55060-XPO2_HUMAN
    Recommended name:
    Exportin-2
    Protein Accession:
    P55060
    Secondary Accessions:
    • A3RLL6
    • B2R5T4
    • E1P5Y0
    • F8W904
    • O75432
    • Q32M40
    • Q9H5B7
    • Q9NTS0
    • Q9UP98
    • Q9UP99
    • Q9UPA0

    Protein attributes for CSE1L Gene

    Size:
    971 amino acids
    Molecular mass:
    110417 Da
    Quaternary structure:
    • Found in a complex with CSE1L/XPO2, Ran and KPNA2. Binds with high affinity to importin-alpha only in the presence of RanGTP. The complex is dissociated by the combined action of RanBP1 and RanGAP1.

    Alternative splice isoforms for CSE1L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CSE1L Gene

Post-translational modifications for CSE1L Gene

  • Ubiquitination at Lys165, isoforms=3, 4440, isoforms=3, 4726, isoforms=3, 4824, isoforms=3, 4925, and isoforms=3, 4934
  • Modification sites at PhosphoSitePlus

Other Protein References for CSE1L Gene

No data available for DME Specific Peptides for CSE1L Gene

Domains & Families for CSE1L Gene

Gene Families for CSE1L Gene

Graphical View of Domain Structure for InterPro Entry

P55060

UniProtKB/Swiss-Prot:

XPO2_HUMAN :
  • Belongs to the XPO2/CSE1 family.
Family:
  • Belongs to the XPO2/CSE1 family.
genes like me logo Genes that share domains with CSE1L: view

Function for CSE1L Gene

Molecular function for CSE1L Gene

GENATLAS Biochemistry:
cellular apoptosis susceptibility gene (CAS),human homolog of the yeast chromosome segregation gene 1 (CSE1),highly expressed in proliferating tissues,involved in the cell cycle of mammalian cells and in apoptosis,transport factor necessary for recycling of importin-alpha from the nucleus to the cytoplasm
UniProtKB/Swiss-Prot Function:
Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

Gene Ontology (GO) - Molecular Function for CSE1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005049 nuclear export signal receptor activity TAS 9323134
GO:0005515 protein binding IPI 17719542
GO:0008536 Ran GTPase binding IEA --
genes like me logo Genes that share ontologies with CSE1L: view
genes like me logo Genes that share phenotypes with CSE1L: view

Animal Models for CSE1L Gene

MGI Knock Outs for CSE1L:

Animal Model Products

CRISPR Products

miRNA for CSE1L Gene

miRTarBase miRNAs that target CSE1L

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CSE1L Gene

Localization for CSE1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSE1L Gene

Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CSE1L gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
plasma membrane 1
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for CSE1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 9323134
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm TAS 9323134
GO:0005829 cytosol IDA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with CSE1L: view

Pathways & Interactions for CSE1L Gene

genes like me logo Genes that share pathways with CSE1L: view

Pathways by source for CSE1L Gene

2 BioSystems pathways for CSE1L Gene
1 GeneGo (Thomson Reuters) pathway for CSE1L Gene

Gene Ontology (GO) - Biological Process for CSE1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006611 protein export from nucleus IEA --
GO:0006810 transport IEA --
GO:0006886 intracellular protein transport IEA --
GO:0006915 apoptotic process TAS 7479798
GO:0008283 cell proliferation TAS 7479798
genes like me logo Genes that share ontologies with CSE1L: view

No data available for SIGNOR curated interactions for CSE1L Gene

Drugs & Compounds for CSE1L Gene

(1) Drugs for CSE1L Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with CSE1L: view

Transcripts for CSE1L Gene

Unigene Clusters for CSE1L Gene

CSE1 chromosome segregation 1-like (yeast):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CSE1L Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1: -
SP2: - -
SP3:
SP4:
SP5: -
SP6:

ExUns: 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b · 25c
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for CSE1L Gene

GeneLoc Exon Structure for
CSE1L
ECgene alternative splicing isoforms for
CSE1L

Expression for CSE1L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CSE1L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CSE1L Gene

This gene is overexpressed in Bone (37.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CSE1L Gene



Protein tissue co-expression partners for CSE1L Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CSE1L Gene:

CSE1L

SOURCE GeneReport for Unigene cluster for CSE1L Gene:

Hs.90073

mRNA Expression by UniProt/SwissProt for CSE1L Gene:

P55060-XPO2_HUMAN
Tissue specificity: Highly expressed in proliferating cells.

Evidence on tissue expression from TISSUES for CSE1L Gene

  • Nervous system(5)
  • Liver(4.5)
  • Stomach(3.3)
  • Skin(3.2)
  • Heart(2.5)
  • Intestine(2.4)
  • Kidney(2.4)
  • Eye(2.1)
genes like me logo Genes that share expression patterns with CSE1L: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CSE1L Gene

Orthologs for CSE1L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CSE1L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CSE1L 34 35
  • 99.9 (n)
oppossum
(Monodelphis domestica)
Mammalia CSE1L 35
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CSE1L 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CSE1L 34 35
  • 94.68 (n)
cow
(Bos Taurus)
Mammalia CSE1L 34 35
  • 93.58 (n)
mouse
(Mus musculus)
Mammalia Cse1l 34 16 35
  • 89.53 (n)
rat
(Rattus norvegicus)
Mammalia Cse1l 34
  • 89.08 (n)
chicken
(Gallus gallus)
Aves CSE1L 34 35
  • 84.17 (n)
lizard
(Anolis carolinensis)
Reptilia CSE1L 35
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cse1l 34
  • 77.1 (n)
Str.7149 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.11576 34
zebrafish
(Danio rerio)
Actinopterygii cse1l 34 34 35
  • 73.7 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5928 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010711 34
  • 55.24 (n)
fruit fly
(Drosophila melanogaster)
Insecta Cas 36 34 35
  • 54.77 (n)
worm
(Caenorhabditis elegans)
Secernentea xpo-2 35
  • 31 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CSE1 34 35 37
  • 49.77 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A00869g 34
  • 48.11 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR273W 34
  • 47.54 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G46520 34
  • 48.12 (n)
rice
(Oryza sativa)
Liliopsida Os01g0235400 34
  • 45.39 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10467 35
  • 62 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes kap109 34
  • 49.39 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU04104 34
  • 44.36 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3837 34
Species where no ortholog for CSE1L was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CSE1L Gene

ENSEMBL:
Gene Tree for CSE1L (if available)
TreeFam:
Gene Tree for CSE1L (if available)

Paralogs for CSE1L Gene

No data available for Paralogs for CSE1L Gene

Variants for CSE1L Gene

Sequence variations from dbSNP and Humsavar for CSE1L Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
VAR_036558 A colorectal cancer sample
rs1000019775 -- 49,059,473(+) GAACT(A/G)GCTAA intron-variant
rs1000073282 -- 49,074,961(+) TCAGC(A/G)GGCTT intron-variant
rs1000092651 -- 49,063,461(+) TGAGG(C/T)GGAAG intron-variant
rs1000122289 -- 49,080,466(+) TAGCA(G/T)TTTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CSE1L Gene

Variant ID Type Subtype PubMed ID
esv2762079 CNV gain 21179565
esv3646009 CNV gain 21293372
nsv1066050 CNV gain 25217958
nsv1067146 CNV loss 25217958

Variation tolerance for CSE1L Gene

Residual Variation Intolerance Score: 2.29% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.92; 48.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CSE1L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CSE1L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSE1L Gene

Disorders for CSE1L Gene

MalaCards: The human disease database

(1) MalaCards diseases for CSE1L Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
colorectal cancer
  • colorectal cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
Search CSE1L in MalaCards View complete list of genes associated with diseases

Relevant External Links for CSE1L

Genetic Association Database (GAD)
CSE1L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CSE1L
genes like me logo Genes that share disorders with CSE1L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CSE1L Gene

Publications for CSE1L Gene

  1. Cloning and characterization of a cellular apoptosis susceptibility gene, the human homologue to the yeast chromosome segregation gene CSE1. (PMID: 7479798) Brinkmann U. … Pastan I. (Proc. Natl. Acad. Sci. U.S.A. 1995) 2 3 4 22 64
  2. Tissue-specific alternative splicing of the CSE1L/CAS (cellular apoptosis susceptibility) gene. (PMID: 10331944) Brinkmann U. … Pastan I. (Genomics 1999) 3 4 22 64
  3. The human CAS (cellular apoptosis susceptibility) gene mapping on chromosome 20q13 is amplified in BT474 breast cancer cells and part of aberrant chromosomes in breast and colon cancer cell lines. (PMID: 8963895) Brinkmann U. … Pastan I. (Genome Res. 1996) 2 3 22 64
  4. Function of CSE1L/CAS in the secretion of HT-29 human colorectal cells and its expression in human colon. (PMID: 19224336) Tsao T.Y. … Jiang M.C. (Mol. Cell. Biochem. 2009) 3 22 64
  5. Dissection of the molecular mechanisms that control the nuclear accumulation of transport factors importin-alpha and CAS in stressed cells. (PMID: 18425415) Kodiha M. … Stochaj U. (Cell. Mol. Life Sci. 2008) 3 22 64

Products for CSE1L Gene

Sources for CSE1L Gene

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