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CSE1L Gene

protein-coding   GIFtS: 63
GCID: GC20P047662

CSE1 Chromosome Segregation 1-Like (Yeast)

(Previous name: chromosome segregation 1 (yeast homolog)-like)
  Search for CSE1L
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CSE1 Chromosome Segregation 1-Like (Yeast)1 2     Cellular Apoptosis Susceptibility1
CAS2 3 5     Chromosome Segregation 1 (Yeast Homolog)-Like1
Cellular Apoptosis Susceptibility Protein2 3     CSE12
Chromosome Segregation 1-Like Protein2 3     exp22
Importin-Alpha Re-Exporter2 3     exportin-22
XPO22 3     Exp23

External Ids:    HGNC: 24311   Entrez Gene: 14342   Ensembl: ENSG000001242077   OMIM: 6013425   UniProtKB: P550603   

Export aliases for CSE1L gene to outside databases

Previous GC identifers: GC20P047391 GC20P048302 GC20P048348 GC20P047096 GC20P044412


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CSE1L Gene:
Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the
importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through
the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha.
Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by
this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the
combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in
cell proliferation. Alternatively spliced transcript variants have been found for this gene. (provided by RefSeq,
Jan 2012)

GeneCards Summary for CSE1L Gene:
CSE1L (CSE1 chromosome segregation 1-like (yeast)) is a protein-coding gene. GO annotations related to this gene include importin-alpha export receptor activity and Ran GTPase binding.

UniProtKB/Swiss-Prot: XPO2_HUMAN, P55060
Function: Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm
after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to
importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the
nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex
into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and
RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to
the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought
to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and
nucleus




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NC_018931.2  NT_011362.11  
Regulatory elements:
   Regulatory transcription factor binding sites in the CSE1L gene promoter:
         Sp1   Pax-6   HNF-4alpha2   E4BP4   Ik-3   FOXL1   Gfi-1   HNF-4alpha1   HFH-1   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): CSE1L promoter sequence
   Search Chromatin IP Primers for CSE1L

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CSE1L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13   Ensembl cytogenetic band:  20q13.13   HGNC cytogenetic band: 20q13

CSE1L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CSE1L gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P047662:  view genomic region     (about GC identifiers)

Start:
47,662,838 bp from pter      End:
47,713,489 bp from pter
Size:
50,652 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: XPO2_HUMAN, P55060 (See protein sequence)
Recommended Name: Exportin-2  
Size: 971 amino acids; 110417 Da
Subunit: Found in a complex with CSE1L/XPO2, Ran and KPNA2. Binds with high affinity to importin-alpha only in the
presence of RanGTP. The complex is dissociated by the combined action of RanBP1 and RanGAP1
Secondary accessions: A3RLL6 B2R5T4 E1P5Y0 F8W904 O75432 Q32M40 Q9H5B7 Q9NTS0 Q9UP98 Q9UP99
Q9UPA0
Alternative splicing: 4 isoforms:  P55060-1   P55060-2   P55060-3   P55060-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CSE1L: NX_P55060

Explore proteomics data for CSE1L at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys165, Lys440, Lys726, Lys824, Lys925, Lys934
  • Modification sites at PhosphoSitePlus

  • See CSE1L Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001243064.1  NP_001307.2  

    ENSEMBL proteins: 
     ENSP00000262982   ENSP00000379495   ENSP00000446477  

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    Novus Biologicals CSE1L Proteins
    Novus Biologicals CSE1L Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for CSE1L 

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    Search eBioscience for ELISAs for CSE1L 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    XPO: Exportins

    5 InterPro protein domains:
     IPR011989 ARM-like
     IPR013713 Cse1
     IPR001494 Importin-beta_N
     IPR005043 CAS_CSE1_C
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry P55060

    ProtoNet protein and cluster: P55060

    2 Blocks protein domains:
    IPB001494 Importin-beta
    IPB005043 CAS/CSE protein C-terminal


    UniProtKB/Swiss-Prot: XPO2_HUMAN, P55060
    Similarity: Belongs to the XPO2/CSE1 family
    Similarity: Contains 1 importin N-terminal domain


    Find genes that share domains with CSE1L           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: XPO2_HUMAN, P55060
    Function: Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm
    after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to
    importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the
    nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex
    into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and
    RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to
    the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought
    to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and
    nucleus

         Genatlas biochemistry entry for CSE1L:
    cellular apoptosis susceptibility gene (CAS),human homolog of the yeast chromosome segregation gene 1
    (CSE1),highly expressed in proliferating tissues,involved in the cell cycle of mammalian cells and in
    apoptosis,transport factor necessary for recycling of importin-alpha from the nucleus to the cytoplasm

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding IPI17719542
    GO:0008262importin-alpha export receptor activity TAS9323134
    GO:0008536Ran GTPase binding IEA--
         
    Find genes that share ontologies with CSE1L           About GenesLikeMe


    Phenotypes:
         7 GenomeRNAi human phenotypes for CSE1L:
     Decreased viability  Decreased viability of wild-ty  Increased cell death in HCT116  Increased circadian period len 
     Synthetic lethal with Ras  Synthetic lethal with gemcitab  Upregulation of Wnt/beta-caten 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cse1l):
     embryogenesis  growth/size/body  mortality/aging 

    Find genes that share phenotypes with CSE1L           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Cse1ltmIpa for CSE1L

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CSE1L
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    miRNA
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    miRTarBase miRNAs that target CSE1L:
    hsa-mir-320a (MIRT044669), hsa-mir-155-5p (MIRT020837), hsa-mir-34a-5p (MIRT047399), hsa-mir-130b-5p (MIRT038321), hsa-mir-137 (MIRT007252)

    Block miRNA regulation of human, mouse, rat CSE1L using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate CSE1L:
    hsa-miR-137 hsa-miR-9* hsa-miR-889
    SwitchGear 3'UTR luciferase reporter plasmidCSE1L 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: CSE1L (NM_001316)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSE1L

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSE1L


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    XPO2_HUMAN, P55060: Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    cytoskeleton1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with CSE1L           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CSE1L About    
    See pathways by source

    SuperPathContained pathways About
    1p53 pathway
    p53 pathway
    2Direct p53 effectors
    Direct p53 effectors
    3Cell cycle Spindle assembly and chromosome separation
    Cell cycle Spindle assembly and chromosome separation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for CSE1L
        Cell cycle Spindle assembly and chromosome separation

    2 BioSystems Pathways for CSE1L
        Direct p53 effectors
    p53 pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CSE1L
    Interactions:

        GeneGlobe Interaction Network for CSE1L

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CSE1L (P550601, 2, 3 ENSP000002629824) via UniProtKB, MINT, STRING, and/or I2D (see all 911)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KPNA2P522922, 3, ENSP000003324554MINT-7945693 MINT-7947479 I2D: score=6 STRING: ENSP00000332455
    RPL22P352682, 3MINT-7945693 MINT-7947479 MINT-63688 I2D: score=5 
    NUP155O756942, 3, ENSP000002314984MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000231498
    PPP5CP530412, 3, ENSP000000124434MINT-63867 I2D: score=5 STRING: ENSP00000012443
    ENSG00000258947Q135092, 3MINT-7945693 I2D: score=2 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006611protein export from nucleus TAS9323134
    GO:0006886intracellular protein transport ----
    GO:0006915apoptotic process TAS7479798
    GO:0008283cell proliferation TAS7479798

    Find genes that share ontologies with CSE1L           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CSE1L (XPO2)

    1 HMDB Compound for CSE1L    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CSE1L gene (3 alternative transcripts): 
    NM_001256135.1  NM_001316.3  NM_177436.1  

    Unigene Cluster for CSE1L:

    CSE1 chromosome segregation 1-like (yeast)
    Hs.90073  [show with all ESTs]
    Unigene Representative Sequence: NM_001316
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000262982(uc002xty.3 uc010zyg.2 uc010ghx.3 uc010ghy.3 uc010zyh.2)
    ENST00000469700 ENST00000396192 ENST00000542325
    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate CSE1L:
    hsa-miR-137 hsa-miR-9* hsa-miR-889
    SwitchGear 3'UTR luciferase reporter plasmidCSE1L 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat CSE1L
      QuantiFast Probe-based Assays in human, mouse, rat CSE1L

    Additional mRNA sequence: 

    AF053641.1 AF053642.1 AK098618.1 AK225610.1 AK297270.1 AK297314.1 AK298477.1 AK299549.1 
    AK300589.1 AK307965.1 AK312306.1 BC108309.1 BC109313.2 BC109314.2 EF426455.1 NR_045796.1 
    U33286.1 

    Selected DOTS entries (see all 36):

    DT.449960  DT.100726211  DT.100846592  DT.100678362  DT.95337904  DT.120805567  DT.120805552  DT.95279266 
    DT.100678360  DT.95279309  DT.100678361  DT.100678368  DT.40133298  DT.95279306  DT.120805573  DT.95279317 
    DT.100678357  DT.120805600  DT.100038098  DT.120805590  DT.86821338  DT.100038099  DT.100678352  DT.100678353 

    Selected AceView cDNA sequences (see all 574):

    CD654468 BE300737 AW029182 BG254914 BG388476 BI860857 AU130354 AA164700 
    BG943589 BU165492 BQ440743 BM473830 BM802705 AA586445 BQ430663 BM453546 
    BM979705 AA459274 AI344110 BM837121 BG389666 CD299959 BQ440139 AF053642 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CSE1L (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
    SP1:                                                                    -                                                                                       
    SP2:                                                                    -                 -                                                                     
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                          -                                                                                                                                 

    ExUns: 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b · 25c
    SP1:                                      -               
    SP2:                                                      
    SP3:                                                      
    SP4:                                                      
    SP5:                                                      


    ECgene alternative splicing isoforms for CSE1L

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CSE1L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATCCTGTAGG
    CSE1L Expression
    About this image


    CSE1L expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Kidney (Urinary System)
             Metanephros
     
     Testis (Reproductive System)
    CSE1L Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CSE1L Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.90073

    UniProtKB/Swiss-Prot: XPO2_HUMAN, P55060
    Tissue specificity: Highly expressed in proliferating cells

        Custom PCR Arrays for CSE1L
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CSE1L gene from Selected species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cse1l1 , 5 chromosome segregation 1-like (S. cerevisiae)1, 5 89.53(n)1
    99.07(a)1
      2 (87.22 cM)5
    1107501  NM_023565.31  NP_076054.11 
     1669060405 
    chicken
    (Gallus gallus)
    Aves CSE1L1 CSE1 chromosome segregation 1-like (yeast) 84.17(n)
    95.47(a)
      419212  XM_417389.4  XP_417389.3 
    lizard
    (Anolis carolinensis)
    Reptilia CSE1L6
    CSE1 chromosome segregation 1-like (yeast)
    94(a)
    1 ↔ 1
    4(146378121-146405806)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.115762 Xenopus laevis transcribed sequence with moderate similarity more 76.19(n)    CA791518.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cse1l2 Danio rerio similar to cellular apoptosis susceptibility more 76.15(n)    BC052479.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cas1 , 3 apoptosis importin-alpha export
    receptor3
    CAS/CSE1 segregation protein1
    51(a)3
    54.77(n)1
    52.86(a)1
      350161  NM_078864.31  NP_523588.21 
    worm
    (Caenorhabditis elegans)
    Secernentea xpo-26
    Protein XPO-2 (xpo-2) mRNA, complete cds
    31(a)
    1 ↔ 1
    I(318542-323352) WBGene00002079
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CSE1(YGL238W)4
    CSE11
    Nuclear envelope protein that mediates the nuclear more4
    CSE11
    49.77(n)1
    39.19(a)1
      7(49552-52434)4
    8526121, 4  NP_011276.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G465201 AT2G46520 48.12(n)
    40.02(a)
      819263  NM_130217.3  NP_182175.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g02354001 Os01g0235400 45.39(n)
    35.35(a)
      4327779  NM_001049057.1  NP_001042522.1 


    ENSEMBL Gene Tree for CSE1L (if available)
    TreeFam Gene Tree for CSE1L (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CSE1L (see all 1278)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0365584
    A colorectal cancer sample4--see VAR_0365582 C F mis40--------
    rs1893060331,2
    --47660783(+) TAAGCA/GGCTAC 3 -- us2k10--------
    rs1923411361,2
    --47660801(+) CTAGTA/GCTGGG 3 -- us2k10--------
    rs1856826541,2
    --47660920(+) TGGAGG/TGCAAT 3 -- us2k10--------
    rs575193991,2
    --47660994(+) TCCCAA/CGTAGC 3 -- us2k10--------
    rs30925181,2
    C,A--47661013(+) cagacC/Gtgcgc 3 -- us2k11Minor allele frequency- G:0.00NA 2
    rs1385155021,2
    --47661160(+) GCCCAG/TCCCTA 3 -- us2k10--------
    rs1896170291,2
    --47661185(+) GAGGCA/GGAGGT 3 -- us2k10--------
    rs761903261,2
    --47661245(+) TCATCC/TCTACA 3 -- us2k11Minor allele frequency- T:0.00NA 2
    rs759320541,2
    --47661246(+) CATCTT/CTACAA 3 -- us2k11Minor allele frequency- C:0.00NA 2

    HapMap Linkage Disequilibrium report for CSE1L (47662838 - 47713489 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CSE1L: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CSE1L
    DNA2.0 Custom Variant and Variant Library Synthesis for CSE1L

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601342    OMIM disorders: --


    Find genes that share disorders with CSE1L           About GenesLikeMe

    7 Novoseek inferred disease relationships for CSE1L gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colon cancer 34.9 6 8963895 (3), 15354419 (2)
    breast cancer 25.7 7 8963895 (4), 12510150 (1)
    hepatocellular carcinoma 15.3 4 11295109 (2), 16786158 (1)
    carcinoma 12.2 2 15354419 (1), 11295109 (1)
    necrosis 6.06 4 8639641 (2), 16786158 (1)
    tumors 4.22 7 11295109 (2), 8639641 (2), 16786158 (1), 12510150 (1)
    cancer 0 7 12510150 (3), 17550137 (1), 15354419 (1), 11724300 (1)

    Genetic Association Database (GAD): CSE1L

    Export disorders for CSE1L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CSE1L gene, integrated from 10 sources (see all 96):
    (articles sorted by number of sources associating them with CSE1L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a cellular apoptosis susceptibility gene, the human homologue to the yeast chromosome segregation gene CSE1. (PubMed id 7479798)1, 2, 3, 9 Brinkmann U.... Pastan I. (Proc. Natl. Acad. Sci. U.S.A. 1995)
    2. The human CAS (cellular apoptosis susceptibility) gene mapping on chromosome 20q13 is amplified in BT474 breast cancer cells and part of aberrant chromosomes in breast and colon cancer cell lines. (PubMed id 8963895)1, 3, 9 Brinkmann U....Pastan I. (Genome Res. 1996)
    3. Tissue-specific alternative splicing of the CSE1L/CAS (cellular apoptosis susceptibility) gene. (PubMed id 10331944)1, 2, 9 Brinkmann U.... Pastan I. (Genomics 1999)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. IRF-1-mediated CAS expression enhances interferon-gamma-induced apoptosis of HT-29 colon adenocarcinoma cells. (PubMed id 11703094)1, 2 Jiang M.C.... Liao C.F. (Mol. Cell Biol. Res. Commun. 2001)
    6. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    7. Determination of the functional domain organization of the importin alpha nuclear import factor. (PubMed id 9786944)1, 2 Herold A.... Cullen B.R. (J. Cell Biol. 1998)
    8. Export of importin-alpha from the nucleus is mediated by a specific nuclear transport factor. (PubMed id 9323134)1, 2 Kutay U.... Goerlich D. (Cell 1997)
    9. High expression of the proliferation and apoptosis associated CSE1L/CAS gene in hepatitis and liver neoplasms: correlation with tumor progression. (PubMed id 11295109)1, 9 Wellmann A....Brinkmann U. (Int. J. Mol. Med. 2001)
    10. Cellular apoptosis susceptibility protein and proliferation in human hepatocellular carcinoma. (PubMed id 16786158)1, 9 Shiraki K....Nakano T. (Int. J. Mol. Med. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1434 HGNC: 2431 AceView: CSE1L Ensembl:ENSG00000124207 euGenes: HUgn1434
    ECgene: CSE1L H-InvDB: CSE1L

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CSE1L Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CSE1L Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CSE1L gene:
    Search GeneIP for patents involving CSE1L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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