CSE1L Gene
protein-coding GIFtS : 63 GCID: GC20 P047662
CSE1 chromosome segregation 1-like (yeast) chromosome segregation 1 (yeast homolog)-like )
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Aliasesfor CSE1L gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases CSE1 Chromosome Segregation 1-Like (Yeast) 1 2 Importin-Alpha Re-Exporter2 3 CAS1 2 3 5 Chromosome Segregation 1 (Yeast Homolog)-Like1 XPO21 2 3 Exp23 CSE11 2 Exportin-21 Cellular Apoptosis Susceptibility Protein2 3 Exp23 Chromosome Segregation 1-Like Protein2 3
Export aliases for CSE1L gene to outside databases Previous GC identifers: GC20P047391 GC20P048302 GC20P048348 GC20P047096 GC20P044412
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Summariesfor CSE1L gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for CSE1L : Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene. (provided by RefSeq, Jan 2012) UniProtKB/Swiss-Prot: XPO2_HUMAN, P55060 Function : Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm afterimport substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus
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Genomic Viewsfor CSE1L gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000020.10 NC_018931.1 NT_011362.10 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the CSE1L gene promoter:Sp1 Pax-6 HNF-4alpha2 E4BP4 Ik-3 FOXL1 Gfi-1 HNF-4alpha1 HFH-1 MRF-2 Other transcription factors Search SABiosciences Chromatin IP Primers for CSE1L Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 20q13 Ensembl cytogenetic band: 20q13.13 HGNC cytogenetic band: 20q13 CSE1L Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 20 GeneLoc Exon Structure
GeneLoc location for GC20P047662: view genomic region
(about GC identifiers )
Start: 47,662,838 bp from pter End:
47,713,489 bp from pter
Size: 50,652 bases Orientation:
plus strand
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Proteinsfor CSE1L gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: XPO2_HUMAN, P55060 See
protein sequence )Recommended Name: Size : 971 amino acids; 110417 DaSubunit : Found in a complex with CSE1L/XPO2, Ran and KPNA2. Binds with high affinity to importin-alpha only in thepresence of RanGTP. The complex is dissociated by the combined action of RanBP1 and RanGAP1
Subcellular location : Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasmSecondary accessions : B2R5T4 E1P5Y0 O75432 Q32M40 Q9H5B7 Q9NTS0 Q9UP98 Q9UP99 Q9UPA0Alternative splicing : 3 isoforms : P55060-1 P55060-2 P55060-3 Explore the universe of human proteins at neXtProt for CSE1L: NX_P55060 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P55060 CSE1L Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins (2 alternative transcripts): NP_001243064.1 NP_001307.2 ENSEMBL proteins: ENSP00000262982 ENSP00000379495 ENSP00000446477 Human Recombinant Protein Products: Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view) : About this table
About GeneDecksing CSE1L Antibody Products: Assay Products for CSE1L:
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Protein
Domains /for CSE1L gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 5 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry P55060 ProtoNet protein and cluster: P55060
2 Blocks protein families : IPB001494 IPB005043 UniProtKB/Swiss-Prot: XPO2_HUMAN, P55060 Similarity : Belongs to the XPO2/CSE1 familySimilarity : Contains 1 importin N-terminal domain
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Functionfor CSE1L gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: XPO2_HUMAN, P55060 Function : Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm afterimport substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus
Genatlas biochemistry entry for CSE1L cellular apoptosis susceptibility gene (CAS),human homolog of the yeast chromosome segregation gene 1 (CSE1),highly expressed in proliferating tissues,involved in the cell cycle of mammalian cells and in apoptosis,transport factor necessary for recycling of importin-alpha from the nucleus to the cytoplasm Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 3 )human mouse rat OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: CSE1L (NM_001316 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CSE1L Vector BioLabs ready-to-use adenovirus/AAV for human , mouse rat CSE1L
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSE1L
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view) : About this table
About GeneDecksing 7 GenomeRNAi human phenotypes for CSE1L :Animal Models: Cse1l tmIpa for CSE1L3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cse1l) :About GeneDecksing
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Pathways & Interactionsfor CSE1L gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways About this table See pathways by source Super-pathway contained gene-specific pathways 1 Cell cycle_Spindle assembly and chromosome separation 2 p53 pathway 3 Direct p53 effectors
Pathway sources See GeneCards unified pathways Show all pathways 1 1 2 About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CSE1L STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/823 Interacting proteins for CSE1L (P55060 1 , 2 , 3 ENSP00000262982 4 via UniProtKB, MINT, STRING , and/or I2D (see all 823 )About this table Gene Ontology (GO): 3 biological process terms (GO ID links to tree view) : About this table
About GeneDecksing
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Drugs & Compoundsfor CSE1L gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for CSE1L 1 HMDB Compound for CSE1L About this table CSE1L / XPO2
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Transcriptsfor CSE1L gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for CSE1L gene (3 alternative transcripts): NM_001256135.1 NM_001316.3 NM_177436.1 Unigene Cluster for CSE1L:
CSE1 chromosome segregation 1-like (yeast) Hs.90073 [show with all ESTs ] Unigene Representative Sequence: NM_001316 5 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000262982 (uc002xty.3 uc010zyg.2 uc010ghx.3 uc010ghy.3 uc010zyh.2 )ENST00000476393 ENST00000469700 ENST00000396192 ENST00000542325 Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 3 )human mouse rat OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: CSE1L (NM_001316 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CSE1L Vector BioLabs ready-to-use adenovirus/AAV for human , mouse rat CSE1L
Additional cDNA sequence: AF053641.1 AF053642.1 AK098618.1 AK225610.1 AK297270.1 AK297314.1 AK298477.1 AK299549.1 AK300589.1 AK307965.1 AK312306.1 BC108309.1 BC109313.2 BC109314.2 EF426455.1 NR_045796.1 U33286.1
24/36 DOTS entries (see all 36 ): DT.449960 DT.100726211
DT.100846592 DT.100678362 DT.95337904 DT.120805567 DT.120805552 DT.95279266 DT.100678360 DT.95279309 DT.100678361 DT.100678368 DT.40133298 DT.95279306 DT.120805573 DT.95279317 DT.100678357 DT.120805600 DT.100038098 DT.120805590 DT.86821338 DT.100038099 DT.100678352 DT.100678353 24/574 AceView cDNA sequences (see all 574 ):
AW472844 BM837121 AI344110 BM453546 AI973168 AF053642 CB140685 AA164700 AI753243 BI858358 BQ430663 BQ221808 BU177239 AU141925 AI826239 CB118931 BG574979 AW303874 BU507290 AA243317 BM473830 CB140990 CB113091 BP373536 GeneLoc Exon Structure 5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CSE1L (see all 6 ) About this scheme ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ SP1 : - SP2 : - - SP3 : SP4 : SP5 : -
ExUns: 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b · 25c SP1 : - SP2 : SP3 : SP4 : SP5 :
ECgene alternative splicing isoforms for CSE1L
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Expression for CSE1L gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section CSE1L expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: ATCCTGTAGG
About this image CSE1L expression in embryonic tissues and stem cells About this table 3 LifeMap In Vivo Development Anatomical Compartments/CellsTissue Category (developmental path) Brain Cerebral Cortex Brain Kidney Metanephros Kidney Neural Tube Telencephalon Neural Tube Expression: Experimental details:
In-situ hybridization
See CSE1L Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for CSE1L SOURCE GeneReport for Unigene cluster: Hs.90073 UniProtKB/Swiss-Prot: XPO2_HUMAN, P55060 Tissue specificity : Highly expressed in proliferating cellsSABiosciences Custom PCR Arrays for CSE1L Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSE1L
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Orthologsfor CSE1L gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for CSE1L gene from 10/36 species (see all 36 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
mouse Mammalia Cse1l1 5
chromosome segregation 1-like (S. cerevisiae)1, 5
89.53(n) 1 99.07(a) 1
2 (87.22 cM) 5 110750 1 NM_023565.3 1 NP_076054.1 1 166906040 5
chicken Aves CSE1L1
CSE1 chromosome segregation 1-like (yeast)
84.17(n) 95.47(a)
419212 XM_417389.3 XP_417389.3
lizard Reptilia CSE1L6
--
94(a)
1 ↔ 1
4(146382277-146402950)
African clawed frog Amphibia Xl.115762
Xenopus laevis transcribed sequence with moderate similarity more
76.19(n)
CA791518.1
zebrafish Actinopterygii cse1l2
Danio rerio similar to cellular apoptosis susceptibility more
76.15(n)
BC052479.1
fruit fly Insecta Cas1 3
apoptosis importin-alpha export receptor3 1
51(a) 3 54.52(n) 1 52.38(a) 1
35016 1 NM_078864.2 1 NP_523588.2 1
worm Secernentea xpo-26
eXPOrtin (nuclear export receptor) family member (... 29(a)
1 ↔ 1
I(318543-323353)
baker's yeast Saccharomycetes CSE1(YGL238W)4 1
Nuclear envelope protein that mediates the nuclear more 4 1
49.14(n) 1 38.2(a) 1
7(49552-52434) 4 852612 1, 4 NP_011276.1 1, 4
thale cress eudicotyledons AT2G465201
exportin-2
48.2(n) 40.34(a)
819263 NM_130217.3 NP_182175.1
rice Liliopsida Os01g02354001
hypothetical protein
45.21(n) 34.46(a)
4327779 NM_001049057.1 NP_001042522.1
ENSEMBL Gene Tree for CSE1L (if available)TreeFam Gene Tree for CSE1L (if available)
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Paralogsfor CSE1L gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section
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Genomic Variantsfor CSE1L gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 20 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for CSE1L (47662838 - 47713489 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for CSE1L: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor CSE1L gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 601342
OMIM disorders : --10 : About MalaCards nevus hepatocellular carcinoma colon cancer colon adenocarcinoma breast cancer colorectal cancer adenocarcinoma carcinoma hepatitis malaria 7 Novoseek disease relationships for CSE1L gene About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
colon cancer
34.9
6
8963895 (3), 15354419 (2)
breast cancer
25.7
7
8963895 (4), 12510150 (1)
hepatocellular carcinoma
15.3
4
11295109 (2), 16786158 (1)
carcinoma
12.2
2
15354419 (1), 11295109 (1)
necrosis
6.06
4
8639641 (2), 16786158 (1)
tumors
4.22
7
11295109 (2), 8639641 (2), 16786158 (1), 12510150 (1)
cancer
0
7
12510150 (3), 17550137 (1), 15354419 (1), 11724300 (1)
Export disorders for CSE1L gene to outside databases
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Publicationsfor CSE1L gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for CSE1L gene, integrated from 9 sources (see all 74 ):(articles sorted by number of sources associating them with CSE1L) Utopia : connect your pdf to the dynamic
Cloning and characterization of a cellular apoptosis susceptibility gene, the human homologue to the yeast chromosome segregation gene CSE1. (PubMed id 7479798) 1 , 2 , 3, 9(1995) The human CAS (cellular apoptosis susceptibility) gene mapping on chromosome 20q13 is amplified in BT474 breast cancer cells and part of aberrant chromosomes in breast and colon cancer cell lines. (PubMed id 8963895) 1 , 3, 9(1996) Tissue-specific alternative splicing of the CSE1L/CAS (cellular apoptosis susceptibility) gene. (PubMed id 10331944) 1 , 2 , 9(1999) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 (2004) The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052) 1 , 2 (2001) Determination of the functional domain organization of the importin alpha nuclear import factor. (PubMed id 9786944) 1 , 2 (1998) Export of importin-alpha from the nucleus is mediated by a specific nuclear transport factor. (PubMed id 9323134) 1 , 2 (1997) High expression of the proliferation and apoptosis associated CSE1L/CAS gene in hepatitis and liver neoplasms: correlation with tumor progression. (PubMed id 11295109) 1 , 9(2001) Cellular apoptosis susceptibility protein and proliferation in human hepatocellular carcinoma. (PubMed id 16786158) 1 , 9(2006) Role of CAS, a human homologue to the yeast chromosome segregation gene CSE1, in toxin and tumor necrosis factor mediated apoptosis. (PubMed id 8639641) 1 , 9(1996)
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About This Section Patent Information for CSE1L gene: CSE1L GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor CSE1L gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for CSE1L OriGene shRNA RFP for CSE1L OriGene 29mer shRNA kits in GFP-retroviral vector in human mouse rat OriGene genome-wide validated SYBR primer pairs in human mouse rat OriGene Protein Over-expression Lysate for CSE1L Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for CSE1L OriGene 3'-UTR Clone for CSE1L OriGene untagged cDNA clones in CMV expression vector in human mouse rat OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for CSE1L OriGene Custom Protein Services for CSE1L OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CSE1L QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSE1L
ThermoFisher Antibody for CSE1L
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse rat CSE1L
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