Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CSDE1 Gene

Aliases for CSDE1 Gene

  • Cold Shock Domain Containing E1, RNA-Binding 2 3
  • D1S155E 3 4 6
  • UNR 3 4 6
  • N-Ras Upstream Gene Protein 3 4
  • Upstream Of NRAS 2 3
  • Cold Shock Domain-Containing Protein E1 3
  • NRAS-Related 3
  • Protein UNR 4
  • KIAA0885 4
  • NRU 4

External Ids for CSDE1 Gene

Previous GeneCards Identifiers for CSDE1 Gene

  • GC01M114972
  • GC01M115049
  • GC01M115259
  • GC01M113117

Summaries for CSDE1 Gene

GeneCards Summary for CSDE1 Gene

CSDE1 (Cold Shock Domain Containing E1, RNA-Binding) is a Protein Coding gene. Among its related pathways are Validated targets of C-MYC transcriptional repression. GO annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot for CSDE1 Gene

  • RNA-binding protein. Required for internal initiation of translation of human rhinovirus RNA. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain.

Gene Wiki entry for CSDE1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSDE1 Gene

Genomics for CSDE1 Gene

Regulatory Elements for CSDE1 Gene

Genomic Location for CSDE1 Gene

Start:
114,716,913 bp from pter
End:
114,758,676 bp from pter
Size:
41,764 bases
Orientation:
Minus strand

Genomic View for CSDE1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CSDE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSDE1 Gene

Proteins for CSDE1 Gene

  • Protein details for CSDE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75534-CSDE1_HUMAN
    Recommended name:
    Cold shock domain-containing protein E1
    Protein Accession:
    O75534
    Secondary Accessions:
    • A8K281
    • E9PGZ0
    • G5E9Q2
    • O94961
    • Q5TF04
    • Q5TF05
    • Q68DF1
    • Q68DI9
    • Q9Y2S4

    Protein attributes for CSDE1 Gene

    Size:
    798 amino acids
    Molecular mass:
    88885 Da
    Quaternary structure:
    • Component of a multi subunit autoregulatory ribonucleoprotein complex (ARC), at least composed of IGF2BP1, PABPC1 and CSDE1. Interacts with STRAP. Part of a complex associated with the FOS mCRD domain and consisting of PABPC1, PAIP1, HNRPD and SYNCRIP. The interaction with PABPC1 is direct and RNA-independent.
    SequenceCaution:
    • Sequence=BAA74908.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAH18231.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CSDE1 Gene

    Alternative splice isoforms for CSDE1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CSDE1 Gene

Proteomics data for CSDE1 Gene at MOPED

Post-translational modifications for CSDE1 Gene

  • Ubiquitination at Lys32, Lys166, Lys207, Lys239, Lys277, Lys295, Lys682, Lys729, and Lys758
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CSDE1 Gene

Domains for CSDE1 Gene

Suggested Antigen Peptide Sequences for CSDE1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75534

UniProtKB/Swiss-Prot:

CSDE1_HUMAN :
  • O75534
Domain:
  • Contains 9 CSD (cold-shock) domains.
genes like me logo Genes that share domains with CSDE1: view

No data available for Gene Families for CSDE1 Gene

Function for CSDE1 Gene

Molecular function for CSDE1 Gene

UniProtKB/Swiss-Prot Function: RNA-binding protein. Required for internal initiation of translation of human rhinovirus RNA. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain.

Gene Ontology (GO) - Molecular Function for CSDE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with CSDE1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CSDE1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CSDE1 Gene

Localization for CSDE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSDE1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CSDE1 Gene COMPARTMENTS Subcellular localization image for CSDE1 gene
Compartment Confidence
cytosol 3
nucleus 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for CSDE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005743 mitochondrial inner membrane IEA --
GO:0005794 Golgi apparatus IDA --
GO:0005886 plasma membrane IDA --
GO:0070937 CRD-mediated mRNA stability complex IDA 15314026
genes like me logo Genes that share ontologies with CSDE1: view

Pathways for CSDE1 Gene

genes like me logo Genes that share pathways with CSDE1: view

Pathways by source for CSDE1 Gene

1 BioSystems pathway for CSDE1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Nitric Oxide Signaling Pathway in human,mouse,rat

Gene Ontology (GO) - Biological Process for CSDE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008584 male gonad development TAS 2204029
GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay IMP 15314026
genes like me logo Genes that share ontologies with CSDE1: view

Compounds for CSDE1 Gene

(1) Novoseek inferred chemical compound relationships for CSDE1 Gene

Compound -log(P) Hits PubMed IDs
adenylate 24.9 2
genes like me logo Genes that share compounds with CSDE1: view

Transcripts for CSDE1 Gene

Unigene Clusters for CSDE1 Gene

Cold shock domain containing E1, RNA-binding:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CSDE1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CSDE1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b · 14c ^ 15 ^ 16 ^
SP1: - -
SP2: - - -
SP3: - - - -
SP4: - - - - - - - -
SP5: - - - - - - - - - -
SP6: - - - - - -
SP7: -
SP8: - - - - - -
SP9: - - - - - - - - -
SP10: - - - -
SP11:
SP12: -
SP13:
SP14: - -
SP15:

ExUns: 17 ^ 18a · 18b ^ 19a · 19b ^ 20 ^ 21a · 21b · 21c ^ 22a · 22b · 22c ^ 23 ^ 24 ^ 25a · 25b · 25c
SP1: - -
SP2: - -
SP3: - -
SP4:
SP5:
SP6:
SP7: - - -
SP8:
SP9:
SP10:
SP11: -
SP12:
SP13:
SP14:
SP15:

Relevant External Links for CSDE1 Gene

GeneLoc Exon Structure for
CSDE1
ECgene alternative splicing isoforms for
CSDE1

Expression for CSDE1 Gene

mRNA expression in normal human tissues for CSDE1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CSDE1 Gene

This gene is overexpressed in Muscle - Skeletal (6.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CSDE1 Gene

SOURCE GeneReport for Unigene cluster for CSDE1 Gene Hs.69855

genes like me logo Genes that share expressions with CSDE1: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CSDE1 Gene

Orthologs for CSDE1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CSDE1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CSDE1 35
  • 99.84 (n)
  • 99.88 (a)
CSDE1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CSDE1 35
  • 96.05 (n)
  • 98.7 (a)
CSDE1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CSDE1 35
  • 96.37 (n)
  • 99.29 (a)
CSDE1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Csde1 35
  • 94.57 (n)
  • 98.5 (a)
Csde1 16
Csde1 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CSDE1 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CSDE1 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100364335 35
  • 94.44 (n)
  • 98.62 (a)
chicken
(Gallus gallus)
Aves CSDE1 35
  • 85.43 (n)
  • 92.44 (a)
CSDE1 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CSDE1 36
  • 92 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.4677 35
tropical clawed frog
(Silurana tropicalis)
Amphibia csde1 35
  • 76.98 (n)
  • 86 (a)
Str.5856 35
zebrafish
(Danio rerio)
Actinopterygii csde1 35
  • 71.57 (n)
  • 78.62 (a)
csde1 36
  • 75 (a)
OneToMany
csde1 36
  • 75 (a)
OneToMany
CU571336.1 36
  • 6 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004937 35
  • 52.5 (n)
  • 48.7 (a)
fruit fly
(Drosophila melanogaster)
Insecta Unr 35
  • 53.2 (n)
  • 50.7 (a)
Unr 36
  • 35 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8024 36
  • 40 (a)
OneToOne
Species with no ortholog for CSDE1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CSDE1 Gene

ENSEMBL:
Gene Tree for CSDE1 (if available)
TreeFam:
Gene Tree for CSDE1 (if available)

Paralogs for CSDE1 Gene

Selected SIMAP similar genes for CSDE1 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with CSDE1: view

No data available for Paralogs for CSDE1 Gene

Variants for CSDE1 Gene

Sequence variations from dbSNP and Humsavar for CSDE1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs13990 -- 114,723,938(-) CTGAG(A/G)AGTGT synonymous-codon, reference
rs743042 -- 114,728,274(-) CCTGA(A/G)TTCAC intron-variant
rs975718 -- 114,725,552(-) aactt(C/T)ttggt intron-variant
rs1985866 -- 114,729,259(-) tagcc(C/G)ggcat intron-variant
rs1985867 -- 114,729,250(-) atagt(A/G/T)gtggg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CSDE1 Gene

Variant ID Type Subtype PubMed ID
esv28734 CNV Loss 19812545

Relevant External Links for CSDE1 Gene

HapMap Linkage Disequilibrium report
CSDE1
Human Gene Mutation Database (HGMD)
CSDE1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSDE1 Gene

Disorders for CSDE1 Gene

(1) Novoseek inferred disease relationships for CSDE1 Gene

Disease -log(P) Hits PubMed IDs
shock 18.8 4

Relevant External Links for CSDE1

Genetic Association Database (GAD)
CSDE1
Human Genome Epidemiology (HuGE) Navigator
CSDE1
genes like me logo Genes that share disorders with CSDE1: view

No data available for UniProtKB/Swiss-Prot for CSDE1 Gene

Publications for CSDE1 Gene

  1. Characterization of unr; a gene closely linked to N-ras. (PMID: 2204029) Jeffers M. … Pellicer A. (Nucleic Acids Res. 1990) 2 3 23
  2. Exon skipping in the expression of the gene immediately upstream of N-ras (unr/NRU). (PMID: 8439573) Boussadia O. … Dautry F. (Biochim. Biophys. Acta 1993) 3 4 23
  3. unr, a cellular cytoplasmic RNA-binding protein with five cold-shock domains, is required for internal initiation of translation of human rhinovirus RNA. (PMID: 10049359) Hunt S.L. … Jackson R.J. (Genes Dev. 1999) 3 4 23
  4. A mechanism for translationally coupled mRNA turnover: interaction between the poly(A) tail and a c-fos RNA coding determinant via a protein complex. (PMID: 11051545) Grosset C. … Shyu A.-B. (Cell 2000) 3 4 23
  5. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4

Products for CSDE1 Gene

Sources for CSDE1 Gene

Back to Top

Content