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CSDE1 Gene

protein-coding   GIFtS: 56
GCID: GC01M115259

Cold Shock Domain Containing E1, RNA-Binding

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cold Shock Domain Containing E1, RNA-Binding1 2     NRAS-related2
D1S155E2 3 5     Cold Shock Domain-Containing Protein E12
UNR2 3 5     KIAA08853
Upstream Of NRAS1 2     NRU3
N-Ras Upstream Gene Protein2 3     Protein UNR3

External Ids:    HGNC: 299051   Entrez Gene: 78122   Ensembl: ENSG000000093077   OMIM: 1915105   UniProtKB: O755343   

Export aliases for CSDE1 gene to outside databases

Previous GC identifers: GC01M114972 GC01M115049 GC01M113117


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CSDE1 Gene:
CSDE1 (cold shock domain containing E1, RNA-binding) is a protein-coding gene. GO annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot: CSDE1_HUMAN, O75534
Function: RNA-binding protein. Required for internal initiation of translation of human rhinovirus RNA. May be
involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic
deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant
of instability (mCRD) domain

Gene Wiki entry for CSDE1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the CSDE1 gene promoter:
         FOXC1   NRSF form 1   NRSF form 2   Pax-4a   Gfi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCSDE1 promoter sequence
   Search Chromatin IP Primers for CSDE1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CSDE1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p22   Ensembl cytogenetic band:  1p13.2   HGNC cytogenetic band: 1p13.2

CSDE1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CSDE1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M115259:  view genomic region     (about GC identifiers)

Start:
115,259,534 bp from pter      End:
115,301,297 bp from pter
Size:
41,764 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CSDE1_HUMAN, O75534 (See protein sequence)
Recommended Name: Cold shock domain-containing protein E1  
Size: 798 amino acids; 88885 Da
Subunit: Component of a multi subunit autoregulatory ribonucleoprotein complex (ARC), at least composed of
IGF2BP1, PABPC1 and CSDE1. Interacts with STRAP. Part of a complex associated with the FOS mCRD domain and
consisting of PABPC1, PAIP1, HNRPD and SYNCRIP. The interaction with PABPC1 is direct and RNA-independent
Sequence caution: Sequence=BAA74908.2; Type=Erroneous initiation; Sequence=CAH18231.1; Type=Erroneous initiation;
5 PDB 3D structures from and Proteopedia for CSDE1:
1WFQ (3D)        1X65 (3D)        2YTV (3D)        2YTX (3D)        2YTY (3D)    
Secondary accessions: A8K281 E9PGZ0 O94961 Q5TF04 Q5TF05 Q68DF1 Q68DI9 Q9Y2S4
Alternative splicing: 3 isoforms:  O75534-1   O75534-2   O75534-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CSDE1: NX_O75534

Explore proteomics data for CSDE1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys32, Lys166, Lys207, Lys239, Lys277, Lys295, Lys682, Lys729, Lys758
  • Modification sites at PhosphoSitePlus

  • See CSDE1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001007554.1  NP_001123995.1  NP_001229820.1  NP_001229821.1  NP_001229822.1  NP_009089.4  

    ENSEMBL proteins: 
     ENSP00000342408   ENSP00000407724   ENSP00000351329   ENSP00000261443   ENSP00000431297  
     ENSP00000358543   ENSP00000432958   ENSP00000437159   ENSP00000431770   ENSP00000435185  
     ENSP00000431562   ENSP00000432805  

    CSDE1 Human Recombinant Protein Products:

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    Novus Biologicals CSDE1 Proteins
    Novus Biologicals CSDE1 Lysates
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CSDE1

     
    Search eBioscience for Proteins for CSDE1 

    CSDE1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    LSBio Antibodies in human, mouse, rat for CSDE1

    CSDE1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for CSDE1
    Cloud-Clone Corp. CLIAs for CSDE1
    Search eBioscience for ELISAs for CSDE1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR024642 SUZ-C
     IPR019844 Cold-shock_CS
     IPR012340 NA-bd_OB-fold
     IPR011129 Cold_shock_prot
     IPR002059 CSP_DNA-bd

    Graphical View of Domain Structure for InterPro Entry O75534

    ProtoNet protein and cluster: O75534

    2 Blocks protein domains:
    IPB002059 Cold-shock DNA-binding domain
    IPB011129 Cold shock protein


    UniProtKB/Swiss-Prot: CSDE1_HUMAN, O75534
    Similarity: Contains 9 CSD (cold-shock) domains


    Find genes that share domains with CSDE1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CSDE1_HUMAN, O75534
    Function: RNA-binding protein. Required for internal initiation of translation of human rhinovirus RNA. May be
    involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic
    deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant
    of instability (mCRD) domain

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003723RNA binding ----
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with CSDE1           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CSDE1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CSDE1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CSDE1

    miRNA
    Products:
        
    miRTarBase miRNAs that target CSDE1:
    hsa-mir-423-5p (MIRT038124), hsa-mir-1229-3p (MIRT036276), hsa-mir-23b-3p (MIRT046338), hsa-mir-23a-3p (MIRT050445), hsa-mir-92a-3p (MIRT049113), hsa-mir-326 (MIRT043630), hsa-mir-340-5p (MIRT019618), hsa-mir-92b-3p (MIRT040695), hsa-mir-204-5p (MIRT047025), hsa-mir-16-5p (MIRT031909), hsa-mir-1226-3p (MIRT036423), hsa-mir-30c-5p (MIRT047849), hsa-mir-320a (MIRT044417)

    Block miRNA regulation of human, mouse, rat CSDE1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CSDE1 (see all 41):
    hsa-miR-582-3p hsa-miR-15a hsa-miR-519a hsa-miR-218 hsa-miR-502-3p hsa-miR-424 hsa-miR-124 hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmidCSDE1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CSDE1
    Predesigned siRNA for gene silencing in human, mouse, rat CSDE1

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for CSDE1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): CSDE1 (NM_001130523)
    Sino Biological Human cDNA Clone for CSDE1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CSDE1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSDE1

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for CSDE1
    Browse ESI BIO Cell Lines and PureStem Progenitors for CSDE1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSDE1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CSDE1_HUMAN, O75534: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus3
    cytoskeleton1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005743mitochondrial inner membrane ----
    GO:0005794Golgi apparatus IDA--
    GO:0005886plasma membrane IDA--
    GO:0070937CRD-mediated mRNA stability complex IDA15314026

    Find genes that share ontologies with CSDE1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CSDE1 About    
    See pathways by source

    SuperPathContained pathways About
    1Validated targets of C-MYC transcriptional repression
    Validated targets of C-MYC transcriptional repression


    1 BioSystems Pathway for CSDE1
        Validated targets of C-MYC transcriptional repression



        Pathway & Disease-focused RT2 Profiler PCR Array including CSDE1: 
              Nitric Oxide Signaling Pathway in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CSDE1

    Selected Interacting proteins for CSDE1 (O755343) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STT3AP469773I2D: score=4 
    LOH12CR1Q969J33I2D: score=3 
    WNK1Q9H4A33I2D: score=3 
    CDC42P609533I2D: score=2 
    DENRO435833I2D: score=2 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0008584male gonad development TAS2204029
    GO:0070966nuclear-transcribed mRNA catabolic process, no-go decay IMP15314026

    Find genes that share ontologies with CSDE1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CSDE1

    1 Novoseek inferred chemical compound relationship for CSDE1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenylate 24.9 3 15314026 (2)



    Find genes that share compounds with CSDE1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CSDE1 gene (6 alternative transcripts): 
    NM_001007553.2  NM_001130523.2  NM_001242891.1  NM_001242892.1  NM_001242893.1  NM_007158.5  

    Unigene Cluster for CSDE1:

    Cold shock domain containing E1, RNA-binding
    Hs.69855  [show with all ESTs]
    Unigene Representative Sequence: NM_001242891
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000339438(uc001efj.3 uc001efl.3 uc001efn.3) ENST00000438362(uc001efi.3 uc001efm.3)
    ENST00000358528(uc001efk.3 uc009wgv.3) ENST00000261443 ENST00000530886
    ENST00000369530 ENST00000483407 ENST00000534699 ENST00000483030 ENST00000530784
    ENST00000529046 ENST00000525132 ENST00000534389 ENST00000525878 ENST00000525970
    ENST00000533818 ENST00000524652
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CSDE1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CSDE1 (see all 41):
    hsa-miR-582-3p hsa-miR-15a hsa-miR-519a hsa-miR-218 hsa-miR-502-3p hsa-miR-424 hsa-miR-124 hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmidCSDE1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CSDE1
    Predesigned siRNA for gene silencing in human, mouse, rat CSDE1
    Clone
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    OriGene clones in human, mouse for CSDE1 (see all 17)
    OriGene ORF clones in mouse, rat for CSDE1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): CSDE1 (NM_001130523)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CSDE1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSDE1
    Primer
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    OriGene qPCR primer pairs and template standards for CSDE1
    OriGene qSTAR qPCR primer pairs in human, mouse for CSDE1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CSDE1
      QuantiTect SYBR Green Assays in human, mouse, rat CSDE1
      QuantiFast Probe-based Assays in human, mouse, rat CSDE1

    Additional mRNA sequence: 

    AB020692.1 AF070542.1 AF077054.1 AK022516.1 AK022528.1 AK130392.1 AK290146.1 AL050150.1 
    AL110192.1 AY049788.1 BC017662.1 BC021692.1 BC032446.1 BX648561.1 BX648780.1 CR749378.1 
    CR749431.1 

    Selected DOTS entries (see all 69):

    DT.92474308  DT.100693473  DT.100766644  DT.92474348  DT.92378501  DT.92474344  DT.95101494  DT.100693459 
    DT.121460021  DT.97818910  DT.100693465  DT.95124940  DT.121460068  DT.121459963  DT.121460114  DT.100041872 
    DT.95200028  DT.100693483  DT.102839209  DT.100855923  DT.121460122  DT.100693460  DT.100693485  DT.121459921 

    Selected AceView cDNA sequences (see all 1776):

    AI823818 AI718920 AA429708 BP358982 BE889512 BE615767 BP359705 BM663111 
    BQ430766 AI753417 BU160086 BQ212883 AI872119 BP343792 BM794840 BU178370 
    BQ718672 R90945 AA330511 AW510497 AW303942 AY049788 BF982557 BQ945981 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CSDE1 (see all 15)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b · 14c ^ 15 ^ 16 ^
    SP1:                                                  -     -                                                                                                   
    SP2:                                                  -                                   -     -                                                               
    SP3:                                                  -     -                             -     -                                                               
    SP4:              -     -           -     -           -     -                             -     -                                                               
    SP5:              -     -     -     -     -     -     -     -                             -     -                                                               

    ExUns: 17 ^ 18a · 18b ^ 19a · 19b ^ 20 ^ 21a · 21b · 21c ^ 22a · 22b · 22c ^ 23 ^ 24 ^ 25a · 25b · 25c
    SP1:                                      -                             -                                 
    SP2:                                      -                             -                                 
    SP3:                                      -                             -                                 
    SP4:                                                                                                      
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for CSDE1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CSDE1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAAATGAGGA
    CSDE1 Expression
    About this image


    CSDE1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Ovary (Reproductive System)
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Brain (Nervous System)
             Cerebral Cortex
    CSDE1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CSDE1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.69855
        Pathway & Disease-focused RT2 Profiler PCR Array including CSDE1: 
              Nitric Oxide Signaling Pathway in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CSDE1
    OriGene qSTAR qPCR primer pairs in human, mouse for CSDE1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CSDE1
    QuantiTect SYBR Green Assays in human, mouse, rat CSDE1
    QuantiFast Probe-based Assays in human, mouse, rat CSDE1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSDE1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CSDE1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Csde11 , 5 cold shock domain containing E1, RNA binding1, 5 94.57(n)1
    98.5(a)1
      3 (45.25 cM)5
    2296631  NM_144901.31  NP_659150.11 
     1030205465 
    chicken
    (Gallus gallus)
    Aves CSDE11 cold shock domain containing E1, RNA-binding 85.43(n)
    92.44(a)
      419886  NM_001030918.1  NP_001026089.1 
    lizard
    (Anolis carolinensis)
    Reptilia CSDE16
    cold shock domain containing E1, RNA-binding
    92(a)
    1 ↔ 1
    4(130396386-130423038)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.46772 Xenopus laevis clone S10-34-A4 mRNA sequence 75.25(n)    AF549970.1 
    zebrafish
    (Danio rerio)
    Actinopterygii csde11 cold shock domain containing E1, RNA-binding 71.57(n)
    78.62(a)
      337096  XM_005166957.1  XP_005167014.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Unr1 Upstream of N-ras 53.2(n)
    50.7(a)
      38963  NM_001144440.2  NP_001137912.1 


    ENSEMBL Gene Tree for CSDE1 (if available)
    TreeFam Gene Tree for CSDE1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CSDE1 gene
    3 SIMAP similar genes for CSDE1 using alignment to 8 protein entries:     CSDE1_HUMAN (see all proteins):
    DKFZp586J0620    DKFZp566C233    UNR

    Find genes that share paralogs with CSDE1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CSDE1 (see all 822)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1493908151,2
    --115261668(+) TAGCTA/GACACC 6 -- int10--------
    rs772548241,2
    F--115261750(+) CAAAAC/GAGTGG 6 -- int11Minor allele frequency- G:0.05WA 118
    rs1463957801,2
    --115261799(+) GTGGCA/GCATGC 6 -- int10--------
    rs1850171741,2
    C--115261833(+) GCTGAC/TGTGGG 6 -- int10--------
    rs1891393751,2
    --115261858(+) CCAGGG/TGGTTG 6 -- int10--------
    rs1397525771,2
    --115261898(+) GTAACC/TGAATC 6 -- int10--------
    rs1432144281,2
    --115262076(+) AAGTAG/TGAAGT 6 -- int10--------
    rs120668181,2
    C,H--115262122(+) GAAAAG/ATGATG 6 -- int14Minor allele frequency- A:0.00NS EA 410
    rs726878761,2
    C,F--115262124(+) AAAGTG/AATGTG 6 -- int16Minor allele frequency- A:0.12WA NA CSA EA 364
    rs1123883421,2
    C--115262190(+) AACAAC/AAAAAC 6 -- int11Minor allele frequency- A:0.50CSA 2

    HapMap Linkage Disequilibrium report for CSDE1 (115259534 - 115301297 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CSDE1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv28734CNV Loss19812545

    Human Gene Mutation Database (HGMD): CSDE1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CSDE1
    DNA2.0 Custom Variant and Variant Library Synthesis for CSDE1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 191510    OMIM disorders: --


    Find genes that share disorders with CSDE1           About GenesLikeMe

    1 Novoseek inferred disease relationship for CSDE1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 18.8 5 7518919 (2), 8934551 (1), 10101203 (1)

    Genetic Association Database (GAD): CSDE1
    Human Genome Epidemiology (HuGE) Navigator: CSDE1 (6 documents)

    Export disorders for CSDE1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CSDE1 gene, integrated from 10 sources (see all 73):
    (articles sorted by number of sources associating them with CSDE1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1998)
    2. Characterization of unr; a gene closely linked to N-ras. (PubMed id 2204029)1, 3, 9 Jeffers M....Pellicer A. (Nucleic Acids Res. 1990)
    3. UNR, a new partner of poly(A)-binding protein, plays a key role in translationally coupled mRNA turnover mediated by the c-fos major coding-region determinant. (PubMed id 15314026)1, 2, 9 Chang T.-C.... Shyu A.-B. (Genes Dev. 2004)
    4. Exon skipping in the expression of the gene immediately upstream of N-ras (unr/NRU). (PubMed id 8439573)1, 2, 9 Boussadia O.... Dautry F. (Biochim. Biophys. Acta 1993)
    5. unr, a cellular cytoplasmic RNA-binding protein with five cold-shock domains, is required for internal initiation of translation of human rhinovirus RNA. (PubMed id 10049359)1, 2, 9 Hunt S.L.... Jackson R.J. (Genes Dev. 1999)
    6. A mechanism for translationally coupled mRNA turnover: interaction between the poly(A) tail and a c-fos RNA coding determinant via a protein complex. (PubMed id 11051545)1, 2, 9 Grosset C....Shyu A.-B. (Cell 2000)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    8. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    9. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    10. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7812 HGNC: 29905 AceView: NRASandUNR Ensembl:ENSG00000009307 euGenes: HUgn7812
    ECgene: CSDE1 H-InvDB: CSDE1

    (According to HUGE)
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    HUGE: KIAA0885

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CSDE1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CSDE1 gene:
    Search GeneIP for patents involving CSDE1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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