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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CSDA Gene

protein-coding GIFtS: 59
GCID: GC12M010851

cold shock domain protein A

Explore 12 diseases affiliated with
CSDA via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cold Shock Domain Protein A¹ ²		DbpA¹
DBPA² ³ ⁵		Cold-Shock Domain Containing A1²
CSDA1¹ ²		Cold-Shock Domain Protein A²
ZONAB¹ ²		DNA-Binding Protein A²
Cold Shock Domain-Containing Protein A² ³		ZO-1-Associated Nucleic Acid-Binding Protein²
Single-Strand DNA-Binding Protein NF-GMB² ³

External Ids:	HGNC: 2428¹	Entrez Gene: 8531²	Ensembl: ENSG00000060138⁷	OMIM: 603437⁵	UniProtKB: P16989³

Export aliases for CSDA gene to outside databases

Previous GC identifers: GC12M010555 GC12M010995 GC12M010751 GC12M010742

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: DBPA_HUMAN, P16989

Function: Binds to the GM-CSF promoter. Seems to act as a repressor. Binds also to full length mRNA and to short RNA

sequences containing the consensus site 5'-UCCAUCA-3'. May have a role in translation repression (By similarity)

Gene Wiki entry for CSDA

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_009714.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CSDA gene promoter:
Ik-3 NF-AT Meis-1b NF-AT4 NF-AT2 NF-AT3 ARP-1 Meis-1a Meis-1 NF-AT1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CSDA promoter sequence

Search SABiosciences Chromatin IP Primers for CSDA

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CSDA

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.1 Ensembl cytogenetic band: 12p13.2 HGNC cytogenetic band: 12p13.1

CSDA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CSDA gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M010851: view genomic region (about GC identifiers)

Start:	10,851,676 bp from pter	End:	10,875,953 bp from pter
Size:	24,278 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DBPA_HUMAN, P16989 (See protein sequence)

Recommended Name: DNA-binding protein A

Size: 372 amino acids; 40090 Da

Subunit: Found in a mRNP complex with YBX2 (By similarity)

Subcellular location: Cytoplasm. Nucleus

Sequence caution: Sequence=AAA35749.1; Type=Erroneous initiation;

Secondary accessions: B2RBW6 Q14121 Q969N6 Q96B76

Alternative splicing: 3 isoforms: P16989-1 P16989-2 P16989-3

Explore the universe of human proteins at neXtProt for CSDA: NX_P16989

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P16989

CSDA Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001138898.1 NP_003642.3

ENSEMBL proteins:

ENSP00000279550 ENSP00000228251 ENSP00000441447

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: CSDA Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for CSDA
	GenScript Custom Purified and Recombinant Proteins Services for CSDA
	Novus Biologicals CSDA Protein Novus Biologicals CSDA Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CSDA

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	ISS	--
GO:0005737	cytoplasm	IDA	--
GO:0005844	polysome	IEA	--
GO:0005921	gap junction	--	--
GO:0005923	tight junction	ISS	--

CSDA for ontologies About GeneDecksing

CSDA Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of CSDA
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	Browse OriGene Antibodies OriGene Custom Antibody Services for CSDA
	GenScript Custom Superior Antibodies Services for CSDA
	Novus Biologicals CSDA Antibodies
	Search for Antibodies for CSDA at Abcam
	Uscn Antibodies for CSDA
	ThermoFisher Antibodies for CSDA

Assay Products for CSDA:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CSDA
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CSDA

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CSDA for domains About GeneDecksing

4 InterPro domains/families:

IPR019844 Cold-shock_CS

IPR012340 NA-bd_OB-fold

IPR011129 Cold_shock_prot

IPR002059 CSP_DNA-bd

Graphical View of Domain Structure for InterPro Entry P16989

ProtoNet protein and cluster: P16989

2 Blocks protein families:

IPB002059 Cold-shock DNA-binding domain

IPB011129 Cold shock protein

UniProtKB/Swiss-Prot: DBPA_HUMAN, P16989

Similarity: Contains 1 CSD (cold-shock) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: DBPA_HUMAN, P16989

Function: Binds to the GM-CSF promoter. Seems to act as a repressor. Binds also to full length mRNA and to short RNA

sequences containing the consensus site 5'-UCCAUCA-3'. May have a role in translation repression (By similarity)

Genatlas biochemistry entry for CSDA:

cold shock domain protein A

miRNA Products:		OriGene 3'-UTR Clone (see all 2): CSDA Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CSDA
		8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate CSDA (see all 26):
		hsa-miR-1226 hsa-miR-137 hsa-miR-29a hsa-miR-29c hsa-miR-9 hsa-miR-205* hsa-miR-3915 hsa-miR-3662

		SwitchGear 3'UTR luciferase reporter plasmid: CSDA 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CSDA (see all 7) OriGene shRNA RFP: CSDA OriGene siRNA: CSDA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CSDA

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CSDA

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CSDA (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CSDA (see all 4) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): CSDA (NM_003651)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CSDA
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSDA

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CSDA
		Search LifeMap BioReagents cell lines for CSDA

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSDA

Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	--	--
GO:0003690	double-stranded DNA binding	TAS	2977358
GO:0003697	single-stranded DNA binding	--	--
GO:0003700	sequence-specific DNA binding transcription factor activity	NAS	8710501
GO:0003714	transcription corepressor activity	TAS	8710501

CSDA for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Csda^tm1Ley for CSDA
     6 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Csda):

embryogenesis	endocrine/exocrine gland	growth/size	mortality/aging	nervous system
reproductive system

CSDA for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cell adhesion Tight junctions

Cell adhesion Tight junctions

1.00

Cell adhesion_Tight junctions

0.99

Sertoli-Sertoli Cell Junction Dynamics

Sertoli-Sertoli Cell Junction Dynamics

1.00

Epithelial Tight Junctions

0.36

RalA downstream regulated genes

RalA downstream regulated genes

1.00

Tight junction

Tight junction

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for CSDA

Cell adhesion Tight junctions

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CSDA

	Sertoli-Sertoli Cell Junction Dynamics
	Epithelial Tight Junctions

1 GeneGo (Thomson Reuters) Pathway for CSDA

Cell adhesion Tight junctions

1 BioSystems Pathway for CSDA

RalA downstream regulated genes

1 Kegg Pathway (Kegg details for CSDA):

Tight junction

CSDA for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CSDA

STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

5/621 Interacting proteins for CSDA (P16989^{2, 3} ENSP00000228251⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 621)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GSK3B	P49841²^,³, ENSP00000324806⁴	MINT-65985 MINT-65984 I2D: score=3 STRING: ENSP00000324806
MAPK1	P28482²^,³, ENSP00000215832⁴	MINT-65981 MINT-65988 I2D: score=3 STRING: ENSP00000215832
SRRM1	Q8IYB3²^,³, ENSP00000326261⁴	MINT-7945693 I2D: score=1 STRING: ENSP00000326261
MAP3K14	Q99558²^,³	MINT-48864 I2D: score=2
NSF	P46459²^,³	MINT-7945693 I2D: score=1

About this table

Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	TAS	8710501
GO:0001701	in utero embryonic development	IEA	--
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	--	--
GO:0007283	spermatogenesis	--	--

CSDA for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CSDA for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CSDA
4 Novoseek chemical compound relationships for CSDA gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
dbpa	99	199	16243807 (9), 19749785 (9), 7628487 (8), 7651426 (8) (see all 41)
hydrogen	26.5	4	10716181 (2), 15162492 (1), 11262979 (1)
lysine	5.42	4	10473582 (3)
vegf	0	4	16198352 (2), 12433987 (2)

Search CenterWatch for drugs/clinical trials and news about CSDA / DBPA

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CSDA gene (2 alternative transcripts):

NM_001145426.1 NM_003651.4

Unigene Cluster for CSDA:

Cold shock domain protein A

Hs.221889 [show with all ESTs]

Unigene Representative Sequence: NM_003651

18 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000279550(uc001qyu.3) ENST00000228251(uc001qyt.3) ENST00000540447

ENST00000540975 ENST00000546164 ENST00000536823 ENST00000366286 ENST00000542002

ENST00000366290 ENST00000542641 ENST00000541351 ENST00000544504 ENST00000539204

ENST00000544622 ENST00000546298 ENST00000544501 ENST00000536107 ENST00000540747

miRNA Products:		OriGene 3'-UTR Clone (see all 2): CSDA Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CSDA
		8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate CSDA (see all 26):
		hsa-miR-1226 hsa-miR-137 hsa-miR-29a hsa-miR-29c hsa-miR-9 hsa-miR-205* hsa-miR-3915 hsa-miR-3662

		SwitchGear 3'UTR luciferase reporter plasmid: CSDA 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CSDA (see all 7) OriGene shRNA RFP: CSDA OriGene siRNA: CSDA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CSDA

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CSDA (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CSDA (see all 4) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): CSDA (NM_003651)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CSDA
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSDA

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CSDA Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CSDA
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CSDA
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CSDA

Additional cDNA sequence:

AK314846.1 BC008801.2 BC009744.2 BC015564.1 BC015913.1 BC021926.1 BC150580.1 M24069.1

X72712.1 X95325.1

24/37 DOTS entries (see all 37):

DT.319993 DT.97864614 DT.100882846 DT.100882850 DT.97864619 DT.97864621 DT.40129259 DT.91660185

DT.100882853 DT.121173921 DT.95191600 DT.100882854 DT.95123479 DT.121173945 DT.319996 DT.95105476

DT.97767540 DT.97864618 DT.100727984 DT.121173905 DT.100882852 DT.121173924 DT.40306924 DT.95191544

24/784 AceView cDNA sequences (see all 784):

BX492064 CA453944 AU185835 BE905964 BM697141 AI056564 AW516437 BF970950

BM661778 CD723364 AA151251 CB146760 CD677842 AI763104 CB120222 T39284

BG941524 BQ129197 N35942 AI583206 BM714179 BF590681 AA960783 AI379686

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for CSDA (see all 12) About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5a	·	5b	^	6a	·	6b	·	6c	^	7a	·	7b	^	8	^	9	^	10a	·	10b	^	11a	·	11b	·	11c	^	12a	·	12b	^	13	^	14a	·	14b	·	14c
SP1:					-		-						-		-								-		-								-		-		-		-
SP2:					-		-						-		-								-		-		-						-		-		-		-
SP3:																							-		-		-						-		-		-		-
SP4:																																					-		-
SP5:																															-		-		-		-		-

ECgene alternative splicing isoforms for CSDA

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CSDA expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATTTAAAAAA

About this image

CSDA expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Outer Nuclear Layer

Mature Rod Cells

Photoreceptors, Retina

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CSDA Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CSDA

SOURCE GeneReport for Unigene cluster: Hs.221889

UniProtKB/Swiss-Prot: DBPA_HUMAN, P16989

Tissue specificity: Highly expressed in skeletal muscle and heart

SABiosciences Expression via Pathway-Focused PCR Array including CSDA:

Tight Junctions in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CSDA Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CSDA
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CSDA
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CSDA

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSDA

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for CSDA gene from 5/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Csda^{1 , 5}	cold shock domain protein A^{1, 5}	88.64(n)¹ 89.2(a)¹		6 (63.44 cM)⁵ 56449¹ NM_139117.2¹ NP_620817.2¹ 131364858⁵
chicken (Gallus gallus)	Aves	-- --	Uncharacterized protein	73(a) 63(a)	1 ↔ 1 possible ortholog	1(81463346-81503703) 1(81520590-81521384)
African clawed frog (Xenopus laevis)	Amphibia	M80257.1²	--	81.99(n)		M80257.1
fruit fly (Drosophila melanogaster)	Insecta	yps⁶	ypsilon schachtel	28(a)	possible ortholog	3L(12114374-12118250)
worm (Caenorhabditis elegans)	Secernentea	cey-1⁶ cey-2⁶ (see all 4)	Y-box family member (cey-2) (see all 4)	42(a) 30(a) (see all 4)	many ↔ many many ↔ many (see all 4)	II(11039391-11041150) I(5619570-5620671)

ENSEMBL Gene Tree for CSDA (if available)
TreeFam Gene Tree for CSDA (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CSDA gene

YBX2² YBX1²

2 SIMAP similar genes for CSDA using alignment to 2 protein entries: DBPA_HUMAN (see all proteins):

YBX1 YBX2

CSDA for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for CSDA
PGOHUM00000248811

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs12310601^1,2	C,F,H,	--	10851178(+)	`CACAAA/GCCTAC`	2	--	int¹		14		NS EA NA CSA WA	919
rs4445727^1,2	C,F,A,H,	--	10851226(+)	`CTATAC/TGGCAC`	2	--	int¹		14		NS EA NA CSA WA	909
rs73044637^1,2	C,	--	10851303(+)	`AAAGAG/ACTCCC`	2	--	int¹		5		NA CSA WA EA	361
rs145368486^1,2		--	10851405(+)	`GTCATC/TACGTC`	2	--	int¹		0	--	--	--	--
rs117292144^1,2		--	10851407(+)	`CATCAC/TGTCAC`	2	--	int¹		1		NA	120
rs150632392^1,2		--	10851624(+)	`TAAATA/CAAGTG`	2	--	int¹		0	--	--	--	--
rs2166066^1,2	C,F,O,H,	--	10851658(+)	`AGGTCA/GGCAAA`	2	--	int¹		20		NS EA NA	2428
rs139786389^1,2		--	10851722(+)	`AGGAAC/TTTCTT`	2	--	ut3¹		0	--	--	--	--
rs7270^1,2	C,F,O,A,H,	--	10851772(+)	`ATGTTA/TTCCTC`	2	--	ut3¹		5		MN NA	378
rs182161188^1,2		--	10851786(+)	`TCATCC/TTAGAA`	2	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CSDA (10851676 - 10875953 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CSDA: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CSDA for disorders           About GeneDecksing

OMIM gene information: 603437    OMIM disorders: --

12 diseases for CSDA:    About MalaCards

lyme disease metastasis efficiency ataxia telangiectasia bloom syndrome

werner syndrome hepatocellular carcinoma ataxia arthritis

gastric cancer carcinoma tuberculosis mycobacterium tuberculosis

6 Novoseek disease relationships for CSDA gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
lyme neuroborreliosis	79.6	1	14648148 (1)
lyme disease	72.4	4	16081885 (1), 10473582 (1), 11825956 (1), 10650211 (1)
lyme arthritis	66.8	2	12792865 (1), 18279004 (1)
shock	48.2	16	10716181 (2), 11262979 (2), 10518954 (1), 17661445 (1) (see all 13)
hepatocellular carcinoma	17	16	16243807 (7), 16865284 (1), 15313206 (1)
carcinoma	0	1	16508013 (1)

Human Genome Epidemiology (HuGE) Navigator: CSDA (1 document)

Export disorders for CSDA gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CSDA gene, integrated from 9 sources (see all 110):
(articles sorted by number of sources associating them with CSDA)

Utopia: connect your pdf to the dynamic
world of online information

Cold shock domain proteins repress transcription from the GM-CSF promoter. (PubMed id 8710501)^{1, 2, 3} Coles L.S....Shannon M.F. (1996)
Two human genes isolated by a novel method encode DNA-binding proteins containing a common region of homology. (PubMed id 2977358)^{1, 2, 3} Sakura H.... Ishii S. (1988)
Characterization of the gene for dbpA, a family member of the nucleic-acid-binding proteins containing a cold-shock domain. (PubMed id 7628487)^{1, 2, 9} Kudo S.... Fukuda M. (1995)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Upregulation of human DNA binding protein A (dbpA) in gastric cancer cells. (PubMed id 19749785)^{1, 9} Wang G.R....He D.L. (2009)
Transcription of dbpA, a Y box binding protein, is positively regulated by E2F1: implications in hepatocarcinogenesis. (PubMed id 15313206)^{1, 9} Arakawa Y....Hino O. (2004)
Somatic mutation and SNP in the promoter of dbpA and human hepatocarcinogenesis. (PubMed id 12239625)^{1, 9} Hayashi J....Hino O. (2002)
Phosphorylation of cold shock domain/Y-box proteins by ERK2 and GSK3beta and repression of the human VEGF promoter. (PubMed id 16198352)^{1, 9} Coles L.S....Goodall G.J. (2005)
Regulation of PCNA and cyclin D1 expression and epithelial morphogenesis by the ZO-1-regulated transcription factor ZONAB/DbpA. (PubMed id 16508013)^{1, 9} Sourisseau T....Balda M.S. (2006)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 8531	HGNC: 2428	AceView: CSDA	Ensembl:ENSG00000060138	euGenes: HUgn8531
ECgene: CSDA	Kegg: 8531	H-InvDB: CSDA

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CSDA	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CSDA gene
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Patent Information for CSDA gene:
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cold shock domain protein A

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cold shock domain protein A

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