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CSAG family, member 2(Previous names: CSAG family, member 3B )
(Previous symbol: CSAG3B)
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Aliases
for CSAG2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
Subcategory (RNA class): antisense
Quality score for this RNA gene is 3
| Aliases |
|---|
| CSAG Family, Member 21 2 | | Taxol-Resistant-Associated Gene 3 Protein2 3 | | CT24.21 2 3 | | TRAG-32 3 | | TRAG31 2 3 | | Cancer/Testis Antigen Family 24, Member 22 | | CSAG3B1 2 | | Chondrosarcoma-Associated Gene 2/3 Protein2 | | CSAG Family, Member 3B1 2 | | Taxol Resistance Associated Gene 32 | | Cancer/Testis Antigen 24.22 3 | | CSAG3A3 |
Export aliases for CSAG2 gene to outside databasesPrevious GC identifers: GC0XM151547 GC0XP151680 |
Summaries
for CSAG2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: CSAG2_HUMAN, Q9Y5P2Function: Drug-resistance related protein, its expression is associated with the chemotherapy resistant and neoplasticphenotype. May also be linked to the malignant phenotype
|
Genomic Views
for CSAG2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NT_167198.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CSAG2 gene promoter:
p53 MyoD
Other transcription factors
Search SABiosciences Chromatin IP Primers for CSAG2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CSAG2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq28 Ensembl cytogenetic band: Xq28 HGNC cytogenetic band: Xq28CSAG2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP151922: view genomic region
(about GC identifiers)
Start:
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151,922,445 bp from pter |
End:
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151,928,738 bp from pter |
Size:
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6,294 bases |
Orientation:
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plus strand |
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Proteins
for CSAG2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CSAG2_HUMAN, Q9Y5P2 (See
protein sequence)Recommended Name: Chondrosarcoma-associated gene 2/3 protein Size: 127 amino acids; 14430 Da
Secondary accessions: O75605 Q0VDC3 Q96IU8Alternative splicing: 3 isoforms: Q9Y5P2-1 Q9Y5P2-2 Q9Y5P2-3 Explore the universe of human proteins at neXtProt for CSAG2: NX_Q9Y5P2
CSAG2 Protein expression data from MOPED and PaxDb: --
REFSEQ proteins (2 alternative transcripts):
NP_001074317.2 NP_004900.2
Human Recombinant Protein Products:
CSAG2 Antibody Products:
Assay Products for CSAG2: |
Protein
Domains /
Families
for CSAG2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q9Y5P2 |
Function
for CSAG2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CSAG2_HUMAN, Q9Y5P2Function: Drug-resistance related protein, its expression is associated with the chemotherapy resistant and neoplasticphenotype. May also be linked to the malignant phenotype
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CSAG2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CSAG2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for CSAG2 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CSAG2 |
|
Pathways & Interactions
for CSAG2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CSAG2
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table
CSAG2 for ontologies About GeneDecksing
|
Drugs & Compounds
for CSAG2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CSAG2
Search CenterWatch for drugs/clinical trials and news about CSAG2
|
Transcripts
for CSAG2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CSAG2 gene (2 alternative transcripts): NM_001080848.2 NM_004909.3 Unigene Clusters for CSAG2: CSAG family, member 2 Hs.721609 [show with all ESTs], Hs.735281 , Hs.741932 [show with all ESTs]Unigene Representative Sequences: BM807926, BF792369, NM_0011298282 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000370292(uc004fgk.3 uc004fgl.3 uc004fgm.3) ENST00000439173(uc004fgo.3 uc004fgn.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CSAG2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CSAG2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): CSAG2 (NM_004909) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CSAG2 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CSAG2 |
Additional cDNA sequence: AJ844639.1 BC119734.1 BC119735.1 9 DOTS entries: DT.100810376 DT.70100663 DT.121277722 DT.95271762 DT.100754650 DT.121277708 DT.121277704 DT.91714879 DT.95271760
GeneLoc Exon Structure
|
Expression
for CSAG2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| Expression evidence for CSAG2:none
CSAG2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGCAAAATG
About this image
Genevestigator expression for CSAG2
SOURCE GeneReport for Unigene clusters: Hs.721609 Hs.735281 Hs.741932
UniProtKB/Swiss-Prot: CSAG2_HUMAN, Q9Y5P2Tissue specificity: Weakly expressed in kidney. Expressed in various tumor cell lines including carcinomas, myeloid andlymphoid malignancies, melanomas and prostate cancer. Overexpressed in taxol-resistant breast cancer line MDA 435TRand the doxorubicin-resistant multiple myelanoma lines RPMI-8226/Dox40 and RPMI-8226/MDR10V
SABiosciences Custom PCR Arrays for CSAG2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CSAG2
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat CSAG2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CSAG2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CSAG2 |
Orthologs
for CSAG2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for CSAG2 (if available)
TreeFam Gene Tree for CSAG2 (if available) |
Paralogs
for CSAG2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CSAG2 gene
- CSAG3
1 SIMAP similar gene for CSAG2 using alignment to 2 protein entries: CSAG2_HUMAN (see all proteins):CSAG1
CSAG2 for paralogs About GeneDecksing
|
Genomic Variants
for CSAG2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CSAG2 (151922445 - 151928738 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CSAG2
1 CNV: 3273 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for CSAG2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CSAG2 for disorders About GeneDecksing
9  diseases for CSAG2: About MalaCardschondrosarcoma ovarian carcinoma esophageal cancer esophagitis
prostate cancer breast cancer prostatitis melanoma
carcinoma
Export disorders for CSAG2 gene to outside databases
|
Publications
for CSAG2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CSAG2 gene, integrated from 9 sources (see all 21):
(articles sorted by number of sources associating them with CSAG2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- TRAG-3, a novel gene, isolated from a taxol-resistant ovarian carcinoma cell line. (PubMed id 10095106)1, 2, 3 Duan Z.... Seiden M.V. (1999)
- Upregulation of TRAG3 gene in urothelial carcinoma of the bladder. (PubMed id 20734393)1 Karam J.A....Hsieh J.T. (2011)
- Human tumor antigen-specific helper and regulatory T cells share common epitope specificity but exhibit distinct T cell repertoire. (PubMed id 20483736)1 Fourcade J....Zarour H.M. (2010)
- A shared promoter region suggests a common ancestor for the human VCX/Y, SPANX, and CSAG gene families and the murine CYPT family. (PubMed id 17342728)1 Hansen M.A....Leffers H. (2008)
- Coordinated expression of clustered cancer/testis genes encoded in a large inverted repeat DNA structure. (PubMed id 18395366)1 Bredenbeck A....Losch F.O. (2008)
- Taxol-resistance-associated gene-3 (TRAG-3/CSAG2) expression is predictive for clinical outcome in ovarian carcinoma patients. (PubMed id 17216190)1 Materna V....Lage H. (2007)
- Spontaneous CD4+ T cell responses against TRAG-3 in patients with melanoma and breast cancers. (PubMed id 16888034)1 Janjic B....Zarour H.M. (2006)
- Expression of the TRAG-3 gene in human esophageal cancer: the frequent synchronous expression of MAGE-3 gene. (PubMed id 16685391)1 Ohta M....Mori M. (2006)
- Spontaneous T-cell responses against peptides derived from the Taxol resistance-associated gene-3 (TRAG-3) protein in cancer patients. (PubMed id 15580499)1 Meier A....Thor Straten P. (2005)
- Epigenetic regulation of the taxol resistance-associated gene TRAG-3 in human tumors. (PubMed id 15120907)1 Yao X....Hoffman A.R. (2004)
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External Searches for CSAG2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing CSAG2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CSAG2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CSAG2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CSAG2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CSAG2 gene:
Search GeneIP for patents involving CSAG2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CSAG2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CSAG2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CSAG2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CSAG2 | | | OriGene Protein Over-expression Lysate for CSAG2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CSAG2 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CSAG2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CSAG2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CSAG2 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CSAG2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CSAG2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CSAG2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CSAG2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CSAG2 |
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| | | | Search Tocris compounds for CSAG2 |
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 | | | CSAG2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | ThermoFisher Antibodies for CSAG2 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CSAG2 |
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