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Aliases for CSAG2 Gene

Aliases for CSAG2 Gene

  • CSAG Family, Member 2 2 3
  • Taxol-Resistant-Associated Gene 3 Protein 3 4
  • Cancer/Testis Antigen 24.2 3 4
  • CSAG Family, Member 3B 2 3
  • CT24.2 3 4
  • TRAG-3 3 4
  • TRAG3 3 4
  • Chondrosarcoma-Associated Gene 2/3 Protein-Like 3
  • Cancer/Testis Antigen Family 24, Member 2 3
  • Taxol Resistance Associated Gene 3 3
  • Cancer/Testis Antigen Family 24 2
  • CSAG2 CSAG3 4
  • Member 2 2
  • CSAG3A 4
  • CSAG3B 3

External Ids for CSAG2 Gene

Previous HGNC Symbols for CSAG2 Gene

  • CSAG3B

Previous GeneCards Identifiers for CSAG2 Gene

  • GC0XM151547
  • GC0XP151680
  • GC0XP151922

Summaries for CSAG2 Gene

GeneCards Summary for CSAG2 Gene

CSAG2 (CSAG Family, Member 2) is a Protein Coding gene. Diseases associated with CSAG2 include chondrosarcoma. An important paralog of this gene is CSAG3.

UniProtKB/Swiss-Prot for CSAG2 Gene

  • Drug-resistance related protein, its expression is associated with the chemotherapy resistant and neoplastic phenotype. May also be linked to the malignant phenotype

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSAG2 Gene

Genomics for CSAG2 Gene

Regulatory Elements for CSAG2 Gene

Transcription factor binding sites by QIAGEN in the CSAG2 gene promoter:

Genomic Location for CSAG2 Gene

152,708,261 bp from pter
152,714,549 bp from pter
6,289 bases
Minus strand

Genomic View for CSAG2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for CSAG2 Gene

Proteins for CSAG2 Gene

  • Protein details for CSAG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Chondrosarcoma-associated gene 2/3 protein
    Protein Accession:
    Secondary Accessions:
    • O75605
    • Q0VDC3
    • Q96IU8

    Protein attributes for CSAG2 Gene

    127 amino acids
    Molecular mass:
    14430 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CSAG2 Gene


neXtProt entry for CSAG2 Gene

Proteomics data for CSAG2 Gene at MOPED

Post-translational modifications for CSAG2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for CSAG2 Gene

Domains & Families for CSAG2 Gene

Protein Domains for CSAG2 Gene


Suggested Antigen Peptide Sequences for CSAG2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CSAG2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CSAG2 Gene

Function for CSAG2 Gene

Molecular function for CSAG2 Gene

UniProtKB/Swiss-Prot Function:
Drug-resistance related protein, its expression is associated with the chemotherapy resistant and neoplastic phenotype. May also be linked to the malignant phenotype

Phenotypes for CSAG2 Gene

genes like me logo Genes that share phenotypes with CSAG2: view

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CSAG2 Gene

Localization for CSAG2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for CSAG2 Gene

Pathways & Interactions for CSAG2 Gene

SuperPathways for CSAG2 Gene

No Data Available

Interacting Proteins for CSAG2 Gene

Gene Ontology (GO) - Biological Process for CSAG2 Gene


No data available for Pathways by source and SIGNOR curated interactions for CSAG2 Gene

Drugs & Compounds for CSAG2 Gene

No Compound Related Data Available

Transcripts for CSAG2 Gene

mRNA/cDNA for CSAG2 Gene

(2) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for CSAG2 Gene

No ASD Table

Relevant External Links for CSAG2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CSAG2 Gene

mRNA expression in normal human tissues for CSAG2 Gene

mRNA differential expression in normal tissues according to GTEx for CSAG2 Gene

This gene is overexpressed in Testis (x22.6), Brain - Putamen (basal ganglia) (x6.5), Brain - Caudate (basal ganglia) (x5.4), Spleen (x5.2), Brain - Frontal Cortex (BA9) (x5.0), and Prostate (x4.3).

mRNA Expression by UniProt/SwissProt for CSAG2 Gene

Tissue specificity: Weakly expressed in kidney. Expressed in various tumor cell lines including carcinomas, myeloid and lymphoid malignancies, melanomas and prostate cancer. Overexpressed in taxol-resistant breast cancer line MDA 435TR and the doxorubicin-resistant multiple myelanoma lines RPMI-8226/Dox40 and RPMI-8226/MDR10V
genes like me logo Genes that share expression patterns with CSAG2: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for CSAG2 Gene

Orthologs for CSAG2 Gene

Evolution for CSAG2 Gene

Gene Tree for CSAG2 (if available)
Gene Tree for CSAG2 (if available)

No data available for Orthologs for CSAG2 Gene

Paralogs for CSAG2 Gene

Paralogs for CSAG2 Gene

(1) SIMAP similar genes for CSAG2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CSAG2: view

Variants for CSAG2 Gene

Sequence variations from dbSNP and Humsavar for CSAG2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1894362 -- 152,708,926(-) GAGAC(A/G)CTGGT reference, missense, nc-transcript-variant
rs4828722 -- 152,707,910(-) tgggc(A/G)ttttt downstream-variant-500B
rs6627641 -- 152,708,942(+) AGTCT(A/G)CTCCA synonymous-codon, reference, nc-transcript-variant
rs6627667 -- 152,710,839(-) tatat(A/G)tatat upstream-variant-2KB, intron-variant
rs112223342 -- 152,710,245(-) CTTAA(C/T)ATTGT upstream-variant-2KB, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CSAG2 Gene

Variant ID Type Subtype PubMed ID
dgv2493e1 CNV Complex 17122850

Relevant External Links for CSAG2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for CSAG2 Gene

Disorders for CSAG2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CSAG2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
  • chondrosarcoma of bone
- elite association
Search CSAG2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CSAG2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CSAG2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CSAG2 Gene

Publications for CSAG2 Gene

  1. TRAG-3, a novel gene, isolated from a taxol-resistant ovarian carcinoma cell line. (PMID: 10095106) Duan Z. … Seiden M.V. (Gene 1999) 2 67
  2. Upregulation of TRAG3 gene in urothelial carcinoma of the bladder. (PMID: 20734393) Karam J.A. … Hsieh J.T. (Int. J. Cancer 2011) 67
  3. Human tumor antigen-specific helper and regulatory T cells share common epitope specificity but exhibit distinct T cell repertoire. (PMID: 20483736) Fourcade J. … Zarour H.M. (J. Immunol. 2010) 67
  4. A shared promoter region suggests a common ancestor for the human VCX/Y, SPANX, and CSAG gene families and the murine CYPT family. (PMID: 17342728) Hansen M.A. … Leffers H. (Mol. Reprod. Dev. 2008) 67
  5. Coordinated expression of clustered cancer/testis genes encoded in a large inverted repeat DNA structure. (PMID: 18395366) Bredenbeck A. … Losch F.O. (Gene 2008) 67

Products for CSAG2 Gene

Sources for CSAG2 Gene

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