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Aliases for CSAG2 Gene

Aliases for CSAG2 Gene

  • CSAG Family, Member 2 2 3
  • Taxol-Resistant-Associated Gene 3 Protein 3 4
  • Cancer/Testis Antigen 24.2 3 4
  • CSAG Family, Member 3B 2 3
  • CT24.2 3 4
  • TRAG-3 3 4
  • TRAG3 3 4
  • Chondrosarcoma-Associated Gene 2/3 Protein-Like 3
  • Chondrosarcoma-Associated Gene 2/3 Protein 3
  • Cancer/Testis Antigen Family 24, Member 2 3
  • Taxol Resistance Associated Gene 3 3
  • Cancer/Testis Antigen Family 24 2
  • CSAG2 CSAG3 4
  • Member 2 2
  • CSAG3A 4
  • CSAG3B 3

External Ids for CSAG2 Gene

Previous HGNC Symbols for CSAG2 Gene

  • CSAG3B

Previous GeneCards Identifiers for CSAG2 Gene

  • GC0XM151547
  • GC0XP151680
  • GC0XP151922

Summaries for CSAG2 Gene

GeneCards Summary for CSAG2 Gene

CSAG2 (CSAG Family, Member 2) is a Protein Coding gene. Diseases associated with CSAG2 include chondrosarcoma and esophageal cancer. An important paralog of this gene is CSAG3.

UniProtKB/Swiss-Prot for CSAG2 Gene

  • Drug-resistance related protein, its expression is associated with the chemotherapy resistant and neoplastic phenotype. May also be linked to the malignant phenotype

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSAG2 Gene

Genomics for CSAG2 Gene

Regulatory Elements for CSAG2 Gene

Transcription factor binding sites by QIAGEN in the CSAG2 gene promoter:

Genomic Location for CSAG2 Gene

152,708,261 bp from pter
152,714,549 bp from pter
6,289 bases
Minus strand

Genomic View for CSAG2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CSAG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSAG2 Gene

Proteins for CSAG2 Gene

  • Protein details for CSAG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Chondrosarcoma-associated gene 2/3 protein
    Protein Accession:
    Secondary Accessions:
    • O75605
    • Q0VDC3
    • Q96IU8

    Protein attributes for CSAG2 Gene

    127 amino acids
    Molecular mass:
    14430 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CSAG2 Gene


neXtProt entry for CSAG2 Gene

Proteomics data for CSAG2 Gene at MOPED

Post-translational modifications for CSAG2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for CSAG2 Gene

Domains for CSAG2 Gene

Protein Domains for CSAG2 Gene


Suggested Antigen Peptide Sequences for CSAG2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CSAG2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CSAG2 Gene

Function for CSAG2 Gene

Molecular function for CSAG2 Gene

UniProtKB/Swiss-Prot Function:
Drug-resistance related protein, its expression is associated with the chemotherapy resistant and neoplastic phenotype. May also be linked to the malignant phenotype

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CSAG2 Gene

Localization for CSAG2 Gene

Subcellular locations from

Jensen Localization Image for CSAG2 Gene COMPARTMENTS Subcellular localization image for CSAG2 gene
Compartment Confidence
cytosol 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CSAG2 Gene

Pathways for CSAG2 Gene

SuperPathways for CSAG2 Gene

No Data Available

Interacting Proteins for CSAG2 Gene

Gene Ontology (GO) - Biological Process for CSAG2 Gene


No data available for Pathways by source for CSAG2 Gene

Transcripts for CSAG2 Gene

mRNA/cDNA for CSAG2 Gene

(2) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for CSAG2 Gene

No ASD Table

Relevant External Links for CSAG2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CSAG2 Gene

mRNA expression in normal human tissues for CSAG2 Gene

mRNA differential expression in normal tissues according to GTEx for CSAG2 Gene

This gene is overexpressed in Testis (22.6), Brain - Putamen (basal ganglia) (6.5), Brain - Caudate (basal ganglia) (5.4), Spleen (5.2), Brain - Frontal Cortex (BA9) (5.0), and Prostate (4.3).

mRNA Expression by UniProt/SwissProt for CSAG2 Gene

Tissue specificity: Weakly expressed in kidney. Expressed in various tumor cell lines including carcinomas, myeloid and lymphoid malignancies, melanomas and prostate cancer. Overexpressed in taxol-resistant breast cancer line MDA 435TR and the doxorubicin-resistant multiple myelanoma lines RPMI-8226/Dox40 and RPMI-8226/MDR10V
genes like me logo Genes that share expressions with CSAG2: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Expression partners for CSAG2 Gene

Orthologs for CSAG2 Gene

Evolution for CSAG2 Gene

Gene Tree for CSAG2 (if available)
Gene Tree for CSAG2 (if available)

No data available for Orthologs for CSAG2 Gene

Paralogs for CSAG2 Gene

Paralogs for CSAG2 Gene

(1) SIMAP similar genes for CSAG2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CSAG2: view

Variants for CSAG2 Gene

Sequence variations from dbSNP and Humsavar for CSAG2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs113506057 -- 152,708,044(-) ACACT(G/T)TAGCA downstream-variant-500B
rs199514086 -- 152,708,926(-) GAGAC(A/G)CTGGT reference, missense
rs200100719 -- 152,709,114(-) CTTCC(-/AT)AATGT upstream-variant-2KB
rs112223342 -- 152,710,245(-) CTTAA(C/T)ATTGT upstream-variant-2KB
rs6627667 -- 152,710,839(-) tatat(A/G)tatat upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CSAG2 Gene

Variant ID Type Subtype PubMed ID
dgv2493e1 CNV Complex 17122850

Relevant External Links for CSAG2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSAG2 Gene

Disorders for CSAG2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for CSAG2 Gene in MalaCards »

(2) Diseases for CSAG2 Gene

genes like me logo Genes that share disorders with CSAG2: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for CSAG2 Gene

Publications for CSAG2 Gene

  1. TRAG-3, a novel gene, isolated from a taxol-resistant ovarian carcinoma cell line. (PMID: 10095106) Duan Z. … Seiden M.V. (Gene 1999) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Spontaneous T-cell responses against peptides derived from the Taxol resistance-associated gene-3 (TRAG-3) protein in cancer patients. (PMID: 15580499) Meier A. … Thor Straten P. (Cancer Immunol. Immunother. 2005) 3
  4. Expression of the TRAG-3 gene in human esophageal cancer: the frequent synchronous expression of MAGE-3 gene. (PMID: 16685391) Ohta M. … Mori M. (Oncol. Rep. 2006) 3
  5. Taxol-resistance-associated gene-3 (TRAG-3/CSAG2) expression is predictive for clinical outcome in ovarian carcinoma patients. (PMID: 17216190) Materna V. … Lage H. (Virchows Arch. 2007) 3

Products for CSAG2 Gene

Sources for CSAG2 Gene

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