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Aliases for CSAG1 Gene

Aliases for CSAG1 Gene

  • Chondrosarcoma Associated Gene 1 2 3 5
  • Cancer/Testis Antigen CSAGE 3 4
  • Cancer/Testis Antigen 24.1 3 4
  • CT24.1 3 4
  • CSAGE 3 4
  • Cancer/Testis Antigen Family 24, Member 1 3
  • Cancer/Testis Antigen Family 24 2
  • Member 1 2

External Ids for CSAG1 Gene

Previous GeneCards Identifiers for CSAG1 Gene

  • GC0XP151573
  • GC0XP151653
  • GC0XP151903
  • GC0XP140705

Summaries for CSAG1 Gene

Entrez Gene Summary for CSAG1 Gene

  • This gene encodes a member of a family of tumor antigens. The protein is expressed in chondrosarcomas, but may also be expressed in normal tissues such as testis. Alternative splicing of this gene results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for CSAG1 Gene

CSAG1 (Chondrosarcoma Associated Gene 1) is a Protein Coding gene. Diseases associated with CSAG1 include Chondrosarcoma.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSAG1 Gene

Genomics for CSAG1 Gene

Regulatory Elements for CSAG1 Gene

Enhancers for CSAG1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CSAG1 on UCSC Golden Path with GeneCards custom track

Promoters for CSAG1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CSAG1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CSAG1 Gene

Chromosome:
X
Start:
152,727,484 bp from pter
End:
152,733,736 bp from pter
Size:
6,253 bases
Orientation:
Minus strand

Genomic View for CSAG1 Gene

Genes around CSAG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CSAG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CSAG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSAG1 Gene

Proteins for CSAG1 Gene

  • Protein details for CSAG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PB30-CSAG1_HUMAN
    Recommended name:
    Putative chondrosarcoma-associated gene 1 protein
    Protein Accession:
    Q6PB30
    Secondary Accessions:
    • A6NE22

    Protein attributes for CSAG1 Gene

    Size:
    78 amino acids
    Molecular mass:
    8669 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CSAG1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CSAG1 Gene

Proteomics data for CSAG1 Gene at MOPED

Post-translational modifications for CSAG1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CSAG1 Gene

No data available for DME Specific Peptides for CSAG1 Gene

Domains & Families for CSAG1 Gene

Protein Domains for CSAG1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for CSAG1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CSAG1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CSAG1 Gene

Function for CSAG1 Gene

genes like me logo Genes that share phenotypes with CSAG1: view

Animal Model Products

CRISPR Products

miRNA for CSAG1 Gene

miRTarBase miRNAs that target CSAG1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CSAG1 Gene

Localization for CSAG1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CSAG1 Gene COMPARTMENTS Subcellular localization image for CSAG1 gene
Compartment Confidence
nucleus 3
cytosol 1
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CSAG1 Gene

Pathways & Interactions for CSAG1 Gene

SuperPathways for CSAG1 Gene

No Data Available

Interacting Proteins for CSAG1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000359310%0d%0a9606.ENSP00000377262%0d%0a9606.ENSP00000362931%0d%0a
Selected Interacting proteins: ENSP00000359310 for CSAG1 Gene via STRING

Gene Ontology (GO) - Biological Process for CSAG1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CSAG1 Gene

Drugs & Compounds for CSAG1 Gene

No Compound Related Data Available

Transcripts for CSAG1 Gene

mRNA/cDNA for CSAG1 Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CSAG1 Gene

Chondrosarcoma associated gene 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CSAG1 Gene

No ASD Table

Relevant External Links for CSAG1 Gene

GeneLoc Exon Structure for
CSAG1
ECgene alternative splicing isoforms for
CSAG1

Expression for CSAG1 Gene

mRNA expression in normal human tissues for CSAG1 Gene

mRNA differential expression in normal tissues according to GTEx for CSAG1 Gene

This gene is overexpressed in Brain - Caudate (basal ganglia) (x5.1), Brain - Putamen (basal ganglia) (x5.1), Testis (x5.0), Brain - Frontal Cortex (BA9) (x4.6), Brain - Anterior cingulate cortex (BA24) (x4.6), Brain - Hippocampus (x4.1), and Brain - Substantia nigra (x4.1).

SOURCE GeneReport for Unigene cluster for CSAG1 Gene Hs.423718

mRNA Expression by UniProt/SwissProt for CSAG1 Gene

Q6PB30-CSAG1_HUMAN
Tissue specificity: Expressed in chondrosarcoma, melanoma, cartilage and testis, but not in other normal tissues.
genes like me logo Genes that share expression patterns with CSAG1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for CSAG1 Gene

Orthologs for CSAG1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for CSAG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CSAG1 36
  • 90 (a)
OneToOne
Species with no ortholog for CSAG1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CSAG1 Gene

ENSEMBL:
Gene Tree for CSAG1 (if available)
TreeFam:
Gene Tree for CSAG1 (if available)

Paralogs for CSAG1 Gene

(2) SIMAP similar genes for CSAG1 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for CSAG1 Gene

genes like me logo Genes that share paralogs with CSAG1: view

No data available for Paralogs for CSAG1 Gene

Variants for CSAG1 Gene

Sequence variations from dbSNP and Humsavar for CSAG1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
VAR_032868 -
rs2515848 - 152,727,846(-) ACCCA(A/G)AAGGG reference, missense
rs1974444 -- 152,731,141(-) ACACT(C/T)GCCTA intron-variant
rs2471783 -- 152,730,659(-) agact(A/G)ggtgg intron-variant
rs2471784 -- 152,730,438(-) catga(A/T)ctagt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CSAG1 Gene

Variant ID Type Subtype PubMed ID
dgv2493e1 CNV Complex 17122850

Variation tolerance for CSAG1 Gene

Residual Variation Intolerance Score: 85.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.31; 70.53% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CSAG1 Gene

Disorders for CSAG1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CSAG1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
chondrosarcoma
  • chondrosarcoma of bone
- elite association - COSMIC cancer census association via MalaCards
Search CSAG1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CSAG1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CSAG1
genes like me logo Genes that share disorders with CSAG1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CSAG1 Gene

Publications for CSAG1 Gene

  1. Cancer/testis antigen CSAGE is concurrently expressed with MAGE in chondrosarcoma. (PMID: 12039054) Lin C. … Terek R.M. (Gene 2002) 2 3 4 67
  2. Analysis of compensatory substitution and gene evolution on the MAGEA/CSAG-palindrome of the primate X chromosomes. (PMID: 23257410) Qi Y. … Ai D. (Comput Biol Chem 2013) 3
  3. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M. … Gstaiger M. (Cell Rep 2013) 3
  4. Exome sequencing in a family segregating for celiac disease. (PMID: 21627641) Szperl A.M. … Zheng H.C. (Clin. Genet. 2011) 3
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for CSAG1 Gene

Sources for CSAG1 Gene

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