Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CSAD Gene

protein-coding   GIFtS: 59
GCID: GC12M053551

Cysteine Sulfinic Acid Decarboxylase

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cysteine Sulfinic Acid Decarboxylase1 2     EC 4.1.1.293 8
P-Selectin Cytoplasmic Tail-Associated Protein1 2     PCAP2
Cysteine-Sulfinate Decarboxylase2 3     Cysteine Sulfinic Acid Decarboxylase-Related Protein2
Sulfinoalanine Decarboxylase2 3     EC 4.1.18
CSD2 3     

External Ids:    HGNC: 189661   Entrez Gene: 513802   Ensembl: ENSG000001396317   UniProtKB: Q9Y6003   

Export aliases for CSAD gene to outside databases

Previous GC identifers: GC12M053710 GC12M053465 GC12M053268 GC12M051837 GC12M050594


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CSAD Gene:
This gene encodes a member of the group 2 decarboxylase family. A similar protein in rodents plays a role in
multiple biological processes as the rate-limiting enzyme in taurine biosynthesis, catalyzing the decarboxylation
of cysteinesulfinate to hypotaurine. Alternatively spliced transcript variants encoding multiple isoforms have
been observed for this gene. (provided by RefSeq, Sep 2011)

GeneCards Summary for CSAD Gene: 
CSAD (cysteine sulfinic acid decarboxylase) is a protein-coding gene. Diseases associated with CSAD include stiff-person syndrome, and pulmonary edema, and among its related super-pathways are Metabolic pathways and Beta-alanine metabolism. GO annotations related to this gene include pyridoxal phosphate binding and sulfinoalanine decarboxylase activity. An important paralog of this gene is DDC.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_029419.12  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CSAD gene promoter:
         E2F-4   E2F-3a   E2F-5   RP58   E2F-2   Tal-1beta   E47   HEN1   E2F-1   E2F   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CSAD promoter sequence
   Search SABiosciences Chromatin IP Primers for CSAD

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CSAD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.11-q14.3   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13.11-q14.3

CSAD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CSAD gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M053551:  view genomic region     (about GC identifiers)

Start:
53,551,447 bp from pter      End:
53,575,135 bp from pter
Size:
23,689 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CSAD_HUMAN, Q9Y600 (See protein sequence)
Recommended Name: Cysteine sulfinic acid decarboxylase  
Size: 493 amino acids; 55023 Da
Cofactor: Pyridoxal phosphate
Subunit: Homodimer
Sequence caution: Sequence=AAD32546.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAH98278.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAH98342.1;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAH99717.1; Type=Erroneous
initiation; Note=Translation N-terminally extended; Sequence=AAI05919.1; Type=Erroneous initiation;
Note=Translation N-terminally extended;
1 PDB 3D structure from and Proteopedia for CSAD:
2JIS (3D)    
Secondary accessions: A8K0U4 Q4QQH9 Q9UNJ5 Q9Y601
Alternative splicing: 3 isoforms:  Q9Y600-1   Q9Y600-2   Q9Y600-3   (No experimental confirmation available. Ref.4 (AAH98342) sequence is in conflict in position: 9:F->S)

Explore the universe of human proteins at neXtProt for CSAD: NX_Q9Y600

Explore proteomics data for CSAD at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y600

  • 4/7 DME Specific Peptides for CSAD (Q9Y600) (see all 7)
     YLFQQDK  PGGSISN  HPRFFNQL  VPFLVSAT 

    CSAD Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CSAD Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001231634.1  NP_001231635.1  NP_057073.4  

    ENSEMBL proteins: 
     ENSP00000267085   ENSP00000436800   ENSP00000369179   ENSP00000369175   ENSP00000415485  
     ENSP00000410648   ENSP00000449373   ENSP00000455618   ENSP00000390269   ENSP00000415314  
     ENSP00000401078   ENSP00000457264   ENSP00000369172   ENSP00000439419  
    Reactome Protein details: Q9Y600
    Human Recombinant Protein Products for CSAD: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CSAD
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CSAD
    GenScript Custom Purified and Recombinant Proteins Services for CSAD
    Novus Biologicals CSAD Protein
    Novus Biologicals CSAD Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CSAD 


    CSAD Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CSAD
    GenScript Custom Superior Antibodies Services for CSAD
    Novus Biologicals CSAD Antibodies
    Search for Antibodies for CSAD at Abcam
    Cloud-Clone Corp. Antibodies for CSAD 
    Search ThermoFisher Antibodies for CSAD
    LSBio Antibodies in human, mouse, rat for CSAD 

    Assay Products for CSAD: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CSAD
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CSAD
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CSAD 
    Cloud-Clone Corp. CLIAs for CSAD


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR002129 PyrdxlP-dep_de-COase
     IPR015422 PyrdxlP-dep_Trfase_major_sub2
     IPR015424 PyrdxlP-dep_Trfase
     IPR015421 PyrdxlP-dep_Trfase_major_sub1

    Graphical View of Domain Structure for InterPro Entry Q9Y600

    ProtoNet protein and cluster: Q9Y600

    UniProtKB/Swiss-Prot: CSAD_HUMAN, Q9Y600
    Similarity: Belongs to the group II decarboxylase family


    CSAD for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CSAD_HUMAN, Q9Y600
    Catalytic activity: 3-sulfino-L-alanine = hypotaurine + CO(2)

         Enzyme Numbers (IUBMB): EC 4.1.1.291 2 EC 4.1.12

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004782sulfinoalanine decarboxylase activity IEA--
    GO:0016829lyase activity ----
    GO:0016831carboxy-lyase activity ----
    GO:0030170pyridoxal phosphate binding IEA--
         
    CSAD for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CSAD 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CSAD

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CSAD 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CSAD 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CSAD
    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate CSAD (see all 13):
    hsa-miR-3685 hsa-miR-30c hsa-miR-3924 hsa-miR-30d hsa-miR-664 hsa-miR-337-3p hsa-miR-1305 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidCSAD 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CSAD
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CSAD

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CSAD
    Sirion Biotech Customized adenovirus for overexpression of CSAD

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CSAD (see all 8)
    OriGene ORF clones in mouse, rat for CSAD
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CSAD (NM_015989)
    Sino Biological Human cDNA Clone for CSAD
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CSAD
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSAD
    Sirion Biotech Customized lentivirus for stable overexpression of CSAD 
                         Customized lentivirus expression plasmids for stable overexpression of CSAD 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CSAD
    Search LifeMap BioReagents cell lines for CSAD
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSAD


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CSAD About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolism0.40
    Metabolic pathways0.40
    2Beta-alanine metabolism
    Beta-alanine metabolism0.90
    3Degradation of cysteine and homocysteine
    Degradation of cysteine and homocysteine0.62
    4Cysteine and methionine metabolism
    Sulfur amino acid metabolism0.37
    5L-cysteine degradation I
    taurine biosynthesis0.33

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for CSAD
        Beta-alanine metabolism


    1 GeneGo (Thomson Reuters) Pathway for CSAD
        Beta-alanine metabolism

    2 BioSystems Pathways for CSAD
        Trans-sulfuration pathway
    taurine biosynthesis


    4        Reactome Pathways for CSAD
        Metabolism
    Sulfur amino acid metabolism
    Degradation of cysteine and homocysteine
    Metabolism of amino acids and derivatives


    2         Kegg Pathways  (Kegg details for CSAD):
        Taurine and hypotaurine metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: CSAD_HUMAN, Q9Y600
    Pathway: Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 2/2


    CSAD for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CSAD

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/21 Interacting proteins for CSAD (Q9Y6002, 3 ENSP000002670854) via UniProtKB, MINT, STRING, and/or I2D (see all 21)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMN1Q166372, 3MINT-8271025 I2D: score=2 
    SMN2Q166372, 3MINT-8271025 I2D: score=2 
    ANXA1P040832, 3MINT-8247775 I2D: score=2 
    ANXA7P200732, 3MINT-8248230 I2D: score=2 
    CDKN1AP389362, 3MINT-8251760 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000096sulfur amino acid metabolic process TAS--
    GO:0000098sulfur amino acid catabolic process TAS--
    GO:0006520cellular amino acid metabolic process ----
    GO:0008152metabolic process ----
    GO:0019752carboxylic acid metabolic process ----

    CSAD for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CSAD for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CSAD

    8 HMDB Compounds for CSAD    About this table
    CompoundSynonyms CAS #PubMed Ids
    3-Sulfinoalanine3-Sulphino-L-alanine (see all 9)1115-65-7--
    5-L-Glutamyl-taurine5-Glutamyl-taurine ----
    Carbon dioxideCarbon oxide (see all 5)124-38-9--
    Cysteic acid2-Amino-3-sulfopropionate (see all 19)498-40-8--
    Hypotaurine2-Aminoethylsulfinate (see all 9)300-84-5--
    L-Cysteine(+)-2-Amino-3-mercaptopropionic acid (see all 37)52-90-4--
    Pyridoxal 5'-phosphateApolon B6 (see all 27)54-47-7--
    Taurine1-Aminoethane-2-sulfonate (see all 14)107-35-7--

    1 DrugBank Compound for CSAD    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Pyridoxal PhosphateCodecarboxylase (see all 9)54-47-7targetcofactor17139284 17016423 15070923

    6 Novoseek inferred chemical compound relationships for CSAD gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cysteine sulfinic acid 98 51 8740442 (5), 11455199 (3), 12436215 (3), 8912862 (2) (see all 21)
    taurine 81 38 8740442 (3), 10936171 (2), 9635049 (2), 12905652 (2) (see all 12)
    hypotaurine 77.3 3 8740442 (2)
    cysteine 48.8 9 14992268 (1), 10936171 (1), 11008216 (1), 12436215 (1) (see all 5)
    glutamate 32.8 7 11455199 (2), 8912862 (1), 9635049 (1)
    nitric oxide 0 2 11455199 (2)

    Search CenterWatch for drugs/clinical trials and news about CSAD

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CSAD gene (3 alternative transcripts): 
    NM_001244705.1  NM_001244706.1  NM_015989.4  

    Unigene Cluster for CSAD:

    Cysteine sulfinic acid decarboxylase
    Hs.279815  [show with all ESTs]
    Unigene Representative Sequence: NM_015989
    18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000267085(uc009zmt.3 uc010snx.2 uc001sby.3 uc001sbz.3)
    ENST00000475890(uc021qyd.1) ENST00000379850 ENST00000379846 ENST00000444623
    ENST00000453446 ENST00000490923 ENST00000490589 ENST00000485004 ENST00000548698
    ENST00000483632 ENST00000472908 ENST00000454442 ENST00000424845 ENST00000437073
    ENST00000491654 ENST00000424990 ENST00000498635
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CSAD
    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate CSAD (see all 13):
    hsa-miR-3685 hsa-miR-30c hsa-miR-3924 hsa-miR-30d hsa-miR-664 hsa-miR-337-3p hsa-miR-1305 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidCSAD 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CSAD
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CSAD
    Clone
    Products:
         
    OriGene clones in human, mouse for CSAD (see all 8)
    OriGene ORF clones in mouse, rat for CSAD
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CSAD (NM_015989)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CSAD
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSAD
    Sirion Biotech Customized lentivirus for stable overexpression of CSAD 
                         Customized lentivirus expression plasmids for stable overexpression of CSAD 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CSAD
    OriGene qSTAR qPCR primer pairs in human, mouse for CSAD
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CSAD
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CSAD
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CSAD

    Additional mRNA sequence: 

    AB044561.1 AF116545.1 AF116546.1 AF116547.1 AF116548.1 AK122681.1 AK289659.1 AK315265.1 
    BC052249.1 BC098278.1 BC098342.1 BC099717.1 BC105918.1 

    12 DOTS entries:

    DT.99996082  DT.95120528  DT.108407  DT.95180747  DT.75195032  DT.91738127  DT.86857445  DT.91738133 
    DT.75171452  DT.91986736  DT.100746310  DT.121208749 

    24/64 AceView cDNA sequences (see all 64):

    AI460030 AF116547 AI566429 AF116548 AI022542 AW845110 AI743923 BF223281 
    BG315155 BQ772641 AL548656 BC047466 AI807766 AW024777 NM_015989 AF116545 
    BC052249 AL573129 BX392733 CK822518 AW450257 AB044561 BQ774374 BP357045 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CSAD (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18
    SP1:                                            -     -     -                 -           -     -                                                   
    SP2:                                                                          -           -     -                                                   
    SP3:                                                                          -           -     -           -                                       
    SP4:                                                                                      -     -                                                   
    SP5:                                                  -     -                 -                                                                     


    ECgene alternative splicing isoforms for CSAD

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CSAD expression in normal human tissues (normalized intensities)      CSAD embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CSAD Expression
    About this image


    CSAD expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Liver (Hepatobiliary System)
             Perivenous Hepatocytes Liver Lobule

    See CSAD Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CSAD

    SOURCE GeneReport for Unigene cluster: Hs.279815
        SABiosciences Custom PCR Arrays for CSAD
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CSAD
    OriGene qSTAR qPCR primer pairs in human, mouse for CSAD
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CSAD
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CSAD
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CSAD
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSAD

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CSAD gene from 5/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Csad1 , 5 cysteine sulfinic acid decarboxylase1, 5 88.24(n)1
    89.66(a)1
      15 (57.35 cM)5
    2462771  NM_144942.41  NP_659191.11 
     1021769985 
    chicken
    (Gallus gallus)
    Aves CSAD1 cysteine sulfinic acid decarboxylase 72.88(n)
    72.88(a)
      426184  XM_423847.3  XP_423847.3 
    lizard
    (Anolis carolinensis)
    Reptilia CSAD6
    Uncharacterized protein
    66(a)
    1 ↔ 1
    2(70297982-70319798)
    zebrafish
    (Danio rerio)
    Actinopterygii 570446572   -- 73.41(n)    57044657 
    fruit fly
    (Drosophila melanogaster)
    Insecta b3 aspartate 1-decarboxylase 52(a)
    (best of 2)
      2 34D5   --


    ENSEMBL Gene Tree for CSAD (if available)
    TreeFam Gene Tree for CSAD (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CSAD gene
    DDC2  GAD12  GADL12  HDC2  GAD22  
    7 SIMAP similar genes for CSAD using alignment to 11 protein entries:     CSAD_HUMAN (see all proteins):
    pcap    GADL1    GAD65    GAD2    GAD1    DDC
    HDC

    CSAD for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/598 SNPs in CSAD are shown (see all 598)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1119585981,2
    C--50605831(+) ATCTC-/AAAAAA 2 -- int11Minor allele frequency- A:0.00CSA 2
    rs2007271431,2
    C--50615138(+) ATCTC-/AAAAAA 2 -- int10--------
    rs2010984131,2
    --50615142(+) CAAAA-/AAAAAT
            
    AAAAA
    2 -- int10--------
    rs358769161,2
    C--53385017(+) GCTAG-/GATTAT 3 -- ds50011Minor allele frequency- G:0.00CSA 2
    rs1844100121,2
    --53385091(+) TTGATG/TGAATG 3 -- ds50010--------
    rs1435748031,2
    C--53385095(+) TTGAA-/TGTTT 
            
    TGTTT
    3 -- ds50010--------
    rs1905212421,2
    --53385110(+) TGCTTC/TGTTTT 3 -- ds50010--------
    rs1511665541,2
    --53385161(+) ATGGCA/GTGATC 3 -- ds50010--------
    rs1418014951,2
    --53385185(+) AGCTCC/TGCTTC 3 -- ds50010--------
    rs1470824491,2
    --53385203(+) CAAGCA/GATTCT 3 -- ds50010--------

    HapMap Linkage Disequilibrium report for CSAD (53551447 - 53575135 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for CSAD:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2661808CNV Deletion23128226
    nsv713CNV Insertion18451855
    nsv469404CNV Loss19166990
    nsv470294CNV Loss18288195
    nsv517066CNV Loss19592680
    nsv470295CNV Gain18288195
    nsv832417CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CSAD
    DNA2.0 Custom Variant and Variant Library Synthesis for CSAD

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    4 diseases for CSAD:    About MalaCards
    stiff-person syndrome    pulmonary edema    respiratory failure    hepatocellular carcinoma

    3 diseases from the University of Copenhagen DISEASES database for CSAD:
    Disuse amblyopia     Prostate cancer     Respiratory failure

    CSAD for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for CSAD gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    autoimmune diseases 27.2 3 15070923 (2)


    Export disorders for CSAD gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CSAD gene, integrated from 9 sources (see all 32):
    (articles sorted by number of sources associating them with CSAD)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2, 3 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Cloning of murine cysteine sulfinic acid decarboxylase and its mRNA expression in murine tissues. (PubMed id 11997111)1, 9 Park E....Schuller-Levis G. (2002)
    4. Analysis of antibody reactivity against cysteine sulfinic acid decarboxylase, a pyridoxal phosphate-dependent enzyme, in endocrine autoimmune disease. (PubMed id 15070923)7, 9 Skoldberg F....Kampe O. (2004)
    5. Mechanism of cysteine-dependent inactivation of aspart ate/glutamate/cysteine sulfinic acid a-decarboxylases. (PubMed id 22718265)1 Liu P....Li J. (2013)
    6. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (2012)
    7. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    9. How many drug targets are there? (PubMed id 17139284)7 Overington J.P....Hopkins A.L. (2006)
    10. Drugs, their targets and the nature and number of dru g targets. (PubMed id 17016423)7 Imming P....Meyer A. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51380 HGNC: 18966 AceView: CSAD Ensembl:ENSG00000139631 euGenes: HUgn51380
    ECgene: CSAD Kegg: 51380 H-InvDB: CSAD

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CSAD Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CSAD Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CSAD gene:
    Search GeneIP for patents involving CSAD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for CSAD  
     OriGene qPCR primer pairs and template standards for CSAD   OriGene Protein Over-expression Lysate for CSAD  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for CSAD  
     OriGene qSTAR qPCR primer pairs in human, mouse for CSAD   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for CSAD   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CSAD   OriGene Custom Protein Services for CSAD  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CSAD
     QIAGEN SeqTarget long-range PCR primers for resequencing CSAD
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CSAD
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CSAD
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CSAD
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CSAD
     GenScript Custom Purified and Recombinant Proteins Services for CSAD GenScript cDNA clones with any tag delivered in your preferred vector for CSAD
     GenScript Custom Assay Services for CSAD GenScript Custom Superior Antibodies Services for CSAD
     GenScript Custom overexpressing Cell Line Services for CSAD CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CSAD promoter
     Search Chromatin IP Primers for CSAD
     RT2 qPCR Primer Assay in human, mouse, rat CSAD
     Search GNC Networks for CSAD
     SABiosciences Custom PCR Arrays for CSAD
     Search Tocris compounds for CSAD
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for CSAD
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CSAD antibodies
     CSAD proteins
     CSAD lysates
     Search for Antibodies for CSAD at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for CSAD
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for CSAD
     Antibodies for CSAD
     ELISAs for CSAD
     CLIAs for CSAD
     Search LifeMap BioReagents cell lines for CSAD
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSAD
     SwitchGear 3'UTR luciferase reporter plasmids for CSAD
     SwitchGear Promoter luciferase reporter plasmids for CSAD
     Search ThermoFisher Antibodies for CSAD
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CSAD
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CSAD
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CSAD
    Customized:
     lentivirus for stable overexpression of CSAD
     lentivirus expression plasmids for stable overexpression of CSAD
     adenovirus for overexpression of CSAD
     LSBio Antibodies in human, mouse, rat for CSAD
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CSAD gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4