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Aliases for CSAD Gene

Aliases for CSAD Gene

  • Cysteine Sulfinic Acid Decarboxylase 2 3
  • P-Selectin Cytoplasmic Tail-Associated Protein 2 3
  • Cysteine-Sulfinate Decarboxylase 3 4
  • Sulfinoalanine Decarboxylase 3 4
  • EC 4.1.1.29 4 63
  • CSD 3 4
  • Cysteine Sulfinic Acid Decarboxylase-Related Protein 3
  • EC 4.1.1 63
  • PCAP 3

External Ids for CSAD Gene

Summaries for CSAD Gene

Entrez Gene Summary for CSAD Gene

  • This gene encodes a member of the group 2 decarboxylase family. A similar protein in rodents plays a role in multiple biological processes as the rate-limiting enzyme in taurine biosynthesis, catalyzing the decarboxylation of cysteinesulfinate to hypotaurine. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

GeneCards Summary for CSAD Gene

CSAD (Cysteine Sulfinic Acid Decarboxylase) is a Protein Coding gene. Diseases associated with CSAD include disuse amblyopia and amblyopia. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include pyridoxal phosphate binding and sulfinoalanine decarboxylase activity. An important paralog of this gene is DDC.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSAD Gene

Genomics for CSAD Gene

Genomic Location for CSAD Gene

Start:
53,157,663 bp from pter
End:
53,181,630 bp from pter
Size:
23,968 bases
Orientation:
Minus strand

Genomic View for CSAD Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CSAD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSAD Gene

Regulatory Elements for CSAD Gene

Proteins for CSAD Gene

  • Protein details for CSAD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y600-CSAD_HUMAN
    Recommended name:
    Cysteine sulfinic acid decarboxylase
    Protein Accession:
    Q9Y600
    Secondary Accessions:
    • A8K0U4
    • Q4QQH9
    • Q9UNJ5
    • Q9Y601

    Protein attributes for CSAD Gene

    Size:
    493 amino acids
    Molecular mass:
    55023 Da
    Cofactor:
    Name=pyridoxal 5-phosphate; Xref=ChEBI:CHEBI:597326;
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=AAD32546.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH98278.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH98342.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH99717.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI05919.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CSAD Gene

    Alternative splice isoforms for CSAD Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CSAD Gene

Proteomics data for CSAD Gene at MOPED

Selected DME Specific Peptides for CSAD Gene

Post-translational modifications for CSAD Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains for CSAD Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y600

UniProtKB/Swiss-Prot:

CSAD_HUMAN
Family:
  • Belongs to the group II decarboxylase family.:
    • Q9Y600
genes like me logo Genes that share domains with CSAD: view

No data available for Gene Families for CSAD Gene

Function for CSAD Gene

Molecular function for CSAD Gene

UniProtKB/Swiss-Prot CatalyticActivity: 3-sulfino-L-alanine = hypotaurine + CO(2)

Enzyme Numbers (IUBMB) for CSAD Gene

Gene Ontology (GO) - Molecular Function for CSAD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004782 sulfinoalanine decarboxylase activity IEA --
GO:0016829 lyase activity --
GO:0016831 carboxy-lyase activity --
GO:0030170 pyridoxal phosphate binding IEA --
genes like me logo Genes that share ontologies with CSAD: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CSAD Gene

Localization for CSAD Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CSAD Gene COMPARTMENTS Subcellular localization image for CSAD gene
Compartment Confidence
endoplasmic reticulum 2
extracellular 2
mitochondrion 2
cytosol 1
lysosome 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CSAD Gene

Pathways for CSAD Gene

genes like me logo Genes that share pathways with CSAD: view

Pathways by source for CSAD Gene

UniProtKB/Swiss-Prot Q9Y600-CSAD_HUMAN

  • Pathway: Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 2/2

Interacting Proteins for CSAD Gene

Gene Ontology (GO) - Biological Process for CSAD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000096 sulfur amino acid metabolic process TAS --
GO:0000098 sulfur amino acid catabolic process TAS --
GO:0006520 cellular amino acid metabolic process --
GO:0008152 metabolic process --
GO:0019752 carboxylic acid metabolic process --
genes like me logo Genes that share ontologies with CSAD: view

Compounds for CSAD Gene

(8) HMDB Compounds for CSAD Gene

Compound Synonyms Cas Number PubMed IDs
3-Sulfinoalanine
  • 3-Sulphino-L-alanine
1115-65-7
5-L-Glutamyl-taurine
  • 5-Glutamyl-taurine
Not Available
Carbon dioxide
  • Carbon oxide
124-38-9
Cysteic acid
  • 2-Amino-3-sulfopropionate
498-40-8
Hypotaurine
  • 2-Aminoethylsulfinate
300-84-5

(1) Drugbank Compounds for CSAD Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Pyridoxal Phosphate
  • Codecarboxylase
54-47-7 target cofactor

(6) Novoseek inferred chemical compound relationships for CSAD Gene

Compound -log(P) Hits PubMed IDs
cysteine sulfinic acid 98 32
taurine 81 17
hypotaurine 77.3 2
cysteine 48.8 5
glutamate 32.8 4
genes like me logo Genes that share compounds with CSAD: view

Transcripts for CSAD Gene

Unigene Clusters for CSAD Gene

Cysteine sulfinic acid decarboxylase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CSAD Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18
SP1: - - - - - -
SP2: - - -
SP3: - - - -
SP4: - -
SP5: - - -
SP6: -

Relevant External Links for CSAD Gene

GeneLoc Exon Structure for
CSAD
ECgene alternative splicing isoforms for
CSAD

Expression for CSAD Gene

mRNA expression in normal human tissues for CSAD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CSAD Gene

SOURCE GeneReport for Unigene cluster for CSAD Gene Hs.279815

genes like me logo Genes that share expressions with CSAD: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CSAD Gene

Orthologs for CSAD Gene

This gene was present in the common ancestor of animals.

Orthologs for CSAD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CSAD 35
  • 99.62 (n)
  • 99.62 (a)
CSAD 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CSAD 35
  • 89.59 (n)
  • 90.67 (a)
CSAD 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CSAD 35
  • 89.18 (n)
  • 90.47 (a)
CSAD 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Csad 35
  • 88.24 (n)
  • 89.66 (a)
Csad 16
Csad 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CSAD 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CSAD 36
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Csad 35
  • 87.69 (n)
  • 89.66 (a)
chicken
(Gallus gallus)
Aves CSAD 35
  • 72.88 (n)
  • 72.88 (a)
CSAD 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CSAD 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia csad 35
  • 65.76 (n)
  • 67.99 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9083 35
zebrafish
(Danio rerio)
Actinopterygii csad 35
  • 65.12 (n)
  • 64.98 (a)
csad 36
  • 58 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta b 36
  • 45 (a)
ManyToMany
CG5618 36
  • 46 (a)
ManyToMany
Gad1 37
  • 47 (a)
b 37
  • 52 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8535 35
Species with no ortholog for CSAD:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CSAD Gene

ENSEMBL:
Gene Tree for CSAD (if available)
TreeFam:
Gene Tree for CSAD (if available)

Paralogs for CSAD Gene

Paralogs for CSAD Gene

genes like me logo Genes that share paralogs with CSAD: view

Variants for CSAD Gene

Sequence variations from dbSNP and Humsavar for CSAD Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1006959 -- 53,172,652(+) ACCTA(A/G)GAAGA intron-variant
rs1136349 -- 53,177,819(-) ctact(A/G)aaagt intron-variant
rs1136353 -- 53,177,763(-) TTACC(A/G)GGTGG intron-variant
rs1136354 -- 53,177,750(-) gaggc(A/G)ggaga intron-variant
rs1136355 -- 53,177,715(-) GTTGC(A/G)GTGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CSAD Gene

Variant ID Type Subtype PubMed ID
nsv517066 CNV Loss 19592680
nsv470294 CNV Loss 18288195
nsv832417 CNV Gain 17160897
nsv470295 CNV Gain 18288195
nsv713 CNV Insertion 18451855
nsv469404 CNV Loss 19166990
esv2661808 CNV Deletion 23128226

Relevant External Links for CSAD Gene

HapMap Linkage Disequilibrium report
CSAD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSAD Gene

Disorders for CSAD Gene

(3) University of Copenhagen DISEASES for CSAD Gene

(1) Novoseek inferred disease relationships for CSAD Gene

Disease -log(P) Hits PubMed IDs
autoimmune diseases 27.2 2
genes like me logo Genes that share disorders with CSAD: view

No data available for UniProtKB/Swiss-Prot for CSAD Gene

Publications for CSAD Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Cloning of murine cysteine sulfinic acid decarboxylase and its mRNA expression in murine tissues. (PMID: 11997111) Park E. … Schuller-Levis G. (Biochim. Biophys. Acta 2002) 3 23
  4. Analysis of antibody reactivity against cysteine sulfinic acid decarboxylase, a pyridoxal phosphate-dependent enzyme, in endocrine autoimmune disease. (PMID: 15070923) SkAPldberg F. … KAompe O. (J. Clin. Endocrinol. Metab. 2004) 23 25
  5. Cysteine metabolism in periportal and perivenous hepatocytes: perivenous cells have greater capacity for glutathione production and taurine synthesis but not for cysteine catabolism. (PMID: 12436215) Bella D.L. … Stipanuk M.H. (Amino Acids 2002) 23

Products for CSAD Gene

Sources for CSAD Gene

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