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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CSAD Gene

protein-coding GIFtS: 59
GCID: GC12M053551

cysteine sulfinic acid decarboxylase

Explore 7 diseases affiliated with
CSAD via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cysteine Sulfinic Acid Decarboxylase¹ ²		EC 4.1.1.29³ ⁸
CSD¹ ² ³		Cysteine Sulfinic Acid Decarboxylase-Related Protein²
PCAP¹ ²		P-Selectin Cytoplasmic Tail-Associated Protein²
Cysteine-Sulfinate Decarboxylase² ³		EC 4.1.1⁸
Sulfinoalanine Decarboxylase² ³

External Ids:	HGNC: 18966¹	Entrez Gene: 51380²	Ensembl: ENSG00000139631⁷	UniProtKB: Q9Y600³

Export aliases for CSAD gene to outside databases

Previous GC identifers: GC12M053710 GC12M053465 GC12M053268 GC12M051837 GC12M050594

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CSAD:

This gene encodes a member of the group 2 decarboxylase family. A similar protein in rodents plays a role in multiple

biological processes as the rate-limiting enzyme in taurine biosynthesis, catalyzing the decarboxylation of

cysteinesulfinate to hypotaurine. Alternatively spliced transcript variants encoding multiple isoforms have been

observed for this gene. (provided by RefSeq, Sep 2011)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_029419.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CSAD gene promoter:
E2F-4 E2F-3a E2F-5 RP58 E2F-2 Tal-1beta E47 HEN1 E2F-1 E2F
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CSAD promoter sequence

Search SABiosciences Chromatin IP Primers for CSAD

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CSAD

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.11-q14.3 Ensembl cytogenetic band: 12q13.13 HGNC cytogenetic band: 12q13.11-q14.3

CSAD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CSAD gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M053551: view genomic region (about GC identifiers)

Start:	53,551,447 bp from pter	End:	53,575,135 bp from pter
Size:	23,689 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CSAD_HUMAN, Q9Y600 (See protein sequence)

Recommended Name: Cysteine sulfinic acid decarboxylase

Size: 493 amino acids; 55023 Da

Cofactor: Pyridoxal phosphate

Subunit: Homodimer

Sequence caution: Sequence=AAD32546.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Sequence=AAH98278.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAH98342.1;

Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAH99717.1; Type=Erroneous initiation;

Note=Translation N-terminally extended; Sequence=AAI05919.1; Type=Erroneous initiation; Note=Translation N-terminally

extended;

1 PDB 3D structure from and Proteopedia for CSAD:

2JIS (3D)

Secondary accessions: A8K0U4 Q4QQH9 Q9UNJ5 Q9Y601

Alternative splicing: 3 isoforms: Q9Y600-1 Q9Y600-2 Q9Y600-3 (No experimental confirmation available. Ref.4 (AAH98342) sequence is in conflict in position: 9:F->S)

Explore the universe of human proteins at neXtProt for CSAD: NX_Q9Y600

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9Y600

4/7 DME Specific Peptides for CSAD (Q9Y600) (see all 7)

YLFQQDK

PGGSISN

HPRFFNQL

VPFLVSAT

CSAD Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001231634.1 NP_001231635.1 NP_057073.4

ENSEMBL proteins:

ENSP00000436800 ENSP00000267085 ENSP00000369179 ENSP00000369175 ENSP00000415485

ENSP00000410648 ENSP00000449373 ENSP00000455618 ENSP00000390269 ENSP00000415314

ENSP00000401078 ENSP00000457264 ENSP00000369172 ENSP00000439419

Reactome Protein details: Q9Y600
Human Recombinant Protein Products:

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	Browse recombinant and purified proteins available from Enzo Life Sciences
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	GenScript Custom Purified and Recombinant Proteins Services for CSAD
	Novus Biologicals CSAD Protein Novus Biologicals CSAD Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CSAD

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	--	--

CSAD for ontologies About GeneDecksing

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	Uscn Antibodies for CSAD
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Assay Products for CSAD:

	Browse Kits and Assays available from EMD Millipore
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	Uscn ELISAs and CLIAs for CSAD

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CSAD for domains About GeneDecksing

4 InterPro domains/families:

IPR002129 PyrdxlP-dep_de-COase

IPR015422 PyrdxlP-dep_Trfase_major_sub2

IPR015424 PyrdxlP-dep_Trfase

IPR015421 PyrdxlP-dep_Trfase_major_sub1

Graphical View of Domain Structure for InterPro Entry Q9Y600

ProtoNet protein and cluster: Q9Y600

UniProtKB/Swiss-Prot: CSAD_HUMAN, Q9Y600

Similarity: Belongs to the group II decarboxylase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CSAD_HUMAN, Q9Y600

Catalytic activity: 3-sulfino-L-alanine = hypotaurine + CO(2)

Enzyme Numbers (IUBMB): EC 4.1.1.29¹ ² EC 4.1.1²

miRNA Products:		OriGene 3'-UTR Clone: CSAD Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CSAD
		8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate CSAD (see all 13):
		hsa-miR-3685 hsa-miR-30c hsa-miR-3924 hsa-miR-30d hsa-miR-664 hsa-miR-337-3p hsa-miR-1305 hsa-miR-30a

		SwitchGear 3'UTR luciferase reporter plasmid: CSAD 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CSAD (see all 7) OriGene shRNA RFP: CSAD OriGene siRNA: CSAD
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Gene Editing
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DNA2.0 Custom Protein Engineering Service for CSAD

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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CSAD
		Search LifeMap BioReagents cell lines for CSAD

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSAD

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004782	sulfinoalanine decarboxylase activity	IEA	--
GO:0016831	carboxy-lyase activity	--	--
GO:0030170	pyridoxal phosphate binding	IEA	--

CSAD for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Metabolism

Metabolism

1.00

Metabolic pathways

0.38

Beta-alanine metabolism

Beta-alanine metabolism

1.00

Beta-alanine metabolism

0.90

Metabolism of amino acids and derivatives

Metabolism of amino acids and derivatives

1.00

Sulfur amino acid metabolism

Sulfur amino acid metabolism

1.00

Degradation of cysteine and homocysteine

Degradation of cysteine and homocysteine

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for CSAD

Beta-alanine metabolism

1 GeneGo (Thomson Reuters) Pathway for CSAD

Beta-alanine metabolism

1 BioSystems Pathway for CSAD

taurine biosynthesis

4 Reactome Pathways for CSAD

	Metabolism
	Sulfur amino acid metabolism
	Degradation of cysteine and homocysteine
	Metabolism of amino acids and derivatives

2 Kegg Pathways (Kegg details for CSAD):

	Taurine and hypotaurine metabolism
	Metabolic pathways

UniProtKB/Swiss-Prot: CSAD_HUMAN, Q9Y600

Pathway: Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 2/2

CSAD for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CSAD

STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

5/21 Interacting proteins for CSAD (Q9Y600^{2, 3} ENSP00000267085⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 21)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SMN1	Q16637²^,³	MINT-8271025 I2D: score=2
SMN2	Q16637²^,³	MINT-8271025 I2D: score=2
ANXA1	P04083²^,³	MINT-8247775 I2D: score=2
ANXA7	P20073²^,³	MINT-8248230 I2D: score=2
CDKN1A	P38936²^,³	MINT-8251760 I2D: score=2

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000096	sulfur amino acid metabolic process	TAS	--
GO:0000098	sulfur amino acid catabolic process	TAS	--
GO:0019752	carboxylic acid metabolic process	--	--
GO:0034641	cellular nitrogen compound metabolic process	TAS	--
GO:0042412	taurine biosynthetic process	IEA	--

CSAD for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CSAD for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CSAD

8 HMDB Compounds for CSAD About this table

Compound	Synonyms	CAS #	PubMed Ids
3-Sulfinoalanine	3-Sulphino-L-alanine (see all 9)	1115-65-7	--
5-L-Glutamyl-taurine	5-Glutamyl-taurine	--	--
Carbon dioxide	Carbon oxide (see all 5)	124-38-9	--
Cysteic acid	2-Amino-3-sulfopropionate (see all 19)	498-40-8	--
Hypotaurine	2-Aminoethylsulfinate (see all 9)	300-84-5	--
L-Cysteine	(+)-2-Amino-3-mercaptopropionic acid (see all 37)	52-90-4	--
Pyridoxal 5'-phosphate	Apolon B6 (see all 27)	54-47-7	--
Taurine	1-Aminoethane-2-sulfonate (see all 14)	107-35-7	--

1 DrugBank Compound for CSAD About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Pyridoxal Phosphate	Codecarboxylase (see all 9)	54-47-7	target	cofactor	17139284 17016423 15070923

6 Novoseek chemical compound relationships for CSAD gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cysteine sulfinic acid	98	51	8740442 (5), 11455199 (3), 12436215 (3), 8912862 (2) (see all 21)
taurine	81	38	8740442 (3), 10936171 (2), 9635049 (2), 12905652 (2) (see all 12)
hypotaurine	77.3	3	8740442 (2)
cysteine	48.8	9	14992268 (1), 10936171 (1), 11008216 (1), 12436215 (1) (see all 5)
glutamate	32.8	7	11455199 (2), 8912862 (1), 9635049 (1)
nitric oxide	0	2	11455199 (2)

Search CenterWatch for drugs/clinical trials and news about CSAD

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CSAD gene (3 alternative transcripts):

NM_001244705.1 NM_001244706.1 NM_015989.4

Unigene Cluster for CSAD:

Cysteine sulfinic acid decarboxylase

Hs.279815 [show with all ESTs]

Unigene Representative Sequence: NM_015989

18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):

ENST00000475890(uc021qyd.1) ENST00000267085(uc009zmt.3 uc010snx.2 uc001sby.3 uc001sbz.3)

ENST00000379850 ENST00000379846 ENST00000444623 ENST00000453446 ENST00000490923

ENST00000490589 ENST00000485004 ENST00000548698 ENST00000483632 ENST00000472908

ENST00000454442 ENST00000424845 ENST00000437073 ENST00000491654 ENST00000424990

ENST00000498635

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CSAD
		8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate CSAD (see all 13):
		hsa-miR-3685 hsa-miR-30c hsa-miR-3924 hsa-miR-30d hsa-miR-664 hsa-miR-337-3p hsa-miR-1305 hsa-miR-30a

		SwitchGear 3'UTR luciferase reporter plasmid: CSAD 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CSAD (see all 7) OriGene shRNA RFP: CSAD OriGene siRNA: CSAD
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Additional cDNA sequence:

AB044561.1 AF116545.1 AF116546.1 AF116547.1 AF116548.1 AK122681.1 AK289659.1 AK315265.1

BC052249.1 BC098278.1 BC098342.1 BC099717.1 BC105918.1

12 DOTS entries:

DT.99996082 DT.95120528 DT.108407 DT.95180747 DT.75195032 DT.91738127 DT.86857445 DT.91738133

DT.75171452 DT.91986736 DT.100746310 DT.121208749

24/64 AceView cDNA sequences (see all 64):

AW024777 AI743923 AI807766 BF223281 AW845110 AI022542 BC047466 AI460030

AF116547 AL548656 BG315155 BQ772641 AF116548 AI566429 NM_015989 CF455935

CA428251 CK822518 BG702444 AB044561 AK122681 BQ028782 BP357045 BC018042

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CSAD (see all 6) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8a	·	8b	·	8c	·	8d	^	9a	·	9b	^	10	^	11	^	12	^	13	^	14	^	15a	·	15b	^	16	^	17	^	18
SP1:															-		-		-						-				-		-
SP2:																									-				-		-
SP3:																									-				-		-				-
SP4:																													-		-
SP5:																	-		-						-

ECgene alternative splicing isoforms for CSAD

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CSAD expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

CSAD expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Liver

Liver Lobule

Perivenous Hepatocytes

Liver

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CSAD Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CSAD

SOURCE GeneReport for Unigene cluster: Hs.279815

SABiosciences Custom PCR Arrays for CSAD

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CSAD Browse OriGene validated miRNA SYBR primer pairs
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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CSAD

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for CSAD gene from 4/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CSAD¹	cysteine sulfinic acid decarboxylase	72.88(n) 72.88(a)		426184 XM_423847.3 XP_423847.3
lizard (Anolis carolinensis)	Reptilia	CSAD⁶	--	66(a)	1 ↔ 1	2(70301406-70319798)
zebrafish (Danio rerio)	Actinopterygii	57044657²	--	73.41(n)		57044657
fruit fly (Drosophila melanogaster)	Insecta	b³	aspartate 1-decarboxylase	52(a) (best of 2)		2 34D5 --

ENSEMBL Gene Tree for CSAD (if available)
TreeFam Gene Tree for CSAD (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CSAD gene

DDC² GAD1² HDC² GADL1² GAD2²

7 SIMAP similar genes for CSAD using alignment to 11 protein entries: CSAD_HUMAN (see all proteins):

pcap GADL1 GAD65 GAD2 GAD1 DDC

HDC

CSAD for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs35876916^1,2	C,	--	50593593(+)	`GCTAG-/GATTAT`	3	--	ds500¹		1		CSA	2
rs60842707^1,2	C,F,	--	50593975(+)	`NNNNCC/TGGTTG`	3	--	ds500¹		1		WA	118
rs17749735^1,2	C,	--	50594101(+)	`AAAGAT/CATAAA`	3	--	ut3¹ ese³		3		NA	142
rs74883721^1,2	C,F,	--	50594338(+)	`CTTTGT/CAAACA`	3	--	ut3¹		1		WA	118
rs113238124^1,2		--	50594767(+)	`ACAGGC/TGTGAG`	3	--	ut3¹		1		CSA	2
rs77874318^1,2		--	50595480(+)	`TTCCAA/CGTAGG`	3	--	int¹		0	--	--	--	--
rs7969735^1,2	C,F,H,	--	50596397(+)	`AATCCC/TGGGAG`	3	--	int¹		10		NS EA NA WA	1212
rs75777049^1,2	F,	--	50596764(+)	`TACCCT/CCTTCT`	3	--	int¹		1		WA	118
rs2272306^1,2	C,F,H,	--	50596851(+)	`CCCAGG/AGTTCT`	3	--	int¹		20		EA NS NA	4140
rs113980084^1,2		--	50596951(+)	`CACTGG/CGGGAG`	3	--	int¹		2		CSA WA	120

HapMap Linkage Disequilibrium report for CSAD (53551447 - 53575135 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 8 variations for CSAD
8 CNVs: 49091 49090 49096 49094 49089 49095 49092 49093

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CSAD for disorders About GeneDecksing

7 diseases for CSAD: About MalaCards

disuse ambylopia stiff-person syndrome pulmonary edema respiratory failure

hepatocellular carcinoma seizures carcinoma

3 diseases from the University of Copenhagen DISEASES database for CSAD:

Disuse amblyopia Prostate cancer Respiratory failure

1 Novoseek disease relationship for CSAD gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
autoimmune diseases	27.2	3	15070923 (2)

Export disorders for CSAD gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CSAD gene, integrated from 9 sources (see all 30):
(articles sorted by number of sources associating them with CSAD)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2, 3} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Cloning of murine cysteine sulfinic acid decarboxylase and its mRNA expression in murine tissues. (PubMed id 11997111)^{1, 9} Park E....Schuller-Levis G. (2002)
Analysis of antibody reactivity against cysteine sulfinic acid decarboxylase, a pyridoxal phosphate-dependent enzyme, in endocrine autoimmune disease. (PubMed id 15070923)^{7, 9} Skoldberg F....Kampe O. (2004)
A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)¹ Vinayagam A....Wanker E.E. (2011)
Drugs, their targets and the nature and number of dru g targets. (PubMed id 17016423)⁷ Imming P....Meyer A. (2006)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
How many drug targets are there? (PubMed id 17139284)⁷ Overington J.P....Hopkins A.L. (2006)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver. (PubMed id 11752456)¹ Xu X.R.... Han Z.G. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 51380	HGNC: 18966	AceView: CSAD	Ensembl:ENSG00000139631	euGenes: HUgn51380
ECgene: CSAD	Kegg: 51380	H-InvDB: CSAD

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CSAD	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CSAD	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for CSAD gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CSAD gene:
Search GeneIP for patents involving CSAD

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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cysteine sulfinic acid decarboxylase

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