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Aliases for CS Gene

Aliases for CS Gene

  • Citrate Synthase 2 3
  • EC 2.3.3.1 4 63
  • Citrate (Si)-Synthase 4
  • EC 2.3.3 63

External Ids for CS Gene

Previous GeneCards Identifiers for CS Gene

  • GC12M056540
  • GC12P056603
  • GC12M056382
  • GC12M054951
  • GC12M056666
  • GC12M053704

Summaries for CS Gene

Entrez Gene Summary for CS Gene

  • The protein encoded by this gene is a Krebs tricarboxylic acid cycle enzyme that catalyzes the synthesis of citrate from oxaloacetate and acetyl coenzyme A. The enzyme is found in nearly all cells capable of oxidative metablism. This protein is nuclear encoded and transported into the mitochondrial matrix, where the mature form is found. [provided by RefSeq, Jul 2008]

GeneCards Summary for CS Gene

CS (Citrate Synthase) is a Protein Coding gene. Diseases associated with CS include critical illness polyneuropathy and mitochondrial cardiomyopathy. Among its related pathways are Metabolism and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include citrate (Si)-synthase activity.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CS Gene

Genomics for CS Gene

Regulatory Elements for CS Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CS Gene

Start:
56,271,699 bp from pter
End:
56,300,392 bp from pter
Size:
28,694 bases
Orientation:
Minus strand

Genomic View for CS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CS Gene

Proteins for CS Gene

  • Protein details for CS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75390-CISY_HUMAN
    Recommended name:
    Citrate synthase, mitochondrial
    Protein Accession:
    O75390
    Secondary Accessions:
    • Q71UT9
    • Q7KZH0
    • Q96FZ8
    • Q9BWN8

    Protein attributes for CS Gene

    Size:
    466 amino acids
    Molecular mass:
    51712 Da
    Quaternary structure:
    • Homodimer.
    Miscellaneous:
    • Citrate synthase is found in nearly all cells capable of oxidative metabolism
    SequenceCaution:
    • Sequence=CAE45911.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

neXtProt entry for CS Gene

Proteomics data for CS Gene at MOPED

Post-translational modifications for CS Gene

  • Ubiquitination at Lys43, Lys103, Lys327, Lys382, and Lys459
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CS (CS)

Domains for CS Gene

Suggested Antigen Peptide Sequences for CS Gene

Graphical View of Domain Structure for InterPro Entry

O75390

UniProtKB/Swiss-Prot:

CISY_HUMAN :
  • O75390
Family:
  • Belongs to the citrate synthase family.
genes like me logo Genes that share domains with CS: view

No data available for Gene Families for CS Gene

Function for CS Gene

Molecular function for CS Gene

GENATLAS Biochemistry: citrate synthase,mitochondrial,catalyzing the first step of citric acid cycle
UniProtKB/Swiss-Prot CatalyticActivity: Acetyl-CoA + H(2)O + oxaloacetate = citrate + CoA.

Enzyme Numbers (IUBMB) for CS Gene

Gene Ontology (GO) - Molecular Function for CS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004108 citrate (Si)-synthase activity TAS --
GO:0044822 poly(A) RNA binding IDA 22681889
GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer --
genes like me logo Genes that share ontologies with CS: view

Phenotypes for CS Gene

MGI mutant phenotypes for CS:
inferred from 1 alleles
GenomeRNAi human phenotypes for CS:
genes like me logo Genes that share phenotypes with CS: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for CS Gene

Localization for CS Gene

Subcellular locations from UniProtKB/Swiss-Prot for CS Gene

Mitochondrion matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CS Gene COMPARTMENTS Subcellular localization image for CS gene
Compartment Confidence
mitochondrion 5
cytoskeleton 2
cytosol 2
endoplasmic reticulum 2
nucleus 2
peroxisome 2
plasma membrane 2
extracellular 1

Gene Ontology (GO) - Cellular Components for CS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005739 mitochondrion IDA --
GO:0005759 mitochondrial matrix TAS --
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with CS: view

Pathways for CS Gene

genes like me logo Genes that share pathways with CS: view

PCR Array Products

UniProtKB/Swiss-Prot O75390-CISY_HUMAN

  • Pathway: Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2

Gene Ontology (GO) - Biological Process for CS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IDA 9543345
GO:0006099 tricarboxylic acid cycle TAS --
GO:0044237 cellular metabolic process TAS --
GO:0044262 cellular carbohydrate metabolic process IEA --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with CS: view

Compounds for CS Gene

(5) HMDB Compounds for CS Gene

Compound Synonyms Cas Number PubMed IDs
Acetyl-CoA
  • S-Acetyl coenzyme A
72-89-9
Citric acid
  • 2-Hydroxy-1,2,3-propanetricarboxylate
77-92-9
Coenzyme A
  • Acetoacetyl coenzyme A sodium salt
85-61-0
Oxalacetic acid
  • 2-Ketosuccinate
328-42-7
Water
  • Dihydrogen oxide
7732-18-5

(7) Drugbank Compounds for CS Gene

(76) Novoseek inferred chemical compound relationships for CS Gene

Compound -log(P) Hits PubMed IDs
citrate 97.7 257
succinate 77.9 44
malate 77.6 39
oxaloacetate 76.4 17
lactate 72.6 85
genes like me logo Genes that share compounds with CS: view

Transcripts for CS Gene

Unigene Clusters for CS Gene

Citrate synthase:
Representative Sequences:

Inhibitory RNA Products

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CS Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ·
SP1: - - - - - - -
SP2: - - -
SP3: - - - - - -
SP4:
SP5: - - - - - -
SP6: - - - - - - - -
SP7: - -
SP8: - - - - - - - - - - -
SP9: - - - - - -
SP10: - - - - - - - - - - -
SP11: - - - - - - - - - - - -
SP12: - - - - - - - - - - - - - -
SP13: - - - -
SP14: -
SP15: - - - -

ExUns: 13c ^ 14 ^ 15 ^ 16 ^ 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for CS Gene

GeneLoc Exon Structure for
CS
ECgene alternative splicing isoforms for
CS

Expression for CS Gene

mRNA expression in normal human tissues for CS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CS Gene

This gene is overexpressed in Heart - Left Ventricle (4.6) and Muscle - Skeletal (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CS Gene

SOURCE GeneReport for Unigene cluster for CS Gene Hs.743252

genes like me logo Genes that share expressions with CS: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CS Gene

Orthologs for CS Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CS 35
  • 99.57 (n)
  • 99.79 (a)
cow
(Bos Taurus)
Mammalia CS 35
  • 92.92 (n)
  • 95.71 (a)
CS 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CS 35
  • 93.28 (n)
  • 96.78 (a)
CS 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cs 35
  • 88.74 (n)
  • 94.48 (a)
Cs 16
Cs 36
  • 94 (a)
OneToMany
Csl 36
  • 90 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 90 (a)
OneToMany
-- 36
  • 93 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Cs 35
  • 89.45 (n)
  • 94.51 (a)
chicken
(Gallus gallus)
Aves CS 35
  • 77.78 (n)
  • 92.04 (a)
CS 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CS 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cs 35
  • 77.83 (n)
  • 90.53 (a)
Str.1513 35
zebrafish
(Danio rerio)
Actinopterygii cs 36
  • 88 (a)
OneToOne
LOC100536541 35
  • 77.19 (n)
  • 89.4 (a)
wufb58e04 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012048 35
  • 67.56 (n)
  • 74.55 (a)
fruit fly
(Drosophila melanogaster)
Insecta kdn 35
  • 66.29 (n)
  • 73.29 (a)
kdn 36
  • 62 (a)
OneToOne
CG3861 37
  • 73 (a)
CG14740 37
  • 54 (a)
worm
(Caenorhabditis elegans)
Secernentea cts-1 35
  • 61.78 (n)
  • 69.53 (a)
cts-1 36
  • 67 (a)
OneToOne
T20G5.2 37
  • 68 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CIT1 38
CIT2 35
  • 57.67 (n)
  • 60.41 (a)
CIT2 36
  • 58 (a)
OneToOne
soybean
(Glycine max)
eudicotyledons Gma.16706 35
thale cress
(Arabidopsis thaliana)
eudicotyledons ATCS 35
  • 61.71 (n)
  • 62.79 (a)
rice
(Oryza sativa)
Liliopsida Os02g0194100 35
  • 60.47 (n)
  • 62.56 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5369 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 70 (a)
OneToOne
Species with no ortholog for CS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CS Gene

ENSEMBL:
Gene Tree for CS (if available)
TreeFam:
Gene Tree for CS (if available)

Paralogs for CS Gene

genes like me logo Genes that share paralogs with CS: view

No data available for Paralogs for CS Gene

Variants for CS Gene

Sequence variations from dbSNP and Humsavar for CS Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs703831 -- 56,291,128(+) taaaa(C/T)aattt intron-variant
rs744050 -- 56,273,602(-) CACAG(G/T)GGGGT missense, reference
rs744051 -- 56,273,514(-) AGTCA(A/G)TTAAC intron-variant
rs773652 -- 56,280,982(+) AGTTG(A/G)TGCCA intron-variant
rs773653 -- 56,283,266(+) tgaga(C/T)ggagt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CS Gene

Variant ID Type Subtype PubMed ID
nsv482992 CNV Complex 15286789

Relevant External Links for CS Gene

HapMap Linkage Disequilibrium report
CS
Human Gene Mutation Database (HGMD)
CS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CS Gene

Disorders for CS Gene

(6) University of Copenhagen DISEASES for CS Gene

(27) Novoseek inferred disease relationships for CS Gene

Disease -log(P) Hits PubMed IDs
mitochondrial diseases 58.6 3
insulin sensitivity 46.3 3
myopathy 44.8 1
insulin resistance 37 2
shock 36.8 9

Relevant External Links for CS

Genetic Association Database (GAD)
CS
Human Genome Epidemiology (HuGE) Navigator
CS
genes like me logo Genes that share disorders with CS: view

No data available for UniProtKB/Swiss-Prot for CS Gene

Publications for CS Gene

  1. Cloning and tissue expression pattern analysis of the human citrate synthase cDNA. (PMID: 12549038) Liu Q. … Zhao S.Y. (Shi Yan Sheng Wu Xue Bao 2000) 3 4 23
  2. Single nucleotide polymorphisms in succinate dehydrogenase subunits and citrate synthase genes: association results for impaired spermatogenesis. (PMID: 17298551) Bonache S. … Larriba S. (Int. J. Androl. 2007) 3 23 48
  3. Enhanced citrate synthase activity in human pancreatic cancer. (PMID: 15714131) Schlichtholz B. … Swierczynski J. (Pancreas 2005) 3 23
  4. Interactive domains for chaperone activity in the small heat shock protein, human alphaB crystallin. (PMID: 16274233) Ghosh J.G. … Clark J.I. (Biochemistry 2005) 3 23
  5. Identification and characterization of the mitochondrial targeting sequence and mechanism in human citrate synthase. (PMID: 19479947) Cheng T.L. … Chang W.T. (J. Cell. Biochem. 2009) 3 23

Products for CS Gene

Sources for CS Gene

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