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CRYZL1 Gene

protein-coding   GIFtS: 50
GCID: GC21M034961

Crystallin, Zeta (Quinone Reductase)-Like 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
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Aliases
Crystallin, Zeta (Quinone Reductase)-Like 11 2     4P112 3
Quinone Reductase-Like 11 2     QOH-12 3
Protein 4P112 3     Human Quinone Oxidoreductase Homolog-111
Quinone Oxidoreductase Homolog 12 3     Quinone Oxidoreductase-Like Protein 12
Zeta-Crystallin Homolog2 3     EC 1.-.-.-3

External Ids:    HGNC: 24201   Entrez Gene: 99462   Ensembl: ENSG000002057587   OMIM: 6039205   UniProtKB: O958253   

Export aliases for CRYZL1 gene to outside databases

Previous GC identifers: GC21M031527 GC21M031609 GC21M033871 GC21M033872 GC21M033882 GC21M020440


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CRYZL1 Gene:
This gene encodes a protein that has sequence similarity to zeta crystallin, also known as quinone oxidoreductase.
This zeta crystallin-like protein also contains an NAD(P)H binding site. Alternatively spliced transcript
variants have been observed but their full-length nature has not been completely determined. (provided by RefSeq,
Jul 2008)

GeneCards Summary for CRYZL1 Gene:
CRYZL1 (crystallin, zeta (quinone reductase)-like 1) is a protein-coding gene. GO annotations related to this gene include NADPH:quinone reductase activity and NADP binding.

Gene Wiki entry for CRYZL1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
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RefSeq DNA sequence at NCBI GenBank:
NC_000021.8  NC_018932.2  NT_011512.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the CRYZL1 gene promoter:
         TBP   p53   FOXO3   FOXD1   STAT5A   Tal-1beta   AREB6   S8   FOXO3a   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCRYZL1 promoter sequence

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CRYZL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q21.3   Ensembl cytogenetic band:  21q22.11   HGNC cytogenetic band: 21q22.1
Nature(405: 311-319) cytogenetic band:   21q22.11
CRYZL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRYZL1 gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21M034961:   GeneLoc Nature:405,311-319
Start:
34,961,647 bp from pter       20,538,571 bp from centromere
End:
35,016,232 bp from pter 20,590,675 bp from centromere
Size:
54,586 bases 52,105 bases
Orientation:
minus strand minus strand

Whole chromosome sequencing:
cDNA sequence: AF029689
genomic clones: pT377 - pT1276


(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: QORL1_HUMAN, O95825 (See protein sequence)
Recommended Name: Quinone oxidoreductase-like protein 1  
Size: 349 amino acids; 38697 Da
Sequence caution: Sequence=AAH13155.1; Type=Miscellaneous discrepancy; Sequence=BAA91605.1; Type=Frameshift;
Positions=302;
Secondary accessions: B2RDX1 Q96DY0 Q9NVY7
Alternative splicing: 2 isoforms:  O95825-1   O95825-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CRYZL1: NX_O95825

Explore proteomics data for CRYZL1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys182
  • Modification sites at PhosphoSitePlus

  • See CRYZL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_665857.2  
    ENSEMBL proteins: 
     ENSP00000370966   ENSP00000290244   ENSP00000370951   ENSP00000413513   ENSP00000397318  
     ENSP00000399730   ENSP00000406423   ENSP00000355075   ENSP00000399937   ENSP00000416315  
     ENSP00000412087   ENSP00000409387   ENSP00000387660   ENSP00000405510   ENSP00000402844  
     ENSP00000389209   ENSP00000408385   ENSP00000382371  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR013149 ADH_C
     IPR011032 GroES-like
     IPR013154 ADH_GroES-like
     IPR002085 ADH_SF_Zn-type
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry O95825

    ProtoNet protein and cluster: O95825

    1 Blocks protein domain: IPB013154 Alcohol dehydrogenase GroES-like

    UniProtKB/Swiss-Prot: QORL1_HUMAN, O95825
    Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily


    Find genes that share domains with CRYZL1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for CRYZL1:
    cristallin zeta (quinone reductase)-like 1,expressed in heart,brain,skeletal muscle

         Enzyme Number (IUBMB): EC 1.-.-.-1

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003960NADPH:quinone reductase activity NAS10191096
    GO:0008270zinc ion binding IEA--
    GO:0016491oxidoreductase activity ----
    GO:0016747transferase activity, transferring acyl groups other than amino-acyl groups ----
    GO:0050661NADP binding NAS10191096
         
    Find genes that share ontologies with CRYZL1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CRYZL1:
     Decreased Salmonella enterica  

         1 MGI phenotypic allele for Cryzl1 (no phenotypes)

    Find genes that share phenotypes with CRYZL1           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CRYZL1
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol IDA16780588

    Find genes that share ontologies with CRYZL1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CRYZL1
    Interactions:

        Search GeneGlobe Interaction Network for CRYZL1

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0055114oxidation-reduction process ----
    GO:1901661quinone metabolic process NAS10191096

    Find genes that share ontologies with CRYZL1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for CRYZL1 (QORL1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CRYZL1 gene (2 alternative transcripts): 
    NM_145858.2  NM_145311.1  

    Unigene Cluster for CRYZL1:

    Crystallin, zeta (quinone reductase)-like 1
    Hs.352671  [show with all ESTs]
    Unigene Representative Sequence: BX648547
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23):
    ENST00000381554 ENST00000290244(uc021wio.1) ENST00000468349 ENST00000381540
    ENST00000452420 ENST00000441940 ENST00000480893 ENST00000445393 ENST00000437996
    ENST00000361534(uc002ysr.1) ENST00000429827 ENST00000420072(uc002yss.1 uc002yst.1)
    ENST00000440526(uc002ysq.3) ENST00000479964 ENST00000414079 ENST00000426935
    ENST00000431177 ENST00000488167
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    SwitchGear 3'UTR luciferase reporter plasmidCRYZL1 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AF029689.1 AF086550.1 AF098798.1 AK001293.1 AK058071.1 AK315707.1 BC013155.1 BC022827.1 
    BC032816.1 BC033023.2 BC039589.1 BX537843.1 BX647276.1 BX648547.1 

    Selected DOTS entries (see all 27):

    DT.442062  DT.92429579  DT.95361382  DT.92040066  DT.100821136  DT.97843821  DT.100821135  DT.100821139 
    DT.121141098  DT.316467  DT.412102  DT.92328721  DT.97819208  DT.100027049  DT.121141197  DT.86994905 
    DT.121141305  DT.442008  DT.92429582  DT.97784331  DT.100821131  DT.101957599  DT.100649559  DT.100663450 

    Selected AceView cDNA sequences (see all 195):

    AI307114 BQ008344 BC022827 BQ925216 AA745747 CB118996 AA603584 AA482381 
    NM_145795 CA312606 CR590888 BF515899 NM_145794 CB306205 BM977319 BX107958 
    BQ233817 AI480262 T95247 AI378838 NM_017613 CA445697 AU142301 BM475483 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CRYZL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CRYZL1 Expression
    About this image


    CRYZL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)
             Diencephalon
     
     Peripheral Nervous System (Nervous System)
     
     Spinal Cord (Nervous System)
    CRYZL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CRYZL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.352671

    UniProtKB/Swiss-Prot: QORL1_HUMAN, O95825
    Tissue specificity: Ubiquitous

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CRYZL1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cryzl11 , 5 crystallin, zeta (quinone reductase)-like 11, 5 88.79(n)1
    90.8(a)1
      16 (53.26 cM)5
    666091  NM_133679.21  NP_598440.11 
     916893225 
    chicken
    (Gallus gallus)
    Aves CRYZL11 crystallin, zeta (quinone reductase)-like 1 78.22(n)
    78.8(a)
      418505  XM_004934522.1  XP_004934579.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    73(a)
    64(a)
    many → 1
    many → 1
    3(142897814-142934524)
    2(130278888-130280816)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.243772 Xenopus laevis transcribed sequence with weak similarity more 76.33(n)    CA971281.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cryzl11 crystallin, zeta (quinone reductase)-like 1 60.95(n)
    61.05(a)
      436906  NM_001002633.1  NP_001002633.1 


    ENSEMBL Gene Tree for CRYZL1 (if available)
    TreeFam Gene Tree for CRYZL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CRYZL1 gene
    1 SIMAP similar gene for CRYZL1 using alignment to 18 protein entries:     QORL1_HUMAN (see all proteins):
    TP53I3

    Find genes that share paralogs with CRYZL1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CRYZL1 (see all 919)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs782287371,2
    C--34963166(+) ATGGAC/GTGAGG 1 -- int10--------
    rs1396627971,2
    --34963252(+) AGCAGA/CTATTT 1 -- int10--------
    rs1841128931,2
    --34963331(+) AATTAC/TGTTTG 1 -- int10--------
    rs1858968351,2
    --34963378(+) CATGGC/TGAGAG 1 -- int10--------
    rs1911421181,2
    C--34963418(+) GCTCCC/TTGAAA 1 -- int10--------
    rs1448845961,2
    C--34963513(+) AGATAC/TGTAGC 2 Y C mis11Minor allele frequency- T:0.00NA 4552
    rs746639631,2
    C--34963585(+) GGATGC/TCAGGC 1 -- int10--------
    rs1167402731,2
    C,F--34963638(+) CAACAT/CGTTAA 1 -- int11Minor allele frequency- C:0.03WA 118
    rs1445801471,2
    C--34963665(+) AGGACG/TTCAAG 1 -- int10--------
    rs1396698801,2
    --34963763(+) AAGCCG/TGGTGC 1 -- int10--------

    HapMap Linkage Disequilibrium report for CRYZL1 (34961647 - 35016232 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CRYZL1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv913724CNV Loss21882294

    Human Gene Mutation Database (HGMD): CRYZL1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603920    OMIM disorders: --


    Find genes that share disorders with CRYZL1           About GenesLikeMe


    Export disorders for CRYZL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CRYZL1 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with CRYZL1)
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    1. Identification of a zeta-crystallin (quinone reductase)-like 1 gene (CRYZL1) mapped to human chromosome 21q22.1. (PubMed id 10191096)1, 2, 3, 9 Kim M.-Y.... Soh J. (Genomics 1999)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    6. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    8. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    9. Human and yeast zeta-crystallins bind AU-rich elements in RNA. (PubMed id 17497241)1 Fernandez M.R.... Pares X. (Cell. Mol. Life Sci. 2007)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9946 HGNC: 2420 AceView: CRYZL1andDONSON Ensembl:ENSG00000205758 euGenes: HUgn9946
    ECgene: CRYZL1 H-InvDB: CRYZL1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CRYZL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CRYZL1 gene:
    Search GeneIP for patents involving CRYZL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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