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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CRYZL1 Gene

protein-coding GIFtS: 46
GCID: GC21M034961

crystallin, zeta (quinone reductase)-like 1

Explore 1 disease affiliated with
CRYZL1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, and/or ¹¹Nature:405,311-319 and CroW21)
About This Section

Aliases
Crystallin, Zeta (Quinone Reductase)-Like 1¹ ²		Zeta-Crystallin Homolog² ³
4P11¹ ² ³		Human Quinone Oxidoreductase Homolog-111
QOH-1¹ ² ³		Quinone Oxidoreductase-Like Protein 1²
Protein 4P11² ³		Quinone Reductase-Like 1²
Quinone Oxidoreductase Homolog 1² ³		EC 1.-.-.-³

External Ids:	HGNC: 2420¹	Entrez Gene: 9946²	Ensembl: ENSG00000205758⁷	OMIM: 603920⁵	UniProtKB: O95825³

Export aliases for CRYZL1 gene to outside databases

Previous GC identifers: GC21M031527 GC21M031609 GC21M033871 GC21M033872 GC21M033882 GC21M020440

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CRYZL1:

This gene encodes a protein that has sequence similarity to zeta crystallin, also known as quinone oxidoreductase. This

zeta crystallin-like protein also contains an NAD(P)H binding site. Alternatively spliced transcript variants have

been observed but their full-length nature has not been completely determined. (provided by RefSeq, Jul 2008)

Gene Wiki entry for CRYZL1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section

RefSeq DNA sequence:

NC_000021.8 NC_018932.1 NT_011512.11

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CRYZL1 gene promoter:
TBP p53 FOXO3 FOXD1 STAT5A Tal-1beta AREB6 S8 FOXO3a ITF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CRYZL1 promoter sequence

Search SABiosciences Chromatin IP Primers for CRYZL1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CRYZL1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q21.3 Ensembl cytogenetic band: 21q22.11 HGNC cytogenetic band: 21q22.1
Nature(405: 311-319) cytogenetic band: 21q22.11

CRYZL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRYZL1 gene location

GeneLoc information about chromosome 21 GeneLoc Exon Structure

(about GC identifiers)

GC21M034961:	GeneLoc	Nature:405,311-319
Start:	34,961,647 bp from pter	20,538,571 bp from centromere
End:	35,016,232 bp from pter	20,590,675 bp from centromere
Size:	54,586 bases	52,105 bases
Orientation:	minus strand	minus strand

Whole chromosome sequencing:
cDNA sequence:	AF029689
genomic clones:	pT377 - pT1276

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: QORL1_HUMAN, O95825 (See protein sequence)

Recommended Name: Quinone oxidoreductase-like protein 1

Size: 349 amino acids; 38697 Da

Sequence caution: Sequence=AAH13155.1; Type=Miscellaneous discrepancy; Sequence=BAA91605.1; Type=Frameshift;

Positions=302;

Secondary accessions: B2RDX1 Q96DY0 Q9NVY7

Alternative splicing: 2 isoforms: O95825-1 O95825-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CRYZL1: NX_O95825

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O95825

CRYZL1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_665857.2

ENSEMBL proteins:

ENSP00000370966 ENSP00000290244 ENSP00000370951 ENSP00000413513 ENSP00000397318

ENSP00000399730 ENSP00000406423 ENSP00000355075 ENSP00000399937 ENSP00000416315

ENSP00000412087 ENSP00000409387 ENSP00000387660 ENSP00000405510 ENSP00000402844

ENSP00000389209 ENSP00000408385 ENSP00000382371

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	Browse Proteins at Uscn

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	IDA	16780588

CRYZL1 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CRYZL1 for domains About GeneDecksing

5 InterPro domains/families:

IPR013149 ADH_C

IPR011032 GroES-like

IPR013154 ADH_GroES-like

IPR002085 ADH_SF_Zn-type

IPR016040 NAD(P)-bd_dom

Graphical View of Domain Structure for InterPro Entry O95825

ProtoNet protein and cluster: O95825

1 Blocks protein family: IPB013154 Alcohol dehydrogenase GroES-like

UniProtKB/Swiss-Prot: QORL1_HUMAN, O95825

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

Genatlas biochemistry entry for CRYZL1:

cristallin zeta (quinone reductase)-like 1,expressed in heart,brain,skeletal muscle

Enzyme Number (IUBMB): EC 1.-.-.-¹

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In Situ Assay
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Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	--	--
GO:0003960	NADPH:quinone reductase activity	NAS	10191096
GO:0008270	zinc ion binding	IEA	--
GO:0016491	oxidoreductase activity	--	--
GO:0050661	NADP binding	NAS	10191096

CRYZL1 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for CRYZL1:

Decreased Salmonella enterica

Animal Models:
1 MGI phenotypic allele

for Cryzl1 (no phenotypes)

CRYZL1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CRYZL1

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0042375	quinone cofactor metabolic process	NAS	10191096

CRYZL1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CRYZL1
Search CenterWatch for drugs/clinical trials and news about CRYZL1 / QORL1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CRYZL1 gene (2 alternative transcripts):

NM_145858.2 NM_145311.1

Unigene Cluster for CRYZL1:

Crystallin, zeta (quinone reductase)-like 1

Hs.352671 [show with all ESTs]

Unigene Representative Sequence: BX648547

18/23 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23):

ENST00000381554 ENST00000290244(uc021wio.1) ENST00000468349 ENST00000381540

ENST00000452420 ENST00000441940 ENST00000480893 ENST00000445393 ENST00000437996

ENST00000361534(uc002ysr.1) ENST00000429827 ENST00000420072(uc002yss.1 uc002yst.1)

ENST00000440526(uc002ysq.3) ENST00000479964 ENST00000414079 ENST00000426935

ENST00000431177 ENST00000488167

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		hsa-miR-3671 hsa-miR-141* hsa-miR-607
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Additional cDNA sequence:

AF029689.1 AF086550.1 AF098798.1 AK001293.1 AK058071.1 AK315707.1 BC013155.1 BC022827.1

BC032816.1 BC033023.2 BC039589.1 BX537843.1 BX647276.1 BX648547.1

24/27 DOTS entries (see all 27):

DT.442062 DT.92429579 DT.95361382 DT.92040066 DT.100821136 DT.97843821 DT.100821135 DT.100821139

DT.121141098 DT.316467 DT.412102 DT.92328721 DT.97819208 DT.100027049 DT.121141197 DT.86994905

DT.121141305 DT.442008 DT.92429582 DT.97784331 DT.100821131 DT.101957599 DT.100649559 DT.100663450

24/195 AceView cDNA sequences (see all 195):

AI470167 BC048266 CA445697 BF515899 CB306205 CB164606 AA745747 BM669620

AI480262 NM_145795 BM475483 AI378838 CR598801 NM_145794 BM698837 BF035296

BX100188 AI827732 AI025162 CB139666 NM_017613 CB118996 BQ014362 AA769488

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CRYZL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image
See CRYZL1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CRYZL1

SOURCE GeneReport for Unigene cluster: Hs.352671

UniProtKB/Swiss-Prot: QORL1_HUMAN, O95825

Tissue specificity: Ubiquitous

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CRYZL1 gene from 5/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Cryzl1^{1 , 5}	crystallin, zeta (quinone reductase)-like 1^{1, 5}	88.79(n)¹ 90.8(a)¹		16 (53.26 cM)⁵ 66609¹ NM_133679.2¹ NP_598440.1¹ 91689322⁵
chicken (Gallus gallus)	Aves	CRYZL1¹	crystallin, zeta (quinone reductase)-like 1	78.22(n) 78.8(a)		418505 XM_416714.3 XP_416714.3
lizard (Anolis carolinensis)	Reptilia	-- --	--	72(a) 64(a)	many → 1 many → 1	3(142897813-142933046) 2(130278888-130280816)
African clawed frog (Xenopus laevis)	Amphibia	Xl.24377²	Xenopus laevis transcribed sequence with weak similarity more	76.33(n)		CA971281.1
zebrafish (Danio rerio)	Actinopterygii	cryzl1¹	crystallin, zeta (quinone reductase)-like 1	60.84(n) 60.93(a)		436906 NM_001002633.1 NP_001002633.1

ENSEMBL Gene Tree for CRYZL1 (if available)
TreeFam Gene Tree for CRYZL1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 21 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs76066544^1,2	F,	--	34961377(+)	`CGATGG/TGCTGC`	2	--	us2k¹ ds500¹		1		WA	118
rs147027333^1,2		--	34961666(+)	`GGCTAA/GGTCTT`	2	--	ut3¹ us2k¹		0	--	--	--	--
rs138347072^1,2		--	34961698(+)	`AAATGC/TTTAAA`	2	--	ut3¹ us2k¹		0	--	--	--	--
rs149212983^1,2		--	34961809(+)	`AAGAGC/TAGTGT`	2	--	us2k¹ ut3¹		0	--	--	--	--
rs188922485^1,2		--	34961875(+)	`AAATAC/TATAGA`	2	--	ut3¹ us2k¹		0	--	--	--	--
rs143362717^1,2		--	34961909(+)	`AATTCC/TCTTAA`	2	--	ut3¹ us2k¹		0	--	--	--	--
rs1046312^1,2	C,F,A,H,	--	34961965(-)	`AAAAGT/AGTTTG`	2	--	us2k¹ ut3¹		10		MN NS EA NA CSA WA	958
rs3761349^1,2	C,F,H	--	34961966(+)	`AAACAC/TTTTTC`	2	--	ut3¹ us2k¹ ese³		5		EA NS NA	520
rs148353071^1,2		--	34962010(+)	`GAAACA/GTGCTT`	2	--	ut3¹ us2k¹		0	--	--	--	--
rs181673515^1,2	C,	--	34962134(+)	`TAAAAC/TTGAAC`	3	Q	us2k¹ syn¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CRYZL1 (34961647 - 35016232 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CRYZL1: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CRYZL1 for disorders           About GeneDecksing

OMIM gene information: 603920    OMIM disorders: --

1 disease for CRYZL1:    About MalaCards

alcoholism

Export disorders for CRYZL1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CRYZL1 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with CRYZL1)

Utopia: connect your pdf to the dynamic
world of online information

Identification of a zeta-crystallin (quinone reductase)-like 1 gene (CRYZL1) mapped to human chromosome 21q22.1. (PubMed id 10191096)^{1, 2, 3, 9} Kim M.-Y.... Soh J. (1999)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)¹ Woods N.T....Monteiro A.N. (2012)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
Human and yeast zeta-crystallins bind AU-rich elements in RNA. (PubMed id 17497241)¹ Fernandez M.R.... Pares X. (2007)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins. (PubMed id 16780588)¹ Hu Y.H....Janitz M. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 9946	HGNC: 2420	AceView: CRYZL1andDONSON	Ensembl:ENSG00000205758	euGenes: HUgn9946
ECgene: CRYZL1	H-InvDB: CRYZL1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CRYZL1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CRYZL1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CRYZL1 gene:
Search GeneIP for patents involving CRYZL1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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CRYZL1 Gene

crystallin, zeta (quinone reductase)-like 1

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CRYZL1 Gene

crystallin, zeta (quinone reductase)-like 1

Aliasesfor CRYZL1 gene

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Aliases
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for CRYZL1 gene

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for CRYZL1 gene

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for CRYZL1 gene

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Families
for CRYZL1 gene

Function
for CRYZL1 gene

Pathways & Interactions
for CRYZL1 gene

Drugs & Compounds
for CRYZL1 gene

Transcripts
for CRYZL1 gene

Expression
for CRYZL1 gene

Orthologs
for CRYZL1 gene

Paralogs
for CRYZL1 gene

Genomic Variants
for CRYZL1 gene

Disorders / Diseases
for CRYZL1 gene

Publications
for CRYZL1 gene

Intellectual Property
for CRYZL1 gene

Products
for CRYZL1 gene