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Aliases for CRYZL1 Gene

Aliases for CRYZL1 Gene

  • Crystallin, Zeta (Quinone Reductase)-Like 1 2 3
  • Quinone Oxidoreductase Homolog 1 3 4
  • Quinone Reductase-Like 1 2 3
  • Zeta-Crystallin Homolog 3 4
  • Protein 4P11 3 4
  • QOH-1 3 4
  • 4P11 3 4
  • Quinone Oxidoreductase-Like Protein 1 3
  • EC 1.-.-.- 4

External Ids for CRYZL1 Gene

Previous GeneCards Identifiers for CRYZL1 Gene

  • GC21M031527
  • GC21M031609
  • GC21M033871
  • GC21M033872
  • GC21M033882
  • GC21M034961
  • GC21M020440

Summaries for CRYZL1 Gene

Entrez Gene Summary for CRYZL1 Gene

  • This gene encodes a protein that has sequence similarity to zeta crystallin, also known as quinone oxidoreductase. This zeta crystallin-like protein also contains an NAD(P)H binding site. Alternatively spliced transcript variants have been observed but their full-length nature has not been completely determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for CRYZL1 Gene

CRYZL1 (Crystallin, Zeta (Quinone Reductase)-Like 1) is a Protein Coding gene. GO annotations related to this gene include NADP binding and NADPH:quinone reductase activity.

Gene Wiki entry for CRYZL1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRYZL1 Gene

Genomics for CRYZL1 Gene

Regulatory Elements for CRYZL1 Gene

Genomic Location for CRYZL1 Gene

33,589,341 bp from pter
33,643,926 bp from pter
54,586 bases
Minus strand

Genomic View for CRYZL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CRYZL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRYZL1 Gene

Proteins for CRYZL1 Gene

  • Protein details for CRYZL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Quinone oxidoreductase-like protein 1
    Protein Accession:
    Secondary Accessions:
    • B2RDX1
    • B3KQ77
    • Q96DY0
    • Q9NVY7

    Protein attributes for CRYZL1 Gene

    349 amino acids
    Molecular mass:
    38697 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH13155.1; Type=Miscellaneous discrepancy; Evidence={ECO:0000305}; Sequence=BAA91605.1; Type=Frameshift; Positions=302; Evidence={ECO:0000305};

    Alternative splice isoforms for CRYZL1 Gene


neXtProt entry for CRYZL1 Gene

Proteomics data for CRYZL1 Gene at MOPED

Post-translational modifications for CRYZL1 Gene

  • Ubiquitination at Lys182
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CRYZL1 Gene

Domains for CRYZL1 Gene

Protein Domains for CRYZL1 Gene

Graphical View of Domain Structure for InterPro Entry



  • O95825
  • Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
genes like me logo Genes that share domains with CRYZL1: view

No data available for Gene Families for CRYZL1 Gene

Function for CRYZL1 Gene

Molecular function for CRYZL1 Gene

GENATLAS Biochemistry: cristallin zeta (quinone reductase)-like 1,expressed in heart,brain,skeletal muscle

Enzyme Numbers (IUBMB) for CRYZL1 Gene

Gene Ontology (GO) - Molecular Function for CRYZL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003960 NADPH:quinone reductase activity NAS 10191096
GO:0008270 zinc ion binding IEA --
GO:0016491 oxidoreductase activity --
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups --
GO:0050661 NADP binding NAS 10191096
genes like me logo Genes that share ontologies with CRYZL1: view

Phenotypes for CRYZL1 Gene

GenomeRNAi human phenotypes for CRYZL1:
genes like me logo Genes that share phenotypes with CRYZL1: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CRYZL1 Gene

Localization for CRYZL1 Gene

Subcellular locations from

Jensen Localization Image for CRYZL1 Gene COMPARTMENTS Subcellular localization image for CRYZL1 gene
Compartment Confidence
cytosol 5
nucleus 2

Gene Ontology (GO) - Cellular Components for CRYZL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA 16780588
genes like me logo Genes that share ontologies with CRYZL1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CRYZL1 Gene

Pathways for CRYZL1 Gene

SuperPathways for CRYZL1 Gene

No Data Available

Interacting Proteins for CRYZL1 Gene

Gene Ontology (GO) - Biological Process for CRYZL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
GO:1901661 quinone metabolic process NAS 10191096
genes like me logo Genes that share ontologies with CRYZL1: view

No data available for Pathways by source for CRYZL1 Gene

Transcripts for CRYZL1 Gene

Unigene Clusters for CRYZL1 Gene

Crystallin, zeta (quinone reductase)-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CRYZL1 Gene

No ASD Table

Relevant External Links for CRYZL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CRYZL1 Gene

mRNA expression in normal human tissues for CRYZL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CRYZL1 Gene

SOURCE GeneReport for Unigene cluster for CRYZL1 Gene Hs.352671

mRNA Expression by UniProt/SwissProt for CRYZL1 Gene

Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with CRYZL1: view

No data available for mRNA differential expression in normal tissues for CRYZL1 Gene

Orthologs for CRYZL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CRYZL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CRYZL1 35
  • 99.9 (n)
  • 100 (a)
  • 100 (a)
(Bos Taurus)
Mammalia CRYZL1 35
  • 91.79 (n)
  • 94.27 (a)
  • 94 (a)
(Canis familiaris)
Mammalia -- 36
  • 94 (a)
-- 36
  • 94 (a)
LOC100856647 35
  • 92.74 (n)
  • 93.7 (a)
(Mus musculus)
Mammalia Cryzl1 35
  • 88.79 (n)
  • 90.8 (a)
Cryzl1 16
Cryzl1 36
  • 91 (a)
(Monodelphis domestica)
Mammalia CRYZL1 36
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia CRYZL1 36
  • 77 (a)
(Rattus norvegicus)
Mammalia Cryzl1 35
  • 88.22 (n)
  • 89.37 (a)
(Gallus gallus)
Aves CRYZL1 35
  • 78.22 (n)
  • 78.8 (a)
  • 79 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 64 (a)
-- 36
  • 73 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.24377 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cryzl1 35
  • 69.85 (n)
  • 66.47 (a)
Str.20074 35
(Danio rerio)
Actinopterygii cryzl1 35
  • 60.95 (n)
  • 61.05 (a)
cryzl1 36
  • 59 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
Species with no ortholog for CRYZL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CRYZL1 Gene

Gene Tree for CRYZL1 (if available)
Gene Tree for CRYZL1 (if available)

Paralogs for CRYZL1 Gene

genes like me logo Genes that share paralogs with CRYZL1: view

No data available for Paralogs for CRYZL1 Gene

Variants for CRYZL1 Gene

Sequence variations from dbSNP and Humsavar for CRYZL1 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs13399 -- 33,595,769(-) TGAAG(A/T)TTGGA missense, reference
rs1134132 -- 33,598,849(-) ATACA(C/G)TAACA intron-variant
rs1136618 -- 33,594,754(-) gaggc(A/G)gaaga intron-variant
rs1136619 -- 33,594,751(-) GCAGA(A/G)GAATC intron-variant
rs1136620 -- 33,594,740(-) gcttg(A/G)acctg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CRYZL1 Gene

Variant ID Type Subtype PubMed ID
nsv913724 CNV Loss 21882294

Relevant External Links for CRYZL1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRYZL1 Gene

Disorders for CRYZL1 Gene

No disorders were found for CRYZL1 Gene.

No data available for UniProtKB/Swiss-Prot for CRYZL1 Gene

Publications for CRYZL1 Gene

  1. Identification of a zeta-crystallin (quinone reductase)-like 1 gene (CRYZL1) mapped to human chromosome 21q22.1. (PMID: 10191096) Kim M.-Y. … Soh J. (Genomics 1999) 2 3 4 23
  2. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for CRYZL1 Gene

Sources for CRYZL1 Gene

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