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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CRYZ Gene

protein-coding   GIFtS: 60
GCID: GC01M075171

crystallin, zeta (quinone reductase)
 Explore 8 diseases affiliated with
CRYZ via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CRYZ    

Aliases
for CRYZ gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Crystallin, Zeta (Quinone Reductase)1 2
NADPH:Quinone Reductase2 3
EC 1.6.5.53 8
Quinone Oxidoreductase2
Zeta-Crystallin1

External Ids:    HGNC: 24191   Entrez Gene: 14292   Ensembl: ENSG000001167917   OMIM: 1236915   UniProtKB: Q082573   

Export aliases for CRYZ gene to outside databases

Previous GC identifers: GC01M075290 GC01M074149 GC01M074533 GC01M074541 GC01M074883 GC01M074943 GC01M073305


Summaries
for CRYZ gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CRYZ:
Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the
major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. The former
class is also called phylogenetically-restricted crystallins. This gene encodes a taxon-specific crystallin protein
which has NADPH-dependent quinone reductase activity distinct from other known quinone reductases. It lacks alcohol
dehydrogenase activity although by similarity it is considered a member of the zinc-containing alcohol dehydrogenase
family. Unlike other mammalian species, in humans, lens expression is low. Alternatively spliced transcript variants
encoding different isoforms have been found for this gene. One pseudogene is known to exist. (provided by RefSeq, Sep
2008)

UniProtKB/Swiss-Prot: QOR_HUMAN, Q08257
Function: Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process.
Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in
the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species.
Enhances the stability of mRNA coding for BCL2. NADPH binding interferes with mRNA binding

Gene Wiki entry for CRYZ


Genomic Views
for CRYZ gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CRYZ gene promoter:
         COUP-TF1   COUP   HNF-4alpha2   HNF-4alpha1   Meis-1b   SRY   COUP-TF   Meis-1a   Pax-4a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CRYZ promoter sequence
   Search SABiosciences Chromatin IP Primers for CRYZ

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CRYZ


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31.1   Ensembl cytogenetic band:  1p31.1   HGNC cytogenetic band: 1p31.1

CRYZ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRYZ gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M075171:  view genomic region     (about GC identifiers)

Start:
 75,171,170 bp from pter      End:
 75,199,092 bp from pter
Size:
 27,923 bases      Orientation:
 minus strand

Proteins
for CRYZ gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: QOR_HUMAN, Q08257 (See protein sequence)
Recommended Name: Quinone oxidoreductase  
Size: 329 amino acids; 35207 Da
Subunit: Homotetramer
Subcellular location: Cytoplasm
1 PDB 3D structure from and Proteopedia for CRYZ:
1YB5 (3D)    
Secondary accessions: D3DQ76 Q53FT0 Q59EU7 Q5HYE7 Q6NSK9
Alternative splicing: 2 isoforms:  Q08257-1   Q08257-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CRYZ: NX_Q08257

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q08257

    • 4 DME Specific Peptides for CRYZ (Q08257)
     EINPRDTM  SSTKEEFQQ  VLQNGAHEVFNH  AGESVLVHGASGGVGLA 

    CRYZ Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001123514.1  NP_001123515.1  NP_001128231.1  NP_001880.2  

    ENSEMBL proteins: 
     ENSP00000359909   ENSP00000339399   ENSP00000359908   ENSP00000359907   ENSP00000404289  
     ENSP00000399805  

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    Novus Biologicals CRYZ Proteins
    Novus Biologicals CRYZ Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005625soluble fraction ----
    GO:0005737cytoplasm IDA--
    GO:0005794Golgi apparatus IDA--
    GO:0005829cytosol IDA17497241
    GO:0043231intracellular membrane-bounded organelle IDA--


    CRYZ for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for CRYZ gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CRYZ for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR013149 ADH_C
     IPR011032 GroES-like
     IPR013154 ADH_GroES-like
     IPR002364 Quin_OxRdtase/zeta-crystal_CS
     IPR002085 ADH_SF_Zn-type

    Graphical View of Domain Structure for InterPro Entry Q08257

    ProtoNet protein and cluster: Q08257

    2 Blocks protein families:
    IPB002364 Quinone oxidoreductase/zeta-crystallin
    IPB013154 Alcohol dehydrogenase GroES-like


    UniProtKB/Swiss-Prot: QOR_HUMAN, Q08257
    Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily


    Function
    for CRYZ gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: QOR_HUMAN, Q08257
    Function: Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process.
    Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in
    the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species.
    Enhances the stability of mRNA coding for BCL2. NADPH binding interferes with mRNA binding
    Catalytic activity: NADPH + 2 quinone = NADP(+) + 2 semiquinone

         Genatlas biochemistry entry for CRYZ:
    crystallin,zeta polypeptide (quinone reductase)

    Enzyme Number (IUBMB): EC 1.6.5.51 2

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0003730mRNA 3'-UTR binding IDA17497241
    GO:0003960NADPH:quinone reductase activity IDA17497241
    GO:0008270zinc ion binding IEA--
    GO:0016491oxidoreductase activity ----


    CRYZ for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for CRYZ:
     Decreased viability of wild-ty  Increased Salmonella enterica  


    Pathways & Interactions
    for CRYZ gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CRYZ

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/62 Interacting proteins for CRYZ (Q082573 ENSP000003393994) via UniProtKB, MINT, STRING, and/or I2D (see all 62)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MCCP235083, ENSP000003862274I2D: score=1 STRING: ENSP00000386227
    CRYAAP024893, ENSP000002915544I2D: score=2 STRING: ENSP00000291554
    IKBKEQ141643I2D: score=1 
    ACOT7ENSP000003670864STRING: ENSP00000367086
    GPX7ENSP000003546774STRING: ENSP00000354677
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007601visual perception TAS7835889
    GO:0042178xenobiotic catabolic process IDA17497241
    GO:0051289protein homotetramerization IPI17497241


    CRYZ for ontologies           About GeneDecksing



    Drugs & Compounds
    for CRYZ gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CRYZ

    7 HMDB Compounds for CRYZ    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adrenochrome o-semiquinoneAdcSq ----
    Dopachrome o-semiquinoneleukodopachrome O-semiquinone radical;DcSq 18766-67-1--
    Leukoaminochromeleucoaminochrome;2,3-dihydro-5,6-dihydroxyindole;5,6-dihydroxyindoline;56DHInn;indoline-5,6-diol;5,6-dihydroxy-2,3-dihydroindole 29539-03-5--
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--
    NADPH2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)53-57-6--
    Noradrenochrome o-semiquinonenAdcSq ----
    Quinone1,4-Benzoquine (see all 25)106-51-4--

    2 DrugBank Compounds for CRYZ    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    DicumarolBis-Hydroxycoumarin (see all 4)66-76-2targetinhibitor17305492 1722672 12882764 10561120 16700548
    2'-Monophosphoadenosine 5'-Diphosphoribose-- --target--17139284 17016423

    Search CenterWatch for drugs/clinical trials and news about CRYZ / QOR 

    Transcripts
    for CRYZ gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CRYZ gene (4 alternative transcripts): 
    NM_001130042.1  NM_001130043.1  NM_001134759.1  NM_001889.3  

    Unigene Cluster for CRYZ:

    Crystallin, zeta (quinone reductase)
    Hs.83114  [show with all ESTs]
    Unigene Representative Sequence: BX649061
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370872 ENST00000340866 ENST00000492102 ENST00000370871 ENST00000370870
    ENST00000441120 ENST00000417775(uc001dgk.3 uc001dgj.3 uc001dgl.3 uc001dgm.3)


    miRNA
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    Inhib. RNA
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    OriGene shRNA RFP: CRYZ
    OriGene siRNA: CRYZ
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    Clone
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    Additional cDNA sequence: 

    AB209714.1 AK123469.1 AK128794.1 AK223150.1 AK223201.1 AK314813.1 BC039578.1 BC070058.1 
    BX647883.1 BX649061.1 L13278.1 

    21 DOTS entries:

    DT.317064  DT.91958776  DT.451787  DT.40197655  DT.100795962  DT.121406059  DT.100795957  DT.121406041 
    DT.91760330  DT.100809052  DT.121406021  DT.121406038  DT.121406042  DT.121406070  DT.91760318  DT.91760321 
    DT.91760322  DT.91760323  DT.95170655  DT.95170662  DT.97813930 

    24/243 AceView cDNA sequences (see all 243):

    BQ772916 BM315014 BX445370 BC039578 BX097794 BX365558 BG391747 CD108812 
    CR594192 BQ011562 BU619437 T28683 AW013953 AA948647 CR595439 AW167057 
    AI978806 CA395829 CR620400 BM315099 BQ214457 BP362209 BX647883 CA430131 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for CRYZ (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c · 12d
    SP1:                    -     -     -     -     -                                                                 -                                 
    SP2:                                      -     -                                                                 -                                 
    SP3:                    -     -     -     -     -                                                           -     -                                 
    SP4:                                      -     -                             -     -                                                               
    SP5:                    -     -     -     -     -     -     -                 -     -                                                               


    ECgene alternative splicing isoforms for CRYZ

    Expression
    for CRYZ gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CRYZ expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACTGTATTGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CRYZ expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)Intermediate Mesoderm, Kidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CRYZ Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CRYZ

    SOURCE GeneReport for Unigene cluster: Hs.83114

    UniProtKB/Swiss-Prot: QOR_HUMAN, Q08257
    Tissue specificity: Only very low amounts in the lens

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    In Situ
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    Orthologs
    for CRYZ gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CRYZ gene from 8/27 species (see all 27)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CRYZ1 crystallin, zeta (quinone reductase) 67.89(n)
    70.03(a)    		   772289  NM_001079763.1  NP_001073231.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CRYZ6
    		 --
    		 65(a)
    		 1 ↔ 1
    		 GL343194.1(2754248-2767146)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.82762 Transcribed sequence with weak similarity to protein more 74.6(n)    CF376815.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.145142 Danio rerio mRNA similar to crystallin, zeta (quinone more 74.95(n)    BC052129.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea F39B2.31 , 3 Zinc-binding dehydrogenases3
    Protein F39B2.31    		 41(a)3
    50.8(n)1
    43.13(a)1    		   I(14796259-14797523)3
    1733461  NM_061176.31  NP_493577.11 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes (YNL134C)4
    ZTA11    		 Putative protein of unknown function with similarity more4
    Zta1p1    		 43.98(n)1
    27.42(a)1    		   14(373581-372451)4
    8523351  NP_009602.11  8555884 
     NP_014265.14 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT5G615101 NADPH2:quinone reductase 45.73(n)
    30.62(a)    		   836272  NM_125544.3  NP_200959.2 
    rice
    (Oryza sativa)    		 Liliopsida Os03g01016001 hypothetical protein 44.44(n)
    30.5(a)    		   4331289  NM_001055190.1  NP_001048655.1 


    ENSEMBL Gene Tree for CRYZ (if available)
    TreeFam Gene Tree for CRYZ (if available) 

    Paralogs
    for CRYZ gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CRYZ gene
    VAT12  ZADH22  VAT1L2  TP53I32  
    4 SIMAP similar genes for CRYZ using alignment to 4 protein entries:     QOR_HUMAN (see all proteins):
    VAT1    VAT1L    TP53I3    DKFZp547P162

    CRYZ for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for CRYZ
    PGOHUM00000250724 PGOHUM00000232951


    Genomic Variants
    for CRYZ gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/612 NCBI SNPs in CRYZ are shown (see all 612)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs121194281,2
    		C,H,--73305256(+) TTAGCG/AGTGTT 4 -- ds50015Minor allele frequency- A:0.01NS EA NA 540
    rs412892221,2
    		--73305535(+) AGAAGC/TGATGA 4 -- ds50010--------
    rs11315551,2
    		--73305585(-) GTCTAT/CAGAAA 4 -- ut313Minor allele frequency- C:0.03NA WA 122
    rs10511771,2
    		C,F,--73305953(+) TTTAGT/ATCAGA 4 -- ut316Minor allele frequency- A:0.01MN NA CSA 329
    rs14246701,2
    		C,O,A,--73306187(+) TTGAGA/TCAGAT 4 -- ut31 ese35Minor allele frequency- T:0.02MN NA WA 444
    rs133756241,2
    		H--73306242(+) TGCTTC/TTGCTC 4 -- ut314Minor allele frequency- T:0.00NS EA 398
    rs751398441,2
    		F,--73306247(+) CTGCTC/GTCTAA 4 -- ut311Minor allele frequency- G:0.05WA 118
    rs745609581,2
    		C,F,--73308051(+) NNNNAG/AGTTTG 4 -- int11Minor allele frequency- A:0.03WA 118
    rs175521341,2
    		C,F,H,--73308110(+) CCTCAG/AGGATG 4 -- int112Minor allele frequency- A:0.03NA NS EA WA CSA 681
    rs170958121,2
    		C,--73308237(+) AAGGAT/CTGAAA 4 -- int14Minor allele frequency- C:0.04NA WA 260

    HapMap Linkage Disequilibrium report for CRYZ (75171170 - 75199092 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for CRYZ
         1 Indel: 68852

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    Disorders / Diseases
    for CRYZ gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CRYZ for disorders           About GeneDecksing

    OMIM gene information: 123691    OMIM disorders: --

    8 diseases for CRYZ:    About MalaCards
    balkan nephropathy    alcoholism    acute lymphocytic leukemia    lymphocytic leukemia
    parkinson's disease    cataract    leukemia    nephropathy

    Genetic Association Database (GAD): CRYZ
    Human Genome Epidemiology (HuGE) Navigator: CRYZ (1 document)

    Export disorders for CRYZ gene to outside databases

    Publications
    for CRYZ gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CRYZ gene, integrated from 9 sources (see all 38):
    (articles sorted by number of sources associating them with CRYZ)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Organization of the human zeta-crystallin/quinone reductase gene (CRYZ). (PubMed id 8088825)1, 2, 9 Gonzalez P.... Zigler J.S. Jr. (1994)
    2. {zeta}-Crystallin is a bcl-2 mRNA binding protein involved in bcl-2 overexpression in T-cell acute lymphocytic leukemia. (PubMed id 20103721)1, 2 Lapucci A.... Capaccioli S. (2010)
    3. Human and yeast zeta-crystallins bind AU-rich elements in RNA. (PubMed id 17497241)1, 2 Fernandez M.R.... Pares X. (2007)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. [Polymorphism of MAO-B gene and NAD(P)H: quinone oxidoreductase gene in Parkinson's disease] (PubMed id 11295131)1, 4 Shao M....Chen B. (2001)
    6. Molecular cloning and sequencing of zeta-crystallin/quinone reductase cDNA from human liver. (PubMed id 8466529)1, 2 Gonzalez P.... Zigler J.S. Jr. (1993)
    7. Assignment of the zeta-crystallin gene (CRYZ) to human chromosome 1p22-p31 and identification of restriction fragment length polymorphisms. (PubMed id 7835889)1, 9 Heinzmann C....Bateman J.B. (1994)
    8. Genome-wide association analysis identifies TYW3/CRYZ and NDST4 loci associated with circulating resistin levels. (PubMed id 22843503)1 Qi Q....Qi L. (2012)
    9. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    10. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)

    External Searches for CRYZ gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CRYZ gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1429 HGNC: 2419 AceView: CRYZ Ensembl:ENSG00000116791 euGenes: HUgn1429
    ECgene: CRYZ H-InvDB: CRYZ

    Other Databases showing CRYZ gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CRYZ gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CRYZ Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CRYZ gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CRYZ gene:
    Search GeneIP for patents involving CRYZ

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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