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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CRYZ Gene

protein-coding   GIFtS: 62
GCID: GC01M075171

Crystallin, Zeta (Quinone Reductase)

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Crystallin, Zeta (Quinone Reductase)1 2
NADPH:Quinone Reductase2 3
EC 1.6.5.53 8
Quinone Oxidoreductase2
Zeta-crystallin3

External Ids:    HGNC: 24191   Entrez Gene: 14292   Ensembl: ENSG000001167917   OMIM: 1236915   UniProtKB: Q082573   

Export aliases for CRYZ gene to outside databases

Previous GC identifers: GC01M075290 GC01M074149 GC01M074533 GC01M074541 GC01M074883 GC01M074943 GC01M073305


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CRYZ Gene:
Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class
constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the
lens. The former class is also called phylogenetically-restricted crystallins. This gene encodes a taxon-specific
crystallin protein which has NADPH-dependent quinone reductase activity distinct from other known quinone
reductases. It lacks alcohol dehydrogenase activity although by similarity it is considered a member of the
zinc-containing alcohol dehydrogenase family. Unlike other mammalian species, in humans, lens expression is low.
Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One
pseudogene is known to exist. (provided by RefSeq, Sep 2008)

GeneCards Summary for CRYZ Gene: 
CRYZ (crystallin, zeta (quinone reductase)) is a protein-coding gene. Diseases associated with CRYZ include balkan nephropathy, and alcoholism. GO annotations related to this gene include NADPH:quinone reductase activity and mRNA 3'-UTR binding. An important paralog of this gene is VAT1.

UniProtKB/Swiss-Prot: QOR_HUMAN, Q08257
Function: Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer
process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in
vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of
target mRNA species. Enhances the stability of mRNA coding for BCL2. NADPH binding interferes with mRNA binding

Gene Wiki entry for CRYZ Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CRYZ gene promoter:
         COUP-TF1   COUP   HNF-4alpha2   HNF-4alpha1   Meis-1b   SRY   COUP-TF   Meis-1a   Pax-4a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCRYZ promoter sequence
   Search SABiosciences Chromatin IP Primers for CRYZ

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CRYZ


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31.1   Ensembl cytogenetic band:  1p31.1   HGNC cytogenetic band: 1p31.1

CRYZ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRYZ gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M075171:  view genomic region     (about GC identifiers)

Start:
75,171,170 bp from pter      End:
75,199,092 bp from pter
Size:
27,923 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: QOR_HUMAN, Q08257 (See protein sequence)
Recommended Name: Quinone oxidoreductase  
Size: 329 amino acids; 35207 Da
Subunit: Homotetramer
Subcellular location: Cytoplasm
1 PDB 3D structure from and Proteopedia for CRYZ:
1YB5 (3D)    
Secondary accessions: A6NN60 D3DQ76 Q53FT0 Q59EU7 Q5HYE7 Q6NSK9
Alternative splicing: 3 isoforms:  Q08257-1   Q08257-2   Q08257-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CRYZ: NX_Q08257

Explore proteomics data for CRYZ at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q08257

  • 4 DME Specific Peptides for CRYZ (Q08257)
     EINPRDTM  SSTKEEFQQ  VLQNGAHEVFNH  AGESVLVHGASGGVGLA 

    CRYZ Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CRYZ Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001123514.1  NP_001123515.1  NP_001128231.1  NP_001880.2  

    ENSEMBL proteins: 
     ENSP00000359909   ENSP00000339399   ENSP00000359908   ENSP00000359907   ENSP00000404289  
     ENSP00000399805  

    Human Recombinant Protein Products for CRYZ: 
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    Novus Biologicals CRYZ Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005794Golgi apparatus IDA--
    GO:0005829cytosol IDA17497241
    GO:0043231intracellular membrane-bounded organelle IDA--

    CRYZ for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro protein domains (see all 6):
     IPR013149 ADH_C
     IPR011032 GroES-like
     IPR013154 ADH_GroES-like
     IPR002364 Quin_OxRdtase/zeta-crystal_CS
     IPR002085 ADH_SF_Zn-type

    Graphical View of Domain Structure for InterPro Entry Q08257

    ProtoNet protein and cluster: Q08257

    2 Blocks protein domains:
    IPB002364 Quinone oxidoreductase/zeta-crystallin
    IPB013154 Alcohol dehydrogenase GroES-like


    UniProtKB/Swiss-Prot: QOR_HUMAN, Q08257
    Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily


    CRYZ for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: QOR_HUMAN, Q08257
    Function: Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer
    process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in
    vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of
    target mRNA species. Enhances the stability of mRNA coding for BCL2. NADPH binding interferes with mRNA binding
    Catalytic activity: NADPH + 2 quinone = NADP(+) + 2 semiquinone

         Genatlas biochemistry entry for CRYZ:
    crystallin,zeta polypeptide (quinone reductase)

         Enzyme Number (IUBMB): EC 1.6.5.51 2

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003730mRNA 3'-UTR binding IDA17497241
    GO:0003960NADPH:quinone reductase activity IDA17497241
    GO:0008270zinc ion binding IEA--
    GO:0016491oxidoreductase activity ----
    GO:0016747transferase activity, transferring acyl groups other than amino-acyl groups ----
         
    CRYZ for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CRYZ:
     Decreased viability of wild-ty  Increased Salmonella enterica  

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CRYZ

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/62 Interacting proteins for CRYZ (Q082573 ENSP000003393994) via UniProtKB, MINT, STRING, and/or I2D (see all 62)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CRYAAP024893, ENSP000002915544I2D: score=2 STRING: ENSP00000291554
    MCCP235083, ENSP000003862274I2D: score=1 STRING: ENSP00000386227
    IKBKEQ141643I2D: score=1 
    ACOT7ENSP000003670864STRING: ENSP00000367086
    GPX7ENSP000003546774STRING: ENSP00000354677
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007601visual perception TAS7835889
    GO:0042178xenobiotic catabolic process IDA17497241
    GO:0051289protein homotetramerization IPI17497241
    GO:0055114oxidation-reduction process ----

    CRYZ for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CRYZ (QOR)

    7 HMDB Compounds for CRYZ    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adrenochrome o-semiquinoneAdcSq ----
    Dopachrome o-semiquinoneleukodopachrome O-semiquinone radical;DcSq 18766-67-1--
    Leukoaminochromeleucoaminochrome;2,3-dihydro-5,6-dihydroxyindole;5,6-dihydroxyindoline;56DHInn;indoline-5,6-diol;5,6-dihydroxy-2,3-dihydroindole 29539-03-5--
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--
    NADPH2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)53-57-6--
    Noradrenochrome o-semiquinonenAdcSq ----
    Quinone1,4-Benzoquine (see all 25)106-51-4--

    2 DrugBank Compounds for CRYZ    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    DicumarolBis-Hydroxycoumarin (see all 4)66-76-2targetinhibitor17305492 1722672 12882764 10561120 16700548
    2'-Monophosphoadenosine 5'-Diphosphoribose-- --target--17139284 17016423

    Search CenterWatch for drugs/clinical trials and news about CRYZ / QOR

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CRYZ gene (4 alternative transcripts): 
    NM_001130042.1  NM_001130043.1  NM_001134759.1  NM_001889.3  

    Unigene Cluster for CRYZ:

    Crystallin, zeta (quinone reductase)
    Hs.83114  [show with all ESTs]
    Unigene Representative Sequence: BX649061
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370872 ENST00000340866 ENST00000492102 ENST00000370871 ENST00000370870
    ENST00000441120 ENST00000417775(uc001dgk.3 uc001dgj.3 uc001dgl.3 uc001dgm.3)


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    Additional mRNA sequence: 

    AB209714.1 AK123469.1 AK128794.1 AK223150.1 AK223201.1 AK314813.1 BC039578.1 BC070058.1 
    BX647883.1 BX649061.1 L13278.1 

    21 DOTS entries:

    DT.317064  DT.91958776  DT.451787  DT.40197655  DT.100795962  DT.121406059  DT.100795957  DT.121406041 
    DT.91760330  DT.100809052  DT.121406021  DT.121406038  DT.121406042  DT.121406070  DT.91760318  DT.91760321 
    DT.91760322  DT.91760323  DT.95170655  DT.95170662  DT.97813930 

    24/243 AceView cDNA sequences (see all 243):

    CA446797 AA035180 BG391747 AI978806 AW167057 BX097794 AW013953 CA445304 
    BQ214457 BM314808 BQ011562 CA395829 BU632079 T28683 BQ772916 BE336715 
    CA430131 BX647883 CR595439 BU619437 L13278 NM_001889 CD108812 CR620400 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for CRYZ (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c · 12d
    SP1:                    -     -     -     -     -                                                                 -                                 
    SP2:                                      -     -                                                                 -                                 
    SP3:                    -     -     -     -     -                                                           -     -                                 
    SP4:                                      -     -                             -     -                                                               
    SP5:                    -     -     -     -     -     -     -                 -     -                                                               


    ECgene alternative splicing isoforms for CRYZ

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CRYZ expression in normal human tissues (normalized intensities)      CRYZ embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTGTATTGG
    CRYZ Expression
    About this image


    CRYZ expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Endothelium (Cardiovascular System)
             Embryoid bodies ( Two-step protocol for endothelial differentiation by embryoid...
     
     Liver (Hepatobiliary System)

    See CRYZ Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CRYZ

    SOURCE GeneReport for Unigene cluster: Hs.83114

    UniProtKB/Swiss-Prot: QOR_HUMAN, Q08257
    Tissue specificity: Only very low amounts in the lens

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CRYZ gene from 9/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cryz1 , 5 crystallin, zeta1, 5 79.03(n)1
    81.16(a)1
      3 (79.25 cM)5
    129721  NM_009968.31  NP_034098.11 
     1545971975 
    chicken
    (Gallus gallus)
    Aves CRYZ1 crystallin, zeta (quinone reductase) 67.89(n)
    70.03(a)
      772289  NM_001079763.1  NP_001073231.1 
    lizard
    (Anolis carolinensis)
    Reptilia CRYZ6
    Uncharacterized protein
    66(a)
    1 ↔ 1
    GL343194.1(2751458-2775533)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.82762 Transcribed sequence with weak similarity to protein more 74.6(n)    CF376815.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.145142 Danio rerio mRNA similar to crystallin, zeta (quinone more 74.95(n)    BC052129.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F39B2.31 , 3 Zinc-binding dehydrogenases3
    Protein F39B2.31
    41(a)3
    50.8(n)1
    43.13(a)1
      I(14796259-14797523)3
    1733461  NM_061176.31  NP_493577.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes (YNL134C)4
    ZTA11
    Putative protein of unknown function with similarity more4
    Zta1p1
    43.98(n)1
    27.42(a)1
      14(373581-372451)4
    8523351  NP_009602.11  8555884 
     NP_014265.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G615101 NADPH2:quinone reductase 45.73(n)
    30.62(a)
      836272  NM_125544.3  NP_200959.2 
    rice
    (Oryza sativa)
    Liliopsida Os03g01016001 hypothetical protein 44.44(n)
    30.5(a)
      4331289  NM_001055190.1  NP_001048655.1 


    ENSEMBL Gene Tree for CRYZ (if available)
    TreeFam Gene Tree for CRYZ (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CRYZ gene
    VAT12  VAT1L2  TP53I32  MECR2  
    4 SIMAP similar genes for CRYZ using alignment to 3 protein entries:     QOR_HUMAN (see all proteins):
    VAT1    VAT1L    TP53I3    DKFZp547P162

    CRYZ for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for CRYZ
    PGOHUM00000250724 PGOHUM00000232951


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/761 SNPs in CRYZ are shown (see all 761)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1118744041,2
    C--73307375(+) TAGAA-/ATATGTT 4 -- int11Minor allele frequency- AT:0.00CSA 2
    rs108901401,2
    C,F,A,H--73308548(+) AAGGGT/GGTATT 4 -- int15Minor allele frequency- G:0.01EA NS NA 300
    rs108901411,2
    C,F,A,H--73308549(+) AGGGTG/ATATTA 4 -- int12Minor allele frequency- A:0.50NA 4
    rs30414521,2
    C--73327569(+) aaaaa-/A/AA  
            
    attag
    4 -- int11NA 2
    rs1121310031,2
    C--73327673(+) TGAGAT/-GATGC 4 -- int11Minor allele frequency- -:0.00CSA 2
    rs1447899891,2
    C--73327673(+) GAGAG-/C/TATGCC 4 -- int10--------
    rs412892221,2
    --75171132(+) AGAAGC/TGATGA 4 -- ds50010--------
    rs10511771,2
    C,F--75171550(+) TTTAGT/ATCAGA 4 -- ut316Minor allele frequency- A:0.01MN NA CSA 329
    rs14246701,2
    C,F,O,A--75171784(+) TTGAGA/TCAGAT 4 -- ut31 ese35Minor allele frequency- T:0.02MN NA WA 444
    rs133756241,2
    H--75171839(+) TGCTTC/TTGCTC 4 -- ut314Minor allele frequency- T:0.00NS EA 398

    HapMap Linkage Disequilibrium report for CRYZ (75171170 - 75199092 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for CRYZ:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2668367CNV Deletion23128226
    esv2662359CNV Deletion23128226
    nsv1422CNV Insertion18451855
    nsv509346CNV Insertion20534489
    esv21668CNV Gain19812545
    nsv871152CNV Gain21882294
    nsv830259CNV Gain17160897

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    SeqTarget long-range PCR primers for resequencing CRYZ
    DNA2.0 Custom Variant and Variant Library Synthesis for CRYZ

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 123691    OMIM disorders: --

    6 diseases for CRYZ:    About MalaCards
    balkan nephropathy    alcoholism    acute lymphocytic leukemia    cataract
    parkinson's disease    leukemia

    2 diseases from the University of Copenhagen DISEASES database for CRYZ:
    Cancer     Interstitial nephritis

    CRYZ for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): CRYZ
    Human Genome Epidemiology (HuGE) Navigator: CRYZ (1 document)

    Export disorders for CRYZ gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CRYZ gene, integrated from 9 sources (see all 39):
    (articles sorted by number of sources associating them with CRYZ)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Organization of the human zeta-crystallin/quinone reductase gene (CRYZ). (PubMed id 8088825)1, 2, 9 Gonzalez P.... Zigler J.S. Jr. (1994)
    2. {zeta}-Crystallin is a bcl-2 mRNA binding protein involved in bcl-2 overexpression in T-cell acute lymphocytic leukemia. (PubMed id 20103721)1, 2 Lapucci A.... Capaccioli S. (2010)
    3. Human and yeast zeta-crystallins bind AU-rich elements in RNA. (PubMed id 17497241)1, 2 Fernandez M.R.... Pares X. (2007)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. [Polymorphism of MAO-B gene and NAD(P)H: quinone oxidoreductase gene in Parkinson's disease] (PubMed id 11295131)1, 4 Shao M....Chen B. (2001)
    7. Molecular cloning and sequencing of zeta-crystallin/quinone reductase cDNA from human liver. (PubMed id 8466529)1, 2 Gonzalez P.... Zigler J.S. Jr. (1993)
    8. Assignment of the zeta-crystallin gene (CRYZ) to human chromosome 1p22-p31 and identification of restriction fragment length polymorphisms. (PubMed id 7835889)1, 9 Heinzmann C....Bateman J.B. (1994)
    9. Genome-wide association analysis identifies TYW3/CRYZ and NDST4 loci associated with circulating resistin levels. (PubMed id 22843503)1 Qi Q....Qi L. (2012)
    10. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1429 HGNC: 2419 AceView: CRYZ Ensembl:ENSG00000116791 euGenes: HUgn1429
    ECgene: CRYZ H-InvDB: CRYZ

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CRYZ Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CRYZ gene:
    Search GeneIP for patents involving CRYZ

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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