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Aliases for CRYZ Gene

Aliases for CRYZ Gene

  • Crystallin Zeta 2 3 5
  • EC 1.6.5.5 4 61
  • Crystallin, Zeta (Quinone Reductase) 2
  • NADPH:Quinone Reductase 4
  • Zeta-Crystallin 4

External Ids for CRYZ Gene

Previous GeneCards Identifiers for CRYZ Gene

  • GC01M075290
  • GC01M074149
  • GC01M074533
  • GC01M074541
  • GC01M074883
  • GC01M074943
  • GC01M075171
  • GC01M073305

Summaries for CRYZ Gene

Entrez Gene Summary for CRYZ Gene

  • Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. The former class is also called phylogenetically-restricted crystallins. This gene encodes a taxon-specific crystallin protein which has NADPH-dependent quinone reductase activity distinct from other known quinone reductases. It lacks alcohol dehydrogenase activity although by similarity it is considered a member of the zinc-containing alcohol dehydrogenase family. Unlike other mammalian species, in humans, lens expression is low. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One pseudogene is known to exist. [provided by RefSeq, Sep 2008]

GeneCards Summary for CRYZ Gene

CRYZ (Crystallin Zeta) is a Protein Coding gene. GO annotations related to this gene include oxidoreductase activity and mRNA 3-UTR binding. An important paralog of this gene is VAT1.

UniProtKB/Swiss-Prot for CRYZ Gene

  • Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3-UTR of target mRNA species. Enhances the stability of mRNA coding for BCL2. NADPH binding interferes with mRNA binding.

Gene Wiki entry for CRYZ Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRYZ Gene

Genomics for CRYZ Gene

Regulatory Elements for CRYZ Gene

Enhancers for CRYZ Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G074729 1.6 Ensembl ENCODE dbSUPER 77.3 +1.0 1001 5.1 PKNOX1 FOXA2 MLX CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 CRYZ TYW3 ENSG00000272864
GH01G075074 0.7 FANTOM5 ENCODE 3.9 -341.7 -341731 1.3 POU5F1 RBBP5 CHD7 CRYZ GC01M074990 ENSG00000261213
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CRYZ on UCSC Golden Path with GeneCards custom track

Promoters for CRYZ Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000008586 108 2201 PKNOX1 CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766
ENSR00000252506 1508 201 HDAC1 TBP ARID4B ZNF48 RARA YY1 GATA4 GATA2 RELB IKZF2

Genomic Location for CRYZ Gene

Chromosome:
1
Start:
74,705,482 bp from pter
End:
74,733,408 bp from pter
Size:
27,927 bases
Orientation:
Minus strand

Genomic View for CRYZ Gene

Genes around CRYZ on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRYZ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRYZ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRYZ Gene

Proteins for CRYZ Gene

  • Protein details for CRYZ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q08257-QOR_HUMAN
    Recommended name:
    Quinone oxidoreductase
    Protein Accession:
    Q08257
    Secondary Accessions:
    • A6NN60
    • D3DQ76
    • Q53FT0
    • Q59EU7
    • Q5HYE7
    • Q6NSK9

    Protein attributes for CRYZ Gene

    Size:
    329 amino acids
    Molecular mass:
    35207 Da
    Quaternary structure:
    • Homotetramer.

    Three dimensional structures from OCA and Proteopedia for CRYZ Gene

    Alternative splice isoforms for CRYZ Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CRYZ Gene

Selected DME Specific Peptides for CRYZ Gene

Q08257:
  • VLQNGAHEVFNH
  • SSTKEEFQQ
  • EINPRDTM
  • AGESVLVHGASGGVGLA

Post-translational modifications for CRYZ Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for CRYZ Gene

Suggested Antigen Peptide Sequences for CRYZ Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q08257

UniProtKB/Swiss-Prot:

QOR_HUMAN :
  • Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
Family:
  • Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
genes like me logo Genes that share domains with CRYZ: view

No data available for Gene Families for CRYZ Gene

Function for CRYZ Gene

Molecular function for CRYZ Gene

GENATLAS Biochemistry:
crystallin,zeta polypeptide (quinone reductase)
UniProtKB/Swiss-Prot CatalyticActivity:
NADPH + 2 quinone = NADP(+) + 2 semiquinone.
UniProtKB/Swiss-Prot Function:
Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3-UTR of target mRNA species. Enhances the stability of mRNA coding for BCL2. NADPH binding interferes with mRNA binding.

Enzyme Numbers (IUBMB) for CRYZ Gene

Gene Ontology (GO) - Molecular Function for CRYZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003730 mRNA 3-UTR binding IDA 17497241
GO:0003960 NADPH:quinone reductase activity IDA,IEA 17497241
GO:0008270 zinc ion binding IEA --
GO:0016491 oxidoreductase activity IEA --
GO:0070402 NADPH binding IDA 17497241
genes like me logo Genes that share ontologies with CRYZ: view
genes like me logo Genes that share phenotypes with CRYZ: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CRYZ

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CRYZ Gene

Localization for CRYZ Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRYZ Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CRYZ gene
Compartment Confidence
extracellular 5
cytosol 5
nucleus 3
mitochondrion 2
golgi apparatus 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CRYZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA 17497241
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with CRYZ: view

Pathways & Interactions for CRYZ Gene

No Data Available

Gene Ontology (GO) - Biological Process for CRYZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007601 visual perception TAS 7835889
GO:0042178 xenobiotic catabolic process IDA 17497241
GO:0051289 protein homotetramerization IPI 17497241
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with CRYZ: view

No data available for Pathways by source and SIGNOR curated interactions for CRYZ Gene

Drugs & Compounds for CRYZ Gene

(2) Drugs for CRYZ Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dicumarol Approved Pharma Target, inhibitor 0
2'-Monophosphoadenosine 5'-Diphosphoribose Experimental Pharma Target 0

(3) Additional Compounds for CRYZ Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
NADP
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
53-59-8
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
Quinone
  • 1,4-Benzoquine
  • 1,4-Benzoquinone
  • 1,4-Cyclohexadiene dioxide
  • 1,4-Cyclohexadienedione
  • 1,4-Diossibenzene
106-51-4
genes like me logo Genes that share compounds with CRYZ: view

Transcripts for CRYZ Gene

Unigene Clusters for CRYZ Gene

Crystallin, zeta (quinone reductase):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CRYZ Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c · 12d
SP1: - - - - - -
SP2: - - -
SP3: - - - - - - -
SP4: - - - -
SP5: - - - - - - - - -
SP6: - - - - - - -
SP7: - - - -
SP8: - - -
SP9: - - -
SP10:
SP11: - - -
SP12: - - -
SP13:

Relevant External Links for CRYZ Gene

GeneLoc Exon Structure for
CRYZ
ECgene alternative splicing isoforms for
CRYZ

Expression for CRYZ Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CRYZ Gene

mRNA differential expression in normal tissues according to GTEx for CRYZ Gene

This gene is overexpressed in Liver (x5.9) and Kidney - Cortex (x4.2).

Protein differential expression in normal tissues from HIPED for CRYZ Gene

This gene is overexpressed in Liver, secretome (13.8) and Kidney (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CRYZ Gene



Protein tissue co-expression partners for CRYZ Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CRYZ Gene:

CRYZ

SOURCE GeneReport for Unigene cluster for CRYZ Gene:

Hs.83114

mRNA Expression by UniProt/SwissProt for CRYZ Gene:

Q08257-QOR_HUMAN
Tissue specificity: Only very low amounts in the lens.

Evidence on tissue expression from TISSUES for CRYZ Gene

  • Liver(4.8)
  • Nervous system(4.7)
  • Kidney(4.6)
  • Lung(4.5)
  • Heart(2)
  • Skin(2)
genes like me logo Genes that share expression patterns with CRYZ: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for CRYZ Gene

Orthologs for CRYZ Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CRYZ Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CRYZ 34 35
  • 98.38 (n)
cow
(Bos Taurus)
Mammalia CRYZ 34 35
  • 88.35 (n)
dog
(Canis familiaris)
Mammalia CRYZ 34 35
  • 86.32 (n)
-- 35
  • 77 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 83 (a)
OneToMany
-- 35
  • 81 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Cryz 34 16 35
  • 79.03 (n)
rat
(Rattus norvegicus)
Mammalia Cryz 34
  • 78.12 (n)
oppossum
(Monodelphis domestica)
Mammalia CRYZ 35
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves CRYZ 34 35
  • 67.89 (n)
lizard
(Anolis carolinensis)
Reptilia CRYZ 35
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cryz 34
  • 67.17 (n)
Str.8276 34
zebrafish
(Danio rerio)
Actinopterygii cryz 34 35
  • 65.54 (n)
Dr.14514 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5597 34
worm
(Caenorhabditis elegans)
Secernentea F39B2.3 36 34 35
  • 50.8 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ZTA1 35
  • 25 (a)
OneToMany
-- 37
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1760 35
  • 50 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.728 34
Species where no ortholog for CRYZ was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CRYZ Gene

ENSEMBL:
Gene Tree for CRYZ (if available)
TreeFam:
Gene Tree for CRYZ (if available)

Paralogs for CRYZ Gene

Paralogs for CRYZ Gene

(4) SIMAP similar genes for CRYZ Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for CRYZ Gene

genes like me logo Genes that share paralogs with CRYZ: view

Variants for CRYZ Gene

Sequence variations from dbSNP and Humsavar for CRYZ Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000003158 -- 74,720,748(+) ACATG(C/T)TGAAT intron-variant
rs1000020611 -- 74,704,986(+) GGATG(C/T)ACATA downstream-variant-500B
rs1000022571 -- 74,732,099(+) CTACA(G/T)CTGGG intron-variant, upstream-variant-2KB
rs1000149688 -- 74,712,332(+) CAGAA(C/G)CCCTT intron-variant
rs1000283234 -- 74,729,280(+) GAAAT(C/T)TGGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CRYZ Gene

Variant ID Type Subtype PubMed ID
esv21668 CNV gain 19812545
esv2662359 CNV deletion 23128226
esv2668367 CNV deletion 23128226
esv2762153 CNV gain 21179565
esv3564204 CNV deletion 23714750
esv3577964 CNV loss 25503493
esv3586466 CNV loss 21293372
esv3586467 CNV loss 21293372
nsv1002115 CNV gain 25217958
nsv1422 CNV insertion 18451855
nsv509346 CNV insertion 20534489
nsv546579 CNV loss 21841781
nsv830259 CNV gain 17160897

Variation tolerance for CRYZ Gene

Residual Variation Intolerance Score: 73.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.06; 92.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CRYZ Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CRYZ

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRYZ Gene

Disorders for CRYZ Gene

Relevant External Links for CRYZ

Genetic Association Database (GAD)
CRYZ
Human Genome Epidemiology (HuGE) Navigator
CRYZ
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CRYZ

No disorders were found for CRYZ Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CRYZ Gene

Publications for CRYZ Gene

  1. Organization of the human zeta-crystallin/quinone reductase gene (CRYZ). (PMID: 8088825) Gonzalez P. … Zigler J.S. Jr. (Genomics 1994) 3 4 22 64
  2. {zeta}-Crystallin is a bcl-2 mRNA binding protein involved in bcl-2 overexpression in T-cell acute lymphocytic leukemia. (PMID: 20103721) Lapucci A. … Capaccioli S. (FASEB J. 2010) 3 4 64
  3. Human and yeast zeta-crystallins bind AU-rich elements in RNA. (PMID: 17497241) Fernandez M.R. … Pares X. (Cell. Mol. Life Sci. 2007) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for CRYZ Gene

Sources for CRYZ Gene

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