Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CRYZ Gene

protein-coding   GIFtS: 63
GCID: GC01M075171

Crystallin, Zeta (Quinone Reductase)

  Search for CRYZ
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Crystallin, Zeta (Quinone Reductase)1 2
NADPH:Quinone Reductase2 3
EC 1.6.5.53 8
Quinone Oxidoreductase2
Zeta-crystallin3

External Ids:    HGNC: 24191   Entrez Gene: 14292   Ensembl: ENSG000001167917   OMIM: 1236915   UniProtKB: Q082573   

Export aliases for CRYZ gene to outside databases

Previous GC identifers: GC01M075290 GC01M074149 GC01M074533 GC01M074541 GC01M074883 GC01M074943 GC01M073305


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for CRYZ Gene:
Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class
constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the
lens. The former class is also called phylogenetically-restricted crystallins. This gene encodes a taxon-specific
crystallin protein which has NADPH-dependent quinone reductase activity distinct from other known quinone
reductases. It lacks alcohol dehydrogenase activity although by similarity it is considered a member of the
zinc-containing alcohol dehydrogenase family. Unlike other mammalian species, in humans, lens expression is low.
Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One
pseudogene is known to exist. (provided by RefSeq, Sep 2008)

GeneCards Summary for CRYZ Gene:
CRYZ (crystallin, zeta (quinone reductase)) is a protein-coding gene. GO annotations related to this gene include NADPH:quinone reductase activity and mRNA 3'-UTR binding. An important paralog of this gene is VAT1.

UniProtKB/Swiss-Prot: QOR_HUMAN, Q08257
Function: Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer
process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in
vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of
target mRNA species. Enhances the stability of mRNA coding for BCL2. NADPH binding interferes with mRNA binding

Gene Wiki entry for CRYZ Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CRYZ gene promoter:
         COUP-TF1   COUP   HNF-4alpha2   HNF-4alpha1   Meis-1b   SRY   COUP-TF   Meis-1a   Pax-4a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCRYZ promoter sequence
   Search Chromatin IP Primers for CRYZ

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CRYZ


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31.1   Ensembl cytogenetic band:  1p31.1   HGNC cytogenetic band: 1p31.1

CRYZ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRYZ gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M075171:  view genomic region     (about GC identifiers)

Start:
75,171,170 bp from pter      End:
75,199,092 bp from pter
Size:
27,923 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: QOR_HUMAN, Q08257 (See protein sequence)
Recommended Name: Quinone oxidoreductase  
Size: 329 amino acids; 35207 Da
Subunit: Homotetramer
1 PDB 3D structure from and Proteopedia for CRYZ:
1YB5 (3D)    
Secondary accessions: A6NN60 D3DQ76 Q53FT0 Q59EU7 Q5HYE7 Q6NSK9
Alternative splicing: 3 isoforms:  Q08257-1   Q08257-2   Q08257-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CRYZ: NX_Q08257

Explore proteomics data for CRYZ at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys23
  • Modification sites at PhosphoSitePlus
  • 4 DME Specific Peptides for CRYZ (Q08257)
     EINPRDTM  SSTKEEFQQ  VLQNGAHEVFNH  AGESVLVHGASGGVGLA 


    See CRYZ Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001123514.1  NP_001123515.1  NP_001128231.1  NP_001880.2  

    ENSEMBL proteins: 
     ENSP00000359909   ENSP00000339399   ENSP00000359908   ENSP00000359907   ENSP00000404289  
     ENSP00000399805  

    CRYZ Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CRYZ
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CRYZ
    GenScript Custom Purified and Recombinant Proteins Services for CRYZ
    Novus Biologicals CRYZ Proteins
    Novus Biologicals CRYZ Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for CRYZ 

    CRYZ Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CRYZ
    Novus Biologicals CRYZ Antibodies
    Abcam antibodies for CRYZ
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for CRYZ
    LSBio Antibodies in human, mouse, rat for CRYZ

    CRYZ Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CRYZ
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CRYZ
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for CRYZ 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    Selected InterPro protein domains (see all 6):
     IPR013149 ADH_C
     IPR011032 GroES-like
     IPR013154 ADH_GroES-like
     IPR002364 Quin_OxRdtase/zeta-crystal_CS
     IPR002085 ADH_SF_Zn-type

    Graphical View of Domain Structure for InterPro Entry Q08257

    ProtoNet protein and cluster: Q08257

    2 Blocks protein domains:
    IPB002364 Quinone oxidoreductase/zeta-crystallin
    IPB013154 Alcohol dehydrogenase GroES-like


    UniProtKB/Swiss-Prot: QOR_HUMAN, Q08257
    Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily


    Find genes that share domains with CRYZ           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: QOR_HUMAN, Q08257
    Function: Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer
    process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in
    vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of
    target mRNA species. Enhances the stability of mRNA coding for BCL2. NADPH binding interferes with mRNA binding
    Catalytic activity: NADPH + 2 quinone = NADP(+) + 2 semiquinone

         Genatlas biochemistry entry for CRYZ:
    crystallin,zeta polypeptide (quinone reductase)

         Enzyme Number (IUBMB): EC 1.6.5.51 2

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003730mRNA 3'-UTR binding IDA17497241
    GO:0003960NADPH:quinone reductase activity IDA17497241
    GO:0008270zinc ion binding IEA--
    GO:0016491oxidoreductase activity ----
    GO:0016747transferase activity, transferring acyl groups other than amino-acyl groups ----
         
    Find genes that share ontologies with CRYZ           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for CRYZ:
     Decreased viability of wild-ty  Increased Salmonella enterica  

         1 MGI phenotypic allele for Cryz (no phenotypes)

    Find genes that share phenotypes with CRYZ           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CRYZ
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CRYZ

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CRYZ
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CRYZ

    miRNA
    Products:
        
    miRTarBase miRNAs that target CRYZ:
    hsa-mir-26b-5p (MIRT030176), hsa-mir-1296-5p (MIRT036137)

    Block miRNA regulation of human, mouse, rat CRYZ using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CRYZ
    SwitchGear 3'UTR luciferase reporter plasmidCRYZ 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CRYZ
    Predesigned siRNA for gene silencing in human, mouse, rat CRYZ

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CRYZ

    Clone
    Products:
         
    OriGene clones in human, mouse for CRYZ (see all 23)
    OriGene ORF clones in mouse, rat for CRYZ
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): CRYZ (NM_001134759)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRYZ
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRYZ

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CRYZ
    Browse ESI BIO Cell Lines and PureStem Progenitors for CRYZ 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRYZ


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    QOR_HUMAN, Q08257: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    golgi apparatus4
    mitochondrion2
    nucleus2
    plasma membrane1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005794Golgi apparatus IDA--
    GO:0005829cytosol IDA17497241
    GO:0043231intracellular membrane-bounded organelle IDA--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with CRYZ           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CRYZ
    Interactions:

        Search GeneGlobe Interaction Network for CRYZ

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CRYZ (Q082573 ENSP000003393994) via UniProtKB, MINT, STRING, and/or I2D (see all 64)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CRYAAP024893, ENSP000002915544I2D: score=2 STRING: ENSP00000291554
    MCCP235083, ENSP000003862274I2D: score=1 STRING: ENSP00000386227
    IKBKEQ141643I2D: score=1 
    ACOT7ENSP000003670864STRING: ENSP00000367086
    GPX7ENSP000003546774STRING: ENSP00000354677
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007601visual perception TAS7835889
    GO:0042178xenobiotic catabolic process IDA17497241
    GO:0051289protein homotetramerization IPI17497241
    GO:0055114oxidation-reduction process ----

    Find genes that share ontologies with CRYZ           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CRYZ (QOR)

    7 HMDB Compounds for CRYZ    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adrenochrome o-semiquinoneAdcSq ----
    Dopachrome o-semiquinoneleukodopachrome O-semiquinone radical;DcSq 18766-67-1--
    Leukoaminochromeleucoaminochrome;2,3-dihydro-5,6-dihydroxyindole;5,6-dihydroxyindoline;56DHInn;indoline-5,6-diol;5,6-dihydroxy-2,3-dihydroindole 29539-03-5--
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--
    NADPH2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)53-57-6--
    Noradrenochrome o-semiquinonenAdcSq ----
    Quinone1,4-Benzoquine (see all 25)106-51-4--

    2 DrugBank Compounds for CRYZ    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    DicumarolBis-Hydroxycoumarin (see all 4)66-76-2targetinhibitor17305492 1722672 12882764 10561120 16700548
    2'-Monophosphoadenosine 5'-Diphosphoribose-- --target--17139284 17016423



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for CRYZ gene (4 alternative transcripts): 
    NM_001130042.1  NM_001130043.1  NM_001134759.1  NM_001889.3  

    Unigene Cluster for CRYZ:

    Crystallin, zeta (quinone reductase)
    Hs.83114  [show with all ESTs]
    Unigene Representative Sequence: BX649061
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370872 ENST00000340866 ENST00000492102 ENST00000370871 ENST00000370870
    ENST00000441120 ENST00000417775(uc001dgk.3 uc001dgj.3 uc001dgl.3 uc001dgm.3)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CRYZ using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CRYZ
    SwitchGear 3'UTR luciferase reporter plasmidCRYZ 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CRYZ
    Predesigned siRNA for gene silencing in human, mouse, rat CRYZ
    Clone
    Products:
         
    OriGene clones in human, mouse for CRYZ (see all 23)
    OriGene ORF clones in mouse, rat for CRYZ
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): CRYZ (NM_001134759)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRYZ
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRYZ
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CRYZ
    OriGene qSTAR qPCR primer pairs in human, mouse for CRYZ
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CRYZ
      QuantiTect SYBR Green Assays in human, mouse, rat CRYZ
      QuantiFast Probe-based Assays in human, mouse, rat CRYZ

    Additional mRNA sequence: 

    AB209714.1 AK123469.1 AK128794.1 AK223150.1 AK223201.1 AK314813.1 BC039578.1 BC070058.1 
    BX647883.1 BX649061.1 L13278.1 

    21 DOTS entries:

    DT.317064  DT.91958776  DT.451787  DT.40197655  DT.100795962  DT.121406059  DT.100795957  DT.121406041 
    DT.91760330  DT.100809052  DT.121406021  DT.121406038  DT.121406042  DT.121406070  DT.91760318  DT.91760321 
    DT.91760322  DT.91760323  DT.95170655  DT.95170662  DT.97813930 

    Selected AceView cDNA sequences (see all 243):

    BU632079 BF111971 BG391747 CA445304 BP362209 BU619437 BQ772916 BQ214457 
    BE336715 BX445370 L13278 T28683 AA694443 AW167057 CR620400 BM315099 
    CA395829 AI978806 CA446797 CR614503 AA035180 CD108812 BX647883 CR594192 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CRYZ (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c · 12d
    SP1:                    -     -     -     -     -                                                                 -                                 
    SP2:                                      -     -                                                                 -                                 
    SP3:                    -     -     -     -     -                                                           -     -                                 
    SP4:                                      -     -                             -     -                                                               
    SP5:                    -     -     -     -     -     -     -                 -     -                                                               


    ECgene alternative splicing isoforms for CRYZ

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    CRYZ expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTGTATTGG
    CRYZ Expression
    About this image


    CRYZ expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     NULL (Uncategorized)
             Vascular endothelial growth factor-induced embryoid bodies
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    CRYZ Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CRYZ Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.83114

    UniProtKB/Swiss-Prot: QOR_HUMAN, Q08257
    Tissue specificity: Only very low amounts in the lens

        Custom PCR Arrays for CRYZ
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CRYZ
    OriGene qSTAR qPCR primer pairs in human, mouse for CRYZ
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CRYZ
    QuantiTect SYBR Green Assays in human, mouse, rat CRYZ
    QuantiFast Probe-based Assays in human, mouse, rat CRYZ
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRYZ

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CRYZ gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cryz1 , 5 crystallin, zeta1, 5 79.03(n)1
    81.16(a)1
      3 (79.25 cM)5
    129721  NM_009968.31  NP_034098.11 
     1545967115 
    chicken
    (Gallus gallus)
    Aves CRYZ1 crystallin, zeta (quinone reductase) 67.89(n)
    70.03(a)
      772289  NM_001079763.1  NP_001073231.1 
    lizard
    (Anolis carolinensis)
    Reptilia CRYZ6
    crystallin, zeta (quinone reductase)
    66(a)
    1 ↔ 1
    GL343194.1(2751458-2775533)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.82762 Transcribed sequence with weak similarity to protein more 74.6(n)    CF376815.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.145142 Danio rerio mRNA similar to crystallin, zeta (quinone more 74.95(n)    BC052129.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F39B2.31 , 3 Zinc-binding dehydrogenases3
    F39B2.31
    41(a)3
    50.8(n)1
    43.13(a)1
      I(14796259-14797523)3
    1733461  NM_061176.41  NP_493577.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes (YNL134C)4 Putative protein of unknown function with similarity more   --   14(373581-372451) 855588  NP_014265.1 


    ENSEMBL Gene Tree for CRYZ (if available)
    TreeFam Gene Tree for CRYZ (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for CRYZ gene
    VAT12  ZADH22  VAT1L2  TP53I32  
    4 SIMAP similar genes for CRYZ using alignment to 3 protein entries:     QOR_HUMAN (see all proteins):
    VAT1    VAT1L    TP53I3    DKFZp547P162

    Find genes that share paralogs with CRYZ           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for CRYZ
    PGOHUM00000250724 PGOHUM00000232951


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for CRYZ (see all 761)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1118744041,2
    C--73307375(+) TAGAA-/ATATGTT 4 -- int11Minor allele frequency- AT:0.00CSA 2
    rs108901401,2
    C,F,A,H--73308548(+) AAGGGT/GGTATT 4 -- int15Minor allele frequency- G:0.01EA NS NA 300
    rs108901411,2
    C,F,A,H--73308549(+) AGGGTG/ATATTA 4 -- int12Minor allele frequency- A:0.50NA 4
    rs30414521,2
    C--73327569(+) aaaaa-/A/AA  
            
    attag
    4 -- int11NA 2
    rs1121310031,2
    C--73327673(+) TGAGAT/-GATGC 4 -- int11Minor allele frequency- -:0.00CSA 2
    rs1447899891,2
    C--73327673(+) GAGAG-/C/TATGCC 4 -- int10--------
    rs412892221,2
    --75171132(+) AGAAGC/TGATGA 4 -- ds50010--------
    rs10511771,2
    C,F--75171550(+) TTTAGT/ATCAGA 4 -- ut316Minor allele frequency- A:0.01MN NA CSA 329
    rs14246701,2
    C,F,O,A--75171784(+) TTGAGA/TCAGAT 4 -- ut31 ese35Minor allele frequency- T:0.02MN NA WA 444
    rs133756241,2
    H--75171839(+) TGCTTC/TTGCTC 4 -- ut314Minor allele frequency- T:0.00NS EA 398

    HapMap Linkage Disequilibrium report for CRYZ (75171170 - 75199092 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for CRYZ:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2668367CNV Deletion23128226
    esv2662359CNV Deletion23128226
    nsv1422CNV Insertion18451855
    nsv509346CNV Insertion20534489
    esv21668CNV Gain19812545
    nsv871152CNV Gain21882294
    nsv830259CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CRYZ
    DNA2.0 Custom Variant and Variant Library Synthesis for CRYZ

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 123691    OMIM disorders: --

    2 diseases from the University of Copenhagen DISEASES database for CRYZ:
    Cancer     Interstitial nephritis

    Find genes that share disorders with CRYZ           About GenesLikeMe

    Genetic Association Database (GAD): CRYZ
    Human Genome Epidemiology (HuGE) Navigator: CRYZ (1 document)

    Export disorders for CRYZ gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CRYZ gene, integrated from 10 sources (see all 41):
    (articles sorted by number of sources associating them with CRYZ)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Organization of the human zeta-crystallin/quinone reductase gene (CRYZ). (PubMed id 8088825)1, 2, 9 Gonzalez P.... Zigler J.S. Jr. (Genomics 1994)
    2. {zeta}-Crystallin is a bcl-2 mRNA binding protein involved in bcl-2 overexpression in T-cell acute lymphocytic leukemia. (PubMed id 20103721)1, 2 Lapucci A.... Capaccioli S. (FASEB J. 2010)
    3. Human and yeast zeta-crystallins bind AU-rich elements in RNA. (PubMed id 17497241)1, 2 Fernandez M.R.... Pares X. (Cell. Mol. Life Sci. 2007)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. [Polymorphism of MAO-B gene and NAD(P)H: quinone oxidoreductase gene in Parkinson's disease]. (PubMed id 11295131)1, 4 Shao M....Chen B. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2001)
    7. Molecular cloning and sequencing of zeta-crystallin/quinone reductase cDNA from human liver. (PubMed id 8466529)1, 2 Gonzalez P.... Zigler J.S. Jr. (Biochem. Biophys. Res. Commun. 1993)
    8. Assignment of the zeta-crystallin gene (CRYZ) to human chromosome 1p22-p31 and identification of restriction fragment length polymorphisms. (PubMed id 7835889)1, 9 Heinzmann C....Bateman J.B. (Genomics 1994)
    9. Genome-wide association analysis identifies TYW3/CRYZ and NDST4 loci associated with circulating resistin levels. (PubMed id 22843503)1 Qi Q....Qi L. (Hum. Mol. Genet. 2012)
    10. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 1429 HGNC: 2419 AceView: CRYZ Ensembl:ENSG00000116791 euGenes: HUgn1429
    ECgene: CRYZ H-InvDB: CRYZ

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CRYZ Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CRYZ gene:
    Search GeneIP for patents involving CRYZ

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for CRYZ  
     OriGene qPCR primer pairs and template standards for CRYZ   OriGene Protein Over-expression Lysate for CRYZ  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for CRYZ  
     OriGene qSTAR qPCR primer pairs in human, mouse for CRYZ   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for CRYZ   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CRYZ   OriGene Custom Protein Services for CRYZ  

     
     
     Block miRNA regulation of human, mouse, rat CRYZ using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CRYZ
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CRYZ Predesigned siRNA for gene silencing in human, mouse, rat CRYZ
     QuantiFast Probe-based Assays in human, mouse, rat CRYZ QuantiTect SYBR Green Assays in human, mouse, rat CRYZ
     Custom PCR Arrays for CRYZ Search Chromatin IP Primers for CRYZ
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CRYZ  Search GeneGlobe Interaction Network for CRYZ
     Regulatory tfbs in CRYZ promoter
     GenScript Custom Purified and Recombinant Proteins Services for CRYZ GenScript cDNA clones with any tag delivered in your preferred vector for CRYZ
     GenScript Custom Assay Services for CRYZ GenScript Custom overexpressing Cell Line Services for CRYZ
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for CRYZ (QOR)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CRYZ antibodies
     CRYZ proteins
     CRYZ lysates
     Antibodies for CRYZ
     See all of Abcam's Antibodies, Kits and Proteins for CRYZ
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for CRYZ
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRYZ
     SwitchGear 3'UTR luciferase reporter plasmids for CRYZ
     SwitchGear Promoter luciferase reporter plasmids for CRYZ
     ThermoFisher Antibody for CRYZ
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRYZ
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CRYZ
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CRYZ
     LSBio Antibodies in human, mouse, rat for CRYZ
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for CRYZ
      Search eBioscience for proteins for CRYZ
      Search eBioscience for elisas for CRYZ
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CRYZ gene at Home site.
    Version: 3.12.202 14 Sep 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4