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CRYM Gene

protein-coding   GIFtS: 56
GCID: GC16M021269

Crystallin, Mu

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Crystallin, Mu1 2     Mu-Crystallin Homolog2
Thiomorpholine-Carboxylate Dehydrogenase1 2     NADP-Regulated Thyroid-Hormone Binding Protein2
THBP2 3     EC 1.5.1.253
DFNA402 5     NADP-Regulated Thyroid-Hormone-Binding Protein3
Ketimine Reductase Mu-Crystallin2     

External Ids:    HGNC: 24181   Entrez Gene: 14282   Ensembl: ENSG000001033167   OMIM: 1237405   UniProtKB: Q148943   

Export aliases for CRYM gene to outside databases

Previous GC identifers: GC16M020678 GC16M021278 GC16M021236 GC16M021177 GC16M019805


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CRYM Gene:
Crystallins are separated into two classes: taxon-specific and ubiquitous. The former class is also called
phylogenetically-restricted crystallins. The latter class constitutes the major proteins of vertebrate eye lens
and maintains the transparency and refractive index of the lens. This gene encodes a taxon-specific crystallin
protein that binds NADPH and has sequence similarity to bacterial ornithine cyclodeaminases. The encoded protein
does not perform a structural role in lens tissue, and instead it binds thyroid hormone for possible regulatory
or developmental roles. Mutations in this gene have been associated with autosomal dominant non-syndromic
deafness. Multiple alternatively spliced transcript variants have been found for this gene. (provided by RefSeq,
Mar 2010)

GeneCards Summary for CRYM Gene:
CRYM (crystallin, mu) is a protein-coding gene. Diseases associated with CRYM include deafness, autosomal dominant 40, and familial juvenile hyperuricemic nephropathy. GO annotations related to this gene include NADP binding and protein homodimerization activity.

UniProtKB/Swiss-Prot: CRYM_HUMAN, Q14894
Function: Specifically catalyzes the reduction of imine bonds in brain substrates that may include cystathionine
ketimine (CysK) and lanthionine ketimine (LK). Binds thyroid hormone which is a strong reversible inhibitor.
Presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to
its nuclear receptors

Gene Wiki entry for CRYM Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NC_018927.2  NT_187260.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the CRYM gene promoter:
         GATA-3   HNF-4alpha2   XBP-1   Nkx2-5   Ik-3   C/EBPalpha   GATA-1   GATA-2   AREB6   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CRYM promoter sequence
   Search Chromatin IP Primers for CRYM

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CRYM


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p12.2   Ensembl cytogenetic band:  16p12.2   HGNC cytogenetic band: 16p12.2

CRYM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRYM gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M021269:  view genomic region     (about GC identifiers)

Start:
21,250,195 bp from pter      End:
21,314,404 bp from pter
Size:
64,210 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CRYM_HUMAN, Q14894 (See protein sequence)
Recommended Name: Ketimine reductase mu-crystallin  
Size: 314 amino acids; 33776 Da
Cofactor: NAD or NADP
Subunit: Homodimer
1 PDB 3D structure from and Proteopedia for CRYM:
2I99 (3D)    
Secondary accessions: D5MNX0 Q5HYB7

Explore the universe of human proteins at neXtProt for CRYM: NX_Q14894

Explore proteomics data for CRYM at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CRYM Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001014444.1  NP_001879.1  

    ENSEMBL proteins: 
     ENSP00000459982   ENSP00000460820   ENSP00000219599   ENSP00000460126   ENSP00000461904  
     ENSP00000460510   ENSP00000440227   ENSP00000379341   ENSP00000390928  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR003462 ODC_Mu_crystall
     IPR023401 ODC_N
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q14894

    ProtoNet protein and cluster: Q14894

    1 Blocks protein domain: IPB003462 Ornithine cyclodeaminase/mu-crystallin

    UniProtKB/Swiss-Prot: CRYM_HUMAN, Q14894
    Similarity: Belongs to the ornithine cyclodeaminase family


    CRYM for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CRYM_HUMAN, Q14894
    Function: Specifically catalyzes the reduction of imine bonds in brain substrates that may include cystathionine
    ketimine (CysK) and lanthionine ketimine (LK). Binds thyroid hormone which is a strong reversible inhibitor.
    Presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to
    its nuclear receptors
    Catalytic activity: Thiomorpholine 3-carboxylate + NAD(P)(+) = 3,4-dehydro-thiomorpholine-3-carboxylate + NAD(P)H
    Biophysicochemical properties: Kinetic parameters: KM=47 uM for 3,4-dehydro-thiomorpholine-3-carboxylate (at pH
    5.0 and 37 degrees Celsius); KM=3.6 uM for NADH (at pH 5.0 and 37 degrees Celsius); Vmax=9.6 umol/min/mg enzyme
    with 3,4-dehydro-thiomorpholine-3- carboxylate as substrate (at pH 5.0 and 37 degrees Celsius); pH dependence:
    Optimum pH is 4.5;

         Genatlas biochemistry entry for CRYM:
    crystallin,mu polypeptide

         Enzyme Number (IUBMB): EC 1.5.1.251

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003714transcription corepressor activity IMP11897713
    GO:0004616phosphogluconate dehydrogenase (decarboxylating) activity ----
    GO:0042562hormone binding ----
    GO:0042803protein homodimerization activity IDA12590647
    GO:0047127thiomorpholine-carboxylate dehydrogenase activity IEA--
         
    CRYM for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CRYM:
     Increased G1 DNA content  Synthetic lethal with Ras 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Crym):
     cardiovascular system  endocrine/exocrine gland  growth/size/body  hearing/vestibular/ear  homeostasis/metabolism 

    CRYM for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Crymtm1Sasu for CRYM

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    hsa-miR-205*
    SwitchGear 3'UTR luciferase reporter plasmidCRYM 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CRYM_HUMAN, Q14894: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    plasma membrane4
    cytosol3
    mitochondrion2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA12471561
    GO:0005739mitochondrion IEA--
    GO:0005886plasma membrane ----
    GO:0070062extracellular vesicular exosome IDA19056867

    CRYM for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CRYM
    Interactions:

        Search GeneGlobe Interaction Network for CRYM

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for CRYM (Q148942, 3 ENSP000002195994) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    C7orf25Q9BPX72, 3MINT-8249986 I2D: score=2 
    CDC37Q165432, 3MINT-8250833 I2D: score=2 
    DLG4P783523I2D: score=1 
    PTRH2ENSP000003767584STRING: ENSP00000376758
    PLOD1ENSP000001960614STRING: ENSP00000196061
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IMP11897713
    GO:0006098pentose-phosphate shunt ----
    GO:0007605sensory perception of sound IMP12471561
    GO:0042403thyroid hormone metabolic process IEA--
    GO:0055114oxidation-reduction process ----

    CRYM for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CRYM

    8 Novoseek inferred chemical compound relationships for CRYM gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tetrahydrobiopterin 71.4 31 20018174 (11), 15489553 (5), 9328354 (3), 12160330 (2) (see all 5)
    ornithine 68.3 8 15516582 (2), 15518536 (1), 17242435 (1), 17692531 (1) (see all 7)
    nadph 45.9 2 17242435 (1), 9285773 (1)
    triiodothyronine 34.6 1 17289043 (1)
    thyroxine 26.1 4 15489553 (2), 17289043 (1)
    alanine 21.7 3 15516582 (1), 17242435 (1), 18214971 (1)
    potassium 5.26 2 16740909 (1)
    atp 0 1 17233837 (1)



    CRYM for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CRYM gene (2 alternative transcripts): 
    NM_001014444.2  NM_001888.3  

    Unigene Cluster for CRYM:

    Crystallin, mu
    Hs.924  [show with all ESTs]
    Unigene Representative Sequence: BX648477
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000574448(uc010bwq.1) ENST00000570401 ENST00000219599(uc002dim.3 uc002dil.3)
    ENST00000572113 ENST00000576703 ENST00000571666 ENST00000572914 ENST00000571358
    ENST00000574787 ENST00000543948 ENST00000396023 ENST00000415987
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate CRYM:
    hsa-miR-205*
    SwitchGear 3'UTR luciferase reporter plasmidCRYM 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK290852.1 AK310424.1 BC008398.1 BC018061.1 BX648477.1 L02950.1 U85772.1 

    8 DOTS entries:

    DT.113280  DT.95164008  DT.120657645  DT.87046931  DT.100781760  DT.120657639  DT.40126790  DT.95196460 

    Selected AceView cDNA sequences (see all 90):

    CA944935 T28859 AA662278 BI914956 BQ639878 AI859176 BQ639566 BI860684 
    CD513160 AA936267 NM_001888 L02950 BM709216 BV179762 AI659267 U85772 
    AV703147 CD107892 AI620601 BG400786 BC008398 BM930512 BX452499 BC018061 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CRYM    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8
    SP1:                                            -           -                 -         
    SP2:                    -                       -           -                           
    SP3:                                                                                    
    SP4:                                                                                    


    ECgene alternative splicing isoforms for CRYM

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CRYM expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTACCTTA
    CRYM Expression
    About this image


    CRYM expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 5 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Metanephric Mesenchyme Cells Metanephric Mesenchyme
             Interstitial Stroma
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             Limb Muscle Progenitor Cells Forelimb Myotome
     
     Epithelial Cells
             Fetal Matrix Cells Hair Follicle
    CRYM Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CRYM Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.924

    UniProtKB/Swiss-Prot: CRYM_HUMAN, Q14894
    Tissue specificity: Expressed in neural tissue, muscle and kidney

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRYM

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CRYM gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Crym1 , 5 crystallin, mu1, 5 87.01(n)1
    88.82(a)1
      7 (64.47 cM)5
    129711  NM_016669.11  NP_057878.11 
     1201863805 
    chicken
    (Gallus gallus)
    Aves CRYM1 crystallin, mu 70.09(n)
    73.72(a)
      427008  XM_424610.4  XP_424610.2 
    lizard
    (Anolis carolinensis)
    Reptilia CRYM6
    crystallin, mu
    80(a)
    1 ↔ 1
    AAWZ02036656(10370-23594)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.246952 Xenopus laevis transcribed sequence with weak similarity more 73.62(n)    CB565151.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.224092 Transcribed sequence with moderate similarity to protein more 72.65(n)    BI886818.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG48721 CG4872 49.78(n)
    37.33(a)
      32676  NM_132945.3  NP_573173.2 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G528101 AT5G52810 46.38(n)
    34.78(a)
      835358  NM_124659.1  NP_200093.1 
    rice
    (Oryza sativa)
    Liliopsida Os10g05332001 Os10g0533200 49.12(n)
    39.85(a)
      4349222  NM_001071689.1  NP_001065154.1 


    ENSEMBL Gene Tree for CRYM (if available)
    TreeFam Gene Tree for CRYM (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CRYM (see all 930)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1048945091,2
    Cpathogenic121273255(-) AAATAA/TAACAA 4 * Y --0--------
    rs1048945121,2
    Cpathogenic121273259(-) TGGTAA/CATAAA 4 K T mis10--------
    rs793522481,2
    C,F--21272524(+) GAGCCG/ATGGCT 2 -- ds50011Minor allele frequency- A:0.04EA 120
    rs1890896111,2
    --21272532(+) GCTCAC/TGCCTG 2 -- ds50010--------
    rs1405701061,2
    C--21272688(+) CTACTC/TGTGAG 2 -- ds50010--------
    rs1817480141,2
    --21272693(+) CGTGAA/GGCTAA 2 -- ds50010--------
    rs58161511,2
    C--21272769(+) aaaaaA/-GAGAG 2 -- int1 trp31Minor allele frequency- -:0.00NA 2
    rs1867743521,2
    --21272975(+) TAATAC/GAAGTT 2 -- ds50010--------
    rs745953241,2
    C,F--21273142(+) CATGAT/CAAGCA 2 -- ut311Minor allele frequency- C:0.03WA 118
    rs1422177691,2
    --21273158(+) GGAGAA/GTTCAC 2 -- ut310--------

    HapMap Linkage Disequilibrium report for CRYM (21250195 - 21314404 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for CRYM:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2714068CNV Deletion23290073
    nsv436835CNV Insertion17901297
    nsv526247CNV Loss19592680
    esv34235CNV Gain17911159
    nsv905576CNV Gain21882294
    dgv830e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): CRYM
    Locus Specific Mutation Databases (LSDB): CRYM

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CRYM
    DNA2.0 Custom Variant and Variant Library Synthesis for CRYM

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 123740    OMIM disorders: --

    19 diseases for CRYM:    
    About MalaCards
    deafness, autosomal dominant 40    familial juvenile hyperuricemic nephropathy    brain cancer    deafness, autosomal dominant 4b
    thyroiditis    facioscapulohumeral muscular dystrophy    nonsyndromic deafness    hyperthyroidism
    retinitis pigmentosa    hyperglycemia    muscular dystrophy    cataract
    retinitis    schizophrenia    prostate cancer    prostatitis
    malaria    cerebritis    breast cancer

    2 diseases from the University of Copenhagen DISEASES database for CRYM:
    Facioscapulohumeral muscular dystrophy     Nonsyndromic deafness

    CRYM for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for CRYM gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 6 12160330 (1), 11888886 (1), 19353593 (1)
    cancer 0 2 19353593 (2)

    Human Genome Epidemiology (HuGE) Navigator: CRYM (1 document)

    Export disorders for CRYM gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for CRYM gene, integrated from 10 sources (see all 45):
    (articles sorted by number of sources associating them with CRYM)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mammalian forebrain ketimine reductase identified as mu-crystallin; potential regulation by thyroid hormones. (PubMed id 21332720)1, 2, 3 Hallen A.... Willows R.D. (J. Neurochem. 2011)
    2. Two roles for mu-crystallin: a lens structural protein in diurnal marsupials and a possible enzyme in mammalian retinas. (PubMed id 9285773)1, 2, 9 Segovia L.... Wistow G. (Mol. Vis. 1997)
    3. Crystal structure of human micro-crystallin complexed with NADPH. (PubMed id 17242435)1, 2, 9 Cheng Z.... Gong W. (Protein Sci. 2007)
    4. Mu-crystallin is a mammalian homologue of Agrobacterium ornithine cyclodeaminase and is expressed in human retina. (PubMed id 1384048)1, 2, 9 Kim R.Y.... Wistow G.J. (Proc. Natl. Acad. Sci. U.S.A. 1992)
    5. Purification, molecular cloning, and functional expression of the human nicotinamide-adenine dinucleotide phosphate-regulated thyroid hormone-binding protein. (PubMed id 9328354)1, 2, 9 Vie M.-P.... Blondeau J.-P. (Mol. Endocrinol. 1997)
    6. Localization of the human gene for mu-crystallin to chromosome 16p. (PubMed id 1478656)1, 3, 9 Chen H....Antonarakis S.E. (Genomics 1992)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PubMed id 10493829)1, 2 Loftus B.J.... Adams M.D. (Genomics 1999)
    9. Hyperglycemia induces elevated expression of thyroid hormone binding protein in vivo in kidney and heart and in vitro in mesangial cells. (PubMed id 20018174)1, 9 Al-Kafaji G. and Malik A.N. (Biochem. Biophys. Res. Commun. 2010)
    10. Identification of mu-crystallin as an androgen-regulated gene in human prostate cancer. (PubMed id 19353593)1, 9 Malinowska K....Culig Z. (Prostate 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1428 HGNC: 2418 AceView: CRYM Ensembl:ENSG00000103316 euGenes: HUgn1428
    ECgene: CRYM H-InvDB: CRYM

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CRYM Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CRYM gene:
    Search GeneIP for patents involving CRYM

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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