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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CRYL1 Gene

protein-coding   GIFtS: 53
GCID: GC13M020977

Crystallin, Lambda 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Crystallin, Lambda 11 2     Crystallin, Lamda 12
L-Gulonate 3-Dehydrogenase1 2 3     gul3DH2
Lambda-Crystallin Homolog1 2     lambda-CRY2
crystallin1     CRY3
Lamda 11     EC 1.1.1.453
GDH2     Gul3DH3

External Ids:    HGNC: 182461   Entrez Gene: 510842   Ensembl: ENSG000001654757   OMIM: 6098775   UniProtKB: Q9Y2S23   

Export aliases for CRYL1 gene to outside databases

Previous GC identifers: GC13M018957 GC13M014957 GC13M019907 GC13M018775 GC13M019875 GC13M001781


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CRYL1 Gene:
The uronate cycle functions as an alternative glucose metabolic pathway, accounting for about 5% of daily glucose
catabolism. The product of this gene catalyzes the dehydrogenation of L-gulonate into dehydro-L-gulonate in the
uronate cycle. The enzyme requires NAD(H) as a coenzyme, and is inhibited by inorganic phosphate. A similar gene
in the rabbit is thought to serve a structural role in the lens of the eye. (provided by RefSeq, Jul 2008)

GeneCards Summary for CRYL1 Gene: 
CRYL1 (crystallin, lambda 1) is a protein-coding gene. Diseases associated with CRYL1 include tuberculosis, and hepatocellular carcinoma, and among its related super-pathways are Ascorbate and aldarate metabolism and Metabolism. GO annotations related to this gene include protein homodimerization activity and 3-hydroxyacyl-CoA dehydrogenase activity.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NT_024524.14  NC_018924.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CRYL1 gene promoter:
         GR   AML1a   Pbx1a   GR-beta   SREBP-1c   SREBP-1b   RORalpha2   AREB6   SREBP-1a   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCRYL1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CRYL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CRYL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q12.11   Ensembl cytogenetic band:  13q12.11   HGNC cytogenetic band: 13q11

CRYL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRYL1 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M020977:  view genomic region     (about GC identifiers)

Start:
20,977,806 bp from pter      End:
21,100,012 bp from pter
Size:
122,207 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CRYL1_HUMAN, Q9Y2S2 (See protein sequence)
Recommended Name: Lambda-crystallin homolog  
Size: 319 amino acids; 35419 Da
Subunit: Homodimer
Subcellular location: Cytoplasm (By similarity)
Sequence caution: Sequence=AAD27782.1; Type=Frameshift; Positions=Several; Sequence=AAD27782.1; Type=Miscellaneous
discrepancy; Note=Unknown reasons;
1 PDB 3D structure from and Proteopedia for CRYL1:
3F3S (3D)    
Secondary accessions: A0PJ43 B3KN92 Q0VDI1 Q7Z4Z9 Q9P0G7
Alternative splicing: 2 isoforms:  Q9Y2S2-1   Q9Y2S2-2   

Explore the universe of human proteins at neXtProt for CRYL1: NX_Q9Y2S2

Explore proteomics data for CRYL1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y2S2

  • CRYL1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CRYL1 Protein Expression
    REFSEQ proteins: NP_057058.2  
    ENSEMBL proteins: 
     ENSP00000298248   ENSP00000372262  

    Human Recombinant Protein Products for CRYL1: 
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol ISS--

    CRYL1 for ontologies           About GeneDecksing



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    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/7 InterPro protein domains (see all 7):
     IPR008927 6-PGluconate_DH_C-like
     IPR006108 3HC_DH_C
     IPR013328 DH_multihelical
     IPR006176 3-OHacyl-CoA_DH_NAD-bd
     IPR006180 3-OHacyl-CoA_DH_CS

    Graphical View of Domain Structure for InterPro Entry Q9Y2S2

    ProtoNet protein and cluster: Q9Y2S2

    1 Blocks protein domain: IPB006180 3-hydroxyacyl-CoA dehydrogenase

    UniProtKB/Swiss-Prot: CRYL1_HUMAN, Q9Y2S2
    Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family


    CRYL1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CRYL1_HUMAN, Q9Y2S2
    Catalytic activity: L-gulonate + NAD(+) = 3-dehydro-L-gulonate + NADH
    Enzyme regulation: Inhibited by malonate
    Biophysicochemical properties: Kinetic parameters: KM=0.01 mM for NAD; KM=0.0008 mM for NADH;

         Enzyme Number (IUBMB): EC 1.1.1.451

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:00038573-hydroxyacyl-CoA dehydrogenase activity IEA--
    GO:0016491oxidoreductase activity ----
    GO:0042803protein homodimerization activity IPI15809331
    GO:0050104L-gulonate 3-dehydrogenase activity IDA15809331
    GO:0070403NAD+ binding IDA15809331
         
    CRYL1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CRYL1:
     Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

         1 MGI phenotypic allele for Cryl1 (no phenotypes)

    CRYL1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CRYL1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CRYL1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CRYL1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CRYL1 

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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate CRYL1:
    hsa-miR-548p hsa-miR-3662
    SwitchGear 3'UTR luciferase reporter plasmidCRYL1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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                         Customized lentivirus expression plasmids for stable overexpression of CRYL1 

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    Search LifeMap BioReagents cell lines for CRYL1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRYL1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CRYL1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Glucuronidation
    Pentose and glucuronate interconversions0.61
    2Metabolism
    Metabolic pathways0.40
    3D-glucuronate degradation I
    D-glucuronate degradation I

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for CRYL1
        D-glucuronate degradation I


    2         Kegg Pathways  (Kegg details for CRYL1):
        Pentose and glucuronate interconversions
    Metabolic pathways


    CRYL1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CRYL1

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5 Interacting proteins for CRYL1 (Q9Y2S23 ENSP000002982484) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EPS8L2Q9H6S33I2D: score=4 
    GLI2P100703I2D: score=4 
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    ABCC6ENSP000002055574STRING: ENSP00000205557
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006631fatty acid metabolic process IEA--
    GO:0055114oxidation-reduction process ----

    CRYL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CRYL1

    2 HMDB Compounds for CRYL1    About this table
    CompoundSynonyms CAS #PubMed Ids
    (S)-3-Hydroxyhexadecanoyl-CoA(S)-3-hydroxyhexadecanoyl-coenzyme A (see all 14)35106-50-4--
    Acetoacetyl-CoA3-acetoacetyl-CoA (see all 9)1420-36-6--

    Search CenterWatch for drugs/clinical trials and news about CRYL1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CRYL1 gene: 
    NM_015974.2  

    Unigene Cluster for CRYL1:

    Crystallin, lambda 1
    Hs.370703  [show with all ESTs]
    Unigene Representative Sequence: BC071810
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000298248(uc001une.3 uc001unf.3) ENST00000382812(uc001ung.3)
    ENST00000480748(uc010tcp.1)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CRYL1
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate CRYL1:
    hsa-miR-548p hsa-miR-3662
    SwitchGear 3'UTR luciferase reporter plasmidCRYL1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CRYL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CRYL1
    Clone
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    OriGene clones in human, mouse for CRYL1 (see all 6)
    OriGene ORF clones in mouse, rat for CRYL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CRYL1 (NM_015974)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRYL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRYL1
    Sirion Biotech Customized lentivirus for stable overexpression of CRYL1 
                         Customized lentivirus expression plasmids for stable overexpression of CRYL1 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CRYL1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CRYL1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CRYL1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRYL1

    Additional mRNA sequence: 

    AF077049.1 AF160216.1 AK024041.1 AK301605.1 BC008562.2 BC071810.1 BC119660.1 BC119661.1 

    12 DOTS entries:

    DT.118335  DT.100792105  DT.99992367  DT.95189837  DT.95113696  DT.95189831  DT.100807964  DT.120792710 
    DT.91766486  DT.120792701  DT.95189835  DT.120792746 

    24/205 AceView cDNA sequences (see all 205):

    AK024041 BI518672 BI093022 BQ006686 BU733218 AI474970 AU143281 CR623496 
    AI273018 CR617362 CR592394 CR591361 BF724794 CA395938 AA299521 AW517301 
    BI834560 BM707684 BU076223 AI719093 BM923221 AW150974 AW512309 BM786203 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CRYL1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10
    SP1:              -     -                 -                                       
    SP2:              -                       -                                       
    SP3:                                                                              
    SP4:                                                                              


    ECgene alternative splicing isoforms for CRYL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CRYL1 expression in normal human tissues (normalized intensities)      CRYL1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAATATGTG
    CRYL1 Expression
    About this image


    CRYL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Kidney (Urinary System)    fully expand to see all 5 entries
             Loop of Henle Cells Loop of Henle
             Proximal Tubule
     
     Nose (Sensory Organs)    fully expand to see all 3 entries
             sensory organ/nose/nasal cavity   
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Hindgut
     
     Thymus (Hematopoietic System)
             Thymus
     
     Melanocytes (Integumentary System)
             Human EpiDermal Melanocytes-medium (HEM-m)   

    See CRYL1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CRYL1

    SOURCE GeneReport for Unigene cluster: Hs.370703

    UniProtKB/Swiss-Prot: CRYL1_HUMAN, Q9Y2S2
    Tissue specificity: Widely expressed, with highest levels in liver and kidney

        SABiosciences Expression via Pathway-Focused PCR Array including CRYL1: 
              Hepatotoxicity in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRYL1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRYL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CRYL1 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cryl11 , 5 crystallin, lambda 11, 5 82.03(n)1
    84.01(a)1
      14 (30.10 cM)5
    686311  NM_030004.31  NP_084280.21 
     572750345 
    chicken
    (Gallus gallus)
    Aves CRYL11 crystallin, lambda 1 68.61(n)
    66.79(a)
      418953  NM_001030830.1  NP_001026001.1 
    lizard
    (Anolis carolinensis)
    Reptilia CRYL16
    crystallin, lambda 1
    62(a)
    1 ↔ 1
    3(187420289-187445987)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.41822 Transcribed sequence with weak similarity to protein more 69.29(n)    AL852853.2 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.130382 Transcribed sequence with weak similarity to protein more 74.21(n)    57087549 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG99141 , 3 CG99141 46(a)
    (best of 2)3
    54.9(n)1
    52.29(a)1
      14B113
    325921  NM_132886.21  NP_573114.21 
    worm
    (Caenorhabditis elegans)
    Secernentea Y71F9B.93   -- 36(a)   I(2759075-2760983)   --


    ENSEMBL Gene Tree for CRYL1 (if available)
    TreeFam Gene Tree for CRYL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2852 SNPs in CRYL1 are shown (see all 2852)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1929018651,2
    --20977367(+) GGCTGC/GGAAGT 1 -- ds50010--------
    rs170816471,2
    C,F,H--20977507(+) TTGAGT/CGTTGG 1 -- ds500117Minor allele frequency- C:0.05NA NS EA CSA WA 1210
    rs1152035231,2
    F--20977508(+) TGAGTG/ATTGGA 1 -- ds50011Minor allele frequency- A:0.09WA 118
    rs1142495111,2
    F--20977544(+) TTTGGT/GGCCTT 1 -- ds50011Minor allele frequency- G:0.01WA 118
    rs768107191,2
    C,F--20977597(+) GTGATG/ATTTCC 1 -- ds50012Minor allele frequency- A:0.04WA NA 238
    rs1175457981,2
    C,F--20977608(+) CAAACA/GTCATC 1 -- ds50011Minor allele frequency- G:0.01NA 120
    rs1153738711,2
    C,F--20977653(+) TCTGGG/AAAAAG 1 -- ds50011Minor allele frequency- A:0.01WA 118
    rs731608261,2
    C,F--20977667(+) ACATTT/GCTGGA 1 -- ds50013Minor allele frequency- G:0.09CSA WA EA 240
    rs1835530991,2
    --20977754(+) ATGCCA/GGTCAT 1 -- ds50010--------
    rs1154345391,2
    C,F--20977844(+) TAAGCG/ATTAGC 1 -- ut311Minor allele frequency- A:0.02WA 118

    HapMap Linkage Disequilibrium report for CRYL1 (20977806 - 21100012 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/13 variations for CRYL1 (see all 13):    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv240e201CNV Deletion23290073
    esv2747066CNV Deletion23290073
    esv2747062CNV Deletion23290073
    esv1659805CNV Insertion17803354
    esv2751132CNV Loss17911159
    dgv1555n71CNV Loss21882294
    nsv818947CNV Loss17921354
    dgv221n27CNV Loss19166990
    dgv1554n71CNV Loss21882294
    esv34984CNV Loss17911159

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609877    OMIM disorders: --

    2 diseases for CRYL1:    About MalaCards
    tuberculosis    hepatocellular carcinoma


    CRYL1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CRYL1

    Export disorders for CRYL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CRYL1 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with CRYL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human CRYL1, a novel enzyme-crystallin overexpressed in liver and kidney and downregulated in 58% of liver cancer tissues from 60 Chinese patients, and four new homologs from other mammalians. (PubMed id 12527201)1, 2, 3, 9 Chen J....Zhao S. (2003)
    2. Structural and functional characterization of rabbit and human L-gulonate 3-dehydrogenase. (PubMed id 15809331)1, 2, 9 Ishikura S....Hara A. (2005)
    3. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (2012)
    6. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    7. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51084 HGNC: 18246 AceView: CRYL1 Ensembl:ENSG00000165475 euGenes: HUgn51084
    ECgene: CRYL1 Kegg: 51084 H-InvDB: CRYL1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CRYL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CRYL1 gene:
    Search GeneIP for patents involving CRYL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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