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Aliases for CRYL1 Gene

Aliases for CRYL1 Gene

  • Crystallin Lambda 1 2 3 5
  • L-Gulonate 3-Dehydrogenase 2 3 4
  • Lambda-Crystallin Homolog 2 3
  • Crystallin, Lamda 1 2 3
  • Gul3DH 3 4
  • Testicular Tissue Protein Li 44 3
  • Epididymis Luminal Protein 30 3
  • Crystallin, Lambda 1 2
  • EC 4
  • Lambda-CRY 3
  • HEL30 3
  • GDH 3
  • CRY 4

External Ids for CRYL1 Gene

Previous GeneCards Identifiers for CRYL1 Gene

  • GC13M018957
  • GC13M014957
  • GC13M019907
  • GC13M018775
  • GC13M019875
  • GC13M020977
  • GC13M001781

Summaries for CRYL1 Gene

Entrez Gene Summary for CRYL1 Gene

  • The uronate cycle functions as an alternative glucose metabolic pathway, accounting for about 5% of daily glucose catabolism. The product of this gene catalyzes the dehydrogenation of L-gulonate into dehydro-L-gulonate in the uronate cycle. The enzyme requires NAD(H) as a coenzyme, and is inhibited by inorganic phosphate. A similar gene in the rabbit is thought to serve a structural role in the lens of the eye. [provided by RefSeq, Jul 2008]

GeneCards Summary for CRYL1 Gene

CRYL1 (Crystallin Lambda 1) is a Protein Coding gene. Among its related pathways are Metabolism and Porphyrin and chlorophyll metabolism. GO annotations related to this gene include protein homodimerization activity and NAD+ binding.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRYL1 Gene

Genomics for CRYL1 Gene

Regulatory Elements for CRYL1 Gene

Enhancers for CRYL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13F020489 0.5 ENCODE 29.6 +36.5 36487 0.1 CTCF PKNOX1 SMC3 RAD21 CRYL1 EEF1AKMT1 MIR4499
GH13F020494 1 Ensembl ENCODE 23.3 +30.0 30031 1.9 PKNOX1 ARID4B SIN3A YY1 SLC30A9 ZNF143 FOS DEK ZHX2 REST CRYL1 EEF1AKMT1 MIR4499
GH13F020474 1.1 FANTOM5 Ensembl ENCODE 22.5 +49.9 49866 3.2 TBL1XR1 INSM2 FEZF1 ZNF2 EGR1 SCRT2 ETV6 CREM EGR2 CBFB CRYL1 IFT88 MIR4499
GH13F020517 1.2 Ensembl ENCODE 19.5 +3.2 3232 9.4 ATF1 ARID4B SIN3A DMAP1 ZNF48 YY1 ZNF766 GLIS2 ZNF143 FOS CRYL1 MIR4499
GH13F020546 1 Ensembl ENCODE 17.3 -21.3 -21306 2.4 SOX13 DRAP1 ZNF146 SAP130 ZNF175 ARID4B ZMYM3 CEBPG ZNF644 RAD21 CRYL1 IFT88 EEF1AKMT1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CRYL1 on UCSC Golden Path with GeneCards custom track

Promoters for CRYL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000054235 173 2201 ARID4B SIN3A DMAP1 ZNF48 YY1 GLIS2 ZNF143 SP3 MIER2 MIER3

Genomic Location for CRYL1 Gene

20,403,667 bp from pter
20,525,873 bp from pter
122,207 bases
Minus strand

Genomic View for CRYL1 Gene

Genes around CRYL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRYL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRYL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRYL1 Gene

Proteins for CRYL1 Gene

  • Protein details for CRYL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Lambda-crystallin homolog
    Protein Accession:
    Secondary Accessions:
    • A0PJ43
    • B3KN92
    • Q0VDI1
    • Q7Z4Z9
    • Q9P0G7

    Protein attributes for CRYL1 Gene

    319 amino acids
    Molecular mass:
    35419 Da
    Quaternary structure:
    • Homodimer.
    • Sequence=AAD27782.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=AAD27782.1; Type=Miscellaneous discrepancy; Note=Unknown reasons.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CRYL1 Gene

    Alternative splice isoforms for CRYL1 Gene


neXtProt entry for CRYL1 Gene

Post-translational modifications for CRYL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CRYL1 Gene

No data available for DME Specific Peptides for CRYL1 Gene

Domains & Families for CRYL1 Gene

Suggested Antigen Peptide Sequences for CRYL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
  • Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
genes like me logo Genes that share domains with CRYL1: view

No data available for Gene Families for CRYL1 Gene

Function for CRYL1 Gene

Molecular function for CRYL1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.01 mM for NAD {ECO:0000269 PubMed:15809331}; KM=0.0008 mM for NADH {ECO:0000269 PubMed:15809331};
UniProtKB/Swiss-Prot CatalyticActivity:
L-gulonate + NAD(+) = 3-dehydro-L-gulonate + NADH.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by malonate.

Enzyme Numbers (IUBMB) for CRYL1 Gene

Gene Ontology (GO) - Molecular Function for CRYL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity IEA --
GO:0016491 oxidoreductase activity IEA --
GO:0042803 protein homodimerization activity IPI 15809331
GO:0050104 L-gulonate 3-dehydrogenase activity EXP,IDA 15809331
GO:0070403 NAD+ binding IDA 15809331
genes like me logo Genes that share ontologies with CRYL1: view
genes like me logo Genes that share phenotypes with CRYL1: view

Animal Model Products

miRNA for CRYL1 Gene

miRTarBase miRNAs that target CRYL1

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CRYL1

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CRYL1 Gene

Localization for CRYL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRYL1 Gene


Subcellular locations from

Jensen Localization Image for CRYL1 Gene COMPARTMENTS Subcellular localization image for CRYL1 gene
Compartment Confidence
cytosol 5
extracellular 5
golgi apparatus 5
nucleus 5
plasma membrane 5
mitochondrion 2

Gene Ontology (GO) - Cellular Components for CRYL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA,IDA --
GO:0005794 Golgi apparatus IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CRYL1: view

Pathways & Interactions for CRYL1 Gene

genes like me logo Genes that share pathways with CRYL1: view

Pathways by source for CRYL1 Gene

Gene Ontology (GO) - Biological Process for CRYL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006631 fatty acid metabolic process IEA --
GO:0019640 glucuronate catabolic process to xylulose 5-phosphate TAS --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with CRYL1: view

No data available for SIGNOR curated interactions for CRYL1 Gene

Drugs & Compounds for CRYL1 Gene

(3) Drugs for CRYL1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Acetoacetyl-CoA Experimental Pharma 0
NAD Pharma Full agonist, Agonist 0
NADH Nutra 0

(4) Additional Compounds for CRYL1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (S)-3-hydroxyhexadecanoyl-coenzyme A
  • (S)-3-hydroxypalmitoyl-coenzyme A
  • b-Hydroxypalmitoyl-CoA
  • b-Hydroxypalmitoyl-Coenzyme A
  • beta-Hydroxypalmitoyl-CoA
  • 3-Dehydro-L-gulonic acid
  • L-Xylo-hex-3-ulosonic acid
Gulonic acid
  • D-Gulonate
  • D-Gulonic acid
  • Gulonate
  • L-Gulonate
  • L-Gulonic acid
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
genes like me logo Genes that share compounds with CRYL1: view

Transcripts for CRYL1 Gene

Unigene Clusters for CRYL1 Gene

Crystallin, lambda 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CRYL1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CRYL1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10
SP1: - - -
SP2: - -

Relevant External Links for CRYL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CRYL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CRYL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CRYL1 Gene

This gene is overexpressed in Kidney - Cortex (x5.3) and Liver (x4.6).

Protein differential expression in normal tissues from HIPED for CRYL1 Gene

This gene is overexpressed in Kidney (11.4), Liver, secretome (8.7), and Liver (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CRYL1 Gene

Protein tissue co-expression partners for CRYL1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CRYL1 Gene:


SOURCE GeneReport for Unigene cluster for CRYL1 Gene:


mRNA Expression by UniProt/SwissProt for CRYL1 Gene:

Tissue specificity: Widely expressed, with highest levels in liver and kidney.
genes like me logo Genes that share expression patterns with CRYL1: view

Primer Products

Orthologs for CRYL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CRYL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CRYL1 34 35
  • 99.37 (n)
(Canis familiaris)
Mammalia CRYL1 34 35
  • 84.85 (n)
(Rattus norvegicus)
Mammalia Cryl1 34
  • 82.65 (n)
(Mus musculus)
Mammalia Cryl1 34 16 35
  • 82.03 (n)
(Bos Taurus)
Mammalia CRYL1 34 35
  • 77.39 (n)
(Monodelphis domestica)
Mammalia CRYL1 35
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia CRYL1 35
  • 73 (a)
(Gallus gallus)
Aves CRYL1 34 35
  • 68.61 (n)
(Anolis carolinensis)
Reptilia CRYL1 35
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cryl1 34
  • 65.7 (n)
Str.4182 34
(Danio rerio)
Actinopterygii cryl1 34 35
  • 59.96 (n)
Dr.13038 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1375 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP013544 34
  • 56.43 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG9914 36 34 35
  • 54.83 (n)
CG10131 36 35
  • 41 (a)
(Caenorhabditis elegans)
Secernentea Y71F9B.9 36 35
  • 36 (a)
Species where no ortholog for CRYL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CRYL1 Gene

Gene Tree for CRYL1 (if available)
Gene Tree for CRYL1 (if available)

Paralogs for CRYL1 Gene

No data available for Paralogs for CRYL1 Gene

Variants for CRYL1 Gene

Sequence variations from dbSNP and Humsavar for CRYL1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs10162125 -- 20,455,302(+) agcta(C/T)accat intron-variant
rs10162275 -- 20,467,652(+) cccat(A/C)gctac intron-variant
rs10454563 -- 20,463,143(+) CAGAG(A/G)AGACC intron-variant
rs10459364 -- 20,524,110(+) CAGCC(A/G)GGTAT intron-variant
rs10459365 -- 20,525,979(+) CACAC(C/G)GCGCG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CRYL1 Gene

Variant ID Type Subtype PubMed ID
dgv1612n100 CNV loss 25217958
dgv221n27 CNV loss 19166990
dgv3072n54 CNV loss 21841781
dgv3075n54 CNV loss 21841781
dgv959e59 CNV duplication 20981092
esv1659805 CNV insertion 17803354
esv27122 CNV gain 19812545
esv2751132 CNV loss 17911159
esv2759925 CNV loss 17122850
esv34984 CNV loss 17911159
esv3631430 CNV loss 21293372
esv3631431 CNV loss 21293372
esv3892301 CNV loss 25118596
esv3892302 CNV loss 25118596
esv7898 CNV gain 19470904
nsv1046946 CNV gain 25217958
nsv1078303 OTHER inversion 25765185
nsv1124860 CNV deletion 24896259
nsv1140246 OTHER inversion 24896259
nsv1151319 CNV insertion 26484159
nsv1151909 OTHER inversion 26484159
nsv818947 CNV loss 17921354
nsv952523 CNV deletion 24416366

Variation tolerance for CRYL1 Gene

Residual Variation Intolerance Score: 64.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.99; 20.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CRYL1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRYL1 Gene

Disorders for CRYL1 Gene

Relevant External Links for CRYL1

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CRYL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CRYL1 Gene

Publications for CRYL1 Gene

  1. Human CRYL1, a novel enzyme-crystallin overexpressed in liver and kidney and downregulated in 58% of liver cancer tissues from 60 Chinese patients, and four new homologs from other mammalians. (PMID: 12527201) Chen J. … Zhao S. (Gene 2003) 2 3 4 22 64
  2. Structural and functional characterization of rabbit and human L- gulonate 3-dehydrogenase. (PMID: 15809331) Ishikura S. … Hara A. (J. Biochem. 2005) 3 4 22 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 3 4 64
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64

Products for CRYL1 Gene

Sources for CRYL1 Gene

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