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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CRYL1 Gene

protein-coding GIFtS: 53
GCID: GC13M020977

crystallin, lambda 1

Explore 5 diseases affiliated with
CRYL1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Crystallin, Lambda 1¹ ²		Crystallin, Lamda 1²
GDH¹ ²		Gul3DH³
Lambda-CRY¹		Lambda-Crystallin Homolog²
L-Gulonate 3-Dehydrogenase² ³		CRY³
MGC149525¹		EC 1.1.1.45³
MGC149526¹		Gul3DH³

External Ids:	HGNC: 18246¹	Entrez Gene: 51084²	Ensembl: ENSG00000165475⁷	OMIM: 609877⁵	UniProtKB: Q9Y2S2³

Export aliases for CRYL1 gene to outside databases

Previous GC identifers: GC13M018957 GC13M014957 GC13M019907 GC13M018775 GC13M019875 GC13M001781

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CRYL1:

The uronate cycle functions as an alternative glucose metabolic pathway, accounting for about 5% of daily glucose

catabolism. The product of this gene catalyzes the dehydrogenation of L-gulonate into dehydro-L-gulonate in the

uronate cycle. The enzyme requires NAD(H) as a coenzyme, and is inhibited by inorganic phosphate. A similar gene in

the rabbit is thought to serve a structural role in the lens of the eye. (provided by RefSeq, Jul 2008)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000013.10 NC_018924.1 NT_024524.14

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CRYL1 gene promoter:
GR AML1a Pbx1a GR-beta SREBP-1c SREBP-1b RORalpha2 AREB6 SREBP-1a GR-alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CRYL1 promoter sequence

Search SABiosciences Chromatin IP Primers for CRYL1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CRYL1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q12.11 Ensembl cytogenetic band: 13q12.11 HGNC cytogenetic band: 13q11

CRYL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRYL1 gene location

GeneLoc information about chromosome 13 GeneLoc Exon Structure

GeneLoc location for GC13M020977: view genomic region (about GC identifiers)

Start:	20,977,806 bp from pter	End:	21,100,012 bp from pter
Size:	122,207 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CRYL1_HUMAN, Q9Y2S2 (See protein sequence)

Recommended Name: Lambda-crystallin homolog

Size: 319 amino acids; 35419 Da

Subunit: Homodimer

Subcellular location: Cytoplasm (By similarity)

Sequence caution: Sequence=AAD27782.1; Type=Frameshift; Positions=Several; Sequence=AAD27782.1; Type=Miscellaneous

discrepancy; Note=Unknown reasons;

1 PDB 3D structure from and Proteopedia for CRYL1:

3F3S (3D)

Secondary accessions: A0PJ43 B3KN92 Q0VDI1 Q7Z4Z9 Q9P0G7

Alternative splicing: 2 isoforms: Q9Y2S2-1 Q9Y2S2-2

Explore the universe of human proteins at neXtProt for CRYL1: NX_Q9Y2S2

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9Y2S2

CRYL1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_057058.2

ENSEMBL proteins:

ENSP00000298248 ENSP00000372262

Human Recombinant Protein Products for CRYL1:

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	Uscn Proteins for CRYL1

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	ISS	--

CRYL1 for ontologies About GeneDecksing

CRYL1 Antibody Products:

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	Uscn ELISAs and CLIAs for CRYL1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CRYL1 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR008927 6-PGluconate_DH_C-like

IPR006108 3HC_DH_C

IPR013328 DH_multihelical

IPR006176 3-OHacyl-CoA_DH_NAD-bd

IPR006180 3-OHacyl-CoA_DH_CS

Graphical View of Domain Structure for InterPro Entry Q9Y2S2

ProtoNet protein and cluster: Q9Y2S2

1 Blocks protein family: IPB006180 3-hydroxyacyl-CoA dehydrogenase

UniProtKB/Swiss-Prot: CRYL1_HUMAN, Q9Y2S2

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CRYL1_HUMAN, Q9Y2S2

Catalytic activity: L-gulonate + NAD(+) = 3-dehydro-L-gulonate + NADH

Enzyme regulation: Inhibited by malonate

Biophysicochemical properties: Kinetic parameters: KM=0.01 mM for NAD; KM=0.0008 mM for NADH;

Enzyme Number (IUBMB): EC 1.1.1.45¹

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003857	3-hydroxyacyl-CoA dehydrogenase activity	IEA	--
GO:0042803	protein homodimerization activity	IPI	15809331
GO:0050104	L-gulonate 3-dehydrogenase activity	IDA	15809331
GO:0070403	NAD+ binding	IDA	15809331

CRYL1 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for CRYL1:

Increased gamma-H2AX phosphory

Synthetic lethal with Ras

1 MGI phenotypic allele

for Cryl1 (no phenotypes)

CRYL1 for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CRYL1

miRNA Products:		OriGene 3'-UTR Clone: CRYL1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CRYL1
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate CRYL1:
		hsa-miR-548p hsa-miR-3662
		SwitchGear 3'UTR luciferase reporter plasmid: CRYL1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CRYL1 (see all 7) OriGene shRNA RFP: CRYL1 OriGene siRNA: CRYL1
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Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for CRYL1
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		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CRYL1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CRYL1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRYL1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

D-glucuronate degradation I

D-glucuronate degradation I

1.00

Pentose and glucuronate interconversions

Pentose and glucuronate interconversions

1.00

Metabolism

Metabolic pathways

0.38

Pathway sources
See GeneCards unified pathways
Show all pathways

1 BioSystems Pathway for CRYL1

D-glucuronate degradation I

2 Kegg Pathways (Kegg details for CRYL1):

	Pentose and glucuronate interconversions
	Metabolic pathways

CRYL1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CRYL1

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

5 Interacting proteins for CRYL1 (Q9Y2S2³ ENSP00000298248⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
EPS8L2	Q9H6S3³	I2D: score=4
GLI2	P10070³	I2D: score=4
ELAVL1	ENSP00000385269⁴	STRING: ENSP00000385269
ABCC6	ENSP00000205557⁴	STRING: ENSP00000205557
UBC	ENSP00000344818⁴	STRING: ENSP00000344818

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006631	fatty acid metabolic process	IEA	--

CRYL1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CRYL1

2 HMDB Compounds for CRYL1 About this table

Compound	Synonyms	CAS #	PubMed Ids
(S)-3-Hydroxyhexadecanoyl-CoA	(S)-3-hydroxyhexadecanoyl-coenzyme A (see all 14)	35106-50-4	--
Acetoacetyl-CoA	3-acetoacetyl-CoA (see all 9)	1420-36-6	--

Search CenterWatch for drugs/clinical trials and news about CRYL1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CRYL1 gene:

NM_015974.2

Unigene Cluster for CRYL1:

Crystallin, lambda 1

Hs.370703 [show with all ESTs]

Unigene Representative Sequence: BC071810

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000298248(uc001une.3 uc001unf.3) ENST00000382812(uc001ung.3)

ENST00000480748(uc010tcp.1)

miRNA Products:		OriGene 3'-UTR Clone: CRYL1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CRYL1
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate CRYL1:
		hsa-miR-548p hsa-miR-3662
		SwitchGear 3'UTR luciferase reporter plasmid: CRYL1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CRYL1 (see all 7) OriGene shRNA RFP: CRYL1 OriGene siRNA: CRYL1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CRYL1
		Sirion Biotech Custom design and validation of potent shRNA sequences against CRYL1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CRYL1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CRYL1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CRYL1 (NM_015974)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRYL1
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Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CRYL1 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CRYL1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRYL1

Additional cDNA sequence:

AF077049.1 AF160216.1 AK024041.1 AK301605.1 BC008562.2 BC071810.1 BC119660.1 BC119661.1

12 DOTS entries:

DT.118335 DT.100792105 DT.99992367 DT.95189837 DT.95113696 DT.95189831 DT.100807964 DT.120792710

DT.91766486 DT.120792701 DT.95189835 DT.120792746

24/205 AceView cDNA sequences (see all 205):

AI273018 BM707684 BU733218 CA395938 BI518672 CR592394 AW517301 BI093022

BF724794 CR591361 AI474970 BQ006686 BI834560 CR617362 CR623496 AK024041

AA299521 AU143281 AF160216 CB215554 BG707424 CK001748 AV721277 CD559082

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for CRYL1 About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6a	·	6b	^	7	^	8a	·	8b	^	9	^	10
SP1:					-		-						-
SP2:					-								-
SP3:
SP4:

ECgene alternative splicing isoforms for CRYL1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CRYL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTAATATGTG

About this image

CRYL1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Gut Tube

Hindgut

Hindgut Endoderm Cells

Endoderm

Gut Tube

Midgut

Midgut Endoderm Cells

Endoderm

Kidney

Proximal Tubule Cells

Kidney

Liver

Liver Lobule

Periportal Hepatocytes

Liver

Gut Tube

Gut Tube

Kidney

Kidney

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)

Endothelium

See CRYL1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CRYL1

SOURCE GeneReport for Unigene cluster: Hs.370703

UniProtKB/Swiss-Prot: CRYL1_HUMAN, Q9Y2S2

Tissue specificity: Widely expressed, with highest levels in liver and kidney

SABiosciences Expression via Pathway-Focused PCR Array including CRYL1:

Hepatotoxicity in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRYL1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for CRYL1 gene from 6/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CRYL1¹	crystallin, lambda 1	68.61(n) 66.79(a)		418953 NM_001030830.1 NP_001026001.1
lizard (Anolis carolinensis)	Reptilia	CRYL1⁶	--	69(a)	1 ↔ 1	3(187424038-187438773)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.4182²	Transcribed sequence with weak similarity to protein more	69.29(n)		AL852853.2
zebrafish (Danio rerio)	Actinopterygii	Dr.13038²	Transcribed sequence with weak similarity to protein more	74.21(n)		57087549
fruit fly (Drosophila melanogaster)	Insecta	CG9914^{1 , 3}	CG9914¹	46(a) (best of 2)³ 54.9(n)¹ 52.29(a)¹		14B11³ 32592¹ NM_132886.2¹ NP_573114.2¹
worm (Caenorhabditis elegans)	Secernentea	Y71F9B.9³	--	36(a)		I(2759075-2760983) --

ENSEMBL Gene Tree for CRYL1 (if available)
TreeFam Gene Tree for CRYL1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 13 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs192901865^1,2		--	20977367(+)	`GGCTGC/GGAAGT`	1	--	ds500¹		0	--	--	--	--
rs17081647^1,2	C,F,H	--	20977507(+)	`TTGAGT/CGTTGG`	1	--	ds500¹		17		NA NS EA CSA WA	1210
rs115203523^1,2	F	--	20977508(+)	`TGAGTG/ATTGGA`	1	--	ds500¹		1		WA	118
rs114249511^1,2		--	20977544(+)	`TTTGGT/GGCCTT`	1	--	ds500¹		1		WA	118
rs76810719^1,2	C,F	--	20977597(+)	`GTGATG/ATTTCC`	1	--	ds500¹		2		WA NA	238
rs117545798^1,2		--	20977608(+)	`CAAACA/GTCATC`	1	--	ds500¹		1		NA	120
rs115373871^1,2		--	20977653(+)	`TCTGGG/AAAAAG`	1	--	ds500¹		1		WA	118
rs73160826^1,2	C	--	20977667(+)	`ACATTT/GCTGGA`	1	--	ds500¹		3		CSA WA EA	240
rs183553099^1,2		--	20977754(+)	`ATGCCA/GGTCAT`	1	--	ds500¹		0	--	--	--	--
rs115434539^1,2	C,F	--	20977844(+)	`TAAGCG/ATTAGC`	1	--	ut3¹		1		WA	118

HapMap Linkage Disequilibrium report for CRYL1 (20977806 - 21100012 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 8 variations for CRYL1
6 CNVs: 53401 9214 10411 3004 3905 9215
2 Indels: 71685 60111

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CRYL1

DNA2.0 Custom Variant and Variant Library Synthesis for CRYL1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CRYL1 for disorders           About GeneDecksing

OMIM gene information: 609877    OMIM disorders: --

5 diseases for CRYL1:    About MalaCards

liver cancer hepatocellular carcinoma tuberculosis carcinoma

mycobacterium tuberculosis

Export disorders for CRYL1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CRYL1 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with CRYL1)

Utopia: connect your pdf to the dynamic
world of online information

Human CRYL1, a novel enzyme-crystallin overexpressed in liver and kidney and downregulated in 58% of liver cancer tissues from 60 Chinese patients, and four new homologs from other mammalians. (PubMed id 12527201)^{1, 2, 3, 9} Chen J....Zhao S. (2003)
Structural and functional characterization of rabbit and human L-gulonate 3-dehydrogenase. (PubMed id 15809331)^{1, 2, 9} Ishikura S....Hara A. (2005)
The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)^{1, 2} Dunham A.... Ross M.T. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)¹ Abdelmohsen K....Gorospe M. (2009)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )² Aoki H.... Hino O. (2000)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 51084	HGNC: 18246	AceView: CRYL1	Ensembl:ENSG00000165475	euGenes: HUgn51084
ECgene: CRYL1	Kegg: 51084	H-InvDB: CRYL1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CRYL1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CRYL1 gene
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Patent Information for CRYL1 gene:
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crystallin, lambda 1

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crystallin, lambda 1

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