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CRYL1 Gene

protein-coding   GIFtS: 53
GCID: GC13M020977

Crystallin, Lambda 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Crystallin, Lambda 11 2     Crystallin, Lamda 12
L-Gulonate 3-Dehydrogenase1 2 3     Epididymis Luminal Protein 302
Lambda-Crystallin Homolog1 2     gul3DH2
crystallin1     lambda-CRY2
Lamda 11     CRY3
GDH2     EC 1.1.1.453
HEL302     Gul3DH3

External Ids:    HGNC: 182461   Entrez Gene: 510842   Ensembl: ENSG000001654757   OMIM: 6098775   UniProtKB: Q9Y2S23   

Export aliases for CRYL1 gene to outside databases

Previous GC identifers: GC13M018957 GC13M014957 GC13M019907 GC13M018775 GC13M019875 GC13M001781


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CRYL1 Gene:
The uronate cycle functions as an alternative glucose metabolic pathway, accounting for about 5% of daily glucose
catabolism. The product of this gene catalyzes the dehydrogenation of L-gulonate into dehydro-L-gulonate in the
uronate cycle. The enzyme requires NAD(H) as a coenzyme, and is inhibited by inorganic phosphate. A similar gene
in the rabbit is thought to serve a structural role in the lens of the eye. (provided by RefSeq, Jul 2008)

GeneCards Summary for CRYL1 Gene:
CRYL1 (crystallin, lambda 1) is a protein-coding gene. Diseases associated with CRYL1 include tuberculosis, and hepatocellular carcinoma. GO annotations related to this gene include protein homodimerization activity and 3-hydroxyacyl-CoA dehydrogenase activity.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000013.11  NT_024524.15  NC_018924.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CRYL1 gene promoter:
         GR   AML1a   Pbx1a   GR-beta   SREBP-1c   SREBP-1b   RORalpha2   AREB6   SREBP-1a   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCRYL1 promoter sequence
   Search Chromatin IP Primers for CRYL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CRYL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q12.11   Ensembl cytogenetic band:  13q12.11   HGNC cytogenetic band: 13q11

CRYL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRYL1 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M020977:  view genomic region     (about GC identifiers)

Start:
20,977,806 bp from pter      End:
21,100,012 bp from pter
Size:
122,207 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CRYL1_HUMAN, Q9Y2S2 (See protein sequence)
Recommended Name: Lambda-crystallin homolog  
Size: 319 amino acids; 35419 Da
Subunit: Homodimer
Sequence caution: Sequence=AAD27782.1; Type=Frameshift; Positions=Several; Sequence=AAD27782.1; Type=Miscellaneous
discrepancy; Note=Unknown reasons;
1 PDB 3D structure from and Proteopedia for CRYL1:
3F3S (3D)    
Secondary accessions: A0PJ43 B3KN92 Q0VDI1 Q7Z4Z9 Q9P0G7
Alternative splicing: 2 isoforms:  Q9Y2S2-1   Q9Y2S2-2   

Explore the universe of human proteins at neXtProt for CRYL1: NX_Q9Y2S2

Explore proteomics data for CRYL1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CRYL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057058.2  
    ENSEMBL proteins: 
     ENSP00000298248   ENSP00000372262  

    CRYL1 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
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    Browse Proteins at Cloud-Clone Corp.

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    LSBio Antibodies in human, mouse, rat for CRYL1

    CRYL1 Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 7):
     IPR008927 6-PGluconate_DH_C-like
     IPR006108 3HC_DH_C
     IPR013328 DH_multihelical
     IPR006176 3-OHacyl-CoA_DH_NAD-bd
     IPR006180 3-OHacyl-CoA_DH_CS

    Graphical View of Domain Structure for InterPro Entry Q9Y2S2

    ProtoNet protein and cluster: Q9Y2S2

    1 Blocks protein domain: IPB006180 3-hydroxyacyl-CoA dehydrogenase

    UniProtKB/Swiss-Prot: CRYL1_HUMAN, Q9Y2S2
    Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family


    CRYL1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CRYL1_HUMAN, Q9Y2S2
    Catalytic activity: L-gulonate + NAD(+) = 3-dehydro-L-gulonate + NADH
    Enzyme regulation: Inhibited by malonate
    Biophysicochemical properties: Kinetic parameters: KM=0.01 mM for NAD; KM=0.0008 mM for NADH;

         Enzyme Number (IUBMB): EC 1.1.1.451

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:00038573-hydroxyacyl-CoA dehydrogenase activity IEA--
    GO:0016491oxidoreductase activity ----
    GO:0042803protein homodimerization activity IPI15809331
    GO:0050104L-gulonate 3-dehydrogenase activity IDA15809331
    GO:0070403NAD+ binding IDA15809331
         
    CRYL1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CRYL1:
     Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

         1 MGI phenotypic allele for Cryl1 (no phenotypes)

    CRYL1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CRYL1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CRYL1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CRYL1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CRYL1

    miRNA
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    miRTarBase miRNAs that target CRYL1:
    hsa-mir-26b-5p (MIRT029226)

    Block miRNA regulation of human, mouse, rat CRYL1 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate CRYL1:
    hsa-miR-548p hsa-miR-3662
    SwitchGear 3'UTR luciferase reporter plasmidCRYL1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CRYL1
    Predesigned siRNA for gene silencing in human, mouse, rat CRYL1

    Gene Editing
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CRYL1 (NM_015974)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRYL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRYL1

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CRYL1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRYL1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CRYL1_HUMAN, Q9Y2S2: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    mitochondrion2
    golgi apparatus1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol ISS--
    GO:0070062extracellular vesicular exosome IDA19056867

    CRYL1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CRYL1 About    
    See pathways by source

    SuperPathContained pathways About
    1Glucuronidation
    Pentose and glucuronate interconversions0.61
    D-glucuronate degradation I0.00
    2Metabolism
    Metabolic pathways0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for CRYL1
        D-glucuronate degradation I


    2 Kegg Pathways  (Kegg details for CRYL1):
        Pentose and glucuronate interconversions
    Metabolic pathways


    CRYL1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including CRYL1: 
              Hepatotoxicity in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CRYL1

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5 Interacting proteins for CRYL1 (Q9Y2S23 ENSP000002982484) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EPS8L2Q9H6S33I2D: score=4 
    GLI2P100703I2D: score=4 
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    ABCC6ENSP000002055574STRING: ENSP00000205557
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006631fatty acid metabolic process IEA--
    GO:0055114oxidation-reduction process ----

    CRYL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CRYL1

    2 HMDB Compounds for CRYL1    About this table
    CompoundSynonyms CAS #PubMed Ids
    (S)-3-Hydroxyhexadecanoyl-CoA(S)-3-hydroxyhexadecanoyl-coenzyme A (see all 14)35106-50-4--
    Acetoacetyl-CoA3-acetoacetyl-CoA (see all 9)1420-36-6--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CRYL1 gene: 
    NM_015974.2  

    Unigene Cluster for CRYL1:

    Crystallin, lambda 1
    Hs.370703  [show with all ESTs]
    Unigene Representative Sequence: BC071810
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000298248(uc001une.3 uc001unf.3) ENST00000382812(uc001ung.3)
    ENST00000480748(uc010tcp.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CRYL1 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate CRYL1:
    hsa-miR-548p hsa-miR-3662
    SwitchGear 3'UTR luciferase reporter plasmidCRYL1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CRYL1
    Predesigned siRNA for gene silencing in human, mouse, rat CRYL1
    Clone
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    OriGene clones in human, mouse for CRYL1 (see all 5)
    OriGene ORF clones in mouse, rat for CRYL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CRYL1 (NM_015974)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRYL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRYL1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CRYL1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CRYL1
      QuantiTect SYBR Green Assays in human, mouse, rat CRYL1
      QuantiFast Probe-based Assays in human, mouse, rat CRYL1

    Additional mRNA sequence: 

    AF077049.1 AF160216.1 AK024041.1 AK301605.1 BC008562.2 BC071810.1 BC119660.1 BC119661.1 

    12 DOTS entries:

    DT.118335  DT.100792105  DT.99992367  DT.95189837  DT.95113696  DT.95189831  DT.100807964  DT.120792710 
    DT.91766486  DT.120792701  DT.95189835  DT.120792746 

    Selected AceView cDNA sequences (see all 205):

    AI273018 BI834560 AW517301 BU733218 BQ006686 BF724794 BI518672 AI474970 
    BI093022 CR591361 CR592394 CA395938 AA299521 CR617362 AK024041 AU143281 
    CR623496 BM707684 BI458419 AI719093 BG398834 BI754315 AI467853 AI285129 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CRYL1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10
    SP1:              -     -                 -                                       
    SP2:              -                       -                                       
    SP3:                                                                              
    SP4:                                                                              


    ECgene alternative splicing isoforms for CRYL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CRYL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAATATGTG
    CRYL1 Expression
    About this image


    CRYL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Kidney (Urinary System)    fully expand to see all 5 entries
             Loop of Henle Cells Loop of Henle
             Proximal Tubule
     
     Epithelial Cells
             Loop of Henle Cells Loop of Henle
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Hindgut
     
     Liver (Hepatobiliary System)
             Periportal Hepatocytes Liver Lobule
     
     Thymus (Hematopoietic System)
             Thymus
    CRYL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CRYL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.370703

    UniProtKB/Swiss-Prot: CRYL1_HUMAN, Q9Y2S2
    Tissue specificity: Widely expressed, with highest levels in liver and kidney

        Pathway & Disease-focused RT2 Profiler PCR Array including CRYL1: 
              Hepatotoxicity in human mouse rat

    Primer
    Products:
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CRYL1
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    QuantiFast Probe-based Assays in human, mouse, rat CRYL1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRYL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CRYL1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cryl11 , 5 crystallin, lambda 11, 5 82.03(n)1
    84.01(a)1
      14 (30.10 cM)5
    686311  NM_030004.31  NP_084280.21 
     572750345 
    chicken
    (Gallus gallus)
    Aves CRYL11 crystallin, lambda 1 68.61(n)
    66.79(a)
      418953  NM_001030830.1  NP_001026001.1 
    lizard
    (Anolis carolinensis)
    Reptilia CRYL16
    crystallin, lambda 1
    62(a)
    1 ↔ 1
    3(187420289-187445987)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.41822 Transcribed sequence with weak similarity to protein more 69.29(n)    AL852853.2 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.130382 Transcribed sequence with weak similarity to protein more 74.21(n)    57087549 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG99141 , 3 CG99141 46(a)
    (best of 2)3
    54.83(n)1
    52.12(a)1
      14B113
    325921  NM_132886.31  NP_573114.21 
    worm
    (Caenorhabditis elegans)
    Secernentea Y71F9B.93   -- 36(a)   I(2759075-2760983)   --


    ENSEMBL Gene Tree for CRYL1 (if available)
    TreeFam Gene Tree for CRYL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CRYL1 (see all 2852)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1929018651,2
    --20977367(+) GGCTGC/GGAAGT 1 -- ds50010--------
    rs170816471,2
    C,F,H--20977507(+) TTGAGT/CGTTGG 1 -- ds500117Minor allele frequency- C:0.05NA NS EA CSA WA 1210
    rs1152035231,2
    F--20977508(+) TGAGTG/ATTGGA 1 -- ds50011Minor allele frequency- A:0.09WA 118
    rs1142495111,2
    F--20977544(+) TTTGGT/GGCCTT 1 -- ds50011Minor allele frequency- G:0.01WA 118
    rs768107191,2
    C,F--20977597(+) GTGATG/ATTTCC 1 -- ds50012Minor allele frequency- A:0.04WA NA 238
    rs1175457981,2
    C,F--20977608(+) CAAACA/GTCATC 1 -- ds50011Minor allele frequency- G:0.01NA 120
    rs1153738711,2
    C,F--20977653(+) TCTGGG/AAAAAG 1 -- ds50011Minor allele frequency- A:0.01WA 118
    rs731608261,2
    C,F--20977667(+) ACATTT/GCTGGA 1 -- ds50013Minor allele frequency- G:0.09CSA WA EA 240
    rs1835530991,2
    --20977754(+) ATGCCA/GGTCAT 1 -- ds50010--------
    rs1154345391,2
    C,F--20977844(+) TAAGCG/ATTAGC 1 -- ut311Minor allele frequency- A:0.02WA 118

    HapMap Linkage Disequilibrium report for CRYL1 (20977806 - 21100012 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CRYL1 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv240e201CNV Deletion23290073
    esv2747066CNV Deletion23290073
    esv2747062CNV Deletion23290073
    esv1659805CNV Insertion17803354
    esv2751132CNV Loss17911159
    dgv1555n71CNV Loss21882294
    nsv818947CNV Loss17921354
    dgv221n27CNV Loss19166990
    dgv1554n71CNV Loss21882294
    esv34984CNV Loss17911159

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609877    OMIM disorders: --

    4 diseases for CRYL1:    
    About MalaCards
    tuberculosis    hepatocellular carcinoma    obesity    malaria


    CRYL1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CRYL1

    Export disorders for CRYL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CRYL1 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with CRYL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human CRYL1, a novel enzyme-crystallin overexpressed in liver and kidney and downregulated in 58% of liver cancer tissues from 60 Chinese patients, and four new homologs from other mammalians. (PubMed id 12527201)1, 2, 3, 9 Chen J....Zhao S. (Gene 2003)
    2. Structural and functional characterization of rabbit and human L- gulonate 3-dehydrogenase. (PubMed id 15809331)1, 2, 9 Ishikura S.... Hara A. (J. Biochem. 2005)
    3. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (Nature 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. (PubMed id 23648065)1 Low S.K....Nakamura Y. (Cancer Sci. 2013)
    6. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    8. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    10. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51084 HGNC: 18246 AceView: CRYL1 Ensembl:ENSG00000165475 euGenes: HUgn51084
    ECgene: CRYL1 Kegg: 51084 H-InvDB: CRYL1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CRYL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CRYL1 gene:
    Search GeneIP for patents involving CRYL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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