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Aliases for CRYGS Gene

Aliases for CRYGS Gene

  • Crystallin, Gamma S 2 3
  • CRYG8 3 4 6
  • Gamma-Crystallin S 3 4
  • Gamma-S-Crystallin 3 4
  • CTRCT20 3 6
  • Crystallin, Gamma 8 3
  • Beta-Crystallin S 3
  • Crystallin 2
  • Gamma 8 2

External Ids for CRYGS Gene

Previous Symbols for CRYGS Gene

  • CRYG8

Summaries for CRYGS Gene

Entrez Gene Summary for CRYGS Gene

  • Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Gamma-crystallins are a homogeneous group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions. They are differentially regulated after early development. This gene encodes a protein initially considered to be a beta-crystallin but the encoded protein is monomeric and has greater sequence similarity to other gamma-crystallins. This gene encodes the most significant gamma-crystallin in adult eye lens tissue. Whether due to aging or mutations in specific genes, gamma-crystallins have been involved in cataract formation. [provided by RefSeq, Jul 2008]

GeneCards Summary for CRYGS Gene

CRYGS (Crystallin, Gamma S) is a Protein Coding gene. Diseases associated with CRYGS include cataract 20, multiple types and autosomal dominant childhood-onset cortical cataract. GO annotations related to this gene include structural constituent of eye lens. An important paralog of this gene is CRYGC.

UniProtKB/Swiss-Prot for CRYGS Gene

  • Crystallins are the dominant structural components of the vertebrate eye lens

Gene Wiki entry for CRYGS Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRYGS Gene

Genomics for CRYGS Gene

Genomic Location for CRYGS Gene

Start:
186,538,441 bp from pter
End:
186,546,702 bp from pter
Size:
8,262 bases
Orientation:
Minus strand

Genomic View for CRYGS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CRYGS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRYGS Gene

Regulatory Elements for CRYGS Gene

Proteins for CRYGS Gene

  • Protein details for CRYGS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22914-CRBS_HUMAN
    Recommended name:
    Beta-crystallin S
    Protein Accession:
    P22914
    Secondary Accessions:
    • B2RAF8

    Protein attributes for CRYGS Gene

    Size:
    178 amino acids
    Molecular mass:
    21007 Da
    Quaternary structure:
    • Monomer

    Three dimensional structures from OCA and Proteopedia for CRYGS Gene

neXtProt entry for CRYGS Gene

Proteomics data for CRYGS Gene at MOPED

Post-translational modifications for CRYGS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CRYGS Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CRYGS Gene

Domains for CRYGS Gene

Protein Domains for CRYGS Gene

UniProtKB/Swiss-Prot:

CRBS_HUMAN
Domain:
  • Has a two-domain beta-structure, folded into four very similar Greek key motifs:
    • P22914
  • Contains 4 beta/gamma crystallin Greek key domains.:
    • P22914
Family:
  • Belongs to the beta/gamma-crystallin family.:
    • P22914
genes like me logo Genes that share domains with CRYGS: view

No data available for Gene Families for CRYGS Gene

Function for CRYGS Gene

Molecular function for CRYGS Gene

GENATLAS Biochemistry: crystallin,gamma S polypeptide
UniProtKB/Swiss-Prot Function: Crystallins are the dominant structural components of the vertebrate eye lens

Gene Ontology (GO) - Molecular Function for CRYGS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005212 structural constituent of eye lens IEA --
genes like me logo Genes that share ontologies with CRYGS: view

Phenotypes for CRYGS Gene

MGI mutant phenotypes for CRYGS:
inferred from 3 alleles
genes like me logo Genes that share phenotypes with CRYGS: view

Animal Models for CRYGS Gene

MGI Knock Outs for CRYGS:

miRNA for CRYGS Gene

miRTarBase miRNAs that target CRYGS

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CRYGS Gene

Localization for CRYGS Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CRYGS Gene COMPARTMENTS Subcellular localization image for CRYGS gene
Compartment Confidence
cytoskeleton 2
cytosol 2
extracellular 2
nucleus 2
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for CRYGS Gene

Pathways for CRYGS Gene

SuperPathways for CRYGS Gene

No Data Available

Interacting Proteins for CRYGS Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000312099%0d%0a9606.ENSP00000300086%0d%0a9606.ENSP00000267415%0d%0a9606.ENSP00000350249%0d%0a
Selected Interacting proteins: ENSP00000312099 for CRYGS Gene via STRING

Gene Ontology (GO) - Biological Process for CRYGS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002009 morphogenesis of an epithelium IEA --
GO:0002088 lens development in camera-type eye IEA --
genes like me logo Genes that share ontologies with CRYGS: view

No data available for Pathways by source for CRYGS Gene

Transcripts for CRYGS Gene

mRNA/cDNA for CRYGS Gene

Unigene Clusters for CRYGS Gene

Crystallin, gamma S:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CRYGS Gene

No ASD Table

Relevant External Links for CRYGS Gene

GeneLoc Exon Structure for
CRYGS
ECgene alternative splicing isoforms for
CRYGS

Expression for CRYGS Gene

mRNA expression in normal human tissues for CRYGS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CRYGS Gene

SOURCE GeneReport for Unigene cluster for CRYGS Gene Hs.376209

genes like me logo Genes that share expressions with CRYGS: view

Orthologs for CRYGS Gene

This gene was present in the common ancestor of chordates.

Orthologs for CRYGS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CRYGS 36
  • 99.63 (n)
  • 98.88 (a)
CRYGS 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CRYGS 36
  • 91.39 (n)
  • 91.57 (a)
CRYGS 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CRYGS 36
  • 91.57 (n)
  • 93.26 (a)
CRYGS 37
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Crygs 36
  • 87.45 (n)
  • 89.89 (a)
Crygs 16
Crygs 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CRYGS 37
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CRYGS 37
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Crygs 36
  • 87.45 (n)
  • 89.89 (a)
chicken
(Gallus gallus)
Aves CRYGS 36
  • 76.22 (n)
  • 72.32 (a)
CRYGS 37
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CRYGS 37
  • 74 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii crygs1 36
  • 69.77 (n)
  • 70.93 (a)
crygs1 37
  • 70 (a)
OneToMany
crygs2 37
  • 66 (a)
OneToMany
crygs3 37
  • 52 (a)
OneToMany
crygs4 37
  • 53 (a)
OneToMany
Dr.15246 36
Species with no ortholog for CRYGS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CRYGS Gene

ENSEMBL:
Gene Tree for CRYGS (if available)
TreeFam:
Gene Tree for CRYGS (if available)

Paralogs for CRYGS Gene

Selected SIMAP similar genes for CRYGS Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CRYGS: view

Variants for CRYGS Gene

Sequence variations from dbSNP and Humsavar for CRYGS Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs12483 -- 186,541,012(-) CTAAG(C/T)CCAAC intron-variant
rs1374808 -- 186,538,344(+) GGAGA(A/G)AATGA downstream-variant-500B
rs1900616 -- 186,541,159(+) GGAAT(A/G)AGAGG intron-variant
rs3774802 -- 186,540,207(+) TAACA(A/G)AATGA intron-variant
rs3774803 -- 186,542,170(+) TGATA(C/T)GGTCA intron-variant

Relevant External Links for CRYGS Gene

HapMap Linkage Disequilibrium report
CRYGS
Human Gene Mutation Database (HGMD)
CRYGS
Locus Specific Mutation Databases (LSDB)
CRYGS

No data available for Structural Variations from Database of Genomic Variants (DGV) for CRYGS Gene

Disorders for CRYGS Gene

(1) OMIM Diseases for CRYGS Gene (123730)

UniProtKB/Swiss-Prot

CRBS_HUMAN
  • Cataract 20, multiple types (CTRCT20) [MIM:116100]: An opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function. CTRCT20 includes progressive polymorphic anterior, posterior, or peripheral cortical. {ECO:0000269 PubMed:16141006}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for CRYGS Gene

(1) Novoseek inferred disease relationships for CRYGS Gene

Disease -log(P) Hits PubMed IDs
cataract 64.3 3
genes like me logo Genes that share disorders with CRYGS: view

Publications for CRYGS Gene

  1. The complete sequence of human lens gamma s-crystallin. (PMID: 7733876) Smith J.B. … Russell P. (Biochem. J. 1995) 3 4 23
  2. Gamma-S crystallin gene (CRYGS) mutation causes dominant progressive cortical cataract in humans. (PMID: 16141006) Sun H. … Shen Y. (J. Med. Genet. 2005) 3 4 23
  3. Primary structure of beta s-crystallin from human lens. (PMID: 1445197) Zarina S. … Zaidi Z.H. (Biochem. J. 1992) 3 4 23
  4. Sequence analysis of betaA3, betaB3, and betaA4 crystallins completes the identification of the major proteins in young human lens. (PMID: 8999933) Lampi K.J. … David L.L. (J. Biol. Chem. 1997) 3 4
  5. The human gene for gammaS-crystallin: alternative transcripts and expressed sequences from the first intron. (PMID: 10837510) Wistow G. … Wyatt M.K. (Mol. Vis. 2000) 3 4

Products for CRYGS Gene

Sources for CRYGS Gene

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