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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CRYGS Gene

protein-coding   GIFtS: 49
GCID: GC03M186256

Crystallin, Gamma S


(Previous symbol: CRYG8)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Crystallin, Gamma S1 2     Beta-Crystallin S2
CRYG81 2 5     Crystallin, Gamma 82
Gamma-Crystallin S2 3     gamma-S-crystallin2
crystallin1     GRYG83
Gamma 81     Gamma-S-crystallin3
CTRCT202     

External Ids:    HGNC: 24171   Entrez Gene: 14272   Ensembl: ENSG000002131397   OMIM: 1237305   UniProtKB: P229143   

Export aliases for CRYGS gene to outside databases

Previous GC identifers: GC03M183027 GC03M187513 GC03M187658 GC03M187577 GC03M187738 GC03M183665


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CRYGS Gene:
Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class
constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the
lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then
retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into
alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta
families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four
homologous motifs, a connecting peptide, and N- and C-terminal extensions. Gamma-crystallins are a homogeneous
group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions.
They are differentially regulated after early development. This gene encodes a protein initially considered to be
a beta-crystallin but the encoded protein is monomeric and has greater sequence similarity to other
gamma-crystallins. This gene encodes the most significant gamma-crystallin in adult eye lens tissue. Whether due
to aging or mutations in specific genes, gamma-crystallins have been involved in cataract formation. (provided by
RefSeq, Jul 2008)

GeneCards Summary for CRYGS Gene: 
CRYGS (crystallin, gamma S) is a protein-coding gene. Diseases associated with CRYGS include autosomal dominant childhood-onset cortical cataract, and endophthalmitis. GO annotations related to this gene include structural constituent of eye lens. An important paralog of this gene is CRYBB3.

UniProtKB/Swiss-Prot: CRBS_HUMAN, P22914
Function: Crystallins are the dominant structural components of the vertebrate eye lens

Gene Wiki entry for CRYGS Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_005612.16  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CRYGS gene promoter:
         AhR   RP58   p53   Pax-5   AML1a   Lmo2   Arnt   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCRYGS promoter sequence
   Search SABiosciences Chromatin IP Primers for CRYGS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CRYGS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q27.3   Ensembl cytogenetic band:  3q27.3   HGNC cytogenetic band: 3q27.3

CRYGS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRYGS gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M186256:  view genomic region     (about GC identifiers)

Start:
186,256,230 bp from pter      End:
186,264,491 bp from pter
Size:
8,262 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CRBS_HUMAN, P22914 (See protein sequence)
Recommended Name: Beta-crystallin S  
Size: 178 amino acids; 21007 Da
Subunit: Monomer
Mass spectrometry: Mass=20918; Mass_error=0.3; Method=Electrospray; Range=2-178; Source=PubMed:8999933;
1 PDB 3D structure from and Proteopedia for CRYGS:
1HA4 (3D)    
Secondary accessions: B2RAF8

Explore the universe of human proteins at neXtProt for CRYGS: NX_P22914

Explore proteomics data for CRYGS at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P22914

  • CRYGS Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CRYGS Protein Expression
    REFSEQ proteins: NP_060011.1  
    ENSEMBL proteins: 
     ENSP00000376287   ENSP00000312099  

    Human Recombinant Protein Products for CRYGS: 
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    OriGene Purified Protein for CRYGS
    OriGene Protein Over-expression Lysate for CRYGS
    OriGene MassSpec for CRYGS 
    OriGene Custom Protein Services for CRYGS
    GenScript Custom Purified and Recombinant Proteins Services for CRYGS
    Novus Biologicals CRYGS Proteins
    Novus Biologicals CRYGS Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for CRYGS
    Browse Proteins at Cloud-Clone Corp. 


    CRYGS Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for CRYGS 

    Assay Products for CRYGS: 
    Browse Kits and Assays available from EMD Millipore
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    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR001064 Beta/gamma_crystallin
     IPR011024 G_crystallin-rel

    Graphical View of Domain Structure for InterPro Entry P22914

    ProtoNet protein and cluster: P22914

    2 Blocks protein domains:
    IPB001064 Beta and gamma crystallin
    IPB011024 Gamma-crystallin related


    UniProtKB/Swiss-Prot: CRBS_HUMAN, P22914
    Domain: Has a two-domain beta-structure, folded into four very similar Greek key motifs
    Similarity: Belongs to the beta/gamma-crystallin family
    Similarity: Contains 4 beta/gamma crystallin 'Greek key' domains


    CRYGS for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CRBS_HUMAN, P22914
    Function: Crystallins are the dominant structural components of the vertebrate eye lens

         Genatlas biochemistry entry for CRYGS:
    crystallin,gamma S polypeptide

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005212structural constituent of eye lens IEA--
         
    CRYGS for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Crygs):
     vision/eye 

    CRYGS for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CRYGS 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CRYGS

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CRYGS 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CRYGS 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CRYGS
    1 QIAGEN miScript miRNA Assays for microRNA that regulate CRYGS:
    hsa-miR-3194-5p
    SwitchGear 3'UTR luciferase reporter plasmidCRYGS 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CRYGS (see all 6)
    OriGene ORF clones in mouse, rat for CRYGS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CRYGS (NM_017541)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRYGS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRYGS
    Sirion Biotech Customized lentivirus for stable overexpression of CRYGS 
                         Customized lentivirus expression plasmids for stable overexpression of CRYGS 

    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRYGS


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CRYGS

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for CRYGS (ENSP000003120994) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    POT1ENSP000003502494STRING: ENSP00000350249
    TERF2IPENSP000003000864STRING: ENSP00000300086
    TINF2ENSP000002674154STRING: ENSP00000267415
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002009morphogenesis of an epithelium IEA--
    GO:0002088lens development in camera-type eye IEA--

    CRYGS for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CRYGS (CRBS)

    Search CenterWatch for drugs/clinical trials and news about CRYGS / CRBS

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CRYGS gene: 
    NM_017541.2  

    Unigene Cluster for CRYGS:

    Crystallin, gamma S
    Hs.376209  [show with all ESTs]
    Unigene Representative Sequence: BX648612
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000392499(uc003fqe.3) ENST00000460288 ENST00000307944
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CRYGS
    1 QIAGEN miScript miRNA Assays for microRNA that regulate CRYGS:
    hsa-miR-3194-5p
    SwitchGear 3'UTR luciferase reporter plasmidCRYGS 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CRYGS
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CRYGS
    Clone
    Products:
         
    OriGene clones in human, mouse for CRYGS (see all 6)
    OriGene ORF clones in mouse, rat for CRYGS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CRYGS (NM_017541)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRYGS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRYGS
    Sirion Biotech Customized lentivirus for stable overexpression of CRYGS 
                         Customized lentivirus expression plasmids for stable overexpression of CRYGS 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CRYGS
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CRYGS
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CRYGS
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRYGS

    Additional mRNA sequence: 

    AF161703.1 AK095814.1 AK314172.1 AL133079.1 BC069478.1 BC070241.1 BX648612.1 L36869.1 

    6 DOTS entries:

    DT.100749390  DT.97854735  DT.100002505  DT.441424  DT.97800139  DT.97854734 

    24/211 AceView cDNA sequences (see all 211):

    BF727274 BM696925 AI333288 BM696295 BM696867 BM667778 AF161703 BM697737 
    BF726925 BF726103 BM727363 BM697355 BU735261 BM706329 BF726832 AI078455 
    BM706267 BM704957 BF726458 BM696940 BM705807 BM706198 BU734762 BU735510 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CRYGS expression in normal human tissues (normalized intensities)      CRYGS embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATCCCAAAA
    CRYGS Expression
    About this image


    CRYGS expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 5 entries
             Retina
             Human Lens Epithelial Cells (HLEpiC)   
             cornea   
     
     Bone (Muscoskeletal System)
             HyStem+TGFbeta3+GDF5-induced 4D20.8 cells
     
     Cartilage (Muscoskeletal System)
             HyStem+TGFbeta3+GDF5-induced 4D20.8 cells
     
     Epithelium (Uncategorized)
             Human Lens Epithelial Cells (HLEpiC)   
     
     Thyroid (Endocrine System)

    See CRYGS Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CRYGS

    SOURCE GeneReport for Unigene cluster: Hs.376209
        SABiosciences Custom PCR Arrays for CRYGS
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRYGS
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRYGS

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CRYGS gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Crygs1 , 5 crystallin, gamma S1, 5 87.45(n)1
    89.89(a)1
      16 (13.66 cM)5
    129701  NM_009967.21  NP_034097.11 
     228052035 
    chicken
    (Gallus gallus)
    Aves CRYGS1 crystallin, gamma S 76.22(n)
    72.32(a)
      429134  NM_001170527.1  NP_001163998.1 
    lizard
    (Anolis carolinensis)
    Reptilia CRYGS6
    crystallin, gamma S
    74(a)
    1 ↔ 1
    3(33565289-33570151)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.152462 Transcribed sequence with weak similarity to protein spP22914 (H.sapiens) CRBS_HUMAN Beta crystallin S (Gamma crystallin S) less 73.31(n)    CK029913.1 


    ENSEMBL Gene Tree for CRYGS (if available)
    TreeFam Gene Tree for CRYGS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CRYGS gene
    CRYBB32  CRYGB2  CRYBA42  CRYBA12  CRYBB22  CRYGD2  CRYGA2  CRYBB12  
    CRYGC2  CRYBA22  CRYGN2  
    14 SIMAP similar genes for CRYGS using alignment to 1 protein entry:     CRBS_HUMAN:
    DKFZp434A0627    CRYGB    CRYGC    CRYGD    CRYGA    CRYGN
    CRYBB3    CRYBB2    CRYBB1    CRYBA2    CRYBA4    AIM1L
    CRYBA1    DKFZp434L1713

    CRYGS for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/176 SNPs in CRYGS are shown (see all 176)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1048937361,2
    Cpathogenic1186126403(-) TCAAGG/TCCGTC 2 G V mis10--------
    rs615290861,2
    C,F--186124890(+) ACTGGC/TTGTTC 1 -- ds50012Minor allele frequency- T:0.50WA 4
    rs1427760961,2
    --186124892(+) GGCTG-/GTTTT 
            
    TTCTT
    1 -- ds50010--------
    rs1491181961,2
    --186124940(+) ACCCCA/GTCTTT 1 -- ds50010--------
    rs46867851,2
    H--186125001(+) CTCCAG/TCCAAT 1 -- ds50013Minor allele frequency- T:0.00EA NS 300
    rs13748081,2
    C,F,A,H--186125181(+) GGAGAA/GAATGA 1 -- ds500118Minor allele frequency- G:0.42EA NS NA 2002
    rs1422021761,2
    --186125279(+) TCAGTA/GTGACT 1 -- ds50010--------
    rs46867861,2
    H--186125397(+) GCTGGT/CCCCTA 1 -- ut313Minor allele frequency- C:0.00EA NS 300
    rs1512509521,2
    --186125476(+) ATTTGA/GACCAC 1 -- ut310--------
    rs2017178801,2
    C--186125546(+) CAATGC/TGGCGG 2 H R mis11Minor allele frequency- T:0.00EU 1323

    HapMap Linkage Disequilibrium report for CRYGS (186256230 - 186264491 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CRYGS: --

    Human Gene Mutation Database (HGMD): CRYGS

    Locus Specific Mutation Databases (LSDB): CRYGS
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CRYGS
    DNA2.0 Custom Variant and Variant Library Synthesis for CRYGS

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 123730    OMIM disorders: --

    8 diseases for CRYGS:    About MalaCards
    autosomal dominant childhood-onset cortical cataract    endophthalmitis    diabetic cataract    posterior polar cataract
    senile cataract    cataract    microphthalmia    blindness

    1 disease from the University of Copenhagen DISEASES database for CRYGS:
    Senile cataract

    CRYGS for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for CRYGS gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cataract 64.3 3 16141006 (1), 20450675 (1), 19224648 (1)


    Export disorders for CRYGS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CRYGS gene, integrated from 9 sources (see all 52):
    (articles sorted by number of sources associating them with CRYGS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Primary structure of beta s-crystallin from human lens. (PubMed id 1445197)1, 2, 9 Zarina S.... Zaidi Z.H. (1992)
    2. The complete sequence of human lens gamma s-crystallin. (PubMed id 7733876)1, 2, 9 Smith J.B.... Russell P. (1995)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The X-ray crystal structure of human gamma S-crystallin C-terminal domain. (PubMed id 11706012)1, 2 Purkiss A.G.... Slingsby C. (2002)
    5. The human gene for gammaS-crystallin: alternative transcripts and expressed sequences from the first intron. (PubMed id 10837510)1, 2 Wistow G.... Wyatt M.K. (2000)
    6. Sequence analysis of betaA3, betaB3, and betaA4 crystallins completes the identification of the major proteins in young human lens. (PubMed id 8999933)1, 2 Lampi K.J....David L.L. (1997)
    7. Gamma-S crystallin gene (CRYGS) mutation causes dominant progressive cortical cataract in humans. (PubMed id 16141006)1, 9 Sun H....Shen Y. (2005)
    8. Mechanism of the very efficient quenching of tryptoph an fluorescence in human gamma D- and gamma S-crystallins: the gamma-crystallin fold may have evolved to protect tryptophan residues from ultraviolet photodam age. (PubMed id 19358562)1, 9 Chen J....King J. (2009)
    9. Three-dimensional model and quaternary structure of the human eye lens protein gamma S-crystallin based on beta- and gamma-crystallin X-ray coordinates and ultracentrifugation. (PubMed id 7849599)1, 9 Zarina S....Srinivasan N. (1994)
    10. Structural analysis of the mutant protein D26G of huma n gS-crystallin, associated with Coppock cataract. (PubMed id 23761725)1 Karri S....Balasubramanian D. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1427 HGNC: 2417 AceView: CRYGSandFLJ10560 Ensembl:ENSG00000213139 euGenes: HUgn1427
    ECgene: CRYGS H-InvDB: CRYGS

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CRYGS Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CRYGS gene:
    Search GeneIP for patents involving CRYGS

    GeneCards and IP:
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