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CRYGS Gene

protein-coding   GIFtS: 50
GCID: GC03M186256

Crystallin, Gamma S


(Previous symbol: CRYG8)
  See CRYGS-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Crystallin, Gamma S1 2     Gamma 81
CRYG81 2 3 5     Beta-Crystallin S2
Gamma-Crystallin S2 3     Crystallin, Gamma 82
CTRCT202 5     gamma-S-crystallin2
crystallin1     Gamma-S-crystallin3

External Ids:    HGNC: 24171   Entrez Gene: 14272   Ensembl: ENSG000002131397   OMIM: 1237305   UniProtKB: P229143   

Export aliases for CRYGS gene to outside databases

Previous GC identifers: GC03M183027 GC03M187513 GC03M187658 GC03M187577 GC03M187738 GC03M183665


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CRYGS Gene:
Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class
constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the
lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then
retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into
alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta
families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four
homologous motifs, a connecting peptide, and N- and C-terminal extensions. Gamma-crystallins are a homogeneous
group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions.
They are differentially regulated after early development. This gene encodes a protein initially considered to be
a beta-crystallin but the encoded protein is monomeric and has greater sequence similarity to other
gamma-crystallins. This gene encodes the most significant gamma-crystallin in adult eye lens tissue. Whether due
to aging or mutations in specific genes, gamma-crystallins have been involved in cataract formation. (provided by
RefSeq, Jul 2008)

GeneCards Summary for CRYGS Gene:
CRYGS (crystallin, gamma S) is a protein-coding gene. Diseases associated with CRYGS include autosomal dominant childhood-onset cortical cataract, and cataract 20, multiple types. GO annotations related to this gene include structural constituent of eye lens. An important paralog of this gene is CRYBB3.

UniProtKB/Swiss-Prot: CRBS_HUMAN, P22914
Function: Crystallins are the dominant structural components of the vertebrate eye lens

Gene Wiki entry for CRYGS Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the CRYGS gene promoter:
         AhR   RP58   p53   Pax-5   AML1a   Lmo2   Arnt   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCRYGS promoter sequence
   Search Chromatin IP Primers for CRYGS

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CRYGS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q27.3   Ensembl cytogenetic band:  3q27.3   HGNC cytogenetic band: 3q27.3

CRYGS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRYGS gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M186256:  view genomic region     (about GC identifiers)

Start:
186,256,230 bp from pter      End:
186,264,491 bp from pter
Size:
8,262 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CRBS_HUMAN, P22914 (See protein sequence)
Recommended Name: Beta-crystallin S  
Size: 178 amino acids; 21007 Da
Subunit: Monomer
Mass spectrometry: Mass=20918; Mass_error=0.3; Method=Electrospray; Range=2-178; Source=PubMed:8999933;
3 PDB 3D structures from and Proteopedia for CRYGS:
1HA4 (3D)        2M3T (3D)        2M3U (3D)    
Secondary accessions: B2RAF8

Explore the universe of human proteins at neXtProt for CRYGS: NX_P22914

Explore proteomics data for CRYGS at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CRYGS Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060011.1  
    ENSEMBL proteins: 
     ENSP00000376287   ENSP00000312099  

    CRYGS Human Recombinant Protein Products:

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    Novus Biologicals CRYGS Proteins
    Novus Biologicals CRYGS Lysates
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    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for CRYGS
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for CRYGS 

     
    antibodies-online proteins for CRYGS (12 products) 

     
    antibodies-online peptides for CRYGS

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    antibodies-online antibodies for CRYGS (41 products) 

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    antibodies-online kits for CRYGS (13 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR001064 Beta/gamma_crystallin
     IPR011024 G_crystallin-rel

    Graphical View of Domain Structure for InterPro Entry P22914

    ProtoNet protein and cluster: P22914

    2 Blocks protein domains:
    IPB001064 Beta and gamma crystallin
    IPB011024 Gamma-crystallin related


    UniProtKB/Swiss-Prot: CRBS_HUMAN, P22914
    Domain: Has a two-domain beta-structure, folded into four very similar Greek key motifs
    Similarity: Belongs to the beta/gamma-crystallin family
    Similarity: Contains 4 beta/gamma crystallin 'Greek key' domains


    Find genes that share domains with CRYGS           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CRBS_HUMAN, P22914
    Function: Crystallins are the dominant structural components of the vertebrate eye lens

         Genatlas biochemistry entry for CRYGS:
    crystallin,gamma S polypeptide

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005212structural constituent of eye lens IEA--
         
    Find genes that share ontologies with CRYGS           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 3 alleles(MGI details for Crygs):
     vision/eye 

    Find genes that share phenotypes with CRYGS           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Crygstm1Gwis for CRYGS

       genOway: Develop your customized and physiologically relevant rodent model for CRYGS

    miRNA
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    miRTarBase miRNAs that target CRYGS:
    hsa-mir-1 (MIRT023836), hsa-mir-335-5p (MIRT018053)

    Block miRNA regulation of human, mouse, rat CRYGS using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate CRYGS:
    hsa-miR-3194-5p
    SwitchGear 3'UTR luciferase reporter plasmidCRYGS 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton2
    cytosol2
    extracellular2
    nucleus2
    plasma membrane1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CRYGS
    Interactions:

        Search GeneGlobe Interaction Network for CRYGS

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for CRYGS (ENSP000003120994) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    POT1ENSP000003502494STRING: ENSP00000350249
    TERF2IPENSP000003000864STRING: ENSP00000300086
    TINF2ENSP000002674154STRING: ENSP00000267415
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002009morphogenesis of an epithelium IEA--
    GO:0002088lens development in camera-type eye IEA--

    Find genes that share ontologies with CRYGS           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CRYGS (CRBS)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CRYGS gene: 
    NM_017541.2  

    Unigene Cluster for CRYGS:

    Crystallin, gamma S
    Hs.376209  [show with all ESTs]
    Unigene Representative Sequence: BX648612
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000392499(uc003fqe.3) ENST00000460288 ENST00000307944
    miRNA
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    Block miRNA regulation of human, mouse, rat CRYGS using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate CRYGS:
    hsa-miR-3194-5p
    SwitchGear 3'UTR luciferase reporter plasmidCRYGS 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CRYGS
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRYGS
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CRYGS
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CRYGS
      QuantiTect SYBR Green Assays in human, mouse, rat CRYGS
      QuantiFast Probe-based Assays in human, mouse, rat CRYGS

    Additional mRNA sequence: 

    AF161703.1 AK095814.1 AK314172.1 AL133079.1 BC069478.1 BC070241.1 BX648612.1 L36869.1 

    6 DOTS entries:

    DT.100749390  DT.97854735  DT.100002505  DT.441424  DT.97800139  DT.97854734 

    Selected AceView cDNA sequences (see all 211):

    BF727278 BF727370 BU735289 BM706329 BM705807 BF726485 BU735191 BM705804 
    BM706398 BP353224 BM706007 BM704998 BF726458 BM697737 BP353978 BM706198 
    BF726103 BM727363 BF727017 BM697355 BF727032 BM667788 BF727085 BM697123 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CRYGS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATCCCAAAA
    CRYGS Expression
    About this image


    CRYGS expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Eye (Sensory Organs)
             Retina
     
     Bone (Muscoskeletal System)
             HyStem+TGFbeta3+GDF5-induced 4D20.8 cells
     
     Cartilage (Muscoskeletal System)
             HyStem+TGFbeta3+GDF5-induced 4D20.8 cells
     
     Thyroid (Endocrine System)
    CRYGS Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CRYGS Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.376209
        Custom PCR Arrays for CRYGS
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRYGS

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CRYGS gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Crygs1 , 5 crystallin, gamma S1, 5 87.45(n)1
    89.89(a)1
      16 (13.66 cM)5
    129701  NM_009967.21  NP_034097.11 
     228052035 
    chicken
    (Gallus gallus)
    Aves CRYGS1 crystallin, gamma S 76.22(n)
    72.32(a)
      429134  NM_001170527.1  NP_001163998.1 
    lizard
    (Anolis carolinensis)
    Reptilia CRYGS6
    crystallin, gamma S
    74(a)
    1 ↔ 1
    3(33565289-33570151)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.152462 Transcribed sequence with weak similarity to protein more 73.31(n)    CK029913.1 


    ENSEMBL Gene Tree for CRYGS (if available)
    TreeFam Gene Tree for CRYGS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CRYGS gene
    CRYBB32  CRYGB2  CRYBA42  CRYBA12  CRYBB22  CRYGD2  CRYGA2  CRYBB12  
    CRYGC2  CRYBA22  CRYGN2  
    14 SIMAP similar genes for CRYGS using alignment to 1 protein entry:     CRBS_HUMAN:
    DKFZp434A0627    CRYGB    CRYGC    CRYGD    CRYGA    CRYGN
    CRYBB3    CRYBB2    CRYBB1    CRYBA2    CRYBA4    AIM1L
    CRYBA1    DKFZp434L1713

    Find genes that share paralogs with CRYGS           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CRYGS (see all 177)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0697974
    Cataract 20, multiple types (CTRCT20)4--see VAR_0697972 G V mis40--------
    rs1048937361,2
    Cpathogenic1186126403(-) TCAAGG/TCCGTC 2 G V mis10--------
    rs615290861,2
    C,F--186124890(+) ACTGGC/TTGTTC 1 -- ds50012Minor allele frequency- T:0.50WA 4
    rs1427760961,2
    --186124892(+) GGCTG-/GTTTT 
            
    TTCTT
    1 -- ds50010--------
    rs1491181961,2
    --186124940(+) ACCCCA/GTCTTT 1 -- ds50010--------
    rs46867851,2
    H--186125001(+) CTCCAG/TCCAAT 1 -- ds50013Minor allele frequency- T:0.00EA NS 300
    rs13748081,2
    C,F,A,H--186125181(+) GGAGAA/GAATGA 1 -- ds500118Minor allele frequency- G:0.42EA NS NA 2002
    rs1422021761,2
    --186125279(+) TCAGTA/GTGACT 1 -- ds50010--------
    rs46867861,2
    H--186125397(+) GCTGGT/CCCCTA 1 -- ut313Minor allele frequency- C:0.00EA NS 300
    rs1512509521,2
    --186125476(+) ATTTGA/GACCAC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CRYGS (186256230 - 186264491 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CRYGS: --
    Human Gene Mutation Database (HGMD): CRYGS
    Locus Specific Mutation Databases (LSDB): CRYGS

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CRYGS
    DNA2.0 Custom Variant and Variant Library Synthesis for CRYGS

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 123730   
    OMIM disorders: 116100  
    UniProtKB/Swiss-Prot: CRBS_HUMAN, P22914
  • Cataract 20, multiple types (CTRCT20) [MIM:116100]: An opacification of the crystalline lens of the eye
    that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a
    portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an
    opacity, the greater the impact on visual function. CTRCT20 includes progressive polymorphic anterior, posterior,
    or peripheral cortical. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 4 diseases for CRYGS:    
    About MalaCards
    autosomal dominant childhood-onset cortical cataract    cataract 20, multiple types    birt-hogg-dube syndrome    cataract

    1 disease from the University of Copenhagen DISEASES database for CRYGS:
    Senile cataract

    Find genes that share disorders with CRYGS           About GenesLikeMe

    1 Novoseek inferred disease relationship for CRYGS gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cataract 64.3 3 16141006 (1), 20450675 (1), 19224648 (1)


    Export disorders for CRYGS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CRYGS gene, integrated from 10 sources (see all 53):
    (articles sorted by number of sources associating them with CRYGS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Gamma-S crystallin gene (CRYGS) mutation causes dominant progressive cortical cataract in humans. (PubMed id 16141006)1, 2, 9 Sun H....Shen Y. (J. Med. Genet. 2005)
    2. Primary structure of beta s-crystallin from human lens. (PubMed id 1445197)1, 2, 9 Zarina S.... Zaidi Z.H. (Biochem. J. 1992)
    3. The complete sequence of human lens gamma s-crystallin. (PubMed id 7733876)1, 2, 9 Smith J.B.... Russell P. (Biochem. J. 1995)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The X-ray crystal structure of human gamma S-crystallin C-terminal domain. (PubMed id 11706012)1, 2 Purkiss A.G.... Slingsby C. (J. Biol. Chem. 2002)
    6. The human gene for gammaS-crystallin: alternative transcripts and expressed sequences from the first intron. (PubMed id 10837510)1, 2 Wistow G.... Wyatt M.K. (Mol. Vis. 2000)
    7. Sequence analysis of betaA3, betaB3, and betaA4 crystallins completes the identification of the major proteins in young human lens. (PubMed id 8999933)1, 2 Lampi K.J....David L.L. (J. Biol. Chem. 1997)
    8. Mechanism of the very efficient quenching of tryptophan fluorescence in human gamma D- and gamma S-crystallins: the gamma-crystallin fold may have evolved to protect tryptophan residues from ultraviolet photodamage. (PubMed id 19358562)1, 9 Chen J....King J. (Biochemistry 2009)
    9. Three-dimensional model and quaternary structure of the human eye lens protein gamma S-crystallin based on beta- and gamma-crystallin X-ray coordinates and ultracentrifugation. (PubMed id 7849599)1, 9 Zarina S....Srinivasan N. (Protein Sci. 1994)
    10. Structural analysis of the mutant protein D26G of human I^S-crystallin, associated with Coppock cataract. (PubMed id 23761725)1 Karri S....Balasubramanian D. (Mol. Vis. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1427 HGNC: 2417 AceView: CRYGSandFLJ10560 Ensembl:ENSG00000213139 euGenes: HUgn1427
    ECgene: CRYGS H-InvDB: CRYGS

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CRYGS Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    Patent Information for CRYGS gene:
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