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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CRYGN Gene

protein-coding GIFtS: 44
GCID: GC07M151125

crystallin, gamma N

Explore 1 disease affiliated with
CRYGN via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Crystallin, Gamma N¹ ²
Gamma-N-Crystallin¹
Gamma-Crystallin N²
GammaN-Crystallin¹
Gamma-N-Crystallin¹

External Ids:	HGNC: 20458¹	Entrez Gene: 155051²	Ensembl: ENSG00000127377⁷	OMIM: 609603⁵	UniProtKB: Q8WXF5³

Export aliases for CRYGN gene to outside databases

Previous GC identifers: GC07M149373 GC07M150440 GC07M150517 GC07M150564 GC07M150757 GC07M144938

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CRYGN:

The beta and gamma crystallins are evolutionarily related families of proteins that are localized to the refractive

structure of the eye lens. The protein encoded by this gene is unique in that it has both beta and gamma crystallin

protein motifs. (provided by RefSeq, Jul 2008)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007914.15 NT_079596.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CRYGN gene promoter:
STAT1 AML1a AP-4 C/EBPalpha FOXL1 CHOP-10 PPAR-gamma1 PPAR-gamma2 Zic3 TGIF
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CRYGN promoter sequence

Search SABiosciences Chromatin IP Primers for CRYGN

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CRYGN

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q36.1 Ensembl cytogenetic band: 7q36.1 HGNC cytogenetic band: 7q36.1

CRYGN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRYGN gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07M151125: view genomic region (about GC identifiers)

Start:	151,125,921 bp from pter	End:	151,137,899 bp from pter
Size:	11,979 bases	Orientation:	minus strand

1 alternative location:

Chr7-,CRA_TCAG 150,456,639-150,466,682

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
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About This Section

UniProtKB/Swiss-Prot: CRGN_HUMAN, Q8WXF5 (See protein sequence)

Recommended Name: Gamma-crystallin N

Size: 182 amino acids; 20624 Da

Subunit: Monomer (By similarity)

Caution: In contrast to the orthologous protein found in other species, the C-terminal part differs and lacks the

fourth beta/gamma crystallin 'Greek key' domain. Moreover, its non-specific tissue specificity suggests that it may

have lost its function (PubMed:15853812)

Secondary accessions: Q496G6

Alternative splicing: 2 isoforms: Q8WXF5-1 Q8WXF5-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CRYGN: NX_Q8WXF5

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8WXF5

CRYGN Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_653328.1

ENSEMBL proteins:

ENSP00000338613 ENSP00000420157

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CRYGN for domains About GeneDecksing

2 InterPro domains/families:

IPR001064 Beta/gamma_crystallin

IPR011024 G_crystallin-rel

Graphical View of Domain Structure for InterPro Entry Q8WXF5

ProtoNet protein and cluster: Q8WXF5

2 Blocks protein families:

IPB001064 Beta and gamma crystallin

IPB011024 Gamma-crystallin related

UniProtKB/Swiss-Prot: CRGN_HUMAN, Q8WXF5

Similarity: Belongs to the beta/gamma-crystallin family

Similarity: Contains 3 beta/gamma crystallin 'Greek key' domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CRYGN

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for CRYGN gene:

NM_144727.1

Unigene Cluster for CRYGN:

Crystallin, gamma N

Hs.647104 [show with all ESTs]

Unigene Representative Sequence: BM548090

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000476631(uc003wkg.3) ENST00000462809 ENST00000337323(uc003wke.3)

ENST00000491928(uc003wkf.3) ENST00000478106(uc010lqd.1)

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Additional cDNA sequence:

AF445455.1 BC100878.2 BC100879.3 BC100880.2 BC100881.2 EF491784.1

2 DOTS entries:

DT.97793177 DT.97807740

7 AceView cDNA sequences:

BU683519 AF445455 NM_144727 BM548090 CB993791 BC043605 BI003328

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for CRYGN About this scheme

ExUns:	1	^	2a	·	2b	^	3	^	4	^	5a	·	5b	·	5c
SP1:					-		-
SP2:							-		-
SP3:

ECgene alternative splicing isoforms for CRYGN

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CRYGN expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCCTCAAAAA

About this image

CRYGN expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Lens

Eye

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CRYGN Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CRYGN

SOURCE GeneReport for Unigene cluster: Hs.647104

UniProtKB/Swiss-Prot: CRGN_HUMAN, Q8WXF5

Tissue specificity: Not specifically expressed in eye

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CRYGN gene from 3/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CRYGN¹	crystallin, gamma N	70.74(n) 61.87(a)		428406 NM_001166674.2 NP_001160146.2
lizard (Anolis carolinensis)	Reptilia	CRYGN⁶	--	53(a)	1 ↔ 1	6(3937681-3950417)
zebrafish (Danio rerio)	Actinopterygii	Dr.29203²	Transcribed sequence with weak similarity to protein more	76.47(n)		CB359117.1

ENSEMBL Gene Tree for CRYGN (if available)
TreeFam Gene Tree for CRYGN (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CRYGN gene

CRYBB3² CRYGB² CRYBA4² CRYBA1² CRYBB2² CRYGD² CRYGA² CRYBB1²

CRYGC² CRYBA2² CRYGS²

9 SIMAP similar genes for CRYGN using alignment to 1 protein entry: CRGN_HUMAN:

CRYGS CRYBB3 CRYBA2 CRYGA CRYGB CRYGC

CRYBA1 CRYGD CRYBA4

CRYGN for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs62479789^1,2	C,F,	--	151126556(+)	`TTTGCG/ACCAAA`	1	--	ds500¹		3		NA	124
rs115334446^1,2	F,	--	151126625(+)	`AGGAAC/TGAAAA`	1	--	ds500¹		1		WA	118
rs58895287^1,2	C,	--	151126702(+)	`AACCTG/CTCTGT`	1	--	ds500¹		1		WA	2
rs111968470^1,2		--	151126790(+)	`AGATTC/TCAGCT`	1	--	ds500¹		1		CSA	2
rs7808369^1,2	C,F,A,H,	--	151126822(+)	`TCAGTG/ACTCCA`	1	--	ds500¹		18		NS EA NA CSA WA	2340
rs191509187^1,2		--	151126838(+)	`ATTCAA/TCAACA`	1	--	ds500¹		0	--	--	--	--
rs117091308^1,2	F,	--	151126840(+)	`TCATCA/GACATC`	1	--	ds500¹		1		EA	120
rs11768968^1,2	C,F,A,H,	--	151126851(+)	`ATCACC/TATCAT`	1	--	ds500¹		19		NS EA NA WA	2340
rs183989824^1,2		--	151126875(+)	`AGGTGA/CGAGAT`	1	--	ds500¹		0	--	--	--	--
rs113313448^1,2	C,	--	151126943(+)	`TTGGAC/TGGCTG`	1	--	ds500¹		2		CSA WA	120

HapMap Linkage Disequilibrium report for CRYGN (151125921 - 151137899 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CRYGN: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CRYGN for disorders           About GeneDecksing

OMIM gene information: 609603    OMIM disorders: --

1 disease for CRYGN:    About MalaCards

cataract

Export disorders for CRYGN gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CRYGN gene integrated from 9 sources:
(articles sorted by number of sources associating them with CRYGN)

Utopia: connect your pdf to the dynamic
world of online information

Gamma-N-crystallin and the evolution of the betagamma-crystallin superfamily in vertebrates. (PubMed id 15853812)^{1, 2} Wistow G.... Vihtelic T. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)¹ Scherer S.W.... Tsui L.-C. (2003)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Genetics of crystallins: cataract and beyond. (PubMed id 19007775)⁹ Graw J. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 155051	HGNC: 20458	AceView: CRYGN	Ensembl:ENSG00000127377	euGenes: HUgn155051
ECgene: CRYGN	H-InvDB: CRYGN

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CRYGN	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CRYGN gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CRYGN gene:
Search GeneIP for patents involving CRYGN

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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	See all of Abcam's Antibodies, Kits and Proteins for CRYGN
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Recombinant Protein for CRYGN

Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn

Search LifeMap BioReagents cell lines for CRYGN

	Gene Synthesis
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRYGN

	Browse SwitchGear 3'UTR luciferase reporter plasmids for CRYGN
	SwitchGear Promoter luciferase reporter plasmids for CRYGN

Search ThermoFisher Antibodies for CRYGN

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRYGN

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes CRYGN gene at Home site.

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CRYGN Gene

crystallin, gamma N

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Export list of displayed genes

CRYGN Gene

crystallin, gamma N

Aliasesfor CRYGN gene

Summariesfor CRYGN gene

Genomic Viewsfor CRYGN gene

Proteinsfor CRYGN gene

Protein Domains /Familiesfor CRYGN gene

Functionfor CRYGN gene

Pathways & Interactionsfor CRYGN gene

Drugs & Compoundsfor CRYGN gene

Transcriptsfor CRYGN gene

Expression for CRYGN gene

Orthologsfor CRYGN gene

Paralogsfor CRYGN gene

Genomic Variantsfor CRYGN gene

Disorders / Diseasesfor CRYGN gene

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External Searches for CRYGN gene

Genome Databases showing CRYGN gene

Other Databases showing CRYGN gene

Specialized Databases showing CRYGN gene

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Aliases
for CRYGN gene

Summaries
for CRYGN gene

Genomic Views
for CRYGN gene

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for CRYGN gene

Protein Domains /
Families
for CRYGN gene

Function
for CRYGN gene

Pathways & Interactions
for CRYGN gene

Drugs & Compounds
for CRYGN gene

Transcripts
for CRYGN gene

Expression
for CRYGN gene

Orthologs
for CRYGN gene

Paralogs
for CRYGN gene

Genomic Variants
for CRYGN gene

Disorders / Diseases
for CRYGN gene

Publications
for CRYGN gene

Intellectual Property
for CRYGN gene

Products
for CRYGN gene