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Aliases for CRYGN Gene

Aliases for CRYGN Gene

  • Crystallin Gamma N 2 3 5
  • Gamma-N-Crystallin 3 4
  • Crystallin, Gamma N 2
  • Gamma-Crystallin N 3
  • GammaN-Crystallin 3

External Ids for CRYGN Gene

Previous GeneCards Identifiers for CRYGN Gene

  • GC07M149373
  • GC07M150440
  • GC07M150517
  • GC07M150564
  • GC07M150757
  • GC07M151125
  • GC07M144938

Summaries for CRYGN Gene

Entrez Gene Summary for CRYGN Gene

  • This gene encodes a member of the crystallin family of proteins that are localized to the refractive structure of vertebrate eye lenses. The protein encoded by this gene is unique in that it has both beta and gamma crystallin protein motifs. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2015]

GeneCards Summary for CRYGN Gene

CRYGN (Crystallin Gamma N) is a Protein Coding gene. An important paralog of this gene is CRYBA2.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRYGN Gene

Genomics for CRYGN Gene

Regulatory Elements for CRYGN Gene

Enhancers for CRYGN Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F151371 0.3 FANTOM5 14.2 +76.9 76916 0.3 ZNF121 TAL1 CRYGN SMARCD3 RHEB LOC105375569 WDR86 GC07M151365 PIR52552
GH07F151365 0.5 Ensembl ENCODE 11.8 +81.3 81254 3.5 HDGF PKNOX1 ATF1 MLX ARNT ARID4B SIN3A DMAP1 ZNF48 ZNF2 WDR86-AS1 WDR86 CRYGN ENSG00000241456 RHEB SMARCD3 LOC105375569 NUB1 GC07M151365 GC07P151348
GH07F151411 0.8 ENCODE 11.7 +36.6 36570 0.2 CTCF ZNF362 CBX3 MAX ZEB2 REST FOXK2 POLR2A GLIS1 IKZF1 CRYGN WDR86 ENSG00000241456
GH07F151470 1 Ensembl ENCODE 11.5 -24.0 -24029 3.4 HDGF ATF1 PKNOX1 ARNT WRNIP1 SIN3A YBX1 ZNF2 ZNF121 GLIS2 ENSG00000244151 CRYGN RHEB RN7SL76P GC07P151497
GH07F151467 0.2 ENCODE 11.4 -20.0 -20020 1.7 KLF1 PRDM1 CRYGN RHEB RN7SL76P GC07P151497
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CRYGN on UCSC Golden Path with GeneCards custom track

Genomic Location for CRYGN Gene

151,428,835 bp from pter
151,448,419 bp from pter
19,585 bases
Minus strand

Genomic View for CRYGN Gene

Genes around CRYGN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRYGN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRYGN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRYGN Gene

Proteins for CRYGN Gene

  • Protein details for CRYGN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Gamma-crystallin N
    Protein Accession:
    Secondary Accessions:
    • Q496G6

    Protein attributes for CRYGN Gene

    182 amino acids
    Molecular mass:
    20624 Da
    Quaternary structure:
    • Monomer.

    Alternative splice isoforms for CRYGN Gene


neXtProt entry for CRYGN Gene

Post-translational modifications for CRYGN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CRYGN Gene

No data available for DME Specific Peptides for CRYGN Gene

Domains & Families for CRYGN Gene

Gene Families for CRYGN Gene

Protein Domains for CRYGN Gene

Suggested Antigen Peptide Sequences for CRYGN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 3 beta/gamma crystallin Greek key domains.
  • Belongs to the beta/gamma-crystallin family.
  • Contains 3 beta/gamma crystallin Greek key domains.
  • Belongs to the beta/gamma-crystallin family.
genes like me logo Genes that share domains with CRYGN: view

Function for CRYGN Gene

genes like me logo Genes that share phenotypes with CRYGN: view

Animal Model Products

miRNA for CRYGN Gene

miRTarBase miRNAs that target CRYGN

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CRYGN Gene

Localization for CRYGN Gene

Subcellular locations from

Jensen Localization Image for CRYGN Gene COMPARTMENTS Subcellular localization image for CRYGN gene
Compartment Confidence
cytosol 2
extracellular 2
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CRYGN Gene

Pathways & Interactions for CRYGN Gene

SuperPathways for CRYGN Gene

No Data Available

Interacting Proteins for CRYGN Gene

Gene Ontology (GO) - Biological Process for CRYGN Gene


No data available for Pathways by source and SIGNOR curated interactions for CRYGN Gene

Transcripts for CRYGN Gene

mRNA/cDNA for CRYGN Gene

Unigene Clusters for CRYGN Gene

Crystallin, gamma N:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CRYGN Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c
SP1: - -
SP2: - -

Relevant External Links for CRYGN Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CRYGN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CRYGN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CRYGN Gene

This gene is overexpressed in Thyroid (x21.9).

NURSA nuclear receptor signaling pathways regulating expression of CRYGN Gene:


SOURCE GeneReport for Unigene cluster for CRYGN Gene:


mRNA Expression by UniProt/SwissProt for CRYGN Gene:

Tissue specificity: Not specifically expressed in eye.
genes like me logo Genes that share expression patterns with CRYGN: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for CRYGN Gene

Orthologs for CRYGN Gene

This gene was present in the common ancestor of chordates.

Orthologs for CRYGN Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CRYGN 34 35
  • 98.53 (n)
(Mus musculus)
Mammalia Crygn 34 16 35
  • 89.21 (n)
(Rattus norvegicus)
Mammalia Crygn 34
  • 88.51 (n)
(Bos Taurus)
Mammalia CRYGN 34 35
  • 88.49 (n)
(Canis familiaris)
Mammalia CRYGN 34 35
  • 85.37 (n)
(Monodelphis domestica)
Mammalia CRYGN 35
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia CRYGN 35
  • 45 (a)
(Gallus gallus)
Aves CRYGN 34 35
  • 70.74 (n)
(Anolis carolinensis)
Reptilia CRYGN 35
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia crygn 34
  • 76.26 (n)
(Danio rerio)
Actinopterygii crygn1 34 35
  • 72.9 (n)
crygn2 35
  • 50 (a)
CRYGN (2 of 3) 35
  • 26 (a)
Dr.29203 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13121 34
Species where no ortholog for CRYGN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CRYGN Gene

Gene Tree for CRYGN (if available)
Gene Tree for CRYGN (if available)

Paralogs for CRYGN Gene

(9) SIMAP similar genes for CRYGN Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CRYGN: view

Variants for CRYGN Gene

Sequence variations from dbSNP and Humsavar for CRYGN Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10226298 -- 151,440,354(+) CTGCA(A/G)GTAGT intron-variant, nc-transcript-variant, upstream-variant-2KB
rs10230645 -- 151,432,589(+) TCTTG(C/T)AGTCA intron-variant
rs10230767 -- 151,432,664(+) CTGGG(C/T)GTGGT intron-variant
rs10252902 -- 151,434,725(+) CAGTA(A/G)GTTCT intron-variant, upstream-variant-2KB
rs10255671 -- 151,440,647(+) GGGTG(A/C)CCAGG intron-variant, nc-transcript-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CRYGN Gene

Variant ID Type Subtype PubMed ID
dgv3695n106 OTHER inversion 24896259
nsv1067934 OTHER inversion 25765185
nsv1151906 OTHER inversion 26484159
nsv6006 CNV insertion 18451855

Variation tolerance for CRYGN Gene

Residual Variation Intolerance Score: 81.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.13; 51.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CRYGN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRYGN Gene

Disorders for CRYGN Gene

Relevant External Links for CRYGN

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CRYGN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CRYGN Gene

Publications for CRYGN Gene

  1. Genetics of crystallins: cataract and beyond. (PMID: 19007775) Graw J. (Exp. Eye Res. 2009) 3 22 64
  2. Gamma-N-crystallin and the evolution of the betagamma-crystallin superfamily in vertebrates. (PMID: 15853812) Wistow G. … Vihtelic T. (FEBS J. 2005) 3 4 64
  3. Prenatal tobacco smoke exposure is associated with childhood DNA CpG methylation. (PMID: 24964093) Breton C.V. … Raby B. (PLoS ONE 2014) 3 64
  4. Non-EST-based prediction of novel alternatively spliced cassette exons with cell signaling function in Caenorhabditis elegans and human. (PMID: 17452356) Leparc G.G. … Mitra R.D. (Nucleic Acids Res. 2007) 3 64
  5. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3 64

Products for CRYGN Gene

Sources for CRYGN Gene

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