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Aliases for CRYGN Gene

Aliases for CRYGN Gene

  • Crystallin, Gamma N 2 3
  • Gamma-N-Crystallin 3 4
  • Gamma-Crystallin N 3
  • GammaN-Crystallin 3

External Ids for CRYGN Gene

Summaries for CRYGN Gene

Entrez Gene Summary for CRYGN Gene

  • The beta and gamma crystallins are evolutionarily related families of proteins that are localized to the refractive structure of the eye lens. The protein encoded by this gene is unique in that it has both beta and gamma crystallin protein motifs. [provided by RefSeq, Jul 2008]

GeneCards Summary for CRYGN Gene

CRYGN (Crystallin, Gamma N) is a Protein Coding gene. An important paralog of this gene is CRYGC.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRYGN Gene

Genomics for CRYGN Gene

Genomic Location for CRYGN Gene

Start:
151,428,835 bp from pter
End:
151,440,813 bp from pter
Size:
11,979 bases
Orientation:
Minus strand

Genomic View for CRYGN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CRYGN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRYGN Gene

Regulatory Elements for CRYGN Gene

Proteins for CRYGN Gene

  • Protein details for CRYGN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WXF5-CRGN_HUMAN
    Recommended name:
    Gamma-crystallin N
    Protein Accession:
    Q8WXF5
    Secondary Accessions:
    • Q496G6

    Protein attributes for CRYGN Gene

    Size:
    182 amino acids
    Molecular mass:
    20624 Da
    Quaternary structure:
    • Monomer.

    Alternative splice isoforms for CRYGN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CRYGN Gene

Proteomics data for CRYGN Gene at MOPED

Post-translational modifications for CRYGN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CRYGN Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CRYGN Gene

Domains for CRYGN Gene

Protein Domains for CRYGN Gene

UniProtKB/Swiss-Prot:

CRGN_HUMAN
Domain:
  • Contains 3 beta/gamma crystallin Greek key domains.:
    • Q8WXF5
Family:
  • Belongs to the beta/gamma-crystallin family.:
    • Q8WXF5
genes like me logo Genes that share domains with CRYGN: view

No data available for Gene Families for CRYGN Gene

Function for CRYGN Gene

miRNA for CRYGN Gene

miRTarBase miRNAs that target CRYGN

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CRYGN Gene

Localization for CRYGN Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CRYGN Gene COMPARTMENTS Subcellular localization image for CRYGN gene
Compartment Confidence
cytosol 2
extracellular 2
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for CRYGN Gene

Pathways for CRYGN Gene

SuperPathways for CRYGN Gene

No Data Available

Interacting Proteins for CRYGN Gene

Gene Ontology (GO) - Biological Process for CRYGN Gene

None

No data available for Pathways by source for CRYGN Gene

Transcripts for CRYGN Gene

mRNA/cDNA for CRYGN Gene

(5) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CRYGN Gene

Crystallin, gamma N:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CRYGN Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c
SP1: - -
SP2: - -
SP3:

Relevant External Links for CRYGN Gene

GeneLoc Exon Structure for
CRYGN
ECgene alternative splicing isoforms for
CRYGN

Expression for CRYGN Gene

mRNA expression in normal human tissues for CRYGN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CRYGN Gene

This gene is overexpressed in Thyroid (21.9).

SOURCE GeneReport for Unigene cluster for CRYGN Gene Hs.647104

mRNA Expression by UniProt/SwissProt for CRYGN Gene

Q8WXF5-CRGN_HUMAN
Tissue specificity: Not specifically expressed in eye.
genes like me logo Genes that share expressions with CRYGN: view

Orthologs for CRYGN Gene

This gene was present in the common ancestor of chordates.

Orthologs for CRYGN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CRYGN 36
  • 98.53 (n)
  • 97.8 (a)
CRYGN 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CRYGN 36
  • 88.49 (n)
  • 89.93 (a)
CRYGN 37
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CRYGN 36
  • 85.37 (n)
  • 84.89 (a)
CRYGN 37
  • 67 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Crygn 36
  • 89.21 (n)
  • 89.93 (a)
Crygn 16
Crygn 37
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CRYGN 37
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CRYGN 37
  • 45 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Crygn 36
  • 88.51 (n)
  • 87.93 (a)
chicken
(Gallus gallus)
Aves CRYGN 36
  • 70.74 (n)
  • 61.87 (a)
CRYGN 37
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CRYGN 37
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia crygn 36
  • 76.26 (n)
  • 77.7 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13121 36
zebrafish
(Danio rerio)
Actinopterygii CRYGN (2 of 3) 37
  • 26 (a)
OneToMany
crygn1 36
  • 72.9 (n)
  • 74.1 (a)
crygn1 37
  • 58 (a)
OneToMany
crygn2 37
  • 50 (a)
OneToMany
Dr.29203 36
Species with no ortholog for CRYGN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CRYGN Gene

ENSEMBL:
Gene Tree for CRYGN (if available)
TreeFam:
Gene Tree for CRYGN (if available)

Paralogs for CRYGN Gene

Selected SIMAP similar genes for CRYGN Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CRYGN: view

Variants for CRYGN Gene

Sequence variations from dbSNP and Humsavar for CRYGN Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs2074999 -- 151,438,371(-) TGTGC(A/G)GCAGG intron-variant
rs2075000 -- 151,436,706(-) CAGAA(C/T)CCGGA intron-variant
rs2075001 -- 151,436,185(-) GGGGA(C/T)GGAGC reference, synonymous-codon, downstream-variant-500B
rs2075003 -- 151,432,386(-) GCTCG(A/G)CCGGG intron-variant
rs4726025 -- 151,432,813(+) CTGCA(C/T)GCCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CRYGN Gene

Variant ID Type Subtype PubMed ID
nsv6006 CNV Insertion 18451855

Relevant External Links for CRYGN Gene

HapMap Linkage Disequilibrium report
CRYGN

Disorders for CRYGN Gene

No disorders were found for CRYGN Gene.

No data available for UniProtKB/Swiss-Prot for CRYGN Gene

Publications for CRYGN Gene

  1. Gamma-N-crystallin and the evolution of the betagamma-crystallin superfamily in vertebrates. (PMID: 15853812) Wistow G. … Vihtelic T. (FEBS J. 2005) 3 4
  2. Non-EST-based prediction of novel alternatively spliced cassette exons with cell signaling function in Caenorhabditis elegans and human. (PMID: 17452356) Leparc G.G. … Mitra R.D. (Nucleic Acids Res. 2007) 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  4. Genetics of crystallins: cataract and beyond. (PMID: 19007775) Graw J. (Exp. Eye Res. 2009) 23
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for CRYGN Gene

Sources for CRYGN Gene

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