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Aliases for CRYGN Gene

Aliases for CRYGN Gene

  • Crystallin, Gamma N 2 3
  • Gamma-N-Crystallin 3 4
  • GammaN-Crystallin 3

External Ids for CRYGN Gene

Previous GeneCards Identifiers for CRYGN Gene

  • GC07M149373
  • GC07M150440
  • GC07M150517
  • GC07M150564
  • GC07M150757
  • GC07M151125
  • GC07M144938

Summaries for CRYGN Gene

Entrez Gene Summary for CRYGN Gene

  • This gene encodes a member of the crystallin family of proteins that are localized to the refractive structure of vertebrate eye lenses. The protein encoded by this gene is unique in that it has both beta and gamma crystallin protein motifs. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2015]

GeneCards Summary for CRYGN Gene

CRYGN (Crystallin, Gamma N) is a Protein Coding gene. An important paralog of this gene is CRYGC.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRYGN Gene

Genomics for CRYGN Gene

Regulatory Elements for CRYGN Gene

Genomic Location for CRYGN Gene

151,428,835 bp from pter
151,448,419 bp from pter
19,585 bases
Minus strand

Genomic View for CRYGN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CRYGN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRYGN Gene

Proteins for CRYGN Gene

  • Protein details for CRYGN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Gamma-crystallin N
    Protein Accession:
    Secondary Accessions:
    • Q496G6

    Protein attributes for CRYGN Gene

    182 amino acids
    Molecular mass:
    20624 Da
    Quaternary structure:
    • Monomer.

    Alternative splice isoforms for CRYGN Gene


neXtProt entry for CRYGN Gene

Proteomics data for CRYGN Gene at MOPED

Post-translational modifications for CRYGN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CRYGN Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CRYGN Gene

Domains & Families for CRYGN Gene

Protein Domains for CRYGN Gene

Suggested Antigen Peptide Sequences for CRYGN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 3 beta/gamma crystallin Greek key domains.
  • Belongs to the beta/gamma-crystallin family.
  • Contains 3 beta/gamma crystallin Greek key domains.
  • Belongs to the beta/gamma-crystallin family.
genes like me logo Genes that share domains with CRYGN: view

No data available for Gene Families for CRYGN Gene

Function for CRYGN Gene

Phenotypes for CRYGN Gene

GenomeRNAi human phenotypes for CRYGN:
genes like me logo Genes that share phenotypes with CRYGN: view

miRNA for CRYGN Gene

miRTarBase miRNAs that target CRYGN

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CRYGN

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for CRYGN Gene

Localization for CRYGN Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for CRYGN Gene

Pathways & Interactions for CRYGN Gene

SuperPathways for CRYGN Gene

No Data Available

Interacting Proteins for CRYGN Gene

Gene Ontology (GO) - Biological Process for CRYGN Gene


No data available for Pathways by source and SIGNOR curated interactions for CRYGN Gene

Drugs & Compounds for CRYGN Gene

No Compound Related Data Available

Transcripts for CRYGN Gene

mRNA/cDNA for CRYGN Gene

(6) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CRYGN Gene

Crystallin, gamma N:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CRYGN

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CRYGN Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c
SP1: - -
SP2: - -

Relevant External Links for CRYGN Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CRYGN Gene

mRNA expression in normal human tissues for CRYGN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CRYGN Gene

This gene is overexpressed in Thyroid (x21.9).

SOURCE GeneReport for Unigene cluster for CRYGN Gene Hs.647104

mRNA Expression by UniProt/SwissProt for CRYGN Gene

Tissue specificity: Not specifically expressed in eye.
genes like me logo Genes that share expression patterns with CRYGN: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for CRYGN Gene

Orthologs for CRYGN Gene

This gene was present in the common ancestor of chordates.

Orthologs for CRYGN Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CRYGN 35
  • 88.49 (n)
  • 89.93 (a)
  • 73 (a)
(Canis familiaris)
Mammalia CRYGN 35
  • 85.37 (n)
  • 84.89 (a)
  • 67 (a)
(Mus musculus)
Mammalia Crygn 35
  • 89.21 (n)
  • 89.93 (a)
Crygn 16
Crygn 36
  • 72 (a)
(Pan troglodytes)
Mammalia CRYGN 35
  • 98.53 (n)
  • 97.8 (a)
  • 98 (a)
(Rattus norvegicus)
Mammalia Crygn 35
  • 88.51 (n)
  • 87.93 (a)
(Monodelphis domestica)
Mammalia CRYGN 36
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia CRYGN 36
  • 45 (a)
(Gallus gallus)
Aves CRYGN 35
  • 70.74 (n)
  • 61.87 (a)
  • 50 (a)
(Anolis carolinensis)
Reptilia CRYGN 36
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia crygn 35
  • 76.26 (n)
  • 77.7 (a)
(Danio rerio)
Actinopterygii crygn1 35
  • 72.9 (n)
  • 74.1 (a)
Dr.29203 35
CRYGN (2 of 3) 36
  • 26 (a)
crygn1 36
  • 58 (a)
crygn2 36
  • 50 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13121 35
Species with no ortholog for CRYGN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CRYGN Gene

Gene Tree for CRYGN (if available)
Gene Tree for CRYGN (if available)

Paralogs for CRYGN Gene

(9) SIMAP similar genes for CRYGN Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CRYGN: view

Variants for CRYGN Gene

Sequence variations from dbSNP and Humsavar for CRYGN Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs2074999 -- 151,438,371(-) TGTGC(A/G)GCAGG intron-variant
rs2075000 -- 151,436,706(-) CAGAA(C/T)CCGGA intron-variant
rs2075001 -- 151,436,185(-) GGGGA(C/T)GGAGC reference, synonymous-codon, downstream-variant-500B
rs2075003 -- 151,432,386(-) GCTCG(A/G)CCGGG intron-variant
rs4360209 -- 151,449,100(+) GCACC(A/C)ACTAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CRYGN Gene

Variant ID Type Subtype PubMed ID
nsv6006 CNV Insertion 18451855

Variation tolerance for CRYGN Gene

Residual Variation Intolerance Score: 81.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.13; 51.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CRYGN Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRYGN Gene

Disorders for CRYGN Gene

Relevant External Links for CRYGN

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CRYGN: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CRYGN Gene

Publications for CRYGN Gene

  1. Genetics of crystallins: cataract and beyond. (PMID: 19007775) Graw J. (Exp. Eye Res. 2009) 23 67
  2. Prenatal tobacco smoke exposure is associated with childhood DNA CpG methylation. (PMID: 24964093) Breton C.V. … Raby B. (PLoS ONE 2014) 67
  3. Non-EST-based prediction of novel alternatively spliced cassette exons with cell signaling function in Caenorhabditis elegans and human. (PMID: 17452356) Leparc G.G. … Mitra R.D. (Nucleic Acids Res. 2007) 67
  4. Gamma-N-crystallin and the evolution of the betagamma-crystallin superfamily in vertebrates. (PMID: 15853812) Wistow G. … Vihtelic T. (FEBS J. 2005) 67
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67

Products for CRYGN Gene

Sources for CRYGN Gene

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