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Aliases for CRYGN Gene

Aliases for CRYGN Gene

  • Crystallin Gamma N 2 3 5
  • Gamma-N-Crystallin 3 4
  • Crystallin, Gamma N 2
  • Gamma-Crystallin N 3
  • GammaN-Crystallin 3

External Ids for CRYGN Gene

Previous GeneCards Identifiers for CRYGN Gene

  • GC07M149373
  • GC07M150440
  • GC07M150517
  • GC07M150564
  • GC07M150757
  • GC07M151125
  • GC07M144938

Summaries for CRYGN Gene

Entrez Gene Summary for CRYGN Gene

  • This gene encodes a member of the crystallin family of proteins that are localized to the refractive structure of vertebrate eye lenses. The protein encoded by this gene is unique in that it has both beta and gamma crystallin protein motifs. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2015]

GeneCards Summary for CRYGN Gene

CRYGN (Crystallin Gamma N) is a Protein Coding gene. An important paralog of this gene is CRYBA2.

Additional gene information for CRYGN Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRYGN Gene

Genomics for CRYGN Gene

Regulatory Elements for CRYGN Gene

Enhancers for CRYGN Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H151456 1.5 FANTOM5 Ensembl ENCODE 10.2 -10.9 -10922 6 SIN3A FEZF1 ZNF2 ZNF766 GLIS2 PPARG ZNF592 SREBF1 MAFF ZNF585B NUB1 ENSG00000241456 SMARCD3 CRYGN RHEB GC07M151465
GH07H151365 1.2 Ensembl ENCODE 11.8 +81.3 81254 3 HDGF ATF1 ZNF2 YY1 ZNF143 ZNF207 FOS ATF7 RUNX3 REST WDR86-AS1 WDR86 CRYGN ENSG00000241456 RHEB SMARCD3 ENSG00000243018 NUB1 GC07M151365 GC07P151348
GH07H151484 1.2 FANTOM5 Ensembl ENCODE 10.9 -37.2 -37159 1 FOSL1 JUND HDAC2 FOS ELF1 ZNF24 CRYGN AGAP3 PRKAG2 GC07P151497 RN7SL76P
GH07H151348 1.3 Ensembl ENCODE 10 +97.5 97501 4 HDGF PKNOX1 FOXA2 ARNT ARID4B ZNF2 ZNF766 ZNF143 ZNF207 SP3 CRYGN NUB1 GC07P151348 GC07M151365
GH07H151424 1.3 Ensembl ENCODE 8.6 +20.6 20577 6 HDGF FEZF1 GLI4 ZNF2 GLIS2 FOS RUNX3 TSHZ1 SMARCB1 ZNF518A WDR86 ENSG00000241456 CRYGN WDR86-AS1 MIR3907
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CRYGN on UCSC Golden Path with GeneCards custom track

Genomic Location for CRYGN Gene

151,428,835 bp from pter
151,448,419 bp from pter
19,585 bases
Minus strand

Genomic View for CRYGN Gene

Genes around CRYGN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRYGN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRYGN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRYGN Gene

Proteins for CRYGN Gene

  • Protein details for CRYGN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Gamma-crystallin N
    Protein Accession:
    Secondary Accessions:
    • Q496G6

    Protein attributes for CRYGN Gene

    182 amino acids
    Molecular mass:
    20624 Da
    Quaternary structure:
    • Monomer.

    Alternative splice isoforms for CRYGN Gene


neXtProt entry for CRYGN Gene

Post-translational modifications for CRYGN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CRYGN Gene

No data available for DME Specific Peptides for CRYGN Gene

Domains & Families for CRYGN Gene

Gene Families for CRYGN Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CRYGN Gene

Suggested Antigen Peptide Sequences for CRYGN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the beta/gamma-crystallin family.
  • Belongs to the beta/gamma-crystallin family.
genes like me logo Genes that share domains with CRYGN: view

Function for CRYGN Gene

Phenotypes From GWAS Catalog for CRYGN Gene

genes like me logo Genes that share phenotypes with CRYGN: view

Animal Model Products

CRISPR Products

miRNA for CRYGN Gene

miRTarBase miRNAs that target CRYGN

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CRYGN
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CRYGN Gene

Localization for CRYGN Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CRYGN gene
Compartment Confidence
extracellular 2
nucleus 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for CRYGN Gene

Pathways & Interactions for CRYGN Gene

SuperPathways for CRYGN Gene

No Data Available

Interacting Proteins for CRYGN Gene

Gene Ontology (GO) - Biological Process for CRYGN Gene


No data available for Pathways by source and SIGNOR curated interactions for CRYGN Gene

Drugs & Compounds for CRYGN Gene

No Compound Related Data Available

Transcripts for CRYGN Gene

mRNA/cDNA for CRYGN Gene

Unigene Clusters for CRYGN Gene

Crystallin, gamma N:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CRYGN
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for CRYGN Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c
SP1: - -
SP2: - -

Relevant External Links for CRYGN Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CRYGN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CRYGN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CRYGN Gene

This gene is overexpressed in Thyroid (x21.9).

NURSA nuclear receptor signaling pathways regulating expression of CRYGN Gene:


SOURCE GeneReport for Unigene cluster for CRYGN Gene:


mRNA Expression by UniProt/SwissProt for CRYGN Gene:

Tissue specificity: Not specifically expressed in eye.
genes like me logo Genes that share expression patterns with CRYGN: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CRYGN Gene

Orthologs for CRYGN Gene

This gene was present in the common ancestor of chordates.

Orthologs for CRYGN Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CRYGN 33 34
  • 98.53 (n)
(Mus musculus)
Mammalia Crygn 33 16 34
  • 89.21 (n)
(Rattus norvegicus)
Mammalia Crygn 33
  • 88.51 (n)
(Bos Taurus)
Mammalia CRYGN 33 34
  • 88.49 (n)
(Canis familiaris)
Mammalia CRYGN 33 34
  • 85.37 (n)
(Monodelphis domestica)
Mammalia CRYGN 34
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia CRYGN 34
  • 45 (a)
(Gallus gallus)
Aves CRYGN 33 34
  • 70.74 (n)
(Anolis carolinensis)
Reptilia CRYGN 34
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia crygn 33
  • 76.26 (n)
(Danio rerio)
Actinopterygii crygn1 33 34
  • 72.9 (n)
crygn2 34
  • 50 (a)
CRYGN (2 of 3) 34
  • 26 (a)
Dr.29203 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13121 33
Species where no ortholog for CRYGN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CRYGN Gene

Gene Tree for CRYGN (if available)
Gene Tree for CRYGN (if available)

Paralogs for CRYGN Gene

(9) SIMAP similar genes for CRYGN Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CRYGN: view

Variants for CRYGN Gene

Sequence variations from dbSNP and Humsavar for CRYGN Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000044490 -- 151,449,033(+) GCGGG(G/T)GCCAC upstream-variant-2KB
rs1000129970 -- 151,446,067(+) CCACG(A/G)TCATA intron-variant
rs1000272069 -- 151,431,848(+) CCCCA(A/G)GCGAG intron-variant, reference, missense
rs1000333437 -- 151,448,544(+) AAGAG(C/T)CCGGT utr-variant-5-prime
rs1000336052 -- 151,442,257(+) TATGC(C/T)TTTCT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CRYGN Gene

Variant ID Type Subtype PubMed ID
dgv3695n106 OTHER inversion 24896259
nsv1067934 OTHER inversion 25765185
nsv1151906 OTHER inversion 26484159
nsv6006 CNV insertion 18451855

Variation tolerance for CRYGN Gene

Residual Variation Intolerance Score: 81.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.13; 51.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CRYGN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRYGN Gene

Disorders for CRYGN Gene

Relevant External Links for CRYGN

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CRYGN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CRYGN Gene

Publications for CRYGN Gene

  1. Genetics of crystallins: cataract and beyond. (PMID: 19007775) Graw J (Experimental eye research 2009) 3 22 60
  2. gammaN-crystallin and the evolution of the betagamma-crystallin superfamily in vertebrates. (PMID: 15853812) Wistow G … Vihtelic T (The FEBS journal 2005) 3 4 60
  3. Prenatal tobacco smoke exposure is associated with childhood DNA CpG methylation. (PMID: 24964093) Breton CV … Asthma BRIDGE consortium (PloS one 2014) 3 60
  4. Non-EST-based prediction of novel alternatively spliced cassette exons with cell signaling function in Caenorhabditis elegans and human. (PMID: 17452356) Leparc GG … Mitra RD (Nucleic acids research 2007) 3 60
  5. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R … Stanton LW (Nature biotechnology 2004) 3 60

Products for CRYGN Gene

Sources for CRYGN Gene

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