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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CRYGD Gene

protein-coding   GIFtS: 54
GCID: GC02M208986

Crystallin, Gamma D


(Previous symbol: CRYG4)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Crystallin, Gamma D1 2     PCC2
CRYG41 2 3 5     cry-g-D2
Gamma-Crystallin 42 3     Gamma Crystallin 42
CCP2 5     gamma-D-crystallin2
CACA2     Gamma-Crystallin D2
CCA32     Gamma-D-crystallin3
CTRCT42     

External Ids:    HGNC: 24111   Entrez Gene: 14212   Ensembl: ENSG000001182317   OMIM: 1236905   UniProtKB: P073203   

Export aliases for CRYGD gene to outside databases

Previous GC identifers: GC02M207153 GC02M207698 GC02M208950 GC02M209189 GC02M209190 GC02M208811 GC02M208694 GC02M200834


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CRYGD Gene:
Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class
constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the
lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then
retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into
alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta
families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four
homologous motifs, a connecting peptide, and N- and C-terminal extensions. Gamma-crystallins are a homogeneous
group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions.
They are differentially regulated after early development. Four gamma-crystallin genes (gamma-A through gamma-D)
and three pseudogenes (gamma-E, gamma-F, gamma-G) are tandemly organized in a genomic segment as a gene cluster.
Whether due to aging or mutations in specific genes, gamma-crystallins have been involved in cataract formation.
(provided by RefSeq, Jul 2008)

GeneCards Summary for CRYGD Gene: 
CRYGD (crystallin, gamma D) is a protein-coding gene. Diseases associated with CRYGD include cataract, congenital, cerulean type, 3, and cataract, nonnuclear polymorphic congenital. GO annotations related to this gene include protein binding and structural constituent of eye lens. An important paralog of this gene is CRYBB3.

UniProtKB/Swiss-Prot: CRGD_HUMAN, P07320
Function: Crystallins are the dominant structural components of the vertebrate eye lens

Gene Wiki entry for CRYGD (Crystallin, gamma D) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CRYGD gene promoter:
         Bach1   NF-1   Tal-1beta   Evi-1   E47   C/EBPalpha   CHOP-10   PPAR-gamma1   PPAR-gamma2   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCRYGD promoter sequence
   Search SABiosciences Chromatin IP Primers for CRYGD

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CRYGD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q33.3   Ensembl cytogenetic band:  2q33.3   HGNC cytogenetic band: 2q33.3

CRYGD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRYGD gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M208986:  view genomic region     (about GC identifiers)

Start:
208,986,331 bp from pter      End:
208,989,313 bp from pter
Size:
2,983 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CRGD_HUMAN, P07320 (See protein sequence)
Recommended Name: Gamma-crystallin D  
Size: 174 amino acids; 20738 Da
Subunit: Monomer (By similarity)
6/8 PDB 3D structures from and Proteopedia for CRYGD (see all 8):
1H4A (3D)        1HK0 (3D)        1LD0 (3D)        2G98 (3D)        2KFB (3D)        2KLJ (3D)    
Secondary accessions: Q17RF7 Q53R51 Q99681

Explore the universe of human proteins at neXtProt for CRYGD: NX_P07320

Explore proteomics data for CRYGD at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P07320

  • CRYGD Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CRYGD Protein Expression
    REFSEQ proteins: NP_008822.2  
    ENSEMBL proteins: 
     ENSP00000264376  

    Human Recombinant Protein Products for CRYGD: 
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    Novus Biologicals CRYGD Lysates
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    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for CRYGD
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm ISS--

    CRYGD for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR001064 Beta/gamma_crystallin
     IPR011024 G_crystallin-rel

    Graphical View of Domain Structure for InterPro Entry P07320

    ProtoNet protein and cluster: P07320

    2 Blocks protein domains:
    IPB001064 Beta and gamma crystallin
    IPB011024 Gamma-crystallin related


    UniProtKB/Swiss-Prot: CRGD_HUMAN, P07320
    Domain: Has a two-domain beta-structure, folded into four very similar Greek key motifs
    Similarity: Belongs to the beta/gamma-crystallin family
    Similarity: Contains 4 beta/gamma crystallin 'Greek key' domains


    CRYGD for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CRGD_HUMAN, P07320
    Function: Crystallins are the dominant structural components of the vertebrate eye lens

         Genatlas biochemistry entry for CRYGD:
    crystallin,gamma polypeptide D

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005212structural constituent of eye lens NAS12507494
    GO:0005515protein binding IPI--
         
    CRYGD for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CRYGD:
     Decreased circadian period len 

         1 MGI mutant phenotype (inferred from 6 alleles(MGI details for Crygd):
     vision/eye 

    CRYGD for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CRYGD 
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    hsa-miR-873
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CRYGD

    2 Interacting proteins for CRYGD (P073202) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    --P239272MINT-8303035 MINT-8303102
    --P246232MINT-8303127 MINT-8303079
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002088lens development in camera-type eye ISS--
    GO:0007601visual perception IMP12011157
    GO:0034614cellular response to reactive oxygen species IDA8943244
    GO:0070306lens fiber cell differentiation ISS--

    CRYGD for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CRYGD for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CRYGD (CRGD)

    2 Novoseek inferred chemical compound relationships for CRYGD gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    proline 35.1 2 15041957 (1)
    threonine 29.8 2 15041957 (1)

    Search CenterWatch for drugs/clinical trials and news about CRYGD / CRGD

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CRYGD gene: 
    NM_006891.3  

    Unigene Cluster for CRYGD:

    Crystallin, gamma D
    Hs.546247  [show with all ESTs]
    Unigene Representative Sequence: CD049752
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000264376(uc002vcn.4 uc021vvu.1)
    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate CRYGD:
    hsa-miR-873
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CRYGD
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRYGD

    Additional mRNA sequence: 

    BC117338.1 BC117340.1 U66583.1 

    1 DOTS entry:

    DT.87046545 

    22 AceView cDNA sequences:

    BF726960 BM696817 BM670075 CD674533 BF727389 U66583 BM712147 BF727444 
    BM670210 NM_006891 BF726365 CD676210 BM699428 BF726635 CD674683 CD675943 
    BG152794 BF727241 BU735399 CD049752 BX282705 BU734844 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CRYGD expression in normal human tissues (normalized intensities)      CRYGD embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGAAGATCA
    CRYGD Expression
    About this image


    CRYGD expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/9 selected tissues (see all 9) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 7 entries
             Zeugopod Long Bone
             skeleton/pectoral girdle and thoracic body wall/scapula   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 3 entries
             Meckel's Cartilage
             skeleton/cranium/chondrocranium   
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 2 entries
             skeleton/cranium/chondrocranium   
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             Pelvic Girdle
     
     Eye (Sensory Organs)
             lens   

    See CRYGD Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CRYGD

    SOURCE GeneReport for Unigene cluster: Hs.546247
        SABiosciences Custom PCR Arrays for CRYGD
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRYGD

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CRYGD gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Crygd1 , 5 crystallin, gamma D1, 5 88.63(n)1
    84.97(a)1
      1 (32.80 cM)5
    129671  NM_007776.21  NP_031802.21 
     650618725 
    African clawed frog
    (Xenopus laevis)
    Amphibia CB198197.22   -- 75.3(n)    CB198197.2 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.189372 Transcribed sequence with weak similarity to protein spP07316 (H.sapiens) CRGB_HUMAN GAMMA CRYSTALLIN B (GAMMA CRYSTALLIN 1-2) less 72.01(n)    CK352454.1 


    ENSEMBL Gene Tree for CRYGD (if available)
    TreeFam Gene Tree for CRYGD (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CRYGD gene
    CRYBB32  CRYGB2  CRYBA42  CRYBA12  CRYBB22  CRYGA2  CRYBB12  CRYGC2  
    CRYBA22  CRYGN2  CRYGS2  
    16 SIMAP similar genes for CRYGD using alignment to 1 protein entry:     CRGD_HUMAN:
    CRYGB    CRYGC    CRYGA    CRYGS    DKFZp434A0627    CRYBA1
    CRYBB3    CRYGN    CRYBB1    CRYBB2    CRYBA4    AIM1
    DKFZp434L1713    AIM1L    CRYBA2    CRYBG3

    CRYGD for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for CRYGD
    PGOHUM00000240041 PGOHUM00000240506 PGOHUM00000241095 PGOHUM00000233083


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/158 SNPs in CRYGD are shown (see all 158)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0648294
    Cataract 4, multiple types (CTRCT4)4--see VAR_0648292 W R mis40--------
    VAR_0211454
    Cataract 4, multiple types (CTRCT4)4--see VAR_0211452 P T mis40--------
    VAR_0107344
    Cataract 4, multiple types (CTRCT4)4--see VAR_0107342 R S mis40--------
    VAR_0107354
    Cataract 4, multiple types (CTRCT4)4--see VAR_0107352 R H mis40--------
    VAR_0349564
    Cataract 4, multiple types (CTRCT4)4--see VAR_0349562 E A mis40--------
    VAR_0107334
    Cataract 4, multiple types (CTRCT4)4--see VAR_0107332 R C mis40--------
    rs289316051,2,4
    CCataract 4, multiple types (CTRCT4)4 pathogenic1208377460(-) ACCACA/C/TCCAAC 3 T P S mis1 ese30--------
    rs23054301,2
    C,F,Huntested1208375084(+) TCCTCC/TCTCTC 2 R syn1 ese3 trp330Minor allele frequency- T:0.19EA NA NS WA CSA EU 9816
    rs22420741,2
    C,F,Huntested1208377479(+) CATTCG/ATAGTG 2 /Y syn1 ese325Minor allele frequency- A:0.39NS EA NA CSA WA EU 5502
    VAR_0211464
    ----see VAR_0211462 M V mis40--------

    HapMap Linkage Disequilibrium report for CRYGD (208986331 - 208989313 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CRYGD:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv508882CNV Insertion20534489
    dgv4417n71CNV Loss21882294
    nsv875744CNV Loss21882294


    Human Gene Mutation Database (HGMD): CRYGD

    Locus Specific Mutation Databases (LSDB): CRYGD
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CRYGD
    DNA2.0 Custom Variant and Variant Library Synthesis for CRYGD

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 123690   
    OMIM disorders: 115700  608983  601286  
    UniProtKB/Swiss-Prot: CRGD_HUMAN, P07320
  • Cataract 4, multiple types (CTRCT4) [MIM:115700]: An opacification of the crystalline lens of the eye
    that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a
    portion of the lens, and may be static or progressive. CTRCT4 includes crystalline aculeiform, congenital
    cerulean and non-nuclear polymorphic cataracts, among others. Crystalline aculeiform cataract is characterized by
    fiberglass-like or needle-like crystals projecting in different directions, through or close to the axial region
    of the lens. Non-nuclear polymorphic cataract is a partial opacity with variable location between the fetal
    nucleus of the lens and the equator. The fetal nucleus is normal. The opacities are irregular and look similar to
    a bunch of grapes and may be present simultaneously in different lens layers. Congenital cerulean cataract is
    characterized by peripheral bluish and white opacifications organized in concentric layers with occasional
    central lesions arranged radially. The opacities are observed in the superficial layers of the fetal nucleus as
    well as the adult nucleus of the lens. Involvement is usually bilateral. Visual acuity is only mildly reduced in
    childhood. In adulthood, the opacifications may progress, making lens extraction necessary. Histologically the
    lesions are described as fusiform cavities between lens fibers which contain a deeply staining granular material.
    Although the lesions may take on various colors, a dull blue is the most common appearance and is responsible for
    the designation cerulean cataract. Note=The disease is caused by mutations affecting the gene represented in this
    entry

  • 9 diseases for CRYGD:    About MalaCards
    cataract, congenital, cerulean type, 3    cataract, nonnuclear polymorphic congenital    cataract, crystalline aculeiform    cataracts, autosomal dominant
    cerulean cataract    cataract    impotence    posterior polar cataract
    blindness


    CRYGD for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for CRYGD gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    congenital cataract 91.3 6 19390652 (2), 17564961 (1), 16030500 (1), 17217786 (1) (see all 5)
    cataract 77.9 28 16030500 (4), 19633732 (2), 10521291 (2), 12676897 (2) (see all 14)
    nuclear cataract 77.1 3 19390652 (1), 17217786 (1), 18079686 (1)

    Genetic Association Database (GAD): CRYGD

    Export disorders for CRYGD gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CRYGD gene, integrated from 9 sources (see all 95):
    (articles sorted by number of sources associating them with CRYGD)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A missense mutation in the gammaD crystallin gene (CRYGD) associated with autosomal dominant 'coral-like' cataract linked to chromosome 2q. (PubMed id 15041957)1, 4, 9 Mackay D.S....Shiels A. (2004)
    2. Link between a novel human gamma-D-crystallin allele and a unique cataract phenotype explained by protein crystallography. (PubMed id 10915766)1, 2, 9 Kmoch S.... Elleder M. (2000)
    3. The gamma-crystallins and human cataracts: a puzzle made clearer. (PubMed id 10521291)1, 2, 9 Heon E.... Munier F.L. (1999)
    4. Conversion and compensatory evolution of the gamma-crystallin genes and identification of a cataractogenic mutation that reverses the sequence of the human CRYGD gene to an ancestral state. (PubMed id 17564961)1, 2, 9 Plotnikova O.V.... Rogaev E.I. (2007)
    5. Gamma-D crystallin gene (CRYGD) mutation causes autosomal dominant congenital cerulean cataracts. (PubMed id 12676897)1, 2, 9 Nandrot E.... Hilal L. (2003)
    6. Decrease in protein solubility and cataract formation caused by the Pro23 to Thr mutation in human gamma D-crystallin. (PubMed id 15709761)1, 2, 9 Pande A.... Pande J. (2005)
    7. A novel CRYGD mutation (p.Trp43Arg) causing autosomal dominant congenital cataract in a Chinese family. (PubMed id 21031598)1, 2 Wang B.... Xie L. (2011)
    8. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. High-resolution X-ray crystal structures of human gammaD crystallin (1.25 A) and the R58H mutant (1.15 A) associated with aculeiform cataract. (PubMed id 12729747)1, 2 Basak A.... Pande J. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1421 HGNC: 2411 AceView: CRYGD Ensembl:ENSG00000118231 euGenes: HUgn1421
    ECgene: CRYGD H-InvDB: CRYGD

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CRYGD Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/CRYGD

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CRYGD gene:
    Search GeneIP for patents involving CRYGD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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