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Aliases for CRYGC Gene

Aliases for CRYGC Gene

  • Crystallin, Gamma C 2 3
  • CRYG3 3 4 6
  • Gamma-Crystallin 2-1 3 4
  • Gamma-Crystallin 3 3 4
  • CTRCT2 3 6
  • CCL 3 6
  • Gamma-Crystallin C 3
  • Gamma-C-Crystallin 4

External Ids for CRYGC Gene

Previous Symbols for CRYGC Gene

  • CRYG3

Summaries for CRYGC Gene

Entrez Gene Summary for CRYGC Gene

  • This gene encodes a member of the beta/gamma-crystallin family of proteins. Crystallins constitute the major proteins of vertebrate eye lens and maintain the transparency and refractive index of the lens. This gene and several family members are present in a gene cluster on chromosome 2. Mutations in this gene have been shown to cause multiple types of cataract, including Coppock-like cataract and zonular pulverulent cataract, among others. [provided by RefSeq, Jan 2015]

GeneCards Summary for CRYGC Gene

CRYGC (Crystallin, Gamma C) is a Protein Coding gene. Diseases associated with CRYGC include cataract 2, multiple types and cataract, zonular. GO annotations related to this gene include structural constituent of eye lens. An important paralog of this gene is CRYBB3.

UniProtKB/Swiss-Prot for CRYGC Gene

  • Crystallins are the dominant structural components of the vertebrate eye lens

Gene Wiki entry for CRYGC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRYGC Gene

Genomics for CRYGC Gene

Genomic Location for CRYGC Gene

Start:
208,128,137 bp from pter
End:
208,129,830 bp from pter
Size:
1,694 bases
Orientation:
Minus strand

Genomic View for CRYGC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CRYGC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRYGC Gene

Regulatory Elements for CRYGC Gene

Proteins for CRYGC Gene

  • Protein details for CRYGC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07315-CRGC_HUMAN
    Recommended name:
    Gamma-crystallin C
    Protein Accession:
    P07315
    Secondary Accessions:
    • Q53R50

    Protein attributes for CRYGC Gene

    Size:
    174 amino acids
    Molecular mass:
    20879 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for CRYGC Gene

neXtProt entry for CRYGC Gene

Proteomics data for CRYGC Gene at MOPED

Post-translational modifications for CRYGC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CRYGC Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CRYGC Gene

Domains for CRYGC Gene

Protein Domains for CRYGC Gene

Suggested Antigen Peptide Sequences for CRYGC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P07315

UniProtKB/Swiss-Prot:

CRGC_HUMAN
Domain:
  • Has a two-domain beta-structure, folded into four very similar Greek key motifs:
    • P07315
  • Contains 4 beta/gamma crystallin Greek key domains.:
    • P07315
Family:
  • Belongs to the beta/gamma-crystallin family.:
    • P07315
genes like me logo Genes that share domains with CRYGC: view

No data available for Gene Families for CRYGC Gene

Function for CRYGC Gene

Molecular function for CRYGC Gene

GENATLAS Biochemistry: crystallin,gamma polypeptide C
UniProtKB/Swiss-Prot Function: Crystallins are the dominant structural components of the vertebrate eye lens

Gene Ontology (GO) - Molecular Function for CRYGC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005212 structural constituent of eye lens NAS 12507494
GO:0005515 protein binding IPI 11700327
genes like me logo Genes that share ontologies with CRYGC: view

Phenotypes for CRYGC Gene

MGI mutant phenotypes for CRYGC:
inferred from 3 alleles
genes like me logo Genes that share phenotypes with CRYGC: view

miRNA for CRYGC Gene

miRTarBase miRNAs that target CRYGC

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CRYGC Gene

Localization for CRYGC Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CRYGC Gene COMPARTMENTS Subcellular localization image for CRYGC gene
Compartment Confidence
nucleus 5
extracellular 2
cytosol 1

Gene Ontology (GO) - Cellular Components for CRYGC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 16303126
GO:0005737 cytoplasm IDA 16303126
genes like me logo Genes that share ontologies with CRYGC: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CRYGC Gene

Pathways for CRYGC Gene

SuperPathways for CRYGC Gene

No Data Available

Gene Ontology (GO) - Biological Process for CRYGC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001654 eye development --
GO:0007601 visual perception IMP 12011157
GO:0043010 camera-type eye development IEA --
genes like me logo Genes that share ontologies with CRYGC: view

No data available for Pathways by source for CRYGC Gene

Compounds for CRYGC Gene

(1) Novoseek inferred chemical compound relationships for CRYGC Gene

Compound -log(P) Hits PubMed IDs
sephadex 69.9 1
genes like me logo Genes that share compounds with CRYGC: view

Transcripts for CRYGC Gene

mRNA/cDNA for CRYGC Gene

(4) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(21) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CRYGC Gene

Crystallin, gamma C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CRYGC Gene

No ASD Table

Relevant External Links for CRYGC Gene

GeneLoc Exon Structure for
CRYGC
ECgene alternative splicing isoforms for
CRYGC

Expression for CRYGC Gene

mRNA expression in normal human tissues for CRYGC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CRYGC Gene

This gene is overexpressed in Testis (47.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CRYGC Gene

SOURCE GeneReport for Unigene cluster for CRYGC Gene Hs.72910

genes like me logo Genes that share expressions with CRYGC: view

No data available for mRNA Expression by UniProt/SwissProt for CRYGC Gene

Orthologs for CRYGC Gene

This gene was present in the common ancestor of chordates.

Orthologs for CRYGC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CRYGC 35
  • 99.43 (n)
  • 99.43 (a)
CRYGC 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CRYGC 35
  • 86.97 (n)
  • 86.21 (a)
CRYGC 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CRYGC 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Crygc 35
  • 82.95 (n)
  • 85.06 (a)
Crygc 16
Crygc 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 74 (a)
ManyToMany
-- 36
  • 68 (a)
ManyToMany
-- 36
  • 73 (a)
ManyToMany
-- 36
  • 72 (a)
ManyToMany
-- 36
  • 73 (a)
ManyToMany
-- 36
  • 71 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 70 (a)
ManyToMany
-- 36
  • 68 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Crygc 35
  • 85.44 (n)
  • 85.63 (a)
zebrafish
(Danio rerio)
Actinopterygii crygmx 36
  • 48 (a)
ManyToMany
si:dkey-57a22.15 35
  • 63.97 (n)
  • 60.12 (a)
Species with no ortholog for CRYGC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CRYGC Gene

ENSEMBL:
Gene Tree for CRYGC (if available)
TreeFam:
Gene Tree for CRYGC (if available)

Paralogs for CRYGC Gene

Selected SIMAP similar genes for CRYGC Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CRYGC: view

Variants for CRYGC Gene

Sequence variations from dbSNP and Humsavar for CRYGC Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
VAR_021142 Cataract 2, multiple types (CTRCT2)
VAR_021143 -
VAR_021144 Cataract 2, multiple types (CTRCT2)
VAR_038432 -
VAR_067212 Cataract 2, multiple types (CTRCT2)

Structural Variations from Database of Genomic Variants (DGV) for CRYGC Gene

Variant ID Type Subtype PubMed ID
nsv875744 CNV Loss 21882294
dgv4417n71 CNV Loss 21882294
nsv875747 CNV Loss 21882294
nsv875748 CNV Gain 21882294

Relevant External Links for CRYGC Gene

HapMap Linkage Disequilibrium report
CRYGC
Human Gene Mutation Database (HGMD)
CRYGC
Locus Specific Mutation Databases (LSDB)
CRYGC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRYGC Gene

Disorders for CRYGC Gene

(1) OMIM Diseases for CRYGC Gene (123680)

UniProtKB/Swiss-Prot

CRGC_HUMAN
  • Cataract 2, multiple types (CTRCT2) [MIM:604307]: An opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. CTRCT2 includes Coppock-like cataract, among others. Coppock-like cataract is a congenital pulverulent disk-like opacity involving the embryonic nucleus with many tiny white dots in the lamellar portion of the lens. It is usually bilateral and dominantly inherited. In some cases, CTRCT2 is associated with microcornea without any other systemic anomaly or dysmorphism. Microcornea is defined by a corneal diameter inferior to 10 mm in both meridians in an otherwise normal eye. {ECO:0000269 PubMed:10521291, ECO:0000269 PubMed:10914683, ECO:0000269 PubMed:12011157, ECO:0000269 PubMed:22052681, ECO:0000269 PubMed:22876111}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for CRYGC Gene

(1) Novoseek inferred disease relationships for CRYGC Gene

Disease -log(P) Hits PubMed IDs
cataract 63.6 2

Relevant External Links for CRYGC

Genetic Association Database (GAD)
CRYGC
genes like me logo Genes that share disorders with CRYGC: view

Publications for CRYGC Gene

  1. A 5-base insertion in the gammaC-crystallin gene is associated with autosomal dominant variable zonular pulverulent cataract. (PMID: 10914683) Ren Z. … Hejtmancik J.F. (Hum. Genet. 2000) 3 4 48
  2. Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies. (PMID: 18839057) Lesch K.P. … Jacob C. (J Neural Transm 2008) 3 48
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. A novel mutation impairing the tertiary structure and stability of gammaC-crystallin (CRYGC) leads to cataract formation in humans and zebrafish lens. (PMID: 22052681) Li X.Q. … Ma X. (Hum. Mutat. 2012) 3 4
  5. A nonsense mutation of CRYGC associated with autosomal dominant congenital nuclear cataracts and microcornea in a Chinese pedigree. (PMID: 22876111) Guo Y. … Zhu S. (Mol. Vis. 2012) 3 4

Products for CRYGC Gene

Sources for CRYGC Gene

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