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Aliases for CRYGC Gene

Aliases for CRYGC Gene

  • Crystallin Gamma C 2 3 5
  • Gamma-Crystallin 2-1 3 4
  • Crystallin, Gamma C 2 3
  • Gamma-Crystallin 3 3 4
  • CRYG3 3 4
  • Gamma-C-Crystallin 4
  • CTRCT2 3
  • CCL 3

External Ids for CRYGC Gene

Previous HGNC Symbols for CRYGC Gene

  • CRYG3

Previous GeneCards Identifiers for CRYGC Gene

  • GC02M207159
  • GC02M207717
  • GC02M208956
  • GC02M209195
  • GC02M208818
  • GC02M208701
  • GC02M208992
  • GC02M200841

Summaries for CRYGC Gene

Entrez Gene Summary for CRYGC Gene

  • This gene encodes a member of the beta/gamma-crystallin family of proteins. Crystallins constitute the major proteins of vertebrate eye lens and maintain the transparency and refractive index of the lens. This gene and several family members are present in a gene cluster on chromosome 2. Mutations in this gene have been shown to cause multiple types of cataract, including Coppock-like cataract and zonular pulverulent cataract, among others. [provided by RefSeq, Jan 2015]

GeneCards Summary for CRYGC Gene

CRYGC (Crystallin Gamma C) is a Protein Coding gene. Diseases associated with CRYGC include Cataract 2, Multiple Types and Pulverulent Cataract. GO annotations related to this gene include structural constituent of eye lens. An important paralog of this gene is CRYBB3.

UniProtKB/Swiss-Prot for CRYGC Gene

  • Crystallins are the dominant structural components of the vertebrate eye lens.

Gene Wiki entry for CRYGC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRYGC Gene

Genomics for CRYGC Gene

Regulatory Elements for CRYGC Gene

Enhancers for CRYGC Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CRYGC on UCSC Golden Path with GeneCards custom track

Genomic Location for CRYGC Gene

208,128,137 bp from pter
208,139,738 bp from pter
11,602 bases
Minus strand

Genomic View for CRYGC Gene

Genes around CRYGC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRYGC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRYGC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRYGC Gene

Proteins for CRYGC Gene

  • Protein details for CRYGC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Gamma-crystallin C
    Protein Accession:
    Secondary Accessions:
    • Q53R50

    Protein attributes for CRYGC Gene

    174 amino acids
    Molecular mass:
    20879 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for CRYGC Gene

neXtProt entry for CRYGC Gene

Proteomics data for CRYGC Gene at MOPED

Post-translational modifications for CRYGC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CRYGC Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CRYGC Gene

Domains & Families for CRYGC Gene

Protein Domains for CRYGC Gene

Suggested Antigen Peptide Sequences for CRYGC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Has a two-domain beta-structure, folded into four very similar Greek key motifs.
  • Belongs to the beta/gamma-crystallin family.
  • Has a two-domain beta-structure, folded into four very similar Greek key motifs.
  • Contains 4 beta/gamma crystallin Greek key domains.
  • Belongs to the beta/gamma-crystallin family.
genes like me logo Genes that share domains with CRYGC: view

No data available for Gene Families for CRYGC Gene

Function for CRYGC Gene

Molecular function for CRYGC Gene

GENATLAS Biochemistry:
crystallin,gamma polypeptide C
UniProtKB/Swiss-Prot Function:
Crystallins are the dominant structural components of the vertebrate eye lens.

Gene Ontology (GO) - Molecular Function for CRYGC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005212 structural constituent of eye lens NAS 12507494
genes like me logo Genes that share ontologies with CRYGC: view

Phenotypes for CRYGC Gene

genes like me logo Genes that share phenotypes with CRYGC: view

Human Phenotype Ontology for CRYGC Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

miRNA for CRYGC Gene

miRTarBase miRNAs that target CRYGC

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for CRYGC Gene

Localization for CRYGC Gene

Subcellular locations from

Jensen Localization Image for CRYGC Gene COMPARTMENTS Subcellular localization image for CRYGC gene
Compartment Confidence
nucleus 5
extracellular 2
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CRYGC Gene

Pathways & Interactions for CRYGC Gene

SuperPathways for CRYGC Gene

No Data Available

Gene Ontology (GO) - Biological Process for CRYGC Gene


No data available for Pathways by source and SIGNOR curated interactions for CRYGC Gene

Drugs & Compounds for CRYGC Gene

(1) Additional Compounds for CRYGC Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CRYGC: view

Transcripts for CRYGC Gene

mRNA/cDNA for CRYGC Gene

(4) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(21) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CRYGC Gene

Crystallin, gamma C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CRYGC Gene

No ASD Table

Relevant External Links for CRYGC Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CRYGC Gene

mRNA expression in normal human tissues for CRYGC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CRYGC Gene

This gene is overexpressed in Testis (x47.0).

Protein differential expression in normal tissues from HIPED for CRYGC Gene

This gene is overexpressed in Vitreous humor (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CRYGC Gene

SOURCE GeneReport for Unigene cluster for CRYGC Gene Hs.72910

genes like me logo Genes that share expression patterns with CRYGC: view

Protein tissue co-expression partners for CRYGC Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for CRYGC Gene

Orthologs for CRYGC Gene

This gene was present in the common ancestor of chordates.

Orthologs for CRYGC Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CRYGC 35
  • 86.97 (n)
  • 86.21 (a)
  • 86 (a)
(Mus musculus)
Mammalia Crygc 35
  • 82.95 (n)
  • 85.06 (a)
Crygc 16
Crygc 36
  • 85 (a)
(Pan troglodytes)
Mammalia CRYGC 35
  • 99.43 (n)
  • 99.43 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Crygc 35
  • 85.44 (n)
  • 85.63 (a)
(Canis familiaris)
Mammalia CRYGC 36
  • 87 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 74 (a)
-- 36
  • 68 (a)
-- 36
  • 73 (a)
-- 36
  • 72 (a)
-- 36
  • 73 (a)
-- 36
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 70 (a)
-- 36
  • 68 (a)
(Danio rerio)
Actinopterygii si:dkey-57a22.15 35
  • 63.97 (n)
  • 60.12 (a)
crygmx 36
  • 48 (a)
Species with no ortholog for CRYGC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CRYGC Gene

Gene Tree for CRYGC (if available)
Gene Tree for CRYGC (if available)

Paralogs for CRYGC Gene

(16) SIMAP similar genes for CRYGC Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CRYGC: view

Variants for CRYGC Gene

Sequence variations from dbSNP and Humsavar for CRYGC Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_021142 Cataract 2, multiple types (CTRCT2)
VAR_021143 -
VAR_021144 Cataract 2, multiple types (CTRCT2)
VAR_038432 -
VAR_067212 Cataract 2, multiple types (CTRCT2)

Structural Variations from Database of Genomic Variants (DGV) for CRYGC Gene

Variant ID Type Subtype PubMed ID
nsv875744 CNV Loss 21882294
dgv4417n71 CNV Loss 21882294
nsv875747 CNV Loss 21882294
nsv875748 CNV Gain 21882294

Variation tolerance for CRYGC Gene

Residual Variation Intolerance Score: 72.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.69; 46.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CRYGC Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRYGC Gene

Disorders for CRYGC Gene

MalaCards: The human disease database

(8) MalaCards diseases for CRYGC Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
cataract 2, multiple types
  • cataract 2, multiple types, with or without microcornea
pulverulent cataract
  • cataract, coppock-like
early-onset lamellar cataract
cataract microcornea syndrome
  • microcornea cataract syndrome
early-onset nuclear cataract
- elite association - COSMIC cancer census association via MalaCards
Search CRYGC in MalaCards View complete list of genes associated with diseases


  • Cataract 2, multiple types (CTRCT2) [MIM:604307]: An opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. CTRCT2 includes Coppock-like cataract, among others. Coppock-like cataract is a congenital pulverulent disk-like opacity involving the embryonic nucleus with many tiny white dots in the lamellar portion of the lens. It is usually bilateral and dominantly inherited. In some cases, CTRCT2 is associated with microcornea without any other systemic anomaly or dysmorphism. Microcornea is defined by a corneal diameter inferior to 10 mm in both meridians in an otherwise normal eye. {ECO:0000269 PubMed:10521291, ECO:0000269 PubMed:10914683, ECO:0000269 PubMed:12011157, ECO:0000269 PubMed:22052681, ECO:0000269 PubMed:22876111}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for CRYGC

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CRYGC: view

No data available for Genatlas for CRYGC Gene

Publications for CRYGC Gene

  1. A 5-base insertion in the gammaC-crystallin gene is associated with autosomal dominant variable zonular pulverulent cataract. (PMID: 10914683) Ren Z. … Hejtmancik J.F. (Hum. Genet. 2000) 3 4 48 67
  2. Mutation analysis of CRYAA, CRYGC, and CRYGD associated with autosomal dominant congenital cataract in Brazilian families. (PMID: 19390652) Santana A. … Barbosa de Melo M. (Mol. Vis. 2009) 3 23
  3. Lenticular chaperones suppress the aggregation of the cataract-causing mutant T5P gamma C-crystallin. (PMID: 16303126) Pigaga V. … Quinlan R.A. (Exp. Cell Res. 2006) 3 23
  4. Congenital Cataract-Causing Mutation G129C in I^C-Crystallin Promotes the Accumulation of Two Distinct Unfolding Intermediates That Form Highly Toxic Aggregates. (PMID: 26165230) Xi Y.B. … Yan Y.B. (J. Mol. Biol. 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for CRYGC Gene

Sources for CRYGC Gene