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CRYGB Gene

protein-coding   GIFtS: 51
GCID: GC02M209007

Crystallin, Gamma B

(Previous names: crystallin, gamma 1-2)
(Previous symbol: CRYG2)
  See CRYGB-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Crystallin, Gamma B1 2     Gamma-Crystallin B2
CRYG21 2 3 5     Gamma-B-crystallin3
Crystallin, Gamma 1-21 2     Gamma-Crystallin 1-23
CTRCT392 5     

External Ids:    HGNC: 24091   Entrez Gene: 14192   Ensembl: ENSG000001821877   OMIM: 1236705   UniProtKB: P073163   

Export aliases for CRYGB gene to outside databases

Previous GC identifers: GC02M207175 GC02M207718 GC02M208971 GC02M209209 GC02M208832 GC02M208715 GC02M200855


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CRYGB Gene:
Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class
constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the
lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then
retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into
alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta
families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four
homologous motifs, a connecting peptide, and N- and C-terminal extensions. Gamma-crystallins are a homogeneous
group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions.
They are differentially regulated after early development. Four gamma-crystallin genes (gamma-A through gamma-D)
and three pseudogenes (gamma-E, gamma-F, gamma-G) are tandemly organized in a genomic segment as a gene cluster.
Whether due to aging or mutations in specific genes, gamma-crystallins have been involved in cataract formation.
(provided by RefSeq, Jul 2008)

GeneCards Summary for CRYGB Gene:
CRYGB (crystallin, gamma B) is a protein-coding gene. Diseases associated with CRYGB include cataract 39, multiple types, autosomal dominant, and skin atrophy. GO annotations related to this gene include structural constituent of eye lens. An important paralog of this gene is CRYBB3.

UniProtKB/Swiss-Prot: CRGB_HUMAN, P07316
Function: Crystallins are the dominant structural components of the vertebrate eye lens

Gene Wiki entry for CRYGB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the CRYGB gene promoter:
         AREB6   SRF   HEN1   PPAR-gamma1   SRF (504 AA)   Olf-1   c-Myb   PPAR-gamma2   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCRYGB promoter sequence
   Search Chromatin IP Primers for CRYGB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CRYGB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q34   Ensembl cytogenetic band:  2q34   HGNC cytogenetic band: 2q34

CRYGB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRYGB gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M209007:  view genomic region     (about GC identifiers)

Start:
209,007,297 bp from pter      End:
209,010,892 bp from pter
Size:
3,596 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CRGB_HUMAN, P07316 (See protein sequence)
Recommended Name: Gamma-crystallin B  
Size: 175 amino acids; 20908 Da
Subunit: Monomer (By similarity)
Selected PDB 3D structures from and Proteopedia for CRYGB (see all 9):
1LEU (3D)        1MYV (3D)        1MYX (3D)        1MYY (3D)        1MZ1 (3D)        1MZ2 (3D)    
Secondary accessions: Q17RB5 Q53ST2

Explore the universe of human proteins at neXtProt for CRYGB: NX_P07316

Explore proteomics data for CRYGB at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CRYGB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005201.2  
    ENSEMBL proteins: 
     ENSP00000260988  

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    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online proteins for CRYGB (7 products) 

     
    antibodies-online peptides for CRYGB

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    antibodies-online kits for CRYGB (11 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR001064 Beta/gamma_crystallin
     IPR011024 G_crystallin-rel

    Graphical View of Domain Structure for InterPro Entry P07316

    ProtoNet protein and cluster: P07316

    2 Blocks protein domains:
    IPB001064 Beta and gamma crystallin
    IPB011024 Gamma-crystallin related


    UniProtKB/Swiss-Prot: CRGB_HUMAN, P07316
    Domain: Has a two-domain beta-structure, folded into four very similar Greek key motifs
    Similarity: Belongs to the beta/gamma-crystallin family
    Similarity: Contains 4 beta/gamma crystallin 'Greek key' domains


    Find genes that share domains with CRYGB           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CRGB_HUMAN, P07316
    Function: Crystallins are the dominant structural components of the vertebrate eye lens

         Genatlas biochemistry entry for CRYGB:
    crystallin,gamma polypeptide B,9kDa

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005212structural constituent of eye lens NAS12507494
         
    Find genes that share ontologies with CRYGB           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for CRYGB:
     Increased HPV18 LCR reporter a  Increased gamma-H2AX phosphory 

         1 MGI mutant phenotype (inferred from 3 alleles(MGI details for Crygb):
     vision/eye 

    Find genes that share phenotypes with CRYGB           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CRYGB

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular2
    nucleus2
    cytosol1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with CRYGB           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CRYGB
    Interactions:

        Search GeneGlobe Interaction Network for CRYGB

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for CRYGB (ENSP000002609884) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYH3ENSP000002262094STRING: ENSP00000226209
    NEURL2ENSP000003615964STRING: ENSP00000361596
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001654eye development ----
    GO:0002088lens development in camera-type eye ----
    GO:0007601visual perception NAS12507494
    GO:0070307lens fiber cell development ----
    GO:0070309lens fiber cell morphogenesis IEA--

    Find genes that share ontologies with CRYGB           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CRYGB (CRGB)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CRYGB gene: 
    NM_005210.3  

    Unigene Cluster for CRYGB:

    Crystallin, gamma B
    Hs.248102  [show with all ESTs]
    Unigene Representative Sequence: NM_005210
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000260988(uc002vcp.4)
    miRNA
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    Additional mRNA sequence: 

    BC074944.2 BC074945.2 BC117384.1 BC117388.1 

    2 DOTS entries:

    DT.91741235  DT.97824327 

    8 AceView cDNA sequences:

    BF726411 BC074944 BC074945 BM666147 NM_005210 BM712241 BM711059 BM705957 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CRYGB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATTTGTACT
    CRYGB Expression
    About this image


    CRYGB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Limb (Muscoskeletal System)
             Limb Muscle Progenitor Cells Forelimb Myotome
     
     Skeletal Muscle (Muscoskeletal System)
             Limb Muscle Progenitor Cells Forelimb Myotome
    CRYGB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CRYGB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.248102
        Custom PCR Arrays for CRYGB
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRYGB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CRYGB gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Crygb1 , 5 crystallin, gamma B1, 5 87.43(n)1
    82.86(a)1
      1 (32.82 cM)5
    129651  NM_144761.21  NP_658906.11 
     650802285 
    African clawed frog
    (Xenopus laevis)
    Amphibia crygb-prov2 crystallin, gamma B 79.38(n)    BC053775.1 
    zebrafish
    (Danio rerio)
    Actinopterygii crygs31 crystallin, gamma S3 61.49(n)
    59.77(a)
      550617  NM_001012390.1  NP_001012390.1 


    ENSEMBL Gene Tree for CRYGB (if available)
    TreeFam Gene Tree for CRYGB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CRYGB gene
    CRYBB32  CRYBA42  CRYBA12  CRYBB22  CRYGD2  CRYGA2  CRYBB12  CRYGC2  
    CRYBA22  CRYGN2  CRYGS2  
    15 SIMAP similar genes for CRYGB using alignment to 1 protein entry:     CRGB_HUMAN:
    CRYGC    CRYGD    CRYGA    CRYGS    DKFZp434A0627    CRYGN
    CRYBB3    CRYBA4    CRYBA1    CRYBB2    CRYBB1    AIM1
    AIM1L    DKFZp434L1713    CRYBA2

    Find genes that share paralogs with CRYGB           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CRYGB (see all 204)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1436391451,2
    --208395291(+) AGTGAG/TAGGAA 1 -- int10--------
    rs1163794581,2
    C,F--208395292(+) GTGAGA/GGGAAA 1 -- int11Minor allele frequency- G:0.03WA 118
    rs1476964411,2
    --208395360(+) TATTTC/GTTTGT 1 -- int10--------
    rs1878275381,2
    --208395368(+) TGTTTA/GTGGAG 1 -- int10--------
    rs1914546521,2
    --208395449(+) ATAGGA/GATAAC 1 -- int10--------
    rs7962861,2
    C,F,O,H--208395469(+) TAACTT/AGGAGG 1 -- int140Minor allele frequency- A:0.24NA EA MN NS WA 4702
    rs2005729621,2
    --208395469(+) TAACT-/TGGAGGTG 1 -- int10--------
    rs1830662161,2
    C--208395501(+) ACCACC/TGTAGC 1 -- int10--------
    rs1877835831,2
    --208395552(+) GTCCAA/GGTGAA 1 -- int10--------
    rs1919512981,2
    --208395607(+) GCTGGA/TAATAA 1 -- int10--------

    HapMap Linkage Disequilibrium report for CRYGB (209007297 - 209010892 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CRYGB:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2721407CNV Deletion23290073
    nsv834517CNV Loss17160897
    nsv875747CNV Loss21882294
    nsv875748CNV Gain21882294

    Human Gene Mutation Database (HGMD): CRYGB
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CRYGB
    DNA2.0 Custom Variant and Variant Library Synthesis for CRYGB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 123670   
    OMIM disorders: 615188  
    UniProtKB/Swiss-Prot: CRGB_HUMAN, P07316
  • Cataract 39, multiple types (CTRCT39) [MIM:615188]: An opacification of the crystalline lens of the eye
    that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a
    portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an
    opacity, the greater the impact on visual function. CTRCT39 includes lamellar, anterior polar, and complete
    cataracts. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 7 diseases for CRYGB:    
    About MalaCards
    cataract 39, multiple types, autosomal dominant    skin atrophy    cataract 20, multiple types    cerulean cataract
    congenital aphakia    cataract 23    cataract

    1 disease from the University of Copenhagen DISEASES database for CRYGB:
    Congenital aphakia

    Find genes that share disorders with CRYGB           About GenesLikeMe

    1 Novoseek inferred disease relationship for CRYGB gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cataract 51.4 1 12162443 (1)

    Genetic Association Database (GAD): CRYGB
    Human Genome Epidemiology (HuGE) Navigator: CRYGB (2 documents)

    Export disorders for CRYGB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CRYGB gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with CRYGB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of possible sites for posttranslational modifications in human gamma crystallins: effect of glycation on the structure of human gamma-B-crystallin as analyzed by molecular modeling. (PubMed id 14517968)1, 2, 9 Salim A.... Zaidi Z.H. (Proteins 2003)
    2. Novel crystallin gamma B mutations in a Kuwaiti family with autosomal dominant congenital cataracts reveal genetic and clinical heterogeneity. (PubMed id 23288985)1, 2 AlFadhli S....Alkuraya F. (Mol. Vis. 2012)
    3. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    4. Analysis of single nucleotide polymorphisms of CRYGA and CRYGB genes in control population of western Indian origin. (PubMed id 19384013)1, 4 Kapur S....Rajkumar S. (Indian J Ophthalmol 2009)
    5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Gamma-D crystallin gene (CRYGD) mutation causes autosomal dominant congenital cerulean cataracts. (PubMed id 12676897)1, 2 Nandrot E.... Hilal L. (J. Med. Genet. 2003)
    8. Homology models of human gamma-crystallins: structural study of the extensive charge network in gamma-crystallins. (PubMed id 12507494)1, 2 Salim A. and Zaidi Z.H. (Biochem. Biophys. Res. Commun. 2003)
    9. Novel mutations in the gamma-crystallin genes cause autosomal dominant congenital cataracts. (PubMed id 12011157)1, 2 Santhiya S.T.... Graw J. (J. Med. Genet. 2002)
    10. Nucleotide sequence of the rat gamma-crystallin gene region and comparison with an orthologous human region. (PubMed id 2777080)1, 2 den Dunnen J.T....Schoenmakers J.G.G. (Gene 1989)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
    Disorders
    Free Text  

      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1419 HGNC: 2409 AceView: CRYGB Ensembl:ENSG00000182187 euGenes: HUgn1419
    ECgene: CRYGB H-InvDB: CRYGB

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CRYGB Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CRYGB gene:
    Search GeneIP for patents involving CRYGB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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