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Aliases for CRYGB Gene

Aliases for CRYGB Gene

  • Crystallin, Gamma B 2 3
  • CRYG2 3 4 6
  • Crystallin, Gamma 1-2 2 3
  • CTRCT39 3 6
  • Gamma-Crystallin 1-2 4
  • Gamma-Crystallin B 3
  • Gamma-B-Crystallin 4

External Ids for CRYGB Gene

Previous Symbols for CRYGB Gene

  • CRYG2

Summaries for CRYGB Gene

Entrez Gene Summary for CRYGB Gene

  • Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Gamma-crystallins are a homogeneous group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions. They are differentially regulated after early development. Four gamma-crystallin genes (gamma-A through gamma-D) and three pseudogenes (gamma-E, gamma-F, gamma-G) are tandemly organized in a genomic segment as a gene cluster. Whether due to aging or mutations in specific genes, gamma-crystallins have been involved in cataract formation. [provided by RefSeq, Jul 2008]

GeneCards Summary for CRYGB Gene

CRYGB (Crystallin, Gamma B) is a Protein Coding gene. Diseases associated with CRYGB include cataract 39, multiple types, autosomal dominant and congenital aphakia. GO annotations related to this gene include structural constituent of eye lens. An important paralog of this gene is CRYGC.

UniProtKB/Swiss-Prot for CRYGB Gene

  • Crystallins are the dominant structural components of the vertebrate eye lens

Gene Wiki entry for CRYGB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRYGB Gene

Genomics for CRYGB Gene

Genomic Location for CRYGB Gene

Start:
208,142,573 bp from pter
End:
208,146,168 bp from pter
Size:
3,596 bases
Orientation:
Minus strand

Genomic View for CRYGB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CRYGB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRYGB Gene

Regulatory Elements for CRYGB Gene

Proteins for CRYGB Gene

  • Protein details for CRYGB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07316-CRGB_HUMAN
    Recommended name:
    Gamma-crystallin B
    Protein Accession:
    P07316
    Secondary Accessions:
    • Q17RB5
    • Q53ST2

    Protein attributes for CRYGB Gene

    Size:
    175 amino acids
    Molecular mass:
    20908 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for CRYGB Gene

neXtProt entry for CRYGB Gene

Proteomics data for CRYGB Gene at MOPED

Post-translational modifications for CRYGB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CRYGB Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CRYGB Gene

Domains for CRYGB Gene

Protein Domains for CRYGB Gene

UniProtKB/Swiss-Prot:

CRGB_HUMAN
Domain:
  • Has a two-domain beta-structure, folded into four very similar Greek key motifs:
    • P07316
  • Contains 4 beta/gamma crystallin Greek key domains.:
    • P07316
Family:
  • Belongs to the beta/gamma-crystallin family.:
    • P07316
genes like me logo Genes that share domains with CRYGB: view

No data available for Gene Families for CRYGB Gene

Function for CRYGB Gene

Molecular function for CRYGB Gene

GENATLAS Biochemistry: crystallin,gamma polypeptide B,9kDa
UniProtKB/Swiss-Prot Function: Crystallins are the dominant structural components of the vertebrate eye lens

Gene Ontology (GO) - Molecular Function for CRYGB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005212 structural constituent of eye lens NAS 12507494
genes like me logo Genes that share ontologies with CRYGB: view

Phenotypes for CRYGB Gene

genes like me logo Genes that share phenotypes with CRYGB: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CRYGB Gene

Localization for CRYGB Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CRYGB Gene COMPARTMENTS Subcellular localization image for CRYGB gene
Compartment Confidence
extracellular 2
nucleus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for CRYGB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CRYGB: view

Pathways for CRYGB Gene

SuperPathways for CRYGB Gene

No Data Available

Interacting Proteins for CRYGB Gene

Gene Ontology (GO) - Biological Process for CRYGB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001654 eye development --
GO:0002088 lens development in camera-type eye --
GO:0007601 visual perception NAS 12507494
GO:0070307 lens fiber cell development --
GO:0070309 lens fiber cell morphogenesis IEA --
genes like me logo Genes that share ontologies with CRYGB: view

No data available for Pathways by source for CRYGB Gene

Transcripts for CRYGB Gene

mRNA/cDNA for CRYGB Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CRYGB Gene

Crystallin, gamma B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CRYGB Gene

No ASD Table

Relevant External Links for CRYGB Gene

GeneLoc Exon Structure for
CRYGB
ECgene alternative splicing isoforms for
CRYGB

Expression for CRYGB Gene

mRNA expression in normal human tissues for CRYGB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CRYGB Gene

This gene is overexpressed in Testis (20.6), Brain - Spinal cord (cervical c-1) (7.6), and Brain - Substantia nigra (5.8).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CRYGB Gene

SOURCE GeneReport for Unigene cluster for CRYGB Gene Hs.248102

genes like me logo Genes that share expressions with CRYGB: view

Orthologs for CRYGB Gene

This gene was present in the common ancestor of chordates.

Orthologs for CRYGB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CRYGB 36
  • 98.67 (n)
  • 97.71 (a)
CRYGB 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CRYGB 36
  • 85.9 (n)
  • 84 (a)
CRYGB 37
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CRYGB 36
  • 87.24 (n)
  • 84 (a)
CRYGB 37
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Crygb 36
  • 87.43 (n)
  • 82.86 (a)
Crygb 16
Crygb 37
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 56 (a)
ManyToMany
-- 37
  • 74 (a)
ManyToMany
-- 37
  • 69 (a)
ManyToMany
-- 37
  • 80 (a)
ManyToMany
-- 37
  • 74 (a)
ManyToMany
-- 37
  • 75 (a)
ManyToMany
-- 37
  • 74 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 66 (a)
ManyToMany
-- 37
  • 65 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Crygb 36
  • 87.81 (n)
  • 82.86 (a)
African clawed frog
(Xenopus laevis)
Amphibia crygb-prov 36
zebrafish
(Danio rerio)
Actinopterygii crygmxl1 37
  • 65 (a)
ManyToMany
crygmxl2 37
  • 58 (a)
ManyToMany
crygs3 36
  • 61.49 (n)
  • 59.77 (a)
Species with no ortholog for CRYGB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CRYGB Gene

ENSEMBL:
Gene Tree for CRYGB (if available)
TreeFam:
Gene Tree for CRYGB (if available)

Paralogs for CRYGB Gene

Selected SIMAP similar genes for CRYGB Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CRYGB: view

Variants for CRYGB Gene

Sequence variations from dbSNP and Humsavar for CRYGB Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
VAR_021140 -
VAR_021141 -
VAR_029517 -

Structural Variations from Database of Genomic Variants (DGV) for CRYGB Gene

Variant ID Type Subtype PubMed ID
nsv875747 CNV Loss 21882294
nsv875748 CNV Gain 21882294
nsv834517 CNV Loss 17160897
esv2721407 CNV Deletion 23290073

Relevant External Links for CRYGB Gene

HapMap Linkage Disequilibrium report
CRYGB
Human Gene Mutation Database (HGMD)
CRYGB

Disorders for CRYGB Gene

(1) OMIM Diseases for CRYGB Gene (123670)

UniProtKB/Swiss-Prot

CRGB_HUMAN
  • Cataract 39, multiple types (CTRCT39) [MIM:615188]: An opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function. CTRCT39 includes lamellar, anterior polar, and complete cataracts. {ECO:0000269 PubMed:23288985}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for CRYGB Gene

(1) Novoseek inferred disease relationships for CRYGB Gene

Disease -log(P) Hits PubMed IDs
cataract 51.4 1

Relevant External Links for CRYGB

Genetic Association Database (GAD)
CRYGB
Human Genome Epidemiology (HuGE) Navigator
CRYGB
genes like me logo Genes that share disorders with CRYGB: view

Publications for CRYGB Gene

  1. Prediction of possible sites for posttranslational modifications in human gamma crystallins: effect of glycation on the structure of human gamma-B-crystallin as analyzed by molecular modeling. (PMID: 14517968) Salim A. … Zaidi Z.H. (Proteins 2003) 3 4 23
  2. Affilin-novel binding molecules based on human gamma-B-crystallin, an all beta-sheet protein. (PMID: 17628592) Ebersbach H. … Fiedler U. (J. Mol. Biol. 2007) 4 23
  3. Two human gamma-crystallin genes are linked and riddled with Alu- repeats. (PMID: 4065573) den Dunnen J.T. … Schoenmakers J.G.G. (Gene 1985) 3 4
  4. Nucleotide sequence of the rat gamma-crystallin gene region and comparison with an orthologous human region. (PMID: 2777080) den Dunnen J.T. … Schoenmakers J.G.G. (Gene 1989) 3 4
  5. Novel mutations in the gamma-crystallin genes cause autosomal dominant congenital cataracts. (PMID: 12011157) Santhiya S.T. … Graw J. (J. Med. Genet. 2002) 3 4

Products for CRYGB Gene

Sources for CRYGB Gene

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