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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CRYGA Gene

protein-coding GIFtS: 45
GCID: GC02M209025

crystallin, gamma A

(Previous symbol: CRYG1)

Explore 2 diseases affiliated with
CRYGA via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Crystallin, Gamma A¹ ²		Gamma-Crystallin 5² ³
CRYG1¹ ² ³ ⁵		Crystallin, Gamma 1²
CRY-G-A¹		Gamma-Crystallin A²
CRYG5¹ ²		Gamma-A-Crystallin¹

External Ids:	HGNC: 2408¹	Entrez Gene: 1418²	Ensembl: ENSG00000168582⁷	OMIM: 123660⁵	UniProtKB: P11844³

Export aliases for CRYGA gene to outside databases

Previous GC identifers: GC02M207194 GC02M207750 GC02M208989 GC02M209228 GC02M208850 GC02M208733 GC02M200873

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CRYGA:

Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the

major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens

central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout

life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma

families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided

into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting

peptide, and N- and C-terminal extensions. Gamma-crystallins are a homogeneous group of highly symmetrical, monomeric

proteins typically lacking connecting peptides and terminal extensions. They are differentially regulated after early

development. Four gamma-crystallin genes (gamma-A through gamma-D) and three pseudogenes (gamma-E, gamma-F, gamma-G)

are tandemly organized in a genomic segment as a gene cluster. Whether due to aging or mutations in specific genes,

gamma-crystallins have been involved in cataract formation. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CRGA_HUMAN, P11844

Function: Crystallins are the dominant structural components of the vertebrate eye lens

Gene Wiki entry for CRYGA

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_005403.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CRYGA gene promoter:
SRF NCX/Ncx SRF (504 AA) HTF MIF-1 LCR-F1 AREB6 PPAR-gamma1 c-Myb PPAR-gamma2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CRYGA promoter sequence

Search SABiosciences Chromatin IP Primers for CRYGA

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CRYGA

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q34 Ensembl cytogenetic band: 2q34 HGNC cytogenetic band: 2q34

CRYGA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRYGA gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M209025: view genomic region (about GC identifiers)

Start:	209,025,464 bp from pter	End:	209,028,300 bp from pter
Size:	2,837 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CRGA_HUMAN, P11844 (See protein sequence)

Recommended Name: Gamma-crystallin A

Size: 174 amino acids; 20877 Da

Subunit: Monomer (By similarity)

1 PDB 3D structure from and Proteopedia for CRYGA:

1LER (3D)

Secondary accessions: Q53ST5

Explore the universe of human proteins at neXtProt for CRYGA: NX_P11844

CRYGA Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_055432.2

ENSEMBL proteins:

ENSP00000302105

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--

CRYGA for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CRYGA for domains About GeneDecksing

2 InterPro domains/families:

IPR001064 Beta/gamma_crystallin

IPR011024 G_crystallin-rel

Graphical View of Domain Structure for InterPro Entry P11844

ProtoNet protein and cluster: P11844

2 Blocks protein families:

IPB001064 Beta and gamma crystallin

IPB011024 Gamma-crystallin related

UniProtKB/Swiss-Prot: CRGA_HUMAN, P11844

Domain: Has a two-domain beta-structure, folded into four very similar Greek key motifs

Similarity: Belongs to the beta/gamma-crystallin family

Similarity: Contains 4 beta/gamma crystallin 'Greek key' domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CRGA_HUMAN, P11844

Function: Crystallins are the dominant structural components of the vertebrate eye lens

Genatlas biochemistry entry for CRYGA:

crystallin,gamma polypeptide A

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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005212	structural constituent of eye lens	NAS	12507494

CRYGA for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for CRYGA:

Decreased Salmonella enterica

Animal Models:
1 MGI mutant phenotype (inferred from 2 alleles) (MGI details for Cryga):

vision/eye

CRYGA for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CRYGA

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001654	eye development	--	--
GO:0002088	lens development in camera-type eye	IEA	--
GO:0007601	visual perception	NAS	3670288

CRYGA for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CRYGA
Search CenterWatch for drugs/clinical trials and news about CRYGA / CRGA

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for CRYGA gene:

NM_014617.3

Unigene Cluster for CRYGA:

Crystallin, gamma A

Hs.122566 [show with all ESTs]

Unigene Representative Sequence: BC114456

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000304502(uc002vcq.4)

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Additional cDNA sequence:

BC114456.1 EF426311.1

2 DOTS entries:

DT.307153 DT.120998479

12 AceView cDNA sequences:

BM698524 BM698997 BM667614 BM710792 NM_014617 BM710815 BX281946 BM667439

AI052518 BG207174 AA404481 AA780079

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CRYGA expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

CRYGA expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Lens

Eye

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CRYGA Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CRYGA

SOURCE GeneReport for Unigene cluster: Hs.122566

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CRYGA gene from 1/7 species (see all 7) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
zebrafish (Danio rerio)	Actinopterygii	si:dkey-57a22.15¹	si:dkey-57a22.15	68.22(n) 60.47(a)		795575 NM_001123311.1 NP_001116783.1

ENSEMBL Gene Tree for CRYGA (if available)
TreeFam Gene Tree for CRYGA (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CRYGA gene

CRYBB3² CRYGB² CRYBA4² CRYBA1² CRYBB2² CRYGD² CRYBB1² CRYGC²

CRYGN² CRYBA2² CRYGS²

14 SIMAP similar genes for CRYGA using alignment to 2 protein entries: CRGA_HUMAN (see all proteins):

CRYGB CRYGD CRYGC CRYGS DKFZp434A0627 CRYGN

CRYBA2 CRYBA1 CRYBB3 CRYBB1 CRYBA4 CRYBB2

AIM1L AIM1

CRYGA for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs185068064^1,2		--	209025018(+)	`TCTACC/TAGTAA`	1	--	int¹		0	--	--	--	--
rs6729051^1,2	C,F,A,H,	--	209025027(+)	`AAGTAG/TCAGAG`	1	--	int¹		23		NS EA NA WA	2446
rs188983472^1,2		--	209025102(+)	`CTTCTC/TCACGT`	1	--	int¹		0	--	--	--	--
rs2441349^1,2	C,A,H,	--	209025193(+)	`CGGGCA/GGATCA`	1	--	int¹		0	--	--	--	--
rs2441350^1,2	C,H,	--	209025226(+)	`CAGCCT/CGACCA`	1	--	int¹		7		NA WA	14
rs13430564^1,2	C,	--	209025300(+)	`taatcC/Acagtt`	1	--	int¹		1		NA	2
rs180910430^1,2		--	209025331(+)	`AGGATG/TGATTG`	1	--	int¹		0	--	--	--	--
rs186315607^1,2		--	209025373(+)	`GATAGC/TGCCAT`	1	--	int¹		0	--	--	--	--
rs201789574^1,2	F	--	209025490(+)	`ATTTAT/CTATGT`	1	--	ut3¹		1		EU	1323
rs189542184^1,2	C,	--	209025502(+)	`TCTATA/GGGGAT`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CRYGA (209025464 - 209028300 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CRYGA: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CRYGA for disorders           About GeneDecksing

OMIM gene information: 123660    OMIM disorders: --

2 diseases for CRYGA:    About MalaCards

cataract congenital cataracts

1 Novoseek disease relationship for CRYGA gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cataract	54.6	1	12646746 (1)

Human Genome Epidemiology (HuGE) Navigator: CRYGA (1 document)

Export disorders for CRYGA gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CRYGA gene, integrated from 9 sources (see all 21):
(articles sorted by number of sources associating them with CRYGA)

Utopia: connect your pdf to the dynamic
world of online information

Homology models of human gamma-crystallins: structural study of the extensive charge network in gamma-crystallins. (PubMed id 12507494)^{1, 2} Salim A. and Zaidi Z.H. (2003)
Novel mutations in the gamma-crystallin genes cause autosomal dominant congenital cataracts. (PubMed id 12011157)^{1, 2} Santhiya S.T.... Graw J. (2002)
Gamma-crystallins of the human eye lens: expression analysis of five members of the gene family. (PubMed id 3670288)^{1, 2} Meakin S.O.... Breitman M.L. (1987)
Analysis of single nucleotide polymorphisms of CRYGA and CRYGB genes in control population of western Indian origin. (PubMed id 19384013)¹ Kapur S....Rajkumar S. (2009)
Lens aging: effects of crystallins. (PubMed id 19463898)¹ Sharma K.K. and Santhoshkumar P. (2009)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)² Hillier L.W....Wilson R.K. (2005)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Structure of the crystallins. (PubMed id 10627816)¹ Slingsby C. and Clout N.J. (1999)
The crystallins: genes, proteins and diseases. (PubMed id 9426193)¹ Graw J. (1997)
Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)¹ Bonaldo M.F.... Soares M.B. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 1418	HGNC: 2408	AceView: CRYGA	Ensembl:ENSG00000168582	euGenes: HUgn1418
ECgene: CRYGA	H-InvDB: CRYGA

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CRYGA	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CRYGA gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CRYGA gene:
Search GeneIP for patents involving CRYGA

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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	OriGene Purified Protein for CRYGA		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for CRYGA		OriGene Custom Protein Services for CRYGA
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CRYGA
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CRYGA
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CRYGA
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CRYGA
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRYGA
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CRYGA

	GenScript Custom Purified and Recombinant Proteins Services for CRYGA		GenScript cDNA clones with any tag delivered in your preferred vector for CRYGA
	GenScript Custom Assay Services for CRYGA		GenScript Custom Superior Antibodies Services for CRYGA
	GenScript Custom overexpressing Cell Line Services for CRYGA		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in CRYGA promoter
	Search Chromatin IP Primers for CRYGA
	RT² qPCR Primer Assay in human, mouse / rat CRYGA
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	Browse Sino Biological Proteins and Antibodies
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Biologicals
	Novus Tissue Slides

	Search for Antibodies for CRYGA at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for CRYGA
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Browse ProSpec Recombinant Proteins

Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn

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Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CRYGA

	Browse SwitchGear 3'UTR luciferase reporter plasmids for CRYGA
	SwitchGear Promoter luciferase reporter plasmids for CRYGA

ThermoFisher Antibodies for CRYGA

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRYGA

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes CRYGA gene at Home site.

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CRYGA Gene

crystallin, gamma A

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CRYGA Gene

crystallin, gamma A

Aliasesfor CRYGA gene

Summariesfor CRYGA gene

Genomic Viewsfor CRYGA gene

Proteinsfor CRYGA gene

Protein Domains /Familiesfor CRYGA gene

Functionfor CRYGA gene

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Specialized Databases showing CRYGA gene

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for CRYGA gene

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for CRYGA gene

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for CRYGA gene

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for CRYGA gene

Pathways & Interactions
for CRYGA gene

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for CRYGA gene

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for CRYGA gene

Expression
for CRYGA gene

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for CRYGA gene

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for CRYGA gene

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for CRYGA gene

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for CRYGA gene

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for CRYGA gene

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