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Aliases for CRYGA Gene

Aliases for CRYGA Gene

  • Crystallin Gamma A 2 3 5
  • Crystallin, Gamma A 2 3
  • Gamma-Crystallin 5 3 4
  • CRYG1 3 4
  • Crystallin, Gamma 1 3
  • Gamma Crystallin 5 2
  • Gamma-A-Crystallin 4
  • CRY-G-A 3
  • CRYG5 3

External Ids for CRYGA Gene

Previous HGNC Symbols for CRYGA Gene

  • CRYG1

Previous GeneCards Identifiers for CRYGA Gene

  • GC02M207194
  • GC02M207750
  • GC02M208989
  • GC02M209228
  • GC02M208850
  • GC02M208733
  • GC02M209025
  • GC02M200873

Summaries for CRYGA Gene

Entrez Gene Summary for CRYGA Gene

  • Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Gamma-crystallins are a homogeneous group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions. They are differentially regulated after early development. Four gamma-crystallin genes (gamma-A through gamma-D) and three pseudogenes (gamma-E, gamma-F, gamma-G) are tandemly organized in a genomic segment as a gene cluster. Whether due to aging or mutations in specific genes, gamma-crystallins have been involved in cataract formation. [provided by RefSeq, Jul 2008]

GeneCards Summary for CRYGA Gene

CRYGA (Crystallin Gamma A) is a Protein Coding gene. Diseases associated with CRYGA include Cataract and Lens Disease. GO annotations related to this gene include structural constituent of eye lens. An important paralog of this gene is CRYGC.

UniProtKB/Swiss-Prot for CRYGA Gene

  • Crystallins are the dominant structural components of the vertebrate eye lens.

Gene Wiki entry for CRYGA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRYGA Gene

Genomics for CRYGA Gene

Regulatory Elements for CRYGA Gene

Enhancers for CRYGA Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CRYGA on UCSC Golden Path with GeneCards custom track

Genomic Location for CRYGA Gene

208,160,740 bp from pter
208,163,576 bp from pter
2,837 bases
Minus strand

Genomic View for CRYGA Gene

Genes around CRYGA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRYGA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRYGA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRYGA Gene

Proteins for CRYGA Gene

  • Protein details for CRYGA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Gamma-crystallin A
    Protein Accession:
    Secondary Accessions:
    • Q53ST5

    Protein attributes for CRYGA Gene

    174 amino acids
    Molecular mass:
    20877 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for CRYGA Gene

neXtProt entry for CRYGA Gene

Proteomics data for CRYGA Gene at MOPED

Post-translational modifications for CRYGA Gene

No Post-translational modifications

Other Protein References for CRYGA Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CRYGA Gene

Domains & Families for CRYGA Gene

Protein Domains for CRYGA Gene

Suggested Antigen Peptide Sequences for CRYGA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Has a two-domain beta-structure, folded into four very similar Greek key motifs.
  • Belongs to the beta/gamma-crystallin family.
  • Has a two-domain beta-structure, folded into four very similar Greek key motifs.
  • Contains 4 beta/gamma crystallin Greek key domains.
  • Belongs to the beta/gamma-crystallin family.
genes like me logo Genes that share domains with CRYGA: view

No data available for Gene Families for CRYGA Gene

Function for CRYGA Gene

Molecular function for CRYGA Gene

GENATLAS Biochemistry:
crystallin,gamma polypeptide A
UniProtKB/Swiss-Prot Function:
Crystallins are the dominant structural components of the vertebrate eye lens.
genes like me logo Genes that share phenotypes with CRYGA: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CRYGA Gene

Localization for CRYGA Gene

Subcellular locations from

Jensen Localization Image for CRYGA Gene COMPARTMENTS Subcellular localization image for CRYGA gene
Compartment Confidence
extracellular 3
cytosol 1
mitochondrion 1
nucleus 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CRYGA Gene

Pathways & Interactions for CRYGA Gene

SuperPathways for CRYGA Gene

No Data Available

Interacting Proteins for CRYGA Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000302105 for CRYGA Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for CRYGA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007601 visual perception NAS 3670288
genes like me logo Genes that share ontologies with CRYGA: view

No data available for Pathways by source and SIGNOR curated interactions for CRYGA Gene

Drugs & Compounds for CRYGA Gene

No Compound Related Data Available

Transcripts for CRYGA Gene

mRNA/cDNA for CRYGA Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CRYGA Gene

Crystallin, gamma A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CRYGA Gene

No ASD Table

Relevant External Links for CRYGA Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CRYGA Gene

mRNA expression in normal human tissues for CRYGA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CRYGA Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x7.4), Brain - Cortex (x7.2), Brain - Nucleus accumbens (basal ganglia) (x6.4), Brain - Hippocampus (x5.3), Brain - Amygdala (x5.2), Brain - Hypothalamus (x4.5), Brain - Anterior cingulate cortex (BA24) (x4.3), and Brain - Putamen (basal ganglia) (x4.1).

Protein differential expression in normal tissues from HIPED for CRYGA Gene

This gene is overexpressed in Vitreous humor (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CRYGA Gene

SOURCE GeneReport for Unigene cluster for CRYGA Gene Hs.122566

genes like me logo Genes that share expression patterns with CRYGA: view

Protein tissue co-expression partners for CRYGA Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for CRYGA Gene

Orthologs for CRYGA Gene

This gene was present in the common ancestor of chordates.

Orthologs for CRYGA Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CRYGA 35
  • 82.57 (n)
  • 80.46 (a)
-- 36
  • 83 (a)
(Canis familiaris)
Mammalia CRYGA 35
  • 83.72 (n)
  • 81.03 (a)
  • 81 (a)
(Mus musculus)
Mammalia Cryga 35
  • 83.52 (n)
  • 84.48 (a)
Cryga 16
Cryga 36
  • 84 (a)
(Pan troglodytes)
Mammalia CRYGA 35
  • 99.81 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Cryga 35
  • 83.52 (n)
  • 83.91 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 71 (a)
-- 36
  • 69 (a)
-- 36
  • 69 (a)
-- 36
  • 70 (a)
-- 36
  • 71 (a)
-- 36
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 66 (a)
-- 36
  • 63 (a)
(Danio rerio)
Actinopterygii crygmx 35
  • 62.02 (n)
  • 52.33 (a)
si:dkey-57a22.14 36
  • 49 (a)
Species with no ortholog for CRYGA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CRYGA Gene

Gene Tree for CRYGA (if available)
Gene Tree for CRYGA (if available)

Paralogs for CRYGA Gene

(14) SIMAP similar genes for CRYGA Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CRYGA: view

Variants for CRYGA Gene

Sequence variations from dbSNP and Humsavar for CRYGA Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_021139 -
rs796278 -- 208,162,700(+) TGGGC(A/T)TGGTG intron-variant
rs796279 -- 208,163,147(+) CAGGA(A/G)TTGAT intron-variant
rs796280 -- 208,163,467(+) GGTGA(C/T)AGTAG intron-variant
rs2885601 -- 208,164,500(-) ATGCT(A/T)GAAGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CRYGA Gene

Variant ID Type Subtype PubMed ID
nsv875747 CNV Loss 21882294
nsv875748 CNV Gain 21882294
nsv834517 CNV Loss 17160897
dgv4418n71 CNV Loss 21882294

Variation tolerance for CRYGA Gene

Residual Variation Intolerance Score: 85.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.96; 19.83% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CRYGA Gene

Disorders for CRYGA Gene

MalaCards: The human disease database

(2) MalaCards diseases for CRYGA Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
lens disease
  • lens diseases
- elite association - COSMIC cancer census association via MalaCards
Search CRYGA in MalaCards View complete list of genes associated with diseases

Relevant External Links for CRYGA

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CRYGA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CRYGA Gene

Publications for CRYGA Gene

  1. Analysis of single nucleotide polymorphisms of CRYGA and CRYGB genes in control population of western Indian origin. (PMID: 19384013) Kapur S. … Rajkumar S. (Indian J Ophthalmol 2009) 3 48 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. A novel human CRYGD mutation in a juvenile autosomal dominant cataract. (PMID: 20508808) Roshan M. … Satyamoorthy K. (Mol. Vis. 2010) 23
  4. Lens aging: effects of crystallins. (PMID: 19463898) Sharma K.K. … Santhoshkumar P. (Biochim. Biophys. Acta 2009) 3
  5. Homology models of human gamma-crystallins: structural study of the extensive charge network in gamma-crystallins. (PMID: 12507494) Salim A. … Zaidi Z.H. (Biochem. Biophys. Res. Commun. 2003) 3

Products for CRYGA Gene

Sources for CRYGA Gene