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Aliases for CRYBG3 Gene

Aliases for CRYBG3 Gene

  • Beta-Gamma Crystallin Domain Containing 3 2 3
  • Beta/Gamma Crystallin Domain-Containing Protein 3 3 4
  • VlAKAP 3 4
  • Very Large A-Kinase Anchor Protein 3
  • DKFZp667G2110 3

External Ids for CRYBG3 Gene

Summaries for CRYBG3 Gene

GeneCards Summary for CRYBG3 Gene

CRYBG3 (Beta-Gamma Crystallin Domain Containing 3) is a Protein Coding gene. An important paralog of this gene is AIM1L.

UniProtKB/Swiss-Prot for CRYBG3 Gene

  • Isoform vlAKAP: Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRYBG3 Gene

Genomics for CRYBG3 Gene

Genomic Location for CRYBG3 Gene

Start:
97,821,934 bp from pter
End:
97,944,986 bp from pter
Size:
123,053 bases
Orientation:
Plus strand

Genomic View for CRYBG3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CRYBG3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRYBG3 Gene

Regulatory Elements for CRYBG3 Gene

Proteins for CRYBG3 Gene

  • Protein details for CRYBG3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q68DQ2-CRBG3_HUMAN
    Recommended name:
    Very large A-kinase anchor protein
    Protein Accession:
    Q68DQ2
    Secondary Accessions:
    • B4DLE8
    • F6VHI2
    • Q4G0V8
    • Q7Z4R9
    • Q86VD0
    • Q8N262
    • Q8N7F1
    • Q8NDQ8

    Protein attributes for CRYBG3 Gene

    Size:
    2970 amino acids
    Molecular mass:
    330633 Da
    Quaternary structure:
    • Isoform vlAKAP binds to dimeric RII-alpha regulatory subunit of PKA (PRKAR2A/PRKAR2B).
    SequenceCaution:
    • Sequence=AAH36247.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAP97687.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC03608.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAH18168.1; Type=Frameshift; Positions=14; Evidence={ECO:0000305};

    Alternative splice isoforms for CRYBG3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CRYBG3 Gene

Proteomics data for CRYBG3 Gene at MOPED

Post-translational modifications for CRYBG3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CRYBG3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CRYBG3 Gene

Domains for CRYBG3 Gene

UniProtKB/Swiss-Prot:

CRBG3_HUMAN
Domain:
  • Contains 9 beta/gamma crystallin Greek key domains.:
    • Q68DQ2
  • Contains 1 ricin B-type lectin domain.:
    • Q68DQ2
Family:
  • Belongs to the beta/gamma-crystallin family.:
    • Q68DQ2
genes like me logo Genes that share domains with CRYBG3: view

No data available for Gene Families for CRYBG3 Gene

Function for CRYBG3 Gene

Molecular function for CRYBG3 Gene

UniProtKB/Swiss-Prot Function: Isoform vlAKAP: Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA).

Gene Ontology (GO) - Molecular Function for CRYBG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with CRYBG3: view

miRNA for CRYBG3 Gene

miRTarBase miRNAs that target CRYBG3

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CRYBG3 Gene

Localization for CRYBG3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CRYBG3 Gene COMPARTMENTS Subcellular localization image for CRYBG3 gene
Compartment Confidence
nucleus 3
cytosol 1

No data available for Gene Ontology (GO) - Cellular Components for CRYBG3 Gene

Pathways for CRYBG3 Gene

SuperPathways for CRYBG3 Gene

No Data Available

Interacting Proteins for CRYBG3 Gene

Selected Interacting proteins: Q68DQ2-CRBG3_HUMAN for CRYBG3 Gene via I2D

Gene Ontology (GO) - Biological Process for CRYBG3 Gene

None

No data available for Pathways by source for CRYBG3 Gene

Transcripts for CRYBG3 Gene

mRNA/cDNA for CRYBG3 Gene

(2) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CRYBG3 Gene

Beta-gamma crystallin domain containing 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CRYBG3 Gene

No ASD Table

Relevant External Links for CRYBG3 Gene

GeneLoc Exon Structure for
CRYBG3
ECgene alternative splicing isoforms for
CRYBG3

Expression for CRYBG3 Gene

mRNA expression in normal human tissues for CRYBG3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for CRYBG3 Gene

SOURCE GeneReport for Unigene cluster for CRYBG3 Gene Hs.733378

genes like me logo Genes that share expressions with CRYBG3: view

Orthologs for CRYBG3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CRYBG3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CRYBG3 36
  • 99.29 (n)
  • 98.59 (a)
CRYBG3 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CRYBG3 37
  • 86 (a)
OneToOne
LOC516526 36
  • 80.71 (n)
  • 70.94 (a)
dog
(Canis familiaris)
Mammalia CRYBG3 36
  • 82.93 (n)
  • 73.28 (a)
mouse
(Mus musculus)
Mammalia Crybg3 36
  • 79.44 (n)
  • 76.89 (a)
Crybg3 16
Crybg3 37
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 76 (a)
OneToMany
-- 37
  • 63 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia CRYBG3 37
  • 26 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Crybg3 36
  • 75.59 (n)
  • 64.3 (a)
chicken
(Gallus gallus)
Aves CRYBG3 37
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CRYBG3 37
  • 54 (a)
OneToOne
Species with no ortholog for CRYBG3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CRYBG3 Gene

ENSEMBL:
Gene Tree for CRYBG3 (if available)
TreeFam:
Gene Tree for CRYBG3 (if available)

Paralogs for CRYBG3 Gene

Paralogs for CRYBG3 Gene

Selected SIMAP similar genes for CRYBG3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CRYBG3: view

Variants for CRYBG3 Gene

Sequence variations from dbSNP and Humsavar for CRYBG3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs699300 -- 97,847,729(-) GATTT(C/T)ATATA intron-variant
rs699301 -- 97,925,808(+) AGGTA(C/T)ATGGT intron-variant
rs699302 -- 97,932,910(-) AGCAG(G/T)AATCA intron-variant
rs699303 -- 97,933,372(-) AGTCC(G/T)GCCAA intron-variant
rs766567 -- 97,920,102(+) ATGCT(A/G)CACAA intron-variant

Relevant External Links for CRYBG3 Gene

HapMap Linkage Disequilibrium report
CRYBG3
Human Gene Mutation Database (HGMD)
CRYBG3

No data available for Structural Variations from Database of Genomic Variants (DGV) for CRYBG3 Gene

Disorders for CRYBG3 Gene

Relevant External Links for CRYBG3

Genetic Association Database (GAD)
CRYBG3
Human Genome Epidemiology (HuGE) Navigator
CRYBG3
genes like me logo Genes that share disorders with CRYBG3: view

No data available for UniProtKB/Swiss-Prot for CRYBG3 Gene

Publications for CRYBG3 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  4. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny D.M. … Gibbs R.A. (Nature 2006) 4
  5. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4

Products for CRYBG3 Gene

Sources for CRYBG3 Gene

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