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Aliases for CRYBG3 Gene

Aliases for CRYBG3 Gene

  • Beta-Gamma Crystallin Domain Containing 3 2 3
  • Beta/Gamma Crystallin Domain-Containing Protein 3 3 4
  • VlAKAP 3 4
  • DKFZp667G2110 3

External Ids for CRYBG3 Gene

Previous GeneCards Identifiers for CRYBG3 Gene

  • GC03P099078
  • GC03P097595
  • GC03P094910

Summaries for CRYBG3 Gene

GeneCards Summary for CRYBG3 Gene

CRYBG3 (Beta-Gamma Crystallin Domain Containing 3) is a Protein Coding gene. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is AIM1L.

UniProtKB/Swiss-Prot for CRYBG3 Gene

  • Isoform vlAKAP: Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRYBG3 Gene

Genomics for CRYBG3 Gene

Regulatory Elements for CRYBG3 Gene

Genomic Location for CRYBG3 Gene

97,821,937 bp from pter
97,944,986 bp from pter
123,050 bases
Plus strand

Genomic View for CRYBG3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CRYBG3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRYBG3 Gene

Proteins for CRYBG3 Gene

  • Protein details for CRYBG3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Very large A-kinase anchor protein
    Protein Accession:
    Secondary Accessions:
    • B4DLE8
    • F6VHI2
    • Q4G0V8
    • Q7Z4R9
    • Q86VD0
    • Q8N262
    • Q8N7F1
    • Q8NDQ8

    Protein attributes for CRYBG3 Gene

    2970 amino acids
    Molecular mass:
    330633 Da
    Quaternary structure:
    • Isoform vlAKAP binds to dimeric RII-alpha regulatory subunit of PKA (PRKAR2A/PRKAR2B).
    • Sequence=AAH36247.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAP97687.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC03608.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAH18168.1; Type=Frameshift; Positions=14; Evidence={ECO:0000305};

    Alternative splice isoforms for CRYBG3 Gene


neXtProt entry for CRYBG3 Gene

Proteomics data for CRYBG3 Gene at MOPED

Post-translational modifications for CRYBG3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CRYBG3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CRYBG3 Gene

Domains & Families for CRYBG3 Gene

Suggested Antigen Peptide Sequences for CRYBG3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 9 beta/gamma crystallin Greek key domains.
  • Belongs to the beta/gamma-crystallin family.
  • Contains 9 beta/gamma crystallin Greek key domains.
  • Contains 1 ricin B-type lectin domain.
  • Belongs to the beta/gamma-crystallin family.
genes like me logo Genes that share domains with CRYBG3: view

No data available for Gene Families for CRYBG3 Gene

Function for CRYBG3 Gene

Molecular function for CRYBG3 Gene

UniProtKB/Swiss-Prot Function:
Isoform vlAKAP: Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA).

Gene Ontology (GO) - Molecular Function for CRYBG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with CRYBG3: view

Phenotypes for CRYBG3 Gene

GenomeRNAi human phenotypes for CRYBG3:
genes like me logo Genes that share phenotypes with CRYBG3: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CRYBG3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for CRYBG3 Gene

Localization for CRYBG3 Gene

Subcellular locations from

Jensen Localization Image for CRYBG3 Gene COMPARTMENTS Subcellular localization image for CRYBG3 gene
Compartment Confidence
cytosol 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CRYBG3 Gene

Pathways & Interactions for CRYBG3 Gene

SuperPathways for CRYBG3 Gene

No Data Available

Interacting Proteins for CRYBG3 Gene

Selected Interacting proteins: Q68DQ2-CRBG3_HUMAN for CRYBG3 Gene via I2D

Gene Ontology (GO) - Biological Process for CRYBG3 Gene


No data available for Pathways by source and SIGNOR curated interactions for CRYBG3 Gene

Drugs & Compounds for CRYBG3 Gene

No Compound Related Data Available

Transcripts for CRYBG3 Gene

mRNA/cDNA for CRYBG3 Gene

(2) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CRYBG3 Gene

Beta-gamma crystallin domain containing 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CRYBG3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CRYBG3 Gene

No ASD Table

Relevant External Links for CRYBG3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CRYBG3 Gene

mRNA expression in normal human tissues for CRYBG3 Gene

Protein differential expression in normal tissues from HIPED for CRYBG3 Gene

This gene is overexpressed in Heart (22.8), Ovary (19.5), and Testis (16.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for CRYBG3 Gene

SOURCE GeneReport for Unigene cluster for CRYBG3 Gene Hs.733378

genes like me logo Genes that share expression patterns with CRYBG3: view

Protein tissue co-expression partners for CRYBG3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CRYBG3 Gene

Orthologs for CRYBG3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CRYBG3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC516526 35
  • 80.71 (n)
  • 70.94 (a)
  • 86 (a)
(Canis familiaris)
Mammalia CRYBG3 35
  • 82.93 (n)
  • 73.28 (a)
(Mus musculus)
Mammalia Crybg3 35
  • 79.44 (n)
  • 76.89 (a)
Crybg3 16
Crybg3 36
  • 67 (a)
(Pan troglodytes)
Mammalia CRYBG3 35
  • 99.29 (n)
  • 98.59 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Crybg3 35
  • 75.59 (n)
  • 64.3 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 76 (a)
-- 36
  • 63 (a)
(Ornithorhynchus anatinus)
Mammalia CRYBG3 36
  • 26 (a)
(Gallus gallus)
Aves CRYBG3 36
  • 65 (a)
(Anolis carolinensis)
Reptilia CRYBG3 36
  • 54 (a)
Species with no ortholog for CRYBG3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CRYBG3 Gene

Gene Tree for CRYBG3 (if available)
Gene Tree for CRYBG3 (if available)

Paralogs for CRYBG3 Gene

Paralogs for CRYBG3 Gene

(11) SIMAP similar genes for CRYBG3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CRYBG3: view

Variants for CRYBG3 Gene

Sequence variations from dbSNP and Humsavar for CRYBG3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs699301 -- 97,925,808(+) AGGTA(C/T)ATGGT intron-variant
rs699302 -- 97,932,910(-) AGCAG(G/T)AATCA intron-variant
rs699303 -- 97,933,372(-) AGTCC(G/T)GCCAA intron-variant
rs766567 -- 97,920,102(+) ATGCT(A/G)CACAA intron-variant
rs831868 -- 97,931,560(-) ccagg(A/G)aaaga intron-variant

Variation tolerance for CRYBG3 Gene

Gene Damage Index Score: 11.52; 92.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CRYBG3 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CRYBG3 Gene

Disorders for CRYBG3 Gene

Relevant External Links for CRYBG3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CRYBG3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CRYBG3 Gene

Publications for CRYBG3 Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  2. A systematic evaluation of protein kinase A-A-Kinase anchoring protein interaction motifs. (PMID: 25097019) Burgers P.P. … Scholten A. (Biochemistry 2015) 67
  3. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 67
  5. A quantitative atlas of mitotic phosphorylation. (PMID: 18669648) Dephoure N. … Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008) 67

Products for CRYBG3 Gene

Sources for CRYBG3 Gene

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