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Aliases for CRYBG3 Gene

Aliases for CRYBG3 Gene

  • Crystallin Beta-Gamma Domain Containing 3 2 3 5
  • Beta/Gamma Crystallin Domain-Containing Protein 3 3 4
  • Beta-Gamma Crystallin Domain Containing 3 2 3
  • VlAKAP 3 4
  • Very Large A-Kinase Anchor Protein 3
  • DKFZp667G2110 3

External Ids for CRYBG3 Gene

Previous GeneCards Identifiers for CRYBG3 Gene

  • GC03P099078
  • GC03P097595
  • GC03P094910

Summaries for CRYBG3 Gene

GeneCards Summary for CRYBG3 Gene

CRYBG3 (Crystallin Beta-Gamma Domain Containing 3) is a Protein Coding gene. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is CRYBG1.

UniProtKB/Swiss-Prot for CRYBG3 Gene

  • Isoform vlAKAP: Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRYBG3 Gene

Genomics for CRYBG3 Gene

Regulatory Elements for CRYBG3 Gene

Enhancers for CRYBG3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G098038 1.1 Ensembl ENCODE 9 +217.5 217510 1.0 HDGF ATF1 MLX BRCA1 RAD21 CBX5 SCRT2 ZNF143 ZNF207 RCOR1 OR5K4 CRYBG3 GABRR3 GC03P098051
GH03G097910 1.1 Ensembl ENCODE 4.7 +89.1 89135 1.7 HDAC1 PKNOX1 ATF1 FOXA2 TBL1XR1 ARNT NFRKB TCF12 ZNF766 GATA2 RIOX2 CRYBG3 LOC105373994
GH03G097969 1 ENCODE 4.6 +149.5 149548 4.0 HDGF PKNOX1 CREB3L1 ZFP64 WRNIP1 ARID4B SIN3A DMAP1 ZNF48 YY1 RIOX2 CRYBG3 LOC105373994
GH03G097820 1.2 ENCODE dbSUPER 0.7 +0.5 543 3.1 SIN3A DMAP1 ZNF48 YY1 ZNF143 KLF7 ZNF263 SP3 REST CBX8 RIOX2 CRYBG3 LOC105373994
GH03G097871 0.8 Ensembl ENCODE 0.2 +50.4 50381 2.2 JUND JUN FOS EP300 MAFK LOC105373994 CRYBG3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CRYBG3 on UCSC Golden Path with GeneCards custom track

Promoters for CRYBG3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000155309 563 2601 SIN3A DMAP1 ZNF48 YY1 ZNF143 KLF7 ZNF263 REST CBX8 SMARCA4

Genomic Location for CRYBG3 Gene

97,821,937 bp from pter
97,944,986 bp from pter
123,050 bases
Plus strand

Genomic View for CRYBG3 Gene

Genes around CRYBG3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRYBG3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRYBG3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRYBG3 Gene

Proteins for CRYBG3 Gene

  • Protein details for CRYBG3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Very large A-kinase anchor protein
    Protein Accession:
    Secondary Accessions:
    • B4DLE8
    • F6VHI2
    • Q4G0V8
    • Q7Z4R9
    • Q86VD0
    • Q8N262
    • Q8N7F1
    • Q8NDQ8

    Protein attributes for CRYBG3 Gene

    2970 amino acids
    Molecular mass:
    330633 Da
    Quaternary structure:
    • Isoform vlAKAP binds to dimeric RII-alpha regulatory subunit of PKA (PRKAR2A/PRKAR2B).
    • Sequence=AAH36247.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAP97687.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC03608.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAH18168.1; Type=Frameshift; Positions=14; Evidence={ECO:0000305};

    Alternative splice isoforms for CRYBG3 Gene


neXtProt entry for CRYBG3 Gene

Post-translational modifications for CRYBG3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CRYBG3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CRYBG3 Gene

Domains & Families for CRYBG3 Gene

Gene Families for CRYBG3 Gene

Suggested Antigen Peptide Sequences for CRYBG3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the beta/gamma-crystallin family.
  • Belongs to the beta/gamma-crystallin family.
genes like me logo Genes that share domains with CRYBG3: view

Function for CRYBG3 Gene

Molecular function for CRYBG3 Gene

UniProtKB/Swiss-Prot Function:
Isoform vlAKAP: Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA).

Gene Ontology (GO) - Molecular Function for CRYBG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with CRYBG3: view

Phenotypes for CRYBG3 Gene

genes like me logo Genes that share phenotypes with CRYBG3: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CRYBG3 Gene

Localization for CRYBG3 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CRYBG3 gene
Compartment Confidence
nucleus 3
cytosol 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CRYBG3 Gene

Pathways & Interactions for CRYBG3 Gene

SuperPathways for CRYBG3 Gene

No Data Available

Interacting Proteins for CRYBG3 Gene

Selected Interacting proteins: Q68DQ2-CRBG3_HUMAN for CRYBG3 Gene via IID

Gene Ontology (GO) - Biological Process for CRYBG3 Gene


No data available for Pathways by source and SIGNOR curated interactions for CRYBG3 Gene

Drugs & Compounds for CRYBG3 Gene

No Compound Related Data Available

Transcripts for CRYBG3 Gene

Unigene Clusters for CRYBG3 Gene

Beta-gamma crystallin domain containing 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CRYBG3 Gene

No ASD Table

Relevant External Links for CRYBG3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CRYBG3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CRYBG3 Gene

Protein differential expression in normal tissues from HIPED for CRYBG3 Gene

This gene is overexpressed in Heart (22.8), Ovary (19.5), and Testis (16.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CRYBG3 Gene

Protein tissue co-expression partners for CRYBG3 Gene

NURSA nuclear receptor signaling pathways regulating expression of CRYBG3 Gene:


SOURCE GeneReport for Unigene cluster for CRYBG3 Gene:


Evidence on tissue expression from TISSUES for CRYBG3 Gene

  • Skin(4.3)
  • Lymph node(4.2)
  • Nervous system(4.2)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with CRYBG3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CRYBG3 Gene

Orthologs for CRYBG3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CRYBG3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CRYBG3 34 35
  • 99.29 (n)
(Bos Taurus)
Mammalia CRYBG3 35
  • 86 (a)
LOC516526 34
  • 80.71 (n)
(Canis familiaris)
Mammalia CRYBG3 34
  • 82.93 (n)
(Mus musculus)
Mammalia Crybg3 34 16 35
  • 79.44 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 76 (a)
-- 35
  • 63 (a)
(Rattus norvegicus)
Mammalia Crybg3 34
  • 75.59 (n)
(Ornithorhynchus anatinus)
Mammalia CRYBG3 35
  • 26 (a)
(Gallus gallus)
Aves CRYBG3 35
  • 65 (a)
(Anolis carolinensis)
Reptilia CRYBG3 35
  • 54 (a)
Species where no ortholog for CRYBG3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CRYBG3 Gene

Gene Tree for CRYBG3 (if available)
Gene Tree for CRYBG3 (if available)

Paralogs for CRYBG3 Gene

Paralogs for CRYBG3 Gene

(11) SIMAP similar genes for CRYBG3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CRYBG3: view

Variants for CRYBG3 Gene

Sequence variations from dbSNP and Humsavar for CRYBG3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000069027 -- 97,944,780(+) TCATT(A/T)TAAAA nc-transcript-variant, utr-variant-3-prime
rs1000086957 -- 97,842,988(+) AGTTC(A/G)CACAA intron-variant
rs1000128156 -- 97,937,374(+) GCTAC(A/C)CCACC intron-variant
rs1000136898 -- 97,890,407(+) ACTTC(A/G)GTTGT intron-variant
rs1000148450 -- 97,918,910(+) ATTGT(A/G)TCCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CRYBG3 Gene

Variant ID Type Subtype PubMed ID
esv2725668 CNV deletion 23290073
esv3597104 CNV loss 21293372
nsv1011526 CNV gain 25217958
nsv1012322 CNV gain 25217958
nsv1013060 CNV gain 25217958
nsv520553 CNV gain 19592680

Variation tolerance for CRYBG3 Gene

Gene Damage Index Score: 11.52; 92.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CRYBG3 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRYBG3 Gene

Disorders for CRYBG3 Gene

Relevant External Links for CRYBG3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CRYBG3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CRYBG3 Gene

Publications for CRYBG3 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  5. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3 64

Products for CRYBG3 Gene

Sources for CRYBG3 Gene

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