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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CRYBB2 Gene

protein-coding GIFtS: 53
GCID: GC22P025615

crystallin, beta B2

(Previous symbols: CCA2, CRYB2A, CRYB2)

Explore 14 diseases affiliated with
CRYBB2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Crystallin, Beta B2¹ ²		Beta-Crystallin Bp² ³
CRYB2¹ ² ³ ⁵		D22S665²
CRYB2A¹ ² ³		Beta-Crystallin B2²
CCA2¹ ²		Eye Lens Structural Protein²
Beta-B2 Crystallin² ³

External Ids:	HGNC: 2398¹	Entrez Gene: 1415²	Ensembl: ENSG00000244752⁷	OMIM: 123620⁵	UniProtKB: P43320³

Export aliases for CRYBB2 gene to outside databases

Previous GC identifers: GC22P022313 GC22P023940 GC22P023941 GC22P008563

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CRYBB2:

Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the

major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens

central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout

life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma

families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided

into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting

peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the

C-terminal extension (present in the basic group, none in the acidic group). Beta-crystallins form aggregates of

different sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins.

This gene, a beta basic group member, is part of a gene cluster with beta-A4, beta-B1, and beta-B3. A

chain-terminating mutation was found to cause type 2 cerulean cataracts. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CRBB2_HUMAN, P43320

Function: Crystallins are the dominant structural components of the vertebrate eye lens

Gene Wiki entry for CRYBB2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000022.10 NC_018933.1 NT_011520.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CRYBB2 gene promoter:
Zic1 Brachyury Lmo2 Zic3 E47
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CRYBB2 promoter sequence

Search SABiosciences Chromatin IP Primers for CRYBB2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CRYBB2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.23 Ensembl cytogenetic band: 22q11.23 HGNC cytogenetic band: 22q11.23

CRYBB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRYBB2 gene location

GeneLoc information about chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22P025615: view genomic region (about GC identifiers)

Start:	25,615,489 bp from pter	End:	25,627,836 bp from pter
Size:	12,348 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CRBB2_HUMAN, P43320 (See protein sequence)

Recommended Name: Beta-crystallin B2

Size: 205 amino acids; 23380 Da

Subunit: Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be

stabilized through interactions between the N-terminal arms (By similarity)

Mass spectrometry: Mass=23291; Mass_error=3; Method=Electrospray; Range=2-205; Source=PubMed:8999933;

Mass spectrometry: Mass=23289; Method=Electrospray; Range=2-205; Source=PubMed:8175657;

Mass spectrometry: Mass=23290; Method=Electrospray; Range=2-205; Source=PubMed:10930324;

1 PDB 3D structure from and Proteopedia for CRYBB2:

1YTQ (3D)

Secondary accessions: Q9UCM8

Explore the universe of human proteins at neXtProt for CRYBB2: NX_P43320

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P43320

CRYBB2 Protein expression data from MOPED and PaxDb: --

REFSEQ proteins: NP_000487.1

ENSEMBL proteins:

ENSP00000381273

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CRYBB2 for domains About GeneDecksing

2 InterPro domains/families:

IPR001064 Beta/gamma_crystallin

IPR011024 G_crystallin-rel

Graphical View of Domain Structure for InterPro Entry P43320

ProtoNet protein and cluster: P43320

2 Blocks protein families:

IPB001064 Beta and gamma crystallin

IPB011024 Gamma-crystallin related

UniProtKB/Swiss-Prot: CRBB2_HUMAN, P43320

Domain: Has a two-domain beta-structure, folded into four very similar Greek key motifs

Similarity: Belongs to the beta/gamma-crystallin family

Similarity: Contains 4 beta/gamma crystallin 'Greek key' domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CRBB2_HUMAN, P43320

Function: Crystallins are the dominant structural components of the vertebrate eye lens

Genatlas biochemistry entry for CRYBB2:

crystallin,beta polypeptide B2

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005198	structural molecule activity	NAS	8224918
GO:0005212	structural constituent of eye lens	IEA	--
GO:0042802	identical protein binding	IPI	16319073
GO:0042803	protein homodimerization activity	IEA	--

CRYBB2 for ontologies About GeneDecksing

Phenotypes:
3 GenomeRNAi human phenotypes for CRYBB2:

G0/1 arrest

Increased G1 DNA content

Synthetic lethal with imatinib

3 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Crybb2):

cellular

nervous system

vision/eye

CRYBB2 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Crybb2^tm1Itl for CRYBB2

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CRYBB2

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRYBB2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Wnt Signaling Pathway

Wnt Signaling Pathway NetPath

0.22

1 BioSystems Pathway for CRYBB2

Wnt Signaling Pathway NetPath

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CRYBB2

5/10 Interacting proteins for CRYBB2 (P43320^{1, 2, 3}) via UniProtKB, MINT, STRING, and/or I2D (see all 10)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CRYAA	P02489²^,³	MINT-14200 MINT-14199 MINT-14201 I2D: score=4
CRYAB	P02511²^,³	MINT-17764 MINT-17762 MINT-17763 I2D: score=4
CRYGC	P07315²^,³	MINT-16208 MINT-16209 MINT-16207 I2D: score=3
HSPB1	P04792²^,³	MINT-16469 I2D: score=4
CRYBA2	P53672²^,³	MINT-5162081 I2D: score=2

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007601	visual perception	IEA	--
GO:0043010	camera-type eye development	IEA	--
GO:0050896	response to stimulus	IEA	--

CRYBB2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CRYBB2
Search CenterWatch for drugs/clinical trials and news about CRYBB2 / CRBB2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CRYBB2 gene:

NM_000496.2

Unigene Cluster for CRYBB2:

Crystallin, beta B2

Hs.373074 [show with all ESTs]

Unigene Representative Sequence: NM_000496

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000398215(uc003abp.1)

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Additional cDNA sequence:

BC069535.1 CR456426.1 L10035.1

6 DOTS entries:

DT.97855900 DT.120646233 DT.120646267 DT.97855899 DT.97855898 DT.97855901

24/354 AceView cDNA sequences (see all 354):

BF727342 BM667918 BF727099 BM705786 BM705681 BU734595 BM705878 BM716449

BM705016 BM696280 BU734986 BM696538 BF726454 BM706040 BM696750 BF727088

BM705662 BF726692 BM696937 BF726391 BM705979 BM706349 BM705381 BM696875

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CRYBB2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTCCTTCCC

About this image

CRYBB2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Lens

Eye

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Genevestigator expression for CRYBB2

SOURCE GeneReport for Unigene cluster: Hs.373074

SABiosciences Custom PCR Arrays for CRYBB2

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRYBB2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CRYBB2 gene from 3/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Details
chicken (Gallus gallus)	Aves	CRYBB2¹	crystallin, beta B2	81.14(n) 82.93(a)	396088 NM_205175.3 NP_990506.2
African clawed frog (Xenopus laevis)	Amphibia	Xl.17581²	Xenopus laevis transcribed sequence with moderate similarity more	79.32(n)	BX847026.1
zebrafish (Danio rerio)	Actinopterygii	crybb2¹	crystallin, beta B2	75.45(n) 75.12(a)	553182 NM_001018128.1 NP_001018138.1

ENSEMBL Gene Tree for CRYBB2 (if available)
TreeFam Gene Tree for CRYBB2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CRYBB2 gene

CRYBB3² CRYBA4² CRYGB² CRYBA1² CRYGD² CRYGA² CRYBB1² CRYGC²

CRYGN² CRYBA2² CRYGS²

15 SIMAP similar genes for CRYBB2 using alignment to 1 protein entry: CRBB2_HUMAN:

CRYBB1 CRYBB3 CRYBA1 CRYBA4 CRYBA2 CRYGS

DKFZp434A0627 CRYBG3 CRYGB CRYGC AIM1L CRYGA

CRYGD DKFZp434L1713 AIM1

CRYBB2 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for CRYBB2
PGOHUM00000246551

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 22 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs74315489^1,2	C	pathogenic	8575253(+)	`GCTACC/TAGTAC`	2	Q *	stg¹		0	--	--	--	--
rs111615381^1,2		--	8561299(+)	`TATGCG/ATCAGG`	1	--	us2k¹		1		CSA	2
rs7284141^1,2	H	--	8561402(+)	`GAGTAA/TCAGAA`	1	--	us2k¹		4		NS EA	416
rs9620497^1,2	F,H	--	8561468(+)	`TGTGTG/TTGTAG`	1	--	us2k¹		6		NS EA WA NA	638
rs112074371^1,2	C	--	8561520(+)	`TGAGAG/AACAGG`	1	--	us2k¹		2		NA	122
rs9620498^1,2	C,F	--	8561839(+)	`gaggcG/Agagct`	1	--	us2k¹		2		NA WA	4
rs6004489^1,2		--	8561863(+)	`gatcgC/Tgccac`	1	--	us2k¹		0	--	--	--	--
rs73162239^1,2		--	8562002(+)	`CACTCC/TAGGAC`	1	--	us2k¹		0	--	--	--	--
rs7284775^1,2	C,F,H	--	8563393(+)	`AgtgaC/Gtttgg`	1	--	int¹		10		NS EA NA WA	1306
rs12161077^1,2	C,F,H	--	8563530(+)	`agtggG/Ccattg`	1	--	int¹		6		NS EA WA	494

HapMap Linkage Disequilibrium report for CRYBB2 (25615489 - 25627836 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 13 variations for CRYBB2
13 CNVs: 2270 67861 34568 90997 5357 3239 54003 79528 8903 4120 31083 53978 34657
Human Gene Mutation Database (HGMD): CRYBB2

Locus Specific Mutation Databases (LSDB): CRYBB2

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CRYBB2

DNA2.0 Custom Variant and Variant Library Synthesis for CRYBB2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CRYBB2 for disorders           About GeneDecksing

OMIM gene information: 123620
OMIM disorders: 601547  607133  604307
UniProtKB/Swiss-Prot: CRBB2_HUMAN, P43320

Defects in CRYBB2 are the cause of cataract congenital cerulean type 2 (CCA2) [MIM:601547]; also known as

congenital cataract blue dot type 2. A cerulean form of autosomal dominant congenital cataract. Cerulean cataract is

characterized by peripheral bluish and white opacifications organized in concentric layers with occasional central

lesions arranged radially. The opacities are observed in the superficial layers of the fetal nucleus as well as the

adult nucleus of the lens. Involvement is usually bilateral. Visual acuity is only mildly reduced in childhood. In

adulthood, the opacifications may progress, making lens extraction necessary. Histologically the lesions are described

as fusiform cavities between lens fibers which contain a deeply staining granular material. Although the lesions may

take on various colors, a dull blue is the most common appearance and is responsible for the designation cerulean

cataract

Defects in CRYBB2 are the cause of cataract sutural with punctate and cerulean opacities (CSPC) [MIM:607133].

A form of cataract characterized by white opacification around the anterior and posterior Y sutures, and grayish and

bluish, spindle shaped, oval punctate and cerulean opacities of various sizes arranged in lamellar form. The spots are

more concentrated towards the peripheral layers and do not delineate the embryonal or fetal nucleus. Phenotypic

variation with respect to the size and density of the sutural opacities as well as the number and position of punctate

and cerulean spots is observed among affected subjects

Defects in CRYBB2 are a cause of cataract Coppock-like (CCL) [MIM:604307]. A congenital pulverulent disk-like

opacity involving the embryonic nucleus with many tiny white dots in the lamellar portion of the lens. It is usually

bilateral and dominantly inherited

14 diseases for CRYBB2: About MalaCards

cataract, sutural, with punctate and cerulean opacities cerulean cataract cataract, coppock-like cataract

cataract, cerulean, type 2 cataracts, autosomal dominant posterior polar cataract age related macular degeneration

macular degeneration congenital cataracts senile cataract neurofibromatosis

blindness retinitis

1 disease from the University of Copenhagen DISEASES database for CRYBB2:

Senile cataract

3 Novoseek disease relationships for CRYBB2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cataract, autosomal dominant	93.9	2	11424921 (1), 17234267 (1)
congenital cataract	86.3	1	15452067 (1)
cataract	68.7	8	19321936 (1), 20450675 (1), 12567263 (1), 15452067 (1) (see all 7)

Export disorders for CRYBB2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CRYBB2 gene, integrated from 9 sources (see all 66):
(articles sorted by number of sources associating them with CRYBB2)

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Sequence of the human lens beta B2-crystallin-encoding cDNA. (PubMed id 8224918)^{1, 2, 3, 9} Chambers C. and Russell P. (1993)
Autosomal dominant cerulean cataract is associated with a chain termination mutation in the human beta-crystallin gene CRYBB2. (PubMed id 9158139)^{1, 2, 3} Litt M.... Maumenee I.H. (1997)
Post-translational modifications of water-soluble human lens crystallins from young adults. (PubMed id 8175657)^{1, 2, 9} Miesbauer L.R....Smith J.B. (1994)
A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)^{1, 2} Collins J.E.... Dunham I. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The major in vivo modifications of the human water-insoluble lens crystallins are disulfide bonds, deamidation, methionine oxidation and backbone cleavage. (PubMed id 10930324)^{1, 2} Hanson S.R.A.... Smith J.B. (2000)
Genetic heterogeneity of the Coppock-like cataract: a mutation in CRYBB2 on chromosome 22q11.2. (PubMed id 10634616)^{1, 2} Gill D.... Heon E. (2000)
The DNA sequence of human chromosome 22. (PubMed id 10591208)^{1, 2} Dunham I....O'Brien K.P. (1999)
Sequence analysis of betaA3, betaB3, and betaA4 crystallins completes the identification of the major proteins in young human lens. (PubMed id 8999933)^{1, 2} Lampi K.J....David L.L. (1997)
Amino acid sequence of human lens beta B2-crystallin. (PubMed id 8443605)^{1, 2} Miesbauer L.R.... Smith D.L. (1993)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1415	HGNC: 2398	AceView: CRYBB2	Ensembl:ENSG00000244752	euGenes: HUgn1415
ECgene: CRYBB2	H-InvDB: CRYBB2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CRYBB2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CRYBB2 gene
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crystallin, beta B2

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