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CRYBB1 Gene

protein-coding   GIFtS: 55
GCID: GC22M026995

Crystallin, Beta B1

  See CRYBB1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Crystallin, Beta B11 2
Beta-B1 Crystallin2 3
CATCN32 5
CTRCT172 5
Beta-Crystallin B12
Eye Lens Structural Protein2

External Ids:    HGNC: 23971   Entrez Gene: 14142   Ensembl: ENSG000001001227   OMIM: 6009295   UniProtKB: P536743   

Export aliases for CRYBB1 gene to outside databases

Previous GC identifers: GC22M023691 GC22M025319 GC22M009942


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CRYBB1 Gene:
Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class
constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the
lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then
retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into
alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta
families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four
homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most
heterogeneous, differ by the presence of the C-terminal extension (present in the basic group, none in the acidic
group). Beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to
form heterodimers with other beta-crystallins. This gene, a beta basic group member, undergoes extensive cleavage
at its N-terminal extension during lens maturation. It is also a member of a gene cluster with beta-A4, beta-B2,
and beta-B3. (provided by RefSeq, Jul 2008)

GeneCards Summary for CRYBB1 Gene:
CRYBB1 (crystallin, beta B1) is a protein-coding gene. Diseases associated with CRYBB1 include cataract 17, multiple types, and cataract, congenital nuclear, autosomal recessive 3. GO annotations related to this gene include structural constituent of eye lens. An important paralog of this gene is CRYBB3.

UniProtKB/Swiss-Prot: CRBB1_HUMAN, P53674
Function: Crystallins are the dominant structural components of the vertebrate eye lens

Gene Wiki entry for CRYBB1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000022.10  NC_018933.2  NT_011520.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the CRYBB1 gene promoter:
         Pax-5   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCRYBB1 promoter sequence
   Search Chromatin IP Primers for CRYBB1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CRYBB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.1   Ensembl cytogenetic band:  22q12.1   HGNC cytogenetic band: 22q12.1

CRYBB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRYBB1 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M026995:  view genomic region     (about GC identifiers)

Start:
26,995,242 bp from pter      End:
27,014,052 bp from pter
Size:
18,811 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CRBB1_HUMAN, P53674 (See protein sequence)
Recommended Name: Beta-crystallin B1  
Size: 252 amino acids; 28023 Da
Subunit: Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be
stabilized through interactions between the N-terminal arms
Mass spectrometry: Mass=27941; Mass_error=6; Method=Electrospray; Range=2-252; Source=PubMed:8626774;
1 PDB 3D structure from and Proteopedia for CRYBB1:
1OKI (3D)    

Explore the universe of human proteins at neXtProt for CRYBB1: NX_P53674

Explore proteomics data for CRYBB1 at MOPED

Post-translational modifications: 

  • Specific cleavages in the N-terminal arm occur during lens maturation and give rise to truncated forms, leading to
    impaired oligomerization and protein insolubilization1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CRYBB1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001878.1  
    ENSEMBL proteins: 
     ENSP00000215939  

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    antibodies-online proteins for CRYBB1 (22 products) 

     
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    antibodies-online kits for CRYBB1 (13 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR001064 Beta/gamma_crystallin
     IPR011024 G_crystallin-rel

    Graphical View of Domain Structure for InterPro Entry P53674

    ProtoNet protein and cluster: P53674

    2 Blocks protein domains:
    IPB001064 Beta and gamma crystallin
    IPB011024 Gamma-crystallin related


    UniProtKB/Swiss-Prot: CRBB1_HUMAN, P53674
    Domain: Has a two-domain beta-structure, folded into four very similar Greek key motifs
    Similarity: Belongs to the beta/gamma-crystallin family
    Similarity: Contains 4 beta/gamma crystallin 'Greek key' domains


    Find genes that share domains with CRYBB1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CRBB1_HUMAN, P53674
    Function: Crystallins are the dominant structural components of the vertebrate eye lens

         Genatlas biochemistry entry for CRYBB1:
    crystallin,beta polypeptide B1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005212structural constituent of eye lens IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with CRYBB1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for CRYBB1:
     Decreased nuclei size in G2M  Increased gamma-H2AX phosphory 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CRYBB1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    extracellular1
    mitochondrion1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CRYBB1
    Interactions:

        Search GeneGlobe Interaction Network for CRYBB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for CRYBB1 (P536742, 3 ENSP000002159394) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CRYBA2P536722, 3, ENSP000002957284MINT-5162066 I2D: score=2 STRING: ENSP00000295728
    CRYBA4P536732, 3, ENSP000003468054MINT-5161990 I2D: score=2 STRING: ENSP00000346805
    CRYBA1P058133, ENSP000002253874I2D: score=2 STRING: ENSP00000225387
    ABCC8Q094283, ENSP000003744674I2D: score=2 STRING: ENSP00000374467
    CRYBB1P536742MINT-5162051
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007601visual perception TAS8626774

    Find genes that share ontologies with CRYBB1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CRYBB1 (CRBB1)

    1 DrugBank Compound for CRYBB1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Double Oxidized Cysteine-- --target----



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CRYBB1 gene: 
    NM_001887.3  

    Unigene Cluster for CRYBB1:

    Crystallin, beta B1
    Hs.37135  [show with all ESTs]
    Unigene Representative Sequence: BC036790
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000215939(uc003acy.1)
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      QuantiFast Probe-based Assays in human, mouse, rat CRYBB1

    Additional mRNA sequence: 

    BC036790.1 CR456425.1 U35340.1 

    5 DOTS entries:

    DT.97847879  DT.91748498  DT.91748503  DT.75140199  DT.97803663 

    Selected AceView cDNA sequences (see all 141):

    BM697681 BF726742 BC036790 BU735459 BM706288 BF726282 BM705523 BM696578 
    BM722129 BF726675 BM696341 CD674021 BM667858 BU584587 BF726666 BM670096 
    BM668033 AW294178 BU735455 BM679075 BM697025 BU735123 BF727049 BF726350 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CRYBB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CRYBB1 Expression
    About this image


    CRYBB1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 5 entries
             Secondary Lens Fiber Cells Lens
             Human Lens Epithelial Cells (HLEpiC)   
             lens   
     
     Epithelial Cells
             Secondary Lens Fiber Cells Lens
             Human Lens Epithelial Cells (HLEpiC)   
    CRYBB1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CRYBB1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.37135
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CRYBB1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Crybb11 , 5 crystallin, beta B11, 5 81.09(n)1
    80.25(a)1
      5 (54.63 cM)5
    129601  NM_023695.21  NP_076184.11 
     1122558155 
    chicken
    (Gallus gallus)
    Aves CRYBB11 crystallin, beta B1 75.56(n)
    70.48(a)
      374000  NM_204180.1  NP_989511.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3977302 beta B1 crystallin 74.47(n)    D88186.1 
    zebrafish
    (Danio rerio)
    Actinopterygii crybb12 crystallin, beta B1 77.4(n)   114418  AJ317957.1 


    ENSEMBL Gene Tree for CRYBB1 (if available)
    TreeFam Gene Tree for CRYBB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CRYBB1 gene
    CRYBB32  CRYGB2  CRYBA42  CRYBA12  CRYBB22  CRYGD2  CRYGA2  CRYGC2  
    CRYBA22  CRYGN2  CRYGS2  
    13 SIMAP similar genes for CRYBB1 using alignment to 1 protein entry:     CRBB1_HUMAN:
    CRYBB3    CRYBB2    CRYBA1    CRYBA4    CRYBA2    CRYGS
    CRYGA    CRYBG3    CRYGB    CRYGC    CRYGD    DKFZp434L1713
    AIM1L

    Find genes that share paralogs with CRYBB1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CRYBB1 (see all 520)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0700304
    Cataract 17, multiple types (CTRCT17)4--see VAR_0700302 V F mis40--------
    rs743154881,2
    Cpathogenic110918879(-) AGTGGG/TGAGCC 2 G * stg10--------
    rs28773271,2
    C,F,H--9947635(+) ATGCCA/C/GGACCT 1 -- int111NS EA NA CSA 1249
    rs676371331,2
    C--9947635(+) ATGCC-/GGACCT 1 -- int11Minor allele frequency- G:0.00CSA 2
    rs759669741,2
    C--9947635(+) ATGCC-/GGACCTC 1 -- int10--------
    rs1833599381,2
    --10918361(+) ATCCAG/TTCAGG 1 -- ds50010--------
    rs1426333531,2
    --10918371(+) GACCCA/GGAAAC 1 -- ds50010--------
    rs1876148951,2
    --10918519(+) CCTTAC/TTCATT 1 -- ds50010--------
    rs1460378901,2
    --10918526(+) CATTTC/TTGCCT 1 -- ds50010--------
    rs1386353961,2
    --10918529(+) TTCTGC/TCTACA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for CRYBB1 (26995242 - 27014052 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CRYBB1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv267667CNV Insertion20981092
    esv273297CNV Insertion20981092
    dgv1397e1CNV Complex17122850
    nsv7350OTHER Inversion18451855

    Human Gene Mutation Database (HGMD): CRYBB1
    Locus Specific Mutation Databases (LSDB): CRYBB1

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600929   
    OMIM disorders: 611544  
    UniProtKB/Swiss-Prot: CRBB1_HUMAN, P53674
  • Cataract 17, multiple types (CTRCT17) [MIM:611544]: An opacification of the crystalline lens of the eye
    that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a
    portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an
    opacity, the greater the impact on visual function. CTRCT17 includes nuclear and pulverulent cataracts, among
    others. Nuclear cataracts affect the central nucleus of the eye, are often not highly visually significant. The
    density of the opacities varies greatly from fine dots to a dense, white and chalk-like, central cataract. The
    condition is usually bilateral. Nuclear cataracts are often combined with opacified cortical fibers encircling
    the nuclear opacity, which are referred to as cortical riders. Pulverulent cataracts are characterized by a
    dust-like, 'pulverised' appearance of the opacities which can be found in any part of the lens. Note=The disease
    is caused by mutations affecting the gene represented in this entry
  • Note=CRYBB1 mutations may be a cause of congenital cataract and microcornea syndrome (CCMC), a disease
    characterized by the association of congenital cataract and microcornea without any other systemic anomaly or
    dysmorphism. Clinical findings include a corneal diameter inferior to 10 mm in both meridians in an otherwise
    normal eye, and an inherited cataract, which is most often bilateral posterior polar with opacification in the
    lens periphery. The cataract progresses to form a total cataract after visual maturity has been achieved,
    requiring cataract extraction in the first to third decade of life (PubMed:16110300 and PubMed:21972112)

  • 5 diseases for CRYBB1:    
    About MalaCards
    cataract 17, multiple types    cataract, congenital nuclear, autosomal recessive 3    cataract 4, multiple types    cataracts, autosomal dominant
    cataract 1, multiple types

    1 disease from the University of Copenhagen DISEASES database for CRYBB1:
    Senile cataract

    Find genes that share disorders with CRYBB1           About GenesLikeMe

    3 Novoseek inferred disease relationships for CRYBB1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cataract, autosomal dominant 93.5 2 12360425 (2)
    congenital cataract 83.9 6 17531125 (3), 17460281 (2), 19461930 (1)
    cataract 65.8 8 19461930 (2), 20450675 (1), 12360425 (1), 17531125 (1) (see all 5)


    Export disorders for CRYBB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CRYBB1 gene, integrated from 10 sources (see all 52):
    (articles sorted by number of sources associating them with CRYBB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Assignment of the beta B1 crystallin gene (CRYBB1) to human chromosome 22 and mouse chromosome 5. (PubMed id 8575764)1, 2, 3, 9 Hulsebos T.J.M.... Copeland N.G. (Genomics 1995)
    2. A nonsense mutation in CRYBB1 associated with autosomal dominant cataract linked to human chromosome 22q. (PubMed id 12360425)1, 2, 3, 9 Mackay D.S....Shiels A. (Am. J. Hum. Genet. 2002)
    3. Homozygous CRYBB1 deletion mutation underlies autosomal recessive congenital cataract. (PubMed id 17460281)1, 2, 9 Cohen D.... Birk O.S. (Invest. Ophthalmol. Vis. Sci. 2007)
    4. A novel mutation in CRYBB1 associated with congenital cataract- microcornea syndrome: the p.Ser129Arg mutation destabilizes the betaB1/betaA3-crystallin heteromer but not the betaB1-crystallin homomer. (PubMed id 21972112)1, 2 Wang K.J.... Zhu S.Q. (Hum. Mutat. 2011)
    5. CRYBB1 mutation associated with congenital cataract and microcornea. (PubMed id 16110300)1, 2 Willoughby C.E.... Heon E. (Mol. Vis. 2005)
    6. Oligomerization and phase transitions in aqueous solutions of native and truncated human beta B1-crystallin. (PubMed id 15667225)1, 2 Annunziata O.... Benedek G.B. (Biochemistry 2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (Genome Biol. 2004)
    9. Crystal structure of truncated human betaB1-crystallin. (PubMed id 14573871)1, 2 Van Montfort R.L.... Slingsby C. (Protein Sci. 2003)
    10. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I.... Wright H. (Nature 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1414 HGNC: 2397 AceView: CRYBB1 Ensembl:ENSG00000100122 euGenes: HUgn1414
    ECgene: CRYBB1 H-InvDB: CRYBB1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CRYBB1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CRYBB1 gene:
    Search GeneIP for patents involving CRYBB1

    GeneCards and IP:
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