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CRYBA2 Gene

protein-coding   GIFtS: 53
GCID: GC02M219854

Crystallin, Beta A2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Crystallin, Beta A21 2
Beta-Crystallin A22
Eye Lens Structural Protein2
Beta-A2 Crystallin3

External Ids:    HGNC: 23951   Entrez Gene: 14122   Ensembl: ENSG000001634997   OMIM: 6008365   UniProtKB: P536723   

Export aliases for CRYBA2 gene to outside databases

Previous GC identifers: GC02M217870 GC02M218576 GC02M219818 GC02M220057 GC02M219680 GC02M219563 GC02M211708


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CRYBA2 Gene:
Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class
constitutes the major proteins of the vertebrate eye, which function to maintain the transparency and refractive
index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are
made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are
divided into alpha, beta, and gamma families; beta and gamma crystallins are also defined as a superfamily. Alpha
and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins:
four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most
heterogeneous, differ by the presence of the C-terminal extension (present in the basic group but absent in the
acidic group). Beta-crystallins form aggregates of different sizes and are able to form homodimers through
self-association or heterodimers with other beta-crystallins. This gene is a beta acidic group member. Three
alternatively spliced transcript variants encoding identical proteins have been reported. (provided by RefSeq,
Jul 2008)

GeneCards Summary for CRYBA2 Gene:
CRYBA2 (crystallin, beta A2) is a protein-coding gene. Diseases associated with CRYBA2 include cataract, and myopathy. GO annotations related to this gene include structural constituent of eye lens and protein homodimerization activity. An important paralog of this gene is CRYBB3.

UniProtKB/Swiss-Prot: CRBA2_HUMAN, P53672
Function: Crystallins are the dominant structural components of the vertebrate eye lens




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the CRYBA2 gene promoter:
         NRSF form 1   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCRYBA2 promoter sequence
   Search Chromatin IP Primers for CRYBA2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CRYBA2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q35   Ensembl cytogenetic band:  2q35   HGNC cytogenetic band: 2q35

CRYBA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRYBA2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M219854:  view genomic region     (about GC identifiers)

Start:
219,854,911 bp from pter      End:
219,858,143 bp from pter
Size:
3,233 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CRBA2_HUMAN, P53672 (See protein sequence)
Recommended Name: Beta-crystallin A2  
Size: 197 amino acids; 22096 Da
Subunit: Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be
stabilized through interactions between the N-terminal arms (By similarity)
Secondary accessions: Q4ZFX0 Q9Y562

Explore the universe of human proteins at neXtProt for CRYBA2: NX_P53672

Explore proteomics data for CRYBA2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CRYBA2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_476434.1  NP_476435.1  

    ENSEMBL proteins: 
     ENSP00000375946   ENSP00000295728   ENSP00000395120  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR001064 Beta/gamma_crystallin
     IPR011024 G_crystallin-rel

    Graphical View of Domain Structure for InterPro Entry P53672

    ProtoNet protein and cluster: P53672

    2 Blocks protein domains:
    IPB001064 Beta and gamma crystallin
    IPB011024 Gamma-crystallin related


    UniProtKB/Swiss-Prot: CRBA2_HUMAN, P53672
    Domain: Has a two-domain beta-structure, folded into four very similar Greek key motifs
    Similarity: Belongs to the beta/gamma-crystallin family
    Similarity: Contains 4 beta/gamma crystallin 'Greek key' domains


    CRYBA2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CRBA2_HUMAN, P53672
    Function: Crystallins are the dominant structural components of the vertebrate eye lens

         Genatlas biochemistry entry for CRYBA2:
    crystallin,beta polypeptide A2

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005212structural constituent of eye lens IEA--
    GO:0042803protein homodimerization activity IEA--
         
    CRYBA2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CRYBA2:
     Cell cycle / mitosis defect  Lamellipodia and high actin ra 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Cryba2):
     vision/eye 

    CRYBA2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CRYBA2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CRYBA2
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    miRTarBase miRNAs that target CRYBA2:
    hsa-mir-335-5p (MIRT017256)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    extracellular2
    nucleus2
    golgi apparatus1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--

    CRYBA2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CRYBA2
    Interactions:

        Search GeneGlobe Interaction Network for CRYBA2

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for CRYBA2 (P536722, 3 ENSP000002957284) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALCOCO1Q9P1Z22, 3, ENSP000002620594MINT-67789 I2D: score=5 STRING: ENSP00000262059
    CRYBB3P269982, 3, ENSP000002158554MINT-5161919 I2D: score=2 STRING: ENSP00000215855
    CRYBB2P433202, 3MINT-5162081 I2D: score=2 
    CRYBB1P536742, 3, ENSP000002159394MINT-5162066 I2D: score=2 STRING: ENSP00000215939
    TRIP13Q156453, ENSP000001663454I2D: score=1 STRING: ENSP00000166345
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002088lens development in camera-type eye IEA--
    GO:0008150biological_process ND--

    CRYBA2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CRYBA2 (CRBA2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CRYBA2 gene (2 alternative transcripts): 
    NM_057093.1  NM_057094.1  

    Unigene Cluster for CRYBA2:

    Crystallin, beta A2
    Hs.415790  [show with all ESTs]
    Unigene Representative Sequence: BM910348
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000392096(uc002vjj.1) ENST00000496566 ENST00000487181 ENST00000295728(uc002vjk.1)
    ENST00000453769 ENST00000490678
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      QuantiFast Probe-based Assays in human, mouse, rat CRYBA2

    Additional mRNA sequence: 

    AF166331.1 BC006285.2 BT007447.1 

    4 DOTS entries:

    DT.97847079  DT.92424408  DT.92424406  DT.100026196 

    Selected AceView cDNA sequences (see all 90):

    BC006285 BF726178 BM697189 BM705439 BF727353 AF166331 BF726158 BU734625 
    BM668066 BF727033 BM673256 BM697005 BM699827 BU734840 NM_005209 BM706068 
    BI092258 BF726257 NM_057093 BF726409 BM696635 BM667943 BU734582 BF727318 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CRYBA2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b
    SP1:                          -     -                     
    SP2:                          -     -                     
    SP3:                                                      
    SP4:                                                      


    ECgene alternative splicing isoforms for CRYBA2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CRYBA2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCTGGGCCA
    CRYBA2 Expression
    About this image


    CRYBA2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Pancreas (Endocrine System)    fully expand to see all 4 entries
             Endocrine Progenitor Cells Ventral Pancreatic Bud
     
     Eye (Sensory Organs)
             Lens
     
     Neural Tube (Nervous System)
             Metencephalon
     
     Brain (Nervous System)
             Medulla Oblongata
    CRYBA2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CRYBA2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.415790
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CRYBA2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cryba21 , 5 crystallin, beta A21, 5 89.13(n)1
    91.85(a)1
      1 (38.54 cM)5
    129581  NM_021541.31  NP_067516.11 
     748899345 
    chicken
    (Gallus gallus)
    Aves CRYBA21 crystallin, beta A2 73.95(n)
    66.67(a)
      373999  NM_204179.1  NP_989510.1 
    lizard
    (Anolis carolinensis)
    Reptilia CRYBA26
    crystallin, beta A2
    64(a)
    1 ↔ 1
    1(87821571-87832118)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.16112 Xenopus laevis transcribed sequence with weak similarity more 76.11(n)    BX846834.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.293732 Transcribed sequence with weak similarity to protein more 76.83(n)    CK352563.1 


    ENSEMBL Gene Tree for CRYBA2 (if available)
    TreeFam Gene Tree for CRYBA2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CRYBA2 gene
    CRYBB32  CRYGB2  CRYBA42  CRYBA12  CRYBB22  CRYGD2  CRYGA2  CRYBB12  
    CRYGC2  CRYGN2  CRYGS2  
    15 SIMAP similar genes for CRYBA2 using alignment to 2 protein entries:     CRBA2_HUMAN (see all proteins):
    CRYBA1    CRYBA4    CRYBB3    CRYBB1    CRYGN    CRYBB2
    CRYGA    DKFZp434A0627    CRYBG3    CRYGS    CRYGB    AIM1
    CRYGC    CRYGD    DKFZp434L1713

    CRYBA2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CRYBA2 (see all 135)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs769785651,2
    C,F--219239168(+) CAAGTC/TCCCAA 2 -- int11Minor allele frequency- T:0.01NA 120
    rs1429696451,2
    C--219239277(+) ACTCAC/TGCTCC 2 -- spd11Minor allele frequency- T:0.00NA 4552
    rs2012855361,2
    --219239299(+) TGAGGA/GAACCC 4 S F mis10--------
    rs412726911,2
    C--219239398(+) ACAGTA/GTCACA 4 T I mis10--------
    rs1893702421,2
    C--219239407(+) CACGGA/CTGTCA 4 S I mis10--------
    rs613485561,2
    C,F--219239436(+) GCAAGA/GTCAGG 2 -- int14Minor allele frequency- G:0.01WA CSA EU 1447
    rs571208001,2
    C,F--219239512(+) GCACCT/ACACAA 2 -- int11Minor allele frequency- A:0.50WA 2
    rs1918783311,2
    --219239561(+) CTCACC/GCCATC 2 -- int10--------
    rs1844030411,2
    --219239621(+) TGGCCC/TCTCCC 2 -- int10--------
    rs1146504281,2
    C,F--219239701(+) GCATCT/CTGTGA 2 -- int11Minor allele frequency- C:0.08WA 118

    HapMap Linkage Disequilibrium report for CRYBA2 (219854911 - 219858143 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CRYBA2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv834542CNV Gain17160897

    Human Gene Mutation Database (HGMD): CRYBA2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CRYBA2
    DNA2.0 Custom Variant and Variant Library Synthesis for CRYBA2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600836    OMIM disorders: --

    UniProtKB/Swiss-Prot: CRBA2_HUMAN, P53672
  • Note=Defects in CRYBA2 may be a cause of congenital cataract. Cataract is an opacification of the
    crystalline lens of the eye that frequently resulting in visual impairment or blindness. Opacities vary in
    morphology, are often confined to a portion of the lens, and may be static or progressive

  • 3 diseases for CRYBA2:    
    About MalaCards
    cataract    myopathy    pancreatitis


    CRYBA2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CRYBA2
    Human Genome Epidemiology (HuGE) Navigator: CRYBA2 (1 document)

    Export disorders for CRYBA2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CRYBA2 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with CRYBA2)
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    1. Identification of the human beta A2 crystallin gene (CRYBA2): localization of the gene on human chromosome 2 and of the homologous gene on mouse chromosome 1. (PubMed id 7490092)1, 2, 3, 9 Hulsebos T.J.M.... Copeland N.G. (Genomics 1995)
    2. Whole exome sequencing in dominant cataract identifies a new causative factor, CRYBA2, and a variety of novel alleles in known genes. (PubMed id 23508780)1, 2 Reis L.M....Semina E.V. (Hum. Genet. 2013)
    3. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PubMed id 20546612)1, 4 Zhao J....Grant S.F. (BMC Med. Genet. 2010)
    4. Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)1, 4 Gudbjartsson D.F....Stefansson K. (Nat. Genet. 2008)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Expression of betaA2-crystallin in human lenses. (PubMed id 12907171)1, 3 Lapko V.N....Smith J.B. (Exp. Eye Res. 2003)
    7. Mutations in GMPPA cause a glycosylation disorder characterized by intellectual disability and autonomic dysfunction. (PubMed id 24035193)2 Koehler K....HA1bner C.A. (Am. J. Hum. Genet. 2013)
    8. Cell stress molecules in the skeletal muscle of GNE myopathy. (PubMed id 23496965)1 Fischer C....Schmidt J. (BMC Neurol 2013)
    9. An empirical framework for binary interactome mapping. (PubMed id 19060904)1 Venkatesan K....Vidal M. (Nat. Methods 2009)
    10. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (Nature 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1412 HGNC: 2395 AceView: CRYBA2 Ensembl:ENSG00000163499 euGenes: HUgn1412
    ECgene: CRYBA2 H-InvDB: CRYBA2

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CRYBA2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CRYBA2 gene:
    Search GeneIP for patents involving CRYBA2

    GeneCards and IP:
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