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Aliases for CRYAB Gene

Aliases for CRYAB Gene

  • Crystallin, Alpha B 2 3
  • CRYA2 3 4 6
  • Renal Carcinoma Antigen NY-REN-27 3 4
  • Heat Shock Protein Beta-5 3 4
  • Rosenthal Fiber Component 3 4
  • CTRCT16 3 6
  • CMD1II 3 6
  • HSPB5 3 4
  • CTPP2 3 6
  • MFM2 3 6
  • Epididymis Secretory Protein Li 101 3
  • Heat-Shock 20 KD Like-Protein 3
  • Alpha-Crystallin B Chain 3
  • Alpha(B)-Crystallin 4
  • HEL-S-101 3

External Ids for CRYAB Gene

Previous HGNC Symbols for CRYAB Gene

  • CRYA2

Previous GeneCards Identifiers for CRYAB Gene

  • GC11M114132
  • GC11M113291
  • GC11M111813
  • GC11M111316
  • GC11M111284
  • GC11M107703

Summaries for CRYAB Gene

Entrez Gene Summary for CRYAB Gene

  • Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

GeneCards Summary for CRYAB Gene

CRYAB (Crystallin, Alpha B) is a Protein Coding gene. Diseases associated with CRYAB include myopathy, myofibrillar, 2 and cataract 16, multiple types. Among its related pathways are Protein processing in endoplasmic reticulum. GO annotations related to this gene include protein homodimerization activity and microtubule binding. An important paralog of this gene is CRYAA.

UniProtKB/Swiss-Prot for CRYAB Gene

  • May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions

Gene Wiki entry for CRYAB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRYAB Gene

Genomics for CRYAB Gene

Regulatory Elements for CRYAB Gene

Genomic Location for CRYAB Gene

111,908,565 bp from pter
111,923,722 bp from pter
15,158 bases
Minus strand

Genomic View for CRYAB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CRYAB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRYAB Gene

Proteins for CRYAB Gene

  • Protein details for CRYAB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Alpha-crystallin B chain
    Protein Accession:
    Secondary Accessions:
    • B0YIX0
    • O43416
    • Q9UC37
    • Q9UC38
    • Q9UC39
    • Q9UC40
    • Q9UC41

    Protein attributes for CRYAB Gene

    175 amino acids
    Molecular mass:
    20159 Da
    Quaternary structure:
    • Heteropolymer composed of three CRYAA and one CRYAB subunits. Aggregates with homologous proteins, including the small heat shock protein HSPB1, to form large heteromeric complexes. Inter-subunit bridging via zinc ions enhances stability, which is crucial as there is no protein turn over in the lens. Interacts with HSPBAP1 and TTN/titin.

    Three dimensional structures from OCA and Proteopedia for CRYAB Gene

neXtProt entry for CRYAB Gene

Proteomics data for CRYAB Gene at MOPED

Post-translational modifications for CRYAB Gene

  • Glycosylation at Thr170
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for CRYAB (AlphaB Crystallin/CRYAB)
  • Cell Signaling Technology (CST) Antibodies for CRYAB (CRYAB)

No data available for DME Specific Peptides for CRYAB Gene

Domains for CRYAB Gene

Gene Families for CRYAB Gene

  • HSPB :Heat shock proteins / HSPB

Suggested Antigen Peptide Sequences for CRYAB Gene

Graphical View of Domain Structure for InterPro Entry



  • P02511
  • Belongs to the small heat shock protein (HSP20) family.
genes like me logo Genes that share domains with CRYAB: view

Function for CRYAB Gene

Molecular function for CRYAB Gene

GENATLAS Biochemistry: crystallin,alpha polypeptide 2 (alphaB),selectively expressed in slow-twitch oxidative muscle fibers,with chaperone-like activity and maintenance of cytoskeletal network in muscle,involved in desmin related myopathy and in cataract,alpha crystallin/small hsp family
UniProtKB/Swiss-Prot Function: May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions

Gene Ontology (GO) - Molecular Function for CRYAB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005212 structural constituent of eye lens IEA --
GO:0005515 protein binding IPI 11700327
GO:0008017 microtubule binding IEA --
GO:0008092 cytoskeletal protein binding --
GO:0042802 identical protein binding IPI 12601044
genes like me logo Genes that share ontologies with CRYAB: view
genes like me logo Genes that share phenotypes with CRYAB: view

Animal Models for CRYAB Gene

MGI Knock Outs for CRYAB:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CRYAB

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for CRYAB Gene

Localization for CRYAB Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRYAB Gene

Cytoplasm. Nucleus. Note=Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles.

Subcellular locations from

Jensen Localization Image for CRYAB Gene COMPARTMENTS Subcellular localization image for CRYAB gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 4
cytoskeleton 3
golgi apparatus 2
mitochondrion 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CRYAB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 19464326
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with CRYAB: view

Pathways for CRYAB Gene

genes like me logo Genes that share pathways with CRYAB: view

Pathways by source for CRYAB Gene

1 KEGG pathway for CRYAB Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for CRYAB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0002088 lens development in camera-type eye IEA --
GO:0006457 protein folding IEA --
GO:0006936 muscle contraction TAS 9731540
GO:0007021 tubulin complex assembly IEA --
genes like me logo Genes that share ontologies with CRYAB: view

Compounds for CRYAB Gene

(24) Novoseek inferred chemical compound relationships for CRYAB Gene

Compound -log(P) Hits PubMed IDs
succinimide 48.8 1
methionine sulfoxide 47.4 2
sodium arsenite 27.9 1
chloramphenicol 18.2 2
manganese superoxide 13.7 2
genes like me logo Genes that share compounds with CRYAB: view

Transcripts for CRYAB Gene

Unigene Clusters for CRYAB Gene

Crystallin, alpha B:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CRYAB

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CRYAB Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c
SP1: - -
SP2: -

Relevant External Links for CRYAB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CRYAB Gene

mRNA expression in normal human tissues for CRYAB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CRYAB Gene

This gene is overexpressed in Heart - Left Ventricle (10.7), Muscle - Skeletal (5.5), and Heart - Atrial Appendage (5.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CRYAB Gene

SOURCE GeneReport for Unigene cluster for CRYAB Gene Hs.53454

mRNA Expression by UniProt/SwissProt for CRYAB Gene

Tissue specificity: Lens as well as other tissues
genes like me logo Genes that share expressions with CRYAB: view

In Situ Assay Products

Orthologs for CRYAB Gene

This gene was present in the common ancestor of animals.

Orthologs for CRYAB Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CRYAB 35
  • 99.81 (n)
  • 99.43 (a)
  • 99 (a)
(Bos Taurus)
Mammalia CRYAB 35
  • 93.71 (n)
  • 97.71 (a)
  • 98 (a)
(Canis familiaris)
Mammalia CRYAB 35
  • 94.48 (n)
  • 98.29 (a)
  • 98 (a)
(Mus musculus)
Mammalia Cryab 35
  • 91.24 (n)
  • 97.71 (a)
Cryab 16
Cryab 36
  • 98 (a)
(Monodelphis domestica)
Mammalia CRYAB 36
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia CRYAB 36
  • 81 (a)
(Rattus norvegicus)
Mammalia Cryab 35
  • 91.81 (n)
  • 97.14 (a)
(Gallus gallus)
Aves CRYAB 35
  • 74.14 (n)
  • 77.01 (a)
  • 78 (a)
(Anolis carolinensis)
Reptilia CRYAB 36
  • 81 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.7573 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cryab 35
  • 67.05 (n)
  • 69.36 (a)
Str.8597 35
(Danio rerio)
Actinopterygii cryaba 36
  • 62 (a)
cryabb 35
  • 65.85 (n)
  • 63.19 (a)
cryabb 36
  • 57 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007162 35
  • 52.89 (n)
  • 49.33 (a)
fruit fly
(Drosophila melanogaster)
Insecta l(2)efl 35
  • 55.63 (n)
  • 47.02 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.195 36
  • 36 (a)
Species with no ortholog for CRYAB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CRYAB Gene

Gene Tree for CRYAB (if available)
Gene Tree for CRYAB (if available)

Paralogs for CRYAB Gene

Paralogs for CRYAB Gene

genes like me logo Genes that share paralogs with CRYAB: view

Variants for CRYAB Gene

Sequence variations from dbSNP and Humsavar for CRYAB Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1801966 -- 111,908,766(-) AGAAA(A/T)AGATG stop-lost, reference
rs2070894 -- 111,910,113(-) TTGAT(C/T)GCCTT intron-variant
rs3179808 -- 111,908,624(-) CAACA(A/G)ATAAC utr-variant-3-prime
rs11214039 -- 111,909,104(+) AGCTT(C/T)GTTTC intron-variant
rs11549441 -- 111,908,778(-) CCGCA(C/G)CCCCC missense, reference

Structural Variations from Database of Genomic Variants (DGV) for CRYAB Gene

Variant ID Type Subtype PubMed ID
nsv482162 CNV Loss 20164927

Relevant External Links for CRYAB Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRYAB Gene

Disorders for CRYAB Gene

(4) OMIM Diseases for CRYAB Gene (123590)


  • Myopathy, myofibrillar, 2 (MFM2) [MIM:608810]: A neuromuscular disorder that results in weakness of the proximal and distal limb muscles, weakness of the neck, velopharynx and trunk muscles, hypertrophic cardiomyopathy, and cataract in a subset of patients. {ECO:0000269 PubMed:14681890, ECO:0000269 PubMed:21920752, ECO:0000269 PubMed:9731540}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Cataract 16, multiple types (CTRCT16) [MIM:613763]: An opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function. CTRCT16 includes posterior polar cataract, among others. Posterior polar cataract is a subcapsular opacity, usually disk-shaped, located at the back of the lens. {ECO:0000269 PubMed:11577372}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Myopathy, myofibrillar, fatal infantile hypertonic, alpha-B crystallin-related (MFMFIH-CRYAB) [MIM:613869]: A muscular dystrophy with onset in the first weeks of life after a normal neonatal period. Affected infants show rapidly progressive muscular rigidity of the trunk and limbs associated with increasing respiratory difficulty resulting in death before age 3 years. {ECO:0000269 PubMed:21337604}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Cardiomyopathy, dilated 1II (CMD1II) [MIM:615184]: A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. {ECO:0000269 PubMed:16483541, ECO:0000269 PubMed:16793013}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(3) University of Copenhagen DISEASES for CRYAB Gene

(55) Novoseek inferred disease relationships for CRYAB Gene

Disease -log(P) Hits PubMed IDs
alexanders disease 85.2 15
desmin-related myopathy 79.7 4
shock 72.1 66
congenital cataract 68.8 6
myopathy 60.1 6

Relevant External Links for CRYAB

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CRYAB: view

Publications for CRYAB Gene

  1. Simultaneous racemization and isomerization at specific aspartic acid residues in alpha B-crystallin from the aged human lens. (PMID: 8142454) Fujii N. … Harada K. (Biochim. Biophys. Acta 1994) 3 4 23
  2. Copurification of small heat shock protein with alpha B crystallin from human skeletal muscle. (PMID: 1560006) Kato K. … Asano T. (J. Biol. Chem. 1992) 3 4 23
  3. Accumulation of alpha B-crystallin in brains of patients with Alexander's disease is not due to an abnormality of the 5'-flanking and coding sequence of the genomic DNA. (PMID: 1407707) Iwaki A. … Sakaki Y. (Neurosci. Lett. 1992) 3 4 23
  4. Alpha-B crystallin gene (CRYAB) mutation causes dominant congenital posterior polar cataract in humans. (PMID: 11577372) Berry V. … Quinlan R.A. (Am. J. Hum. Genet. 2001) 3 4 23
  5. Alteration of protein-protein interactions of congenital cataract crystallin mutants. (PMID: 12601044) Fu L. … Liang J.J.-N. (Invest. Ophthalmol. Vis. Sci. 2003) 3 4 23

Products for CRYAB Gene

Sources for CRYAB Gene

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