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CRY2 Gene

protein-coding   GIFtS: 63
GCID: GC11P045868

Cryptochrome Circadian Clock 2

(Previous name: cryptochrome 2 (photolyase-like))
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cryptochrome Circadian Clock 21 2     cryptochrome-22
Cryptochrome 2 (Photolyase-Like)1 2     Growth-Inhibiting Protein 372
HCRY22     KIAA06583
PHLL22     

External Ids:    HGNC: 23851   Entrez Gene: 14082   Ensembl: ENSG000001216717   OMIM: 6037325   UniProtKB: Q49AN03   

Export aliases for CRY2 gene to outside databases

Previous GC identifers: GC11P047653 GC11P046558 GC11P045866 GC11P045833 GC11P045825 GC11P045575


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CRY2 Gene:
This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core
oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but
then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL.
Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely
conserved across plants and animals. Two transcript variants encoding different isoforms have been found for this
gene. (provided by RefSeq, Feb 2014)

GeneCards Summary for CRY2 Gene:
CRY2 (cryptochrome circadian clock 2) is a protein-coding gene. GO annotations related to this gene include phosphatase binding and single-stranded DNA binding. An important paralog of this gene is CRY1.

UniProtKB/Swiss-Prot: CRY2_HUMAN, Q49AN0
Function: Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK NPAS2-ARNTL E box-mediated
transcription. Acts, in conjunction with CRY1, in maintaining period length and circadian rhythmicity. Has no
photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus.
May inhibit CLOCK NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_009237.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the CRY2 gene promoter:
         CREB   deltaCREB   LCR-F1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CRY2 promoter sequence
   Search Chromatin IP Primers for CRY2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CRY2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p11.2   Ensembl cytogenetic band:  11p11.2   HGNC cytogenetic band: 11p11.2

CRY2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRY2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P045868:  view genomic region     (about GC identifiers)

Start:
45,868,669 bp from pter      End:
45,904,799 bp from pter
Size:
36,131 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CRY2_HUMAN, Q49AN0 (See protein sequence)
Recommended Name: Cryptochrome-2  
Size: 593 amino acids; 66947 Da
Cofactor: Binds 1 FAD per subunit. Only a minority of the protein molecules contain bound FAD. Contrary to the
situation in photolyases, the FAD is bound in a shallow, surface-exposed pocket (By similarity)
Cofactor: Binds 1 5,10-methenyltetrahydrofolate non-covalently per subunit (By similarity)
Subunit: Component of the circadian core oscillator, which includes the CRY proteins, CLOCK or NPAS2, ARNTL or
ARNTL2, CSNK1D and/or CSNK1E, TIMELESS, and the PER proteins. Interacts directly with PER1 and PER2 C-terminal
domains. Interaction with PER2 inhibits its ubiquitination and vice versa. Interacts with NFIL3. Interacts with
FBXL3 and FBXL21. FBXL3, PER2 and the cofactor FAD compete for overlapping binding sites. FBXL3 cannot bind CRY2
that interacts already with PER2 or that contains bound FAD. Interacts with PPP5C (via TPR repeats); the
interaction downregulates the PPP5C phosphatase activity on CSNK1E
Sequence caution: Sequence=AAH35161.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact. Aberrant
splice sites; Sequence=BAG57993.1; Type=Erroneous termination; Positions=110; Note=Translated as Trp;
Sequence=BAG57993.1; Type=Erroneous translation; Note=Wrong choice of CDS;
Secondary accessions: B4DH32 O75148 Q8IV71
Alternative splicing: 2 isoforms:  Q49AN0-1   Q49AN0-2   (No experimental confirmation available. Ref.2 (BAG57993) sequence is in conflict in position: 9:H->L)

Explore the universe of human proteins at neXtProt for CRY2: NX_Q49AN0

Explore proteomics data for CRY2 at MOPED

Post-translational modifications: 

  • Phosphorylation on Ser-266 by MAPK is important for the inhibition of CLOCK-ARNTL-mediated transcriptional
    activity. Phosphorylation by CSKNE requires interaction with PER1 or PER2. Phosphorylated in a circadian manner
    at Ser-554 and Ser-558 in the suprachiasmatic nucleus (SCN) and liver. Phosphorylation at Ser-558 by DYRK1A
    promotes subsequent phosphorylation at Ser-554 by GSK3-beta: the two-step phosphorylation at the neighboring Ser
    residues leads to its proteasomal degradation (By similarity)1
  • Ubiquitinated by the SCF(FBXL3) and SCF(FBXL21) complexes, regulating the balance between degradation and
    stabilization. The SCF(FBXL3) complex is mainly nuclear and mediates ubiquitination and subsequent degradation of
    CRY2. In contrast, cytoplasmic SCF(FBXL21) complex-mediated ubiquitination leads to stabilize CRY2 and counteract
    the activity of the SCF(FBXL3) complex. The SCF(FBXL3) and SCF(FBXL21) complexes probably mediate ubiquitination
    at different Lys residues. The SCF(FBXL3) complex recognizes and binds CRY2 phosphorylated at Ser-554 and Ser-558
    (Probable)1
  • Ubiquitination2 at Lys126, Lys242, Lys348, Lys475, Lys504
  • Modification sites at PhosphoSitePlus

  • See CRY2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001120929.1  NP_066940.2  

    ENSEMBL proteins: 
     ENSP00000397419   ENSP00000406751  
    Reactome Protein details: Q49AN0

    CRY2 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for CRY2

     
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    antibodies-online proteins for CRY2 (6 products) 

     
    antibodies-online peptides for CRY2

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    antibodies-online kits for CRY2 (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR005101 Photolyase_FAD-bd/Cryptochr_C
     IPR006050 DNA_photolyase_N
     IPR014729 Rossmann-like_a/b/a_fold

    Graphical View of Domain Structure for InterPro Entry Q49AN0

    ProtoNet protein and cluster: Q49AN0

    UniProtKB/Swiss-Prot: CRY2_HUMAN, Q49AN0
    Similarity: Belongs to the DNA photolyase class-1 family
    Similarity: Contains 1 photolyase/cryptochrome alpha/beta domain


    Find genes that share domains with CRY2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CRY2_HUMAN, Q49AN0
    Function: Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK NPAS2-ARNTL E box-mediated
    transcription. Acts, in conjunction with CRY1, in maintaining period length and circadian rhythmicity. Has no
    photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus.
    May inhibit CLOCK NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL

         Gene Ontology (GO): Selected molecular function terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000989transcription factor binding transcription factor activity IDA15147242
    GO:0003677DNA binding IDA12627958
    GO:0003684damaged DNA binding IDA12627958
    GO:0003697single-stranded DNA binding IDA12627958
    GO:0003904NOT deoxyribodipyrimidine photo-lyase activity IDA8909283
         
    Find genes that share ontologies with CRY2           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for CRY2:
     Decreased influenza A/WSN/33 r  Increased circadian period len  Synthetic lethal with Ras 

         12 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Cry2):
     adipose tissue  behavior/neurological  cardiovascular system  growth/size/body  hematopoietic system 
     homeostasis/metabolism  immune system  integument  muscle  nervous system 
     skeleton  vision/eye 

    Find genes that share phenotypes with CRY2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CRY2: Cry2tm1Jhjh Cry2tm1Asn

       genOway: Develop your customized and physiologically relevant rodent model for CRY2

    miRNA
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    miRTarBase miRNAs that target CRY2:
    hsa-mir-340-5p (MIRT019611), hsa-mir-532-3p (MIRT037929), hsa-mir-33a-5p (MIRT028213), hsa-mir-130b-3p (MIRT020147), hsa-mir-93-5p (MIRT028006)

    Block miRNA regulation of human, mouse, rat CRY2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CRY2 (see all 61):
    hsa-miR-194* hsa-miR-142-5p hsa-let-7d hsa-miR-330-5p hsa-miR-106a hsa-miR-513a-5p hsa-miR-1224-3p hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmidCRY2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CRY2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): CRY2 (NM_021117)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRY2
    Addgene plasmids for CRY2 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRY2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CRY2_HUMAN, Q49AN0: Cytoplasm. Nucleus. Note=Translocated to the nucleus through interaction with other Clock
    proteins such as PER2 or ARNTL
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus5
    cytosol3
    endoplasmic reticulum1
    lysosome1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IDA9753616
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion ----

    Find genes that share ontologies with CRY2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CRY2 About    
    See pathways by source

    SuperPathContained pathways About
    1Circadian rhythm
    Circadian rhythm0.31
    Circadian Clock in Mammals0.31
    2Circadian Clock
    Circadian Clock0.66
    BMAL1-CLOCK/NPAS2 Activates Circadian Expression0.66
    3Selected targets of ESR1
    Selected targets of ESR1
    4Metabolic States and Circadian Oscillators
    Metabolic States and Circadian Oscillators
    5Diurnally regulated genes with circadian orthologs
    Diurnally regulated genes with circadian orthologs


    Find genes that share SuperPaths with CRY2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CRY2
        Metabolic States and Circadian Oscillators
    Circadian Clock in Mammals

    1 BioSystems Pathway for CRY2
        Diurnally regulated genes with circadian orthologs

    2 Reactome Pathways for CRY2
        Circadian Clock
    BMAL1:CLOCK,NPAS2 activates circadian gene expression


    1 Kegg Pathway  (Kegg details for CRY2):
        Circadian rhythm

        Pathway & Disease-focused RT2 Profiler PCR Array including CRY2: 
              Circadian Rhythms in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CRY2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CRY2 (Q49AN03 ENSP000004067514) via UniProtKB, MINT, STRING, and/or I2D (see all 77)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PER2O150553, ENSP000002546574I2D: score=4 STRING: ENSP00000254657
    RBBP4Q090283, ENSP000003625924I2D: score=3 STRING: ENSP00000362592
    CLOCKO155163, ENSP000003087414I2D: score=1 STRING: ENSP00000308741
    PPP2CBP627143, ENSP000002211384I2D: score=1 STRING: ENSP00000221138
    ARNTLO003273, ENSP000003743574I2D: score=2 STRING: ENSP00000374357
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA12397359
    GO:0000719NOT photoreactive repair IDA12627958
    GO:0006281DNA repair ----
    GO:0006351transcription, DNA-templated IEA--
    GO:0006606protein import into nucleus ----

    Find genes that share ontologies with CRY2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CRY2

    1 HMDB Compound for CRY2    About this table
    CompoundSynonyms CAS #PubMed Ids
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--

    1 Novoseek inferred chemical compound relationship for CRY2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pterin 74 1 20031915 (1)



    Find genes that share compounds with CRY2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CRY2 gene (2 alternative transcripts): 
    NM_001127457.2  NM_021117.3  

    Unigene Cluster for CRY2:

    Cryptochrome 2 (photolyase-like)
    Hs.532491  [show with all ESTs]
    Unigene Representative Sequence: BC035161
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000417225 ENST00000443527(uc009ykw.3 uc010rgn.2 uc010rgo.2)
    ENST00000496571 ENST00000532390 ENST00000473199 ENST00000533779 ENST00000525110
    ENST00000495237 ENST00000496667 ENST00000488962
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    Selected qRT-PCR Assays for microRNAs that regulate CRY2 (see all 61):
    hsa-miR-194* hsa-miR-142-5p hsa-let-7d hsa-miR-330-5p hsa-miR-106a hsa-miR-513a-5p hsa-miR-1224-3p hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmidCRY2 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat CRY2

    Additional mRNA sequence: 

    AB014558.1 AK001194.1 AK291260.1 AK294904.1 AK295627.1 AK302865.1 BC035161.1 BC041814.1 
    EU219622.1 

    8 DOTS entries:

    DT.416735  DT.91953414  DT.100785151  DT.92428331  DT.120756014  DT.120756030  DT.97859280  DT.95375211 

    Selected AceView cDNA sequences (see all 204):

    AA317777 BE536004 CB153797 BM719836 BM739092 AL546483 AI081990 CB111918 
    BM739018 BM756433 BI459617 BX486701 AB014558 AL040963 BQ890582 CB164749 
    CR621757 NM_021117 BX457232 BI036117 BI821041 BE674510 BM739949 BM756471 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CRY2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
    SP1:                                                                                -                           
    SP2:                    -                                                                                       
    SP3:                    -     -     -                                                                           
    SP4:                                                                                                            
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for CRY2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CRY2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGAAGAGAT
    CRY2 Expression
    About this image


    CRY2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
    CRY2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CRY2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.532491

    UniProtKB/Swiss-Prot: CRY2_HUMAN, Q49AN0
    Tissue specificity: Expressed in all tissues examined including fetal brain, fibroblasts, heart, brain, placenta,
    lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon
    and leukocytes. Highest levels in heart and skeletal muscle

        Pathway & Disease-focused RT2 Profiler PCR Array including CRY2: 
              Circadian Rhythms in human mouse rat

    Primer
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CRY2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cry21 , 5 cryptochrome 2 (photolyase-like)1, 5 90.97(n)1
    96.01(a)1
      2 (51.01 cM)5
    129531  NM_009963.41  NP_034093.11 
     924036465 
    chicken
    (Gallus gallus)
    Aves CRY21 cryptochrome 2 (photolyase-like) 79.26(n)
    88.05(a)
      374092  NM_204244.1  NP_989575.1 
    lizard
    (Anolis carolinensis)
    Reptilia CRY26
    cryptochrome 2 (photolyase-like)
    84(a)
    1 ↔ 1
    1(47791272-47829104)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.120802 Xenopus laevis cryptochrome 2b mRNA, complete cds 77.63(n)    AY049035.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cry31 cryptochrome 3 72.44(n)
    78.99(a)
      83774  NM_131786.2  NP_571861.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta phr6-43 DNA repair DNA (6-4) photolyase 53(a)
    (best of 2)
      2 38D2   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PHR16
    DNA photolyase involved in photoreactivation, repa...
    18(a)
    1 → many
    XV(1066839-1068536) YOR386W


    ENSEMBL Gene Tree for CRY2 (if available)
    TreeFam Gene Tree for CRY2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CRY2 gene
    CRY12  
    1 SIMAP similar gene for CRY2 using alignment to 4 protein entries:     CRY2_HUMAN (see all proteins):
    CRY1

    Find genes that share paralogs with CRY2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CRY2 (see all 685)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1854312851,2
    --45793284(+) TTATGA/GAGCCC 1 -- us2k10--------
    rs1897885211,2
    --45793347(+) ACAGGC/TCCTGC 1 -- us2k10--------
    rs104620261,2
    C,F--45793713(+) CACAGG/AGTTCA 1 -- us2k12Minor allele frequency- A:0.17NA EA 240
    rs20562601,2
    C,A,H--45793715(-) CGTGAG/ACCCTG 1 -- us2k112Minor allele frequency- A:0.27NA WA CSA EA 374
    rs1396580401,2
    C--45793781(+) CTCTGA/GGGTTA 1 -- us2k10--------
    rs1118218191,2
    C,F--45793798(+) AACCAC/ACTCCT 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1835438821,2
    --45793967(+) GTAAGC/TGGACT 1 -- us2k10--------
    rs1143203931,2
    C,F--45793983(+) AAACCT/CTTAAG 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1864294811,2
    --45793994(+) AGCCTA/GCCAAT 1 -- us2k10--------
    rs757866941,2
    C,F--45794158(+) AGAAAT/CTTCAG 1 -- us2k11Minor allele frequency- C:0.15WA 118

    HapMap Linkage Disequilibrium report for CRY2 (45868669 - 45904799 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CRY2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv307CNV Insertion18451855
    nsv897314CNV Loss21882294
    nsv516442CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CRY2
    DNA2.0 Custom Variant and Variant Library Synthesis for CRY2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603732    OMIM disorders: --


    Find genes that share disorders with CRY2           About GenesLikeMe

    1 Novoseek inferred disease relationship for CRY2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 18.5 2 20233903 (1), 20334671 (1)

    Genetic Association Database (GAD): CRY2
    Human Genome Epidemiology (HuGE) Navigator: CRY2 (28 documents)

    Export disorders for CRY2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CRY2 gene, integrated from 10 sources (see all 82):
    (articles sorted by number of sources associating them with CRY2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Putative human blue-light photoreceptors hCRY1 and hCRY2 are flavoproteins. (PubMed id 8909283)1, 2, 3, 9 Hsu D.S.... Sancar A. (Biochemistry 1996)
    2. CRY2 is associated with depression. (PubMed id 20195522)1, 4, 9 Lavebratt C....Schalling M. (PLoS ONE 2010)
    3. The core circadian gene Cryptochrome 2 influences breast cancer risk, possibly by mediating hormone signaling. (PubMed id 20233903)1, 4, 9 Hoffman A.E....Zhu Y. (Cancer Prev Res (Phila) 2010)
    4. Correlation between circadian gene variants and serum levels of sex steroids and insulin-like growth factor-I. (PubMed id 18990770)1, 4, 9 Chu L.W....Hsing A.W. (amp 2008)
    5. Characterization of photolyase/blue-light receptor homologs in mouse and human cells. (PubMed id 9801304)1, 2, 9 Kobayashi K....Yasui A. (Nucleic Acids Res. 1998)
    6. Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder. (PubMed id 20072116)1, 4, 9 Soria V....Urretavizcaya M. (Neuropsychopharmacology 2010)
    7. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. (PubMed id 20081858)1, 4, 9 Dupuis J....Barroso I. (Nat. Genet. 2010)
    8. Testing the circadian gene hypothesis in prostate cancer: a population-based case-control study. (PubMed id 19934327)1, 4, 9 Zhu Y....Stanford J.L. (Cancer Res. 2009)
    9. Clock genes may influence bipolar disorder susceptibility and dysfunctional circadian rhythm. (PubMed id 18228528)1, 4, 9 Shi J....Liu C. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008)
    10. Suggestive evidence for association of the circadian genes PERIOD3 and ARNTL with bipolar disorder. (PubMed id 16528748)1, 4, 9 Nievergelt C.M....Kelsoe J.R. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1408 HGNC: 2385 AceView: CRY2 Ensembl:ENSG00000121671 euGenes: HUgn1408
    ECgene: CRY2 Kegg: 1408 H-InvDB: CRY2

    (According to HUGE)
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    HUGE: KIAA0658

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CRY2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CRY2 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Cryptochrome

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CRY2 gene:
    Search GeneIP for patents involving CRY2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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