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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CRY2 Gene

protein-coding GIFtS: 61
GCID: GC11P045868

cryptochrome 2 (photolyase-like)

Explore 18 diseases affiliated with
CRY2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cryptochrome 2 (Photolyase-Like)¹ ²
HCRY2²
PHLL2²
Cryptochrome-2¹
Growth-Inhibiting Protein 37²
KIAA0658³

External Ids:	HGNC: 2385¹	Entrez Gene: 1408²	Ensembl: ENSG00000121671⁷	OMIM: 603732⁵	UniProtKB: Q49AN0³

Export aliases for CRY2 gene to outside databases

Previous GC identifers: GC11P047653 GC11P046558 GC11P045866 GC11P045833 GC11P045825 GC11P045575

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: CRY2_HUMAN, Q49AN0

Function: Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK NPAS2-ARNTL E box-mediated

transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no

photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May

inhibit CLOCK NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_009237.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CRY2 gene promoter:
CREB deltaCREB LCR-F1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CRY2 promoter sequence

Search SABiosciences Chromatin IP Primers for CRY2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CRY2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p11.2 Ensembl cytogenetic band: 11p11.2 HGNC cytogenetic band: 11p11.2

CRY2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRY2 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P045868: view genomic region (about GC identifiers)

Start:	45,868,669 bp from pter	End:	45,904,799 bp from pter
Size:	36,131 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CRY2_HUMAN, Q49AN0 (See protein sequence)

Recommended Name: Cryptochrome-2

Size: 593 amino acids; 66947 Da

Cofactor: Binds 1 FAD per subunit (By similarity)

Cofactor: Binds 1 5,10-methenyltetrahydrofolate non-covalently per subunit (By similarity)

Subunit: Component of the circadian core oscillator, which includes the CRY proteins, CLOCK or NPAS2, ARNTL or ARNTL2,

CSNK1D and/or CSNK1E, TIMELESS, and the PER proteins. Interacts directly with PER1 and PER2 C-terminal domains.

Interaction with PER2 inhibits its ubiquitination and vice versa. Interacts with NFIL3. Interacts with FBXL3

Subcellular location: Cytoplasm. Nucleus. Note=Translocated to the nucleus through interaction with other Clock

proteins such as PER2 or ARNTL

Sequence caution: Sequence=AAH35161.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact. Aberrant splice

sites; Sequence=BAG57993.1; Type=Erroneous termination; Positions=110; Note=Translated as Trp; Sequence=BAG57993.1;

Type=Erroneous translation; Note=Wrong choice of CDS;

Secondary accessions: B4DH32 O75148 Q8IV71

Alternative splicing: 2 isoforms: Q49AN0-1 Q49AN0-2 (No experimental confirmation available. Ref.2 (BAG57993) sequence is in conflict in position: 9:H->L)

Explore the universe of human proteins at neXtProt for CRY2: NX_Q49AN0

Post-translational modifications:

Phosphorylation on Ser-266 by MAPK is important for the inhibition of CLOCK-ARNTL-mediated transcriptional activity.

Phosphorylation by CSKNE requires interaction with PER1 or PER2¹

Ubiquitinated by the SCF(FBXL3) and SCF(FBXL21) complex, leading to its degradation¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q49AN0

CRY2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001120929.1 NP_066940.2

ENSEMBL proteins:

ENSP00000397419 ENSP00000406751

Reactome Protein details: Q49AN0
Human Recombinant Protein Products for CRY2:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: CRY2 OriGene Protein Over-expression Lysate: CRY2 OriGene Custom Protein Services for CRY2
	GenScript Custom Purified and Recombinant Proteins Services for CRY2
	Novus Biologicals CRY2 Proteins Novus Biologicals CRY2 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CRY2

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IDA	9753616
GO:0005634	nucleus	ISS	--
GO:0005737	cytoplasm	IDA	--
GO:0005739	mitochondrion	--	--

CRY2 for ontologies About GeneDecksing

CRY2 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of CRY2
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	GenScript Custom Superior Antibodies Services for CRY2
	Novus Biologicals CRY2 Antibodies
	Abcam antibodies for CRY2
	Uscn Antibodies for CRY2
	ThermoFisher Antibodies for CRY2

Assay Products for CRY2:

	Browse Kits and Assays available from EMD Millipore
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	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CRY2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CRY2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CRY2 for domains About GeneDecksing

3 InterPro domains/families:

IPR005101 Photolyase_FAD-bd/Cryptochr_C

IPR006050 DNA_photolyase_N

IPR014729 Rossmann-like_a/b/a_fold

Graphical View of Domain Structure for InterPro Entry Q49AN0

ProtoNet protein and cluster: Q49AN0

UniProtKB/Swiss-Prot: CRY2_HUMAN, Q49AN0

Similarity: Belongs to the DNA photolyase class-1 family

Similarity: Contains 1 photolyase/cryptochrome alpha/beta domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CRY2_HUMAN, Q49AN0

Function: Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK NPAS2-ARNTL E box-mediated

transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no

photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May

inhibit CLOCK NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL

Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0000988	protein binding transcription factor activity	IDA	15147242
GO:0003677	DNA binding	IDA	12627958
GO:0003684	damaged DNA binding	IDA	12627958
GO:0003697	single-stranded DNA binding	IDA	12627958

CRY2 for ontologies About GeneDecksing

Phenotypes:
3 GenomeRNAi human phenotypes for CRY2:

Decreased influenza A/WSN/33 r

Increased circadian period len

Synthetic lethal with Ras

13 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Cry2):

adipose tissue	behavior/neurological	cardiovascular system	cellular	growth/size
hematopoietic system	homeostasis/metabolism	immune system	integument	muscle
nervous system	skeleton	vision/eye

CRY2 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for CRY2: Cry2^tm1Jhjh Cry2^tm1Asn

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CRY2

miRNA Products:		OriGene 3'-UTR Clone (see all 2): CRY2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CRY2
		8/61 QIAGEN miScript miRNA Assays for microRNAs that regulate CRY2 (see all 61):
		hsa-miR-194* hsa-miR-142-5p hsa-let-7d hsa-miR-330-5p hsa-miR-106a hsa-miR-513a-5p hsa-miR-1224-3p hsa-miR-519a

		SwitchGear 3'UTR luciferase reporter plasmid: CRY2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CRY2 (see all 7) OriGene shRNA RFP: CRY2 OriGene siRNA: CRY2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CRY2
		Sirion Biotech Custom design and validation of potent shRNA sequences against CRY2

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for CRY2
			Sirion Biotech Customized adenovirus for overexpression of CRY2 Sirion Biotech Customized adenovirus for potent knockdown of CRY2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CRY2 (see all 8) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CRY2 (see all 3) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): CRY2 (NM_021117)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRY2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRY2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CRY2
		Search LifeMap BioReagents cell lines for CRY2
		Sirion Biotech Customized stable knockdown cell line services for CRY2 Sirion Biotech Customized inducible knockdown cell line services for CRY2 Sirion Biotech Customized stable overexpressing cell line services for CRY2 Sirion Biotech Customized inducible overexpressing cell line services for CRY2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRY2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Circadian rhythm - mammal

Circadian rhythm - mammal	1.00	Translocation of CRY:PER:Kinase Ternary Complex into the Nucleus	0.26
Circadian Clock	0.41	Formation of CRY:PER:Kinase Complex	0.26
Circadian Clock in Mammals	0.40	BMAL1:CLOCK/NPAS2 Activates Circadian Expression	0.23

Expression of CRYPTOCHROME-2

Expression of CRYPTOCHROME-2

1.00

Selected targets of ESR1

Selected targets of ESR1

1.00

Diurnally regulated genes with circadian orthologs

Diurnally regulated genes with circadian orthologs

1.00

Signal Transduction

Ubiquitination of CRY Proteins

0.57

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for CRY2

Selected targets of ESR1

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CRY2

	Metabolic States and Circadian Oscillators
	Circadian Clock in Mammals

1 BioSystems Pathway for CRY2

Diurnally regulated genes with circadian orthologs

5/6 Reactome Pathways for CRY2 (see all 6)

	Translocation of CRY:PER:Kinase Ternary Complex into the Nucleus
	Circadian Clock
	Expression of CRYPTOCHROME-2
	Formation of CRY:PER:Kinase Complex
	BMAL1:CLOCK/NPAS2 Activates Circadian Expression

1 Kegg Pathway (Kegg details for CRY2):

Circadian rhythm - mammal

CRY2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CRY2

STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

5/35 Interacting proteins for CRY2 (Q49AN0³ ENSP00000406751⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 35)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PER2	O15055³, ENSP00000254657⁴	I2D: score=4 STRING: ENSP00000254657
CLOCK	O15516³, ENSP00000308741⁴	I2D: score=1 STRING: ENSP00000308741
PER1	O15534³, ENSP00000314420⁴	I2D: score=3 STRING: ENSP00000314420
PER3	P56645³, ENSP00000355031⁴	I2D: score=2 STRING: ENSP00000355031
TIMELESS	Q9UNS1³, ENSP00000229201⁴	I2D: score=3 STRING: ENSP00000229201

About this table

Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IDA	14672706
GO:0000719	NOT photoreactive repair	IDA	12627958
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006606	protein import into nucleus	--	--
GO:0007623	circadian rhythm	--	--

CRY2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CRY2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CRY2

1 HMDB Compound for CRY2 About this table

Compound	Synonyms	CAS #	PubMed Ids
FAD	1H-Purin-6-amine flavin dinucleotide (see all 21)	146-14-5	--

1 Novoseek chemical compound relationship for CRY2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
pterin	74	1	20031915 (1)

Search CenterWatch for drugs/clinical trials and news about CRY2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CRY2 gene (2 alternative transcripts):

NM_001127457.1 NM_021117.3

Unigene Cluster for CRY2:

Cryptochrome 2 (photolyase-like)

Hs.532491 [show with all ESTs]

Unigene Representative Sequence: BC035161

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000417225 ENST00000443527(uc009ykw.3 uc010rgn.2 uc010rgo.2)

ENST00000496571 ENST00000532390 ENST00000473199 ENST00000533779 ENST00000525110

ENST00000495237 ENST00000496667 ENST00000488962

miRNA Products:		OriGene 3'-UTR Clone (see all 2): CRY2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CRY2
		8/61 QIAGEN miScript miRNA Assays for microRNAs that regulate CRY2 (see all 61):
		hsa-miR-194* hsa-miR-142-5p hsa-let-7d hsa-miR-330-5p hsa-miR-106a hsa-miR-513a-5p hsa-miR-1224-3p hsa-miR-519a

		SwitchGear 3'UTR luciferase reporter plasmid: CRY2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CRY2 (see all 7) OriGene shRNA RFP: CRY2 OriGene siRNA: CRY2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CRY2
		Sirion Biotech Custom design and validation of potent shRNA sequences against CRY2

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CRY2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRY2

Additional cDNA sequence:

AB014558.1 AK001194.1 AK291260.1 AK294904.1 AK295627.1 AK302865.1 BC035161.1 BC041814.1

EU219622.1

8 DOTS entries:

DT.416735 DT.91953414 DT.100785151 DT.92428331 DT.120756014 DT.120756030 DT.97859280 DT.95375211

24/204 AceView cDNA sequences (see all 204):

BM719836 AL546483 BQ638765 AI382554 AB014558 BM756433 CB111918 BM739018

BI459617 BM739949 BM739092 BX486701 NM_021117 CB153797 BM756471 BI036117

CB164749 AA317777 Z40383 BC041814 CR621757 BE674510 AL040963 BI821041

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for CRY2 About this scheme

ExUns:	1	^	2	^	3	^	4a	·	4b	·	4c	^	5a	·	5b	^	6	^	7	^	8a	·	8b	^	9	^	10	^	11	^	12	^	13a	·	13b
SP1:																											-
SP2:							-
SP3:							-		-		-
SP4:
SP5:

ECgene alternative splicing isoforms for CRY2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CRY2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGGAAGAGAT

About this image
See CRY2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CRY2

SOURCE GeneReport for Unigene cluster: Hs.532491

UniProtKB/Swiss-Prot: CRY2_HUMAN, Q49AN0

Tissue specificity: Expressed in all tissues examined including fetal brain, fibroblasts, heart, brain, placenta, lung,

liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and

leukocytes. Highest levels in heart and skeletal muscle

SABiosciences Expression via Pathway-Focused PCR Array including CRY2:

Circadian Rhythms in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CRY2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CRY2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CRY2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRY2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRY2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for CRY2 gene from 8/24 species (see all 24) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CRY2¹	cryptochrome 2 (photolyase-like)	78.35(n) 86.6(a)		374092 NM_204244.1 NP_989575.1
lizard (Anolis carolinensis)	Reptilia	CRY2⁶ --	--	85(a) 54(a)	1 ↔ 1 possible ortholog	1(47791489-47827235) 4(132971722-132980431)
African clawed frog (Xenopus laevis)	Amphibia	Xl.12080²	Xenopus laevis cryptochrome 2b mRNA, complete cds	77.63(n)		AY049035.1
zebrafish (Danio rerio)	Actinopterygii	cry3¹	cryptochrome 3	69.27(n) 74.82(a)		83774 NM_131786.2 NP_571861.2
fruit fly (Drosophila melanogaster)	Insecta	phr6-4³	DNA repair DNA (6-4) photolyase	53(a) (best of 2)		2 38D2 --
thale cress (Arabidopsis thaliana)	eudicotyledons	UVR3⁶ ATCRY2⁶ (see all 3)	cryptochrome 2 (see all 3)	44(a) 19(a) (see all 3)	1 ↔ many possible ortholog (see all 3)	3(5293306-5296592) 1(1185550-1188517)
rice (Oryza sativa)	Liliopsida	-- -- (see all 4)	FAD binding domain of DNA photolyase domain contai... FAD binding domain of DNA photolyase domain contai... (see all 4)	43(a) 18(a) (see all 4)	1 ↔ many possible ortholog (see all 4)	2(5835517-5838974) 2(24909993-24916230)
E. coli (Escherichia coli)	Gamma proteobacteria	phr⁶	deoxyribodipyrimidine photolyase, FAD-binding	24(a)	possible ortholog	Chromosome(738730-740148) b0708

ENSEMBL Gene Tree for CRY2 (if available)
TreeFam Gene Tree for CRY2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CRY2 gene

CRY1²

1 SIMAP similar gene for CRY2 using alignment to 4 protein entries: CRY2_HUMAN (see all proteins):

CRY1

CRY2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs111821819^1,2		--	45574085(+)	`AACCAC/ACTCCT`	1	--	us2k¹		1		CSA	2
rs75786694^1,2	C,F	--	45574445(+)	`AGAAAT/CTTCAG`	1	--	us2k¹		1		WA	118
rs11607131^1,2	C,H	--	45574918(+)	`CCCTAC/TCCGGA`	1	--	us2k¹		4		NS EA	374
rs111440493^1,2		--	45575273(+)	`ACAGCG/AGCTTT`	1	--	us2k¹		1		CSA	2
rs78996810^1,2	C,F	--	45576288(+)	`AGCGCG/ATTCGC`	1	--	int¹		1		WA	118
rs11607858^1,2	C,H	--	45576501(+)	`GGCGGA/GACGGG`	1	--	int¹		0	--	--	--	--
rs17725095^1,2	C	--	45576785(+)	`CTCTGG/AAGCTT`	1	--	int¹		3		NA	142
rs7108896^1,2	C,F,H	--	45577149(+)	`CGATGG/AACAGG`	1	--	int¹		5		NS EA WA	478
rs76654788^1,2	C	--	45578098(+)	`GCAACG/CTCCAC`	1	--	int¹		1		WA	2
rs11038688^1,2		--	45578192(+)	`TTTGTA/GTTTTT`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CRY2 (45868669 - 45904799 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for CRY2
5 CNVs: 48805 48808 48807 75633 48806

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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CRY2 for disorders           About GeneDecksing

OMIM gene information: 603732    OMIM disorders: --

18 diseases for CRY2:    About MalaCards

non-hodgkin lymphoma bipolar i disorder hodgkin's lymphoma schizoaffective disorder

chronic myeloid leukemia mood disorder myeloid leukemia bipolar disorder

conjunctivitis hepatocellular carcinoma dementia leukemia

prostate cancer obesity prostatitis schizophrenia

carcinoma alcoholism

1 Novoseek disease relationship for CRY2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cancer	18.5	2	20233903 (1), 20334671 (1)

Human Genome Epidemiology (HuGE) Navigator: CRY2 (28 documents)

Export disorders for CRY2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CRY2 gene, integrated from 9 sources (see all 73):
(articles sorted by number of sources associating them with CRY2)

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Putative human blue-light photoreceptors hCRY1 and hCRY2 are flavoproteins. (PubMed id 8909283)^{1, 2, 3, 9} Hsu D.S.... Sancar A. (1996)
Characterization of photolyase/blue-light receptor homologs in mouse and human cells. (PubMed id 9801304)^{1, 2, 9} Kobayashi K....Yasui A. (1998)
SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins. (PubMed id 17463251)^{1, 2} Busino L....Pagano M. (2007)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Light-independent role of CRY1 and CRY2 in the mammalian circadian clock. (PubMed id 10531061)^{1, 2} Griffin E.A. Jr.... Weitz C.J. (1999)
Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)^{1, 2} Ishikawa K.... Ohara O. (1998)
Phenotypic effects of the circadian gene Cryptochrome 2 on cancer-related pathways. (PubMed id 20334671)^{1, 9} Hoffman A.E....Zhu Y. (2010)
Expression of the blue-light receptor cryptochrome in the human retina. (PubMed id 14507900)^{1, 9} Thompson C.L....Rickman D.W. (2003)
CRY2 is associated with depression. (PubMed id 20195522)^{1, 9} Lavebratt C....Schalling M. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1408	HGNC: 2385	AceView: CRY2	Ensembl:ENSG00000121671	euGenes: HUgn1408
ECgene: CRY2	Kegg: 1408	H-InvDB: CRY2

(According to HUGE)
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HUGE: KIAA0658

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CRY2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CRY2	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/Cryptochrome

Intellectual Property for CRY2 gene
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Patent Information for CRY2 gene:
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cryptochrome 2 (photolyase-like)

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cryptochrome 2 (photolyase-like)

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