Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CRY1 Gene

protein-coding GIFtS: 62
GCID: GC12M107385

cryptochrome 1 (photolyase-like)

(Previous symbol: PHLL1)

Explore 9 diseases affiliated with
CRY1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cryptochrome 1 (Photolyase-Like)¹ ²
PHLL1¹ ² ³ ⁵
Cryptochrome-1¹

External Ids:	HGNC: 2384¹	Entrez Gene: 1407²	Ensembl: ENSG00000008405⁷	OMIM: 601933⁵	UniProtKB: Q16526³

Export aliases for CRY1 gene to outside databases

Previous GC identifers: GC12M106495 GC12M107265 GC12M105887 GC12M104445

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CRY1:

This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core

oscillator complex, which regulates the circadian clock. The encoded protein is widely conserved across plants and

animals. Loss of the related gene in mouse results in a shortened circadian cycle in complete darkness. (provided by

RefSeq, Aug 2012)

UniProtKB/Swiss-Prot: CRY1_HUMAN, Q16526

Function: Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK NPAS2-ARNTL E box-mediated

transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no

photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May

inhibit CLOCK NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL (By

similarity)

Gene Wiki entry for CRY1 (Cryptochrome)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_029419.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CRY1 gene promoter:
E2F-4 E2F-3a E2F-5 Tal-1 Sp1 E2F-2 E2F E2F-1 FOXO1a FOXO1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): CRY1 promoter sequence

Search SABiosciences Chromatin IP Primers for CRY1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CRY1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q23-q24.1 Ensembl cytogenetic band: 12q23.3 HGNC cytogenetic band: 12q23-q24.1

CRY1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRY1 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M107385: view genomic region (about GC identifiers)

Start:	107,385,142 bp from pter	End:	107,487,607 bp from pter
Size:	102,466 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CRY1_HUMAN, Q16526 (See protein sequence)

Recommended Name: Cryptochrome-1

Size: 586 amino acids; 66395 Da

Cofactor: Binds 1 FAD per subunit

Cofactor: Binds 1 5,10-methenyltetrahydrofolate non-covalently per subunit

Subunit: Component of the circadian core oscillator, which includes the CRY proteins, CLOCK or NPAS2, ARNTL or ARNTL2,

CSNK1D and/or CSNK1E, TIMELESS, and the PER proteins. Interacts directly with TIMELESS and the PER proteins. Interacts

directly with PER1 and PER2 C-terminal domains. Interaction with PER2 inhibits its ubiquitination and vice versa.

Binds MAPK. Interacts with FBXL21 (By similarity). Interacts with FBXL3

Subcellular location: Cytoplasm. Nucleus. Note=Translocated to the nucleus through interaction with other Clock

proteins such as PER2 or ARNTL (By similarity)

Explore the universe of human proteins at neXtProt for CRY1: NX_Q16526

Post-translational modifications:

Phosphorylation on Ser-247 by MAPK is important for the inhibition of CLOCK-ARNTL-mediated transcriptional activity.

Phosphorylation by CSNK1E requires interaction with PER1 or PER2. Phosphorylation at Ser-71 and Ser-280 by AMPK

destabilizes it (By similarity)¹

Ubiquitinated by the SCF(FBXL3) and SCF(FBXL21) complex leading to degradation¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q16526

CRY1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_004066.1

ENSEMBL proteins:

ENSP00000008527 ENSP00000447738

Reactome Protein details: Q16526
Human Recombinant Protein Products for CRY1:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: CRY1 OriGene Protein Over-expression Lysate: CRY1 OriGene Custom Protein Services for CRY1
	GenScript Custom Purified and Recombinant Proteins Services for CRY1
	Novus Biologicals CRY1 Protein Novus Biologicals CRY1 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CRY1

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005739	mitochondrion	IEA	--

CRY1 for ontologies About GeneDecksing

CRY1 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for CRY1
	Browse OriGene Antibodies OriGene Custom Antibody Services for CRY1
	GenScript Custom Superior Antibodies Services for CRY1
	Novus Biologicals CRY1 Antibodies
	Abcam antibodies for CRY1
	Uscn Antibodies for CRY1
	ThermoFisher Antibody for CRY1

Assay Products for CRY1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CRY1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CRY1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CRY1 for domains About GeneDecksing

3 InterPro domains/families:

IPR005101 Photolyase_FAD-bd/Cryptochr_C

IPR006050 DNA_photolyase_N

IPR014729 Rossmann-like_a/b/a_fold

Graphical View of Domain Structure for InterPro Entry Q16526

ProtoNet protein and cluster: Q16526

UniProtKB/Swiss-Prot: CRY1_HUMAN, Q16526

Similarity: Belongs to the DNA photolyase class-1 family

Similarity: Contains 1 photolyase/cryptochrome alpha/beta domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CRY1_HUMAN, Q16526

Function: Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK NPAS2-ARNTL E box-mediated

transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no

photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May

inhibit CLOCK NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL (By

similarity)

Induction: Expression is regulated by light and circadian rhythms. Peak expression in the suprachiasma nucleus (SCN)

and eye at the day/night transition (CT12). Levels decrease with ARNTL-CLOCK inhibition as part of the autoregulatory

feedback loop

Genatlas biochemistry entry for CRY1:

cryptochrome 1,photolyase-like,66kDa,putatively involved in photoreactivation,i.e DNA repair by excision of UV induced

DNA damage

Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0000988	protein binding transcription factor activity	IDA	15147242
GO:0003677	DNA binding	TAS	9801304
GO:0003690	double-stranded DNA binding	IDA	9801304
GO:0003904	NOT deoxyribodipyrimidine photo-lyase activity	IDA	8909283

CRY1 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for CRY1:

Synthetic lethal with Ras

13 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Cry1):

adipose tissue	behavior/neurological	cardiovascular system	cellular	growth/size
hematopoietic system	homeostasis/metabolism	immune system	integument	muscle
nervous system	skeleton	vision/eye

CRY1 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Cry1^tm1Jhjh for CRY1

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CRY1

miRNA Products:		OriGene 3'-UTR Clone: CRY1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CRY1
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate CRY1:
		hsa-miR-548d-3p hsa-miR-3658 hsa-miR-3613-3p
		SwitchGear 3'UTR luciferase reporter plasmid: CRY1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CRY1 (see all 7) OriGene shRNA RFP: CRY1 OriGene siRNA: CRY1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CRY1
		Sirion Biotech Custom design and validation of potent shRNA sequences against CRY1

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for CRY1
			Sirion Biotech Customized adenovirus for overexpression of CRY1 Sirion Biotech Customized adenovirus for potent knockdown of CRY1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CRY1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CRY1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CRY1 (NM_004075)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRY1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRY1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CRY1
		Search LifeMap BioReagents cell lines for CRY1
		Sirion Biotech Customized stable knockdown cell line services for CRY1 Sirion Biotech Customized inducible knockdown cell line services for CRY1 Sirion Biotech Customized stable overexpressing cell line services for CRY1 Sirion Biotech Customized inducible overexpressing cell line services for CRY1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRY1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Circadian rhythm - mammal

Circadian rhythm - mammal	1.00	Translocation of CRY:PER:Kinase Ternary Complex into the Nucleus	0.26
Circadian Clock	0.41	Formation of CRY:PER:Kinase Complex	0.26
Circadian Clock in Mammals	0.40	BMAL1:CLOCK/NPAS2 Activates Circadian Expression	0.23

Expression of CRYPTOCHROME-1

Expression of CRYPTOCHROME-1

1.00

Diurnally regulated genes with circadian orthologs

Diurnally regulated genes with circadian orthologs

1.00

Signal Transduction

Ubiquitination of CRY Proteins

0.57

Phosphorylation and Nuclear Translocation of the BMAL1:CLOCK/NPAS2 Heterodimer

Metabolic States and Circadian Oscillators

0.30

Pathway sources
See GeneCards unified pathways
Show all pathways

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CRY1

	Metabolic States and Circadian Oscillators
	Circadian Clock in Mammals

1 BioSystems Pathway for CRY1

Diurnally regulated genes with circadian orthologs

5/6 Reactome Pathways for CRY1 (see all 6)

	Translocation of CRY:PER:Kinase Ternary Complex into the Nucleus
	Circadian Clock
	Expression of CRYPTOCHROME-1
	Formation of CRY:PER:Kinase Complex
	BMAL1:CLOCK/NPAS2 Activates Circadian Expression

1 Kegg Pathway (Kegg details for CRY1):

Circadian rhythm - mammal

CRY1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CRY1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/36 Interacting proteins for CRY1 (Q16526^{2, 3} ENSP00000008527⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 36)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CBLB	Q13191²^,³, ENSP00000264122⁴	MINT-66431 I2D: score=5 STRING: ENSP00000264122
PLSCR1	O15162²^,³, ENSP00000345494⁴	MINT-66152 I2D: score=5 STRING: ENSP00000345494
KRTAP4-12	Q9BQ66²^,³, ENSP00000377582⁴	MINT-66771 I2D: score=5 STRING: ENSP00000377582
MDFI	Q99750²^,³, ENSP00000230321⁴	MINT-66704 I2D: score=5 STRING: ENSP00000230321
PER2	O15055³, ENSP00000254657⁴	I2D: score=4 STRING: ENSP00000254657

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IDA	14672706
GO:0006281	DNA repair	IEA	--
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0007623	circadian rhythm	IEA	--
GO:0009785	blue light signaling pathway	NAS	8909283

CRY1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CRY1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CRY1

1 HMDB Compound for CRY1 About this table

Compound	Synonyms	CAS #	PubMed Ids
FAD	1H-Purin-6-amine flavin dinucleotide (see all 21)	146-14-5	--

1 Novoseek chemical compound relationship for CRY1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
flavin	64	3	20031915 (1)

Search CenterWatch for drugs/clinical trials and news about CRY1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CRY1 gene:

NM_004075.4

Unigene Cluster for CRY1:

Cryptochrome 1 (photolyase-like)

Hs.151573 [show with all ESTs]

Unigene Representative Sequence: NM_004075

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000008527(uc001tmi.3) ENST00000552790 ENST00000549356 ENST00000546722

ENST00000550633

miRNA Products:		OriGene 3'-UTR Clone: CRY1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CRY1
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate CRY1:
		hsa-miR-548d-3p hsa-miR-3658 hsa-miR-3613-3p
		SwitchGear 3'UTR luciferase reporter plasmid: CRY1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CRY1 (see all 7) OriGene shRNA RFP: CRY1 OriGene siRNA: CRY1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CRY1
		Sirion Biotech Custom design and validation of potent shRNA sequences against CRY1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CRY1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CRY1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CRY1 (NM_004075)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRY1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRY1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CRY1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CRY1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CRY1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRY1

Additional cDNA sequence:

AK098615.1 AK131279.1 AK290552.1 BC017466.1 BC030519.1 D83702.1 D84657.1

8 DOTS entries:

DT.453114 DT.91964369 DT.97762832 DT.100840779 DT.100784210 DT.86847446 DT.95371600 DT.95261934

24/115 AceView cDNA sequences (see all 115):

BM472966 BF726475 AK125915 BQ445894 AU133306 BM722246 AA227457 AA885434

CR592420 N24526 AA614046 AI023573 AW173593 AL557156 BM689719 N90516

BG501330 CD244141 BU570202 BU740102 AW243962 AK098615 AI921006 BX453580

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for CRY1 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10a	·	10b	·	10c	^	11	^	12	^	13a	·	13b	^	14a	·	14b
SP1:			-																												-
SP2:																															-
SP3:
SP4:

ECgene alternative splicing isoforms for CRY1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CRY1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTTAAGTTC

About this image
See CRY1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CRY1

SOURCE GeneReport for Unigene cluster: Hs.151573
SABiosciences Expression via Pathway-Focused PCR Arrays including CRY1:

DNA Damage Signaling Pathway in human mouse rat

Circadian Rhythms in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CRY1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CRY1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CRY1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRY1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRY1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for CRY1 gene from 9/27 species (see all 27) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Cry1^{1 , 5}	cryptochrome 1 (photolyase-like)^{1, 5}	89.25(n)¹ 96.59(a)¹		10 (41.63 cM)⁵ 12952¹ NM_007771.3¹ NP_031797.1¹ 85131702⁵
chicken (Gallus gallus)	Aves	CRY1¹	cryptochrome 1 (photolyase-like)	83.05(n) 92.32(a)		374093 NM_204245.1 NP_989576.1
lizard (Anolis carolinensis)	Reptilia	CRY1⁶ --	--	86(a) 56(a)	1 ↔ 1 possible ortholog	5(19455788-19471310) 4(132971722-132980431)
African clawed frog (Xenopus laevis)	Amphibia	cry1-A²	cryptochrome 1 (photolyase-like)	76.84(n)		AY049033.1
zebrafish (Danio rerio)	Actinopterygii	AB042248.1²	--	76.5(n)		83777 AB042248.1
fruit fly (Drosophila melanogaster)	Insecta	phr6-4³	DNA repair DNA (6-4) photolyase	52(a) (best of 2)		2 38D2 --
thale cress (Arabidopsis thaliana)	eudicotyledons	UVR3⁶ ATCRY2⁶ (see all 3)	cryptochrome 2 (see all 3)	45(a) 19(a) (see all 3)	many → 1 possible ortholog (see all 3)	3(5293306-5296592) 1(1185550-1188517)
rice (Oryza sativa)	Liliopsida	-- -- (see all 4)	FAD binding domain of DNA photolyase domain contai... FAD binding domain of DNA photolyase domain contai... (see all 4)	45(a) 18(a) (see all 4)	many → 1 possible ortholog (see all 4)	2(5835517-5838974) 2(24909993-24916230)
E. coli (Escherichia coli)	Gamma proteobacteria	phr⁶	deoxyribodipyrimidine photolyase, FAD-binding	23(a)	possible ortholog	Chromosome(738730-740148)

ENSEMBL Gene Tree for CRY1 (if available)
TreeFam Gene Tree for CRY1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CRY1 gene

CRY2²

1 SIMAP similar gene for CRY1 using alignment to 3 protein entries: CRY1_HUMAN (see all proteins):

CRY2

CRY1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs113281656^1,2		--	107384715(+)	`TGTGGC/ATAACA`	1	--	ds500¹		2		CSA WA	119
rs187118540^1,2		--	107384773(+)	`GAACTA/GTAAAG`	1	--	ds500¹		0	--	--	--	--
rs139958147^1,2		--	107384887(+)	`TGACTC/TGAGAG`	1	--	ds500¹		0	--	--	--	--
rs116069829^1,2	F	--	107384909(+)	`GATTGC/TTAGCC`	1	--	ds500¹		1		WA	118
rs145596506^1,2		--	107384960(+)	`AAAAGG/TCCCTT`	1	--	ds500¹		0	--	--	--	--
rs147717942^1,2		--	107385049(+)	`TGATGC/TGGTTT`	1	--	ds500¹		0	--	--	--	--
rs190074806^1,2		--	107385065(+)	`ATCTCC/TTTGTA`	1	--	ds500¹		0	--	--	--	--
rs182758457^1,2		--	107385113(+)	`TTACCA/CAAAAA`	1	--	ds500¹		0	--	--	--	--
rs76498144^1,2		--	107385126(+)	`AAAAAA/CAACAC`	1	--	ds500¹		0	--	--	--	--
rs75305495^1,2	C	--	107385128(+)	`AAAAAA/CCACGT`	1	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CRY1 (107385142 - 107487607 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CRY1
1 CNV: 101613

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CRY1

DNA2.0 Custom Variant and Variant Library Synthesis for CRY1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CRY1 for disorders           About GeneDecksing

OMIM gene information: 601933    OMIM disorders: --

9 diseases for CRY1:    About MalaCards

chronic lymphocytic leukemia mood disorder lymphocytic leukemia bipolar disorder

conjunctivitis blindness leukemia schizophrenia

prostatitis

Human Genome Epidemiology (HuGE) Navigator: CRY1 (10 documents)

Export disorders for CRY1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CRY1 gene, integrated from 9 sources (see all 60):
(articles sorted by number of sources associating them with CRY1)

Utopia: connect your pdf to the dynamic
world of online information

Cloning, tissue expression, and mapping of a human photolyase homolog with similarity to plant blue-light receptors. (PubMed id 8921389)^{1, 2, 3} van der Spek P.J....Yasui A. (1996)
Putative human blue-light photoreceptors hCRY1 and hCRY2 are flavoproteins. (PubMed id 8909283)^{1, 2, 9} Hsu D.S.... Sancar A. (1996)
SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins. (PubMed id 17463251)^{1, 2} Busino L....Pagano M. (2007)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Light-independent role of CRY1 and CRY2 in the mammalian circadian clock. (PubMed id 10531061)^{1, 2} Griffin E.A. Jr.... Weitz C.J. (1999)
Similarity among the Drosophila (6-4)photolyase, a human photolyase homolog, and the DNA photolyase-blue-light photoreceptor family. (PubMed id 8600518)^{1, 2} Todo T....Ikenaga M. (1996)
Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CL OCK and VIP with bipolar disorder. (PubMed id 20072116)^{1, 9} Soria V....Urretavizcaya M. (2010)
Characterization of photolyase/blue-light receptor homologs in mouse and human cells. (PubMed id 9801304)^{1, 9} Kobayashi K....Yasui A. (1998)
Expression of the blue-light receptor cryptochrome in the human retina. (PubMed id 14507900)^{1, 9} Thompson C.L....Rickman D.W. (2003)
Novel ATP-binding and autophosphorylation activity associated with Arabidopsis and human cryptochrome-1. (PubMed id 12846824)^{1, 9} Bouly J.P....Ahmad M. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 1407	HGNC: 2384	AceView: CRY1	Ensembl:ENSG00000008405	euGenes: HUgn1407
ECgene: CRY1	Kegg: 1407	H-InvDB: CRY1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CRY1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CRY1	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/Cryptochrome

Intellectual Property for CRY1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CRY1 gene:
Search GeneIP for patents involving CRY1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for CRY1 (CRY1)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for CRY1
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CRY1		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CRY1
	OriGene Protein Over-expression Lysate for CRY1		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for CRY1		OriGene 3'-UTR Clone for CRY1
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CRY1		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CRY1
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for CRY1		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for CRY1		OriGene Custom Protein Services for CRY1
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CRY1
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CRY1
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CRY1
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CRY1
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRY1
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CRY1

	GenScript Custom Purified and Recombinant Proteins Services for CRY1		GenScript cDNA clones with any tag delivered in your preferred vector for CRY1
	GenScript Custom Assay Services for CRY1		GenScript Custom Superior Antibodies Services for CRY1
	GenScript Custom overexpressing Cell Line Services for CRY1		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in CRY1 promoter
	Search Chromatin IP Primers for CRY1
	RT² qPCR Primer Assay in human, mouse, rat CRY1
	GNC Network for CRY1
	SABiosciences PCR Arrays including human, mouse, rat CRY1

Search Tocris compounds for CRY1

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	CRY1 antibodies
	CRY1 proteins
	CRY1 lysates

	Antibodies for CRY1
	See all of Abcam's Antibodies, Kits and Proteins for CRY1
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

CRY1 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for CRY1

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRY1

	SwitchGear 3'UTR luciferase reporter plasmids for CRY1
	SwitchGear Promoter luciferase reporter plasmids for CRY1

ThermoFisher Antibody for CRY1

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRY1

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CRY1

Sirion Biotech Customized:

	stable knockdown cell line services for CRY1
	inducible knockdown cell line services for CRY1
	design and validation of potent shRNA sequences against CRY1
	adenovirus for potent knockdown of CRY1
	adenovirus for overexpression of CRY1
	stable overexpressing cell line services for CRY1
	inducible overexpressing cell line services for CRY1

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes CRY1 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

CRY1 Gene

cryptochrome 1 (photolyase-like)

Aliases
for CRY1 gene

Summaries
for CRY1 gene

Genomic Views
for CRY1 gene

Proteins
for CRY1 gene

Protein Domains /
Families
for CRY1 gene

Function
for CRY1 gene

Pathways & Interactions
for CRY1 gene

Drugs & Compounds
for CRY1 gene

Transcripts
for CRY1 gene

Expression
for CRY1 gene

Orthologs
for CRY1 gene

Paralogs
for CRY1 gene

Genomic Variants
for CRY1 gene

Disorders / Diseases
for CRY1 gene

Publications
for CRY1 gene

External Searches for CRY1 gene

Genome Databases showing CRY1 gene

Other Databases showing CRY1 gene

Specialized Databases showing CRY1 gene

Intellectual Property
for CRY1 gene

Products
for CRY1 gene

View Random Gene

Advanced Search

Export list of displayed genes

CRY1 Gene

cryptochrome 1 (photolyase-like)

Aliasesfor CRY1 gene

Summariesfor CRY1 gene

Genomic Viewsfor CRY1 gene

Proteinsfor CRY1 gene

Protein Domains /Familiesfor CRY1 gene

Functionfor CRY1 gene

Pathways & Interactionsfor CRY1 gene

Drugs & Compoundsfor CRY1 gene

Transcriptsfor CRY1 gene

Expression for CRY1 gene

Orthologsfor CRY1 gene

Paralogsfor CRY1 gene

Genomic Variantsfor CRY1 gene

Disorders / Diseasesfor CRY1 gene

Publicationsfor CRY1 gene

External Searches for CRY1 gene

Genome Databases showing CRY1 gene

Other Databases showing CRY1 gene

Specialized Databases showing CRY1 gene

Intellectual Propertyfor CRY1 gene

Productsfor CRY1 gene

View Random Gene

Aliases
for CRY1 gene

Summaries
for CRY1 gene

Genomic Views
for CRY1 gene

Proteins
for CRY1 gene

Protein Domains /
Families
for CRY1 gene

Function
for CRY1 gene

Pathways & Interactions
for CRY1 gene

Drugs & Compounds
for CRY1 gene

Transcripts
for CRY1 gene

Expression
for CRY1 gene

Orthologs
for CRY1 gene

Paralogs
for CRY1 gene

Genomic Variants
for CRY1 gene

Disorders / Diseases
for CRY1 gene

Publications
for CRY1 gene

Intellectual Property
for CRY1 gene

Products
for CRY1 gene