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CRY1 Gene

protein-coding   GIFtS: 65
GCID: GC12M107385

Cryptochrome Circadian Clock 1

(Previous name: cryptochrome 1 (photolyase-like))
(Previous symbol: PHLL1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cryptochrome Circadian Clock 11 2
PHLL11 2 3 5
Cryptochrome 1 (Photolyase-Like)1 2
cryptochrome-12

External Ids:    HGNC: 23841   Entrez Gene: 14072   Ensembl: ENSG000000084057   OMIM: 6019335   UniProtKB: Q165263   

Export aliases for CRY1 gene to outside databases

Previous GC identifers: GC12M106495 GC12M107265 GC12M105887 GC12M104445


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CRY1 Gene:
This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core
oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but
then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL.
Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely
conserved across plants and animals. Loss of the related gene in mouse results in a shortened circadian cycle in
complete darkness. (provided by RefSeq, Jan 2014)

GeneCards Summary for CRY1 Gene:
CRY1 (cryptochrome circadian clock 1) is a protein-coding gene. Diseases associated with CRY1 include sleep disorder, and anxiety disorder. GO annotations related to this gene include double-stranded DNA binding and nucleotide binding. An important paralog of this gene is CRY2.

UniProtKB/Swiss-Prot: CRY1_HUMAN, Q16526
Function: Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK NPAS2-ARNTL E box-mediated
transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no
photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus.
May inhibit CLOCK NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL

Gene Wiki entry for CRY1 (Cryptochrome) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the CRY1 gene promoter:
         E2F-4   E2F-3a   E2F-5   Tal-1   Sp1   E2F-2   E2F   E2F-1   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): CRY1 promoter sequence
   Search Chromatin IP Primers for CRY1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CRY1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q23-q24.1   Ensembl cytogenetic band:  12q23.3   HGNC cytogenetic band: 12q23-q24.1

CRY1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRY1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M107385:  view genomic region     (about GC identifiers)

Start:
107,385,142 bp from pter      End:
107,487,607 bp from pter
Size:
102,466 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CRY1_HUMAN, Q16526 (See protein sequence)
Recommended Name: Cryptochrome-1  
Size: 586 amino acids; 66395 Da
Cofactor: Binds 1 FAD per subunit. Only a minority of the protein molecules contain bound FAD. Contrary to the
situation in photolyases, the FAD is bound in a shallow, surface-exposed pocket
Cofactor: Binds 1 5,10-methenyltetrahydrofolate non-covalently per subunit
Subunit: Component of the circadian core oscillator, which includes the CRY proteins, CLOCK or NPAS2, ARNTL or
ARNTL2, CSNK1D and/or CSNK1E, TIMELESS, and the PER proteins. Interacts directly with TIMELESS and the PER
proteins. Interacts directly with PER1 and PER2 C-terminal domains. Interaction with PER2 inhibits its
ubiquitination and vice versa. Binds MAPK. Interacts with FBXL21 (By similarity). Interacts with FBXL3. Interacts
with PPP5C (via TPR repeats)

Explore the universe of human proteins at neXtProt for CRY1: NX_Q16526

Explore proteomics data for CRY1 at MOPED

Post-translational modifications: 

  • Phosphorylation on Ser-247 by MAPK is important for the inhibition of CLOCK-ARNTL-mediated transcriptional
    activity. Phosphorylation by CSNK1E requires interaction with PER1 or PER2. Phosphorylation at Ser-71 and Ser-280
    by AMPK destabilizes it (By similarity)1
  • Ubiquitinated by the SCF(FBXL3) and SCF(FBXL21) complexes, regulating the balance between degradation and
    stabilization. The SCF(FBXL3) complex is mainly nuclear and mediates ubiquitination and subsequent degradation of
    CRY1. In contrast, cytoplasmic SCF(FBXL21) complex-mediated ubiquitination leads to stabilize CRY1 and counteract
    the activity of the SCF(FBXL3) complex. The SCF(FBXL3) and SCF(FBXL21) complexes probably mediate ubiquitination
    at different Lys residues. Ubiquitination at Lys-11 and Lys-107 are specifically ubiquitinated by the SCF(FBXL21)
    complex but not by the SCF(FBXL3) complex (Probable)1
  • Ubiquitination2 at Lys11, Lys107, Lys159, Lys329, Lys442, Lys485
  • Modification sites at PhosphoSitePlus

  • See CRY1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004066.1  
    ENSEMBL proteins: 
     ENSP00000008527   ENSP00000447738  
    Reactome Protein details: Q16526

    CRY1 Human Recombinant Protein Products:

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    OriGene Purified Protein for CRY1
    OriGene Protein Over-expression Lysate for CRY1
    OriGene MassSpec for CRY1
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    Novus Biologicals CRY1 Protein
    Novus Biologicals CRY1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for CRY1

    CRY1 Antibody Products:

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    R&D Systems Antibodies for CRY1
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    Novus Biologicals CRY1 Antibodies
    Abcam antibodies for CRY1
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    ThermoFisher Antibody for CRY1
    LSBio Antibodies in human, mouse, rat for CRY1

    CRY1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for CRY1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CRY1
    Cloud-Clone Corp. CLIAs for CRY1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR005101 Photolyase_FAD-bd/Cryptochr_C
     IPR006050 DNA_photolyase_N
     IPR014729 Rossmann-like_a/b/a_fold

    Graphical View of Domain Structure for InterPro Entry Q16526

    ProtoNet protein and cluster: Q16526

    UniProtKB/Swiss-Prot: CRY1_HUMAN, Q16526
    Similarity: Belongs to the DNA photolyase class-1 family
    Similarity: Contains 1 photolyase/cryptochrome alpha/beta domain


    CRY1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CRY1_HUMAN, Q16526
    Function: Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK NPAS2-ARNTL E box-mediated
    transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no
    photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus.
    May inhibit CLOCK NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL
    Induction: Expression is regulated by light and circadian rhythms. Peak expression in the suprachiasma nucleus
    (SCN) and eye at the day/night transition (CT12). Levels decrease with ARNTL-CLOCK inhibition as part of the
    autoregulatory feedback loop

         Genatlas biochemistry entry for CRY1:
    cryptochrome 1,photolyase-like,66kDa,putatively involved in photoreactivation,i.e DNA repair by excision of UV
    induced DNA damage

         Gene Ontology (GO): Selected molecular function terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0000989transcription factor binding transcription factor activity IDA15147242
    GO:0001047core promoter binding ISS--
    GO:0003677DNA binding TAS9801304
    GO:0003690double-stranded DNA binding IDA9801304
         
    CRY1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CRY1:
     Synthetic lethal with Ras 

         12 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cry1):
     adipose tissue  behavior/neurological  cardiovascular system  growth/size/body  hematopoietic system 
     homeostasis/metabolism  immune system  integument  muscle  nervous system 
     skeleton  vision/eye 

    CRY1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cry1tm1Jhjh for CRY1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CRY1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CRY1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CRY1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CRY1

    miRNA
    Products:
        
    miRTarBase miRNAs that target CRY1:
    hsa-mir-324-5p (MIRT043195)

    Block miRNA regulation of human, mouse, rat CRY1 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate CRY1:
    hsa-miR-548d-3p hsa-miR-3658 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidCRY1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CRY1
    Predesigned siRNA for gene silencing in human, mouse, rat CRY1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CRY1

    Clone
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    OriGene clones in human, mouse for CRY1 (see all 7)
    OriGene ORF clones in mouse, rat for CRY1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CRY1 (NM_004075)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRY1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRY1

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for CRY1
    Browse ESI BIO Cell Lines and PureStem Progenitors for CRY1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRY1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CRY1_HUMAN, Q16526: Cytoplasm. Nucleus. Note=Translocated to the nucleus through interaction with other Clock
    proteins such as PER2 or ARNTL (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    mitochondrion2
    plasma membrane2
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IEA--

    CRY1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CRY1 About    
    See pathways by source

    SuperPathContained pathways About
    1Circadian rhythm
    Circadian rhythm0.31
    Circadian Clock in Mammals0.31
    2Circadian Clock
    Circadian Clock0.66
    BMAL1-CLOCK/NPAS2 Activates Circadian Expression0.66
    3Metabolic States and Circadian Oscillators
    Metabolic States and Circadian Oscillators
    4Diurnally regulated genes with circadian orthologs
    Diurnally regulated genes with circadian orthologs

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CRY1
        Metabolic States and Circadian Oscillators
    Circadian Clock in Mammals

    1 BioSystems Pathway for CRY1
        Diurnally regulated genes with circadian orthologs

    2 Reactome Pathways for CRY1
        Circadian Clock
    BMAL1:CLOCK,NPAS2 activates circadian gene expression


    1 Kegg Pathway  (Kegg details for CRY1):
        Circadian rhythm


    CRY1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CRY1: 
              DNA Damage Signaling Pathway in human mouse rat
              Circadian Rhythms in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CRY1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CRY1 (Q165262, 3 ENSP000000085274) via UniProtKB, MINT, STRING, and/or I2D (see all 79)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CBLBQ131912, 3, ENSP000002641224MINT-66431 I2D: score=5 STRING: ENSP00000264122
    PLSCR1O151622, 3, ENSP000003454944MINT-66152 I2D: score=5 STRING: ENSP00000345494
    KRTAP4-12Q9BQ662, 3, ENSP000003775824MINT-66771 I2D: score=5 STRING: ENSP00000377582
    MDFIQ997502, 3, ENSP000002303214MINT-66704 I2D: score=5 STRING: ENSP00000230321
    PER2O150553, ENSP000002546574I2D: score=4 STRING: ENSP00000254657
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA12397359
    GO:0006281DNA repair IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0007623circadian rhythm ----
    GO:0009785blue light signaling pathway NAS8909283

    CRY1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CRY1

    1 HMDB Compound for CRY1    About this table
    CompoundSynonyms CAS #PubMed Ids
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--

    1 Novoseek inferred chemical compound relationship for CRY1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    flavin 64 3 20031915 (1)

    1 PharmGKB related drug/compound annotation for CRY1 gene    About this table
    Drug/compound PharmGKB Annotation
    lithiumCA  



    CRY1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CRY1 gene: 
    NM_004075.4  

    Unigene Cluster for CRY1:

    Cryptochrome 1 (photolyase-like)
    Hs.151573  [show with all ESTs]
    Unigene Representative Sequence: NM_004075
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000008527(uc001tmi.3) ENST00000552790 ENST00000549356 ENST00000546722
    ENST00000550633
    miRNA
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    Block miRNA regulation of human, mouse, rat CRY1 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate CRY1:
    hsa-miR-548d-3p hsa-miR-3658 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidCRY1 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: CRY1 (NM_004075)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRY1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRY1
    Primer
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    OriGene qPCR primer pairs and template standards for CRY1
    OriGene qSTAR qPCR primer pairs in human, mouse for CRY1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CRY1
      QuantiTect SYBR Green Assays in human, mouse, rat CRY1
      QuantiFast Probe-based Assays in human, mouse, rat CRY1

    Additional mRNA sequence: 

    AK098615.1 AK131279.1 AK290552.1 BC017466.1 BC030519.1 D83702.1 D84657.1 

    8 DOTS entries:

    DT.453114  DT.91964369  DT.97762832  DT.100840779  DT.100784210  DT.86847446  DT.95371600  DT.95261934 

    Selected AceView cDNA sequences (see all 115):

    AI023573 AU133306 AA227457 BM722246 CR592420 AA614046 AL557156 N24526 
    AA885434 AW173593 AK125915 BF726475 BM472966 BQ445894 BM689719 BQ000307 
    BU742954 AA028913 BX406443 NM_004075 BU740102 D84657 N90516 BX491210 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CRY1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b
    SP1:        -                                                                                   -               
    SP2:                                                                                            -               
    SP3:                                                                                                            
    SP4:                                                                                                            


    ECgene alternative splicing isoforms for CRY1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CRY1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTTAAGTTC
    CRY1 Expression
    About this image


    CRY1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    CRY1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CRY1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.151573
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CRY1: 
              DNA Damage Signaling Pathway in human mouse rat
              Circadian Rhythms in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CRY1
    OriGene qSTAR qPCR primer pairs in human, mouse for CRY1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CRY1
    QuantiTect SYBR Green Assays in human, mouse, rat CRY1
    QuantiFast Probe-based Assays in human, mouse, rat CRY1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRY1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CRY1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cry11 , 5 cryptochrome 1 (photolyase-like)1, 5 89.08(n)1
    96.42(a)1
      10 (41.63 cM)5
    129521  NM_007771.31  NP_031797.11 
     851317025 
    chicken
    (Gallus gallus)
    Aves CRY11 cryptochrome 1 (photolyase-like) 83.11(n)
    92.32(a)
      374093  NM_204245.1  NP_989576.1 
    lizard
    (Anolis carolinensis)
    Reptilia CRY16
    cryptochrome 1 (photolyase-like)
    87(a)
    1 ↔ 1
    5(19436159-19475847)
    African clawed frog
    (Xenopus laevis)
    Amphibia cry1-A2 cryptochrome 1 (photolyase-like) 76.84(n)    AY049033.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AB042248.12   -- 76.5(n)   83777  AB042248.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta phr6-43 DNA repair DNA (6-4) photolyase 52(a)
    (best of 2)
      2 38D2   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PHR16
    DNA photolyase involved in photoreactivation, repa...
    18(a)
    1 → many
    XV(1066839-1068536) YOR386W
    barley
    (Hordeum vulgare)
    Liliopsida Hv.25722 Transcribed sequence with moderate similarity to protein more 72.58(n)    BU968677.1 


    ENSEMBL Gene Tree for CRY1 (if available)
    TreeFam Gene Tree for CRY1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CRY1 gene
    CRY22  
    1 SIMAP similar gene for CRY1 using alignment to 3 protein entries:     CRY1_HUMAN (see all proteins):
    CRY2

    CRY1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CRY1 (see all 2106)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2007147941,2
    Cuntested1107415899(+) GTCCAC/TGAATC 2 H R mis10--------
    rs1132816561,2
    C,F--107384715(+) TGTGGC/ATAACA 1 -- ds50012Minor allele frequency- A:0.04CSA WA 119
    rs1871185401,2
    --107384773(+) GAACTA/GTAAAG 1 -- ds50010--------
    rs1399581471,2
    C--107384887(+) TGACTC/TGAGAG 1 -- ds50010--------
    rs1160698291,2
    F--107384909(+) GATTGC/TTAGCC 1 -- ds50011Minor allele frequency- T:0.02WA 118
    rs1455965061,2
    --107384960(+) AAAAGG/TCCCTT 1 -- ds50010--------
    rs1477179421,2
    --107385049(+) TGATGC/TGGTTT 1 -- ds50010--------
    rs1900748061,2
    --107385065(+) ATCTCC/TTTGTA 1 -- ds50010--------
    rs1827584571,2
    --107385113(+) TTACCA/CAAAAA 1 -- ds50010--------
    rs764981441,2
    --107385126(+) AAAAAA/CAACAC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for CRY1 (107385142 - 107487607 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CRY1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2485513CNV Deletion19546169
    esv1520737CNV Insertion17803354
    esv1001965CNV Insertion20482838

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CRY1
    DNA2.0 Custom Variant and Variant Library Synthesis for CRY1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601933    OMIM disorders: --

    17 diseases for CRY1:    
    About MalaCards
    sleep disorder    anxiety disorder    chronic lymphocytic leukemia    mood disorder
    b-cell chronic lymphocytic leukemia    conjunctivitis    bipolar disorder    blindness
    schizophrenia    tonsillitis    prostatitis    leukemia
    prostate cancer    thyroiditis    malaria    cerebritis
    endotheliitis


    CRY1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CRY1
    Human Genome Epidemiology (HuGE) Navigator: CRY1 (10 documents)

    Export disorders for CRY1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CRY1 gene, integrated from 10 sources (see all 74):
    (articles sorted by number of sources associating them with CRY1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, tissue expression, and mapping of a human photolyase homolog with similarity to plant blue-light receptors. (PubMed id 8921389)1, 2, 3 van der Spek P.J....Yasui A. (Genomics 1996)
    2. Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder. (PubMed id 20072116)1, 4, 9 Soria V....Urretavizcaya M. (Neuropsychopharmacology 2010)
    3. Testing the circadian gene hypothesis in prostate cancer: a population-based case-control study. (PubMed id 19934327)1, 4, 9 Zhu Y....Stanford J.L. (Cancer Res. 2009)
    4. Clock genes may influence bipolar disorder susceptibility and dysfunctional circadian rhythm. (PubMed id 18228528)1, 4, 9 Shi J....Liu C. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008)
    5. Putative human blue-light photoreceptors hCRY1 and hCRY2 are flavoproteins. (PubMed id 8909283)1, 2, 9 Hsu D.S.... Sancar A. (Biochemistry 1996)
    6. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    7. Systematic analysis of circadian genes in a population-based sample reveals association of TIMELESS with depression and sleep disturbance. (PubMed id 20174623)1, 4 Utge S.J....Paunio T. (PLoS ONE 2010)
    8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    9. PER2 variantion is associated with depression vulnerability. (PubMed id 19693801)1, 4 Lavebratt C....Forsell Y. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    10. Response to methadone maintenance treatment is associated with the MYOCD and GRM6 genes. (PubMed id 20560679)1, 4 Fonseca F....Torrens M. (amp 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1407 HGNC: 2384 AceView: CRY1 Ensembl:ENSG00000008405 euGenes: HUgn1407
    ECgene: CRY1 Kegg: 1407 H-InvDB: CRY1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CRY1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CRY1 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Cryptochrome

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CRY1 gene:
    Search GeneIP for patents involving CRY1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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