Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CRTC3 Gene

Aliases for CRTC3 Gene

  • CREB Regulated Transcription Coactivator 3 2 3 5
  • Transducer Of Regulated CAMP Response Element-Binding Protein 3 3 4
  • TORC-3 3 4
  • TORC3 3 4
  • Transducer Of Regulated CAMP Response Element-Binding Protein (CREB) 3 3
  • Transducer Of Regulated CREB Protein 3 3
  • Transducer Of CREB Protein 3 4

External Ids for CRTC3 Gene

Previous GeneCards Identifiers for CRTC3 Gene

  • GC15P088875
  • GC15P091073
  • GC15P067184

Summaries for CRTC3 Gene

Entrez Gene Summary for CRTC3 Gene

  • This gene is a member of the CREB regulated transcription coactivator gene family. This family regulates CREB-dependent gene transcription in a phosphorylation-independent manner and may be selective for cAMP-responsive genes. The protein encoded by this gene may induce mitochondrial biogenesis and attenuate catecholamine signaling in adipose tissue. A translocation event between this gene and Notch coactivator mastermind-like gene 2, which results in a fusion protein, has been reported in mucoepidermoid carcinomas. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]

GeneCards Summary for CRTC3 Gene

CRTC3 (CREB Regulated Transcription Coactivator 3) is a Protein Coding gene. Diseases associated with CRTC3 include Warthin Tumor and Corneal Dystrophy, Posterior Polymorphous, 1. Among its related pathways are HTLV-I infection and Glucose / Energy Metabolism. GO annotations related to this gene include cAMP response element binding protein binding. An important paralog of this gene is CRTC2.

UniProtKB/Swiss-Prot for CRTC3 Gene

  • Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 Ser-133 phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).

Gene Wiki entry for CRTC3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRTC3 Gene

Genomics for CRTC3 Gene

Regulatory Elements for CRTC3 Gene

Enhancers for CRTC3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CRTC3 on UCSC Golden Path with GeneCards custom track

Promoters for CRTC3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CRTC3 on UCSC Golden Path with GeneCards custom track

Genomic Location for CRTC3 Gene

Chromosome:
15
Start:
90,529,886 bp from pter
End:
90,645,345 bp from pter
Size:
115,460 bases
Orientation:
Plus strand

Genomic View for CRTC3 Gene

Genes around CRTC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRTC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRTC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRTC3 Gene

Proteins for CRTC3 Gene

  • Protein details for CRTC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UUV7-CRTC3_HUMAN
    Recommended name:
    CREB-regulated transcription coactivator 3
    Protein Accession:
    Q6UUV7
    Secondary Accessions:
    • Q6DK61
    • Q6DK62
    • Q8NF38
    • Q9H6U2

    Protein attributes for CRTC3 Gene

    Size:
    619 amino acids
    Molecular mass:
    66959 Da
    Quaternary structure:
    • Binding, as a tetramer, through its N-terminal region, with the bZIP domain of CREB1 enhances recruitment of TAF4 to the promoter. Arg-314 in the bZIP domain of CREB1 is essential for this interaction (By similarity). Interaction with HTLV-1 TAX enhances its transcriptional activity. Interacts, via the N-terminal with the ankyrin repeats of BCL3, to form a complex with CREB1 on CRE and TxRE responsive elements and represses HTLV-1 LTR-mediated transcription.
    SequenceCaution:
    • Sequence=BAC03424.1; Type=Frameshift; Positions=82; Evidence={ECO:0000305};

    Alternative splice isoforms for CRTC3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CRTC3 Gene

Proteomics data for CRTC3 Gene at MOPED

Post-translational modifications for CRTC3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CRTC3 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CRTC3 (TORC3)

No data available for DME Specific Peptides for CRTC3 Gene

Domains & Families for CRTC3 Gene

Protein Domains for CRTC3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CRTC3 Gene

Graphical View of Domain Structure for InterPro Entry

Q6UUV7

UniProtKB/Swiss-Prot:

CRTC3_HUMAN :
  • Belongs to the TORC family.
Family:
  • Belongs to the TORC family.
genes like me logo Genes that share domains with CRTC3: view

No data available for Gene Families for CRTC3 Gene

Function for CRTC3 Gene

Molecular function for CRTC3 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 Ser-133 phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).
genes like me logo Genes that share phenotypes with CRTC3: view

Animal Models for CRTC3 Gene

MGI Knock Outs for CRTC3:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CRTC3 Gene

Localization for CRTC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRTC3 Gene

Nucleus. Cytoplasm. Note=Appears to be mainly nuclear. {ECO:0000269 PubMed:15454081}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CRTC3 Gene COMPARTMENTS Subcellular localization image for CRTC3 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for CRTC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA --
genes like me logo Genes that share ontologies with CRTC3: view

Pathways & Interactions for CRTC3 Gene

genes like me logo Genes that share pathways with CRTC3: view

Pathways by source for CRTC3 Gene

1 Cell Signaling Technology pathway for CRTC3 Gene
1 KEGG pathway for CRTC3 Gene

SIGNOR curated interactions for CRTC3 Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for CRTC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0016032 viral process IEA --
GO:0032793 positive regulation of CREB transcription factor activity IEA,IBA --
GO:0042116 macrophage activation IMP 23033494
GO:0043951 negative regulation of cAMP-mediated signaling IEA --
genes like me logo Genes that share ontologies with CRTC3: view

Drugs & Compounds for CRTC3 Gene

(1) Drugs for CRTC3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0
genes like me logo Genes that share compounds with CRTC3: view

Transcripts for CRTC3 Gene

Unigene Clusters for CRTC3 Gene

CREB regulated transcription coactivator 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CRTC3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a ·
SP1: - - - -
SP2:
SP3:
SP4:
SP5: - -
SP6: - - - -
SP7:
SP8:
SP9:

ExUns: 19b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for CRTC3 Gene

GeneLoc Exon Structure for
CRTC3
ECgene alternative splicing isoforms for
CRTC3

Expression for CRTC3 Gene

mRNA expression in normal human tissues for CRTC3 Gene

Protein differential expression in normal tissues from HIPED for CRTC3 Gene

This gene is overexpressed in Testis (24.8), Placenta (11.3), and CD8 Tcells (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CRTC3 Gene



SOURCE GeneReport for Unigene cluster for CRTC3 Gene Hs.567572

mRNA Expression by UniProt/SwissProt for CRTC3 Gene

Q6UUV7-CRTC3_HUMAN
Tissue specificity: Predominantly expressed in B and T lymphocytes. Highest levels in lung. Also expressed in brain, colon, heart, kidney, ovary, and prostate. Weak expression in liver, pancreas, muscle, small intestine, spleen and stomach.
genes like me logo Genes that share expression patterns with CRTC3: view

Protein tissue co-expression partners for CRTC3 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CRTC3 Gene

Orthologs for CRTC3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CRTC3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CRTC3 35
  • 85.13 (n)
  • 89.06 (a)
CRTC3 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CRTC3 35
  • 84.22 (n)
  • 85.58 (a)
CRTC3 36
  • 60 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Crtc3 35
  • 87.24 (n)
  • 88.85 (a)
Crtc3 16
Crtc3 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CRTC3 35
  • 99.57 (n)
  • 99.84 (a)
CRTC3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Crtc3 35
  • 88.19 (n)
  • 89.48 (a)
oppossum
(Monodelphis domestica)
Mammalia CRTC3 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CRTC3 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia crtc3 35
  • 61.32 (n)
  • 56.31 (a)
zebrafish
(Danio rerio)
Actinopterygii crtc3 35
  • 59.46 (n)
  • 54.29 (a)
crtc3 36
  • 48 (a)
OneToOne
Species with no ortholog for CRTC3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CRTC3 Gene

ENSEMBL:
Gene Tree for CRTC3 (if available)
TreeFam:
Gene Tree for CRTC3 (if available)

Paralogs for CRTC3 Gene

Paralogs for CRTC3 Gene

(3) SIMAP similar genes for CRTC3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CRTC3: view

Variants for CRTC3 Gene

Sequence variations from dbSNP and Humsavar for CRTC3 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs8033595 - 90,540,121(+) GAGCA(A/G)TGCGT intron-variant, reference, missense
VAR_038759 -
rs4932347 -- 90,544,140(+) atgaa(C/T)gctct intron-variant
rs4932349 -- 90,579,681(+) CTGTT(A/G)CCCAG intron-variant
rs4932355 -- 90,614,925(+) CGGGC(A/G)TGGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CRTC3 Gene

Variant ID Type Subtype PubMed ID
nsv833088 CNV Loss 17160897
esv33061 CNV Loss 17666407
nsv509582 CNV Insertion 20534489
esv2512119 CNV Deletion 19546169
esv2234796 CNV Deletion 18987734
esv3955 CNV Deletion 18987735
esv1007679 CNV Deletion 20482838
esv2750011 CNV Deletion 23290073
esv1236283 CNV Deletion 17803354
nsv94691 CNV Loss 16902084
esv8010 CNV Loss 19470904
nsv1662 CNV Insertion 18451855

Variation tolerance for CRTC3 Gene

Residual Variation Intolerance Score: 37.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.81; 89.56% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CRTC3 Gene

Disorders for CRTC3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CRTC3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
warthin tumor
  • papillary cystadenoma lymphomatosum
corneal dystrophy, posterior polymorphous, 1
  • posterior polymorphous corneal dystrophy
- elite association - COSMIC cancer census association via MalaCards
Search CRTC3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CRTC3

Genetic Association Database (GAD)
CRTC3
Human Genome Epidemiology (HuGE) Navigator
CRTC3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CRTC3
genes like me logo Genes that share disorders with CRTC3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CRTC3 Gene

Publications for CRTC3 Gene

  1. Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells. (PMID: 14506290) Iourgenko V. … Labow M.A. (Proc. Natl. Acad. Sci. U.S.A. 2003) 2 3 4 67
  2. Enhanced activation of tax-dependent transcription of human T-cell leukemia virus type I (HTLV-I) long terminal repeat by TORC3. (PMID: 15466468) Koga H. … Shimotohno K. (J. Biol. Chem. 2004) 3 23
  3. TORCs: transducers of regulated CREB activity. (PMID: 14536081) Conkright M.D. … Montminy M. (Mol. Cell 2003) 2 3
  4. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for CRTC3 Gene

Sources for CRTC3 Gene

Content