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Aliases for CRTC3 Gene

Aliases for CRTC3 Gene

  • CREB Regulated Transcription Coactivator 3 2 3 5
  • TORC-3 3 4
  • TORC3 3 4
  • Transducer Of Regulated CAMP Response Element-Binding Protein (CREB) 3 3
  • Transducer Of Regulated CAMP Response Element-Binding Protein 3 4
  • CREB-Regulated Transcription Coactivator 3 3
  • Transducer Of Regulated CREB Protein 3 3
  • Transducer Of CREB Protein 3 4

External Ids for CRTC3 Gene

Previous GeneCards Identifiers for CRTC3 Gene

  • GC15P088875
  • GC15P091073
  • GC15P067184

Summaries for CRTC3 Gene

Entrez Gene Summary for CRTC3 Gene

  • This gene is a member of the CREB regulated transcription coactivator gene family. This family regulates CREB-dependent gene transcription in a phosphorylation-independent manner and may be selective for cAMP-responsive genes. The protein encoded by this gene may induce mitochondrial biogenesis and attenuate catecholamine signaling in adipose tissue. A translocation event between this gene and Notch coactivator mastermind-like gene 2, which results in a fusion protein, has been reported in mucoepidermoid carcinomas. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]

GeneCards Summary for CRTC3 Gene

CRTC3 (CREB Regulated Transcription Coactivator 3) is a Protein Coding gene. Diseases associated with CRTC3 include Human T-Cell Leukemia Virus Type 1 and Mucoepidermoid Carcinoma. Among its related pathways are Mitochondrial Gene Expression and HTLV-I infection. GO annotations related to this gene include cAMP response element binding protein binding. An important paralog of this gene is CRTC2.

UniProtKB/Swiss-Prot for CRTC3 Gene

  • Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 Ser-133 phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).

Gene Wiki entry for CRTC3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRTC3 Gene

Genomics for CRTC3 Gene

Regulatory Elements for CRTC3 Gene

Enhancers for CRTC3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15G090556 1.9 FANTOM5 Ensembl ENCODE dbSUPER 21.8 +31.9 31889 11.3 HDGF PKNOX1 ARID4B SIN3A BRCA1 ZNF48 YY1 GATA2 FOS DEK CRTC3 IQGAP1 ENSG00000259212 NIFKP5 ENSG00000270322 ENSG00000200677 FES UNC45A ENSG00000228998 CIB1
GH15G090398 2 FANTOM5 Ensembl ENCODE dbSUPER 16.9 -126.1 -126086 11.2 HDGF FOXA2 PKNOX1 WRNIP1 ARID4B SIN3A FEZF1 ZNF766 FOS JUNB IQGAP1 ZNF774 CRTC3 LOC100631255 RPL36AP43 GABARAPL3 ARPIN ENSG00000259314 CIB1 ZNF710
GH15G090567 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12.5 +40.3 40290 4.4 HDGF PKNOX1 ATF1 ARNT ZNF766 REST TBX21 ZNF592 SMARCA4 STAT3 IQGAP1 CRTC3 ENSG00000200677 FES CIB1 UNC45A GC15M090544
GH15G090647 2 FANTOM5 Ensembl ENCODE dbSUPER 10.9 +119.5 119467 4.7 HDGF PKNOX1 CREB3L1 ARNT YY1 ZNF766 ZNF143 ZNF207 FOS KLF13 BLM CRTC3 ENSG00000200677 ZNF774 GABARAPL3 FES ZNF710 UNC45A GDPGP1 IQGAP1
GH15G090477 1.3 ENCODE dbSUPER 16.1 -50.0 -50037 3.8 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF143 ZNF207 IQGAP1 CRTC3 GABARAPL3 ZNF774 NGRN ENSG00000200677 GC15P090443
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CRTC3 on UCSC Golden Path with GeneCards custom track

Promoters for CRTC3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000081080 514 2001 HDGF ARID4B SIN3A ZNF2 GLIS2 ZNF263 SP3 SMARCB1 ZNF592 SP7

Genomic Location for CRTC3 Gene

Chromosome:
15
Start:
90,529,886 bp from pter
End:
90,645,345 bp from pter
Size:
115,460 bases
Orientation:
Plus strand

Genomic View for CRTC3 Gene

Genes around CRTC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRTC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRTC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRTC3 Gene

Proteins for CRTC3 Gene

  • Protein details for CRTC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UUV7-CRTC3_HUMAN
    Recommended name:
    CREB-regulated transcription coactivator 3
    Protein Accession:
    Q6UUV7
    Secondary Accessions:
    • Q6DK61
    • Q6DK62
    • Q8NF38
    • Q9H6U2

    Protein attributes for CRTC3 Gene

    Size:
    619 amino acids
    Molecular mass:
    66959 Da
    Quaternary structure:
    • Binding, as a tetramer, through its N-terminal region, with the bZIP domain of CREB1 enhances recruitment of TAF4 to the promoter. Arg-314 in the bZIP domain of CREB1 is essential for this interaction (By similarity). Interaction with HTLV-1 TAX enhances its transcriptional activity. Interacts, via the N-terminal with the ankyrin repeats of BCL3, to form a complex with CREB1 on CRE and TxRE responsive elements and represses HTLV-1 LTR-mediated transcription.
    SequenceCaution:
    • Sequence=BAC03424.1; Type=Frameshift; Positions=82; Evidence={ECO:0000305};

    Alternative splice isoforms for CRTC3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CRTC3 Gene

Post-translational modifications for CRTC3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CRTC3 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CRTC3 (TORC3)
  • Santa Cruz Biotechnology (SCBT) Antibodies for CRTC3

No data available for DME Specific Peptides for CRTC3 Gene

Domains & Families for CRTC3 Gene

Protein Domains for CRTC3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CRTC3 Gene

Graphical View of Domain Structure for InterPro Entry

Q6UUV7

UniProtKB/Swiss-Prot:

CRTC3_HUMAN :
  • Belongs to the TORC family.
Family:
  • Belongs to the TORC family.
genes like me logo Genes that share domains with CRTC3: view

No data available for Gene Families for CRTC3 Gene

Function for CRTC3 Gene

Molecular function for CRTC3 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 Ser-133 phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).

Gene Ontology (GO) - Molecular Function for CRTC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008140 cAMP response element binding protein binding IBA --
genes like me logo Genes that share ontologies with CRTC3: view
genes like me logo Genes that share phenotypes with CRTC3: view

Animal Models for CRTC3 Gene

MGI Knock Outs for CRTC3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CRTC3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CRTC3 Gene

Localization for CRTC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRTC3 Gene

Nucleus. Cytoplasm. Note=Appears to be mainly nuclear. {ECO:0000269 PubMed:15454081}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CRTC3 gene
Compartment Confidence
nucleus 5
cytosol 5

Gene Ontology (GO) - Cellular Components for CRTC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA,IBA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with CRTC3: view

Pathways & Interactions for CRTC3 Gene

genes like me logo Genes that share pathways with CRTC3: view

Pathways by source for CRTC3 Gene

1 KEGG pathway for CRTC3 Gene

SIGNOR curated interactions for CRTC3 Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for CRTC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0016032 viral process IEA --
GO:0032793 positive regulation of CREB transcription factor activity IBA,IEA --
GO:0042116 macrophage activation IMP 23033494
genes like me logo Genes that share ontologies with CRTC3: view

Drugs & Compounds for CRTC3 Gene

(1) Drugs for CRTC3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0
genes like me logo Genes that share compounds with CRTC3: view

Transcripts for CRTC3 Gene

Unigene Clusters for CRTC3 Gene

CREB regulated transcription coactivator 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CRTC3

Alternative Splicing Database (ASD) splice patterns (SP) for CRTC3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a ·
SP1: - - - -
SP2:
SP3:
SP4:
SP5: - -
SP6: - - - -
SP7:
SP8:
SP9:

ExUns: 19b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for CRTC3 Gene

GeneLoc Exon Structure for
CRTC3
ECgene alternative splicing isoforms for
CRTC3

Expression for CRTC3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CRTC3 Gene

Protein differential expression in normal tissues from HIPED for CRTC3 Gene

This gene is overexpressed in Testis (24.8), Placenta (11.3), and CD8 Tcells (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CRTC3 Gene



Protein tissue co-expression partners for CRTC3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CRTC3 Gene:

CRTC3

SOURCE GeneReport for Unigene cluster for CRTC3 Gene:

Hs.567572

mRNA Expression by UniProt/SwissProt for CRTC3 Gene:

Q6UUV7-CRTC3_HUMAN
Tissue specificity: Predominantly expressed in B and T lymphocytes. Highest levels in lung. Also expressed in brain, colon, heart, kidney, ovary, and prostate. Weak expression in liver, pancreas, muscle, small intestine, spleen and stomach.

Evidence on tissue expression from TISSUES for CRTC3 Gene

  • Nervous system(4.6)
  • Spleen(4.3)
genes like me logo Genes that share expression patterns with CRTC3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CRTC3 Gene

Orthologs for CRTC3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CRTC3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CRTC3 34 35
  • 99.57 (n)
rat
(Rattus norvegicus)
Mammalia Crtc3 34
  • 88.19 (n)
mouse
(Mus musculus)
Mammalia Crtc3 34 16 35
  • 87.24 (n)
cow
(Bos Taurus)
Mammalia CRTC3 34 35
  • 85.13 (n)
dog
(Canis familiaris)
Mammalia CRTC3 34 35
  • 84.22 (n)
oppossum
(Monodelphis domestica)
Mammalia CRTC3 35
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CRTC3 35
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia crtc3 34
  • 61.32 (n)
zebrafish
(Danio rerio)
Actinopterygii crtc3 34 35
  • 59.46 (n)
Species where no ortholog for CRTC3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CRTC3 Gene

ENSEMBL:
Gene Tree for CRTC3 (if available)
TreeFam:
Gene Tree for CRTC3 (if available)

Paralogs for CRTC3 Gene

Paralogs for CRTC3 Gene

(3) SIMAP similar genes for CRTC3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CRTC3: view

Variants for CRTC3 Gene

Sequence variations from dbSNP and Humsavar for CRTC3 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs193921108 Uncertain significance 90,638,566(+) AGCCC(A/C/G/T)GCGCC intron-variant, reference, missense
rs1000027365 -- 90,600,560(+) CCTGA(C/T)CCACC intron-variant, nc-transcript-variant
rs1000038445 -- 90,535,551(+) TGGCT(C/G)TGAAG intron-variant
rs1000042469 -- 90,573,441(+) GTGGC(C/G)TTAAT intron-variant
rs1000076197 -- 90,595,426(+) AATTA(A/G)CCAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CRTC3 Gene

Variant ID Type Subtype PubMed ID
dgv1259n106 CNV deletion 24896259
esv1007679 CNV deletion 20482838
esv1236283 CNV deletion 17803354
esv2234796 CNV deletion 18987734
esv2512119 CNV deletion 19546169
esv2750011 CNV deletion 23290073
esv3217123 CNV deletion 24192839
esv33061 CNV loss 17666407
esv3552839 CNV deletion 23714750
esv3569875 CNV gain 25503493
esv3955 CNV loss 18987735
esv5649 CNV gain 19470904
esv8010 CNV loss 19470904
nsv1045042 CNV gain 25217958
nsv1069883 CNV deletion 25765185
nsv1078211 CNV insertion 25765185
nsv1127452 CNV deletion 24896259
nsv1142183 CNV tandem duplication 24896259
nsv1148246 CNV deletion 26484159
nsv1662 CNV insertion 18451855
nsv475139 CNV novel sequence insertion 20440878
nsv479235 CNV novel sequence insertion 20440878
nsv509582 CNV insertion 20534489
nsv570396 CNV gain 21841781
nsv833088 CNV loss 17160897
nsv94691 CNV deletion 16902084
nsv957961 CNV deletion 24416366
nsv984108 CNV duplication 23825009

Variation tolerance for CRTC3 Gene

Residual Variation Intolerance Score: 37.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.81; 89.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CRTC3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CRTC3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRTC3 Gene

Disorders for CRTC3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for CRTC3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
human t-cell leukemia virus type 1
  • htlv-1
mucoepidermoid carcinoma
  • mec
warthin tumor
  • adenolymphoma
- elite association - COSMIC cancer census association via MalaCards
Search CRTC3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CRTC3

Genetic Association Database (GAD)
CRTC3
Human Genome Epidemiology (HuGE) Navigator
CRTC3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CRTC3
genes like me logo Genes that share disorders with CRTC3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CRTC3 Gene

Publications for CRTC3 Gene

  1. Enhanced activation of tax-dependent transcription of human T-cell leukemia virus type I (HTLV-I) long terminal repeat by TORC3. (PMID: 15466468) Koga H. … Shimotohno K. (J. Biol. Chem. 2004) 3 4 22 64
  2. Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells. (PMID: 14506290) Iourgenko V. … Labow M.A. (Proc. Natl. Acad. Sci. U.S.A. 2003) 2 3 4 64
  3. TORCs: transducers of regulated CREB activity. (PMID: 14536081) Conkright M.D. … Montminy M. (Mol. Cell 2003) 2 3 4 64
  4. Whole genome association scan for genetic polymorphisms influencing information processing speed. (PMID: 21130836) Luciano M. … Deary I.J. (Biol Psychol 2011) 3 46 64
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64

Products for CRTC3 Gene

  • Addgene plasmids for CRTC3

Sources for CRTC3 Gene

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