Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CRTC3 Gene

Aliases for CRTC3 Gene

  • CREB Regulated Transcription Coactivator 3 2 3
  • TORC3 3 4 6
  • Transducer Of Regulated CAMP Response Element-Binding Protein 3 3 4
  • TORC-3 3 4
  • Transducer Of Regulated CAMP Response Element-Binding Protein (CREB) 3 3
  • CREB-Regulated Transcription Coactivator 3 3
  • Transducer Of Regulated CREB Protein 3 3
  • Transducer Of CREB Protein 3 4

External Ids for CRTC3 Gene

Summaries for CRTC3 Gene

Entrez Gene Summary for CRTC3 Gene

  • This gene is a member of the CREB regulated transcription coactivator gene family. This family regulates CREB-dependent gene transcription in a phosphorylation-independent manner and may be selective for cAMP-responsive genes. The protein encoded by this gene may induce mitochondrial biogenesis and attenuate catecholamine signaling in adipose tissue. A translocation event between this gene and Notch coactivator mastermind-like gene 2, which results in a fusion protein, has been reported in mucoepidermoid carcinomas. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]

GeneCards Summary for CRTC3 Gene

CRTC3 (CREB Regulated Transcription Coactivator 3) is a Protein Coding gene. Diseases associated with CRTC3 include warthin tumor. Among its related pathways are Glucose / Energy Metabolism and HTLV-I infection. GO annotations related to this gene include cAMP response element binding protein binding. An important paralog of this gene is CRTC2.

UniProtKB/Swiss-Prot for CRTC3 Gene

  • Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 Ser-133 phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).

Gene Wiki entry for CRTC3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRTC3 Gene

Genomics for CRTC3 Gene

Genomic Location for CRTC3 Gene

Start:
90,529,886 bp from pter
End:
90,645,345 bp from pter
Size:
115,460 bases
Orientation:
Plus strand

Genomic View for CRTC3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CRTC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRTC3 Gene

Regulatory Elements for CRTC3 Gene

Proteins for CRTC3 Gene

  • Protein details for CRTC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UUV7-CRTC3_HUMAN
    Recommended name:
    CREB-regulated transcription coactivator 3
    Protein Accession:
    Q6UUV7
    Secondary Accessions:
    • Q6DK61
    • Q6DK62
    • Q8NF38
    • Q9H6U2

    Protein attributes for CRTC3 Gene

    Size:
    619 amino acids
    Molecular mass:
    66959 Da
    Quaternary structure:
    • Binding, as a tetramer, through its N-terminal region, with the bZIP domain of CREB1 enhances recruitment of TAF4 to the promoter. Arg-314 in the bZIP domain of CREB1 is essential for this interaction (By similarity). Interaction with HTLV-1 TAX enhances its transcriptional activity. Interacts, via the N-terminal with the ankyrin repeats of BCL3, to form a complex with CREB1 on CRE and TxRE responsive elements and represses HTLV-1 LTR-mediated transcription.
    SequenceCaution:
    • Sequence=BAC03424.1; Type=Frameshift; Positions=82; Evidence={ECO:0000305};

    Alternative splice isoforms for CRTC3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CRTC3 Gene

Proteomics data for CRTC3 Gene at MOPED

Post-translational modifications for CRTC3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CRTC3 Gene

No data available for DME Specific Peptides for CRTC3 Gene

Domains for CRTC3 Gene

Protein Domains for CRTC3 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

CRTC3_HUMAN
Family:
  • Belongs to the TORC family.:
    • Q6UUV7
genes like me logo Genes that share domains with CRTC3: view

No data available for Gene Families for CRTC3 Gene

Function for CRTC3 Gene

Molecular function for CRTC3 Gene

UniProtKB/Swiss-Prot Function: Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 Ser-133 phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).

Gene Ontology (GO) - Molecular Function for CRTC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008140 cAMP response element binding protein binding IBA --
genes like me logo Genes that share ontologies with CRTC3: view
genes like me logo Genes that share phenotypes with CRTC3: view

Animal Models for CRTC3 Gene

MGI Knock Outs for CRTC3:

miRNA for CRTC3 Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CRTC3 Gene

Localization for CRTC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRTC3 Gene

Nucleus. Cytoplasm. Note=Appears to be mainly nuclear.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CRTC3 Gene COMPARTMENTS Subcellular localization image for CRTC3 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for CRTC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with CRTC3: view

Pathways for CRTC3 Gene

genes like me logo Genes that share pathways with CRTC3: view

Pathways by source for CRTC3 Gene

1 Cell Signaling Technology pathway for CRTC3 Gene
1 KEGG pathway for CRTC3 Gene

Gene Ontology (GO) - Biological Process for CRTC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0016032 viral process IEA --
GO:0032793 positive regulation of CREB transcription factor activity IBA --
GO:0042116 macrophage activation IMP 23033494
GO:0043951 negative regulation of cAMP-mediated signaling IEA --
genes like me logo Genes that share ontologies with CRTC3: view

Compounds for CRTC3 Gene

(1) HMDB Compounds for CRTC3 Gene

Compound Synonyms Cas Number PubMed IDs
Cyclic AMP
  • Cyclic AMP
60-92-4
genes like me logo Genes that share compounds with CRTC3: view

Transcripts for CRTC3 Gene

Unigene Clusters for CRTC3 Gene

CREB regulated transcription coactivator 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CRTC3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a ·
SP1: - - - -
SP2:
SP3:
SP4:
SP5: - -
SP6: - - - -
SP7:
SP8:
SP9:

ExUns: 19b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for CRTC3 Gene

GeneLoc Exon Structure for
CRTC3
ECgene alternative splicing isoforms for
CRTC3

Expression for CRTC3 Gene

mRNA expression in normal human tissues for CRTC3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CRTC3 Gene

SOURCE GeneReport for Unigene cluster for CRTC3 Gene Hs.567572

mRNA Expression by UniProt/SwissProt for CRTC3 Gene

Q6UUV7-CRTC3_HUMAN
Tissue specificity: Predominantly expressed in B and T lymphocytes. Highest levels in lung. Also expressed in brain, colon, heart, kidney, ovary, and prostate. Weak expression in liver, pancreas, muscle, small intestine, spleen and stomach.
genes like me logo Genes that share expressions with CRTC3: view

Orthologs for CRTC3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CRTC3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CRTC3 36
  • 99.57 (n)
  • 99.84 (a)
CRTC3 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CRTC3 36
  • 85.13 (n)
  • 89.06 (a)
CRTC3 37
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CRTC3 36
  • 84.22 (n)
  • 85.58 (a)
CRTC3 37
  • 60 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Crtc3 36
  • 87.24 (n)
  • 88.85 (a)
Crtc3 16
Crtc3 37
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CRTC3 37
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CRTC3 37
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Crtc3 36
  • 88.19 (n)
  • 89.48 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia crtc3 36
  • 61.32 (n)
  • 56.31 (a)
zebrafish
(Danio rerio)
Actinopterygii crtc3 36
  • 59.46 (n)
  • 54.29 (a)
crtc3 37
  • 48 (a)
OneToOne
Species with no ortholog for CRTC3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CRTC3 Gene

ENSEMBL:
Gene Tree for CRTC3 (if available)
TreeFam:
Gene Tree for CRTC3 (if available)

Paralogs for CRTC3 Gene

Paralogs for CRTC3 Gene

Selected SIMAP similar genes for CRTC3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CRTC3: view

Variants for CRTC3 Gene

Sequence variations from dbSNP and Humsavar for CRTC3 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs998212 -- 90,561,647(+) ATCTC(C/T)TTAAT intron-variant
rs1104880 -- 90,604,280(+) TGCAG(A/G)GCGAG intron-variant
rs3743406 -- 90,618,316(-) TAAAG(C/T)GCTGG intron-variant
rs3809583 -- 90,616,968(+) ATTTC(A/G)TCGTT intron-variant
rs3862432 -- 90,531,821(+) TATAC(C/T)TATGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CRTC3 Gene

Variant ID Type Subtype PubMed ID
nsv833088 CNV Loss 17160897
esv33061 CNV Loss 17666407
nsv509582 CNV Insertion 20534489
esv2512119 CNV Deletion 19546169
esv2234796 CNV Deletion 18987734
esv3955 CNV Deletion 18987735
esv1007679 CNV Deletion 20482838
esv2750011 CNV Deletion 23290073
esv1236283 CNV Deletion 17803354
nsv94691 CNV Loss 16902084
esv8010 CNV Loss 19470904
nsv1662 CNV Insertion 18451855

Relevant External Links for CRTC3 Gene

HapMap Linkage Disequilibrium report
CRTC3

Disorders for CRTC3 Gene

(1) MalaCards Diseases for CRTC3 Gene

Search for CRTC3 Gene in MalaCards »

(1) University of Copenhagen DISEASES for CRTC3 Gene

Relevant External Links for CRTC3

Genetic Association Database (GAD)
CRTC3
Human Genome Epidemiology (HuGE) Navigator
CRTC3
genes like me logo Genes that share disorders with CRTC3: view

No data available for UniProtKB/Swiss-Prot for CRTC3 Gene

Publications for CRTC3 Gene

  1. Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells. (PMID: 14506290) Iourgenko V. … Labow M.A. (Proc. Natl. Acad. Sci. U.S.A. 2003) 2 3 4
  2. TORCs: transducers of regulated CREB activity. (PMID: 14536081) Conkright M.D. … Montminy M. (Mol. Cell 2003) 2 3 4
  3. Enhanced activation of tax-dependent transcription of human T-cell leukemia virus type I (HTLV-I) long terminal repeat by TORC3. (PMID: 15466468) Koga H. … Shimotohno K. (J. Biol. Chem. 2004) 3 4 23
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  5. Transducer of regulated CREB-binding proteins (TORCs) induce PGC- 1alpha transcription and mitochondrial biogenesis in muscle cells. (PMID: 16980408) Wu Z. … Stevenson S.C. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3 4

Products for CRTC3 Gene

  • Addgene plasmids for CRTC3

Sources for CRTC3 Gene

Back to Top

Content