Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CRTC3 Gene

protein-coding   GIFtS: 58
GCID: GC15P091073

CREB Regulated Transcription Coactivator 3

  See CRTC3-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
CREB Regulated Transcription Coactivator 31 2     CREB-Regulated Transcription Coactivator 32
TORC32 3 5     Transducer Of Regulated CAMP Response Element-Binding Protein (CREB) 32
Transducer Of Regulated CAMP Response Element-Binding Protein 32 3     Transducer Of Regulated CREB Protein 32
TORC-32 3     Transducer Of CREB Protein 33

External Ids:    HGNC: 261481   Entrez Gene: 647842   Ensembl: ENSG000001405777   OMIM: 6089865   UniProtKB: Q6UUV73   

Export aliases for CRTC3 gene to outside databases

Previous GC identifers: GC15P088875 GC15P067184


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for CRTC3 Gene:
This gene is a member of the CREB regulated transcription coactivator gene family. This family regulates
CREB-dependent gene transcription in a phosphorylation-independent manner and may be selective for
cAMP-responsive genes. The protein encoded by this gene may induce mitochondrial biogenesis and attenuate
catecholamine signaling in adipose tissue. A translocation event between this gene and Notch coactivator
mastermind-like gene 2, which results in a fusion protein, has been reported in mucoepidermoid carcinomas.
Alternative splicing results in multiple transcript variants that encode different protein isoforms. (provided by
RefSeq, Jul 2012)

GeneCards Summary for CRTC3 Gene:
CRTC3 (CREB regulated transcription coactivator 3) is a protein-coding gene. Diseases associated with CRTC3 include warthin tumor. GO annotations related to this gene include cAMP response element binding protein binding. An important paralog of this gene is CRTC1.

UniProtKB/Swiss-Prot: CRTC3_HUMAN, Q6UUV7
Function: Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant
cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when
dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1
with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent
coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX
activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR)

Gene Wiki entry for CRTC3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CRTC3 gene promoter:
         AML1a   ATF-2   CREB   CRE-BP1   Nkx6-1   CP2   deltaCREB   Msx-1   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCRTC3 promoter sequence
   Search Chromatin IP Primers for CRTC3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CRTC3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q26.1   Ensembl cytogenetic band:  15q26.1   HGNC cytogenetic band: 15q26.1

CRTC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRTC3 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P091073:  view genomic region     (about GC identifiers)

Start:
91,073,157 bp from pter      End:
91,188,577 bp from pter
Size:
115,421 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CRTC3_HUMAN, Q6UUV7 (See protein sequence)
Recommended Name: CREB-regulated transcription coactivator 3  
Size: 619 amino acids; 66959 Da
Subunit: Binding, as a tetramer, through its N-terminal region, with the bZIP domain of CREB1 enhances recruitment
of TAF4 to the promoter. 'Arg-314' in the bZIP domain of CREB1 is essential for this interaction (By similarity).
Interaction with HTLV-1 TAX enhances its transcriptional activity. Interacts, via the N-terminal with the ankyrin
repeats of BCL3, to form a complex with CREB1 on CRE and TxRE responsive elements and represses HTLV-1
LTR-mediated transcription
Sequence caution: Sequence=BAC03424.1; Type=Frameshift; Positions=82;
Secondary accessions: Q6DK61 Q6DK62 Q8NF38 Q9H6U2
Alternative splicing: 2 isoforms:  Q6UUV7-1   Q6UUV7-3   

Explore the universe of human proteins at neXtProt for CRTC3: NX_Q6UUV7

Explore proteomics data for CRTC3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CRTC3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001036039.1  NP_073606.3  

    ENSEMBL proteins: 
     ENSP00000416573   ENSP00000452640   ENSP00000268184   ENSP00000452676  

    CRTC3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CRTC3
    GenScript Custom Purified and Recombinant Proteins Services for CRTC3
    Novus Biologicals CRTC3 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CRTC3

     
    Search eBioscience for Proteins for CRTC3 

     
    antibodies-online proteins for CRTC3 (3 products) 

     
    Search antibodies-online for peptides for CRTC3

    CRTC3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CRTC3 (TORC3)
    Cell Signaling Technology (CST) Antibodies for CRTC3  (TORC3)
    OriGene Antibodies for CRTC3
    OriGene Custom Antibody Services for CRTC3
    Novus Biologicals CRTC3 Antibodies
    Abcam antibodies for CRTC3
    Cloud-Clone Corp. Antibodies for CRTC3
    ThermoFisher Antibody for CRTC3
    antibodies-online antibodies for CRTC3 (21 products) 

    CRTC3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CRTC3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CRTC3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CRTC3
    Cloud-Clone Corp. CLIAs for CRTC3
    Search eBioscience for ELISAs for CRTC3 
    antibodies-online kits for CRTC3 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    4 InterPro protein domains:
     IPR024786 TORC
     IPR024783 TORC_N
     IPR024784 TORC_M
     IPR024785 TORC_C

    Graphical View of Domain Structure for InterPro Entry Q6UUV7

    ProtoNet protein and cluster: Q6UUV7

    UniProtKB/Swiss-Prot: CRTC3_HUMAN, Q6UUV7
    Similarity: Belongs to the TORC family


    Find genes that share domains with CRTC3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CRTC3_HUMAN, Q6UUV7
    Function: Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant
    cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when
    dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1
    with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent
    coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX
    activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008140cAMP response element binding protein binding IEA--
         
    Find genes that share ontologies with CRTC3           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for CRTC3:
     Decreased p24 protein expressi  Increased S DNA content  Increased cell size 

         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Crtc3):
     adipose tissue  cellular  growth/size/body  homeostasis/metabolism  liver/biliary system 
     muscle 

    Find genes that share phenotypes with CRTC3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Crtc3tm1Mmy for CRTC3

       genOway: Develop your customized and physiologically relevant rodent model for CRTC3

    miRNA
    Products:
        
    miRTarBase miRNAs that target CRTC3:
    hsa-mir-7-5p (MIRT025919), hsa-mir-124-3p (MIRT023199), hsa-mir-671-5p (MIRT039296), hsa-mir-92a-3p (MIRT049715)

    Block miRNA regulation of human, mouse, rat CRTC3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CRTC3 (see all 58):
    hsa-miR-194* hsa-miR-140-5p hsa-miR-300 hsa-miR-1197 hsa-miR-106a hsa-miR-15a hsa-miR-1258 hsa-miR-578
    SwitchGear 3'UTR luciferase reporter plasmidCRTC3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CRTC3
    Predesigned siRNA for gene silencing in human, mouse, rat CRTC3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CRTC3

    Clone
    Products:
         
    OriGene clones in human, mouse for CRTC3 (see all 13)
    OriGene ORF clones in mouse, rat for CRTC3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CRTC3 (NM_022769)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRTC3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRTC3
    Addgene plasmids for CRTC3 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CRTC3
    Browse ESI BIO Cell Lines and PureStem Progenitors for CRTC3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRTC3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    CRTC3_HUMAN, Q6UUV7: Nucleus. Cytoplasm. Note=Appears to be mainly nuclear
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with CRTC3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for CRTC3 About    
    See pathways by source

    SuperPathContained pathways About
    1HTLV-I infection
    HTLV-I infection
    2Glucose / Energy Metabolism
    Glucose / Energy Metabolism


    Find genes that share SuperPaths with CRTC3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for CRTC3
        Glucose / Energy Metabolism


    1 Kegg Pathway  (Kegg details for CRTC3):
        HTLV-I infection

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CRTC3
    Interactions:

        GeneGlobe Interaction Network for CRTC3

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    Selected Interacting proteins for CRTC3 (Q6UUV73 ENSP000002681844) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAGP619813, ENSP000003063304I2D: score=4 STRING: ENSP00000306330
    WNK1Q9H4A33I2D: score=1 
    YWHAEP622583I2D: score=1 
    YWHAZP631043I2D: score=1 
    SIK2ENSP000003059764STRING: ENSP00000305976
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0016032viral process IEA--
    GO:0019048modulation by virus of host morphology or physiology ----
    GO:0032793positive regulation of CREB transcription factor activity IEA--
    GO:0051289protein homotetramerization IEA--

    Find genes that share ontologies with CRTC3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CRTC3

    1 HMDB Compound for CRTC3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for CRTC3 gene (2 alternative transcripts): 
    NM_001042574.2  NM_022769.4  

    Unigene Cluster for CRTC3:

    CREB regulated transcription coactivator 3
    Hs.567572  [show with all ESTs]
    Unigene Representative Sequence: NM_022769
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000420329(uc002bpp.3 uc002bpo.3) ENST00000560098(uc002bpn.3)
    ENST00000561218 ENST00000268184 ENST00000558619 ENST00000560927 ENST00000561119
    ENST00000558005 ENST00000561290 ENST00000558496 ENST00000561255 ENST00000560047
    ENST00000560320 ENST00000558167
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CRTC3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CRTC3 (see all 58):
    hsa-miR-194* hsa-miR-140-5p hsa-miR-300 hsa-miR-1197 hsa-miR-106a hsa-miR-15a hsa-miR-1258 hsa-miR-578
    SwitchGear 3'UTR luciferase reporter plasmidCRTC3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CRTC3
    Predesigned siRNA for gene silencing in human, mouse, rat CRTC3
    Clone
    Products:
         
    OriGene clones in human, mouse for CRTC3 (see all 13)
    OriGene ORF clones in mouse, rat for CRTC3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CRTC3 (NM_022769)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRTC3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRTC3
    Addgene plasmids for CRTC3 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CRTC3
    OriGene qSTAR qPCR primer pairs in human, mouse for CRTC3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CRTC3
      QuantiTect SYBR Green Assays in human, mouse, rat CRTC3
      QuantiFast Probe-based Assays in human, mouse, rat CRTC3

    Additional mRNA sequence: 

    AK024981.1 AK025521.1 AK074170.1 AK090443.1 AK225300.1 AL360259.1 AY360173.1 BC019060.2 
    BC074730.2 BC074731.2 

    11 DOTS entries:

    DT.453027  DT.40234550  DT.95134569  DT.121018996  DT.439611  DT.121019056  DT.121019062  DT.91737590 
    DT.95213901  DT.91716241  DT.91925295 

    Selected AceView cDNA sequences (see all 125):

    CA305883 BE280546 BC074730 BX280445 AA724679 BU168168 NM_022769 AI924877 
    BU528448 BF434743 BM848265 BM784357 BQ637977 BQ720106 AA897770 CA427035 
    CA309358 CD678851 BQ945777 CA391684 AI015510 BM667305 BI260655 AL360259 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CRTC3 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a ·
    SP1:                                -     -     -     -                                                                                                         
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                          -     -                                                                                                                           

    ExUns: 19b
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for CRTC3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    CRTC3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATGGGACCA
    CRTC3 Expression
    About this image

    CRTC3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CRTC3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.567572

    UniProtKB/Swiss-Prot: CRTC3_HUMAN, Q6UUV7
    Tissue specificity: Predominantly expressed in B and T lymphocytes. Highest levels in lung. Also expressed in
    brain, colon, heart, kidney, ovary, and prostate. Weak expression in liver, pancreas, muscle, small intestine,
    spleen and stomach

        Custom PCR Arrays for CRTC3
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CRTC3
    OriGene qSTAR qPCR primer pairs in human, mouse for CRTC3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CRTC3
    QuantiTect SYBR Green Assays in human, mouse, rat CRTC3
    QuantiFast Probe-based Assays in human, mouse, rat CRTC3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRTC3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for CRTC3 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Crtc31 , 5 CREB regulated transcription coactivator 31, 5 87.24(n)1
    88.85(a)1
      7 (45.65 cM)5
    704611  NM_173863.21  NP_776288.21 
     805866275 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia crtc31 CREB regulated transcription coactivator 3 61.32(n)
    56.31(a)
      496857  NM_001078695.1  NP_001072163.1 
    zebrafish
    (Danio rerio)
    Actinopterygii crtc31 CREB regulated transcription coactivator 3 59.46(n)
    54.29(a)
      570024  XM_005166492.1  XP_005166549.1 


    ENSEMBL Gene Tree for CRTC3 (if available)
    TreeFam Gene Tree for CRTC3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for CRTC3 gene
    CRTC12  CRTC22  
    3 SIMAP similar genes for CRTC3 using alignment to 3 protein entries:     CRTC3_HUMAN (see all proteins):
    CRTC3/MAML2 fusion    FLJ00243    CRTC2

    Find genes that share paralogs with CRTC3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for CRTC3 (see all 2656)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1512566221,2
    --91071229(+) GAGCCA/GAGATT 2 -- us2k10--------
    rs1892210351,2
    --91071259(+) TGGGCC/GACAGA 2 -- us2k10--------
    rs1930946111,2
    --91071267(+) AGAGCA/GCGACT 2 -- us2k10--------
    rs359088381,2
    C--91071279(+) GTCTT-/AAAAAA 2 -- us2k10--------
    rs114088371,2
    C--91071280(+) AAAAA-/ACTAGC 2 -- us2k11Minor allele frequency- A:0.50NA 2
    rs284551841,2
    F--91071294(+) AAAAAA/CAACTA 2 -- us2k1 trp34Minor allele frequency- C:0.43NA CSA 7
    rs1456061281,2
    --91071302(+) CTAGCC/TGGGCA 2 -- us2k10--------
    rs1855122591,2
    --91071324(+) GCCTGC/TAATCC 2 -- us2k10--------
    rs1900382871,2
    --91071338(+) TTACTC/TGGGAG 2 -- us2k10--------
    rs58144361,2
    C,F--91071462(+) AAAAA-/AGCATG 2 -- us2k1 trp32Minor allele frequency- A:0.50NA CSA 4

    HapMap Linkage Disequilibrium report for CRTC3 (91073157 - 91188577 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CRTC3 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1007679CNV Deletion20482838
    esv1236283CNV Deletion17803354
    esv2512119CNV Deletion19546169
    esv3955CNV Deletion18987735
    esv2750011CNV Deletion23290073
    esv2234796CNV Deletion18987734
    nsv1662CNV Insertion18451855
    nsv509582CNV Insertion20534489
    esv8010CNV Loss19470904
    nsv94691CNV Loss16902084

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CRTC3
    DNA2.0 Custom Variant and Variant Library Synthesis for CRTC3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 608986    OMIM disorders: --

    1 disease for CRTC3:    
    About MalaCards
    warthin tumor

    1 disease from the University of Copenhagen DISEASES database for CRTC3:
    Mucoepidermoid carcinoma

    Find genes that share disorders with CRTC3           About GenesLikeMe

    Genetic Association Database (GAD): CRTC3
    Human Genome Epidemiology (HuGE) Navigator: CRTC3 (2 documents)

    Export disorders for CRTC3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CRTC3 gene, integrated from 10 sources (see all 42):
    (articles sorted by number of sources associating them with CRTC3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells. (PubMed id 14506290)1, 2, 3 Iourgenko V.... Labow M.A. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    2. TORCs: transducers of regulated CREB activity. (PubMed id 14536081)1, 2, 3 Conkright M.D.... Montminy M. (Mol. Cell 2003)
    3. Enhanced activation of tax-dependent transcription of human T-cell leukemia virus type I (HTLV-I) long terminal repeat by TORC3. (PubMed id 15466468)1, 2, 9 Koga H.... Shimotohno K. (J. Biol. Chem. 2004)
    4. Whole genome association scan for genetic polymorphisms influencing information processing speed. (PubMed id 21130836)1, 4 Luciano M....Deary I.J. (Biol Psychol 2011)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. BCL3 acts as a negative regulator of transcription from the human T- cell leukemia virus type 1 long terminal repeat through interactions with TORC3. (PubMed id 17644518)1, 2 Hishiki T.... Shimotohno K. (J. Biol. Chem. 2007)
    7. Transducer of regulated CREB-binding proteins (TORCs) induce PGC- 1alpha transcription and mitochondrial biogenesis in muscle cells. (PubMed id 16980408)1, 2 Wu Z.... Stevenson S.C. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    8. CRTC1-MAML2 and CRTC3-MAML2 fusions were not detected in metaplastic Warthin tumor and metaplastic pleomorphic adenoma of salivary glands. (PubMed id 24121173)1 SkA!lovA! A....Michal M. (Am. J. Surg. Pathol. 2013)
    9. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    10. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 64784 HGNC: 26148 AceView: TORC3 Ensembl:ENSG00000140577 euGenes: HUgn64784
    ECgene: CRTC3 Kegg: 64784 H-InvDB: CRTC3

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CRTC3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CRTC3 gene:
    Search GeneIP for patents involving CRTC3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for CRTC3 (TORC3)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for CRTC3   OriGene RNAi products in human, mouse, rat for CRTC3  
     OriGene qPCR primer pairs and template standards for CRTC3   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for CRTC3  
     OriGene qSTAR qPCR primer pairs in human, mouse for CRTC3   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for CRTC3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CRTC3   OriGene Custom Protein Services for CRTC3  

     
     
     Block miRNA regulation of human, mouse, rat CRTC3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CRTC3
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CRTC3 Predesigned siRNA for gene silencing in human, mouse, rat CRTC3
     QuantiFast Probe-based Assays in human, mouse, rat CRTC3 QuantiTect SYBR Green Assays in human, mouse, rat CRTC3
     Custom PCR Arrays for CRTC3 Search Chromatin IP Primers for CRTC3
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CRTC3  GeneGlobe Interaction Network for CRTC3
     Regulatory tfbs in CRTC3 promoter
     GenScript Custom Purified and Recombinant Proteins Services for CRTC3 GenScript cDNA clones with any tag delivered in your preferred vector for CRTC3
     GenScript Custom Assay Services for CRTC3 GenScript Custom overexpressing Cell Line Services for CRTC3
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for CRTC3  (TORC3)

     Search Tocris compounds for CRTC3
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CRTC3 antibodies
     CRTC3 proteins
     Antibodies for CRTC3
     See all of Abcam's Antibodies, Kits and Proteins for CRTC3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for CRTC3
     Antibodies for CRTC3
     ELISAs for CRTC3
     CLIAs for CRTC3



     Browse ESI BIO Cell Lines and PureStem Progenitors for CRTC3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRTC3
     SwitchGear 3'UTR luciferase reporter plasmids for CRTC3
     SwitchGear Promoter luciferase reporter plasmids for CRTC3
     ThermoFisher Antibody for CRTC3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRTC3
     Browse compounds at ApexBio
     Addgene plasmids for CRTC3
      Search eBioscience for proteins for CRTC3
      Search eBioscience for elisas for CRTC3
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for CRTC3
     antibodies-online antibodies for CRTC3 (21 products)
     antibodies-online kits for CRTC3 (6 products)
      Search antibodies-online for peptides for CRTC3
     antibodies-online proteins for CRTC3 (3 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CRTC3 gene at Home site.
    Version: 3.12.252 27 Nov 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4