Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CRTC3 Gene

protein-coding   GIFtS: 58
GCID: GC15P091073

CREB Regulated Transcription Coactivator 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
CREB Regulated Transcription Coactivator 31 2     CREB-Regulated Transcription Coactivator 32
TORC32 3 5     Transducer Of Regulated CAMP Response Element-Binding Protein (CREB) 32
Transducer Of Regulated CAMP Response Element-Binding Protein 32 3     Transducer Of Regulated CREB Protein 32
TORC-32 3     Transducer Of CREB Protein 33

External Ids:    HGNC: 261481   Entrez Gene: 647842   Ensembl: ENSG000001405777   OMIM: 6089865   UniProtKB: Q6UUV73   

Export aliases for CRTC3 gene to outside databases

Previous GC identifers: GC15P088875 GC15P067184


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CRTC3 Gene:
This gene is a member of the CREB regulated transcription coactivator gene family. This family regulates
CREB-dependent gene transcription in a phosphorylation-independent manner and may be selective for
cAMP-responsive genes. The protein encoded by this gene may induce mitochondrial biogenesis and attenuate
catecholamine signaling in adipose tissue. A translocation event between this gene and Notch coactivator
mastermind-like gene 2, which results in a fusion protein, has been reported in mucoepidermoid carcinomas.
Alternative splicing results in multiple transcript variants that encode different protein isoforms. (provided by
RefSeq, Jul 2012)

GeneCards Summary for CRTC3 Gene: 
CRTC3 (CREB regulated transcription coactivator 3) is a protein-coding gene. Diseases associated with CRTC3 include mucoepidermoid carcinoma, and human t-cell leukemia virus type 1. GO annotations related to this gene include cAMP response element binding protein binding. An important paralog of this gene is CRTC1.

UniProtKB/Swiss-Prot: CRTC3_HUMAN, Q6UUV7
Function: Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant
cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when
dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1
with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent
coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX
activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR)

Gene Wiki entry for CRTC3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NT_010274.17  NC_018926.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CRTC3 gene promoter:
         AML1a   ATF-2   CREB   CRE-BP1   Nkx6-1   CP2   deltaCREB   Msx-1   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCRTC3 promoter sequence
   Search SABiosciences Chromatin IP Primers for CRTC3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CRTC3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q26.1   Ensembl cytogenetic band:  15q26.1   HGNC cytogenetic band: 15q26.1

CRTC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRTC3 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P091073:  view genomic region     (about GC identifiers)

Start:
91,073,157 bp from pter      End:
91,188,577 bp from pter
Size:
115,421 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CRTC3_HUMAN, Q6UUV7 (See protein sequence)
Recommended Name: CREB-regulated transcription coactivator 3  
Size: 619 amino acids; 66959 Da
Subunit: Binding, as a tetramer, through its N-terminal region, with the bZIP domain of CREB1 enhances recruitment
of TAF4 to the promoter. 'Arg-314' in the bZIP domain of CREB1 is essential for this interaction (By similarity).
Interaction with HTLV-1 TAX enhances its transcriptional activity. Interacts, via the N-terminal with the ankyrin
repeats of BCL3, to form a complex with CREB1 on CRE and TxRE responsive elements and represses HTLV-1
LTR-mediated transcription
Subcellular location: Nucleus. Cytoplasm. Note=Appears to be mainly nuclear
Sequence caution: Sequence=BAC03424.1; Type=Frameshift; Positions=82;
Secondary accessions: Q6DK61 Q6DK62 Q8NF38 Q9H6U2
Alternative splicing: 2 isoforms:  Q6UUV7-1   Q6UUV7-3   

Explore the universe of human proteins at neXtProt for CRTC3: NX_Q6UUV7

Explore proteomics data for CRTC3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6UUV7

  • CRTC3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CRTC3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001036039.1  NP_073606.3  

    ENSEMBL proteins: 
     ENSP00000416573   ENSP00000452640   ENSP00000268184   ENSP00000452676  

    Human Recombinant Protein Products for CRTC3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CRTC3
    GenScript Custom Purified and Recombinant Proteins Services for CRTC3
    Novus Biologicals CRTC3 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CRTC3 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    CRTC3 for ontologies           About GeneDecksing



    CRTC3 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CRTC3 (TORC3)
    Cell Signaling Technology (CST) Antibodies for CRTC3  (TORC3)
    OriGene Antibodies for CRTC3
    OriGene Custom Antibody Services for CRTC3
    GenScript Custom Superior Antibodies Services for CRTC3
    Novus Biologicals CRTC3 Antibodies
    Abcam antibodies for CRTC3
    Cloud-Clone Corp. Antibodies for CRTC3 
    ThermoFisher Antibody for CRTC3
    LSBio Antibodies in human, mouse, rat for CRTC3 

    Assay Products for CRTC3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CRTC3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CRTC3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CRTC3 
    Cloud-Clone Corp. CLIAs for CRTC3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR024786 TORC
     IPR024783 TORC_N
     IPR024784 TORC_M
     IPR024785 TORC_C

    Graphical View of Domain Structure for InterPro Entry Q6UUV7

    ProtoNet protein and cluster: Q6UUV7

    UniProtKB/Swiss-Prot: CRTC3_HUMAN, Q6UUV7
    Similarity: Belongs to the TORC family


    CRTC3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CRTC3_HUMAN, Q6UUV7
    Function: Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant
    cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when
    dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1
    with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent
    coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX
    activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008140cAMP response element binding protein binding IEA--
         
    CRTC3 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for CRTC3:
     Decreased p24 protein expressi  Increased S DNA content  Increased cell size 

         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Crtc3):
     adipose tissue  cellular  growth/size  homeostasis/metabolism  liver/biliary system 
     muscle 

    CRTC3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Crtc3tm1Mmy for CRTC3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CRTC3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CRTC3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CRTC3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CRTC3 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CRTC3
    8/58 QIAGEN miScript miRNA Assays for microRNAs that regulate CRTC3 (see all 58):
    hsa-miR-194* hsa-miR-140-5p hsa-miR-300 hsa-miR-1197 hsa-miR-106a hsa-miR-15a hsa-miR-1258 hsa-miR-578
    SwitchGear 3'UTR luciferase reporter plasmidCRTC3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CRTC3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CRTC3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CRTC3
    Sirion Biotech Customized adenovirus for overexpression of CRTC3

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CRTC3 (see all 10)
    OriGene ORF clones in mouse, rat for CRTC3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CRTC3 (NM_022769)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRTC3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRTC3
    Sirion Biotech Customized lentivirus for stable overexpression of CRTC3 
                         Customized lentivirus expression plasmids for stable overexpression of CRTC3 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CRTC3
    Search LifeMap BioReagents cell lines for CRTC3
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRTC3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CRTC3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Glucose / Energy Metabolism
    Glucose / Energy Metabolism
    2HTLV-I infection
    HTLV-I infection

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for CRTC3
        Glucose / Energy Metabolism


    1         Kegg Pathway  (Kegg details for CRTC3):
        HTLV-I infection


    CRTC3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CRTC3

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/7 Interacting proteins for CRTC3 (Q6UUV73 ENSP000002681844) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAGP619813, ENSP000003063304I2D: score=4 STRING: ENSP00000306330
    WNK1Q9H4A33I2D: score=1 
    YWHAEP622583I2D: score=1 
    YWHAZP631043I2D: score=1 
    SIK2ENSP000003059764STRING: ENSP00000305976
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0019048modulation by virus of host morphology or physiology IEA--
    GO:0032793positive regulation of CREB transcription factor activity IEA--
    GO:0051289protein homotetramerization IEA--

    CRTC3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CRTC3

    1 HMDB Compound for CRTC3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--

    Search CenterWatch for drugs/clinical trials and news about CRTC3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CRTC3 gene (2 alternative transcripts): 
    NM_001042574.2  NM_022769.4  

    Unigene Cluster for CRTC3:

    CREB regulated transcription coactivator 3
    Hs.567572  [show with all ESTs]
    Unigene Representative Sequence: NM_022769
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000420329(uc002bpp.3 uc002bpo.3) ENST00000560098(uc002bpn.3)
    ENST00000561218 ENST00000268184 ENST00000558619 ENST00000560927 ENST00000561119
    ENST00000558005 ENST00000561290 ENST00000558496 ENST00000561255 ENST00000560047
    ENST00000560320 ENST00000558167
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CRTC3
    8/58 QIAGEN miScript miRNA Assays for microRNAs that regulate CRTC3 (see all 58):
    hsa-miR-194* hsa-miR-140-5p hsa-miR-300 hsa-miR-1197 hsa-miR-106a hsa-miR-15a hsa-miR-1258 hsa-miR-578
    SwitchGear 3'UTR luciferase reporter plasmidCRTC3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CRTC3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CRTC3
    Clone
    Products:
         
    OriGene clones in human, mouse for CRTC3 (see all 10)
    OriGene ORF clones in mouse, rat for CRTC3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CRTC3 (NM_022769)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRTC3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRTC3
    Sirion Biotech Customized lentivirus for stable overexpression of CRTC3 
                         Customized lentivirus expression plasmids for stable overexpression of CRTC3 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CRTC3
    OriGene qSTAR qPCR primer pairs in human, mouse for CRTC3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CRTC3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CRTC3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRTC3

    Additional mRNA sequence: 

    AK024981.1 AK025521.1 AK074170.1 AK090443.1 AK225300.1 AL360259.1 AY360173.1 BC019060.2 
    BC074730.2 BC074731.2 

    11 DOTS entries:

    DT.453027  DT.40234550  DT.95134569  DT.121018996  DT.439611  DT.121019056  DT.121019062  DT.91737590 
    DT.95213901  DT.91716241  DT.91925295 

    24/125 AceView cDNA sequences (see all 125):

    BQ068919 BM698139 BQ945777 CD678851 BC019060 CA427035 CA309358 AA897770 
    AI573132 BF593236 BQ720106 BU507559 AK074170 AI924877 BF512967 AL360259 
    CA391684 CA305883 AK025521 BM848265 BX493097 BF434743 BX280445 BC074731 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for CRTC3 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a ·
    SP1:                                -     -     -     -                                                                                                         
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                          -     -                                                                                                                           

    ExUns: 19b
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for CRTC3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CRTC3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATGGGACCA
    CRTC3 Expression
    About this image


    See CRTC3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CRTC3

    SOURCE GeneReport for Unigene cluster: Hs.567572

    UniProtKB/Swiss-Prot: CRTC3_HUMAN, Q6UUV7
    Tissue specificity: Predominantly expressed in B and T lymphocytes. Highest levels in lung. Also expressed in
    brain, colon, heart, kidney, ovary, and prostate. Weak expression in liver, pancreas, muscle, small intestine,
    spleen and stomach

        SABiosciences Custom PCR Arrays for CRTC3
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CRTC3
    OriGene qSTAR qPCR primer pairs in human, mouse for CRTC3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CRTC3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CRTC3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRTC3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRTC3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CRTC3 gene from 2/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Crtc31 , 5 CREB regulated transcription coactivator 31, 5 87.24(n)1
    88.85(a)1
      7 (45.65 cM)5
    704611  NM_173863.21  NP_776288.21 
     805866275 
    zebrafish
    (Danio rerio)
    Actinopterygii CR382298.26
    Uncharacterized protein
    44(a)
    1 ↔ 1
    7(52005062-52088616)


    ENSEMBL Gene Tree for CRTC3 (if available)
    TreeFam Gene Tree for CRTC3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CRTC3 gene
    CRTC12  CRTC22  
    3 SIMAP similar genes for CRTC3 using alignment to 3 protein entries:     CRTC3_HUMAN (see all proteins):
    CRTC3/MAML2 fusion    FLJ00243    CRTC2

    CRTC3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2656 SNPs in CRTC3 are shown (see all 2656)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0387594
    ----see VAR_0387592 L S mis40--------
    rs1512566221,2
    --91071229(+) GAGCCA/GAGATT 2 -- us2k10--------
    rs1892210351,2
    --91071259(+) TGGGCC/GACAGA 2 -- us2k10--------
    rs1930946111,2
    --91071267(+) AGAGCA/GCGACT 2 -- us2k10--------
    rs359088381,2
    C--91071279(+) GTCTT-/AAAAAA 2 -- us2k10--------
    rs114088371,2
    C--91071280(+) AAAAA-/ACTAGC 2 -- us2k11Minor allele frequency- A:0.50NA 2
    rs284551841,2
    F--91071294(+) AAAAAA/CAACTA 2 -- us2k1 trp34Minor allele frequency- C:0.43NA CSA 7
    rs1456061281,2
    --91071302(+) CTAGCC/TGGGCA 2 -- us2k10--------
    rs1855122591,2
    --91071324(+) GCCTGC/TAATCC 2 -- us2k10--------
    rs1900382871,2
    --91071338(+) TTACTC/TGGGAG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for CRTC3 (91073157 - 91188577 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/12 variations for CRTC3 (see all 12):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1007679CNV Deletion20482838
    esv1236283CNV Deletion17803354
    esv2512119CNV Deletion19546169
    esv3955CNV Deletion18987735
    esv2750011CNV Deletion23290073
    esv2234796CNV Deletion18987734
    nsv1662CNV Insertion18451855
    nsv509582CNV Insertion20534489
    esv8010CNV Loss19470904
    nsv94691CNV Loss16902084

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CRTC3
    DNA2.0 Custom Variant and Variant Library Synthesis for CRTC3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608986    OMIM disorders: --

    5 diseases for CRTC3:    About MalaCards
    mucoepidermoid carcinoma    human t-cell leukemia virus type 1    t-cell leukemia    leukemia
    prostatitis

    1 disease from the University of Copenhagen DISEASES database for CRTC3:
    Mucoepidermoid carcinoma

    CRTC3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CRTC3
    Human Genome Epidemiology (HuGE) Navigator: CRTC3 (2 documents)

    Export disorders for CRTC3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CRTC3 gene, integrated from 9 sources (see all 39):
    (articles sorted by number of sources associating them with CRTC3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells. (PubMed id 14506290)1, 2, 3 Iourgenko V.... Labow M.A. (2003)
    2. TORCs: transducers of regulated CREB activity. (PubMed id 14536081)1, 2, 3 Conkright M.D.... Montminy M. (2003)
    3. Enhanced activation of tax-dependent transcription of human T-cell leukemia virus type I (HTLV-I) long terminal repeat by TORC3. (PubMed id 15466468)1, 2, 9 Koga H.... Shimotohno K. (2004)
    4. Whole genome association scan for genetic polymorphis ms influencing information processing speed. (PubMed id 21130836)1, 4 Luciano M....Deary I.J. (2011)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    6. BCL3 acts as a negative regulator of transcription from the human T- cell leukemia virus type 1 long terminal repeat through interactions with TORC3. (PubMed id 17644518)1, 2 Hishiki T.... Shimotohno K. (2007)
    7. Transducer of regulated CREB-binding proteins (TORCs) induce PGC- 1alpha transcription and mitochondrial biogenesis in muscle cells. (PubMed id 16980408)1, 2 Wu Z.... Stevenson S.C. (2006)
    8. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    9. Host-microbe interactions have shaped the genetic arch itecture of inflammatory bowel disease. (PubMed id 23128233)1 Jostins L....Cho J.H. (2012)
    10. Role of cAMP-responsive element-binding protein (CREB )-regulated transcription coactivator 3 (CRTC3) in the initiation of mitochondr ial biogenesis and stress response in liver cells. (PubMed id 21536665)1 Than T.A....Kaplowitz N. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 64784 HGNC: 26148 AceView: TORC3 Ensembl:ENSG00000140577 euGenes: HUgn64784
    ECgene: CRTC3 Kegg: 64784 H-InvDB: CRTC3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CRTC3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CRTC3 gene:
    Search GeneIP for patents involving CRTC3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for CRTC3 (TORC3)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for CRTC3   OriGene RNAi products in human, mouse, rat for CRTC3  
     OriGene qPCR primer pairs and template standards for CRTC3   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for CRTC3  
     OriGene qSTAR qPCR primer pairs in human, mouse for CRTC3   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for CRTC3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CRTC3   OriGene Custom Protein Services for CRTC3  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CRTC3
     QIAGEN SeqTarget long-range PCR primers for resequencing CRTC3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CRTC3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CRTC3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRTC3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CRTC3
     GenScript Custom Purified and Recombinant Proteins Services for CRTC3 GenScript cDNA clones with any tag delivered in your preferred vector for CRTC3
     GenScript Custom Assay Services for CRTC3 GenScript Custom Superior Antibodies Services for CRTC3
     GenScript Custom overexpressing Cell Line Services for CRTC3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for CRTC3  (TORC3)

     Regulatory tfbs in CRTC3 promoter
     Search Chromatin IP Primers for CRTC3
     RT2 qPCR Primer Assay in human, mouse, rat CRTC3
     GNC Network for CRTC3
     SABiosciences Custom PCR Arrays for CRTC3
     Search Tocris compounds for CRTC3
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CRTC3 antibodies
     CRTC3 proteins
     Antibodies for CRTC3
     See all of Abcam's Antibodies, Kits and Proteins for CRTC3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for CRTC3
     Antibodies for CRTC3
     ELISAs for CRTC3
     CLIAs for CRTC3
     Search LifeMap BioReagents cell lines for CRTC3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRTC3
     SwitchGear 3'UTR luciferase reporter plasmids for CRTC3
     SwitchGear Promoter luciferase reporter plasmids for CRTC3
     ThermoFisher Antibody for CRTC3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRTC3
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CRTC3
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CRTC3
    Customized:
     lentivirus for stable overexpression of CRTC3
     lentivirus expression plasmids for stable overexpression of CRTC3
     adenovirus for overexpression of CRTC3
     LSBio Antibodies in human, mouse, rat for CRTC3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CRTC3 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4