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CRTC2 Gene

protein-coding   GIFtS: 62
GCID: GC01M153920

CREB Regulated Transcription Coactivator 2

Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CREB Regulated Transcription Coactivator 21 2     Transducer Of Regulated CAMP Response Element-Binding Protein (CREB) 22
TORC22 3 5     Transducer Of CREB Protein 23
TORC-22 3     Transducer Of Regulated CAMP Response Element-Binding Protein 23
CREB-Regulated Transcription Coactivator 22     

External Ids:    HGNC: 273011   Entrez Gene: 2001862   Ensembl: ENSG000001607417   OMIM: 6089725   UniProtKB: Q53ET03   

Export aliases for CRTC2 gene to outside databases

Previous GC identifers: GC01M150734 GC01M152186 GC01M125282


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CRTC2 Gene:
This gene encodes a member of the transducers of regulated cAMP response element-binding protein activity family
of transcription coactivators. These proteins promote the transcription of genes targeted by the cAMP response
element-binding protein, and therefore play an important role in many cellular processes. Under basal conditions
the encoded protein is phosphorylated by AMP-activated protein kinase or the salt-inducible kinases and is
sequestered in the cytoplasm. Upon activation by elevated cAMP or calcium, the encoded protein translocates to
the nucleus and increases target gene expression. Single nucleotide polymorphisms in this gene may increase the
risk of type 2 diabetes. A pseudogene of this gene is located on the long arm of chromosome 5. (provided by
RefSeq, Dec 2010)

GeneCards Summary for CRTC2 Gene:
CRTC2 (CREB regulated transcription coactivator 2) is a protein-coding gene. Diseases associated with CRTC2 include human t-cell leukemia virus type 1, and mucoepidermoid carcinoma. GO annotations related to this gene include cAMP response element binding protein binding. An important paralog of this gene is CRTC3.

UniProtKB/Swiss-Prot: CRTC2_HUMAN, Q53ET0
Function: Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant
cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when
dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1
with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the
expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of
mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus
type 1 (HTLV-1) long terminal repeats (LTR)

Gene Wiki entry for CRTC2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CRTC2 gene promoter:
         STAT5A   Tal-1beta   CREB   PPAR-gamma1   POU2F1   deltaCREB   PPAR-gamma2   ITF-2   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCRTC2 promoter sequence
   Search Chromatin IP Primers for CRTC2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CRTC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.3   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21.3

CRTC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRTC2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M153920:  view genomic region     (about GC identifiers)

Start:
153,920,145 bp from pter      End:
153,931,132 bp from pter
Size:
10,988 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CRTC2_HUMAN, Q53ET0 (See protein sequence)
Recommended Name: CREB-regulated transcription coactivator 2  
Size: 693 amino acids; 73302 Da
Subunit: Binds, as a tetramer, through its N-terminal region, with the bZIP domain of CREB1. 'Arg-314' in the bZIP
domain of CREB1 is essential for this interaction. Interaction, via its C-terminal, with TAF4, enhances
recruitment of TAF4 to CREB1 (By similarity). Interacts with PPP3CA/calcineurin alpha, SIK2 and 14-3-3 proteins,
YWHAB and YWHAG. Interaction with the human T-cell leukemia virus type 1 (HTLV-1) Tax protein is essential for
optimal transcription activation by Tax. Interaction with RFWD2/COP1 mediates nuclear export and degradation of
CRTC2 (By similarity)
1 PDB 3D structure from and Proteopedia for CRTC2:
4HTM (3D)    
Secondary accessions: Q6UUV8 Q7Z3X7

Explore the universe of human proteins at neXtProt for CRTC2: NX_Q53ET0

Explore proteomics data for CRTC2 at MOPED

Post-translational modifications: 

  • Phosphorylation/dephosphorylation states of Ser-171 are required for regulating transduction of CREB activity.
    TORCs are inactive when phosphorylated, and active when dephosphorylated at this site. This primary site of
    phosphorylation, is regulated by cAMP and calcium levels and is dependent on the phosphorylation of SIKs (SIK1
    and SIK2) by LKB1. Both insulin and AMPK increase this phosphorylation of CRTC2 while glucagon suppresses it.
    Phosphorylation at Ser-274 by MARK2 is induced under low glucose conditions and dephosphorylated in response to
    glucose influx. Phosphorylation at Ser-274 promotes interaction with 14-3-3 proteins and translocation to the
    cytoplasm1
  • Ubiquitination2 at Lys156
  • Modification sites at PhosphoSitePlus

  • See CRTC2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_859066.1  
    ENSEMBL proteins: 
     ENSP00000305873   ENSP00000434115   ENSP00000357619   ENSP00000357622  

    CRTC2 Human Recombinant Protein Products:

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    Novus Biologicals CRTC2 Proteins
    Novus Biologicals CRTC2 Lysate
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CRTC2

    CRTC2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CRTC2
    R&D Systems Antibodies for CRTC2 (TORC2)
    Cell Signaling Technology (CST) Antibodies for CRTC2  (TORC2)
    OriGene Antibodies for CRTC2
    OriGene Custom Antibody Services for CRTC2
    Novus Biologicals CRTC2 Antibodies
    Abcam antibodies for CRTC2
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    ThermoFisher Antibody for CRTC2
    LSBio Antibodies in human, mouse, rat for CRTC2

    CRTC2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CRTC2
    Cloud-Clone Corp. CLIAs for CRTC2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR024786 TORC
     IPR024783 TORC_N
     IPR024784 TORC_M
     IPR024785 TORC_C

    Graphical View of Domain Structure for InterPro Entry Q53ET0

    ProtoNet protein and cluster: Q53ET0

    UniProtKB/Swiss-Prot: CRTC2_HUMAN, Q53ET0
    Similarity: Belongs to the TORC family


    CRTC2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CRTC2_HUMAN, Q53ET0
    Function: Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant
    cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when
    dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1
    with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the
    expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of
    mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus
    type 1 (HTLV-1) long terminal repeats (LTR)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008140cAMP response element binding protein binding IEA--
         
    CRTC2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CRTC2:
     Decreased p24 protein expressi 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Crtc2):
     homeostasis/metabolism  liver/biliary system  no phenotypic analysis 

    CRTC2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Crtc2tm1.1Khk for CRTC2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CRTC2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CRTC2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CRTC2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CRTC2

    miRNA
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    miRTarBase miRNAs that target CRTC2:
    hsa-mir-92a-3p (MIRT049460)

    Block miRNA regulation of human, mouse, rat CRTC2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CRTC2 (see all 31):
    hsa-miR-623 hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-185* hsa-miR-374a hsa-miR-302e hsa-miR-520a-3p
    SwitchGear 3'UTR luciferase reporter plasmidCRTC2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CRTC2
    Predesigned siRNA for gene silencing in human, mouse, rat CRTC2

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for CRTC2

    Clone
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    OriGene clones in human, mouse for CRTC2 (see all 6)
    OriGene ORF clones in mouse, rat for CRTC2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CRTC2 (NM_181715)
    Sino Biological Human cDNA Clone for CRTC2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRTC2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRTC2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CRTC2 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRTC2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CRTC2_HUMAN, Q53ET0: Cytoplasm. Nucleus. Note=Translocated from the nucleus to the cytoplasm on interaction of
    the phosphorylated form with 14-3-3 protein. In response to cAMP levels and glucagon, relocated to the nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    mitochondrion1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm ISS--
    GO:0070062extracellular vesicular exosome IDA19056867

    CRTC2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CRTC2 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1PI3K-Akt signaling pathway
    PI3K-Akt signaling pathway
    2Metformin Pathway, Pharmacodynamic
    Metformin Pathway, Pharmacodynamic
    3LKB1 signaling events
    LKB1 signaling events
    4HTLV-I infection
    HTLV-I infection
    5Glucose / Energy Metabolism
    Glucose / Energy Metabolism

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for CRTC2
        Glucose / Energy Metabolism

    2 BioSystems Pathways for CRTC2
        AMPK signaling
    LKB1 signaling events


    1 PharmGKB Pathway for CRTC2
        Metformin Pathway, Pharmacodynamic

    2 Kegg Pathways  (Kegg details for CRTC2):
        PI3K-Akt signaling pathway
    HTLV-I infection


    CRTC2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CRTC2
    Interactions:

        GeneGlobe Interaction Network for CRTC2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for CRTC2 (Q53ET01, 2, 3 ENSP000003058734) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H3BP684313, ENSP000002446614I2D: score=1 STRING: ENSP00000244661
    HIST1H3AP684313I2D: score=1 
    HIST1H3CP684313I2D: score=1 
    HIST1H3DP684313I2D: score=1 
    HIST1H3EP684313I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006094gluconeogenesis ISS--
    GO:0006351transcription, DNA-templated IEA--
    GO:0016032viral process IEA--
    GO:0019048modulation by virus of host morphology or physiology ----
    GO:0032793positive regulation of CREB transcription factor activity ISS--

    CRTC2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CRTC2

    2 HMDB Compounds for CRTC2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Cyclic AMPCyclic AMP (see all 19)60-92-4--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CRTC2 gene: 
    NM_181715.2  

    Unigene Cluster for CRTC2:

    CREB regulated transcription coactivator 2
    Hs.406392  [show with all ESTs]
    Unigene Representative Sequence: NM_181715
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000303569 ENST00000461638(uc001fde.4) ENST00000368630 ENST00000368633(uc021pab.1)
    ENST00000487235(uc001fdf.4) ENST00000524997 ENST00000467860 ENST00000493909
    ENST00000476883 ENST00000492073
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Block miRNA regulation of human, mouse, rat CRTC2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CRTC2 (see all 31):
    hsa-miR-623 hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-185* hsa-miR-374a hsa-miR-302e hsa-miR-520a-3p
    SwitchGear 3'UTR luciferase reporter plasmidCRTC2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CRTC2
    Clone
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    OriGene ORF clones in mouse, rat for CRTC2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CRTC2 (NM_181715)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRTC2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRTC2
    Primer
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    OriGene qPCR primer pairs and template standards for CRTC2
    OriGene qSTAR qPCR primer pairs in human, mouse for CRTC2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CRTC2
      QuantiTect SYBR Green Assays in human, mouse, rat CRTC2
      QuantiFast Probe-based Assays in human, mouse, rat CRTC2

    Additional mRNA sequence: 

    AF289574.1 AK223559.1 AY360172.1 AY726597.1 BC028886.1 BC033304.1 BC053562.1 

    12 DOTS entries:

    DT.214091  DT.101983629  DT.100785690  DT.95081087  DT.102837418  DT.121436499  DT.121436562  DT.95103158 
    DT.121436527  DT.121436603  DT.92427980  DT.95198259 

    Selected AceView cDNA sequences (see all 822):

    AI884509 CR616913 AL603168 CR592329 BI753823 BF222290 AW571643 AA470113 
    BM755918 BQ072536 CR605081 BP368273 BM689549 AA683569 BQ067564 BX436727 
    BP353842 AL545553 Z42865 Z39000 BU175207 BM548720 CR615172 CR618422 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CRTC2 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c
    SP1:                                                                                -     -           -                           
    SP2:                                                  -                                                                           
    SP3:                                                  -                                                                           
    SP4:                                                                                                                              
    SP5:                                                                                                  -                           


    ECgene alternative splicing isoforms for CRTC2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CRTC2 expression in normal human tissues (normalized intensities)      CRTC2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATGAAGGAT
    CRTC2 Expression
    About this image


    CRTC2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Heart (Cardiovascular System)
             Atrioventricular Canal Cells Atrioventricular Canal
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    CRTC2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CRTC2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.406392

    UniProtKB/Swiss-Prot: CRTC2_HUMAN, Q53ET0
    Tissue specificity: Most abundantly expressed in the thymus. Present in both B and T-lymphocytes. Highly expressed
    in HEK293T cells and in insulinomas. High levels also in spleen, ovary, muscle and lung, with highest levels in
    muscle. Lower levels found in brain, colon, heart, kidney, prostate, small intestine and stomach. Weak expression
    in liver and pancreas

        Custom PCR Arrays for CRTC2
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    QuantiFast Probe-based Assays in human, mouse, rat CRTC2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRTC2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CRTC2 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Crtc21 , 5 CREB regulated transcription coactivator 21, 5 90.3(n)1
    92.47(a)1
      3 (39.21 cM)5
    743431  NM_028881.21  NP_083157.11 
     902541635 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia crtc21 CREB regulated transcription coactivator 2 67.51(n)
    66.54(a)
      101733698  XM_004921459.1  XP_004921516.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CD603162.12   -- 74.25(n)    CD603162.1 


    ENSEMBL Gene Tree for CRTC2 (if available)
    TreeFam Gene Tree for CRTC2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CRTC2 gene
    CRTC32  CRTC12  
    3 SIMAP similar genes for CRTC2 using alignment to 5 protein entries:     CRTC2_HUMAN (see all proteins):
    CRTC3/MAML2 fusion    CRTC3    CRTC1

    CRTC2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CRTC2
    PGOHUM00000235605


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    CRTC2_HUMAN, Q53ET0: Variant Cys-379, under a dominant model, linked to a recessive mutation in LKB1, may be associated
    with susceptibility to type II or non-insulin-dependent diabetes mellitus (NIDDM)


    Selected SNPs for CRTC2 (see all 244)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1925147551,2
    --153921240(+) AATGAC/GAGAGG 1 -- int10--------
    rs774479261,2
    C,F--153921274(+) AGAAGC/TGAGCA 1 -- int11Minor allele frequency- T:0.01NA 120
    rs1401903991,2
    --153921276(+) AAGCGA/TGCACG 1 -- int10--------
    rs1143008601,2
    F--153921404(+) GAGTAG/AGGTCA 1 -- int11Minor allele frequency- A:0.04NA 120
    rs1997474281,2
    --153921483(+) CACCC-/ACCCCA 1 -- int10--------
    rs1113959021,2
    C--153921484(+) ACCCAC/-CCCAC 1 -- int11Minor allele frequency- -:0.50CSA 2
    rs2022085801,2
    --153921488(+) ACCCC-/ACCTAG 1 -- int10--------
    rs1130983021,2
    C--153921590(+) ACTCAG/CATTCC 1 -- spd11Minor allele frequency- C:0.00CSA 1
    rs2002924891,2
    C--153921613(+) CACTCA/TTTGGC 2 K M mis10--------
    rs2016266671,2
    --153921738(+) GGCAGA/CCCTGG 2 G syn10--------

    HapMap Linkage Disequilibrium report for CRTC2 (153920145 - 153931132 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CRTC2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv872450CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CRTC2
    DNA2.0 Custom Variant and Variant Library Synthesis for CRTC2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608972    OMIM disorders: --

    16 diseases for CRTC2:    About MalaCards
    human t-cell leukemia virus type 1    mucoepidermoid carcinoma    leiomyosarcoma    insulinoma
    fanconi's anemia    t-cell leukemia    multiple myeloma    myeloma
    diabetes mellitus    obesity    prostate cancer    leukemia
    prostatitis    hiv-1    breast cancer    hepatitis


    CRTC2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Genetic Association Database (GAD): CRTC2
    Human Genome Epidemiology (HuGE) Navigator: CRTC2 (2 documents)

    Export disorders for CRTC2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CRTC2 gene, integrated from 10 sources (see all 79):
    (articles sorted by number of sources associating them with CRTC2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Single nucleotide polymorphisms in genes encoding LKB1 (STK11), TORC2 (CRTC2) and AMPK alpha2-subunit (PRKAA2) and risk of type 2 diabetes. (PubMed id 17950019)1, 2, 4, 9 Keshavarz P....Itakura M. (Mol. Genet. Metab. 2008)
    2. Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells. (PubMed id 14506290)1, 2, 3 Iourgenko V.... Labow M.A. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    3. TORCs: transducers of regulated CREB activity. (PubMed id 14536081)1, 2, 3 Conkright M.D.... Montminy M. (Mol. Cell 2003)
    4. Glucose controls CREB activity in islet cells via regulated phosphorylation of TORC2. (PubMed id 18626018)1, 2, 9 Jansson D.... Screaton R.A. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    5. The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector. (PubMed id 15454081)1, 2, 9 Screaton R.A.... Montminy M. (Cell 2004)
    6. TORC1 and TORC2 coactivators are required for tax activation of the human T-cell leukemia virus type 1 long terminal repeats. (PubMed id 16809310)1, 2 Siu Y.-T....Jin D.-Y. (J. Virol. 2006)
    7. Transducer of regulated CREB-binding proteins (TORCs) induce PGC- 1alpha transcription and mitochondrial biogenesis in muscle cells. (PubMed id 16980408)1, 2 Wu Z.... Stevenson S.C. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    8. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    9. PRMT5 modulates the metabolic response to fasting signals. (PubMed id 23671120)1 Tsai W.W....Montminy M. (Proc. Natl. Acad. Sci. U.S.A. 2013)
    10. 14-3-3 proteins sequester a pool of soluble TRIM32 ubiquitin ligase to repress autoubiquitylation and cytoplasmic body formation. (PubMed id 23444366)1 Ichimura T....Hachiya N. (J. Cell. Sci. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 200186 HGNC: 27301 AceView: SLC39A1andTORC2 Ensembl:ENSG00000160741 euGenes: HUgn200186
    ECgene: CRTC2 Kegg: 200186 H-InvDB: CRTC2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CRTC2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CRTC2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CRTC2 gene:
    Search GeneIP for patents involving CRTC2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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