CRTC1 Gene
protein-coding GIFtS: 59
GCID: GC19P018794
|
|
CREB regulated transcription coactivator 1(Previous name: mucoepidermoid carcinoma translocated 1 )
(Previous symbol: MECT1)
| |
Aliases
for CRTC1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| CREB Regulated Transcription Coactivator 11 2 | | FLJ140271 5 | | MECT11 2 3 5 | | Mucoepidermoid Carcinoma Translocated 11 | | TORC11 2 3 | | CREB-Regulated Transcription Coactivator 12 | | KIAA06161 3 5 | | Transducer Of Regulated CAMP Response Element-Binding Protein (CREB) 12 | | Mucoepidermoid Carcinoma Translocated Protein 12 3 | | Transducer Of CREB Protein 13 | | TORC-12 3 | | Transducer Of Regulated CAMP Response Element-Binding Protein 13 | | WAMTP12 3 | | |
Export aliases for CRTC1 gene to outside databasesPrevious GC identifers: GC19P018656 GC19P018417 |
Summaries
for CRTC1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: CRTC1_HUMAN, Q6UUV9Function: Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMPresponse element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active whendephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 withTAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potentcoactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activationof the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). In the hippocampus, involved inlate-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required fordendritic growth of developing cortical neurons (By similarity)
Gene Wiki entry for CRTC1
|
Genomic Views
for CRTC1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011295.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CRTC1 gene promoter:
Max1 SRF GCNF SRF (504 AA) CREB deltaCREB GCNF-1 GCNF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for CRTC1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CRTC1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.11 Ensembl cytogenetic band: 19p13.11 HGNC cytogenetic band: 19p13CRTC1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P018794: view genomic region
(about GC identifiers)
Start:
|
18,794,425 bp from pter |
End:
|
18,893,143 bp from pter |
Size:
|
98,719 bases |
Orientation:
|
plus strand |
|
Proteins
for CRTC1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CRTC1_HUMAN, Q6UUV9 (See
protein sequence)Recommended Name: CREB-regulated transcription coactivator 1 Size: 634 amino acids; 67300 Da
Subunit: Binds, as a tetramer, through its N-terminal region, with the bZIP domain of CREB1. 'Arg-314' in the bZIPdomain of CREB1 is essential for this interaction. Interaction, via its C-terminal, with TAF4, enhances recruitment ofTAF4 to CREB1. Binds HTLV1 Tax
Subcellular location: Cytoplasm. Nucleus. Note=Cytoplasmic when phosphorylated by SIK or AMPK and when sequestered by14-3-3 proteins (By similarity). Translocated to the nucleus on Ser-151 dephosphorylation, instigated by a number offactors including calcium ion and cAMP levels
Sequence caution: Sequence=AAH17075.3; Type=Erroneous initiation; Sequence=AAH23614.2; Type=Erroneous initiation;Sequence=AAP12463.1; Type=Erroneous initiation;
Secondary accessions: A6NMG5 O75114 Q6Y3A3 Q7LDZ2 Q8IUL3 Q8IZ34 Q8IZL1 Q8N6W3 Q96AI8 Q9H801Alternative splicing: 3 isoforms: Q6UUV9-1 Q6UUV9-2 Q6UUV9-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for CRTC1: NX_Q6UUV9
Post-translational modifications:
Phosphorylation/dephosphorylation states of Ser-151 are required for regulating transduction of CREB activity. TORCsare inactive when phosphorylated, and active when dephosphorylated at this site. This primary site of phosphorylationis mediated by SIKs (SIK1 and SIK2), is regulated by cAMP and calcium levels and is dependent on the phosphorylationof SIKs by LKB1 (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6UUV9
CRTC1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001091952.1 NP_056136.2
ENSEMBL proteins: ENSP00000345001 ENSP00000323332
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
CRTC1 for ontologies About GeneDecksing
CRTC1 Antibody Products:
Assay Products for CRTC1: |
Protein
Domains /
Families
for CRTC1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CRTC1 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6UUV9ProtoNet protein and cluster: Q6UUV9 UniProtKB/Swiss-Prot: CRTC1_HUMAN, Q6UUV9Similarity: Belongs to the TORC family |
Function
for CRTC1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CRTC1_HUMAN, Q6UUV9Function: Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMPresponse element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active whendephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 withTAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potentcoactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activationof the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). In the hippocampus, involved inlate-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required fordendritic growth of developing cortical neurons (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CRTC1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CRTC1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): CRTC1 (NM_015321) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CRTC1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRTC1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRTC1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
CRTC1 for ontologies About GeneDecksing
Animal Models:
8 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Crtc1):
CRTC1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for CRTC1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Glucose / Energy Metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Cell Signaling Technology (CST) Pathway for CRTC1
CRTC1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CRTC1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 8)
5/9 Interacting proteins for CRTC1 (Q6UUV93 ENSP000003450014) via UniProtKB, MINT, STRING, and/or I2D (see all 9)About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0019048 | virus-host interaction |
IEA | -- | | GO:0032793 | positive regulation of CREB transcription factor activity |
IEA | -- | | GO:0044419 | interspecies interaction between organisms |
-- | -- | | GO:0045944 | positive regulation of transcription from RNA polymerase II promoter |
IDA | 14536081 |
CRTC1 for ontologies About GeneDecksing
|
Drugs & Compounds
for CRTC1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CRTC1
2 HMDB Compounds for CRTC1 About this table
Search CenterWatch for drugs/clinical trials and news about CRTC1
|
Transcripts
for CRTC1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CRTC1 gene (3 alternative transcripts): NM_025021.1 NM_001098482.1 NM_015321.2 Unigene Cluster for CRTC1: CREB regulated transcription coactivator 1 Hs.371096 [show with all ESTs]Unigene Representative Sequence: NM_0010984822 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000338797(uc010ebv.3) ENST00000321949(uc002nkb.4 uc010ebw.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CRTC1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CRTC1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): CRTC1 (NM_015321) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CRTC1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRTC1 |
Additional cDNA sequence: AB014516.1 AK024089.1 AK094919.1 AY040323.1 AY186998.1 AY360171.1 BC017075.2 BC023614.2 BC028050.1 11 DOTS entries: DT.214461 DT.100782342 DT.100026239 DT.97787848 DT.100026234 DT.121491399 DT.100026238 DT.95350107 DT.95350111 DT.97841278 DT.40211933 24/173 AceView cDNA sequences (see all 173): BM928224 AA350840 BC017075 BM723456 BE466691 BM053028 BE550911 AA349930 T33668 BX343464 BG035293 AI473413 BM052733 BM723951 CR602840 AI651653 R71276 AB014516 BU627965 AK094919 AA252605 AI016951 BQ219773 CD172360
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CRTC1 (see all 6) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | · | 13c | ^ | 14a | · | 14b |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for CRTC1
|
Expression
for CRTC1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CRTC1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTCCGCCAGG
About this image
See CRTC1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CRTC1
SOURCE GeneReport for Unigene cluster: Hs.371096
UniProtKB/Swiss-Prot: CRTC1_HUMAN, Q6UUV9Tissue specificity: Highly expressed in adult and fetal brain. Located to specific regions such as the prefrontalcortex and cerebellum. Very low expression in other tissues such as heart, spleen, lung, skeletal muscle, salivarygland, ovary and kidney
SABiosciences Custom PCR Arrays for CRTC1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CRTC1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CRTC1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CRTC1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRTC1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRTC1 |
Orthologs
for CRTC1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CRTC1 gene from 5/17 species (see all 17) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Crtc11 , 5 |
CREB regulated transcription coactivator 11, 5 |
86.28(n)1
91.23(a)1 |
|
8 (34.15 cM)5
3820561 NM_001004062.21 NP_001004062.11
703823555 |
chicken
(Gallus gallus) |
Aves |
CRTC11 |
CREB regulated transcription coactivator 1 |
78.54(n)
85.21(a) |
|
771015 XM_003642883.1 XP_003642931.1 |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.126692 |
Xenopus laevis transcribed sequence with weak similarity to protein pirT00388 (H.sapiens) T00388 hypothetical protein KIAA0616 - human (fragment) less |
75.95(n) |
|
CF547669.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
si:ch211-255d18.11 |
si:ch211-255d18.1 |
67.71(n)
68.28(a) |
|
571344 XM_003199425.1 XP_003199473.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
TORC6 |
TORC |
17(a) |
1 → many |
3L(17653208-17662334) |
ENSEMBL Gene Tree for CRTC1 (if available)
TreeFam Gene Tree for CRTC1 (if available) |
Paralogs
for CRTC1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CRTC1 gene
- CRTC32 CRTC22
2 SIMAP similar genes for CRTC1 using alignment to 3 protein entries: CRTC1_HUMAN (see all proteins):CRTC3/MAML2 fusion CRTC2
CRTC1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for CRTC1
PGOHUM00000240643
|
Genomic Variants
for CRTC1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CRTC1 (18794425 - 18893143 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CRTC1
1 Indel: 102797 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CRTC1 |
|
Disorders
/ Diseases
for CRTC1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CRTC1 for disorders About GeneDecksing
OMIM gene information: 607536
OMIM disorders: --
UniProtKB/Swiss-Prot: CRTC1_HUMAN, Q6UUV9
Note=A chromosomal aberration involving CRTC1 is found in mucoepidermoid carcinomas, benign Warthin tumors andclear cell hidradenomas. Translocation t(11;19)(q21;p13) with MAML2. The fusion protein consists of the N-terminus ofCRTC1 joined to the C-terminus of MAML2. The reciprocal fusion protein consisting of the N-terminus of MAML2 joined tothe C-terminus of CRTC1 has been detected in a small number of mucoepidermoid carcinomas
20/26  diseases for CRTC1 (see all 26): About MalaCardsmucoepidermoid carcinoma mucoepidermoid salivary gland carcinoma human t-cell leukemia virus type 1 epithelial-myoepithelial carcinoma
carcinoma clear cell hidradenoma salivary gland cancer maxillary sinus cancer
hidradenoma cutaneous mucoepidermoid carcinoma adenosquamous carcinoma lipoadenoma
cervical adenosquamous carcinoma warthin tumor myoepithelial carcinoma tuberous sclerosis
cutaneous t cell lymphoma renal cell carcinoma t-cell leukemia sinus cancer
8 diseases from the University of Copenhagen DISEASES database for CRTC1:Mucoepidermoid carcinoma Cutaneous mucoepidermoid carcinoma Lipoadenoma Lacrimal gland cancer
Hidradenoma Cervical adenosquamous carcinoma epithelial-myoepithelial carcinoma Necrotizing sialometaplasia 1 Novoseek disease relationship for CRTC1 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| carcinoma mucoepidermoid |
80.9 |
5 |
16444749 (1), 17334997 (1) |
Human Genome Epidemiology (HuGE) Navigator: CRTC1 (4 documents)
Export disorders for CRTC1 gene to outside databases
|
Publications
for CRTC1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CRTC1 gene, integrated from 9 sources (see all 55):
(articles sorted by number of sources associating them with CRTC1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells. (PubMed id 14506290)1, 2, 3, 9 Iourgenko V.... Labow M.A. (2003)
- TORCs: transducers of regulated CREB activity. (PubMed id 14536081)1, 2, 3 Conkright M.D.... Montminy M. (2003)
- t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway. (PubMed id 12539049)1, 2, 3 Tonon G.... Kaye F.J. (2003)
- Activation of cAMP response element-mediated gene expression by regulated nuclear transport of TORC proteins. (PubMed id 15589160)1, 2, 9 Bittinger M.A....Labow M. (2004)
- Silencing the constitutive active transcription factor CREB by the LKB1-SIK signaling cascade. (PubMed id 16817901)1, 2 Katoh Y....Okamoto M. (2006)
- TORC1 and TORC2 coactivators are required for tax activation of the human T-cell leukemia virus type 1 long terminal repeats. (PubMed id 16809310)1, 2 Siu Y.T....Jin D.Y. (2006)
- Transducer of regulated CREB-binding proteins (TORCs) induce PGC- 1alpha transcription and mitochondrial biogenesis in muscle cells. (PubMed id 16980408)1, 2 Wu Z.... Stevenson S.C. (2006)
- Clear cell hidradenoma of the skin-a third tumor type with a t(11;19)--associated TORC1-MAML2 gene fusion. (PubMed id 15729701)1, 2 Behboudi A.... Stenman G. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
|
External Searches for CRTC1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CRTC1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CRTC1 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing CRTC1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for CRTC1 gene:
Search GeneIP for patents involving CRTC1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for CRTC1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | OriGene Antibodies for CRTC1 | | OriGene shRNA RFP for CRTC1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CRTC1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CRTC1 | | | OriGene Protein Over-expression Lysate for CRTC1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CRTC1 | | OriGene 3'-UTR Clone for CRTC1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CRTC1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CRTC1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for CRTC1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CRTC1 | | OriGene Custom Protein Services for CRTC1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CRTC1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CRTC1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CRTC1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CRTC1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRTC1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CRTC1 |
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| | Antibodies & Assays for CRTC1 (TORC1) |
| | | | Search Tocris compounds for CRTC1 |
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 | | | CRTC1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRTC1 |
|  |  |  | | | | ThermoFisher Antibody for CRTC1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRTC1 |
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