Aliases for CRTC1 Gene
External Ids for CRTC1 Gene
Previous Symbols for CRTC1 Gene
GeneCards Summary for CRTC1 Gene
CRTC1 (CREB Regulated Transcription Coactivator 1) is a Protein Coding gene. Diseases associated with CRTC1 include lacrimal gland cancer and cutaneous mucoepidermoid carcinoma. Among its related pathways are Glucose / Energy Metabolism and HTLV-I infection. GO annotations related to this gene include cAMP response element binding protein binding. An important paralog of this gene is CRTC3.
UniProtKB/Swiss-Prot for CRTC1 Gene
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 Ser-133 phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons (By similarity). In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock.