Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CRTC1 Gene

protein-coding   GIFtS: 62
GCID: GC19P018794

CREB Regulated Transcription Coactivator 1

(Previous name: mucoepidermoid carcinoma translocated 1)
(Previous symbol: MECT1)
  See CRTC1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
CREB Regulated Transcription Coactivator 11 2     Mucoepidermoid Carcinoma Translocated 11
MECT11 2 3 5     Transducer Of Regulated CAMP Response Element-Binding Protein1
Mucoepidermoid Carcinoma Translocated Protein 12 3     CREB-Regulated Transcription Coactivator 12
TORC-12 3     Transducer Of Regulated CAMP Response Element-Binding Protein (CREB) 12
TORC12 3     Transducer Of CREB Protein 13
WAMTP12 3     Transducer Of Regulated CAMP Response Element-Binding Protein 13
KIAA06163 5     FLJ140275

External Ids:    HGNC: 160621   Entrez Gene: 233732   Ensembl: ENSG000001056627   OMIM: 6075365   UniProtKB: Q6UUV93   

Export aliases for CRTC1 gene to outside databases

Previous GC identifers: GC19P018656 GC19P018417


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for CRTC1 Gene:
CRTC1 (CREB regulated transcription coactivator 1) is a protein-coding gene. Diseases associated with CRTC1 include clear cell hidradenoma, and mucoepidermoid salivary gland carcinoma. GO annotations related to this gene include cAMP response element binding protein binding. An important paralog of this gene is CRTC3.

UniProtKB/Swiss-Prot: CRTC1_HUMAN, Q6UUV9
Function: Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant
cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when
dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1
with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent
coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX
activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). In the hippocampus,
involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be
required for dendritic growth of developing cortical neurons (By similarity)

Gene Wiki entry for CRTC1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CRTC1 gene promoter:
         Max1   SRF   GCNF   SRF (504 AA)   CREB   deltaCREB   GCNF-1   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CRTC1 promoter sequence
   Search Chromatin IP Primers for CRTC1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CRTC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.11   Ensembl cytogenetic band:  19p13.11   HGNC cytogenetic band: 19p13

CRTC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRTC1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P018794:  view genomic region     (about GC identifiers)

Start:
18,794,425 bp from pter      End:
18,893,143 bp from pter
Size:
98,719 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CRTC1_HUMAN, Q6UUV9 (See protein sequence)
Recommended Name: CREB-regulated transcription coactivator 1  
Size: 634 amino acids; 67300 Da
Subunit: Binds, as a tetramer, through its N-terminal region, with the bZIP domain of CREB1. 'Arg-314' in the bZIP
domain of CREB1 is essential for this interaction. Interaction, via its C-terminal, with TAF4, enhances
recruitment of TAF4 to CREB1. Binds HTLV1 Tax
Sequence caution: Sequence=AAH17075.3; Type=Erroneous initiation; Sequence=AAH23614.2; Type=Erroneous initiation;
Sequence=AAP12463.1; Type=Erroneous initiation;
Secondary accessions: A6NMG5 O75114 Q6Y3A3 Q7LDZ2 Q8IUL3 Q8IZ34 Q8IZL1 Q8N6W3 Q96AI8 Q9H801
Alternative splicing: 3 isoforms:  Q6UUV9-1   Q6UUV9-2   Q6UUV9-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CRTC1: NX_Q6UUV9

Explore proteomics data for CRTC1 at MOPED

Post-translational modifications: 

  • Phosphorylation/dephosphorylation states of Ser-151 are required for regulating transduction of CREB activity.
    TORCs are inactive when phosphorylated, and active when dephosphorylated at this site. This primary site of
    phosphorylation is mediated by SIKs (SIK1 and SIK2), is regulated by cAMP and calcium levels and is dependent on
    the phosphorylation of SIKs by LKB1 (By similarity)1
  • Ubiquitination2 at Lys47
  • Modification sites at PhosphoSitePlus

  • See CRTC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001091952.1  NP_056136.2  

    ENSEMBL proteins: 
     ENSP00000323332   ENSP00000345001   ENSP00000468893   ENSP00000469285  

    CRTC1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for CRTC1
    OriGene Protein Over-expression Lysate for CRTC1
    OriGene MassSpec for CRTC1
    OriGene Custom Protein Services for CRTC1
    GenScript Custom Purified and Recombinant Proteins Services for CRTC1
    Novus Biologicals CRTC1 Protein
    Novus Biologicals CRTC1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CRTC1

     
    Search eBioscience for Proteins for CRTC1 

     
    antibodies-online proteins for CRTC1 (3 products) 

     
    antibodies-online peptides for CRTC1

    CRTC1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CRTC1
    R&D Systems Antibodies for CRTC1 (TORC1)
    Cell Signaling Technology (CST) Antibodies for CRTC1  (TORC1)
    OriGene Antibodies for CRTC1
    OriGene Custom Antibody Services for CRTC1
    Novus Biologicals CRTC1 Antibodies
    Abcam antibodies for CRTC1
    Cloud-Clone Corp. Antibodies for CRTC1
    ThermoFisher Antibody for CRTC1
    antibodies-online antibodies for CRTC1 (60 products) 

    CRTC1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CRTC1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CRTC1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CRTC1
    Cloud-Clone Corp. CLIAs for CRTC1
    Search eBioscience for ELISAs for CRTC1 
    antibodies-online kits for CRTC1 (5 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    4 InterPro protein domains:
     IPR024786 TORC
     IPR024783 TORC_N
     IPR024784 TORC_M
     IPR024785 TORC_C

    Graphical View of Domain Structure for InterPro Entry Q6UUV9

    ProtoNet protein and cluster: Q6UUV9

    UniProtKB/Swiss-Prot: CRTC1_HUMAN, Q6UUV9
    Similarity: Belongs to the TORC family


    Find genes that share domains with CRTC1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CRTC1_HUMAN, Q6UUV9
    Function: Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant
    cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when
    dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1
    with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent
    coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX
    activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). In the hippocampus,
    involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be
    required for dendritic growth of developing cortical neurons (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI14506290
    GO:0008140cAMP response element binding protein binding IDA14536081
         
    Find genes that share ontologies with CRTC1           About GenesLikeMe


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Crtc1):
     adipose tissue  behavior/neurological  cardiovascular system  endocrine/exocrine gland  growth/size/body 
     hematopoietic system  homeostasis/metabolism  reproductive system 

    Find genes that share phenotypes with CRTC1           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CRTC1

    miRNA
    Products:
        
    miRTarBase miRNAs that target CRTC1:
    hsa-mir-125b-5p (MIRT045900)

    Block miRNA regulation of human, mouse, rat CRTC1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CRTC1 (see all 36):
    hsa-miR-128 hsa-miR-16-1* hsa-miR-3074-3p hsa-miR-449a hsa-miR-548m hsa-miR-556-3p hsa-miR-1290 hsa-miR-3163
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CRTC1
    Predesigned siRNA for gene silencing in human, mouse, rat CRTC1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CRTC1

    Clone
    Products:
         
    OriGene clones in human, mouse for CRTC1 (see all 13)
    OriGene ORF clones in mouse, rat for CRTC1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CRTC1 (NM_015321)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRTC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRTC1
    Addgene plasmids for CRTC1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CRTC1
    Browse ESI BIO Cell Lines and PureStem Progenitors for CRTC1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRTC1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    CRTC1_HUMAN, Q6UUV9: Cytoplasm. Nucleus. Note=Cytoplasmic when phosphorylated by SIK or AMPK and when sequestered
    by 14-3-3 proteins (By similarity). Translocated to the nucleus on Ser-151 dephosphorylation, instigated by a
    number of factors including calcium ion and cAMP levels
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    golgi apparatus4
    plasma membrane4
    cytosol3

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane IDA--

    Find genes that share ontologies with CRTC1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for CRTC1 About    
    See pathways by source

    SuperPathContained pathways About
    1HTLV-I infection
    HTLV-I infection
    2Glucose / Energy Metabolism
    Glucose / Energy Metabolism
    3BDNF signaling pathway
    BDNF signaling pathway


    Find genes that share SuperPaths with CRTC1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for CRTC1
        Glucose / Energy Metabolism

    1 BioSystems Pathway for CRTC1
        BDNF signaling pathway


    1 Kegg Pathway  (Kegg details for CRTC1):
        HTLV-I infection

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CRTC1
    Interactions:

        GeneGlobe Interaction Network for CRTC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for CRTC1 (Q6UUV93 ENSP000003450014) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MEIS1O004703, ENSP000002723694I2D: score=1 STRING: ENSP00000272369
    YWHAEP622583, ENSP000002643354I2D: score=1 STRING: ENSP00000264335
    YWHAGP619813, ENSP000003063304I2D: score=1 STRING: ENSP00000306330
    CREB1P162203, ENSP000003876994I2D: score=3 STRING: ENSP00000387699
    YWHAHQ049173, ENSP000002489754I2D: score=1 STRING: ENSP00000248975
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0016032viral process IEA--
    GO:0019048modulation by virus of host morphology or physiology ----
    GO:0032793positive regulation of CREB transcription factor activity IEA--
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IDA14536081

    Find genes that share ontologies with CRTC1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CRTC1

    2 HMDB Compounds for CRTC1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Cyclic AMPCyclic AMP (see all 19)60-92-4--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for CRTC1 gene (3 alternative transcripts): 
    NM_025021.1  NM_001098482.1  NM_015321.2  

    Unigene Cluster for CRTC1:

    CREB regulated transcription coactivator 1
    Hs.371096  [show with all ESTs]
    Unigene Representative Sequence: NM_001098482
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000321949(uc002nkb.4 uc010ebw.3) ENST00000338797(uc010ebv.3)
    ENST00000594658 ENST00000601916
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CRTC1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CRTC1 (see all 36):
    hsa-miR-128 hsa-miR-16-1* hsa-miR-3074-3p hsa-miR-449a hsa-miR-548m hsa-miR-556-3p hsa-miR-1290 hsa-miR-3163
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CRTC1
    Predesigned siRNA for gene silencing in human, mouse, rat CRTC1
    Clone
    Products:
         
    OriGene clones in human, mouse for CRTC1 (see all 13)
    OriGene ORF clones in mouse, rat for CRTC1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CRTC1 (NM_015321)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRTC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRTC1
    Addgene plasmids for CRTC1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CRTC1
    OriGene qSTAR qPCR primer pairs in human, mouse for CRTC1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CRTC1
      QuantiTect SYBR Green Assays in human, mouse, rat CRTC1
      QuantiFast Probe-based Assays in human, mouse, rat CRTC1

    Additional mRNA sequence: 

    AB014516.1 AK024089.1 AK094919.1 AY040323.1 AY186998.1 AY360171.1 BC017075.2 BC023614.2 
    BC028050.1 

    11 DOTS entries:

    DT.214461  DT.100782342  DT.100026239  DT.97787848  DT.100026234  DT.121491399  DT.100026238  DT.95350107 
    DT.95350111  DT.97841278  DT.40211933 

    Selected AceView cDNA sequences (see all 173):

    BC023614 BG035293 AY360171 R71276 BM053028 BQ717768 AI651653 AA252605 
    AA349930 AI470102 CK903673 BM053029 BX343464 CR602840 CR611462 AI016951 
    T33668 BM723456 AI473106 BU195762 BM928224 AY040323 BM723951 BU627965 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CRTC1 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b
    SP1:                                                                                                            
    SP2:                                                                                                            
    SP3:                                                        -     -     -     -                                 
    SP4:                                                                          -                                 
    SP5:                                                              -     -     -                                 


    ECgene alternative splicing isoforms for CRTC1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    CRTC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCCGCCAGG
    CRTC1 Expression
    About this image

    CRTC1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CRTC1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.371096

    UniProtKB/Swiss-Prot: CRTC1_HUMAN, Q6UUV9
    Tissue specificity: Highly expressed in adult and fetal brain. Located to specific regions such as the prefrontal
    cortex and cerebellum. Very low expression in other tissues such as heart, spleen, lung, skeletal muscle,
    salivary gland, ovary and kidney

        Custom PCR Arrays for CRTC1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CRTC1
    OriGene qSTAR qPCR primer pairs in human, mouse for CRTC1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CRTC1
    QuantiTect SYBR Green Assays in human, mouse, rat CRTC1
    QuantiFast Probe-based Assays in human, mouse, rat CRTC1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRTC1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for CRTC1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Crtc11 , 5 CREB regulated transcription coactivator 11, 5 85.27(n)1
    89.63(a)1
      8 (34.15 cM)5
    3820561  NM_001004062.21  NP_001004062.11 
     703823555 
    chicken
    (Gallus gallus)
    Aves CRTC11 CREB regulated transcription coactivator 1 78.11(n)
    84.58(a)
      771015  XM_003642883.2  XP_003642931.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.126692 Xenopus laevis transcribed sequence with weak similarity more 75.95(n)    CF547669.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1018862401 CREB-regulated transcription coactivator 1-like 68.18(n)
    69.28(a)
      101886240  XM_005172833.1  XP_005172890.1 


    ENSEMBL Gene Tree for CRTC1 (if available)
    TreeFam Gene Tree for CRTC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for CRTC1 gene
    CRTC32  CRTC22  
    2 SIMAP similar genes for CRTC1 using alignment to 3 protein entries:     CRTC1_HUMAN (see all proteins):
    CRTC3/MAML2 fusion    CRTC2

    Find genes that share paralogs with CRTC1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for CRTC1
    PGOHUM00000240643


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for CRTC1 (see all 2052)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs678027431,2
    C--18792657(+) AAAAA-/AA/AAA
            
    TCCCA
    4 -- us2k1 cds12NA 4
    rs1426591251,2
    --18792754(+) GCAGAA/GATTGC 2 -- us2k10--------
    rs1899621701,2
    --18792761(+) TTGCAA/GTGAGC 2 -- us2k10--------
    rs1822632981,2
    --18792813(+) GACTCC/TGTCTC 2 -- us2k10--------
    rs2012423051,2
    --18792873(+) AAATC-/TAGATAT 2 -- us2k10--------
    rs40066321,2
    C--18792874(-) tatat-/AT    
       
    /ATAT
    CGATT
    2 -- us2k10--------
    rs717703221,2
    C--18792875(+) ATCGA-/AT    
       
    /ATAT
    TATAT
    2 -- us2k10--------
    rs711687581,2
    C--18792892(+) TATAT-/A/AT  
            
    TTAAC
    2 -- us2k11NA 2
    rs1469038571,2
    --18792993(+) TGTGTA/GCTTGT 2 -- us2k10--------
    rs800390531,2
    F--18793091(+) ATATAA/CACTTT 2 -- us2k11Minor allele frequency- C:0.02WA 118

    HapMap Linkage Disequilibrium report for CRTC1 (18794425 - 18893143 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CRTC1 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2674391CNV Deletion23128226
    nsv2433CNV Insertion18451855
    nsv2431CNV Insertion18451855
    esv2610416CNV Insertion19546169
    esv999375CNV Insertion20482838
    nsv911282CNV Loss21882294
    nsv833777CNV Loss17160897
    nsv911295CNV Loss21882294
    dgv3784n71CNV Loss21882294
    nsv911296CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CRTC1
    DNA2.0 Custom Variant and Variant Library Synthesis for CRTC1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 607536    OMIM disorders: --

    UniProtKB/Swiss-Prot: CRTC1_HUMAN, Q6UUV9
  • Note=A chromosomal aberration involving CRTC1 is found in mucoepidermoid carcinomas, benign Warthin
    tumors and clear cell hidradenomas. Translocation t(11;19)(q21;p13) with MAML2. The fusion protein consists of
    the N-terminus of CRTC1 joined to the C-terminus of MAML2. The reciprocal fusion protein consisting of the
    N-terminus of MAML2 joined to the C-terminus of CRTC1 has been detected in a small number of mucoepidermoid
    carcinomas

  • 11 diseases for CRTC1:    
    About MalaCards
    clear cell hidradenoma    mucoepidermoid salivary gland carcinoma    lacrimal gland cancer    warthin tumor
    cutaneous mucoepidermoid carcinoma    lipoadenoma    mucoepidermoid carcinoma    necrotizing sialometaplasia
    epithelial-myoepithelial carcinoma    cervical adenosquamous carcinoma    hidradenoma

    8 diseases from the University of Copenhagen DISEASES database for CRTC1:
    Mucoepidermoid carcinoma     Cutaneous mucoepidermoid carcinoma     Lipoadenoma     Hidradenoma
    Cervical adenosquamous carcinoma     Lacrimal gland cancer     epithelial-myoepithelial carcinoma     Necrotizing sialometaplasia

    Find genes that share disorders with CRTC1           About GenesLikeMe

    1 Novoseek inferred disease relationship for CRTC1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma mucoepidermoid 80.9 5 16444749 (1), 17334997 (1)

    Genetic Association Database (GAD): CRTC1
    Human Genome Epidemiology (HuGE) Navigator: CRTC1 (4 documents)

    Export disorders for CRTC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CRTC1 gene, integrated from 10 sources (see all 63):
    (articles sorted by number of sources associating them with CRTC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells. (PubMed id 14506290)1, 2, 3, 9 Iourgenko V.... Labow M.A. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    2. TORCs: transducers of regulated CREB activity. (PubMed id 14536081)1, 2, 3 Conkright M.D.... Montminy M. (Mol. Cell 2003)
    3. t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway. (PubMed id 12539049)1, 2, 3 Tonon G.... Kaye F.J. (Nat. Genet. 2003)
    4. Activation of cAMP response element-mediated gene expression by regulated nuclear transport of TORC proteins. (PubMed id 15589160)1, 2, 9 Bittinger M.A.... Labow M. (Curr. Biol. 2004)
    5. Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. (PubMed id 21102462)1, 4 Elks C.E....Murray A. (Nat. Genet. 2010)
    6. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    7. Silencing the constitutive active transcription factor CREB by the LKB1-SIK signaling cascade. (PubMed id 16817901)1, 2 Katoh Y....Okamoto M. (FEBS J. 2006)
    8. TORC1 and TORC2 coactivators are required for tax activation of the human T-cell leukemia virus type 1 long terminal repeats. (PubMed id 16809310)1, 2 Siu Y.-T....Jin D.-Y. (J. Virol. 2006)
    9. Transducer of regulated CREB-binding proteins (TORCs) induce PGC- 1alpha transcription and mitochondrial biogenesis in muscle cells. (PubMed id 16980408)1, 2 Wu Z.... Stevenson S.C. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    10. Clear cell hidradenoma of the skin-a third tumor type with a t(11;19)-associated TORC1-MAML2 gene fusion. (PubMed id 15729701)1, 2 Behboudi A.... Stenman G. (Genes Chromosomes Cancer 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 23373 HGNC: 16062 AceView: MECT1 Ensembl:ENSG00000105662 euGenes: HUgn23373
    ECgene: CRTC1 Kegg: 23373 H-InvDB: CRTC1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA0616

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CRTC1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CRTC1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CRTC1 gene:
    Search GeneIP for patents involving CRTC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     EMD Millipore Mono- and Polyclonal Antibodies for the study of CRTC1
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Antibodies for CRTC1 (TORC1)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for CRTC1   OriGene RNAi products in human, mouse, rat for CRTC1  
     OriGene qPCR primer pairs and template standards for CRTC1   OriGene Protein Over-expression Lysate for CRTC1  
     OriGene MassSpec for CRTC1   OriGene clones in human, mouse for CRTC1  
     OriGene qSTAR qPCR primer pairs in human, mouse for CRTC1   OriGene Purified Protein for CRTC1  
     OriGene ORF clones in mouse, rat for CRTC1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CRTC1   OriGene Custom Protein Services for CRTC1  

     
     
     Block miRNA regulation of human, mouse, rat CRTC1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CRTC1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CRTC1 Predesigned siRNA for gene silencing in human, mouse, rat CRTC1
     QuantiFast Probe-based Assays in human, mouse, rat CRTC1 QuantiTect SYBR Green Assays in human, mouse, rat CRTC1
     Custom PCR Arrays for CRTC1 Search Chromatin IP Primers for CRTC1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CRTC1  GeneGlobe Interaction Network for CRTC1
     Regulatory tfbs in CRTC1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for CRTC1 GenScript cDNA clones with any tag delivered in your preferred vector for CRTC1
     GenScript Custom Assay Services for CRTC1 GenScript Custom overexpressing Cell Line Services for CRTC1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for CRTC1  (TORC1)

     Search Tocris compounds for CRTC1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CRTC1 antibodies
     CRTC1 proteins
     CRTC1 lysates
     Antibodies for CRTC1
     See all of Abcam's Antibodies, Kits and Proteins for CRTC1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for CRTC1
     Antibodies for CRTC1
     ELISAs for CRTC1
     CLIAs for CRTC1



     Browse ESI BIO Cell Lines and PureStem Progenitors for CRTC1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRTC1
     Browse SwitchGear 3'UTR luciferase reporter plasmids for CRTC1
     SwitchGear Promoter luciferase reporter plasmids for CRTC1
     ThermoFisher Antibody for CRTC1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRTC1
     Browse compounds at ApexBio
     Addgene plasmids for CRTC1
      Search eBioscience for proteins for CRTC1
      Search eBioscience for elisas for CRTC1
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for CRTC1
     antibodies-online antibodies for CRTC1 (60 products)
     antibodies-online kits for CRTC1 (5 products)
     antibodies-online peptides for CRTC1
     antibodies-online proteins for CRTC1 (3 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CRTC1 gene at Home site.
    Version: 3.12.252 27 Nov 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4