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Aliases for CRTC1 Gene

Aliases for CRTC1 Gene

  • CREB Regulated Transcription Coactivator 1 2 3 5
  • Mucoepidermoid Carcinoma Translocated Protein 1 3 4
  • TORC-1 3 4
  • WAMTP1 3 4
  • MECT1 3 4
  • TORC1 3 4
  • Transducer Of Regulated CAMP Response Element-Binding Protein (CREB) 1 3
  • Transducer Of Regulated CAMP Response Element-Binding Protein 1 4
  • Transducer Of Regulated CAMP Response Element-Binding Protein 2
  • Mucoepidermoid Carcinoma Translocated 1 2
  • Transducer Of CREB Protein 1 4
  • KIAA0616 4

External Ids for CRTC1 Gene

Previous HGNC Symbols for CRTC1 Gene

  • MECT1

Previous GeneCards Identifiers for CRTC1 Gene

  • GC19P018794
  • GC19P018417

Summaries for CRTC1 Gene

GeneCards Summary for CRTC1 Gene

CRTC1 (CREB Regulated Transcription Coactivator 1) is a Protein Coding gene. Diseases associated with CRTC1 include Mucoepidermoid Carcinoma and Clear Cell Hidradenoma. Among its related pathways are HTLV-I infection and Glucose / Energy Metabolism. GO annotations related to this gene include cAMP response element binding protein binding. An important paralog of this gene is CRTC3.

UniProtKB/Swiss-Prot for CRTC1 Gene

  • Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 Ser-133 phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons (By similarity). In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock.

Gene Wiki entry for CRTC1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRTC1 Gene

Genomics for CRTC1 Gene

Regulatory Elements for CRTC1 Gene

Enhancers for CRTC1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CRTC1 on UCSC Golden Path with GeneCards custom track

Promoters for CRTC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CRTC1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CRTC1 Gene

Chromosome:
19
Start:
18,683,615 bp from pter
End:
18,782,333 bp from pter
Size:
98,719 bases
Orientation:
Plus strand

Genomic View for CRTC1 Gene

Genes around CRTC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRTC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRTC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRTC1 Gene

Proteins for CRTC1 Gene

  • Protein details for CRTC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UUV9-CRTC1_HUMAN
    Recommended name:
    CREB-regulated transcription coactivator 1
    Protein Accession:
    Q6UUV9
    Secondary Accessions:
    • A6NMG5
    • O75114
    • Q6Y3A3
    • Q7LDZ2
    • Q8IUL3
    • Q8IZ34
    • Q8IZL1
    • Q8N6W3
    • Q96AI8
    • Q9H801

    Protein attributes for CRTC1 Gene

    Size:
    634 amino acids
    Molecular mass:
    67300 Da
    Quaternary structure:
    • Binds, as a tetramer, through its N-terminal region, with the bZIP domain of CREB1. Arg-314 in the bZIP domain of CREB1 is essential for this interaction. Interaction, via its C-terminal, with TAF4, enhances recruitment of TAF4 to CREB1. Binds HTLV1 Tax.
    SequenceCaution:
    • Sequence=AAH17075.3; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH23614.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAP12463.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CRTC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CRTC1 Gene

Proteomics data for CRTC1 Gene at MOPED

Post-translational modifications for CRTC1 Gene

  • Phosphorylation/dephosphorylation states of Ser-151 are required for regulating transduction of CREB activity. TORCs are inactive when phosphorylated, and active when dephosphorylated at this site. This primary site of phosphorylation is mediated by SIKs (SIK1 and SIK2), is regulated by cAMP and calcium levels and is dependent on the phosphorylation of SIKs by LKB1 (By similarity).
  • Ubiquitination at Lys 47
  • Modification sites at PhosphoSitePlus

Other Protein References for CRTC1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CRTC1 (TORC1)

No data available for DME Specific Peptides for CRTC1 Gene

Domains & Families for CRTC1 Gene

Protein Domains for CRTC1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CRTC1 Gene

Graphical View of Domain Structure for InterPro Entry

Q6UUV9

UniProtKB/Swiss-Prot:

CRTC1_HUMAN :
  • Belongs to the TORC family.
Family:
  • Belongs to the TORC family.
genes like me logo Genes that share domains with CRTC1: view

No data available for Gene Families for CRTC1 Gene

Function for CRTC1 Gene

Molecular function for CRTC1 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 Ser-133 phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons (By similarity). In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock.
genes like me logo Genes that share phenotypes with CRTC1: view

Animal Models for CRTC1 Gene

MGI Knock Outs for CRTC1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CRTC1 Gene

Localization for CRTC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRTC1 Gene

Cytoplasm. Nucleus. Note=Cytoplasmic when phosphorylated by SIK or AMPK and when sequestered by 14-3-3 proteins (PubMed:16817901). Translocated to the nucleus on Ser-151 dephosphorylation, instigated by a number of factors including calcium ion and cAMP levels (PubMed:15589160). Light stimulation triggers a nuclear accumulation in the suprachiasmatic nucleus (SCN) of the brain (By similarity). {ECO:0000250 UniProtKB:Q68ED7, ECO:0000269 PubMed:15589160, ECO:0000269 PubMed:16817901}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CRTC1 Gene COMPARTMENTS Subcellular localization image for CRTC1 gene
Compartment Confidence
nucleus 5
plasma membrane 5
golgi apparatus 4
cytosol 3

Gene Ontology (GO) - Cellular Components for CRTC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0030425 dendrite IEA --
genes like me logo Genes that share ontologies with CRTC1: view

Pathways & Interactions for CRTC1 Gene

genes like me logo Genes that share pathways with CRTC1: view

Pathways by source for CRTC1 Gene

1 Cell Signaling Technology pathway for CRTC1 Gene
1 BioSystems pathway for CRTC1 Gene
1 KEGG pathway for CRTC1 Gene

SIGNOR curated interactions for CRTC1 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for CRTC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0016032 viral process IEA --
GO:0032793 positive regulation of CREB transcription factor activity IEA,ISS --
GO:0043153 entrainment of circadian clock by photoperiod IEA,ISS --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA,IDA 14536081
genes like me logo Genes that share ontologies with CRTC1: view

Drugs & Compounds for CRTC1 Gene

(9) Drugs for CRTC1 Gene - From: DGIdb and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0
BEZ235 Pharma Inhibition, inhibitor PI3K/mTOR inhibitor, Kinase Inhibitors, Phosphatidylinositol-3- kinase (PI-3K) inhibitors, PI3K/mTOR Inhibitors 0
DS-3078a Pharma Inhibition, inhibitor TORC1/2 kinase inhibitor 0
DS-7423 Pharma inhibitor, Biomarker PI3K/mTOR inhibitor, PI3K/mTOR Inhibitors 0
INK128 Pharma inhibitor 0
genes like me logo Genes that share compounds with CRTC1: view

Transcripts for CRTC1 Gene

Unigene Clusters for CRTC1 Gene

CREB regulated transcription coactivator 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CRTC1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b
SP1:
SP2:
SP3: - - - -
SP4: -
SP5: - - -
SP6:

Relevant External Links for CRTC1 Gene

GeneLoc Exon Structure for
CRTC1
ECgene alternative splicing isoforms for
CRTC1

Expression for CRTC1 Gene

mRNA expression in normal human tissues for CRTC1 Gene

mRNA differential expression in normal tissues according to GTEx for CRTC1 Gene

This gene is overexpressed in Brain - Cerebellum (x5.2) and Brain - Cerebellar Hemisphere (x4.0).

Protein differential expression in normal tissues from HIPED for CRTC1 Gene

This gene is overexpressed in Frontal cortex (13.0), Placenta (11.9), CD8 Tcells (7.1), CD4 Tcells (6.6), and Testis (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CRTC1 Gene



SOURCE GeneReport for Unigene cluster for CRTC1 Gene Hs.371096

mRNA Expression by UniProt/SwissProt for CRTC1 Gene

Q6UUV9-CRTC1_HUMAN
Tissue specificity: Highly expressed in adult and fetal brain. Located to specific regions such as the prefrontal cortex and cerebellum. Very low expression in other tissues such as heart, spleen, lung, skeletal muscle, salivary gland, ovary and kidney.
genes like me logo Genes that share expression patterns with CRTC1: view

Protein tissue co-expression partners for CRTC1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CRTC1 Gene

Orthologs for CRTC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CRTC1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CRTC1 35
  • 91.46 (n)
  • 95.82 (a)
CRTC1 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CRTC1 35
  • 90.02 (n)
  • 94.2 (a)
-- 36
  • 81 (a)
OneToMany
-- 36
  • 92 (a)
OneToMany
-- 36
  • 65 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Crtc1 35
  • 85.27 (n)
  • 89.63 (a)
Crtc1 16
Crtc1 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CRTC1 35
  • 99.37 (n)
  • 99.84 (a)
CRTC1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Crtc1 35
  • 84.8 (n)
  • 89.31 (a)
oppossum
(Monodelphis domestica)
Mammalia CRTC1 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CRTC1 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves CRTC1 35
  • 78.11 (n)
  • 84.58 (a)
CRTC1 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia crtc1 35
  • 72.19 (n)
  • 82.45 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12669 35
zebrafish
(Danio rerio)
Actinopterygii LOC101886240 35
  • 68.18 (n)
  • 69.28 (a)
crtc1a 36
  • 68 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4116 36
  • 39 (a)
OneToOne
Species with no ortholog for CRTC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CRTC1 Gene

ENSEMBL:
Gene Tree for CRTC1 (if available)
TreeFam:
Gene Tree for CRTC1 (if available)

Paralogs for CRTC1 Gene

Paralogs for CRTC1 Gene

(2) SIMAP similar genes for CRTC1 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for CRTC1 Gene

genes like me logo Genes that share paralogs with CRTC1: view

Variants for CRTC1 Gene

Sequence variations from dbSNP and Humsavar for CRTC1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs3746266 -, - 18,765,499(-) CAGGG(C/T)GGGCG reference, missense
rs36070283 - 18,765,448(+) CTGGC(A/G)TCAGC reference, missense
rs757348 -- 18,699,985(+) GACTG(A/T)GCCTC intron-variant
rs757349 -- 18,700,066(+) GTTAA(A/G)TGGCT intron-variant
rs7256502 -- 18,736,055(+) TGGTT(C/T)TCAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CRTC1 Gene

Variant ID Type Subtype PubMed ID
nsv911282 CNV Loss 21882294
dgv3784n71 CNV Loss 21882294
esv2610416 CNV Insertion 19546169
nsv2431 CNV Insertion 18451855
nsv2433 CNV Insertion 18451855
esv999375 CNV Insertion 20482838
esv2674391 CNV Deletion 23128226
dgv3786n71 CNV Loss 21882294
nsv911295 CNV Loss 21882294
nsv911296 CNV Loss 21882294
nsv833777 CNV Loss 17160897

Variation tolerance for CRTC1 Gene

Residual Variation Intolerance Score: 6.04% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.53; 77.78% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CRTC1 Gene

Disorders for CRTC1 Gene

MalaCards: The human disease database

(11) MalaCards diseases for CRTC1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
mucoepidermoid carcinoma
  • mec
clear cell hidradenoma
  • eccrine acrospiroma
cutaneous mucoepidermoid carcinoma
  • mucoepidermoid carcinoma of skin
hidradenoma
  • hidradenoma morphology
lacrimal gland mucoepidermoid carcinoma
  • mucoepidermoid carcinoma of the lacrimal gland
- elite association - COSMIC cancer census association via MalaCards
Search CRTC1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

CRTC1_HUMAN
  • Note=A chromosomal aberration involving CRTC1 is found in mucoepidermoid carcinomas, benign Warthin tumors and clear cell hidradenomas. Translocation t(11;19)(q21;p13) with MAML2. The fusion protein consists of the N-terminus of CRTC1 joined to the C-terminus of MAML2. The reciprocal fusion protein consisting of the N-terminus of MAML2 joined to the C-terminus of CRTC1 has been detected in a small number of mucoepidermoid carcinomas.

Relevant External Links for CRTC1

Genetic Association Database (GAD)
CRTC1
Human Genome Epidemiology (HuGE) Navigator
CRTC1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CRTC1
genes like me logo Genes that share disorders with CRTC1: view

No data available for Genatlas for CRTC1 Gene

Publications for CRTC1 Gene

  1. Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells. (PMID: 14506290) Iourgenko V. … Labow M.A. (Proc. Natl. Acad. Sci. U.S.A. 2003) 2 3 4 23 67
  2. Prognostic significance of p27Kip1, Ki-67, and CRTC1-MAML2 fusion transcript in mucoepidermoid carcinoma: a molecular and clinicopathologic study of 101 cases. (PMID: 19531414) Miyabe S. … Inagaki H. (J. Oral Maxillofac. Surg. 2009) 3 23
  3. Frequent fusion of the CRTC1 and MAML2 genes in clear cell variants of cutaneous hidradenomas. (PMID: 17334997) Winnes M. … Stenman G. (Genes Chromosomes Cancer 2007) 3 23
  4. Activation of cAMP response element-mediated gene expression by regulated nuclear transport of TORC proteins. (PMID: 15589160) Bittinger M.A. … Labow M. (Curr. Biol. 2004) 3 23
  5. t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway. (PMID: 12539049) Tonon G. … Kaye F.J. (Nat. Genet. 2003) 2 3

Products for CRTC1 Gene

Sources for CRTC1 Gene

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