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Aliases for CRTC1 Gene

Aliases for CRTC1 Gene

  • CREB Regulated Transcription Coactivator 1 2 3
  • MECT1 3 4 6
  • Mucoepidermoid Carcinoma Translocated Protein 1 3 4
  • KIAA0616 4 6
  • TORC-1 3 4
  • WAMTP1 3 4
  • TORC1 3 4
  • Transducer Of Regulated CAMP Response Element-Binding Protein (CREB) 1 3
  • Transducer Of Regulated CAMP Response Element-Binding Protein 1 4
  • Transducer Of Regulated CAMP Response Element-Binding Protein 2
  • CREB-Regulated Transcription Coactivator 1 3
  • Mucoepidermoid Carcinoma Translocated 1 2
  • Transducer Of CREB Protein 1 4
  • FLJ14027 6

External Ids for CRTC1 Gene

Previous HGNC Symbols for CRTC1 Gene

  • MECT1

Previous GeneCards Identifiers for CRTC1 Gene

  • GC19P018794
  • GC19P018417

Summaries for CRTC1 Gene

GeneCards Summary for CRTC1 Gene

CRTC1 (CREB Regulated Transcription Coactivator 1) is a Protein Coding gene. Diseases associated with CRTC1 include clear cell hidradenoma and cutaneous mucoepidermoid carcinoma. Among its related pathways are Glucose / Energy Metabolism and HTLV-I infection. GO annotations related to this gene include cAMP response element binding protein binding. An important paralog of this gene is CRTC3.

UniProtKB/Swiss-Prot for CRTC1 Gene

  • Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 Ser-133 phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons (By similarity). In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock.

Gene Wiki entry for CRTC1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRTC1 Gene

Genomics for CRTC1 Gene

Regulatory Elements for CRTC1 Gene

Genomic Location for CRTC1 Gene

Start:
18,683,615 bp from pter
End:
18,782,333 bp from pter
Size:
98,719 bases
Orientation:
Plus strand

Genomic View for CRTC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CRTC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRTC1 Gene

Proteins for CRTC1 Gene

  • Protein details for CRTC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UUV9-CRTC1_HUMAN
    Recommended name:
    CREB-regulated transcription coactivator 1
    Protein Accession:
    Q6UUV9
    Secondary Accessions:
    • A6NMG5
    • O75114
    • Q6Y3A3
    • Q7LDZ2
    • Q8IUL3
    • Q8IZ34
    • Q8IZL1
    • Q8N6W3
    • Q96AI8
    • Q9H801

    Protein attributes for CRTC1 Gene

    Size:
    634 amino acids
    Molecular mass:
    67300 Da
    Quaternary structure:
    • Binds, as a tetramer, through its N-terminal region, with the bZIP domain of CREB1. Arg-314 in the bZIP domain of CREB1 is essential for this interaction. Interaction, via its C-terminal, with TAF4, enhances recruitment of TAF4 to CREB1. Binds HTLV1 Tax.
    SequenceCaution:
    • Sequence=AAH17075.3; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH23614.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAP12463.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CRTC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CRTC1 Gene

Proteomics data for CRTC1 Gene at MOPED

Post-translational modifications for CRTC1 Gene

  • Phosphorylation/dephosphorylation states of Ser-151 are required for regulating transduction of CREB activity. TORCs are inactive when phosphorylated, and active when dephosphorylated at this site. This primary site of phosphorylation is mediated by SIKs (SIK1 and SIK2), is regulated by cAMP and calcium levels and is dependent on the phosphorylation of SIKs by LKB1 (By similarity).
  • Ubiquitination at Lys47
  • Modification sites at PhosphoSitePlus

Other Protein References for CRTC1 Gene

No data available for DME Specific Peptides for CRTC1 Gene

Domains for CRTC1 Gene

Protein Domains for CRTC1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CRTC1 Gene

Graphical View of Domain Structure for InterPro Entry

Q6UUV9

UniProtKB/Swiss-Prot:

CRTC1_HUMAN :
  • Q6UUV9
Family:
  • Belongs to the TORC family.
genes like me logo Genes that share domains with CRTC1: view

No data available for Gene Families for CRTC1 Gene

Function for CRTC1 Gene

Molecular function for CRTC1 Gene

UniProtKB/Swiss-Prot Function: Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 Ser-133 phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons (By similarity). In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock.

Gene Ontology (GO) - Molecular Function for CRTC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14506290
GO:0008140 cAMP response element binding protein binding IDA 14536081
genes like me logo Genes that share ontologies with CRTC1: view
genes like me logo Genes that share phenotypes with CRTC1: view

miRNA for CRTC1 Gene

miRTarBase miRNAs that target CRTC1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CRTC1 Gene

Localization for CRTC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRTC1 Gene

Cytoplasm. Nucleus. Note=Cytoplasmic when phosphorylated by SIK or AMPK and when sequestered by 14-3-3 proteins (By similarity). Translocated to the nucleus on Ser-151 dephosphorylation, instigated by a number of factors including calcium ion and cAMP levels. Light stimulation triggers a nuclear accumulation in the suprachiasmatic nucleus (SCN) of the brain. {ECO:0000250 UniProtKB:Q68ED7}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CRTC1 Gene COMPARTMENTS Subcellular localization image for CRTC1 gene
Compartment Confidence
nucleus 5
golgi apparatus 4
plasma membrane 4
cytosol 3

Gene Ontology (GO) - Cellular Components for CRTC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 14506290
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with CRTC1: view

Pathways for CRTC1 Gene

genes like me logo Genes that share pathways with CRTC1: view

Pathways by source for CRTC1 Gene

1 Cell Signaling Technology pathway for CRTC1 Gene
1 BioSystems pathway for CRTC1 Gene
1 KEGG pathway for CRTC1 Gene

Gene Ontology (GO) - Biological Process for CRTC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0007613 memory IEA --
GO:0016032 viral process IEA --
GO:0032793 positive regulation of CREB transcription factor activity ISS --
GO:0043153 entrainment of circadian clock by photoperiod ISS --
genes like me logo Genes that share ontologies with CRTC1: view

Compounds for CRTC1 Gene

(2) HMDB Compounds for CRTC1 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Cyclic AMP
  • Cyclic AMP
60-92-4
genes like me logo Genes that share compounds with CRTC1: view

Transcripts for CRTC1 Gene

Unigene Clusters for CRTC1 Gene

CREB regulated transcription coactivator 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CRTC1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b
SP1:
SP2:
SP3: - - - -
SP4: -
SP5: - - -
SP6:

Relevant External Links for CRTC1 Gene

GeneLoc Exon Structure for
CRTC1
ECgene alternative splicing isoforms for
CRTC1

Expression for CRTC1 Gene

mRNA expression in normal human tissues for CRTC1 Gene

mRNA differential expression in normal tissues according to GTEx for CRTC1 Gene

This gene is overexpressed in Brain - Cerebellum (5.2) and Brain - Cerebellar Hemisphere (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CRTC1 Gene

SOURCE GeneReport for Unigene cluster for CRTC1 Gene Hs.371096

mRNA Expression by UniProt/SwissProt for CRTC1 Gene

Q6UUV9-CRTC1_HUMAN
Tissue specificity: Highly expressed in adult and fetal brain. Located to specific regions such as the prefrontal cortex and cerebellum. Very low expression in other tissues such as heart, spleen, lung, skeletal muscle, salivary gland, ovary and kidney.
genes like me logo Genes that share expressions with CRTC1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CRTC1 Gene

Orthologs for CRTC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CRTC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CRTC1 35
  • 99.37 (n)
  • 99.84 (a)
CRTC1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CRTC1 35
  • 91.46 (n)
  • 95.82 (a)
CRTC1 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 81 (a)
OneToMany
-- 36
  • 92 (a)
OneToMany
-- 36
  • 65 (a)
OneToMany
CRTC1 35
  • 90.02 (n)
  • 94.2 (a)
mouse
(Mus musculus)
Mammalia Crtc1 35
  • 85.27 (n)
  • 89.63 (a)
Crtc1 16
Crtc1 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CRTC1 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CRTC1 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Crtc1 35
  • 84.8 (n)
  • 89.31 (a)
chicken
(Gallus gallus)
Aves CRTC1 35
  • 78.11 (n)
  • 84.58 (a)
CRTC1 36
  • 82 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.12669 35
tropical clawed frog
(Silurana tropicalis)
Amphibia crtc1 35
  • 72.19 (n)
  • 82.45 (a)
zebrafish
(Danio rerio)
Actinopterygii crtc1a 36
  • 68 (a)
OneToOne
LOC101886240 35
  • 68.18 (n)
  • 69.28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4116 36
  • 39 (a)
OneToOne
Species with no ortholog for CRTC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CRTC1 Gene

ENSEMBL:
Gene Tree for CRTC1 (if available)
TreeFam:
Gene Tree for CRTC1 (if available)

Paralogs for CRTC1 Gene

Paralogs for CRTC1 Gene

Selected SIMAP similar genes for CRTC1 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for CRTC1 Gene

genes like me logo Genes that share paralogs with CRTC1: view

Variants for CRTC1 Gene

Sequence variations from dbSNP and Humsavar for CRTC1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs10038 -- 18,781,918(+) CCCAG(A/C)CATCA utr-variant-3-prime
rs419646 -- 18,698,049(+) TGCAC(A/G)GTGTG intron-variant
rs419896 -- 18,698,181(+) ACTCA(C/G)CAGGC intron-variant
rs434469 -- 18,698,366(+) TCAGC(A/T)GGTGC intron-variant
rs434487 -- 18,698,399(+) TCAGC(A/T)GGCGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CRTC1 Gene

Variant ID Type Subtype PubMed ID
nsv911282 CNV Loss 21882294
dgv3784n71 CNV Loss 21882294
esv2610416 CNV Insertion 19546169
nsv2431 CNV Insertion 18451855
nsv2433 CNV Insertion 18451855
esv999375 CNV Insertion 20482838
esv2674391 CNV Deletion 23128226
dgv3786n71 CNV Loss 21882294
nsv911295 CNV Loss 21882294
nsv911296 CNV Loss 21882294
nsv833777 CNV Loss 17160897

Relevant External Links for CRTC1 Gene

HapMap Linkage Disequilibrium report
CRTC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRTC1 Gene

Disorders for CRTC1 Gene

UniProtKB/Swiss-Prot

CRTC1_HUMAN
  • Note=A chromosomal aberration involving CRTC1 is found in mucoepidermoid carcinomas, benign Warthin tumors and clear cell hidradenomas. Translocation t(11;19)(q21;p13) with MAML2. The fusion protein consists of the N-terminus of CRTC1 joined to the C-terminus of MAML2. The reciprocal fusion protein consisting of the N-terminus of MAML2 joined to the C-terminus of CRTC1 has been detected in a small number of mucoepidermoid carcinomas.

(1) Novoseek inferred disease relationships for CRTC1 Gene

Disease -log(P) Hits PubMed IDs
carcinoma mucoepidermoid 80.9 2

Relevant External Links for CRTC1

Genetic Association Database (GAD)
CRTC1
Human Genome Epidemiology (HuGE) Navigator
CRTC1
genes like me logo Genes that share disorders with CRTC1: view

Publications for CRTC1 Gene

  1. Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells. (PMID: 14506290) Iourgenko V. … Labow M.A. (Proc. Natl. Acad. Sci. U.S.A. 2003) 2 3 4 23
  2. Activation of cAMP response element-mediated gene expression by regulated nuclear transport of TORC proteins. (PMID: 15589160) Bittinger M.A. … Labow M. (Curr. Biol. 2004) 3 4 23
  3. t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway. (PMID: 12539049) Tonon G. … Kaye F.J. (Nat. Genet. 2003) 2 3 4
  4. TORCs: transducers of regulated CREB activity. (PMID: 14536081) Conkright M.D. … Montminy M. (Mol. Cell 2003) 2 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for CRTC1 Gene

  • Addgene plasmids for CRTC1

Sources for CRTC1 Gene

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