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CRTAM Gene

protein-coding   GIFtS: 51
GCID: GC11P122743

Cytotoxic And Regulatory T Cell Molecule

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cytotoxic And Regulatory T Cell Molecule1 2     Class-I MHC-Restricted T Cell Associated Molecule2
Class I MHC Restricted T Cell Associated Molecule1 2     Cytotoxic And Regulatory T-Cell Molecule2
Class-I MHC-Restricted T-Cell-Associated Molecule2 3     CD355 Antigen3
CD3552     

External Ids:    HGNC: 243131   Entrez Gene: 562532   Ensembl: ENSG000001099437   OMIM: 6125975   UniProtKB: O957273   

Export aliases for CRTAM gene to outside databases

Previous GC identifers: GC11P124710 GC11P124222 GC11P122246 GC11P122214 GC11P118652


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CRTAM Gene:
The CRTAM gene is upregulated in CD4 (see MIM 186940)-positive and CD8 (see CD8A; MIM 186910)-positive T cells and
encodes a type I transmembrane protein with V and C1-like Ig domains (Yeh et al., 2008 (PubMed
18329370)).(supplied by OMIM, Feb 2009)

GeneCards Summary for CRTAM Gene:
CRTAM (cytotoxic and regulatory T cell molecule) is a protein-coding gene. GO annotations related to this gene include receptor binding. An important paralog of this gene is CADM4.

UniProtKB/Swiss-Prot: CRTAM_HUMAN, O95727
Function: Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma)
secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_033899.9  
Regulatory elements:
   Regulatory transcription factor binding sites in the CRTAM gene promoter:
         AML1a   Nkx2-5   IRF-1   NF-kappaB   RORalpha1   IRF-2   NF-kappaB2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCRTAM promoter sequence
   Search Chromatin IP Primers for CRTAM

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CRTAM


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q24.1   Ensembl cytogenetic band:  11q24.1   HGNC cytogenetic band: 11q24.1

CRTAM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRTAM gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P122743:  view genomic region     (about GC identifiers)

Start:
122,709,208 bp from pter      End:
122,743,347 bp from pter
Size:
34,140 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CRTAM_HUMAN, O95727 (See protein sequence)
Recommended Name: Cytotoxic and regulatory T-cell molecule precursor  
Size: 393 amino acids; 44641 Da
Subunit: Interacts with CADM1
Sequence caution: Sequence=BAD93067.1; Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for CRTAM:
3RBG (3D)        4H5S (3D)    
Secondary accessions: Q59EI1 Q6IRX2
Alternative splicing: 2 isoforms:  O95727-1   O95727-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CRTAM: NX_O95727

Explore proteomics data for CRTAM at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn21, Asn87, Asn178

  • See CRTAM Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_062550.2  
    ENSEMBL proteins: 
     ENSP00000227348   ENSP00000433728  
    Reactome Protein details: O95727

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    C2SET: Immunoglobulin superfamily / C2-set domain containing
    CD: CD molecules
    VSET: Immunoglobulin superfamily / V-set domain containing

    5 InterPro protein domains:
     IPR013162 CD80_C2-set
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry O95727

    ProtoNet protein and cluster: O95727

    UniProtKB/Swiss-Prot: CRTAM_HUMAN, O95727
    Similarity: Belongs to the nectin family
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    Find genes that share domains with CRTAM           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CRTAM_HUMAN, O95727
    Function: Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma)
    secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding IPI15811952
    GO:0005515protein binding ----
         
    Find genes that share ontologies with CRTAM           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Crtam):
     hematopoietic system  immune system 

    Find genes that share phenotypes with CRTAM           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CRTAM: Crtamtm1Tks Crtamtm1Achn

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CRTAM
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    hsa-mir-335-5p (MIRT018919), hsa-mir-26b-5p (MIRT030104)

    Block miRNA regulation of human, mouse, rat CRTAM using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CRTAM (see all 17):
    hsa-miR-345 hsa-miR-142-3p hsa-miR-539 hsa-miR-1197 hsa-miR-25 hsa-miR-133a hsa-miR-4325 hsa-miR-33b
    SwitchGear 3'UTR luciferase reporter plasmidCRTAM 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CRTAM_HUMAN, O95727: Membrane; Single-pass type I membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    peroxisome2
    cytosol1
    extracellular1
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with CRTAM           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CRTAM About    
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Adaptive Immune System0.41
    2Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell


    Find genes that share SuperPaths with CRTAM           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for CRTAM
        Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CRTAM
    Interactions:

        GeneGlobe Interaction Network for CRTAM

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for CRTAM (O957273 ENSP000002273484) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SCRIBQ141603, ENSP000003494864I2D: score=1 STRING: ENSP00000349486
    LRRC1ENSP000003599254STRING: ENSP00000359925
    DLG1ENSP000003457314STRING: ENSP00000345731
    DLG2ENSP000003652724STRING: ENSP00000365272
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001913NOT T cell mediated cytotoxicity IDA15811952
    GO:0002355detection of tumor cell IDA15811952
    GO:0002860positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IDA15811952
    GO:0008037cell recognition IDA15811952
    GO:0045954positive regulation of natural killer cell mediated cytotoxicity IDA15811952

    Find genes that share ontologies with CRTAM           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CRTAM



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CRTAM gene: 
    NM_019604.2  

    Unigene Cluster for CRTAM:

    Cytotoxic and regulatory T cell molecule
    Hs.159523  [show with all ESTs]
    Unigene Representative Sequence: BC070266
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000227348(uc001pyj.3) ENST00000533709(uc001pyk.3) ENST00000533416

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    Selected qRT-PCR Assays for microRNAs that regulate CRTAM (see all 17):
    hsa-miR-345 hsa-miR-142-3p hsa-miR-539 hsa-miR-1197 hsa-miR-25 hsa-miR-133a hsa-miR-4325 hsa-miR-33b
    SwitchGear 3'UTR luciferase reporter plasmidCRTAM 3' UTR sequence
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      QuantiFast Probe-based Assays in human, mouse, rat CRTAM

    Additional mRNA sequence: 

    AB209830.1 AF001622.1 AK293470.1 AK313578.1 BC070266.1 

    2 DOTS entries:

    DT.424789  DT.100764176 

    Selected AceView cDNA sequences (see all 26):

    AA322525 BG058725 AW137831 CD365583 BX488905 CD640439 BM919441 NM_019604 
    BF445107 AA322787 BX488047 CA309993 BC070266 CD639624 AF001622 BX118379 
    CD641796 BF434560 CD640427 CD642037 AI693616 BG205621 CK004240 BG231751 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CRTAM expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTTTCTTTT
    CRTAM Expression
    About this image


    CRTAM expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             T-Cytotoxic Cells Peripheral Blood
     
     Thymus (Hematopoietic System)
             T-Cytotoxic Cells Thymus
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
    CRTAM Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CRTAM Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.159523

    UniProtKB/Swiss-Prot: CRTAM_HUMAN, O95727
    Tissue specificity: In the immune system, expression is restricted to activated class-I MHC-restricted cells,
    including NKT and CD8 cells. Strongly expressed in spleen, thymus, small intestine, peripheral blood leukocyte,
    and in Purkinje neurons in cerebellum. Expressed at much lower levels in testis, ovary, colon, lung and lymphoid
    tissues

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CRTAM gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Crtam1 , 5 cytotoxic and regulatory T cell molecule1, 5 77.46(n)1
    72.24(a)1
      9 (21.79 cM)5
    546981  NM_001281954.11  NP_001268883.11 
     409727535 
    chicken
    (Gallus gallus)
    Aves CRTAM1 cytotoxic and regulatory T cell molecule 56.29(n)
    43.88(a)
      395342  NM_001030347.1  NP_001025518.1 
    lizard
    (Anolis carolinensis)
    Reptilia CRTAM6
    cytotoxic and regulatory T cell molecule
    35(a)
    1 ↔ 1
    LGa(2896884-2916250)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1018842191 cytotoxic and regulatory T-cell molecule-like 47.12(n)
    37.18(a)
      101884219  XM_005172707.1  XP_005172764.1 


    ENSEMBL Gene Tree for CRTAM (if available)
    TreeFam Gene Tree for CRTAM (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CRTAM gene
    CADM42  CADM32  CADM12  CADM22  

    Find genes that share paralogs with CRTAM           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CRTAM (see all 852)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1394347641,2
    C--122707317(+) TGAGA-/CCCCCC 1 -- us2k10--------
    rs1872683361,2
    --122707337(+) CCCTAA/TGGAGG 1 -- us2k10--------
    rs107905391,2
    C,F,A,H--122707408(+) CCTGGA/GTGGAA 1 -- us2k123Minor allele frequency- G:0.39NS EA NA CSA WA 2747
    rs1920231671,2
    --122707553(+) GATCAC/TGGCTC 1 -- us2k10--------
    rs1825477371,2
    --122707554(+) ATCACA/GGCTCA 1 -- us2k10--------
    rs561713021,2
    C,F--122707777(+) CACTGC/TGCCCA 1 -- us2k12Minor allele frequency- T:0.50WA 4
    rs1395196821,2
    --122707799(+) ATTTGA/GAAGAC 1 -- us2k10--------
    rs112188561,2
    C,F,A,H--122707889(+) GTAAGC/TAGTGT 1 -- us2k127Minor allele frequency- N:0.00NS EA NA CSA WA 2975
    rs1435299691,2
    --122707919(+) CATTGC/TAGACT 1 -- us2k10--------
    rs1471332561,2
    C--122707947(+) CATAAA/GCTTAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CRTAM (122709208 - 122743347 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CRTAM:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv520988CNV Gain19592680
    nsv898433CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CRTAM
    DNA2.0 Custom Variant and Variant Library Synthesis for CRTAM

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612597    OMIM disorders: --


    Find genes that share disorders with CRTAM           About GenesLikeMe


    Export disorders for CRTAM gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CRTAM gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with CRTAM)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human class-I restricted T cell associated molecule is highly expressed in the cerebellum and is a marker for activated NKT and CD8+ T lymphocytes. (PubMed id 16300832)1, 2, 3 Patino-Lopez G.... Zlotnik A. (J. Neuroimmunol. 2006)
    2. A molecular analysis of NKT cells: identification of a class-I restricted T cell-associated molecule (CRTAM). (PubMed id 10811014)1, 2, 3 Kennedy J.... Zlotnik A. (J. Leukoc. Biol. 2000)
    3. Nectin-like protein 2 defines a subset of T-cell zone dendritic cells and is a ligand for class-I-restricted T-cell-associated molecule. (PubMed id 15781451)1, 2 Galibert L.... Yan W. (J. Biol. Chem. 2005)
    4. The tumor suppressor TSLC1/NECL-2 triggers NK-cell and CD8+ T-cell responses through the cell-surface receptor CRTAM. (PubMed id 15811952)1, 2 Boles K.S.... Colonna M. (Blood 2005)
    5. Characterization of CRTAM gene promoter: AP-1 transcription factor control its expression in human T CD8 lymphocytes. (PubMed id 19695707)1, 9 Valle-Rios R....Ortiz-Navarrete V. (Mol. Immunol. 2009)
    6. Competition of cell adhesion and immune recognition: insights into the interaction between CRTAM and nectin-like 2. (PubMed id 23871486)1 Zhang S....Gao G.F. (Structure 2013)
    7. CRTAM receptor engagement by Necl-2 on tumor cells triggers cell death of activated VI^9VI'2 T cells. (PubMed id 23530148)1 Dessarthe B....Toutirais O. (J. Immunol. 2013)
    8. Genome-wide association study reveals class I MHC-restricted T cell-associated molecule gene (CRTAM) variants interact with vitamin D levels to affect asthma exacerbations. (PubMed id 22051697)1 Du R....Weiss S.T. (J. Allergy Clin. Immunol. 2012)
    9. CRTAM: A molecule involved in epithelial cell adhesion. (PubMed id 20556794)1 Garay E....GonzA!lez-Mariscal L. (J. Cell. Biochem. 2010)
    10. Regulation of a late phase of T cell polarity and effector functions by Crtam. (PubMed id 18329370)1 Yeh J.H....Chan A.C. (Cell 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 56253 HGNC: 24313 AceView: CRTAM Ensembl:ENSG00000109943 euGenes: HUgn56253
    ECgene: CRTAM H-InvDB: CRTAM

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CRTAM Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    Patent Information for CRTAM gene:
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