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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CRTAM Gene

protein-coding   GIFtS: 51
GCID: GC11P122743

Cytotoxic And Regulatory T Cell Molecule

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cytotoxic And Regulatory T Cell Molecule1 2     Class-I MHC-Restricted T Cell Associated Molecule2
Class I MHC Restricted T Cell Associated Molecule1 2     Cytotoxic And Regulatory T-Cell Molecule2
Class-I MHC-Restricted T-Cell-Associated Molecule2 3     CD355 Antigen3
CD3552     

External Ids:    HGNC: 243131   Entrez Gene: 562532   Ensembl: ENSG000001099437   OMIM: 6125975   UniProtKB: O957273   

Export aliases for CRTAM gene to outside databases

Previous GC identifers: GC11P124710 GC11P124222 GC11P122246 GC11P122214 GC11P118652


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CRTAM Gene:
The CRTAM gene is upregulated in CD4 (see MIM 186940)-positive and CD8 (see CD8A; MIM 186910)-positive T cells and
encodes a type I transmembrane protein with V and C1-like Ig domains (Yeh et al., 2008 (PubMed
18329370)).(supplied by OMIM, Feb 2009)

GeneCards Summary for CRTAM Gene: 
CRTAM (cytotoxic and regulatory T cell molecule) is a protein-coding gene. Diseases associated with CRTAM include asthma, and neuronitis, and among its related super-pathways are Immune System and FCGR activation. GO annotations related to this gene include receptor binding. An important paralog of this gene is CADM4.

UniProtKB/Swiss-Prot: CRTAM_HUMAN, O95727
Function: Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma)
secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_033899.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CRTAM gene promoter:
         AML1a   Nkx2-5   IRF-1   NF-kappaB   RORalpha1   IRF-2   NF-kappaB2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCRTAM promoter sequence
   Search SABiosciences Chromatin IP Primers for CRTAM

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CRTAM


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q24.1   Ensembl cytogenetic band:  11q24.1   HGNC cytogenetic band: 11q24.1

CRTAM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRTAM gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P122743:  view genomic region     (about GC identifiers)

Start:
122,709,208 bp from pter      End:
122,743,347 bp from pter
Size:
34,140 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CRTAM_HUMAN, O95727 (See protein sequence)
Recommended Name: Cytotoxic and regulatory T-cell molecule precursor  
Size: 393 amino acids; 44641 Da
Subunit: Interacts with CADM1
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Sequence caution: Sequence=BAD93067.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for CRTAM:
3RBG (3D)    
Secondary accessions: Q59EI1 Q6IRX2
Alternative splicing: 2 isoforms:  O95727-1   O95727-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CRTAM: NX_O95727

Explore proteomics data for CRTAM at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O95727

  • CRTAM Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CRTAM Protein Expression
    REFSEQ proteins: NP_062550.2  
    ENSEMBL proteins: 
     ENSP00000227348   ENSP00000433728  
    Reactome Protein details: O95727
    Human Recombinant Protein Products for CRTAM: 
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    OriGene Protein Over-expression Lysate for CRTAM
    OriGene Custom MassSpec 
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    Novus Biologicals CRTAM Proteins
    Novus Biologicals CRTAM Lysates
    Sino Biological Recombinant Protein for CRTAM
    Sino Biological Cell Lysate for CRTAM 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CRTAM 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IEA--

    CRTAM for ontologies           About GeneDecksing



    CRTAM Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for CRTAM 

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    Cloud-Clone Corp. ELISAs for CRTAM 
    Cloud-Clone Corp. CLIAs for CRTAM


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    C2SET: Immunoglobulin superfamily / C2-set domain containing
    CD: CD molecules
    VSET: Immunoglobulin superfamily / V-set domain containing

    5 InterPro protein domains:
     IPR013162 CD80_C2-set
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry O95727

    ProtoNet protein and cluster: O95727

    UniProtKB/Swiss-Prot: CRTAM_HUMAN, O95727
    Similarity: Belongs to the nectin family
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    CRTAM for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CRTAM_HUMAN, O95727
    Function: Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma)
    secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding IPI15811952
    GO:0005515protein binding ----
         
    CRTAM for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Crtam):
     cellular  hematopoietic system  immune system 

    CRTAM for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CRTAM: Crtamtm1Tks Crtamtm1Achn

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CRTAM 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CRTAM 
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    miRNA
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    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate CRTAM (see all 17):
    hsa-miR-345 hsa-miR-142-3p hsa-miR-539 hsa-miR-1197 hsa-miR-25 hsa-miR-133a hsa-miR-4325 hsa-miR-33b
    SwitchGear 3'UTR luciferase reporter plasmidCRTAM 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CRTAM About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Immune System
    Immune System0.56
    Adaptive Immune System0.56
    2Classical antibody-mediated complement activation
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell0.30

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    3        Reactome Pathways for CRTAM
        Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Adaptive Immune System
    Immune System



    CRTAM for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CRTAM

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for CRTAM (O957273 ENSP000002273484) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SCRIBQ141603, ENSP000003494864I2D: score=1 STRING: ENSP00000349486
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001913NOT T cell mediated cytotoxicity IDA15811952
    GO:0002355detection of tumor cell IDA15811952
    GO:0002860positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IDA15811952
    GO:0008037cell recognition IDA15811952
    GO:0045954positive regulation of natural killer cell mediated cytotoxicity IDA15811952

    CRTAM for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CRTAM

    Search CenterWatch for drugs/clinical trials and news about CRTAM

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CRTAM gene: 
    NM_019604.2  

    Unigene Cluster for CRTAM:

    Cytotoxic and regulatory T cell molecule
    Hs.159523  [show with all ESTs]
    Unigene Representative Sequence: BC070266
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000227348(uc001pyj.3) ENST00000533709(uc001pyk.3) ENST00000533416

    miRNA
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    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate CRTAM (see all 17):
    hsa-miR-345 hsa-miR-142-3p hsa-miR-539 hsa-miR-1197 hsa-miR-25 hsa-miR-133a hsa-miR-4325 hsa-miR-33b
    SwitchGear 3'UTR luciferase reporter plasmidCRTAM 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CRTAM
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CRTAM
    Clone
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    Sirion Biotech Customized lentivirus for stable overexpression of CRTAM 
                         Customized lentivirus expression plasmids for stable overexpression of CRTAM 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CRTAM
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRTAM

    Additional mRNA sequence: 

    AB209830.1 AF001622.1 AK293470.1 AK313578.1 BC070266.1 

    2 DOTS entries:

    DT.424789  DT.100764176 

    24/26 AceView cDNA sequences (see all 26):

    AA322525 CD641796 AF001622 AW137831 BX118379 CD640439 BX488905 BX488047 
    BF434560 NM_019604 CD639624 BC070266 AA322787 BF445107 CA309993 CD365583 
    BM919441 BG058725 BG231751 CD642037 CD640427 AI693616 BG205621 CK004240 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CRTAM expression in normal human tissues (normalized intensities)      CRTAM embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTTTCTTTT
    CRTAM Expression
    About this image


    CRTAM expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/31 selected tissues (see all 31) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
             cerebellum   
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Blood (Cardiovascular System)    fully expand to see all 4 entries
             T-Cytotoxic Cells Thymus
             lung ; macrophages   
             cd8+ t cell   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   

    See CRTAM Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CRTAM

    SOURCE GeneReport for Unigene cluster: Hs.159523

    UniProtKB/Swiss-Prot: CRTAM_HUMAN, O95727
    Tissue specificity: In the immune system, expression is restricted to activated class-I MHC-restricted cells,
    including NKT and CD8 cells. Strongly expressed in spleen, thymus, small intestine, peripheral blood leukocyte,
    and in Purkinje neurons in cerebellum. Expressed at much lower levels in testis, ovary, colon, lung and lymphoid
    tissues

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CRTAM gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Crtam1 , 5 cytotoxic and regulatory T cell molecule1, 5 77.41(n)1
    72.16(a)1
      9 (21.79 cM)5
    546981  NM_019465.31  NP_062338.31 
     409727535 
    chicken
    (Gallus gallus)
    Aves CRTAM1 cytotoxic and regulatory T cell molecule 56.93(n)
    44.1(a)
      395342  NM_001030347.1  NP_001025518.1 
    lizard
    (Anolis carolinensis)
    Reptilia CRTAM6
    cytotoxic and regulatory T cell molecule
    35(a)
    1 ↔ 1
    LGa(2896884-2916250)
    zebrafish
    (Danio rerio)
    Actinopterygii BX120005.16
    Uncharacterized protein
    23(a)
    1 ↔ 1
    10(30748495-30755897)


    ENSEMBL Gene Tree for CRTAM (if available)
    TreeFam Gene Tree for CRTAM (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CRTAM gene
    CADM42  CADM32  CADM12  CADM22  

    CRTAM for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/852 SNPs in CRTAM are shown (see all 852)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1394347641,2
    C--122707317(+) TGAGA-/CCCCCC 1 -- us2k10--------
    rs1872683361,2
    --122707337(+) CCCTAA/TGGAGG 1 -- us2k10--------
    rs107905391,2
    C,F,A,H--122707408(+) CCTGGA/GTGGAA 1 -- us2k123Minor allele frequency- G:0.39NS EA NA CSA WA 2747
    rs1920231671,2
    --122707553(+) GATCAC/TGGCTC 1 -- us2k10--------
    rs1825477371,2
    --122707554(+) ATCACA/GGCTCA 1 -- us2k10--------
    rs561713021,2
    C,F--122707777(+) CACTGC/TGCCCA 1 -- us2k12Minor allele frequency- T:0.50WA 4
    rs1395196821,2
    --122707799(+) ATTTGA/GAAGAC 1 -- us2k10--------
    rs112188561,2
    C,F,A,H--122707889(+) GTAAGC/TAGTGT 1 -- us2k127Minor allele frequency- N:0.00NS EA NA CSA WA 2975
    rs1435299691,2
    --122707919(+) CATTGC/TAGACT 1 -- us2k10--------
    rs1471332561,2
    C--122707947(+) CATAAA/GCTTAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CRTAM (122709208 - 122743347 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CRTAM:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv520988CNV Gain19592680
    nsv898433CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CRTAM
    DNA2.0 Custom Variant and Variant Library Synthesis for CRTAM

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612597    OMIM disorders: --

    2 diseases for CRTAM:    About MalaCards
    asthma    neuronitis


    CRTAM for disorders           About GeneDecksing


    Export disorders for CRTAM gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CRTAM gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with CRTAM)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human class-I restricted T cell associated molecule is highly expressed in the cerebellum and is a marker for activated NKT and CD8+ T lymphocytes. (PubMed id 16300832)1, 2, 3 Patino-Lopez G.... Zlotnik A. (2006)
    2. A molecular analysis of NKT cells: identification of a class-I restricted T cell-associated molecule (CRTAM). (PubMed id 10811014)1, 2, 3 Kennedy J.... Zlotnik A. (2000)
    3. Nectin-like protein 2 defines a subset of T-cell zone dendritic cells and is a ligand for class-I-restricted T-cell-associated molecule. (PubMed id 15781451)1, 2 Galibert L.... Yan W. (2005)
    4. The tumor suppressor TSLC1/NECL-2 triggers NK-cell and CD8+ T-cell responses through the cell-surface receptor CRTAM. (PubMed id 15811952)1, 2 Boles K.S.... Colonna M. (2005)
    5. Characterization of CRTAM gene promoter: AP-1 transcr iption factor control its expression in human T CD8 lymphocytes. (PubMed id 19695707)1, 9 Valle-Rios R....Ortiz-Navarrete V. (2009)
    6. CRTAM receptor engagement by Necl-2 on tumor cells tri ggers cell death of activated Vg9Vd2 T cells. (PubMed id 23530148)1 Dessarthe B....Toutirais O. (2013)
    7. Genome-wide association study reveals class I MHC-rest ricted T cell-associated molecule gene (CRTAM) variants interact with vitamin D levels to affect asthma exacerbations. (PubMed id 22051697)1 Du R....Weiss S.T. (2012)
    8. CRTAM: A molecule involved in epithelial cell adhesio n. (PubMed id 20556794)1 Garay E....GonzA!lez-Mariscal L. (2010)
    9. Regulation of a late phase of T cell polarity and effector functions by Crtam. (PubMed id 18329370)1 Yeh J.H....Chan A.C. (2008)
    10. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 56253 HGNC: 24313 AceView: CRTAM Ensembl:ENSG00000109943 euGenes: HUgn56253
    ECgene: CRTAM H-InvDB: CRTAM

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    About This Section
    NameDescription
    PharmGKB entry for CRTAM Pharmacogenomics, SNPs, Pathways

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