Aliases for CRTAM Gene
External Ids for CRTAM Gene
Previous GeneCards Identifiers for CRTAM Gene
The CRTAM gene is upregulated in CD4 (see MIM 186940)-positive and CD8 (see CD8A; MIM 186910)-positive T cells and encodes a type I transmembrane protein with V and C1-like Ig domains (Yeh et al., 2008 [PubMed 18329370]).[supplied by OMIM, Feb 2009]
GeneCards Summary for CRTAM Gene
CRTAM (Cytotoxic And Regulatory T-Cell Molecule) is a Protein Coding gene. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Natural Killer Cell Receptors: Human Target Cell – NK Cell Ligand-Receptor Interactions. GO annotations related to this gene include receptor binding. An important paralog of this gene is CADM3.
UniProtKB/Swiss-Prot for CRTAM Gene
Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo.