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Aliases for CRTAM Gene

Aliases for CRTAM Gene

  • Cytotoxic And Regulatory T Cell Molecule 2 3
  • Class I MHC Restricted T Cell Associated Molecule 2 3
  • Class-I MHC-Restricted T-Cell-Associated Molecule 3 4
  • Class-I MHC-Restricted T Cell Associated Molecule 3
  • Cytotoxic And Regulatory T-Cell Molecule 3
  • CD355 Antigen 4
  • CD355 3

External Ids for CRTAM Gene

Previous GeneCards Identifiers for CRTAM Gene

  • GC11P124710
  • GC11P124222
  • GC11P122246
  • GC11P122214
  • GC11P118652

Summaries for CRTAM Gene

Entrez Gene Summary for CRTAM Gene

  • The CRTAM gene is upregulated in CD4 (see MIM 186940)-positive and CD8 (see CD8A; MIM 186910)-positive T cells and encodes a type I transmembrane protein with V and C1-like Ig domains (Yeh et al., 2008 [PubMed 18329370]).[supplied by OMIM, Feb 2009]

GeneCards Summary for CRTAM Gene

CRTAM (Cytotoxic And Regulatory T Cell Molecule) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. GO annotations related to this gene include receptor binding. An important paralog of this gene is CADM3.

UniProtKB/Swiss-Prot for CRTAM Gene

  • Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRTAM Gene

Genomics for CRTAM Gene

Regulatory Elements for CRTAM Gene

Genomic Location for CRTAM Gene

Start:
122,838,500 bp from pter
End:
122,872,639 bp from pter
Size:
34,140 bases
Orientation:
Plus strand

Genomic View for CRTAM Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CRTAM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRTAM Gene

Proteins for CRTAM Gene

  • Protein details for CRTAM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95727-CRTAM_HUMAN
    Recommended name:
    Cytotoxic and regulatory T-cell molecule
    Protein Accession:
    O95727
    Secondary Accessions:
    • Q59EI1
    • Q6IRX2

    Protein attributes for CRTAM Gene

    Size:
    393 amino acids
    Molecular mass:
    44641 Da
    Quaternary structure:
    • Interacts with CADM1.
    SequenceCaution:
    • Sequence=BAD93067.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CRTAM Gene

    Alternative splice isoforms for CRTAM Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CRTAM Gene

Proteomics data for CRTAM Gene at MOPED

Post-translational modifications for CRTAM Gene

  • Glycosylation at Asn21, Asn87, and Asn178
  • Modification sites at PhosphoSitePlus

Other Protein References for CRTAM Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CRTAM Gene

Domains for CRTAM Gene

Gene Families for CRTAM Gene

HGNC:
  • C2SET :Immunoglobulin superfamily / C2-set domain containing
  • CD :CD molecules
  • VSET :Immunoglobulin superfamily / V-set domain containing

Protein Domains for CRTAM Gene

Suggested Antigen Peptide Sequences for CRTAM Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95727

UniProtKB/Swiss-Prot:

CRTAM_HUMAN :
  • O95727
Domain:
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Family:
  • Belongs to the nectin family.
genes like me logo Genes that share domains with CRTAM: view

Function for CRTAM Gene

Molecular function for CRTAM Gene

UniProtKB/Swiss-Prot Function: Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo.

Gene Ontology (GO) - Molecular Function for CRTAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IPI 15811952
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with CRTAM: view

Phenotypes for CRTAM Gene

genes like me logo Genes that share phenotypes with CRTAM: view

Animal Models for CRTAM Gene

MGI Knock Outs for CRTAM:

miRNA for CRTAM Gene

miRTarBase miRNAs that target CRTAM

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CRTAM Gene

Localization for CRTAM Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRTAM Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CRTAM Gene COMPARTMENTS Subcellular localization image for CRTAM gene
Compartment Confidence
plasma membrane 4
peroxisome 2
cytosol 1
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CRTAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CRTAM: view

Pathways for CRTAM Gene

genes like me logo Genes that share pathways with CRTAM: view

Pathways by source for CRTAM Gene

Gene Ontology (GO) - Biological Process for CRTAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001913 NOT T cell mediated cytotoxicity IDA 15811952
GO:0002355 detection of tumor cell IDA 15811952
GO:0002860 positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IDA 15811952
GO:0008037 cell recognition IDA 15811952
GO:0045954 positive regulation of natural killer cell mediated cytotoxicity IDA 15811952
genes like me logo Genes that share ontologies with CRTAM: view

Transcripts for CRTAM Gene

Unigene Clusters for CRTAM Gene

Cytotoxic and regulatory T cell molecule:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CRTAM Gene

No ASD Table

Relevant External Links for CRTAM Gene

GeneLoc Exon Structure for
CRTAM
ECgene alternative splicing isoforms for
CRTAM

Expression for CRTAM Gene

mRNA expression in normal human tissues for CRTAM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CRTAM Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (26.3) and Brain - Cerebellum (22.3).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CRTAM Gene

SOURCE GeneReport for Unigene cluster for CRTAM Gene Hs.159523

mRNA Expression by UniProt/SwissProt for CRTAM Gene

O95727-CRTAM_HUMAN
Tissue specificity: In the immune system, expression is restricted to activated class-I MHC-restricted cells, including NKT and CD8 cells. Strongly expressed in spleen, thymus, small intestine, peripheral blood leukocyte, and in Purkinje neurons in cerebellum. Expressed at much lower levels in testis, ovary, colon, lung and lymphoid tissues.
genes like me logo Genes that share expressions with CRTAM: view

Orthologs for CRTAM Gene

This gene was present in the common ancestor of chordates.

Orthologs for CRTAM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CRTAM 35
  • 99.07 (n)
  • 98.98 (a)
CRTAM 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CRTAM 35
  • 83.5 (n)
  • 76.15 (a)
CRTAM 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CRTAM 35
  • 84.9 (n)
  • 78.63 (a)
CRTAM 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Crtam 35
  • 77.46 (n)
  • 72.24 (a)
Crtam 16
Crtam 36
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CRTAM 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CRTAM 36
  • 53 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Crtam 35
  • 75.45 (n)
  • 68.79 (a)
chicken
(Gallus gallus)
Aves CRTAM 35
  • 56.29 (n)
  • 43.88 (a)
CRTAM 36
  • 37 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CRTAM 36
  • 35 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii BX120005.1 36
  • 26 (a)
OneToOne
LOC101884219 35
  • 47.12 (n)
  • 37.18 (a)
Species with no ortholog for CRTAM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CRTAM Gene

ENSEMBL:
Gene Tree for CRTAM (if available)
TreeFam:
Gene Tree for CRTAM (if available)

Paralogs for CRTAM Gene

Paralogs for CRTAM Gene

genes like me logo Genes that share paralogs with CRTAM: view

Variants for CRTAM Gene

Sequence variations from dbSNP and Humsavar for CRTAM Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1879882 -- 122,847,982(+) GCAGC(A/T)GAGAG intron-variant
rs1879883 -- 122,839,933(-) CCTTA(C/T)TAAGT intron-variant
rs1879884 -- 122,839,853(-) ATGTA(A/C)AATAG intron-variant
rs1916036 - 122,871,320(+) AGAAG(C/G)AAAAA reference, missense
rs1916040 -- 122,863,109(+) TTCCA(A/G)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CRTAM Gene

Variant ID Type Subtype PubMed ID
nsv898433 CNV Gain 21882294
nsv520988 CNV Gain 19592680

Relevant External Links for CRTAM Gene

HapMap Linkage Disequilibrium report
CRTAM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRTAM Gene

Disorders for CRTAM Gene

No disorders were found for CRTAM Gene.

No data available for UniProtKB/Swiss-Prot for CRTAM Gene

Publications for CRTAM Gene

  1. Human class-I restricted T cell associated molecule is highly expressed in the cerebellum and is a marker for activated NKT and CD8+ T lymphocytes. (PMID: 16300832) Patino-Lopez G. … Zlotnik A. (J. Neuroimmunol. 2006) 2 3 4
  2. A molecular analysis of NKT cells: identification of a class-I restricted T cell-associated molecule (CRTAM). (PMID: 10811014) Kennedy J. … Zlotnik A. (J. Leukoc. Biol. 2000) 2 3 4
  3. Nectin-like protein 2 defines a subset of T-cell zone dendritic cells and is a ligand for class-I-restricted T-cell-associated molecule. (PMID: 15781451) Galibert L. … Yan W. (J. Biol. Chem. 2005) 3 4
  4. The tumor suppressor TSLC1/NECL-2 triggers NK-cell and CD8+ T-cell responses through the cell-surface receptor CRTAM. (PMID: 15811952) Boles K.S. … Colonna M. (Blood 2005) 3 4
  5. Characterization of CRTAM gene promoter: AP-1 transcription factor control its expression in human T CD8 lymphocytes. (PMID: 19695707) Valle-Rios R. … Ortiz-Navarrete V. (Mol. Immunol. 2009) 3 23

Products for CRTAM Gene

Sources for CRTAM Gene

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