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Aliases for CRTAC1 Gene

Aliases for CRTAC1 Gene

  • Cartilage Acidic Protein 1 2 3 5
  • ASPIC1 3 4
  • CEP-68 3 4
  • ASPIC 3 4
  • Chondrocyte Expressed Protein 68 KDa CEP-68 3
  • Acidic Secreted Protein In Cartilage 3
  • 68 KDa Chondrocyte-Expressed Protein 4
  • Cep68 4

External Ids for CRTAC1 Gene

Previous GeneCards Identifiers for CRTAC1 Gene

  • GC10M098518
  • GC10M098858
  • GC10M099755
  • GC10M099289
  • GC10M099614
  • GC10M093250

Summaries for CRTAC1 Gene

Entrez Gene Summary for CRTAC1 Gene

  • This gene encodes a glycosylated extracellular matrix protein that is found in the interterritorial matrix of articular deep zone cartilage. This protein is used as a marker to distinguish chondrocytes from osteoblasts and mesenchymal stem cells in culture. The presence of FG-GAP motifs and an RGD integrin-binding motif suggests that this protein may be involved in cell-cell or cell-matrix interactions. Copy number alterations in this gene have been observed in neurofibromatosis type 1-associated glomus tumors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

GeneCards Summary for CRTAC1 Gene

CRTAC1 (Cartilage Acidic Protein 1) is a Protein Coding gene. Diseases associated with CRTAC1 include Bone Fracture. GO annotations related to this gene include calcium ion binding.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRTAC1 Gene

Genomics for CRTAC1 Gene

Regulatory Elements for CRTAC1 Gene

Enhancers for CRTAC1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CRTAC1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CRTAC1 Gene

97,854,711 bp from pter
98,030,828 bp from pter
176,118 bases
Minus strand

Genomic View for CRTAC1 Gene

Genes around CRTAC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRTAC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRTAC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRTAC1 Gene

Proteins for CRTAC1 Gene

  • Protein details for CRTAC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cartilage acidic protein 1
    Protein Accession:
    Secondary Accessions:
    • B1ALN4
    • Q5T4F8
    • Q8N4H6
    • Q8TE52
    • Q9NQ78
    • Q9NQ80
    • Q9NW46

    Protein attributes for CRTAC1 Gene

    661 amino acids
    Molecular mass:
    71421 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH34245.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA91540.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB98268.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB98269.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI12584.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for CRTAC1 Gene


neXtProt entry for CRTAC1 Gene

Proteomics data for CRTAC1 Gene at MOPED

Post-translational modifications for CRTAC1 Gene

Other Protein References for CRTAC1 Gene

Antibody Products

No data available for DME Specific Peptides for CRTAC1 Gene

Domains & Families for CRTAC1 Gene

Protein Domains for CRTAC1 Gene

Suggested Antigen Peptide Sequences for CRTAC1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 EGF-like domain.
  • Contains 4 FG-GAP repeats.
  • Contains 1 EGF-like domain.
  • Contains 4 FG-GAP repeats.
genes like me logo Genes that share domains with CRTAC1: view

No data available for Gene Families for CRTAC1 Gene

Function for CRTAC1 Gene

Molecular function for CRTAC1 Gene

UniProtKB/Swiss-Prot Induction:
Up-regulated by BMP4 (at protein level). Up-regulated in mesenchymal stem cells undergoing chondrogenic differentiation and by BMP4.

Phenotypes for CRTAC1 Gene

MGI mutant phenotypes for CRTAC1:
inferred from 1 alleles
GenomeRNAi human phenotypes for CRTAC1:
genes like me logo Genes that share phenotypes with CRTAC1: view

Animal Models for CRTAC1 Gene

MGI Knock Outs for CRTAC1:

Animal Model Products

  • Taconic Biosciences Mouse Models for CRTAC1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CRTAC1 Gene

Localization for CRTAC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRTAC1 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

Jensen Localization Image for CRTAC1 Gene COMPARTMENTS Subcellular localization image for CRTAC1 gene
Compartment Confidence
extracellular 5
plasma membrane 2
lysosome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for CRTAC1 Gene

Pathways & Interactions for CRTAC1 Gene

SuperPathways for CRTAC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CRTAC1 Gene


No data available for Pathways by source and SIGNOR curated interactions for CRTAC1 Gene

Drugs & Compounds for CRTAC1 Gene

No Compound Related Data Available

Transcripts for CRTAC1 Gene

Unigene Clusters for CRTAC1 Gene

Cartilage acidic protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CRTAC1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20 ^ 21
SP1: - - - - - - -
SP2: - - -
SP3: - - -
SP5: - - - -
SP7: - - -

Relevant External Links for CRTAC1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CRTAC1 Gene

mRNA expression in normal human tissues for CRTAC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CRTAC1 Gene

This gene is overexpressed in Bladder (x5.5) and Artery - Tibial (x5.4).

Protein differential expression in normal tissues from HIPED for CRTAC1 Gene

This gene is overexpressed in Synovial fluid (40.0), Vitreous humor (10.4), and Cerebrospinal fluid (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CRTAC1 Gene

SOURCE GeneReport for Unigene cluster for CRTAC1 Gene Hs.500736

mRNA Expression by UniProt/SwissProt for CRTAC1 Gene

Tissue specificity: Expressed in the interterritorial matrix of articular deep zone cartilage (at protein level). Isoform 1 and isoform 2 are expressed in brain. Isoform 1 is detected in lung and chondrocytes. Detected in cartilage, bone, cultured chondrocytes and lung, and at low levels in heart. Not detected in osteoblasts.
genes like me logo Genes that share expression patterns with CRTAC1: view

Primer Products

No data available for Protein tissue co-expression partners for CRTAC1 Gene

Orthologs for CRTAC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CRTAC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CRTAC1 35
  • 92.04 (n)
  • 95.19 (a)
  • 94 (a)
(Canis familiaris)
Mammalia CRTAC1 35
  • 92.2 (n)
  • 96.23 (a)
  • 95 (a)
(Mus musculus)
Mammalia Crtac1 35
  • 88.68 (n)
  • 93.95 (a)
Crtac1 16
Crtac1 36
  • 89 (a)
(Pan troglodytes)
Mammalia CRTAC1 35
  • 98.39 (n)
  • 98.83 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Crtac1 35
  • 88.06 (n)
  • 93.8 (a)
(Monodelphis domestica)
Mammalia CRTAC1 36
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia CRTAC1 36
  • 77 (a)
(Gallus gallus)
Aves CRTAC1 35
  • 76.05 (n)
  • 80.91 (a)
  • 73 (a)
(Anolis carolinensis)
Reptilia CRTAC1 36
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia crtac1 35
  • 70.01 (n)
  • 79 (a)
(Danio rerio)
Actinopterygii crtac1b 35
  • 68.97 (n)
  • 74.05 (a)
Dr.6210 35
crtac1a 36
  • 67 (a)
crtac1b 36
  • 67 (a)
Species with no ortholog for CRTAC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CRTAC1 Gene

Gene Tree for CRTAC1 (if available)
Gene Tree for CRTAC1 (if available)

Paralogs for CRTAC1 Gene

No data available for Paralogs for CRTAC1 Gene

Variants for CRTAC1 Gene

Sequence variations from dbSNP and Humsavar for CRTAC1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs35853031 - 97,908,106(-) GCAGT(A/G)CCTCG reference, missense
rs2297935 - 97,880,363(+) GCACA(A/C/T)GAATG reference, missense
VAR_061152 -
rs1548052 -- 97,984,324(+) CCCCC(A/G)TCTGA intron-variant
rs3006 -- 97,879,670(+) TTCCT(G/T)TATTG intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CRTAC1 Gene

Variant ID Type Subtype PubMed ID
nsv819567 CNV Gain 19587683
nsv7510 CNV Insertion 18451855
nsv509364 CNV Insertion 20534489
nsv513013 CNV Insertion 21212237
nsv25263 CNV Loss 16902084
nsv831953 CNV Gain 17160897
esv270898 CNV Insertion 20981092
esv2660852 CNV Deletion 23128226

Variation tolerance for CRTAC1 Gene

Residual Variation Intolerance Score: 60.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.75; 66.51% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CRTAC1 Gene

Disorders for CRTAC1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CRTAC1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
bone fracture
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CRTAC1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CRTAC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CRTAC1 Gene

Publications for CRTAC1 Gene

  1. Chondrocyte expressed protein-68 (CEP-68), a novel human marker gene for cultured chondrocytes. (PMID: 11139377) Steck E. … Richter W. (Biochem. J. 2001) 2 3 4 67
  2. Genes up- or down-regulated by high calcium medium in parathyroid tissue explants from patients with primary hyperparathyroidism. (PMID: 19952464) Nakajima K. … Sato K. (Endocr. J. 2010) 3 23
  3. CRTAC1 homolog proteins are conserved from cyanobacteria to man and secreted by the teleost fish pituitary gland. (PMID: 20171266) Redruello B. … Power D.M. (Gene 2010) 3 23
  4. Chondrocyte secreted CRTAC1: a glycosylated extracellular matrix molecule of human articular cartilage. (PMID: 17074475) Steck E. … Richter W. (Matrix Biol. 2007) 3 23
  5. Detection of bone and cartilage-related proteins in plasma of patients with a bone fracture using liquid chromatography-mass spectrometry. (PMID: 17602227) Grgurevic L. … Vukicevic S. (Int Orthop 2007) 3 23

Products for CRTAC1 Gene

Sources for CRTAC1 Gene