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Aliases for CRTAC1 Gene

Aliases for CRTAC1 Gene

  • Cartilage Acidic Protein 1 2 3 5
  • ASPIC1 3 4
  • CEP-68 3 4
  • ASPIC 3 4
  • Chondrocyte Expressed Protein 68 KDa CEP-68 3
  • Acidic Secreted Protein In Cartilage 3
  • 68 KDa Chondrocyte-Expressed Protein 4
  • Cep68 4

External Ids for CRTAC1 Gene

Previous GeneCards Identifiers for CRTAC1 Gene

  • GC10M098518
  • GC10M098858
  • GC10M099755
  • GC10M099289
  • GC10M099614
  • GC10M093250

Summaries for CRTAC1 Gene

Entrez Gene Summary for CRTAC1 Gene

  • This gene encodes a glycosylated extracellular matrix protein that is found in the interterritorial matrix of articular deep zone cartilage. This protein is used as a marker to distinguish chondrocytes from osteoblasts and mesenchymal stem cells in culture. The presence of FG-GAP motifs and an RGD integrin-binding motif suggests that this protein may be involved in cell-cell or cell-matrix interactions. Copy number alterations in this gene have been observed in neurofibromatosis type 1-associated glomus tumors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

GeneCards Summary for CRTAC1 Gene

CRTAC1 (Cartilage Acidic Protein 1) is a Protein Coding gene. Diseases associated with CRTAC1 include Neurofibromatosis, Type 1 and Bone Fracture. GO annotations related to this gene include calcium ion binding.

Additional gene information for CRTAC1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRTAC1 Gene

Genomics for CRTAC1 Gene

Regulatory Elements for CRTAC1 Gene

Enhancers for CRTAC1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10H097786 1.5 Ensembl ENCODE dbSUPER 10.7 +242.5 242528 3 PKNOX1 FEZF1 ZNF2 TCF12 ZNF121 ZNF766 GLIS2 GATA2 NCOA1 REST MARVELD1 CRTAC1 ZFYVE27 SFRP5 PIR33458
GH10H097839 1.5 Ensembl ENCODE dbSUPER 10.3 +190.5 190489 1 ATF1 ARNT SIN3A TCF12 ELK1 FOS ATF7 SP3 MEF2D MBD2 CRTAC1 PYROXD2 GOLGA7B PIR33458 SFRP5
GH10H097914 1.1 Ensembl ENCODE 13.4 +115.9 115878 0 CTCF RB1 ETV1 SIN3A KLF17 EBF1 ZNF2 RAD21 CC2D1A GLIS2 CRTAC1 GC10M097904 GC10M097984
GH10H097770 1.4 Ensembl ENCODE dbSUPER 10.1 +258.9 258893 2 ZSCAN4 ZNF76 KLF17 ZEB1 TCF12 GLIS2 GATA2 EGR1 ZNF366 ZNF391 ZFYVE27 CRTAC1 MARVELD1 SFRP5
GH10H097792 1 ENCODE dbSUPER 10.3 +238.7 238670 0 HDGF CTCF RB1 KLF17 ZIC2 RAD21 GLIS2 PATZ1 SMC3 ZNF143 SFRP5 CRTAC1 PIR33458
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CRTAC1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CRTAC1 Gene

Chromosome:
10
Start:
97,854,711 bp from pter
End:
98,030,828 bp from pter
Size:
176,118 bases
Orientation:
Minus strand

Genomic View for CRTAC1 Gene

Genes around CRTAC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRTAC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRTAC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRTAC1 Gene

Proteins for CRTAC1 Gene

  • Protein details for CRTAC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQ79-CRAC1_HUMAN
    Recommended name:
    Cartilage acidic protein 1
    Protein Accession:
    Q9NQ79
    Secondary Accessions:
    • B1ALN4
    • Q5T4F8
    • Q8N4H6
    • Q8TE52
    • Q9NQ78
    • Q9NQ80
    • Q9NW46

    Protein attributes for CRTAC1 Gene

    Size:
    661 amino acids
    Molecular mass:
    71421 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH34245.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA91540.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB98268.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB98269.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI12584.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for CRTAC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CRTAC1 Gene

Post-translational modifications for CRTAC1 Gene

  • O-glycosylated.
  • Glycosylation at isoforms=608, isoforms=618, posLast=619619, posLast=621621, and isoforms=626
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CRTAC1 Gene

Domains & Families for CRTAC1 Gene

Gene Families for CRTAC1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for CRTAC1 Gene

Suggested Antigen Peptide Sequences for CRTAC1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CRTAC1: view

No data available for UniProtKB/Swiss-Prot for CRTAC1 Gene

Function for CRTAC1 Gene

Molecular function for CRTAC1 Gene

UniProtKB/Swiss-Prot Induction:
Up-regulated by BMP4 (at protein level). Up-regulated in mesenchymal stem cells undergoing chondrogenic differentiation and by BMP4.

Phenotypes From GWAS Catalog for CRTAC1 Gene

Gene Ontology (GO) - Molecular Function for CRTAC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CRTAC1: view

Phenotypes for CRTAC1 Gene

MGI mutant phenotypes for CRTAC1:
inferred from 1 alleles
GenomeRNAi human phenotypes for CRTAC1:
genes like me logo Genes that share phenotypes with CRTAC1: view

Animal Models for CRTAC1 Gene

MGI Knock Outs for CRTAC1:

Animal Model Products

  • Taconic Biosciences Mouse Models for CRTAC1

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CRTAC1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CRTAC1 Gene

Localization for CRTAC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRTAC1 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CRTAC1 gene
Compartment Confidence
extracellular 5
plasma membrane 2
lysosome 1

Gene Ontology (GO) - Cellular Components for CRTAC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0030426 growth cone IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with CRTAC1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CRTAC1 Gene

Pathways & Interactions for CRTAC1 Gene

SuperPathways for CRTAC1 Gene

No Data Available

Interacting Proteins for CRTAC1 Gene

Gene Ontology (GO) - Biological Process for CRTAC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007413 axonal fasciculation IEA --
GO:0021772 olfactory bulb development IEA --
GO:1900121 negative regulation of receptor binding IEA --
genes like me logo Genes that share ontologies with CRTAC1: view

No data available for Pathways by source and SIGNOR curated interactions for CRTAC1 Gene

Drugs & Compounds for CRTAC1 Gene

No Compound Related Data Available

Transcripts for CRTAC1 Gene

Unigene Clusters for CRTAC1 Gene

Cartilage acidic protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CRTAC1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for CRTAC1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20 ^ 21
SP1: - - - - - - -
SP2: - - -
SP3: - - -
SP4:
SP5: - - - -
SP6:
SP7: - - -

Relevant External Links for CRTAC1 Gene

GeneLoc Exon Structure for
CRTAC1
ECgene alternative splicing isoforms for
CRTAC1

Expression for CRTAC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CRTAC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CRTAC1 Gene

This gene is overexpressed in Bladder (x5.5) and Artery - Tibial (x5.4).

Protein differential expression in normal tissues from HIPED for CRTAC1 Gene

This gene is overexpressed in Synovial fluid (40.0), Vitreous humor (10.4), and Cerebrospinal fluid (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CRTAC1 Gene



NURSA nuclear receptor signaling pathways regulating expression of CRTAC1 Gene:

CRTAC1

SOURCE GeneReport for Unigene cluster for CRTAC1 Gene:

Hs.500736

mRNA Expression by UniProt/SwissProt for CRTAC1 Gene:

Q9NQ79-CRAC1_HUMAN
Tissue specificity: Expressed in the interterritorial matrix of articular deep zone cartilage (at protein level). Isoform 1 and isoform 2 are expressed in brain. Isoform 1 is detected in lung and chondrocytes. Detected in cartilage, bone, cultured chondrocytes and lung, and at low levels in heart. Not detected in osteoblasts.

Evidence on tissue expression from TISSUES for CRTAC1 Gene

  • Nervous system(4.7)
  • Eye(2.5)
genes like me logo Genes that share expression patterns with CRTAC1: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CRTAC1 Gene

Orthologs for CRTAC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CRTAC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CRTAC1 33 34
  • 98.39 (n)
dog
(Canis familiaris)
Mammalia CRTAC1 33 34
  • 92.2 (n)
cow
(Bos Taurus)
Mammalia CRTAC1 33 34
  • 92.04 (n)
oppossum
(Monodelphis domestica)
Mammalia CRTAC1 34
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Crtac1 33 16 34
  • 88.68 (n)
rat
(Rattus norvegicus)
Mammalia Crtac1 33
  • 88.06 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CRTAC1 34
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves CRTAC1 33 34
  • 76.05 (n)
lizard
(Anolis carolinensis)
Reptilia CRTAC1 34
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia crtac1 33
  • 70.01 (n)
zebrafish
(Danio rerio)
Actinopterygii crtac1b 33 34
  • 68.97 (n)
crtac1a 34
  • 67 (a)
OneToMany
Dr.6210 33
Species where no ortholog for CRTAC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CRTAC1 Gene

ENSEMBL:
Gene Tree for CRTAC1 (if available)
TreeFam:
Gene Tree for CRTAC1 (if available)

Paralogs for CRTAC1 Gene

No data available for Paralogs for CRTAC1 Gene

Variants for CRTAC1 Gene

Sequence variations from dbSNP and Humsavar for CRTAC1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000009290 -- 97,877,505(+) CCTAG(A/C)TCAGT intron-variant
rs1000011797 -- 97,955,392(+) TTACA(C/G)TGAGA intron-variant
rs1000075711 -- 97,904,225(+) TCCTA(C/T)AGCAG intron-variant
rs1000083887 -- 97,984,739(+) GGGCA(C/T)GTGAT intron-variant
rs1000083894 -- 97,877,071(+) GCAGG(A/G)GACTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CRTAC1 Gene

Variant ID Type Subtype PubMed ID
esv2660852 CNV deletion 23128226
esv3306622 CNV mobile element insertion 20981092
esv3444944 CNV insertion 20981092
esv3546732 CNV deletion 23714750
esv3624328 CNV loss 21293372
esv3624329 OTHER inversion 21293372
nsv1047572 CNV gain 25217958
nsv25263 CNV deletion 16902084
nsv474763 CNV novel sequence insertion 20440878
nsv509364 CNV insertion 20534489
nsv513013 CNV insertion 21212237
nsv7510 CNV insertion 18451855
nsv819567 CNV gain 19587683
nsv831953 CNV gain 17160897

Variation tolerance for CRTAC1 Gene

Residual Variation Intolerance Score: 60.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.75; 66.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CRTAC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CRTAC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRTAC1 Gene

Disorders for CRTAC1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CRTAC1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
neurofibromatosis, type 1
  • neurofibromatosis
bone fracture
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CRTAC1

Genetic Association Database (GAD)
CRTAC1
Human Genome Epidemiology (HuGE) Navigator
CRTAC1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CRTAC1
genes like me logo Genes that share disorders with CRTAC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CRTAC1 Gene

Publications for CRTAC1 Gene

  1. Chondrocyte secreted CRTAC1: a glycosylated extracellular matrix molecule of human articular cartilage. (PMID: 17074475) Steck E … Richter W (Matrix biology : journal of the International Society for Matrix Biology 2007) 3 4 22 60
  2. Chondrocyte expressed protein-68 (CEP-68), a novel human marker gene for cultured chondrocytes. (PMID: 11139377) Steck E … Richter W (The Biochemical journal 2001) 2 3 4 60
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  4. A genome-wide association study of the metabolic syndrome in Indian Asian men. (PMID: 20694148) Zabaneh D … Balding DJ (PloS one 2010) 3 45 60
  5. CRTAC1 homolog proteins are conserved from cyanobacteria to man and secreted by the teleost fish pituitary gland. (PMID: 20171266) Redruello B … Power DM (Gene 2010) 3 22 60

Products for CRTAC1 Gene

Sources for CRTAC1 Gene

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