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Aliases for CRTAC1 Gene

Aliases for CRTAC1 Gene

  • Cartilage Acidic Protein 1 2 3
  • ASPIC1 3 4
  • CEP-68 3 4
  • ASPIC 3 4
  • Chondrocyte Expressed Protein 68 KDa CEP-68 3
  • Acidic Secreted Protein In Cartilage 3
  • 68 KDa Chondrocyte-Expressed Protein 4
  • CEP68 4

External Ids for CRTAC1 Gene

Previous GeneCards Identifiers for CRTAC1 Gene

  • GC10M098518
  • GC10M098858
  • GC10M099755
  • GC10M099289
  • GC10M099614
  • GC10M093250

Summaries for CRTAC1 Gene

Entrez Gene Summary for CRTAC1 Gene

  • This gene encodes a glycosylated extracellular matrix protein that is found in the interterritorial matrix of articular deep zone cartilage. This protein is used as a marker to distinguish chondrocytes from osteoblasts and mesenchymal stem cells in culture. The presence of FG-GAP motifs and an RGD integrin-binding motif suggests that this protein may be involved in cell-cell or cell-matrix interactions. Copy number alterations in this gene have been observed in neurofibromatosis type 1-associated glomus tumors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

GeneCards Summary for CRTAC1 Gene

CRTAC1 (Cartilage Acidic Protein 1) is a Protein Coding gene. Diseases associated with CRTAC1 include botulism and neurofibromatosis. GO annotations related to this gene include calcium ion binding.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRTAC1 Gene

Genomics for CRTAC1 Gene

Regulatory Elements for CRTAC1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CRTAC1 Gene

Start:
97,865,000 bp from pter
End:
98,030,828 bp from pter
Size:
165,829 bases
Orientation:
Minus strand

Genomic View for CRTAC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CRTAC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRTAC1 Gene

Proteins for CRTAC1 Gene

  • Protein details for CRTAC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQ79-CRAC1_HUMAN
    Recommended name:
    Cartilage acidic protein 1
    Protein Accession:
    Q9NQ79
    Secondary Accessions:
    • B1ALN4
    • Q5T4F8
    • Q8N4H6
    • Q8TE52
    • Q9NQ78
    • Q9NQ80
    • Q9NW46

    Protein attributes for CRTAC1 Gene

    Size:
    661 amino acids
    Molecular mass:
    71421 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH34245.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA91540.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB98268.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB98269.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI12584.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for CRTAC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CRTAC1 Gene

Proteomics data for CRTAC1 Gene at MOPED

Post-translational modifications for CRTAC1 Gene

Other Protein References for CRTAC1 Gene

Antibody Products

No data available for DME Specific Peptides for CRTAC1 Gene

Domains for CRTAC1 Gene

Protein Domains for CRTAC1 Gene

Suggested Antigen Peptide Sequences for CRTAC1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NQ79

UniProtKB/Swiss-Prot:

CRAC1_HUMAN :
  • Q9NQ79
Domain:
  • Contains 1 EGF-like domain.
Similarity:
  • Contains 4 FG-GAP repeats.
genes like me logo Genes that share domains with CRTAC1: view

No data available for Gene Families for CRTAC1 Gene

Function for CRTAC1 Gene

Molecular function for CRTAC1 Gene

UniProtKB/Swiss-Prot Induction: Up-regulated by BMP4 (at protein level). Up-regulated in mesenchymal stem cells undergoing chondrogenic differentiation and by BMP4.

Gene Ontology (GO) - Molecular Function for CRTAC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CRTAC1: view

Phenotypes for CRTAC1 Gene

genes like me logo Genes that share phenotypes with CRTAC1: view

Animal Models for CRTAC1 Gene

MGI Knock Outs for CRTAC1:

Animal Model Products

CRISPR Products

miRNA for CRTAC1 Gene

miRTarBase miRNAs that target CRTAC1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CRTAC1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CRTAC1 Gene

Localization for CRTAC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRTAC1 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CRTAC1 Gene COMPARTMENTS Subcellular localization image for CRTAC1 gene
Compartment Confidence
extracellular 5
plasma membrane 2
lysosome 1

Gene Ontology (GO) - Cellular Components for CRTAC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0030426 growth cone IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with CRTAC1: view

Pathways for CRTAC1 Gene

SuperPathways for CRTAC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CRTAC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007413 axonal fasciculation IEA --
GO:0021772 olfactory bulb development IEA --
GO:1900121 negative regulation of receptor binding IEA --
genes like me logo Genes that share ontologies with CRTAC1: view

No data available for Pathways by source for CRTAC1 Gene

Transcripts for CRTAC1 Gene

Unigene Clusters for CRTAC1 Gene

Cartilage acidic protein 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CRTAC1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CRTAC1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CRTAC1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20 ^ 21
SP1: - - - - - - -
SP2: - - -
SP3: - - -
SP4:
SP5: - - - -
SP6:
SP7: - - -

Relevant External Links for CRTAC1 Gene

GeneLoc Exon Structure for
CRTAC1
ECgene alternative splicing isoforms for
CRTAC1

Expression for CRTAC1 Gene

mRNA expression in normal human tissues for CRTAC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CRTAC1 Gene

This gene is overexpressed in Bladder (5.5) and Artery - Tibial (5.4).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CRTAC1 Gene

SOURCE GeneReport for Unigene cluster for CRTAC1 Gene Hs.500736

mRNA Expression by UniProt/SwissProt for CRTAC1 Gene

Q9NQ79-CRAC1_HUMAN
Tissue specificity: Expressed in the interterritorial matrix of articular deep zone cartilage (at protein level). Isoform 1 and isoform 2 are expressed in brain. Isoform 1 is detected in lung and chondrocytes. Detected in cartilage, bone, cultured chondrocytes and lung, and at low levels in heart. Not detected in osteoblasts.
genes like me logo Genes that share expressions with CRTAC1: view

In Situ Assay Products

Orthologs for CRTAC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CRTAC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CRTAC1 35
  • 98.39 (n)
  • 98.83 (a)
CRTAC1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CRTAC1 35
  • 92.04 (n)
  • 95.19 (a)
CRTAC1 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CRTAC1 35
  • 92.2 (n)
  • 96.23 (a)
CRTAC1 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Crtac1 35
  • 88.68 (n)
  • 93.95 (a)
Crtac1 16
Crtac1 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CRTAC1 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CRTAC1 36
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Crtac1 35
  • 88.06 (n)
  • 93.8 (a)
chicken
(Gallus gallus)
Aves CRTAC1 35
  • 76.05 (n)
  • 80.91 (a)
CRTAC1 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CRTAC1 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia crtac1 35
  • 70.01 (n)
  • 79 (a)
zebrafish
(Danio rerio)
Actinopterygii crtac1a 36
  • 67 (a)
OneToMany
crtac1b 35
  • 68.97 (n)
  • 74.05 (a)
crtac1b 36
  • 67 (a)
OneToMany
Dr.6210 35
Species with no ortholog for CRTAC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CRTAC1 Gene

ENSEMBL:
Gene Tree for CRTAC1 (if available)
TreeFam:
Gene Tree for CRTAC1 (if available)

Paralogs for CRTAC1 Gene

No data available for Paralogs for CRTAC1 Gene

Variants for CRTAC1 Gene

Sequence variations from dbSNP and Humsavar for CRTAC1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs3006 -- 97,879,670(+) TTCCT(G/T)TATTG utr-variant-3-prime, intron-variant
rs472576 -- 97,935,213(+) TTGTG(C/G)CTCAG intron-variant
rs472818 -- 97,935,300(-) TCTAA(A/G)CATTT intron-variant
rs472885 -- 98,000,137(+) TCTTC(C/G)GGGTT intron-variant
rs473833 -- 98,000,251(+) AGGAG(A/T)GAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CRTAC1 Gene

Variant ID Type Subtype PubMed ID
nsv819567 CNV Gain 19587683
nsv7510 CNV Insertion 18451855
nsv509364 CNV Insertion 20534489
nsv513013 CNV Insertion 21212237
nsv25263 CNV Loss 16902084
nsv831953 CNV Gain 17160897
esv270898 CNV Insertion 20981092
esv2660852 CNV Deletion 23128226

Relevant External Links for CRTAC1 Gene

HapMap Linkage Disequilibrium report
CRTAC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRTAC1 Gene

Disorders for CRTAC1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for CRTAC1 Gene including...

Search for CRTAC1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for CRTAC1 Gene

Relevant External Links for CRTAC1

Genetic Association Database (GAD)
CRTAC1
Human Genome Epidemiology (HuGE) Navigator
CRTAC1
genes like me logo Genes that share disorders with CRTAC1: view

No data available for UniProtKB/Swiss-Prot for CRTAC1 Gene

Publications for CRTAC1 Gene

  1. Chondrocyte secreted CRTAC1: a glycosylated extracellular matrix molecule of human articular cartilage. (PMID: 17074475) Steck E. … Richter W. (Matrix Biol. 2007) 3 4 23
  2. Chondrocyte expressed protein-68 (CEP-68), a novel human marker gene for cultured chondrocytes. (PMID: 11139377) Steck E. … Richter W. (Biochem. J. 2001) 2 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. A genome-wide association study of the metabolic syndrome in Indian Asian men. (PMID: 20694148) Zabaneh D. … Balding D.J. (PLoS ONE 2010) 3 48
  5. Detection of bone and cartilage-related proteins in plasma of patients with a bone fracture using liquid chromatography-mass spectrometry. (PMID: 17602227) Grgurevic L. … Vukicevic S. (Int Orthop 2007) 3 23

Products for CRTAC1 Gene

Sources for CRTAC1 Gene

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