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Aliases for CRP Gene

Aliases for CRP Gene

  • C-Reactive Protein, Pentraxin-Related 2 3
  • Pentraxin 1 2 3
  • PTX1 3 4
  • C-Reactive Protein 3

External Ids for CRP Gene

Previous GeneCards Identifiers for CRP Gene

  • GC01M157474
  • GC01M155414
  • GC01M156459
  • GC01M156899
  • GC01M156495
  • GC01M157948
  • GC01M131038

Summaries for CRP Gene

Entrez Gene Summary for CRP Gene

  • The protein encoded by this gene belongs to the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. [provided by RefSeq, Sep 2009]

GeneCards Summary for CRP Gene

CRP (C-Reactive Protein, Pentraxin-Related) is a Protein Coding gene. Diseases associated with CRP include pneumonia and appendicitis. Among its related pathways are Activation of cAMP-Dependent PKA and Activation of cAMP-Dependent PKA. GO annotations related to this gene include protein homodimerization activity and low-density lipoprotein particle binding. An important paralog of this gene is PTX3.

UniProtKB/Swiss-Prot for CRP Gene

  • Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells

Gene Wiki entry for CRP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRP Gene

Genomics for CRP Gene

Regulatory Elements for CRP Gene

Genomic Location for CRP Gene

Start:
159,712,289 bp from pter
End:
159,714,589 bp from pter
Size:
2,301 bases
Orientation:
Minus strand

Genomic View for CRP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CRP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRP Gene

Proteins for CRP Gene

  • Protein details for CRP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P02741-CRP_HUMAN
    Recommended name:
    C-reactive protein
    Protein Accession:
    P02741
    Secondary Accessions:
    • A8K078
    • D3DVD9
    • D3DVE0
    • Q08AK3
    • Q8WW75

    Protein attributes for CRP Gene

    Size:
    224 amino acids
    Molecular mass:
    25039 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 2 calcium ions per subunit.;
    Quaternary structure:
    • Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits. Interacts with FCN1; may regulate monocyte activation by FCN1.
    Miscellaneous:
    • This protein owes its name to its ability precipitate pneumococcal C-polysaccharide in the presence of calcium

    Three dimensional structures from OCA and Proteopedia for CRP Gene

    Alternative splice isoforms for CRP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CRP Gene

Proteomics data for CRP Gene at MOPED

Post-translational modifications for CRP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CRP Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CRP (C-Reactive Protein/CRP)
  • Cell Signaling Technology (CST) Antibodies for CRP (CRP)

Protein Products

No data available for DME Specific Peptides for CRP Gene

Domains for CRP Gene

Protein Domains for CRP Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CRP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P02741

UniProtKB/Swiss-Prot:

CRP_HUMAN :
  • P02741
Domain:
  • Contains 1 pentaxin domain.
Family:
  • Belongs to the pentaxin family.
genes like me logo Genes that share domains with CRP: view

No data available for Gene Families for CRP Gene

Function for CRP Gene

Molecular function for CRP Gene

GENATLAS Biochemistry: C-reactive protein,acute phase reactant,pentaxin (pentraxin) family,bacterial catabolite activator protein
UniProtKB/Swiss-Prot Function: Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells
UniProtKB/Swiss-Prot Induction: The concentration of CRP in plasma increases greatly during acute phase response to tissue injury, infection or other inflammatory stimuli. It is induced by IL1/interleukin-1 and IL6/interleukin-6

Gene Ontology (GO) - Molecular Function for CRP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001849 complement component C1q binding IDA 23544079
GO:0005509 calcium ion binding IDA 23544079
GO:0005515 protein binding IPI 17785206
GO:0015485 cholesterol binding IEA --
GO:0030169 low-density lipoprotein particle binding IDA 18322245
genes like me logo Genes that share ontologies with CRP: view
genes like me logo Genes that share phenotypes with CRP: view

Animal Models for CRP Gene

MGI Knock Outs for CRP:

Animal Model Products

  • Taconic Biosciences Mouse Models for CRP TF1323 Crp

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CRP

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for CRP Gene

Localization for CRP Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRP Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CRP Gene COMPARTMENTS Subcellular localization image for CRP gene
Compartment Confidence
extracellular 5
cytoskeleton 2
cytosol 2
mitochondrion 2
nucleus 2
plasma membrane 2
endoplasmic reticulum 1
golgi apparatus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CRP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 14718574
GO:0005615 extracellular space IDA 23544079
GO:0030175 filopodium IEA --
GO:0030426 growth cone IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with CRP: view

Pathways for CRP Gene

genes like me logo Genes that share pathways with CRP: view

PCR Array Products

Gene Ontology (GO) - Biological Process for CRP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0006953 acute-phase response TAS 2477488
GO:0006954 inflammatory response TAS 10408362
GO:0006958 complement activation, classical pathway IEA --
GO:0007568 aging IEA --
genes like me logo Genes that share ontologies with CRP: view

Compounds for CRP Gene

(3) HMDB Compounds for CRP Gene

Compound Synonyms Cas Number PubMed IDs
Atorvastatin
  • Atorvastatin acid
134523-00-5
Calcium
  • Ca
7440-70-2
Phosphorylcholine
  • Choline phosphate
3616-04-4

(1) Drugbank Compounds for CRP Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Phosphocholine
107-73-3 target

(134) Novoseek inferred chemical compound relationships for CRP Gene

Compound -log(P) Hits PubMed IDs
fibrinogen 87.4 437
cholesterol 80.1 266
homocysteine 75 250
neopterin 71.9 194
creatinine 69.4 174

(2) PharmGKB related drug/compound annotations for CRP Gene

Drug/compound Annotation
fenofibrate CA
rituximab
genes like me logo Genes that share compounds with CRP: view

Transcripts for CRP Gene

Unigene Clusters for CRP Gene

C-reactive protein, pentraxin-related:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CRP

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CRP

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CRP Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f
SP1: - -
SP2: - - -
SP3: - - -
SP4: - - - - -
SP5: - -
SP6:
SP7: - - - -
SP8: -

Relevant External Links for CRP Gene

GeneLoc Exon Structure for
CRP
ECgene alternative splicing isoforms for
CRP

Expression for CRP Gene

mRNA expression in normal human tissues for CRP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CRP Gene

This gene is overexpressed in Liver (52.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CRP Gene

SOURCE GeneReport for Unigene cluster for CRP Gene Hs.76452

mRNA Expression by UniProt/SwissProt for CRP Gene

P02741-CRP_HUMAN
Tissue specificity: Found in plasma
genes like me logo Genes that share expressions with CRP: view

In Situ Assay Products

Orthologs for CRP Gene

This gene was present in the common ancestor of chordates.

Orthologs for CRP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CRP 35
  • 99.55 (n)
  • 99.11 (a)
CRP 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CRP 35
  • 79.07 (n)
  • 70.4 (a)
CRP 36
  • 70 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CRP 35
  • 69.23 (n)
  • 61.09 (a)
CRP 36
  • 54 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Crp 35
  • 76.08 (n)
  • 70.4 (a)
Crp 16
Crp 36
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CRP 36
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 49 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Crp 35
  • 74.17 (n)
  • 67.12 (a)
chicken
(Gallus gallus)
Aves CRP 35
  • 55.71 (n)
  • 48.15 (a)
CRP 36
  • 46 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 19 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.16219 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486739 35
  • 52.82 (n)
  • 45.21 (a)
zebrafish
(Danio rerio)
Actinopterygii CRP 36
  • 21 (a)
OneToMany
Species with no ortholog for CRP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CRP Gene

ENSEMBL:
Gene Tree for CRP (if available)
TreeFam:
Gene Tree for CRP (if available)

Paralogs for CRP Gene

Paralogs for CRP Gene

Selected SIMAP similar genes for CRP Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for CRP Gene

genes like me logo Genes that share paralogs with CRP: view

Variants for CRP Gene

Sequence variations from dbSNP and Humsavar for CRP Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1205 -- 159,712,443(+) CCTCA(C/T)AGTCT utr-variant-3-prime
rs1050031 -- 159,713,059(-) TCAGT(A/C)TCAGA utr-variant-3-prime
rs1130864 -- 159,713,301(-) GGAAA(C/T)GGTCC utr-variant-3-prime
rs1417938 -- 159,714,396(+) TCAAA(A/T)CTCTC intron-variant
rs1800947 -- 159,713,648(-) GTGCT(C/G)TCACC synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for CRP Gene

Variant ID Type Subtype PubMed ID
nsv825076 CNV Loss 20364138

Relevant External Links for CRP Gene

HapMap Linkage Disequilibrium report
CRP
Human Gene Mutation Database (HGMD)
CRP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRP Gene

Disorders for CRP Gene

MalaCards: The human disease database

MalaCards: The human disease database. (102) Diseases for CRP Gene including...

Search for CRP Gene in MalaCards »

(92) Novoseek inferred disease relationships for CRP Gene

Disease -log(P) Hits PubMed IDs
inflammation 92.2 234
response acute phase 90 125
cardiovascular diseases 85.5 188
rheumatoid arthritis 84.5 108
atherosclerosis 84.4 195

Relevant External Links for CRP

Genetic Association Database (GAD)
CRP
Human Genome Epidemiology (HuGE) Navigator
CRP
genes like me logo Genes that share disorders with CRP: view

No data available for UniProtKB/Swiss-Prot for CRP Gene

Publications for CRP Gene

  1. The physiological structure of human C-reactive protein and its complex with phosphocholine. (PMID: 10368284) Thompson D. … Wood S.P. (Structure 1999) 3 4 23
  2. Association between baseline levels of C-reactive protein (CRP) and a dinucleotide repeat polymorphism in the intron of the CRP gene. (PMID: 11857055) Szalai A.J. … Kimberly R.P. (Genes Immun. 2002) 3 23 48
  3. The influence of tumor necrosis factor -308 and C-reactive protein G1059C gene variants on serum concentration of C-reactive protein: evidence for an age-dependent association. (PMID: 15469865) AraA_jo F. … Mansur A.J. (Clin. Chim. Acta 2004) 3 23 48
  4. C-reactive protein gene polymorphisms and the incidence of post-angioplasty restenosis. (PMID: 15380464) Zee R.Y. … Lindpaintner K. (Atherosclerosis 2004) 3 23 48
  5. Relation of polymorphism within the C-reactive protein gene and plasma CRP levels. (PMID: 15585211) Suk H.J. … Zee R.Y. (Atherosclerosis 2005) 3 23 48

Products for CRP Gene

Sources for CRP Gene

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