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CRP Gene

protein-coding   GIFtS: 65
GCID: GC01M159682

C-Reactive Protein, Pentraxin-Related

  See CRP-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
C-Reactive Protein, Pentraxin-Related1 2
Pentraxin 11 2
PTX12 3
C-Reactive Protein2

External Ids:    HGNC: 23671   Entrez Gene: 14012   Ensembl: ENSG000001326937   OMIM: 1232605   UniProtKB: P027413   

Export aliases for CRP gene to outside databases

Previous GC identifers: GC01M157474 GC01M155414 GC01M156459 GC01M156899 GC01M156495 GC01M157948 GC01M131038


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CRP Gene:
The protein encoded by this gene belongs to the pentaxin family. It is involved in several host defense related
functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their
elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of
this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other
inflammatory stimuli. (provided by RefSeq, Sep 2009)

GeneCards Summary for CRP Gene:
CRP (C-reactive protein, pentraxin-related) is a protein-coding gene. Diseases associated with CRP include pneumonia, and appendicitis. GO annotations related to this gene include low-density lipoprotein particle binding and protein homodimerization activity. An important paralog of this gene is NPTX2.

UniProtKB/Swiss-Prot: CRP_HUMAN, P02741
Function: Displays several functions associated with host defense: it promotes agglutination, bacterial capsular
swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can
interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells

Gene Wiki entry for CRP (C-reactive protein) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the CRP gene promoter:
         Max1   TBP   FOXO3   CUTL1   Nkx2-5   FOXO3b   AREB6   FOXO3a   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCRP promoter sequence
   Search Chromatin IP Primers for CRP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CRP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23.2   Ensembl cytogenetic band:  1q23.2   HGNC cytogenetic band: 1q23.2

CRP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRP gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M159682:  view genomic region     (about GC identifiers)

Start:
159,682,079 bp from pter      End:
159,684,379 bp from pter
Size:
2,301 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CRP_HUMAN, P02741 (See protein sequence)
Recommended Name: C-reactive protein precursor  
Size: 224 amino acids; 25039 Da
Cofactor: Binds 2 calcium ions per subunit
Subunit: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits
Mass spectrometry: Mass=23028; Method=MALDI; Range=19-224; Source=Ref.15;
Mass spectrometry: Mass=22930; Method=MALDI; Range=19-223; Source=Ref.15;
Miscellaneous: This protein owes its name to its ability precipitate pneumococcal C-polysaccharide in the presence
of calcium
Selected PDB 3D structures from and Proteopedia for CRP (see all 7):
1B09 (3D)        1CRV (3D)        1GNH (3D)        1LJ7 (3D)        3L2Y (3D)        3PVN (3D)    
Secondary accessions: A8K078 D3DVD9 D3DVE0 Q08AK3 Q8WW75
Alternative splicing: 2 isoforms:  P02741-1   P02741-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CRP: NX_P02741

Explore proteomics data for CRP at MOPED


See CRP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_000558.2  
ENSEMBL proteins: 
 ENSP00000255030   ENSP00000357093   ENSP00000357092   ENSP00000357091   ENSP00000340882  
 ENSP00000402788  
Reactome Protein details: P02741

CRP Human Recombinant Protein Products:

EMD Millipore Purified and/or Recombinant CRP Protein
R&D Systems Recombinant & Natural Proteins for CRP (C-Reactive Protein/CRP)
Browse recombinant and purified proteins available from Enzo Life Sciences
OriGene Purified Protein for CRP
OriGene Protein Over-expression Lysate for CRP
OriGene MassSpec for CRP
OriGene Custom Protein Services for CRP
GenScript Custom Purified and Recombinant Proteins Services for CRP
Novus Biologicals CRP Proteins
Novus Biologicals CRP Lysates
Sino Biological Recombinant Protein for CRP
Sino Biological Cell Lysate for CRP
ProSpec Recombinant Protein for CRP
Cloud-Clone Corp. Proteins for CRP

 
Search eBioscience for Proteins for CRP 

 
antibodies-online proteins for CRP (93 products) 

 
antibodies-online peptides for CRP

CRP Antibody Products:

EMD Millipore Mono- and Polyclonal Antibodies for the study of CRP
R&D Systems Antibodies for CRP (C-Reactive Protein/CRP)
OriGene Antibodies for CRP
OriGene Custom Antibody Services for CRP
Novus Biologicals CRP Antibodies
Abcam antibodies for CRP
Cloud-Clone Corp. Antibodies for CRP
ThermoFisher Antibody for CRP
LSBio Antibodies in human, mouse, rat for CRP
antibodies-online antibodies for CRP (452 products) 

CRP Assay Products:

EMD Millipore Kits and Assays for the Analysis of CRP
OriGene Custom Assay Services for CRP
R&D Systems ELISAs for CRP (C-Reactive Protein/CRP)         (see all)
GenScript Custom Assay Services for CRP
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for CRP
Cloud-Clone Corp. CLIAs for CRP
eBioscience ELISAs for CRP: (see all 3
                    Human CRP Instant ELISA 128 tests
antibodies-online kits for CRP (92 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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3 InterPro protein domains:
 IPR013320 ConA-like_subgrp
 IPR001759 Pentaxin
 IPR008985 ConA-like_lec_gl_sf

Graphical View of Domain Structure for InterPro Entry P02741

ProtoNet protein and cluster: P02741

1 Blocks protein domain: IPB001759 Pentaxin

UniProtKB/Swiss-Prot: CRP_HUMAN, P02741
Similarity: Belongs to the pentaxin family
Similarity: Contains 1 pentaxin domain


Find genes that share domains with CRP           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: CRP_HUMAN, P02741
Function: Displays several functions associated with host defense: it promotes agglutination, bacterial capsular
swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can
interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells
Induction: The concentration of CRP in plasma increases greatly during acute phase response to tissue injury,
infection or other inflammatory stimuli. It is induced by IL1/interleukin-1 and IL6//interleukin-6

     Genatlas biochemistry entry for CRP:
C-reactive protein,acute phase reactant,pentaxin (pentraxin) family,bacterial catabolite activator protein

     Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding IPI17785206
GO:0015485cholesterol binding IEA--
GO:0030169low-density lipoprotein particle binding IDA18322245
GO:0033265choline binding TAS2477488
GO:0042803protein homodimerization activity IEA--
     
Find genes that share ontologies with CRP           About GenesLikeMe


Phenotypes:
     1 GenomeRNAi human phenotype for CRP:
 Synthetic lethal with c-Myc af 

     3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Crp):
 cardiovascular system  homeostasis/metabolism  immune system 

Find genes that share phenotypes with CRP           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Crptm1Hjf for CRP

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CRP
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CRP

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CRP
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CRP

miRNA
Products:
    
Block miRNA regulation of human, mouse, rat CRP using miScript Target Protectors
2 qRT-PCR Assays for microRNAs that regulate CRP:
hsa-miR-637 hsa-miR-218-1*
SwitchGear 3'UTR luciferase reporter plasmidCRP 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for CRP
Predesigned siRNA for gene silencing in human, mouse, rat CRP

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for CRP

Clone
Products:
     
OriGene clones in human, mouse for CRP (see all 7)
OriGene ORF clones in mouse, rat for CRP
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript Custom all cDNA clones Services for CRP
Sino Biological Human cDNA Clone for CRP
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRP
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRP

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for CRP
Browse ESI BIO Cell Lines and PureStem Progenitors for CRP 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRP


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
CRP_HUMAN, P02741: Secreted
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular5
cytoskeleton2
cytosol2
mitochondrion2
nucleus2
plasma membrane2
endoplasmic reticulum1
golgi apparatus1
peroxisome1

Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region NAS14718574
GO:0005615extracellular space IEA--
GO:0005739mitochondrion ----
GO:0005886plasma membrane ----
GO:0030175filopodium IEA--

Find genes that share ontologies with CRP           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for CRP About   (see all 8)  
See pathways by source

SuperPathContained pathways About
1Creation of C4 and C2 activators
Creation of C4 and C2 activators0.85
Classical antibody-mediated complement activation0.82
Initial triggering of complement0.85
Complement cascade0.68
2Activation of cAMP-Dependent PKA
Activation of cAMP-Dependent PKA0.77
Activation of PKA through GPCR0.71
cAMP Pathway0.77
PKA Signaling0.56
3Complement Pathway
Immune response Classic complement pathway0.56
4Jak/Stat Pathway
Development Thrombopoetin signaling via JAK STAT pathway0.32
5Selenium Pathway
Selenium Pathway


Find genes that share SuperPaths with CRP           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CRP
    Activation of PKA through GPCR
PKA Signaling
cAMP Pathway
Activation of cAMP-Dependent PKA

3 GeneGo (Thomson Reuters) Pathways for CRP
    Development Leptin signaling via JAK/STAT and MAPK cascades
Immune response Classical complement pathway
Development Thrombopoetin signaling via JAK-STAT pathway

2 BioSystems Pathways for CRP
    Selenium Pathway
IL6-mediated signaling events


1 Reactome Pathway for CRP
    Classical antibody-mediated complement activation


    Pathway & Disease-focused RT2 Profiler PCR Arrays including CRP (see all 8): 
          Inflammatory Response & Autoimmunity in human mouse rat
          JAK / STAT Signaling Pathway in human mouse rat
          Inflammatory Response & Autoimmunity 384HT in human mouse rat
          Stress & Toxicity PathwayFinder in human mouse rat
          Antibacterial Response in human mouse rat

Interactions:

    GeneGlobe Interaction Network for CRP

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for CRP (P027411, 2, 3 ENSP000002550304) via UniProtKB, MINT, STRING, and/or I2D (see all 38)
InteractantInteraction Details
GeneCardExternal ID(s)
FCGR2CP319951, 3EBI-1395983,EBI-1396036 I2D: score=1 
HIST1H2AGP0C0S83, ENSP000003521194I2D: score=1 STRING: ENSP00000352119
HIST1H2AIP0C0S83I2D: score=1 
HIST1H2AKP0C0S83I2D: score=1 
HIST1H2ALP0C0S83I2D: score=1 
About this table

Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001666response to hypoxia IEA--
GO:0006953acute-phase response TAS2477488
GO:0006954inflammatory response TAS10408362
GO:0006958complement activation, classical pathway IEA--
GO:0007568aging IEA--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for CRP

3 HMDB Compounds for CRP    About this table
CompoundSynonyms CAS #PubMed Ids
AtorvastatinAtorvastatin acid (see all 4)134523-00-5--
CalciumCa (see all 2)7440-70-2--
PhosphorylcholineCholine phosphate (see all 5)3616-04-4--

1 DrugBank Compound for CRP    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
Phosphocholine-- 107-73-3target--17139284 17016423

Selected Novoseek inferred chemical compound relationships for CRP gene (see all 134)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
fibrinogen 87.4 1760 12738395 (10), 16703188 (8), 11427220 (7), 16698114 (7) (see all 99)
cholesterol 80.1 1366 15635109 (8), 15766555 (7), 17996517 (6), 12102655 (5) (see all 99)
homocysteine 75 478 17852421 (7), 19362308 (7), 15051846 (6), 18311078 (5) (see all 99)
neopterin 71.9 258 18541395 (7), 1764778 (5), 15848499 (5), 19282816 (5) (see all 96)
creatinine 69.4 495 14655192 (5), 12748357 (5), 15811980 (5), 18609082 (4) (see all 99)
infliximab 69 89 16344720 (5), 15641046 (5), 15485995 (4), 15958758 (4) (see all 37)
atorvastatin 68.4 151 12595863 (5), 15843280 (5), 12009719 (4), 18991814 (4) (see all 72)
glucose 66 838 14706052 (7), 18691271 (7), 19130414 (5), 15955391 (5) (see all 99)
aopp 65.1 65 18786315 (7), 17058827 (4), 15354943 (3), 18976759 (3) (see all 22)
lipid 64.8 562 19621193 (6), 17356986 (5), 12542120 (5), 16775668 (5) (see all 99)

2 PharmGKB related drug/compound annotations for CRP gene    About this table
Drug/compound PharmGKB Annotation
fenofibrateCA  
rituximab



Find genes that share compounds with CRP           About GenesLikeMe



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for CRP gene: 
NM_000567.2  

Unigene Cluster for CRP:

C-reactive protein, pentraxin-related
Hs.76452  [show with all ESTs]
Unigene Representative Sequence: NM_000567
8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000255030(uc001ftw.3 uc001ftx.1) ENST00000473196 ENST00000368112
ENST00000368111 ENST00000489317 ENST00000368110 ENST00000343919 ENST00000437342(uc001fty.1)

miRNA
Products:
     
Block miRNA regulation of human, mouse, rat CRP using miScript Target Protectors
2 qRT-PCR Assays for microRNAs that regulate CRP:
hsa-miR-637 hsa-miR-218-1*
SwitchGear 3'UTR luciferase reporter plasmidCRP 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for CRP
Predesigned siRNA for gene silencing in human, mouse, rat CRP
Clone
Products:
     
OriGene clones in human, mouse for CRP (see all 7)
OriGene ORF clones in mouse, rat for CRP
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript Custom all cDNA clones Services for CRP
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRP
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRP
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for CRP
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CRP
  QuantiTect SYBR Green Assays in human, mouse, rat CRP
  QuantiFast Probe-based Assays in human, mouse, rat CRP

Additional mRNA sequence: 

AK289443.1 AK313624.1 BC125135.1 X56214.1 X56692.1 

16 DOTS entries:

DT.448901  DT.100826852  DT.102829615  DT.92446914  DT.100826853  DT.100826854  DT.92446905  DT.92446889 
DT.92446903  DT.92446904  DT.92446908  DT.92446913  DT.95111437  DT.95111452  DT.95111466  DT.92446899 

Selected AceView cDNA sequences (see all 248):

AV661354 AV659487 AI431430 AA344005 BG569502 AA345584 AA345587 AA343486 
BG616481 AA345783 AA345182 AA345474 AI571524 BG616499 BE138817 AV658544 
AA344672 T40091 BG569474 AA345628 T61726 AV659299 AA343521 AA343439 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for CRP (see all 8)    About this scheme

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f
SP1:                    -                 -                                             
SP2:                    -                 -     -                                       
SP3:                    -     -           -                                             
SP4:                    -     -           -     -     -                                 
SP5:                    -     -                                                         


ECgene alternative splicing isoforms for CRP

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CRP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GAGAGAGACT
CRP Expression
About this image


CRP expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 2) fully expand
 
 Liver (Hepatobiliary System)
         Hepatocytes Liver Lobule
 
 Gall Bladder (Hepatobiliary System)
CRP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

CRP Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.76452

UniProtKB/Swiss-Prot: CRP_HUMAN, P02741
Tissue specificity: Found in plasma

    Pathway & Disease-focused RT2 Profiler PCR Arrays including CRP (see all 8): 
          Inflammatory Response & Autoimmunity in human mouse rat
          JAK / STAT Signaling Pathway in human mouse rat
          Inflammatory Response & Autoimmunity 384HT in human mouse rat
          Stress & Toxicity PathwayFinder in human mouse rat
          Antibacterial Response in human mouse rat

Primer
Products:
OriGene qSTAR qPCR primer pairs in human, mouse for CRP
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CRP
QuantiTect SYBR Green Assays in human, mouse, rat CRP
QuantiFast Probe-based Assays in human, mouse, rat CRP
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRP

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for CRP gene from Selected species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Crp1 , 5 C-reactive protein, pentraxin-related1, 5 76.08(n)1
70.4(a)1
  1 (80.13 cM)5
129441  NM_007768.41  NP_031794.31 
 1726980565 
chicken
(Gallus gallus)
Aves CRP1 C-reactive protein, pentraxin-related 55.71(n)
48.15(a)
  429786  NM_001039564.1  NP_001034653.1 
lizard
(Anolis carolinensis)
Reptilia --
--
(see all 6)
Uncharacterized protein
(see all 6)
46(a)
45(a)
(see all 6)
many ↔ many
many ↔ many
(see all 6)
GL344144.1(41421-44569)
GL343640.1(33299-47988)
African clawed frog
(Xenopus laevis)
Amphibia Xl.162192 Xenopus laevis transcribed sequence with weak similarity more 81.38(n)    BJ035031.1 
zebrafish
(Danio rerio)
Actinopterygii CRP6
C-reactive protein, pentraxin-related
21(a)
1 → many
13(20508374-20510467) ENSDARG00000045089


ENSEMBL Gene Tree for CRP (if available)
TreeFam Gene Tree for CRP (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for CRP gene
NPTX22  APCS2  PTX42  NPTX12  NPTXR2  PTX32  
3 SIMAP similar genes for CRP using alignment to 3 protein entries:     CRP_HUMAN (see all proteins):
APCS    MPTX1    NPTX1

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1 Pseudogenes.org Pseudogene for CRP
PGOHUM00000244305


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for CRP (see all 153)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1999538541,2
Cuntested1166179776(+) GCTGGG/TCAAGA 2 T P mis10--------
rs585183861,2
C--159684122(+) CAGTC-/TTTTTT 1 -- int10--------
rs1504608661,2
--166177229(+) CTGGAG/TGAAGC 1 -- ds50010--------
rs30930801,2
C,F,H--166177274(-) TCAAGT/ATCTTT 1 -- ds500112Minor allele frequency- A:0.01NS EA NA 1612
rs28086311,2
C,F--166177567(+) GTTAGT/CCACAA 1 -- ds50016Minor allele frequency- C:0.03NS NA WA 1970
rs1116260411,2
C--166177604(+) CTTGGT/ACTCAC 1 -- ds50011Minor allele frequency- A:0.00CSA 1
rs12051,2
C,F,O,A,H--166177764(+) CCTCAC/TAGTCT 1 -- ut31 ese335Minor allele frequency- T:0.34NA MN NS EA CSA WA 6743
rs64134671,2
C,F,H--166177773(-) CATGGA/TGAGAG 1 -- ut3113Minor allele frequency- T:0.01MN NS EA NA WA 1116
rs178604771,2
--166177816(+) TTCACA/GTCCTC 1 -- ut31 ese30--------
rs31166401,2
C--166177845(-) ATCTTC/TTTGCT 1 -- ut315Minor allele frequency- T:0.00MN 404

HapMap Linkage Disequilibrium report for CRP (159682079 - 159684379 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for CRP:    About this table    
Variant IDTypeSubtypePubMed ID
nsv825076CNV Loss20364138

Human Gene Mutation Database (HGMD): CRP
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing CRP
DNA2.0 Custom Variant and Variant Library Synthesis for CRP

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 123260    OMIM disorders: --

Selected diseases for CRP (see all 104):    
About MalaCards
pneumonia    appendicitis    epidural abscess    aortitis
ulcerative proctitis    suppurative cholangitis    hypersensitivity vasculitis    pyuria
lymphoid interstitial pneumonia    pulmonary aspergilloma    chronic meningitis    neonatal meningitis
meningitis    suppurative otitis media    sepsis    mononeuritis
mononeuritis multiplex    cryoglobulinemic vasculitis    meningitis and encephalitis    sepsis in premature infants

Selected diseases from the University of Copenhagen DISEASES database for CRP (see all 58):
Heart disease     Atherosclerosis     Diabetes mellitus     Rheumatoid arthritis
Hypertension     Cerebrovascular accident     Pneumonia     Appendicitis
Crohn's disease     Kidney failure     Vasculitis     Ankylosing spondylitis
Osteomyelitis     Meningitis     Anemia     Pancreatitis
Septic arthritis     Kawasaki disease     Periodontal disease     Ulcerative colitis

Find genes that share disorders with CRP           About GenesLikeMe

Selected Novoseek inferred disease relationships for CRP gene (see all 92)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
inflammation 92.2 2306 15496560 (5), 15550763 (4), 19272152 (4), 15472532 (4) (see all 99)
response acute phase 90 247 14634117 (3), 10353472 (3), 1699702 (3), 14743546 (3) (see all 99)
cardiovascular diseases 85.5 685 15529024 (6), 12823355 (4), 18855714 (4), 10393687 (4) (see all 99)
rheumatoid arthritis 84.5 150 16489709 (3), 8539481 (2), 17516213 (2), 20433772 (2) (see all 99)
atherosclerosis 84.4 572 12468765 (5), 17576871 (4), 11448405 (3), 16526209 (3) (see all 99)
necrosis 76.9 783 20447537 (3), 20499416 (3), 12732100 (3), 2014508 (3) (see all 99)
insulin resistance 76.2 399 15542929 (5), 19188739 (5), 15983332 (4), 19680627 (4) (see all 99)
coronary heart disease 75.6 345 19567438 (7), 12796068 (5), 18178405 (3), 16290959 (3) (see all 99)
coronary artery disease 74.5 220 19463117 (4), 11703959 (3), 9781965 (3), 12587783 (2) (see all 99)
systemic inflammatory response syndrome 73.3 41 15073705 (1), 15990980 (1), 16078967 (1), 17260130 (1) (see all 35)

Genetic Association Database (GAD): CRP
Human Genome Epidemiology (HuGE) Navigator: CRP (666 documents)

Export disorders for CRP gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for CRP gene, integrated from 10 sources (see all 6371):
(articles sorted by number of sources associating them with CRP)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Characterization of genomic and complementary DNA sequence of human C-reactive protein, and comparison with the complementary DNA sequence of serum amyloid P component. (PubMed id 3840479)1, 2, 3 Woo P.... Whitehead A.S. (J. Biol. Chem. 1985)
  2. Isolation of human C-reactive protein complementary DNA and localization of the gene to chromosome 1. (PubMed id 6857266)1, 2, 3 Whitehead A.S.... Woods D.E. (Science 1983)
  3. Inflammation, insulin resistance, and diabetes--Mendelian randomization using CRP haplotypes points upstream. (PubMed id 18700811)1, 4, 9 Brunner E.J....Kumari M. (PLoS Med. 2008)
  4. Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease. (PubMed id 19567438)1, 4, 9 Elliott P....Kooner J.S. (JAMA 2009)
  5. Polymorphisms of the CRP gene inhibit inflammatory response and increase susceptibility to depression: the Health in Men Study. (PubMed id 19433520)1, 4, 9 Almeida O.P....Flicker L. (Int J Epidemiol 2009)
  6. The interaction of adiposity with the CRP gene affects CRP levels: age, gene/environment susceptibilty-Reykjavik study. (PubMed id 19139754)1, 4, 9 Eiriksdottir G....Gudnason V. (Int J Obes (Lond) 2009)
  7. The association of C-reactive protein and CRP genotype with coronary heart disease: findings from five studies with 4,610 cases amongst 18,637 participants. (PubMed id 18714384)1, 4, 9 Lawlor D.A....Smith G.D. (PLoS ONE 2008)
  8. Association between C-reactive protein gene haplotypes and C-reactive protein levels in Taiwanese: interaction with obesity. (PubMed id 19101671)1, 4, 9 Teng M.S....Ko Y.L. (Atherosclerosis 2009)
  9. Association of common C-reactive protein (CRP) gene polymorphisms with baseline plasma CRP levels and fenofibrate response: the GOLDN study. (PubMed id 18285551)1, 4, 9 Shen J....Ordovas J.M. (Diabetes Care 2008)
  10. Epistatic effect of C-reactive protein (CRP) single nucleotide polymorphism (SNP) +1059 and interleukin-1B SNP +3954 on CRP concentration in healthy male blood donors. (PubMed id 16026589)1, 4, 9 Eklund C....Hurme M. (Int. J. Immunogenet. 2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1401 HGNC: 2367 AceView: CRP Ensembl:ENSG00000132693 euGenes: HUgn1401
ECgene: CRP H-InvDB: CRP

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for CRP Pharmacogenomics, SNPs, Pathways
Wikipedia http://en.wikipedia.org/wiki/C-reactive_protein
SeattleSNPshttp://pga.gs.washington.edu/data/crp/
Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/030

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for CRP gene:
Search GeneIP for patents involving CRP

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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