External Ids for CRP Gene
Previous GeneCards Identifiers for CRP Gene
The protein encoded by this gene belongs to the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. [provided by RefSeq, Sep 2009]
GeneCards Summary for CRP Gene
CRP (C-Reactive Protein, Pentraxin-Related) is a Protein Coding gene. Diseases associated with CRP include acute pancreatitis and appendicitis. Among its related pathways are Activation of cAMP-Dependent PKA and Creation of C4 and C2 activators. GO annotations related to this gene include calcium ion binding and cholesterol binding. An important paralog of this gene is NPTX1.
UniProtKB/Swiss-Prot for CRP Gene
Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.