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CRP Gene

protein-coding GIFtS: 68

GC01M157948

C-reactive protein, pentraxin-related
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
MGC149895 ^²
MGC88244 ^²
OTTHUMP00000033307 ^²
PTX1 ^¹, ², ³

Descriptions
C-reactive protein, pentraxin-related ^²

External Ids
HGNC: 2367¹
Entrez Gene: 1401²
UniProtKB: P02741³
Ensembl: ENSG00000132693⁷

Search outside databases for aliases for CRP gene

Previous GC identifers: GC01M157474 GC01M155414 GC01M156459 GC01M156899 GC01M156495

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: CRP_HUMAN, P02741

Function: Displays several functions associated with host defense: it promotes agglutination,

bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent

binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material

released from damaged circulating cells

Gene Wiki entry for CRP (C-reactive_protein)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CRP gene

Entrez Gene cytogenetic band: 1q21-q23 Ensembl cytogenetic band: 1q23.2 HGNC cytogenetic band: 1q21-q23

CRP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M157948: (about GC identifiers)

Start:	157,948,703 bp from pter
End:	157,951,003 bp from pter
Size:	2,301 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000001.9 NT_004487.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: CRP_HUMAN, P02741 (See protein sequence)

Recommended Name: C-reactive protein precursor

Size: 224 amino acids; 25039 Da

Cofactor: Binds 2 calcium ions per subunit

Subunit: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound

subunits

Subcellular location: Secreted

Mass spectrometry: Mass=23028; Method=MALDI; Range=19-224; Source=Ref.14;

Mass spectrometry: Mass=22930; Method=MALDI; Range=19-223; Source=Ref.14;

Miscellaneous: This protein owes its name to its ability precipitate pneumococcal C-polysaccharide

in the presence of calcium

PDB structures from and Proteopedia :

1B09 (3D)

1CRV (3D)

1GNH (3D)

1LJ7 (3D)

Secondary accessions: A8K078 Q08AK3 Q8WW75

Alternative splicing: 2 isoforms: P02741-1 P02741-2

REFSEQ proteins: NP_000558.2

ENSEMBL proteins:

ENSP00000255030 ENSP00000340882 ENSP00000357093 ENSP00000357092 ENSP00000357091

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant CRP Protein
	Sigma-Aldrich Proteins for CRP
	R&D Systems Recombinant & Natural Proteins for CRP (C-Reactive Protein/CRP)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (C Reactive Protein)
	Human Recombinant Proteins from Abnova (CRP)

OriGene Purified Recombinant Human Protein: CRP

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	NAS	14718574

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Antibodies for CRP:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of CRP
	Sigma-Aldrich Antibodies for CRP
	R&D Systems Antibodies for CRP (C-Reactive Protein/CRP)
	Antibodies from Abcam (C Reactive Protein), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (CRP)
	Novus Biologicals Antibodies for CRP

Assays for CRP:

	Invitrogen Assays for CRP
	Millipore Kits and Assays for the Analysis of CRP
	R&D Systems ELISAs for CRP (C-Reactive Protein/CRP) (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P02741

ProtoNet protein and cluster: P02741

1 Blocks protein family: IPB001759 Pentaxin

UniProtKB/Swiss-Prot: CRP_HUMAN, P02741

Similarity: Belongs to the pentaxin family

Similarity: Contains 1 pentaxin domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CRP)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CRP)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000567

Applied Biosystems Silencer® siRNAs for CRP

Sigma-Aldrich siRNA for CRP

Sigma-Aldrich shRNA for CRP

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for CRP
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000567
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000567
untagged cDNA clone in CMV expression vector: NM_000567

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000567

UniProtKB/Swiss-Prot: CRP_HUMAN, P02741

Function: Displays several functions associated with host defense: it promotes agglutination,

bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent

binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material

released from damaged circulating cells

Induction: The concentration of CRP in plasma increases greatly during acute phase response to

tissue injury, infection or other inflammatory stimuli. It is induced by IL-1 and IL-6

Genatlas biochemistry entry for CRP:

C-reactive protein,acute phase reactant,pentaxin (pentraxin) family,bacterial catabolite activator

protein

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005509	calcium ion binding	IEA	--
GO:0005515	protein binding	IPI	17785206
GO:0030169	low-density lipoprotein binding	IDA	18322245
GO:0033265	choline binding	TAS	2477488
GO:0051637	Gram-positive bacterial cell surface binding	TAS	2477488

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for CRP (Your Favorite Gene powered by Ingenuity)

IL-17 Signaling
Acute Phase Response Signaling

GeneDecks CRP for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for CRP

5/103 Interacting proteins for CRP (P02741^{1, 2} ENSP00000255030³) via UniProtKB, MINT, and/or STRING (see all 103 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FCGR2A	P12318¹, ENSP00000271450³	EBI-1395983, EBI-1395970 STRING (score=.994)
ENSG00000204319	ENSP00000372814³	STRING (score=.805) STRING (score=.805)
FCGR2C	P31995¹	EBI-1395983, EBI-1396036
FCN2	Q15485²	MINT-5223188
CFH	ENSP00000356399³	STRING (score=.982)

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5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006953	acute-phase response	IEA	--
GO:0006954	inflammatory response	TAS	10408362
GO:0008228	opsonization	TAS	2477488
GO:0010745	negative regulation of foam cell differentiation	IDA	18322245
GO:0045833	negative regulation of lipid metabolic process	IDA	18322245

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for CRP
10/33 Novoseek chemical compound relationships for CRP gene (see all 33 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
fibrinogen	86.75	1531	12738395 (10), 16703188 (8), 11427220 (7), 16698114 (7) (see all 99)
cholesterol	78.87	1167	15635109 (8), 15766555 (7), 17996517 (6), 12102655 (5) (see all 99)
homocysteine	73.89	402	17852421 (7), 15051846 (6), 18311078 (5), 12788842 (5) (see all 99)
neopterin	71.14	232	18541395 (7), 1764778 (5), 15848499 (5), 15253949 (5) (see all 87)
aopp	66.37	58	18786315 (7), 17058827 (4), 15354943 (3), 14739577 (3) (see all 20)
phosphorylcholine	64.23	223	7979374 (9), 12218140 (8), 1704398 (7), 12244213 (6) (see all 57)
glucose	63.62	728	14706052 (7), 18691271 (7), 19130414 (5), 15955391 (5) (see all 99)
lipid	63.04	478	17356986 (5), 16775668 (5), 12542120 (5), 18940224 (4) (see all 99)
uric acid	55.39	167	16079884 (6), 17599452 (5), 16251237 (5), 16611716 (4) (see all 90)
p002	54.16	65	12801614 (2), 12161055 (2), 16231577 (2), 11781754 (1) (see all 45)

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2 PharmGKB drug compound relationships for CRP gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
omega-3 polyunsaturated fatty acids	PD	12654170 11703959
statin	CO PD	15635109 11952885 12595863

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CRP)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CRP)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000567

Sigma-Aldrich siRNA for CRP

Sigma-Aldrich shRNA for CRP

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000567

REFSEQ mRNAs for CRP gene:

NM_000567.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000567

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000567
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000567
                                 untagged cDNA clone in CMV expression vector: NM_000567

Additional cDNA sequence:

BC020766.1 BC070257.1

16 DOTS entries:

DT.448901 DT.102829615 DT.100826852 DT.100826853 DT.92446899 DT.92446914 DT.100826854 DT.92446905

DT.92446889 DT.92446887 DT.92446904 DT.92446908 DT.95111437 DT.95111452 DT.95111466 DT.92446903

24/248 AceView cDNA sequences (see all 248 ):

AA344310 AA344672 AV658544 AA343486 AW192271 AV653853 AA343521 BG568547

BG616481 T61726 BG569474 AA345584 AA344442 AA343492 AA345587 AI571524

CB146596 AA345050 AV661354 AA345783 AA343520 CR598604 AA345681 AI431430

highest scoring ESTs for CRP:

X56692 AA343439 AA343492 AA343521 AA343738 AA343870 AA344005 AA344022 AA344098 AA344196

Unigene Clusters for CRP:

C-reactive protein, pentraxin-related

Hs.76452 [show with all ESTs], Hs.709456 [show with all ESTs]

Unigene Representative Sequences: NM_000567, BC070257

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CRP (see all 8 )

ExUns:	1	^	2a	·	2b	^	3	^	4a	·	4b	·	4c	^	5	^	6a	·	6b	·	6c	·	6d	·	6e	·	6f
SP1:							-						-
SP2:							-						-		-
SP3:							-		-				-
SP4:							-		-				-		-		-
SP5:							-		-

About this scheme

ECgene alternative splicing isoforms for CRP

5 Ensembl transcripts including schematic representations:

ENST00000255030 ENST00000343919 ENST00000368112 ENST00000368111 ENST00000368110

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CRP expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CRP

¹ / ² / ³

5 probe-sets matching CRP gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
37020_at²^{, 3}	U133-A	2	1.00	0.97	1.00	1.00	X56692	1.00	1.00	1.00	1
205753_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000567	0.60	1.00	0.82	1
37020_at²^{, 3}	U133-A	2	1.00	0.97	--	--	X56692	1.00	1.00	1.00	1
205753_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
37020_at²	U133Plus2	2	1.00	0.97	--	--	--	--	--	--	--

GeneDecks CRP for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene clusters: Hs.76452 Hs.709456
Expression variation in blood from EXPOLDB for CRP
UniProtKB/Swiss-Prot: CRP_HUMAN, P02741
Tissue specificity: Found in plasma

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CRP gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CRP¹	--	C-reactive protein, pentraxin-related	66.98(n) 60.47(a)	488629 XM_545746.2 XP_545746.2
chimpanzee (Pan troglodytes)	CRP¹	--	C-reactive protein, pentraxin-related	99.55(n) 99.11(a)	457428 XM_513917.2 XP_513917.2
cow (Bos taurus)	CRP¹	--	C-reactive protein, pentraxin-related	79.07(n) 70.4(a)	527553 XM_605946.3 XP_605946.2
rat (Rattus norvegicus)	Crp¹	--	C-reactive protein, pentraxin-related	74.17(n) 67.12(a)	25419 NM_017096.2 NP_058792.1
mouse (Mus musculus)	Crp^{1, 5}	1 (94.20 cM)⁵	C-reactive protein, pentraxin-related^{1, 5}	75.93(n)¹ 70.4(a)¹	12944¹ NM_007768.3¹ NP_031794.2¹ AI255847⁵ AK088477⁵ (see all 9)

About this table Species with no ortholog for CRP

ENSEMBL Gene Tree for CRP

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for CRP gene

APCS² C16orf38² PTX3²

Pseudogenes

2 related pseudogenes

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/76 NCBI SNPs in CRP are shown (see all 76 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 65)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1130864^1,2	A,C,F,H,O	157949715(-)	`GGAAAC/TGGTCC`	1	--	ut3¹		10	NS EU EA WA NA	4390
	rs1205^1,2	A,C,F,H,O	157948857(+)	`CCTCAC/TAGTCT`	1	--	ut3¹ ese³		18	NA MN EU EA WA NS CSAM	2668
--	rs3093059^1,2	C,F,H,O	157951760(-)	`TCAATC/TGGCTG`	1	--	ng3¹		12	NS EA WA NA	1970
--	rs6413466^1,2	C,F,H	157949049(-)	`YCTCCC/TATCTC`	1	--	ut3¹ ese³		10	MN CSAM EA EU WA NS	900
	rs6413467^1,2	C,F,H	157948866(-)	`CATGGA/TGAGAG`	1	--	ut3¹		10	MN CSAM EA EU WA NS	994
	rs3093063^1,2	C,F,H	157951097(-)	`GACACC/TTGCCC`	1	--	ng3¹		13	NS EU EA WA MN CSAM	1236
	rs3093066^1,2	C,F,H	157949723(-)	`CTATGC/ATGGGA`	1	--	ut3¹		11	NS EU EA WA NA	1480
--	rs2794521^1,2	A,C,F	157951720(+)	`gaacaT/Cgcggt`	1	--	ng3¹		4	NS	648
	rs3093062^1,2	C,F,H	157951308(-)	`ACCACG/ATGCAC`	1	--	ng3¹ tfbs³		12	NS EU EA MN CSAM	1680
	rs3093058^1,2	C,F,H	157951939(-)	`GAAAGA/TGTAGA`	1	--	ng3¹ trp³		15	NS EU EA WA	2980

About this table

HapMap Linkage Disequilibrium images for CRP (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 123260

10/93 Novoseek disease relationships for CRP gene (see all 93 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
inflammation	91.70	2040	15496560 (5), 15550763 (4), 19272152 (4), 15472532 (4) (see all 99)
response acute phase	90.03	240	14634117 (3), 10353472 (3), 1699702 (3), 14743546 (3) (see all 99)
cardiovascular diseases	84.59	602	15529024 (6), 12823355 (4), 18855714 (4), 10393687 (4) (see all 99)
atherosclerosis	83.70	494	12468765 (5), 17576871 (4), 11448405 (3), 16526209 (3) (see all 99)
rheumatoid arthritis	83.56	131	16489709 (3), 8539481 (2), 17516213 (2), 10986307 (2) (see all 99)
necrosis	75.89	676	12732100 (3), 2014508 (3), 7517087 (2), 16923454 (2) (see all 99)
coronary heart disease	74.73	286	12796068 (5), 18178405 (3), 12835213 (3), 18930961 (3) (see all 99)
insulin resistance	74.73	344	15542929 (5), 19188739 (5), 15983332 (4), 18360022 (4) (see all 99)
coronary artery disease	73.53	195	11703959 (3), 9781965 (3), 12587783 (2), 15136066 (2) (see all 99)
bacterial infections	72.03	218	18534215 (6), 10530060 (5), 12149826 (5), 8038314 (4) (see all 99)

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4 PharmGKB disease relationships for CRP gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Cardiovascular Diseases	CO PD	15635109
Coronary Disease	CO PD GN	15517131 11703959
Diabetes Mellitus, Non-Insulin-Dependent	CO GN	12618085
Hypercholesterolemia	PD	11952885

About this table

Human Gene Mutation Database: CRP
Genetic Association Database: CRP
Human Genome Epidemiology Navigator: CRP (429 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/4746 PubMed articles for CRP gene (see all 4746 ):

-717A>G polymorphism of human C-reactive protein gene associated with coronary heart disease in ethnic Han Chinese: the Beijing atherosclerosis study. (PubMed id 15517131)^{3, 6, 7} Chen J....Gu D. (2005)
A C-reactive protein promoter polymorphism is associated with type 2 diabetes mellitus in Pima Indians. (PubMed id 12618085)^{3, 6, 7} Wolford J.K....Hanson R.L. (2003)
Characterization of genomic and complementary DNA sequence of human C-reactive protein, and comparison with the complementary DNA sequence of serum amyloid P component. (PubMed id 3840479)^{2, 3, 4} Woo P.... Whitehead A.S. (1985)
Isolation of human C-reactive protein complementary DNA and localization of the gene to chromosome 1. (PubMed id 6857266)^{2, 3, 4} Whitehead A.S....Woods D.E. (1983)
Epistatic effect of C-reactive protein (CRP) single nucleotide polymorphism (SNP) +1059 and interleukin-1B SNP +3954 on CRP concentration in healthy male blood donors. (PubMed id 16026589)^{1, 3, 6} Eklund C....Hurme M. (2005)
Relation of polymorphism within the C-reactive protein gene and plasma CRP levels. (PubMed id 15585211)^{1, 3, 6} Suk H.J....Zee R.Y. (2005)
Single-nucleotide polymorphisms in the C-reactive protein (CRP) gene promoter that affect transcription factor binding, alter transcriptional activity, and associate with differences in baseline serum CRP level. (PubMed id 15778807)^{1, 3, 6} Szalai A.J....Kimberly R.P. (2005)
Association between baseline levels of C-reactive protein (CRP) and a dinucleotide repeat polymorphism in the intron of the CRP gene. (PubMed id 11857055)^{1, 3, 6} Szalai A.J....Kimberly R.P. (2002)
C-reactive protein genotypes affect baseline, but not exercise training-induced changes, in C-reactive protein levels. (PubMed id 15271790)^{1, 3, 6} Obisesan T.O....Hagberg J.M. (2004)
The physiological structure of human C-reactive protein and its complex with phosphocholine. (PubMed id 10368284)^{1, 3, 4} Thompson D.... Wood S.P. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 1401	HGNC: 2367	AceView: CRP	Ensembl:ENSG00000132693	euGenes: HUgn1401
ECgene: CRP	H-InvDB: CRP

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
Wikipedia	http://en.wikipedia.org/wiki/C-reactive_protein
SeattleSNPs	http://pga.gs.washington.edu/data/crp/
Protein Spotlight	http://www.expasy.org/spotlight/back_issues/sptlt030.shtml

Licensable Technologies for CRP
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for CRP:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

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Antibodies for CRP

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
CRP Gene at Home site.
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CRP Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for CRP

Summaries
for CRP

Genomic Location
for CRP

Proteins
for CRP

Protein Domains/
Families
for CRP

Gene Function
for CRP

Pathways & Interactions
for CRP

Drugs & Compounds
for CRP

Transcripts
for CRP

Expression
for CRP

Orthologs
for CRP

Paralogs
for CRP

SNPs/Variants
for CRP

Disorders & Mutations
for CRP

Medical News
for CRP

Publications
for CRP

Search for CRP

Genome Databases showing CRP

Other Databases showing CRP

Specialized Databases showing CRP

Licensable Technologies
for CRP

Services
for CRP

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CRP Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor CRP

Summariesfor CRP

Genomic Locationfor CRP

Proteinsfor CRP

Protein Domains/Familiesfor CRP

Gene Functionfor CRP

Pathways & Interactionsfor CRP

Drugs & Compoundsfor CRP

Transcriptsfor CRP

Expression for CRP

Orthologsfor CRP

Paralogsfor CRP

SNPs/Variantsfor CRP

Disorders & Mutationsfor CRP

Medical Newsfor CRP

Publicationsfor CRP

Search for CRP

Genome Databases showing CRP

Other Databases showing CRP

Specialized Databases showing CRP

Licensable Technologiesfor CRP

Servicesfor CRP

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CRP

Summaries
for CRP

Genomic Location
for CRP

Proteins
for CRP

Protein Domains/
Families
for CRP

Gene Function
for CRP

Pathways & Interactions
for CRP

Drugs & Compounds
for CRP

Transcripts
for CRP

Expression
for CRP

Orthologs
for CRP

Paralogs
for CRP

SNPs/Variants
for CRP

Disorders & Mutations
for CRP

Medical News
for CRP

Publications
for CRP

Licensable Technologies
for CRP

Services
for CRP