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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CRP Gene

protein-coding GIFtS: 67
GCID: GC01M159682

C-reactive protein, pentraxin-related

Explore 456 diseases affiliated with
CRP via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
C-Reactive Protein, Pentraxin-Related¹ ²
PTX1¹ ² ³
C-Reactive Protein²
Pentraxin 1²

External Ids:	HGNC: 2367¹	Entrez Gene: 1401²	Ensembl: ENSG00000132693⁷	OMIM: 123260⁵	UniProtKB: P02741³

Export aliases for CRP gene to outside databases

Previous GC identifers: GC01M157474 GC01M155414 GC01M156459 GC01M156899 GC01M156495 GC01M157948 GC01M131038

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CRP:

The protein encoded by this gene belongs to the pentaxin family. It is involved in several host defense related

functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their

elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this

protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory

stimuli. (provided by RefSeq, Sep 2009)

UniProtKB/Swiss-Prot: CRP_HUMAN, P02741

Function: Displays several functions associated with host defense: it promotes agglutination, bacterial capsular

swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can

interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells

Gene Wiki entry for CRP (C-reactive protein)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004487.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CRP gene promoter:
Max1 TBP FOXO3 CUTL1 Nkx2-5 FOXO3b AREB6 FOXO3a c-Myc
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CRP promoter sequence

Search SABiosciences Chromatin IP Primers for CRP

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CRP

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21-q23 Ensembl cytogenetic band: 1q23.2 HGNC cytogenetic band: 1q21-q23

CRP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRP gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M159682: view genomic region (about GC identifiers)

Start:	159,682,079 bp from pter	End:	159,684,379 bp from pter
Size:	2,301 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CRP_HUMAN, P02741 (See protein sequence)

Recommended Name: C-reactive protein precursor

Size: 224 amino acids; 25039 Da

Cofactor: Binds 2 calcium ions per subunit

Subunit: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits

Subcellular location: Secreted

Mass spectrometry: Mass=23028; Method=MALDI; Range=19-224; Source=Ref.15;

Mass spectrometry: Mass=22930; Method=MALDI; Range=19-223; Source=Ref.15;

Miscellaneous: This protein owes its name to its ability precipitate pneumococcal C-polysaccharide in the presence of

calcium

6/7 PDB 3D structures from and Proteopedia for CRP (see all 7):

1B09 (3D)

1CRV (3D)

1GNH (3D)

1LJ7 (3D)

3L2Y (3D)

3PVN (3D)

Secondary accessions: A8K078 D3DVD9 D3DVE0 Q08AK3 Q8WW75

Alternative splicing: 2 isoforms: P02741-1 P02741-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CRP: NX_P02741

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P02741

CRP Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000558.2

ENSEMBL proteins:

ENSP00000255030 ENSP00000357093 ENSP00000357092 ENSP00000357091 ENSP00000340882

ENSP00000402788

Human Recombinant Protein Products for CRP:

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	OriGene Purified Protein: CRP OriGene Protein Over-expression Lysate: CRP OriGene Custom Protein Services for CRP
	GenScript Custom Purified and Recombinant Proteins Services for CRP
	Novus Biologicals CRP Proteins Novus Biologicals CRP Lysates
	Sino Biological Recombinant Protein for CRP
	ProSpec Recombinant Protein for CRP
	Uscn Proteins for CRP

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	NAS	14718574
GO:0005615	extracellular space	IEA	--
GO:0005739	mitochondrion	IEA	--
GO:0005886	plasma membrane	IEA	--
GO:0030175	filopodium	IEA	--

CRP for ontologies About GeneDecksing

CRP Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of CRP
	R&D Systems Antibodies for CRP (C-Reactive Protein/CRP)
	OriGene Antibodies (see all 2): CRP OriGene Custom Antibody Services for CRP
	GenScript Superior Antibodies for CRP
	Novus Biologicals CRP Antibodies
	Abcam antibodies for CRP
	Uscn Antibodies for CRP
	ThermoFisher Antibodies for CRP

Assay Products for CRP:

	EMD Millipore Kits and Assays for the Analysis of CRP
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for CRP (C-Reactive Protein/CRP) (see all)
	GenScript Custom Assay Services for CRP
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CRP

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CRP for domains About GeneDecksing

3 InterPro domains/families:

IPR013320 ConA-like_subgrp

IPR001759 Pentaxin

IPR008985 ConA-like_lec_gl_sf

Graphical View of Domain Structure for InterPro Entry P02741

ProtoNet protein and cluster: P02741

1 Blocks protein family: IPB001759 Pentaxin

UniProtKB/Swiss-Prot: CRP_HUMAN, P02741

Similarity: Belongs to the pentaxin family

Similarity: Contains 1 pentaxin domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CRP_HUMAN, P02741

Function: Displays several functions associated with host defense: it promotes agglutination, bacterial capsular

swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can

interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells

Induction: The concentration of CRP in plasma increases greatly during acute phase response to tissue injury, infection

or other inflammatory stimuli. It is induced by IL1/interleukin-1 and IL6//interleukin-6

Genatlas biochemistry entry for CRP:

C-reactive protein,acute phase reactant,pentaxin (pentraxin) family,bacterial catabolite activator protein

Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005488	binding	--	--
GO:0005515	protein binding	IPI	17785206
GO:0015485	cholesterol binding	IEA	--
GO:0030169	low-density lipoprotein particle binding	IDA	18322245
GO:0033265	choline binding	TAS	2477488

CRP for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for CRP:

Synthetic lethal with c-Myc af

3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Crp):

cardiovascular system

homeostasis/metabolism

immune system

CRP for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Crp^tm1Hjf for CRP

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CRP

miRNA Products:		OriGene 3'-UTR Clone: CRP Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CRP
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate CRP:
		hsa-miR-637 hsa-miR-218-1*
		SwitchGear 3'UTR luciferase reporter plasmid: CRP 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CRP (see all 7) OriGene shRNA RFP: CRP OriGene siRNA: CRP
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CRP
		Sirion Biotech Custom design and validation of potent shRNA sequences against CRP

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for CRP
			Sirion Biotech Customized adenovirus for overexpression of CRP Sirion Biotech Customized adenovirus for potent knockdown of CRP

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CRP (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CRP OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript Custom all cDNA clones Services for CRP
		Sino Biological Human cDNA Clone for CRP
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRP
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRP

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CRP
		Search LifeMap BioReagents cell lines for CRP
		Sirion Biotech Customized stable knockdown cell line services for CRP Sirion Biotech Customized inducible knockdown cell line services for CRP Sirion Biotech Customized stable overexpressing cell line services for CRP Sirion Biotech Customized inducible overexpressing cell line services for CRP

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRP

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Activation of cAMP-Dependent PKA

	Activation of cAMP-Dependent PKA	1.00			Activation of PKA through GPCR	0.71
	cAMP Pathway	0.77			PKA Signaling	0.56

Immune response_Classical complement pathway

Immune response_Classical complement pathway

1.00

Immune response Classic complement pathway

0.98

Development Thrombopoetin signaling via JAK-STAT pathway

Development Thrombopoetin signaling via JAK-STAT pathway

1.00

Development_Thrombopoetin signaling via JAK-STAT pathway

1.00

Development_CNTF receptor signaling

Development_Leptin signaling via JAK/STAT and MAPK cascades

0.25

Development Leptin signaling via JAK/STAT and MAPK cascades

0.25

Selected targets of HNF1

Selected targets of HNF1

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

4 EMD Millipore Pathways for CRP

	Immune response Classic complement pathway
	Development Leptin signaling via JAK/STAT and MAPK cascades
	Selected targets of HNF1
	Development Thrombopoetin signaling via JAK-STAT pathway

4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CRP

	Activation of PKA through GPCR
	PKA Signaling
	cAMP Pathway
	Activation of cAMP-Dependent PKA

3 GeneGo (Thomson Reuters) Pathways for CRP

	Development Leptin signaling via JAK/STAT and MAPK cascades
	Immune response Classical complement pathway
	Development Thrombopoetin signaling via JAK-STAT pathway

2 BioSystems Pathways for CRP

	Selenium Pathway
	IL6-mediated signaling events

CRP for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CRP

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/38 Interacting proteins for CRP (P02741^{1, 2, 3} ENSP00000255030⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 38)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FCGR2C	P31995¹^,³	EBI-1395983,EBI-1396036 I2D: score=1
HIST1H2AG	P0C0S8³, ENSP00000352119⁴	I2D: score=1 STRING: ENSP00000352119
HIST1H2AI	P0C0S8³	I2D: score=1
HIST1H2AK	P0C0S8³	I2D: score=1
HIST1H2AL	P0C0S8³	I2D: score=1

About this table

Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001666	response to hypoxia	IEA	--
GO:0006953	acute-phase response	TAS	2477488
GO:0006954	inflammatory response	TAS	10408362
GO:0006958	complement activation, classical pathway	IEA	--
GO:0007568	aging	IEA	--

CRP for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CRP for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CRP

3 HMDB Compounds for CRP About this table

Compound	Synonyms	CAS #	PubMed Ids
Atorvastatin	Atorvastatin acid (see all 4)	134523-00-5	--
Calcium	Ca (see all 2)	7440-70-2	--
Phosphorylcholine	Choline phosphate (see all 5)	3616-04-4	--

1 DrugBank Compound for CRP About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Phosphocholine	--	107-73-3	target	--	17139284 17016423

10/134 Novoseek chemical compound relationships for CRP gene (see all 134) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
fibrinogen	87.4	1760	12738395 (10), 16703188 (8), 11427220 (7), 16698114 (7) (see all 99)
cholesterol	80.1	1366	15635109 (8), 15766555 (7), 17996517 (6), 12102655 (5) (see all 99)
homocysteine	75	478	17852421 (7), 19362308 (7), 15051846 (6), 18311078 (5) (see all 99)
neopterin	71.9	258	18541395 (7), 1764778 (5), 15848499 (5), 19282816 (5) (see all 96)
creatinine	69.4	495	14655192 (5), 12748357 (5), 15811980 (5), 18609082 (4) (see all 99)
infliximab	69	89	16344720 (5), 15641046 (5), 15485995 (4), 15958758 (4) (see all 37)
atorvastatin	68.4	151	12595863 (5), 15843280 (5), 12009719 (4), 18991814 (4) (see all 72)
glucose	66	838	14706052 (7), 18691271 (7), 19130414 (5), 15955391 (5) (see all 99)
aopp	65.1	65	18786315 (7), 17058827 (4), 15354943 (3), 18976759 (3) (see all 22)
lipid	64.8	562	19621193 (6), 17356986 (5), 12542120 (5), 16775668 (5) (see all 99)

Search CenterWatch for drugs/clinical trials and news about CRP

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CRP gene:

NM_000567.2

Unigene Clusters for CRP:

C-reactive protein, pentraxin-related

Hs.76452 [show with all ESTs], Hs.709456 [show with all ESTs]

Unigene Representative Sequences: NM_000567, BC070257

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000255030(uc001ftw.3 uc001ftx.1) ENST00000473196 ENST00000368112

ENST00000368111 ENST00000489317 ENST00000368110 ENST00000343919 ENST00000437342(uc001fty.1)

miRNA Products:		OriGene 3'-UTR Clone: CRP Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CRP
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate CRP:
		hsa-miR-637 hsa-miR-218-1*
		SwitchGear 3'UTR luciferase reporter plasmid: CRP 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CRP (see all 7) OriGene shRNA RFP: CRP OriGene siRNA: CRP
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CRP
		Sirion Biotech Custom design and validation of potent shRNA sequences against CRP

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CRP (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CRP OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript Custom all cDNA clones Services for CRP
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRP
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRP

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CRP Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CRP
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CRP
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRP

Additional cDNA sequence:

BC020766.1 BC070257.1

17 DOTS entries:

DT.448901 DT.102829615 DT.100826852 DT.100826853 DT.92446899 DT.92446914 DT.100826854 DT.92446905

DT.92446889 DT.92446887 DT.92446903 DT.92446904 DT.92446908 DT.92446913 DT.95111437 DT.95111452

DT.95111466

24/248 AceView cDNA sequences (see all 248):

AA345345 AA344442 AA344005 T78026 BG616499 T40091 AA343486 AA343870

BX283165 AA345584 BG568547 AV661354 BG618251 AW192271 AV653853 AA345182

AA343521 AV659299 AA344672 AA345587 AA344310 AA345783 T61726 AV659487

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CRP (see all 8) About this scheme

ExUns:	1	^	2a	·	2b	^	3	^	4a	·	4b	·	4c	^	5	^	6a	·	6b	·	6c	·	6d	·	6e	·	6f
SP1:							-						-
SP2:							-						-		-
SP3:							-		-				-
SP4:							-		-				-		-		-
SP5:							-		-

ECgene alternative splicing isoforms for CRP

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CRP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGAGAGACT

About this image
See CRP Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CRP

SOURCE GeneReport for Unigene clusters: Hs.76452 Hs.709456

UniProtKB/Swiss-Prot: CRP_HUMAN, P02741

Tissue specificity: Found in plasma

SABiosciences Expression via Pathway-Focused PCR Arrays including CRP (see all 8):

Inflammatory Response & Autoimmunity in human mouse rat

JAK / STAT Signaling Pathway in human mouse rat

Inflammatory Response & Autoimmunity 384HT in human mouse rat

Stress & Toxicity PathwayFinder in human mouse rat

Antibacterial Response in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CRP Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CRP
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CRP
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRP

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRP

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CRP gene from 4/13 species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CRP⁶	--	48(a)	1 → many	Un(45472063-45472647)
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 5)	--	46(a) 45(a) (see all 5)	many ↔ many many ↔ many (see all 5)	GL343640.1(53931-55784) GL344144.1(41421-44569)
African clawed frog (Xenopus laevis)	Amphibia	Xl.16219²	Xenopus laevis transcribed sequence with weak similarity more	81.38(n)		BJ035031.1
zebrafish (Danio rerio)	Actinopterygii	si:ch211-270n8.1⁶	si:ch211-270n8.1	18(a)	1 → many	13(20508374-20510467)

ENSEMBL Gene Tree for CRP (if available)
TreeFam Gene Tree for CRP (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CRP gene

NPTX2² APCS² CBX6² PTX4² NPTX1² NPTXR² PTX3²

3 SIMAP similar genes for CRP using alignment to 3 protein entries: CRP_HUMAN (see all proteins):

APCS MPTX NPTX1

CRP for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for CRP
PGOHUM00000244305

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs199953854^1,2	C	other	134492215(+)	`GCTGGG/TCAAGA`	2	T P	mis¹		0	--	--	--	--
rs3093080^1,2	C,F,H	--	131038203(-)	`TCAAGT/ATCTTT`	1	--	ds500¹		12		NS EA NA	1612
rs2808631^1,2	C,F	--	131038496(+)	`GTTAGT/CCACAA`	1	--	ds500¹		6		NS NA WA	1970
rs111626041^1,2	C	--	131038533(+)	`CTTGGT/ACTCAC`	1	--	ds500¹		1		CSA	1
rs6413467^1,2	C,F,H	--	131038702(-)	`CATGGA/TGAGAG`	1	--	ut3¹		13		MN NS EA NA WA	1116
rs17860477^1,2		--	131038745(+)	`TTCACA/GTCCTC`	1	--	ut3¹ ese³		0	--	--	--	--
rs3116640^1,2	C	--	131038774(-)	`ATCTTC/TTTGCT`	1	--	ut3¹		5		MN	404
rs3116639^1,2	C	--	131038866(-)	`CCTATC/TTGGAG`	1	--	ut3¹ ese³		5		MN	404
rs3116638^1,2	C,H	--	131038882(-)	`CCYATC/TTCCCC`	1	--	ut3¹ ese³		9		MN NS EA	812
rs6413466^1,2	C,F,H	--	131038885(-)	`YCTCCC/TATCTC`	1	--	ut3¹ ese³		11		MN NS EA NA	902

HapMap Linkage Disequilibrium report for CRP (159682079 - 159684379 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CRP: --
Human Gene Mutation Database (HGMD): CRP

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CRP

DNA2.0 Custom Variant and Variant Library Synthesis for CRP

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CRP for disorders           About GeneDecksing

OMIM gene information: 123260    OMIM disorders: --

20/456 diseases for CRP (see all 456):    About MalaCards

carotid intimal medial thickness cranial nerve palsy muckle-wells syndrome protein-energy malnutrition

alpha 1-antitrypsin deficiency rosai-dorfman disease tick-borne encephalitis human granulocytic anaplasmosis

hyper-igd syndrome glycogen storage disease type ia spinal cord injury multiple cranial nerve palsy

adult-onset still's disease suppurative otitis media polymyalgia rheumatica bronchiolitis obliterans organizing pneumonia

churg-strauss syndrome mononeuritis multiplex open-angle glaucoma hyperferritinemia-cataract syndrome

20/53 diseases from the University of Copenhagen DISEASES database for CRP (see all 53):

Heart disease Atherosclerosis Diabetes mellitus Rheumatoid arthritis

Hypertension Cerebrovascular accident Pneumonia Appendicitis

Inflammatory bowel disease Kidney failure Vasculitis Osteomyelitis

Ankylosing spondylitis Meningitis Pancreatitis Anemia

Kawasaki disease Septic arthritis Periodontal disease Chronic obstructive pulmonary disease

10/92 Novoseek disease relationships for CRP gene (see all 92) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
inflammation	92.2	2306	15496560 (5), 15550763 (4), 19272152 (4), 15472532 (4) (see all 99)
response acute phase	90	247	14634117 (3), 10353472 (3), 1699702 (3), 14743546 (3) (see all 99)
cardiovascular diseases	85.5	685	15529024 (6), 12823355 (4), 18855714 (4), 10393687 (4) (see all 99)
rheumatoid arthritis	84.5	150	16489709 (3), 8539481 (2), 17516213 (2), 20433772 (2) (see all 99)
atherosclerosis	84.4	572	12468765 (5), 17576871 (4), 11448405 (3), 16526209 (3) (see all 99)
necrosis	76.9	783	20447537 (3), 20499416 (3), 12732100 (3), 2014508 (3) (see all 99)
insulin resistance	76.2	399	15542929 (5), 19188739 (5), 15983332 (4), 19680627 (4) (see all 99)
coronary heart disease	75.6	345	19567438 (7), 12796068 (5), 18178405 (3), 16290959 (3) (see all 99)
coronary artery disease	74.5	220	19463117 (4), 11703959 (3), 9781965 (3), 12587783 (2) (see all 99)
systemic inflammatory response syndrome	73.3	41	15073705 (1), 15990980 (1), 16078967 (1), 17260130 (1) (see all 35)

Genetic Association Database (GAD): CRP
Human Genome Epidemiology (HuGE) Navigator: CRP (666 documents)

Export disorders for CRP gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CRP gene, integrated from 9 sources (see all 6218):
(articles sorted by number of sources associating them with CRP)

Utopia: connect your pdf to the dynamic
world of online information

Characterization of genomic and complementary DNA sequence of human C-reactive protein, and comparison with the complementary DNA sequence of serum amyloid P component. (PubMed id 3840479)^{1, 2, 3} Woo P.... Whitehead A.S. (1985)
Isolation of human C-reactive protein complementary DNA and localization of the gene to chromosome 1. (PubMed id 6857266)^{1, 2, 3} Whitehead A.S....Woods D.E. (1983)
Epistatic effect of C-reactive protein (CRP) single nucleotide polymorphism (SNP) +1059 and interleukin-1B SNP +3954 on CRP concentration in healthy male blood donors. (PubMed id 16026589)^{1, 4, 9} Eklund C....Hurme M. (2005)
Relation of polymorphism within the C-reactive protein gene and plasma CRP levels. (PubMed id 15585211)^{1, 4, 9} Suk H.J....Zee R.Y. (2005)
Single-nucleotide polymorphisms in the C-reactive protein (CRP) gene promoter that affect transcription factor binding, alter transcriptional activity, and associate with differences in baseline serum CRP level. (PubMed id 15778807)^{1, 4, 9} Szalai A.J....Kimberly R.P. (2005)
Association between baseline levels of C-reactive protein (CRP) and a dinucleotide repeat polymorphism in the intron of the CRP gene. (PubMed id 11857055)^{1, 4, 9} Szalai A.J....Kimberly R.P. (2002)
No association between C-reactive protein gene polymorphisms and decrease of C-reactive protein serum concentration after infliximab treatment in Crohn's disease. (PubMed id 16344720)^{1, 4, 9} Willot S....Louis E. (2006)
The physiological structure of human C-reactive protein and its complex with phosphocholine. (PubMed id 10368284)^{1, 2, 9} Thompson D.... Wood S.P. (1999)
Genetic polymorphisms and the risk of stroke after cardiac surgery. (PubMed id 16051899)^{1, 4, 9} Grocott H.P....Newman M.F. (2005)
Association of common CRP gene variants with CRP levels and cardiovascular events. (PubMed id 16266402)^{1, 4, 9} Miller D.T....Kwiatkowski D.J. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 1401	HGNC: 2367	AceView: CRP	Ensembl:ENSG00000132693	euGenes: HUgn1401
ECgene: CRP	H-InvDB: CRP

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CRP	Pharmacogenomics, SNPs, Pathways
Wikipedia	http://en.wikipedia.org/wiki/C-reactive_protein
SeattleSNPs	http://pga.gs.washington.edu/data/crp/
Protein Spotlight	http://web.expasy.org/spotlight/back_issues/sptlt030.shtml

Intellectual Property for CRP gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CRP gene:
Search GeneIP for patents involving CRP

GeneCards and IP:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section

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Spondylitis Ankylosing
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AMYLOIDOSIS SECONDARY
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