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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CRP Gene

protein-coding   GIFtS: 66
GCID: GC01M159682

C-Reactive Protein, Pentraxin-Related

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
C-Reactive Protein, Pentraxin-Related1 2
Pentraxin 11 2
PTX12 3
C-Reactive Protein2

External Ids:    HGNC: 23671   Entrez Gene: 14012   Ensembl: ENSG000001326937   OMIM: 1232605   UniProtKB: P027413   

Export aliases for CRP gene to outside databases

Previous GC identifers: GC01M157474 GC01M155414 GC01M156459 GC01M156899 GC01M156495 GC01M157948 GC01M131038


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CRP Gene:
The protein encoded by this gene belongs to the pentaxin family. It is involved in several host defense related
functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their
elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of
this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other
inflammatory stimuli. (provided by RefSeq, Sep 2009)

GeneCards Summary for CRP Gene: 
CRP (C-reactive protein, pentraxin-related) is a protein-coding gene. Diseases associated with CRP include pneumonia, and appendicitis, and among its related super-pathways are Immune response Lectin induced complement pathway and Activation of cAMP-Dependent PKA. GO annotations related to this gene include low-density lipoprotein particle binding and protein homodimerization activity. An important paralog of this gene is NPTX2.

UniProtKB/Swiss-Prot: CRP_HUMAN, P02741
Function: Displays several functions associated with host defense: it promotes agglutination, bacterial capsular
swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can
interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells

Gene Wiki entry for CRP (C-reactive protein) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CRP gene promoter:
         Max1   TBP   FOXO3   CUTL1   Nkx2-5   FOXO3b   AREB6   FOXO3a   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCRP promoter sequence
   Search SABiosciences Chromatin IP Primers for CRP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CRP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23.2   Ensembl cytogenetic band:  1q23.2   HGNC cytogenetic band: 1q23.2

CRP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRP gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M159682:  view genomic region     (about GC identifiers)

Start:
159,682,079 bp from pter      End:
159,684,379 bp from pter
Size:
2,301 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CRP_HUMAN, P02741 (See protein sequence)
Recommended Name: C-reactive protein precursor  
Size: 224 amino acids; 25039 Da
Cofactor: Binds 2 calcium ions per subunit
Subunit: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits
Subcellular location: Secreted
Mass spectrometry: Mass=23028; Method=MALDI; Range=19-224; Source=Ref.15;
Mass spectrometry: Mass=22930; Method=MALDI; Range=19-223; Source=Ref.15;
Miscellaneous: This protein owes its name to its ability precipitate pneumococcal C-polysaccharide in the presence
of calcium
6/7 PDB 3D structures from and Proteopedia for CRP (see all 7):
1B09 (3D)        1CRV (3D)        1GNH (3D)        1LJ7 (3D)        3L2Y (3D)        3PVN (3D)    
Secondary accessions: A8K078 D3DVD9 D3DVE0 Q08AK3 Q8WW75
Alternative splicing: 2 isoforms:  P02741-1   P02741-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CRP: NX_P02741

Explore proteomics data for CRP at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P02741

  • CRP Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CRP Protein Expression
    REFSEQ proteins: NP_000558.2  
    ENSEMBL proteins: 
     ENSP00000255030   ENSP00000357093   ENSP00000357092   ENSP00000357091   ENSP00000340882  
     ENSP00000402788  

    Human Recombinant Protein Products for CRP: 
    EMD Millipore Purified and/or Recombinant CRP Protein
    R&D Systems Recombinant & Natural Proteins for CRP (C-Reactive Protein/CRP)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CRP
    OriGene Protein Over-expression Lysate for CRP
    OriGene MassSpec for CRP 
    OriGene Custom Protein Services for CRP
    GenScript Custom Purified and Recombinant Proteins Services for CRP
    Novus Biologicals CRP Proteins
    Novus Biologicals CRP Lysates
    Sino Biological Recombinant Protein for CRP
    Sino Biological Cell Lysate for CRP 
    ProSpec Recombinant Protein for CRP
    Cloud-Clone Corp. Proteins for CRP 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS14718574
    GO:0005615extracellular space IEA--
    GO:0005739mitochondrion IEA--
    GO:0005886plasma membrane IEA--
    GO:0030175filopodium IEA--

    CRP for ontologies           About GeneDecksing



    CRP Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CRP
    R&D Systems Antibodies for CRP (C-Reactive Protein/CRP)
    OriGene Antibodies for CRP
    OriGene Custom Antibody Services for CRP
    GenScript Superior Antibodies for CRP
    Novus Biologicals CRP Antibodies
    Abcam antibodies for CRP
    Cloud-Clone Corp. Antibodies for CRP 
    ThermoFisher Antibody for CRP
    LSBio Antibodies in human, mouse, rat for CRP 

    Assay Products for CRP: 
    EMD Millipore Kits and Assays for the Analysis of CRP
    OriGene Custom Assay Services for CRP
    R&D Systems ELISAs for CRP (C-Reactive Protein/CRP)         (see all)
    GenScript Custom Assay Services for CRP
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CRP 
    Cloud-Clone Corp. CLIAs for CRP


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR013320 ConA-like_subgrp
     IPR001759 Pentaxin
     IPR008985 ConA-like_lec_gl_sf

    Graphical View of Domain Structure for InterPro Entry P02741

    ProtoNet protein and cluster: P02741

    1 Blocks protein domain: IPB001759 Pentaxin

    UniProtKB/Swiss-Prot: CRP_HUMAN, P02741
    Similarity: Belongs to the pentaxin family
    Similarity: Contains 1 pentaxin domain


    CRP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CRP_HUMAN, P02741
    Function: Displays several functions associated with host defense: it promotes agglutination, bacterial capsular
    swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can
    interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells
    Induction: The concentration of CRP in plasma increases greatly during acute phase response to tissue injury,
    infection or other inflammatory stimuli. It is induced by IL1/interleukin-1 and IL6//interleukin-6

         Genatlas biochemistry entry for CRP:
    C-reactive protein,acute phase reactant,pentaxin (pentraxin) family,bacterial catabolite activator protein

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17785206
    GO:0015485cholesterol binding IEA--
    GO:0030169low-density lipoprotein particle binding IDA18322245
    GO:0033265choline binding TAS2477488
    GO:0042803protein homodimerization activity IEA--
         
    CRP for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CRP:
     Synthetic lethal with c-Myc af 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Crp):
     cardiovascular system  homeostasis/metabolism  immune system 

    CRP for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Crptm1Hjf for CRP

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CRP 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CRP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CRP 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CRP 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CRP
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate CRP:
    hsa-miR-637 hsa-miR-218-1*
    SwitchGear 3'UTR luciferase reporter plasmidCRP 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CRP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CRP

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of CRP

    Clone
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    OriGene clones in human, mouse for CRP (see all 7)
    OriGene ORF clones in mouse, rat for CRP
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    GenScript Custom all cDNA clones Services for CRP
    Sino Biological Human cDNA Clone for CRP
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRP
    Sirion Biotech Customized lentivirus for stable overexpression of CRP 
                         Customized lentivirus expression plasmids for stable overexpression of CRP 

    Cell Line
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    Search LifeMap BioReagents cell lines for CRP
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRP


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CRP About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Immune response Lectin induced complement pathway
    Immune response Classic complement pathway0.53
    Immune response Classical complement pathway0.52
    2Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    PKA Signaling0.56
    3Development Leptin signaling via JAK/STAT and MAPK cascades
    Development Leptin signaling via JAK/STAT and MAPK cascades1.00
    4Development Thrombopoetin signaling via JAK-STAT pathway
    Development Thrombopoetin signaling via JAK-STAT pathway0.32
    5Selenium Pathway
    Selenium Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 EMD Millipore Pathways for CRP
        Immune response Classic complement pathway
    Development Leptin signaling via JAK/STAT and MAPK cascades
    Selected targets of HNF1
    Development Thrombopoetin signaling via JAK-STAT pathway

    4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CRP
        Activation of PKA through GPCR
    PKA Signaling
    cAMP Pathway
    Activation of cAMP-Dependent PKA

    3 GeneGo (Thomson Reuters) Pathways for CRP
        Development Leptin signaling via JAK/STAT and MAPK cascades
    Immune response Classical complement pathway
    Development Thrombopoetin signaling via JAK-STAT pathway

    2 BioSystems Pathways for CRP
        Selenium Pathway
    IL6-mediated signaling events




    CRP for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CRP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/38 Interacting proteins for CRP (P027411, 2, 3 ENSP000002550304) via UniProtKB, MINT, STRING, and/or I2D (see all 38)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FCGR2CP319951, 3EBI-1395983,EBI-1396036 I2D: score=1 
    HIST1H2AGP0C0S83, ENSP000003521194I2D: score=1 STRING: ENSP00000352119
    HIST1H2AIP0C0S83I2D: score=1 
    HIST1H2AKP0C0S83I2D: score=1 
    HIST1H2ALP0C0S83I2D: score=1 
    About this table

    Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001666response to hypoxia IEA--
    GO:0006953acute-phase response TAS2477488
    GO:0006954inflammatory response TAS10408362
    GO:0006958complement activation, classical pathway IEA--
    GO:0007568aging IEA--

    CRP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CRP for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CRP

    3 HMDB Compounds for CRP    About this table
    CompoundSynonyms CAS #PubMed Ids
    AtorvastatinAtorvastatin acid (see all 4)134523-00-5--
    CalciumCa (see all 2)7440-70-2--
    PhosphorylcholineCholine phosphate (see all 5)3616-04-4--

    1 DrugBank Compound for CRP    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Phosphocholine-- 107-73-3target--17139284 17016423

    10/134 Novoseek inferred chemical compound relationships for CRP gene (see all 134)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fibrinogen 87.4 1760 12738395 (10), 16703188 (8), 11427220 (7), 16698114 (7) (see all 99)
    cholesterol 80.1 1366 15635109 (8), 15766555 (7), 17996517 (6), 12102655 (5) (see all 99)
    homocysteine 75 478 17852421 (7), 19362308 (7), 15051846 (6), 18311078 (5) (see all 99)
    neopterin 71.9 258 18541395 (7), 1764778 (5), 15848499 (5), 19282816 (5) (see all 96)
    creatinine 69.4 495 14655192 (5), 12748357 (5), 15811980 (5), 18609082 (4) (see all 99)
    infliximab 69 89 16344720 (5), 15641046 (5), 15485995 (4), 15958758 (4) (see all 37)
    atorvastatin 68.4 151 12595863 (5), 15843280 (5), 12009719 (4), 18991814 (4) (see all 72)
    glucose 66 838 14706052 (7), 18691271 (7), 19130414 (5), 15955391 (5) (see all 99)
    aopp 65.1 65 18786315 (7), 17058827 (4), 15354943 (3), 18976759 (3) (see all 22)
    lipid 64.8 562 19621193 (6), 17356986 (5), 12542120 (5), 16775668 (5) (see all 99)

    Search CenterWatch for drugs/clinical trials and news about CRP

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CRP gene: 
    NM_000567.2  

    Unigene Clusters for CRP:

    C-reactive protein, pentraxin-related
    Hs.76452  [show with all ESTs], Hs.709456  [show with all ESTs]
    Unigene Representative Sequences: NM_000567, BC070257
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000255030(uc001ftw.3 uc001ftx.1) ENST00000473196 ENST00000368112
    ENST00000368111 ENST00000489317 ENST00000368110 ENST00000343919 ENST00000437342(uc001fty.1)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CRP
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate CRP:
    hsa-miR-637 hsa-miR-218-1*
    SwitchGear 3'UTR luciferase reporter plasmidCRP 3' UTR sequence
    Inhib. RNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRP
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                         Customized lentivirus expression plasmids for stable overexpression of CRP 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CRP
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CRP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRP

    Additional mRNA sequence: 

    BC020766.1 BC070257.1 

    17 DOTS entries:

    DT.448901  DT.102829615  DT.100826852  DT.100826853  DT.92446899  DT.92446914  DT.100826854  DT.92446905 
    DT.92446889  DT.92446887  DT.92446903  DT.92446904  DT.92446908  DT.92446913  DT.95111437  DT.95111452 
    DT.95111466 

    24/248 AceView cDNA sequences (see all 248):

    AA345345 AA345584 BG616481 AA343870 AA344005 AA345182 BG616499 AV649494 
    AA345681 BG568547 AV659487 AA345474 AV659299 AI431430 AA343669 AA343521 
    AA345587 CR598604 BE138817 AV649464 T61726 CB146596 AV653853 AA345628 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CRP (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f
    SP1:                    -                 -                                             
    SP2:                    -                 -     -                                       
    SP3:                    -     -           -                                             
    SP4:                    -     -           -     -     -                                 
    SP5:                    -     -                                                         


    ECgene alternative splicing isoforms for CRP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CRP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGAGAGACT
    CRP Expression
    About this image


    See CRP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CRP

    SOURCE GeneReport for Unigene clusters: Hs.76452 Hs.709456

    UniProtKB/Swiss-Prot: CRP_HUMAN, P02741
    Tissue specificity: Found in plasma

        SABiosciences Expression via Pathway-Focused PCR Arrays including CRP (see all 8): 
              Inflammatory Response & Autoimmunity in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat
              Antibacterial Response in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CRP gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Crp1 , 5 C-reactive protein, pentraxin-related1, 5 76.08(n)1
    70.4(a)1
      1 (80.13 cM)5
    129441  NM_007768.41  NP_031794.31 
     1726980565 
    chicken
    (Gallus gallus)
    Aves CRP6
    C-reactive protein precursor
    46(a)
    1 → many
    25(1674627-1675765)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 6)
    --
    45(a)
    45(a)
    (see all 6)
    many ↔ many
    many ↔ many
    (see all 6)
    GL344144.1(41421-44569)
    GL343640.1(33299-47988)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.162192 Xenopus laevis transcribed sequence with weak similarity more 81.38(n)    BJ035031.1 
    zebrafish
    (Danio rerio)
    Actinopterygii crp26
    crp16
    (see all 8)
    C-reactive protein 1
    (see all 8)
    34(a)
    32(a)
    (see all 8)
    possible ortholog
    possible ortholog
    (see all 8)
    24(39585485-39588797)
    24(39576237-39582275)


    ENSEMBL Gene Tree for CRP (if available)
    TreeFam Gene Tree for CRP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CRP gene
    NPTX22  APCS2  PTX42  NPTX12  NPTXR2  PTX32  
    3 SIMAP similar genes for CRP using alignment to 3 protein entries:     CRP_HUMAN (see all proteins):
    APCS    MPTX1    NPTX1

    CRP for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CRP
    PGOHUM00000244305


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/153 SNPs in CRP are shown (see all 153)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1999538541,2
    Cuntested1166179776(+) GCTGGG/TCAAGA 2 T P mis10--------
    rs585183861,2
    C--159684122(+) CAGTC-/TTTTTT 1 -- int10--------
    rs1504608661,2
    --166177229(+) CTGGAG/TGAAGC 1 -- ds50010--------
    rs30930801,2
    C,F,H--166177274(-) TCAAGT/ATCTTT 1 -- ds500112Minor allele frequency- A:0.01NS EA NA 1612
    rs28086311,2
    C,F--166177567(+) GTTAGT/CCACAA 1 -- ds50016Minor allele frequency- C:0.03NS NA WA 1970
    rs1116260411,2
    C--166177604(+) CTTGGT/ACTCAC 1 -- ds50011Minor allele frequency- A:0.00CSA 1
    rs12051,2
    C,F,O,A,H--166177764(+) CCTCAC/TAGTCT 1 -- ut31 ese335Minor allele frequency- T:0.34NA MN NS EA CSA WA 6743
    rs64134671,2
    C,F,H--166177773(-) CATGGA/TGAGAG 1 -- ut3113Minor allele frequency- T:0.01MN NS EA NA WA 1116
    rs178604771,2
    --166177816(+) TTCACA/GTCCTC 1 -- ut31 ese30--------
    rs31166401,2
    C--166177845(-) ATCTTC/TTTGCT 1 -- ut315Minor allele frequency- T:0.00MN 404

    HapMap Linkage Disequilibrium report for CRP (159682079 - 159684379 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CRP:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv825076CNV Loss20364138


    Human Gene Mutation Database (HGMD): CRP
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CRP
    DNA2.0 Custom Variant and Variant Library Synthesis for CRP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 123260    OMIM disorders: --

    20/424 diseases for CRP (see all 424):    About MalaCards
    pneumonia    appendicitis    aortitis    lymphoid interstitial pneumonia
    pulmonary aspergilloma    ulcerative proctitis    neonatal meningitis    suppurative cholangitis
    mononeuritis multiplex    chronic meningitis    suppurative otitis media    mononeuritis
    emphysematous cholecystitis    epidural abscess    pyuria    meningitis
    acute pyelonephritis    polymyalgia rheumatica    multicentric castleman disease    aspiration pneumonia

    20/58 diseases from the University of Copenhagen DISEASES database for CRP (see all 58):
    Heart disease     Atherosclerosis     Diabetes mellitus     Rheumatoid arthritis
    Hypertension     Cerebrovascular accident     Pneumonia     Appendicitis
    Crohn's disease     Kidney failure     Vasculitis     Ankylosing spondylitis
    Osteomyelitis     Meningitis     Anemia     Pancreatitis
    Septic arthritis     Kawasaki disease     Periodontal disease     Ulcerative colitis

    CRP for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/92 Novoseek inferred disease relationships for CRP gene (see all 92)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 92.2 2306 15496560 (5), 15550763 (4), 19272152 (4), 15472532 (4) (see all 99)
    response acute phase 90 247 14634117 (3), 10353472 (3), 1699702 (3), 14743546 (3) (see all 99)
    cardiovascular diseases 85.5 685 15529024 (6), 12823355 (4), 18855714 (4), 10393687 (4) (see all 99)
    rheumatoid arthritis 84.5 150 16489709 (3), 8539481 (2), 17516213 (2), 20433772 (2) (see all 99)
    atherosclerosis 84.4 572 12468765 (5), 17576871 (4), 11448405 (3), 16526209 (3) (see all 99)
    necrosis 76.9 783 20447537 (3), 20499416 (3), 12732100 (3), 2014508 (3) (see all 99)
    insulin resistance 76.2 399 15542929 (5), 19188739 (5), 15983332 (4), 19680627 (4) (see all 99)
    coronary heart disease 75.6 345 19567438 (7), 12796068 (5), 18178405 (3), 16290959 (3) (see all 99)
    coronary artery disease 74.5 220 19463117 (4), 11703959 (3), 9781965 (3), 12587783 (2) (see all 99)
    systemic inflammatory response syndrome 73.3 41 15073705 (1), 15990980 (1), 16078967 (1), 17260130 (1) (see all 35)

    Genetic Association Database (GAD): CRP
    Human Genome Epidemiology (HuGE) Navigator: CRP (666 documents)

    Export disorders for CRP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CRP gene, integrated from 9 sources (see all 6300):
    (articles sorted by number of sources associating them with CRP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of genomic and complementary DNA sequence of human C-reactive protein, and comparison with the complementary DNA sequence of serum amyloid P component. (PubMed id 3840479)1, 2, 3 Woo P.... Whitehead A.S. (1985)
    2. Isolation of human C-reactive protein complementary DNA and localization of the gene to chromosome 1. (PubMed id 6857266)1, 2, 3 Whitehead A.S....Woods D.E. (1983)
    3. Inflammation, insulin resistance, and diabetes--Mendelian randomization using CRP haplotypes points upstream. (PubMed id 18700811)1, 4, 9 Brunner E.J....Kumari M. (2008)
    4. Genetic Loci associated with C-reactive protein level s and risk of coronary heart disease. (PubMed id 19567438)1, 4, 9 Elliott P....Kooner J.S. (2009)
    5. Polymorphisms of the CRP gene inhibit inflammatory response and increase susceptibility to depression: The Health in Men Study. (PubMed id 19433520)1, 4, 9 Almeida O.P....Flicker L. (2009)
    6. The interaction of adiposity with the CRP gene affects CRP levels: age, gene/environment susceptibilty-Reykjavik study. (PubMed id 19139754)1, 4, 9 Eiriksdottir G....Gudnason V. (2009)
    7. The association of C-reactive protein and CRP genotype with coronary heart disease: findings from five studies with 4,610 cases amongst 18,637 participants. (PubMed id 18714384)1, 4, 9 Lawlor D.A....Smith G.D. (2008)
    8. Association of common C-reactive protein (CRP) gene polymorphisms with baseline plasma CRP levels and fenofibrate response: the GOLDN study. (PubMed id 18285551)1, 4, 9 Shen J....Ordovas J.M. (2008)
    9. Association between C-reactive protein gene haplotypes and C-reactive protein levels in Taiwanese: Interaction with obesity. (PubMed id 19101671)1, 4, 9 Teng M.S....Ko Y.L. (2008)
    10. Epistatic effect of C-reactive protein (CRP) single nucleotide polymorphism (SNP) +1059 and interleukin-1B SNP +3954 on CRP concentration in healthy male blood donors. (PubMed id 16026589)1, 4, 9 Eklund C....Hurme M. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1401 HGNC: 2367 AceView: CRP Ensembl:ENSG00000132693 euGenes: HUgn1401
    ECgene: CRP H-InvDB: CRP

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CRP Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/C-reactive_protein
    SeattleSNPshttp://pga.gs.washington.edu/data/crp/
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/sptlt030.shtml

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CRP gene:
    Search GeneIP for patents involving CRP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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