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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CROT Gene

protein-coding   GIFtS: 61
GCID: GC07P086974

carnitine O-octanoyltransferase
 Explore 2 diseases affiliated with
CROT via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CROT    

Aliases
for CROT gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Carnitine O-Octanoyltransferase1 2
COT1 2 3 5
EC 2.3.1.1373 8
Peroxisomal Carnitine Acyltransferase2
Peroxisomal Carnitine O-Octanoyltransferase2
EC 2.3.18

External Ids:    HGNC: 23661   Entrez Gene: 546772   Ensembl: ENSG000000054697   OMIM: 6060905   UniProtKB: Q9UKG93   

Export aliases for CROT gene to outside databases

Previous GC identifers: GC07P085510 GC07P086573 GC07P086587 GC07P086619 GC07P086812 GC07P081585


Summaries
for CROT gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CROT:
This gene encodes a member of the carnitine/choline acetyltransferase family. The encoded protein converts
4,8-dimethylnonanoyl-CoA to its corresponding carnitine ester. This transesterification occurs in the peroxisome and
is necessary for transport of medium- and long- chain acyl-CoA molecules out of the peroxisome to the cytosol and
mitochondria. The protein thus plays a role in lipid metabolism and fatty acid beta-oxidation. Alternatively spliced
transcript variants have been described.(provided by RefSeq, Jan 2009)

UniProtKB/Swiss-Prot: OCTC_HUMAN, Q9UKG9
Function: Beta-oxidation of fatty acids. The highest activity concerns the C6 to C10 chain length substrate. Converts
the end product of pristanic acid beta oxidation, 4,8-dimethylnonanoyl-CoA, to its corresponding carnitine ester

Gene Wiki entry for CROT


Genomic Views
for CROT gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007933.15  NT_079595.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CROT gene promoter:
         Oct-B1   HFH-3   Sox5   oct-B3   oct-B2   FOXI1   POU2F1   POU2F1a   POU2F1b   POU2F1c   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CROT promoter sequence
   Search SABiosciences Chromatin IP Primers for CROT

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CROT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21.1   Ensembl cytogenetic band:  7q21.12   HGNC cytogenetic band: 7q21.1

CROT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CROT gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P086974:  view genomic region     (about GC identifiers)

Start:
 86,974,951 bp from pter      End:
 87,029,112 bp from pter
Size:
 54,162 bases      Orientation:
 plus strand

1 alternative location:
Chr7+,CRA_TCAG 86,306,455-86,360,622     

Proteins
for CROT gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: OCTC_HUMAN, Q9UKG9 (See protein sequence)
Recommended Name: Peroxisomal carnitine O-octanoyltransferase  
Size: 612 amino acids; 70178 Da
Subunit: Monomer (Probable)
Subcellular location: Peroxisome (Potential)
Secondary accessions: A4D1D6 Q86V17 Q8IUW9 Q9Y6I2
Alternative splicing: 2 isoforms:  Q9UKG9-1   Q9UKG9-2   

Explore the universe of human proteins at neXtProt for CROT: NX_Q9UKG9

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UKG9

    • 4/11 DME Specific Peptides for CROT (Q9UKG9) (see all 11)
     DRHLLGL  ETDAEKLV  PGITRDSI  FYHGRTET 

    CROT Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001137407.1  NP_001230674.1  NP_066974.2  

    ENSEMBL proteins: 
     ENSP00000413575   ENSP00000404867   ENSP00000331981   ENSP00000411983  
    Reactome Protein details: Q9UKG9
    Human Recombinant Protein Products: 
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    Novus Biologicals CROT Proteins
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    Uscn Proteins for CROT

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005625soluble fraction ----
    GO:0005739mitochondrion ----
    GO:0005777peroxisome NAS10486279
    GO:0005782peroxisomal matrix TAS--
    GO:0043231intracellular membrane-bounded organelle IDA--


    CROT for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for CROT

    Protein Domains /
    Families
    for CROT gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CROT for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR000542 Carn_acyl_trans

    Graphical View of Domain Structure for InterPro Entry Q9UKG9

    ProtoNet protein and cluster: Q9UKG9

    1 Blocks protein family: IPB000542 Acyltransferase ChoActase/COT/CPT

    UniProtKB/Swiss-Prot: OCTC_HUMAN, Q9UKG9
    Similarity: Belongs to the carnitine/choline acetyltransferase family


    Function
    for CROT gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: OCTC_HUMAN, Q9UKG9
    Function: Beta-oxidation of fatty acids. The highest activity concerns the C6 to C10 chain length substrate. Converts
    the end product of pristanic acid beta oxidation, 4,8-dimethylnonanoyl-CoA, to its corresponding carnitine ester
    Catalytic activity: Octanoyl-CoA + L-carnitine = CoA + L-octanoylcarnitine

    Enzyme Numbers (IUBMB): EC 2.3.1.1371 2 EC 2.3.12

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CROT
    8/37 QIAGEN miScript miRNA Assays for microRNAs that regulate CROT (see all 37):
    hsa-miR-140-5p hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-106a hsa-miR-1304 hsa-miR-372 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmid: CROT 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CROT (see all 7)
    OriGene shRNA RFP: CROT
    OriGene siRNA: CROT
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CROT

    Gene Editing
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CROT (see all 4)
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    GenScript: all cDNA clones in your preferred vector (see all 2): CROT (NM_021151)
    Sino Biological Human cDNA Clone for CROT
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CROT 

    Cell Line
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    Search LifeMap BioReagents cell lines for CROT

    In Situ Assay
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding IPI--
    GO:0008458carnitine O-octanoyltransferase activity IDA10486279
    GO:0016746transferase activity, transferring acyl groups ----


    CROT for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for CROT:
     Decreased viability 


    Pathways & Interactions
    for CROT gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Metabolism
    		Metabolism1.00
    		Metabolism of lipids and lipoproteins0.34
    2Peroxisomal lipid metabolism
    		Peroxisomal lipid metabolism1.00
    		Beta-oxidation of pristanoyl-CoA0.40
    3Peroxisome
    		Peroxisome1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    4        Reactome Pathways for CROT
        Beta-oxidation of pristanoyl-CoA
    Metabolism
    Peroxisomal lipid metabolism
    Metabolism of lipids and lipoproteins


    1         Kegg Pathway  (Kegg details for CROT):
        Peroxisome

    UniProtKB/Swiss-Prot: OCTC_HUMAN, Q9UKG9
    Pathway: Lipid metabolism; fatty acid beta-oxidation


    CROT for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CROT

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for CROT (Q9UKG93 ENSP000004135754) via UniProtKB, MINT, STRING, and/or I2D

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ALBP027683, ENSP000002958974I2D: score=1 STRING: ENSP00000295897
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006091generation of precursor metabolites and energy IDA10486279
    GO:0006631fatty acid metabolic process IMP--
    GO:0006635fatty acid beta-oxidation IDA--
    GO:0006810transport IEA--
    GO:0010243response to organic nitrogen ----


    CROT for ontologies           About GeneDecksing



    Drugs & Compounds
    for CROT gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CROT for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CROT

    10/11 HMDB Compounds for CROT (see all 11)    About this table
    CompoundSynonyms CAS #PubMed Ids
    4,8-Dimethylnonanoyl-CoAS-(4,8-dimethylnonanoate)-Coenzyme A (see all 6)204120-61-69469587
    4,8 dimethylnonanoyl carnitine4,8-dimethylnonanoylcarnitine ----
    Capric acid1-Nonanecarboxylate (see all 25)334-48-5--
    Caproic acid1-Hexanoate (see all 26)142-62-1--
    Caprylic acid1-Heptanecarboxylate (see all 21)124-07-2--
    Ceramide (d18:1/20:0)(2S,3R,4E)-2-acylamino-1,3-octadec-4-enediol (see all 6)104404-17-3--
    Coenzyme AAcetoacetyl coenzyme A sodium salt (see all 21)85-61-0--
    Dodecanoic acid1-Undecanecarboxylate (see all 28)143-07-7--
    L-Carnitine(-)-(R)-3-Hydroxy-4-(trimethylammonio)butyrate (see all 33)541-15-1--
    L-OctanoylcarnitineOctanoic acid ester with L-(3-carboxy-2-hydroxypropyl)trimethylammonium hydroxide inner salt (see all 9)25243-95-2--

    3 DrugBank Compounds for CROT    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (3-Carboxy-2-(R)-Hydroxy-Propyl)-Trimethyl-Ammonium-- 461-06-3target--17139284 17016423 10592235
    3-Carboxy-N,N,N-Trimethyl-2-(Octanoyloxy)Propan-1-Aminium-- --target--17139284 17016423 10592235
    L-Carnitine(-)-Carnitine (see all 6)541-15-1target--16681386 15155769

    5 Novoseek chemical compound relationships for CROT gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carnitine 84.9 41 1822803 (4), 1530596 (2), 9480926 (2), 11912554 (2) (see all 13)
    acyl-coa 72.1 2 17956234 (1), 11790793 (1)
    acetyl-coa 60.8 3 1822803 (2), 17956234 (1)
    fatty acid 44.3 4 10486279 (1), 1530596 (1)
    histidine 33.3 1 9480926 (1)

    Search CenterWatch for drugs/clinical trials and news about CROT / OCTC 

    Transcripts
    for CROT gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CROT gene (3 alternative transcripts): 
    NM_001143935.1  NM_001243745.1  NM_021151.3  

    Unigene Cluster for CROT:

    Carnitine O-octanoyltransferase
    Hs.125039  [show with all ESTs]
    Unigene Representative Sequence: NM_001143935
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000419147 ENST00000412227(uc003uis.3) ENST00000331536(uc003uiu.3 uc003uit.3)
    ENST00000442291 ENST00000488850 ENST00000469785 ENST00000479014

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CROT
    8/37 QIAGEN miScript miRNA Assays for microRNAs that regulate CROT (see all 37):
    hsa-miR-140-5p hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-106a hsa-miR-1304 hsa-miR-372 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmid: CROT 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CROT (see all 7)
    OriGene shRNA RFP: CROT
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CROT
    Clone
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    Primer
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    Additional cDNA sequence: 

    AF052187.1 AF073770.1 AF168793.1 AK127901.1 AK300114.1 AK313487.1 BC006015.2 BC012483.1 
    BC019226.1 BC039004.1 BC051874.1 

    7 DOTS entries:

    DT.447942  DT.100814137  DT.100814138  DT.102824602  DT.40262869  DT.100698628  DT.121046789 

    24/131 AceView cDNA sequences (see all 131):

    BU752329 AI948441 BE855620 H54688 AA552928 AF052187 F09045 NM_021151 
    AA603735 N30301 BF814938 BX364971 CK904851 BM834728 F11380 BC006015 
    BF814937 AF073770 CD678372 BX364972 BX091220 AI628267 BM055197 AA744558 

    GeneLoc Exon Structure


    Expression
    for CROT gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CROT expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGTGCCTGTA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See CROT Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CROT

    SOURCE GeneReport for Unigene cluster: Hs.125039
        SABiosciences Expression via Pathway-Focused PCR Arrays including CROT: 
              Fatty Acid Metabolism in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CROT

    Orthologs
    for CROT gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for CROT gene from 6/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CROT1 carnitine O-octanoyltransferase 69.83(n)
    67.16(a)    		   420533  XM_003640663.1  XP_003640711.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CROT6
    		 --
    		 67(a)
    		 1 ↔ 1
    		 6(19262708-19283828)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.159142 Xenopus laevis transcribed sequence with weak similarity to protein spQ9UKG9 (H.sapiens) OCTC_HUMAN Peroxisomal carnitine octanoyltransferase (COT) less 79.53(n)    BJ044291.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii crot1 carnitine O-octanoyltransferase 63.18(n)
    61.44(a)    		   553204  NM_001018151.1  NP_001018161.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG124281 , 3 carnitine O-octanoyltransferase3
    CG124281    		 31(a)3
    42.46(n)1
    32.41(a)1    		   98B23
    433321  NM_143326.31  NP_651583.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea T20B3.13
    F41E7.61    		 Carnitate acyltransferase3
    Protein F41E7.61    		 32(a)
    (best of 2)3
    45.05(n)1
    34.75(a)1    		   V(16818168-16823163)3
    1856241  NM_077328.11  NP_509729.11 


    ENSEMBL Gene Tree for CROT (if available)
    TreeFam Gene Tree for CROT (if available) 

    Paralogs
    for CROT gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CROT gene
    CPT1C2  CRAT2  CPT1B2  CPT1A2  CHAT2  
    4 SIMAP similar genes for CROT using alignment to 3 protein entries:     OCTC_HUMAN (see all proteins):
    CRAT    ChAT    CPT1A    CHAT

    CROT for paralogs           About GeneDecksing



    Genomic Variants
    for CROT gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/944 NCBI SNPs in CROT are shown (see all 944)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1815707401,2
    		--86976810(+) CAGATC/TTACAT 3 -- int10--------
    rs1176008031,2
    		C,F,--86976989(+) CAAAAT/CACAAT 3 -- int11Minor allele frequency- C:0.02NA 120
    rs1863373091,2
    		--86977194(+) CATGAC/GCTGGA 3 -- int10--------
    rs1415184871,2
    		--86977312(+) CAGAGA/GAAAAC 3 -- int10--------
    rs1470310941,2
    		--86977325(+) GTATTA/GGCTGA 3 -- int10--------
    rs1477029611,2
    		--86977368(+) GTGTTC/TGATTC 3 -- int10--------
    rs1899460441,2
    		--86977381(+) TAACCC/TATGAG 3 -- int10--------
    rs1822520511,2
    		--86977383(+) ACCTAA/TGAGTG 3 -- int10--------
    rs8129631,2
    		H--86977406(+) TAGCGT/GTGCTA 3 -- int18Minor allele frequency- G:0.00NS EA NA 474
    rs69433911,2
    		C,F,A,--86977425(+) AAAAAA/GTAGTT 3 -- int12Minor allele frequency- G:0.11WA NA 238

    HapMap Linkage Disequilibrium report for CROT (86974951 - 87029112 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CROT: --

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    Disorders / Diseases
    for CROT gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CROT for disorders           About GeneDecksing

    OMIM gene information: 606090    OMIM disorders: --

    2 diseases for CROT:    About MalaCards
    refsum disease    alzheimer's disease

    Human Genome Epidemiology (HuGE) Navigator: CROT (2 documents)

    Export disorders for CROT gene to outside databases

    Publications
    for CROT gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CROT gene, integrated from 9 sources (see all 33):
    (articles sorted by number of sources associating them with CROT)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and expression of human carnitine octanoyltransferase: evidence for its role in the peroxisomal beta- oxidation of branched-chain fatty acids. (PubMed id 10486279)1, 2, 3, 9 Ferdinandusse S.... Wanders R.J.A. (1999)
    2. Structural model of a malonyl-CoA-binding site of carnitine octanoyltransferase and carnitine palmitoyltransferase I: mutational analysis of a malonyl-CoA affinity domain. (PubMed id 11790793)1, 2, 9 Morillas M.... Asins G. (2002)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
    5. Genomics of the human carnitine acyltransferase genes. (PubMed id 11001805)1, 9 van der Leij F.R....Bartelds B. (2000)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. Changes in carnitine octanoyltransferase activity ind uce alteration in fatty acid metabolism. (PubMed id 21619872)1 Le Borgne F....Demarquoy J. (2011)
    8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    9. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
    10. In vitro selection of adenine-dependent ribozyme against Tpl2/Cot oncogene. (PubMed id 19054068)1 Li Y.L....Maurel M.C. (2009)

    External Searches for CROT gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CROT gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54677 HGNC: 2366 AceView: CROT Ensembl:ENSG00000005469 euGenes: HUgn54677
    ECgene: CROT Kegg: 54677 H-InvDB: CROT

    Other Databases showing CROT gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CROT gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CROT Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CROT gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CROT gene:
    Search GeneIP for patents involving CROT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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