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CROT Gene

protein-coding   GIFtS: 63
GCID: GC07P086974

Carnitine O-Octanoyltransferase

  Search for CROT
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Carnitine O-Octanoyltransferase1 2
COT2 3 5
EC 2.3.1.1373 8
Peroxisomal Carnitine Acyltransferase2
Peroxisomal Carnitine O-Octanoyltransferase2
EC 2.3.18

External Ids:    HGNC: 23661   Entrez Gene: 546772   Ensembl: ENSG000000054697   OMIM: 6060905   UniProtKB: Q9UKG93   

Export aliases for CROT gene to outside databases

Previous GC identifers: GC07P085510 GC07P086573 GC07P086587 GC07P086619 GC07P086812 GC07P081585


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CROT Gene:
This gene encodes a member of the carnitine/choline acetyltransferase family. The encoded protein converts
4,8-dimethylnonanoyl-CoA to its corresponding carnitine ester. This transesterification occurs in the peroxisome
and is necessary for transport of medium- and long- chain acyl-CoA molecules out of the peroxisome to the cytosol
and mitochondria. The protein thus plays a role in lipid metabolism and fatty acid beta-oxidation. Alternatively
spliced transcript variants have been described.(provided by RefSeq, Jan 2009)

GeneCards Summary for CROT Gene:
CROT (carnitine O-octanoyltransferase) is a protein-coding gene. GO annotations related to this gene include carnitine O-octanoyltransferase activity and receptor binding. An important paralog of this gene is CPT1C.

UniProtKB/Swiss-Prot: OCTC_HUMAN, Q9UKG9
Function: Beta-oxidation of fatty acids. The highest activity concerns the C6 to C10 chain length substrate.
Converts the end product of pristanic acid beta oxidation, 4,8-dimethylnonanoyl-CoA, to its corresponding
carnitine ester

Gene Wiki entry for CROT Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CROT gene promoter:
         Oct-B1   HFH-3   Sox5   oct-B3   oct-B2   FOXI1   POU2F1   POU2F1a   POU2F1b   POU2F1c   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CROT promoter sequence
   Search Chromatin IP Primers for CROT

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CROT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21.1   Ensembl cytogenetic band:  7q21.12   HGNC cytogenetic band: 7q21.1

CROT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CROT gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P086974:  view genomic region     (about GC identifiers)

Start:
86,974,951 bp from pter      End:
87,029,112 bp from pter
Size:
54,162 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 86,306,455-86,360,622     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: OCTC_HUMAN, Q9UKG9 (See protein sequence)
Recommended Name: Peroxisomal carnitine O-octanoyltransferase  
Size: 612 amino acids; 70178 Da
Subunit: Monomer (Probable)
Secondary accessions: A4D1D6 E7EQF2 Q86V17 Q8IUW9 Q9Y6I2
Alternative splicing: 3 isoforms:  Q9UKG9-1   Q9UKG9-2   Q9UKG9-3   (No experimental confirmation available. Gene prediction based on cDNA data)

Explore the universe of human proteins at neXtProt for CROT: NX_Q9UKG9

Explore proteomics data for CROT at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CROT (Q9UKG9) (see all 11)
     DRHLLGL  ETDAEKLV  PGITRDSI  FYHGRTET 


    See CROT Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001137407.1  NP_001230674.1  NP_066974.2  

    ENSEMBL proteins: 
     ENSP00000413575   ENSP00000404867   ENSP00000331981   ENSP00000411983  
    Reactome Protein details: Q9UKG9

    CROT Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Novus Biologicals CROT Proteins
    Novus Biologicals CROT Lysates
    Sino Biological Recombinant Protein for CROT
    Sino Biological Cell Lysate for CROT
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for CROT 

    CROT Antibody Products:

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    LSBio Antibodies in human, mouse, rat for CROT

    CROT Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for CROT 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR000542 Carn_acyl_trans

    Graphical View of Domain Structure for InterPro Entry Q9UKG9

    ProtoNet protein and cluster: Q9UKG9

    1 Blocks protein domain: IPB000542 Acyltransferase ChoActase/COT/CPT

    UniProtKB/Swiss-Prot: OCTC_HUMAN, Q9UKG9
    Similarity: Belongs to the carnitine/choline acetyltransferase family


    Find genes that share domains with CROT           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OCTC_HUMAN, Q9UKG9
    Function: Beta-oxidation of fatty acids. The highest activity concerns the C6 to C10 chain length substrate.
    Converts the end product of pristanic acid beta oxidation, 4,8-dimethylnonanoyl-CoA, to its corresponding
    carnitine ester
    Catalytic activity: Octanoyl-CoA + L-carnitine = CoA + L-octanoylcarnitine

         Enzyme Numbers (IUBMB): EC 2.3.1.1371 2 EC 2.3.12

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding IPI--
    GO:0008458carnitine O-octanoyltransferase activity IDA10486279
    GO:0016746transferase activity, transferring acyl groups ----
         
    Find genes that share ontologies with CROT           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CROT:
     Decreased viability 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CROT
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CROT

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CROT
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CROT

    miRNA
    Products:
        
    miRTarBase miRNAs that target CROT:
    hsa-mir-106b-5p (MIRT020476), hsa-mir-221-3p (MIRT046842), hsa-mir-33a-5p (MIRT007354)

    Block miRNA regulation of human, mouse, rat CROT using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CROT (see all 37):
    hsa-miR-140-5p hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-106a hsa-miR-1304 hsa-miR-372 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidCROT 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CROT
    Predesigned siRNA for gene silencing in human, mouse, rat CROT

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CROT

    Clone
    Products:
         
    OriGene clones in human, mouse for CROT (see all 12)
    OriGene ORF clones in mouse, rat for CROT
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CROT (NM_021151)
    Sino Biological Human cDNA Clone for CROT
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CROT
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CROT

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for CROT
    Browse ESI BIO Cell Lines and PureStem Progenitors for CROT 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CROT


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OCTC_HUMAN, Q9UKG9: Peroxisome (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    peroxisome4
    cytosol3
    nucleus2
    mitochondrion1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--
    GO:0005777peroxisome NAS10486279
    GO:0005782peroxisomal matrix TAS--
    GO:0043231intracellular membrane-bounded organelle IDA--

    Find genes that share ontologies with CROT           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CROT About    
    See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    2Peroxisomal lipid metabolism
    Peroxisomal lipid metabolism
    Beta-oxidation of pristanoyl-CoA0.00
    3Peroxisome
    Peroxisome


    Find genes that share SuperPaths with CROT           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for CROT
        Beta-oxidation of pristanoyl-CoA


    1 Kegg Pathway  (Kegg details for CROT):
        Peroxisome

    UniProtKB/Swiss-Prot: OCTC_HUMAN, Q9UKG9
    Pathway: Lipid metabolism; fatty acid beta-oxidation

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CROT: 

              Fatty Acid Metabolism in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CROT

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for CROT (Q9UKG93 ENSP000004135754) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ALBP027683, ENSP000002958974I2D: score=1 STRING: ENSP00000295897
    NDUFA7ENSP000003014574STRING: ENSP00000301457
    BCKDHAENSP000002699804STRING: ENSP00000269980
    PDHA1ENSP000003943824STRING: ENSP00000394382
    PDHA2ENSP000002952664STRING: ENSP00000295266
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006091generation of precursor metabolites and energy IDA10486279
    GO:0006631fatty acid metabolic process IMP--
    GO:0006635fatty acid beta-oxidation IDA--
    GO:0009437carnitine metabolic process ISS--
    GO:0015908fatty acid transport IEA--

    Find genes that share ontologies with CROT           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CROT (OCTC)

    Selected HMDB Compounds for CROT (see all 11)    About this table
    CompoundSynonyms CAS #PubMed Ids
    4,8-Dimethylnonanoyl-CoAS-(4,8-dimethylnonanoate)-Coenzyme A (see all 6)204120-61-69469587
    4,8 dimethylnonanoyl carnitine4,8-dimethylnonanoylcarnitine ----
    Capric acid1-Nonanecarboxylate (see all 25)334-48-5--
    Caproic acid1-Hexanoate (see all 26)142-62-1--
    Caprylic acid1-Heptanecarboxylate (see all 21)124-07-2--
    Ceramide (d18:1/20:0)(2S,3R,4E)-2-acylamino-1,3-octadec-4-enediol (see all 6)104404-17-3--
    Coenzyme AAcetoacetyl coenzyme A sodium salt (see all 21)85-61-0--
    Dodecanoic acid1-Undecanecarboxylate (see all 28)143-07-7--
    L-Carnitine(-)-(R)-3-Hydroxy-4-(trimethylammonio)butyrate (see all 33)541-15-1--
    L-OctanoylcarnitineOctanoic acid ester with L-(3-carboxy-2-hydroxypropyl)trimethylammonium hydroxide inner salt (see all 9)25243-95-2--

    3 DrugBank Compounds for CROT    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (3-Carboxy-2-(R)-Hydroxy-Propyl)-Trimethyl-Ammonium-- 461-06-3target--17139284 17016423 10592235
    3-Carboxy-N,N,N-Trimethyl-2-(Octanoyloxy)Propan-1-Aminium-- --target--17139284 17016423 10592235
    L-Carnitine(-)-Carnitine (see all 6)541-15-1target--16681386 15155769

    5 Novoseek inferred chemical compound relationships for CROT gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carnitine 84.9 41 1822803 (4), 1530596 (2), 9480926 (2), 11912554 (2) (see all 13)
    acyl-coa 72.1 2 17956234 (1), 11790793 (1)
    acetyl-coa 60.8 3 1822803 (2), 17956234 (1)
    fatty acid 44.3 4 10486279 (1), 1530596 (1)
    histidine 33.3 1 9480926 (1)



    Find genes that share compounds with CROT           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CROT gene (3 alternative transcripts): 
    NM_001143935.1  NM_001243745.1  NM_021151.3  

    Unigene Cluster for CROT:

    Carnitine O-octanoyltransferase
    Hs.125039  [show with all ESTs]
    Unigene Representative Sequence: NM_001143935
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000419147 ENST00000412227(uc003uis.3) ENST00000331536(uc003uiu.3 uc003uit.3)
    ENST00000442291 ENST00000488850 ENST00000469785 ENST00000479014
    miRNA
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    Block miRNA regulation of human, mouse, rat CROT using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CROT (see all 37):
    hsa-miR-140-5p hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-106a hsa-miR-1304 hsa-miR-372 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidCROT 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Predesigned siRNA for gene silencing in human, mouse, rat CROT
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): CROT (NM_021151)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CROT
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CROT
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CROT
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CROT
      QuantiTect SYBR Green Assays in human, mouse, rat CROT
      QuantiFast Probe-based Assays in human, mouse, rat CROT

    Additional mRNA sequence: 

    AF052187.1 AF073770.1 AF168793.1 AK127901.1 AK300114.1 AK313487.1 BC006015.2 BC012483.1 
    BC019226.1 BC039004.1 BC051874.1 

    7 DOTS entries:

    DT.447942  DT.100814137  DT.100814138  DT.102824602  DT.40262869  DT.100698628  DT.121046789 

    Selected AceView cDNA sequences (see all 131):

    BC019226 R99301 BC039004 F11380 BC012483 AI628267 BX364972 BF814938 
    BF814937 BX091220 AA603735 H54688 F09045 CK904851 BM055197 CD678372 
    BE855620 N30301 BQ719543 AI948441 BM834728 BC006015 AA552928 BU752329 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CROT expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTGCCTGTA
    CROT Expression
    About this image


    CROT expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    CROT Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CROT Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.125039
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CROT: 
              Fatty Acid Metabolism in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CROT
    OriGene qSTAR qPCR primer pairs in human, mouse for CROT
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CROT
    QuantiTect SYBR Green Assays in human, mouse, rat CROT
    QuantiFast Probe-based Assays in human, mouse, rat CROT
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CROT

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CROT gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Crot1 , 5 carnitine O-octanoyltransferase1, 5 85.29(n)1
    85.62(a)1
      5 (3.50 cM)5
    741141  NM_023733.31  NP_076222.11 
     89660335 
    chicken
    (Gallus gallus)
    Aves CROT1 carnitine O-octanoyltransferase 69.83(n)
    67.16(a)
      420533  XM_418635.4  XP_418635.2 
    lizard
    (Anolis carolinensis)
    Reptilia CROT6
    carnitine O-octanoyltransferase
    67(a)
    1 ↔ 1
    6(19239269-19283903)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.159142 Xenopus laevis transcribed sequence with weak similarity more 79.53(n)    BJ044291.1 
    zebrafish
    (Danio rerio)
    Actinopterygii crot1 carnitine O-octanoyltransferase 63.18(n)
    61.44(a)
      553204  NM_001018151.1  NP_001018161.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG124281 , 3 carnitine O-octanoyltransferase3
    CG124281
    31(a)3
    42.79(n)1
    32.7(a)1
      98B23
    433321  NM_143326.31  NP_651583.11 
    worm
    (Caenorhabditis elegans)
    Secernentea T20B3.13
    CELE_T20B3.11
    Carnitate acyltransferase3
    CELE_T20B3.11
    32(a)
    (best of 2)3
    45.18(n)1
    35(a)1
      V(16818168-16823163)3
    1801261  NM_074844.31  NP_507245.11 


    ENSEMBL Gene Tree for CROT (if available)
    TreeFam Gene Tree for CROT (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CROT gene
    CPT1C2  CRAT2  CPT1B2  CPT1A2  CHAT2  
    4 SIMAP similar genes for CROT using alignment to 2 protein entries:     OCTC_HUMAN (see all proteins):
    ChAT    CRAT    CHAT    CPT1A

    Find genes that share paralogs with CROT           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CROT (see all 1098)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1815707401,2
    --86976810(+) CAGATC/TTACAT 3 -- int10--------
    rs1176008031,2
    C,F--86976989(+) CAAAAT/CACAAT 3 -- int11Minor allele frequency- C:0.02NA 120
    rs1863373091,2
    --86977194(+) CATGAC/GCTGGA 3 -- int10--------
    rs1415184871,2
    --86977312(+) CAGAGA/GAAAAC 3 -- int10--------
    rs1470310941,2
    --86977325(+) GTATTA/GGCTGA 3 -- int10--------
    rs1477029611,2
    --86977368(+) GTGTTC/TGATTC 3 -- int10--------
    rs1899460441,2
    --86977381(+) TAACCC/TATGAG 3 -- int10--------
    rs1822520511,2
    --86977383(+) ACCTAA/TGAGTG 3 -- int10--------
    rs8129631,2
    H--86977406(+) TAGCGT/GTGCTA 3 -- int18Minor allele frequency- G:0.00NS EA NA 474
    rs69433911,2
    C,F,A--86977425(+) AAAAAA/GTAGTT 3 -- int12Minor allele frequency- G:0.11WA NA 238

    HapMap Linkage Disequilibrium report for CROT (86974951 - 87029112 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for CROT:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv270404CNV Insertion20981092
    nsv366901CNV Insertion16902084
    esv992601CNV Insertion20482838
    nsv888678CNV Loss21882294
    nsv428177CNV Loss18775914
    nsv464622CNV Gain19166990
    nsv888677CNV Gain21882294
    esv259427OTHER Complex20981092
    esv259930OTHER Complex20981092

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CROT
    DNA2.0 Custom Variant and Variant Library Synthesis for CROT

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606090    OMIM disorders: --


    Find genes that share disorders with CROT           About GenesLikeMe

    Genetic Association Database (GAD): CROT
    Human Genome Epidemiology (HuGE) Navigator: CROT (2 documents)

    Export disorders for CROT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CROT gene, integrated from 10 sources (see all 37):
    (articles sorted by number of sources associating them with CROT)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and expression of human carnitine octanoyltransferase: evidence for its role in the peroxisomal beta- oxidation of branched-chain fatty acids. (PubMed id 10486279)1, 2, 3, 9 Ferdinandusse S.... Wanders R.J.A. (Biochem. Biophys. Res. Commun. 1999)
    2. Structural model of a malonyl-CoA-binding site of carnitine octanoyltransferase and carnitine palmitoyltransferase I: mutational analysis of a malonyl-CoA affinity domain. (PubMed id 11790793)1, 2, 9 Morillas M.... Asins G. (J. Biol. Chem. 2002)
    3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (Science 2003)
    7. Genomics of the human carnitine acyltransferase genes. (PubMed id 11001805)1, 9 van der Leij F.R....Bartelds B. (Mol. Genet. Metab. 2000)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    9. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    10. Changes in carnitine octanoyltransferase activity induce alteration in fatty acid metabolism. (PubMed id 21619872)1 Le Borgne F....Demarquoy J. (Biochem. Biophys. Res. Commun. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54677 HGNC: 2366 AceView: CROT Ensembl:ENSG00000005469 euGenes: HUgn54677
    ECgene: CROT Kegg: 54677 H-InvDB: CROT

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CROT Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CROT gene:
    Search GeneIP for patents involving CROT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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