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Aliases for CROT Gene

Aliases for CROT Gene

  • Carnitine O-Octanoyltransferase 2 3
  • COT 3 4 6
  • EC 4 64
  • Peroxisomal Carnitine O-Octanoyltransferase 3
  • Peroxisomal Carnitine Acyltransferase 3
  • EC 2.3.1 64

External Ids for CROT Gene

Summaries for CROT Gene

Entrez Gene Summary for CROT Gene

  • This gene encodes a member of the carnitine/choline acetyltransferase family. The encoded protein converts 4,8-dimethylnonanoyl-CoA to its corresponding carnitine ester. This transesterification occurs in the peroxisome and is necessary for transport of medium- and long- chain acyl-CoA molecules out of the peroxisome to the cytosol and mitochondria. The protein thus plays a role in lipid metabolism and fatty acid beta-oxidation. Alternatively spliced transcript variants have been described.[provided by RefSeq, Jan 2009]

GeneCards Summary for CROT Gene

CROT (Carnitine O-Octanoyltransferase) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include receptor binding and carnitine O-octanoyltransferase activity. An important paralog of this gene is CRAT.

UniProtKB/Swiss-Prot for CROT Gene

  • Beta-oxidation of fatty acids. The highest activity concerns the C6 to C10 chain length substrate. Converts the end product of pristanic acid beta oxidation, 4,8-dimethylnonanoyl-CoA, to its corresponding carnitine ester.

Gene Wiki entry for CROT Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CROT Gene

Genomics for CROT Gene

Genomic Location for CROT Gene

87,345,635 bp from pter
87,399,796 bp from pter
54,162 bases
Plus strand

Genomic View for CROT Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CROT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CROT Gene

Regulatory Elements for CROT Gene

Proteins for CROT Gene

  • Protein details for CROT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Peroxisomal carnitine O-octanoyltransferase
    Protein Accession:
    Secondary Accessions:
    • A4D1D6
    • E7EQF2
    • Q86V17
    • Q8IUW9
    • Q9Y6I2

    Protein attributes for CROT Gene

    612 amino acids
    Molecular mass:
    70178 Da
    Quaternary structure:
    • Monomer.

    Alternative splice isoforms for CROT Gene


neXtProt entry for CROT Gene

Proteomics data for CROT Gene at MOPED

Post-translational modifications for CROT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CROT Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for CROT Gene

Protein Domains for CROT Gene


  • Belongs to the carnitine/choline acetyltransferase family.:
    • Q9UKG9
genes like me logo Genes that share domains with CROT: view

No data available for Gene Families for CROT Gene

Function for CROT Gene

Molecular function for CROT Gene

UniProtKB/Swiss-Prot CatalyticActivity: Octanoyl-CoA + L-carnitine = CoA + L-octanoylcarnitine
UniProtKB/Swiss-Prot Function: Beta-oxidation of fatty acids. The highest activity concerns the C6 to C10 chain length substrate. Converts the end product of pristanic acid beta oxidation, 4,8-dimethylnonanoyl-CoA, to its corresponding carnitine ester.

Enzyme Numbers (IUBMB) for CROT Gene

Gene Ontology (GO) - Molecular Function for CROT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IPI 20178365
GO:0008458 carnitine O-octanoyltransferase activity IDA 10486279
GO:0016746 transferase activity, transferring acyl groups --
genes like me logo Genes that share ontologies with CROT: view

Phenotypes for CROT Gene

GenomeRNAi human phenotypes for CROT:
genes like me logo Genes that share phenotypes with CROT: view

miRNA for CROT Gene

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for CROT Gene

Localization for CROT Gene

Subcellular locations from UniProtKB/Swiss-Prot for CROT Gene


Subcellular locations from

Jensen Localization Image for CROT Gene COMPARTMENTS Subcellular localization image for CROT gene
Compartment Confidence
peroxisome 4
cytosol 3
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CROT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005777 peroxisome NAS 10486279
GO:0005782 peroxisomal matrix TAS --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with CROT: view

Pathways for CROT Gene

genes like me logo Genes that share pathways with CROT: view

Pathways by source for CROT Gene

UniProtKB/Swiss-Prot Q9UKG9-OCTC_HUMAN

  • Pathway: Lipid metabolism; fatty acid beta-oxidation

Interacting Proteins for CROT Gene

Gene Ontology (GO) - Biological Process for CROT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006091 generation of precursor metabolites and energy IDA 10486279
GO:0006631 fatty acid metabolic process IMP 21619872
GO:0006635 fatty acid beta-oxidation IDA 21619872
GO:0008152 metabolic process --
GO:0009437 carnitine metabolic process ISS --
genes like me logo Genes that share ontologies with CROT: view

Compounds for CROT Gene

(11) HMDB Compounds for CROT Gene

Compound Synonyms Cas Number PubMed IDs
4,8 dimethylnonanoyl carnitine
  • 4,8-dimethylnonanoylcarnitine
Not Available
  • S-(4,8-dimethylnonanoate)-Coenzyme A
Capric acid
  • 1-Nonanecarboxylate
Caproic acid
  • 1-Hexanoate
Caprylic acid
  • 1-Heptanecarboxylate

(3) Drugbank Compounds for CROT Gene

(5) Novoseek inferred chemical compound relationships for CROT Gene

Compound -log(P) Hits PubMed IDs
carnitine 84.9 19
acyl-coa 72.1 2
acetyl-coa 60.8 3
fatty acid 44.3 2
histidine 33.3 1
genes like me logo Genes that share compounds with CROT: view

Transcripts for CROT Gene

Unigene Clusters for CROT Gene

Carnitine O-octanoyltransferase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CROT Gene

No ASD Table

Relevant External Links for CROT Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CROT Gene

mRNA expression in normal human tissues for CROT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CROT Gene

SOURCE GeneReport for Unigene cluster for CROT Gene Hs.125039

genes like me logo Genes that share expressions with CROT: view

Orthologs for CROT Gene

This gene was present in the common ancestor of animals.

Orthologs for CROT Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CROT 36
  • 99.74 (n)
  • 99.69 (a)
  • 100 (a)
(Bos Taurus)
Mammalia CROT 36
  • 87.47 (n)
  • 84.8 (a)
  • 83 (a)
(Canis familiaris)
Mammalia CROT 36
  • 87.8 (n)
  • 84.64 (a)
  • 84 (a)
(Mus musculus)
Mammalia Crot 36
  • 85.29 (n)
  • 85.62 (a)
Crot 16
Crot 37
  • 86 (a)
(Monodelphis domestica)
Mammalia CROT 37
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia CROT 37
  • 74 (a)
(Rattus norvegicus)
Mammalia Crot 36
  • 83.66 (n)
  • 84.8 (a)
(Gallus gallus)
Aves CROT 36
  • 69.83 (n)
  • 67.16 (a)
  • 67 (a)
(Anolis carolinensis)
Reptilia CROT 37
  • 67 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15914 36
tropical clawed frog
(Silurana tropicalis)
Amphibia crot 36
  • 67.58 (n)
  • 65.89 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7341 36
(Danio rerio)
Actinopterygii crot 36
  • 63.18 (n)
  • 61.44 (a)
crot 37
  • 62 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002329 36
  • 45.43 (n)
  • 36.13 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12428 36
  • 42.79 (n)
  • 32.7 (a)
CG12428 37
  • 32 (a)
CG12428 38
  • 31 (a)
(Caenorhabditis elegans)
Secernentea CELE_T20B3.1 36
  • 45.18 (n)
  • 35 (a)
F41E7.6 37
  • 31 (a)
T20B3.1 37
  • 31 (a)
F41E7.6 38
  • 31 (a)
T20B3.1 38
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 44 (a)
Species with no ortholog for CROT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CROT Gene

Gene Tree for CROT (if available)
Gene Tree for CROT (if available)

Paralogs for CROT Gene

Paralogs for CROT Gene

Selected SIMAP similar genes for CROT Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CROT: view

Variants for CROT Gene

Sequence variations from dbSNP and Humsavar for CROT Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs10639 -- 87,399,585(-) CACCA(A/C)AATGA utr-variant-3-prime
rs31627 -- 87,380,888(+) AATGG(A/G)TTTGT intron-variant
rs31628 -- 87,381,370(+) CCTAT(C/T)TTTCC intron-variant
rs31629 -- 87,381,572(+) TCTTC(A/G)TGTTG intron-variant
rs31630 -- 87,382,033(+) TAATA(A/G)TTCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CROT Gene

Variant ID Type Subtype PubMed ID
nsv888677 CNV Gain 21882294
nsv464622 CNV Gain 19166990
nsv428177 CNV Loss 18775914
nsv888678 CNV Loss 21882294
esv270404 CNV Insertion 20981092
esv259427 OTHER Complex 20981092
esv259930 OTHER Complex 20981092
esv992601 CNV Insertion 20482838
nsv366901 CNV Insertion 16902084

Relevant External Links for CROT Gene

HapMap Linkage Disequilibrium report

Disorders for CROT Gene

Relevant External Links for CROT

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CROT: view

No data available for UniProtKB/Swiss-Prot for CROT Gene

Publications for CROT Gene

  1. Molecular cloning and expression of human carnitine octanoyltransferase: evidence for its role in the peroxisomal beta- oxidation of branched-chain fatty acids. (PMID: 10486279) Ferdinandusse S. … Wanders R.J.A. (Biochem. Biophys. Res. Commun. 1999) 2 3 4 23
  2. Structural model of a malonyl-CoA-binding site of carnitine octanoyltransferase and carnitine palmitoyltransferase I: mutational analysis of a malonyl-CoA affinity domain. (PMID: 11790793) Morillas M. … Asins G. (J. Biol. Chem. 2002) 3 4 23
  3. Genomics of the human carnitine acyltransferase genes. (PMID: 11001805) van der Leij F.R. … Bartelds B. (Mol. Genet. Metab. 2000) 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49

Products for CROT Gene

Sources for CROT Gene

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