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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CROT Gene

protein-coding   GIFtS: 63
GCID: GC07P086974

Carnitine O-Octanoyltransferase

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Carnitine O-Octanoyltransferase1 2
COT2 3 5
EC 2.3.1.1373 8
Peroxisomal Carnitine Acyltransferase2
Peroxisomal Carnitine O-Octanoyltransferase2
EC 2.3.18

External Ids:    HGNC: 23661   Entrez Gene: 546772   Ensembl: ENSG000000054697   OMIM: 6060905   UniProtKB: Q9UKG93   

Export aliases for CROT gene to outside databases

Previous GC identifers: GC07P085510 GC07P086573 GC07P086587 GC07P086619 GC07P086812 GC07P081585


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CROT Gene:
This gene encodes a member of the carnitine/choline acetyltransferase family. The encoded protein converts
4,8-dimethylnonanoyl-CoA to its corresponding carnitine ester. This transesterification occurs in the peroxisome
and is necessary for transport of medium- and long- chain acyl-CoA molecules out of the peroxisome to the cytosol
and mitochondria. The protein thus plays a role in lipid metabolism and fatty acid beta-oxidation. Alternatively
spliced transcript variants have been described.(provided by RefSeq, Jan 2009)

GeneCards Summary for CROT Gene: 
CROT (carnitine O-octanoyltransferase) is a protein-coding gene. Diseases associated with CROT include refsum disease, and alzheimer's disease, and among its related super-pathways are Metabolic pathways and Beta-oxidation of pristanoyl-CoA. GO annotations related to this gene include carnitine O-octanoyltransferase activity and receptor binding. An important paralog of this gene is CPT1C.

UniProtKB/Swiss-Prot: OCTC_HUMAN, Q9UKG9
Function: Beta-oxidation of fatty acids. The highest activity concerns the C6 to C10 chain length substrate.
Converts the end product of pristanic acid beta oxidation, 4,8-dimethylnonanoyl-CoA, to its corresponding
carnitine ester

Gene Wiki entry for CROT Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007933.15  NT_079595.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CROT gene promoter:
         Oct-B1   HFH-3   Sox5   oct-B3   oct-B2   FOXI1   POU2F1   POU2F1a   POU2F1b   POU2F1c   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CROT promoter sequence
   Search SABiosciences Chromatin IP Primers for CROT

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CROT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21.1   Ensembl cytogenetic band:  7q21.12   HGNC cytogenetic band: 7q21.1

CROT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CROT gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P086974:  view genomic region     (about GC identifiers)

Start:
86,974,951 bp from pter      End:
87,029,112 bp from pter
Size:
54,162 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 86,306,455-86,360,622     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: OCTC_HUMAN, Q9UKG9 (See protein sequence)
Recommended Name: Peroxisomal carnitine O-octanoyltransferase  
Size: 612 amino acids; 70178 Da
Subunit: Monomer (Probable)
Subcellular location: Peroxisome (Potential)
Secondary accessions: A4D1D6 E7EQF2 Q86V17 Q8IUW9 Q9Y6I2
Alternative splicing: 3 isoforms:  Q9UKG9-1   Q9UKG9-2   Q9UKG9-3   (No experimental confirmation available. Gene prediction based on cDNA data)

Explore the universe of human proteins at neXtProt for CROT: NX_Q9UKG9

Explore proteomics data for CROT at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UKG9

  • 4/11 DME Specific Peptides for CROT (Q9UKG9) (see all 11)
     DRHLLGL  ETDAEKLV  PGITRDSI  FYHGRTET 

    CROT Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CROT Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001137407.1  NP_001230674.1  NP_066974.2  

    ENSEMBL proteins: 
     ENSP00000413575   ENSP00000404867   ENSP00000331981   ENSP00000411983  
    Reactome Protein details: Q9UKG9
    Human Recombinant Protein Products for CROT: 
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    Sino Biological Cell Lysate for CROT 
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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--
    GO:0005777peroxisome NAS10486279
    GO:0005782peroxisomal matrix TAS--
    GO:0043231intracellular membrane-bounded organelle IDA--

    CROT for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR000542 Carn_acyl_trans

    Graphical View of Domain Structure for InterPro Entry Q9UKG9

    ProtoNet protein and cluster: Q9UKG9

    1 Blocks protein domain: IPB000542 Acyltransferase ChoActase/COT/CPT

    UniProtKB/Swiss-Prot: OCTC_HUMAN, Q9UKG9
    Similarity: Belongs to the carnitine/choline acetyltransferase family


    CROT for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OCTC_HUMAN, Q9UKG9
    Function: Beta-oxidation of fatty acids. The highest activity concerns the C6 to C10 chain length substrate.
    Converts the end product of pristanic acid beta oxidation, 4,8-dimethylnonanoyl-CoA, to its corresponding
    carnitine ester
    Catalytic activity: Octanoyl-CoA + L-carnitine = CoA + L-octanoylcarnitine

         Enzyme Numbers (IUBMB): EC 2.3.1.1371 2 EC 2.3.12

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding IPI--
    GO:0008458carnitine O-octanoyltransferase activity IDA10486279
    GO:0016746transferase activity, transferring acyl groups ----
         
    CROT for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CROT:
     Decreased viability 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CROT 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CROT

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CROT 
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    miRNA
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    hsa-miR-140-5p hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-106a hsa-miR-1304 hsa-miR-372 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidCROT 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CROT About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34
    2Peroxisomal lipid metabolism
    Beta-oxidation of pristanoyl-CoA0.38
    Peroxisomal lipid metabolism0.38
    3Peroxisome
    Peroxisome

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    4        Reactome Pathways for CROT
        Beta-oxidation of pristanoyl-CoA
    Metabolism
    Peroxisomal lipid metabolism
    Metabolism of lipids and lipoproteins


    1         Kegg Pathway  (Kegg details for CROT):
        Peroxisome

    UniProtKB/Swiss-Prot: OCTC_HUMAN, Q9UKG9
    Pathway: Lipid metabolism; fatty acid beta-oxidation


    CROT for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CROT

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for CROT (Q9UKG93 ENSP000004135754) via UniProtKB, MINT, STRING, and/or I2D

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ALBP027683, ENSP000002958974I2D: score=1 STRING: ENSP00000295897
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006091generation of precursor metabolites and energy IDA10486279
    GO:0006631fatty acid metabolic process IMP--
    GO:0006635fatty acid beta-oxidation IDA--
    GO:0006810transport ----
    GO:0015908fatty acid transport IEA--

    CROT for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CROT for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CROT (OCTC)

    10/11 HMDB Compounds for CROT (see all 11)    About this table
    CompoundSynonyms CAS #PubMed Ids
    4,8-Dimethylnonanoyl-CoAS-(4,8-dimethylnonanoate)-Coenzyme A (see all 6)204120-61-69469587
    4,8 dimethylnonanoyl carnitine4,8-dimethylnonanoylcarnitine ----
    Capric acid1-Nonanecarboxylate (see all 25)334-48-5--
    Caproic acid1-Hexanoate (see all 26)142-62-1--
    Caprylic acid1-Heptanecarboxylate (see all 21)124-07-2--
    Ceramide (d18:1/20:0)(2S,3R,4E)-2-acylamino-1,3-octadec-4-enediol (see all 6)104404-17-3--
    Coenzyme AAcetoacetyl coenzyme A sodium salt (see all 21)85-61-0--
    Dodecanoic acid1-Undecanecarboxylate (see all 28)143-07-7--
    L-Carnitine(-)-(R)-3-Hydroxy-4-(trimethylammonio)butyrate (see all 33)541-15-1--
    L-OctanoylcarnitineOctanoic acid ester with L-(3-carboxy-2-hydroxypropyl)trimethylammonium hydroxide inner salt (see all 9)25243-95-2--

    3 DrugBank Compounds for CROT    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (3-Carboxy-2-(R)-Hydroxy-Propyl)-Trimethyl-Ammonium-- 461-06-3target--17139284 17016423 10592235
    3-Carboxy-N,N,N-Trimethyl-2-(Octanoyloxy)Propan-1-Aminium-- --target--17139284 17016423 10592235
    L-Carnitine(-)-Carnitine (see all 6)541-15-1target--16681386 15155769

    5 Novoseek inferred chemical compound relationships for CROT gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carnitine 84.9 41 1822803 (4), 1530596 (2), 9480926 (2), 11912554 (2) (see all 13)
    acyl-coa 72.1 2 17956234 (1), 11790793 (1)
    acetyl-coa 60.8 3 1822803 (2), 17956234 (1)
    fatty acid 44.3 4 10486279 (1), 1530596 (1)
    histidine 33.3 1 9480926 (1)

    Search CenterWatch for drugs/clinical trials and news about CROT / OCTC

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CROT gene (3 alternative transcripts): 
    NM_001143935.1  NM_001243745.1  NM_021151.3  

    Unigene Cluster for CROT:

    Carnitine O-octanoyltransferase
    Hs.125039  [show with all ESTs]
    Unigene Representative Sequence: NM_001143935
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000419147 ENST00000412227(uc003uis.3) ENST00000331536(uc003uiu.3 uc003uit.3)
    ENST00000442291 ENST00000488850 ENST00000469785 ENST00000479014

    miRNA
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    8/37 QIAGEN miScript miRNA Assays for microRNAs that regulate CROT (see all 37):
    hsa-miR-140-5p hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-106a hsa-miR-1304 hsa-miR-372 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidCROT 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AF052187.1 AF073770.1 AF168793.1 AK127901.1 AK300114.1 AK313487.1 BC006015.2 BC012483.1 
    BC019226.1 BC039004.1 BC051874.1 

    7 DOTS entries:

    DT.447942  DT.100814137  DT.100814138  DT.102824602  DT.40262869  DT.100698628  DT.121046789 

    24/131 AceView cDNA sequences (see all 131):

    AI948441 BC006015 CD678308 AI628267 H54688 BF814938 BX364971 AA603735 
    BC012483 BM693369 CD678372 NM_021151 AA744558 F09045 BM055197 BC039004 
    BC051874 R99301 CK904851 BU752329 AF073770 AA552928 F11380 BF814937 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CROT expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTGCCTGTA
    CROT Expression
    About this image


    See CROT Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CROT

    SOURCE GeneReport for Unigene cluster: Hs.125039
        SABiosciences Expression via Pathway-Focused PCR Arrays including CROT: 
              Fatty Acid Metabolism in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CROT

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CROT gene from 8/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Crot1 , 5 carnitine O-octanoyltransferase1, 5 85.29(n)1
    85.62(a)1
      5 (3.50 cM)5
    741141  NM_023733.31  NP_076222.11 
     89660335 
    chicken
    (Gallus gallus)
    Aves CROT1 carnitine O-octanoyltransferase 69.83(n)
    67.16(a)
      420533  XM_003640663.1  XP_003640711.1 
    lizard
    (Anolis carolinensis)
    Reptilia CROT6
    carnitine O-octanoyltransferase
    67(a)
    1 ↔ 1
    6(19239269-19283903)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.159142 Xenopus laevis transcribed sequence with weak similarity more 79.53(n)    BJ044291.1 
    zebrafish
    (Danio rerio)
    Actinopterygii crot1 carnitine O-octanoyltransferase 63.18(n)
    61.44(a)
      553204  NM_001018151.1  NP_001018161.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG124281 , 3 carnitine O-octanoyltransferase3
    CG124281
    31(a)3
    42.46(n)1
    32.41(a)1
      98B23
    433321  NM_143326.31  NP_651583.11 
    worm
    (Caenorhabditis elegans)
    Secernentea T20B3.13
    F41E7.61
    Carnitate acyltransferase3
    Protein F41E7.61
    32(a)
    (best of 2)3
    45.05(n)1
    34.75(a)1
      V(16818168-16823163)3
    1856241  NM_077328.11  NP_509729.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CAT26
    Carnitine acetyl-CoA transferase present in both m...
    21(a)
    1 → many
    XIII(192788-194800)


    ENSEMBL Gene Tree for CROT (if available)
    TreeFam Gene Tree for CROT (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CROT gene
    CPT1C2  CRAT2  CPT1B2  CPT1A2  CHAT2  
    4 SIMAP similar genes for CROT using alignment to 2 protein entries:     OCTC_HUMAN (see all proteins):
    ChAT    CRAT    CHAT    CPT1A

    CROT for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1098 SNPs in CROT are shown (see all 1098)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1815707401,2
    --86976810(+) CAGATC/TTACAT 3 -- int10--------
    rs1176008031,2
    C,F--86976989(+) CAAAAT/CACAAT 3 -- int11Minor allele frequency- C:0.02NA 120
    rs1863373091,2
    --86977194(+) CATGAC/GCTGGA 3 -- int10--------
    rs1415184871,2
    --86977312(+) CAGAGA/GAAAAC 3 -- int10--------
    rs1470310941,2
    --86977325(+) GTATTA/GGCTGA 3 -- int10--------
    rs1477029611,2
    --86977368(+) GTGTTC/TGATTC 3 -- int10--------
    rs1899460441,2
    --86977381(+) TAACCC/TATGAG 3 -- int10--------
    rs1822520511,2
    --86977383(+) ACCTAA/TGAGTG 3 -- int10--------
    rs8129631,2
    H--86977406(+) TAGCGT/GTGCTA 3 -- int18Minor allele frequency- G:0.00NS EA NA 474
    rs69433911,2
    C,F,A--86977425(+) AAAAAA/GTAGTT 3 -- int12Minor allele frequency- G:0.11WA NA 238

    HapMap Linkage Disequilibrium report for CROT (86974951 - 87029112 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for CROT:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv270404CNV Insertion20981092
    nsv366901CNV Insertion16902084
    esv992601CNV Insertion20482838
    nsv888678CNV Loss21882294
    nsv428177CNV Loss18775914
    nsv464622CNV Gain19166990
    nsv888677CNV Gain21882294
    esv259427OTHER Complex20981092
    esv259930OTHER Complex20981092

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606090    OMIM disorders: --

    2 diseases for CROT:    About MalaCards
    refsum disease    alzheimer's disease


    CROT for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): CROT
    Human Genome Epidemiology (HuGE) Navigator: CROT (2 documents)

    Export disorders for CROT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CROT gene, integrated from 9 sources (see all 36):
    (articles sorted by number of sources associating them with CROT)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and expression of human carnitine octanoyltransferase: evidence for its role in the peroxisomal beta- oxidation of branched-chain fatty acids. (PubMed id 10486279)1, 2, 3, 9 Ferdinandusse S.... Wanders R.J.A. (1999)
    2. Structural model of a malonyl-CoA-binding site of carnitine octanoyltransferase and carnitine palmitoyltransferase I: mutational analysis of a malonyl-CoA affinity domain. (PubMed id 11790793)1, 2, 9 Morillas M.... Asins G. (2002)
    3. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
    7. Genomics of the human carnitine acyltransferase genes. (PubMed id 11001805)1, 9 van der Leij F.R....Bartelds B. (2000)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. Changes in carnitine octanoyltransferase activity ind uce alteration in fatty acid metabolism. (PubMed id 21619872)1 Le Borgne F....Demarquoy J. (2011)
    10. A proteome-wide perspective on peroxisome targeting s ignal 1(PTS1)-Pex5p affinities. (PubMed id 20178365)1 Ghosh D. and Berg J.M. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54677 HGNC: 2366 AceView: CROT Ensembl:ENSG00000005469 euGenes: HUgn54677
    ECgene: CROT Kegg: 54677 H-InvDB: CROT

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CROT Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CROT gene:
    Search GeneIP for patents involving CROT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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