Aliases for CROT Gene
External Ids for CROT Gene
Previous GeneCards Identifiers for CROT Gene
This gene encodes a member of the carnitine/choline acetyltransferase family. The encoded protein converts 4,8-dimethylnonanoyl-CoA to its corresponding carnitine ester. This transesterification occurs in the peroxisome and is necessary for transport of medium- and long- chain acyl-CoA molecules out of the peroxisome to the cytosol and mitochondria. The protein thus plays a role in lipid metabolism and fatty acid beta-oxidation. Alternatively spliced transcript variants have been described.[provided by RefSeq, Jan 2009]
GeneCards Summary for CROT Gene
CROT (Carnitine O-Octanoyltransferase) is a Protein Coding gene. Diseases associated with CROT include Refsum Disease. Among its related pathways are Metabolism and Peroxisome. GO annotations related to this gene include receptor binding and carnitine O-octanoyltransferase activity. An important paralog of this gene is CRAT.
UniProtKB/Swiss-Prot for CROT Gene
Beta-oxidation of fatty acids. The highest activity concerns the C6 to C10 chain length substrate. Converts the end product of pristanic acid beta oxidation, 4,8-dimethylnonanoyl-CoA, to its corresponding carnitine ester.