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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CROCC Gene

protein-coding GIFtS: 47
GCID: GC01P017093

Ciliary Rootlet Coiled-Coil, Rootletin

See related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Ciliary Rootlet Coiled-Coil, Rootletin¹ ²		ROLT²
rootletin¹ ²		Rootletin, Ciliary Rootlet Protein²
Ciliary Rootlet Coiled-Coil Protein² ³		Tax1-Binding Protein 2²
Ciliary Rootlet Protein¹		KIAA0445³

External Ids:	HGNC: 21299¹	Entrez Gene: 9696²	Ensembl: ENSG00000058453⁷	UniProtKB: Q5TZA2³

Export aliases for CROCC gene to outside databases

Previous GC identifers: GC01P016201 GC01P016631 GC01P016993 GC01P017121 GC01P017049 GC01P017223 GC01P015492

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CROCC Gene:

CROCC (ciliary rootlet coiled-coil, rootletin) is a protein-coding gene. Diseases associated with CROCC include large cell medulloblastoma, and childhood medulloblastoma. GO annotations related to this gene include structural molecule activity and kinesin binding. An important paralog of this gene is LOC728763.

UniProtKB/Swiss-Prot: CROCC_HUMAN, Q5TZA2

Function: Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which

originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus.

Contributes to centrosome cohesion before mitosis

Gene Wiki entry for CROCC Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.2 NT_004610.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CROCC gene promoter:
NF-1 NF-1/L p300 Pax-2 AP-4 Pax-2a AREB6 E2F-1 E2F ZID
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CROCC promoter sequence

Search SABiosciences Chromatin IP Primers for CROCC

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CROCC

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.13 Ensembl cytogenetic band: 1p36.13 HGNC cytogenetic band: 1p36.13

CROCC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CROCC gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P017093: view genomic region (about GC identifiers)

Start:	17,066,768 bp from pter	End:	17,299,474 bp from pter
Size:	232,707 bases	Orientation:	plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CROCC_HUMAN, Q5TZA2 (See protein sequence)

Recommended Name: Rootletin

Size: 2017 amino acids; 228523 Da

Subunit: Homopolymer. Interacts with KLC3, NEK2 and the N-terminus of CEP250

Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=In

ciliated cells, associated with ciliary rootlets. In non-ciliated cells, localized between, around and at the

proximal ends of the centrioles. Dissociates from the centrioles at the onset of mitosis and reassociates with

them at anaphase

Secondary accessions: Q2VHY3 Q66GT7 Q7Z2L4 Q7Z5D7

Alternative splicing: 2 isoforms: Q5TZA2-1 Q5TZA2-2

Explore the universe of human proteins at neXtProt for CROCC: NX_Q5TZA2

Explore proteomics data for CROCC at MOPED

Post-translational modifications:

UniProtKB: Phosphorylated by NEK2 which may regulate its association with centrosomes

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q5TZA2

CROCC Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_055490.3

ENSEMBL proteins:

ENSP00000364691 ENSP00000402626

Human Recombinant Protein Products for CROCC:

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	Browse ProSpec Recombinant Proteins
	Browse Proteins at Cloud-Clone Corp.

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	--
GO:0005813	centrosome	IDA	--
GO:0005814	centriole	ISS	--
GO:0005886	plasma membrane	IDA	--
GO:0015629	actin cytoskeleton	IDA	--

CROCC for ontologies About GeneDecksing

CROCC Antibody Products:

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	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

1 InterPro protein domain:

IPR026733 Rootletin

Graphical View of Domain Structure for InterPro Entry Q5TZA2

ProtoNet protein and cluster: Q5TZA2

UniProtKB/Swiss-Prot: CROCC_HUMAN, Q5TZA2

Similarity: Belongs to the rootletin family

CROCC for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CROCC_HUMAN, Q5TZA2

Function: Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which

originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus.

Contributes to centrosome cohesion before mitosis

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005198	structural molecule activity	ISS	--
GO:0005515	protein binding	IPI	18086858
GO:0019894	kinesin binding	ISS	--

CROCC for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for CROCC:

Decreased BPV1 E2 protein expr

Increased HPV18 LCR reporter a

4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Crocc):

immune system

nervous system

respiratory system

vision/eye

CROCC for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-out Crocc^tm1Tili for CROCC

inGenious Targeting Laboratory - Custom generated mouse model solutions for CROCC

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CROCC

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CROCC

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CROCC

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CROCC
		8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate CROCC (see all 9):
		hsa-miR-3163 hsa-miR-520d-5p hsa-miR-4306 hsa-miR-548m hsa-miR-185 hsa-miR-3613-3p hsa-miR-3143 hsa-miR-524-5p

		SwitchGear 3'UTR luciferase reporter plasmid: CROCC 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for CROCC
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector: CROCC (NM_014675)
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CROCC

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CROCC

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

4 Interacting proteins for CROCC (Q5TZA2³ ENSP00000364691⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MYC	P01106³, ENSP00000367207⁴	I2D: score=1 STRING: ENSP00000367207
KLC3	Q6P597³, ENSP00000375810⁴	I2D: score=1 STRING: ENSP00000375810
MAPK1	P28482³	I2D: score=1
RNF152	ENSP00000316628⁴	STRING: ENSP00000316628

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007049	cell cycle	IEA	--
GO:0008104	protein localization	IMP	18086858
GO:0016192	vesicle-mediated transport	--	--
GO:0030030	cell projection organization	IEA	--
GO:0051297	centrosome organization	IDA	16203858

CROCC for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CROCC

Search CenterWatch for drugs/clinical trials and news about CROCC

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CROCC gene:

NM_014675.3

Unigene Cluster for CROCC:

Ciliary rootlet coiled-coil, rootletin

Hs.309403 [show with all ESTs]

Unigene Representative Sequence: NM_014675

13 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000466256(uc009voy.1) ENST00000375541(uc009voz.1 uc001azt.2 uc001azu.2 uc001azv.2)

ENST00000445545 ENST00000467938 ENST00000492631 ENST00000467715 ENST00000494191

ENST00000486318 ENST00000498688 ENST00000477773 ENST00000497654 ENST00000465021

ENST00000465291

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CROCC
		8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate CROCC (see all 9):
		hsa-miR-3163 hsa-miR-520d-5p hsa-miR-4306 hsa-miR-548m hsa-miR-185 hsa-miR-3613-3p hsa-miR-3143 hsa-miR-524-5p

		SwitchGear 3'UTR luciferase reporter plasmid: CROCC 3' UTR sequence

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Additional mRNA sequence:

AB007914.2 AF527734.1 AK026910.1 BC126911.1 BC126912.1 DQ139275.1

11 DOTS entries:

DT.95266566 DT.100743912 DT.100020214 DT.100839518 DT.449429 DT.97840379 DT.121461770 DT.40261591

DT.121346580 DT.40297433 DT.92066234

24/72 AceView cDNA sequences (see all 72):

BM725894 AA328651 BE531043 BM689120 BQ073078 NM_014675 AB007914 CR599665

CA414341 AI969545 CB306675 BV166904 BU631113 AW295613 BQ575557 BM460873

BX354187 BM549828 BQ432416 AA359769 BM678006 BQ003345 AA622336 BM763603

GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for CROCC (see all 13) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11a	·	11b	^	12	^	13	^	14a	·	14b	·	14c	^	15	^	16	^	17a	·	17b	·	17c	^	18a	·	18b	^	19	^	20a	·
SP1:
SP2:
SP3:
SP4:
SP5:

ExUns:	20b	^	21a	·	21b	^	22a	·	22b	^	23a	·	23b	^	24a	·	24b	^	25	^	26a	·	26b	·	26c	^	27a	·	27b	·	27c	·	27d
SP1:									-												-				-
SP2:									-
SP3:
SP4:
SP5:							-		-		-		-								-		-		-

ECgene alternative splicing isoforms for CROCC

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CROCC expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TGTCGGGAAA

About this image

See CROCC Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CROCC

SOURCE GeneReport for Unigene cluster: Hs.309403

SABiosciences Custom PCR Arrays for CROCC

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CROCC

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for CROCC gene from 7/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Crocc^{1 , 5}	ciliary rootlet coiled-coil, rootletin^{1, 5}	83.45(n)¹ 83.05(a)¹		4 (73.31 cM)⁵ 230872¹ NM_172122.2¹ NP_742120.2¹ 141016637⁵
chicken (Gallus gallus)	Aves	CROCC⁶	ciliary rootlet coiled-coil, rootletin	46(a)	1 ↔ 1	21(4392909-4410627)
lizard (Anolis carolinensis)	Reptilia	-- --	Uncharacterized protein	55(a) 49(a)	1 ↔ many 1 ↔ many	AAWZ02039191(901-9112) GL344546.1(3245-29436)
tropical clawed frog (Xenopus tropicalis)	Amphibia	137720735²	--	76.35(n)		137720735
zebrafish (Danio rerio)	Actinopterygii	CABZ01094378.1⁶	Uncharacterized protein	24(a)	1 ↔ 1	22(78-4766)
fruit fly (Drosophila melanogaster)	Insecta	CG6129¹	CG6129	45.08(n) 29.01(a)		42860 NM_142959.4 NP_651216.2
worm (Caenorhabditis elegans)	Secernentea	dyf-14¹	Protein DYF-14	37.83(n) 25.23(a)		173801 NM_062419.4 NP_494820.3

ENSEMBL Gene Tree for CROCC (if available)
TreeFam Gene Tree for CROCC (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CROCC gene

LOC728763² CEP250²

4 SIMAP similar genes for CROCC using alignment to 4 protein entries: CROCC_HUMAN (see all proteins):

CROCCP3 CROCCP2 CEP250 LOC728763

CROCC for paralogs About GeneDecksing

5 Pseudogenes.org Pseudogenes for CROCC
PGOHUM00000243914 PGOHUM00000243917 PGOHUM00000244623 PGOHUM00000244631 PGOHUM00000242031

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs6662700^1,2	C,F,A	--	17246540(+)	`tgccaC/Tcacgc`	1	--	us2k¹		5		NA WA CSA	10
rs35331284^1,2	C	--	17246588(+)	`ATTTT-/TGAGAC`	1	--	us2k¹		2		NA CSA	4
rs186018504^1,2		--	17246614(+)	`GTGTCA/GCCAGG`	1	--	us2k¹		0	--	--	--	--
rs6662820^1,2	C,H	--	17246644(+)	`tctcgG/Cctcac`	1	--	us2k¹		8		NA WA CSA	16
rs189034323^1,2		--	17246666(+)	`CCTCCC/TAGGTT`	1	--	us2k¹		0	--	--	--	--
rs181379330^1,2		--	17246678(+)	`AAGCGA/TTTCTC`	1	--	us2k¹		0	--	--	--	--
rs185308295^1,2		--	17246715(+)	`ACTACA/GGGTGT`	1	--	us2k¹		0	--	--	--	--
rs150990252^1,2		--	17246934(+)	`CTGCCC/TGCCTC`	1	--	us2k¹		0	--	--	--	--
rs190663357^1,2		--	17246972(+)	`CTTGAA/GCCACT`	1	--	us2k¹		0	--	--	--	--
rs182880144^1,2	C	--	17247160(+)	`AGCCTC/TCTTGC`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CROCC (17066768 - 17299474 bp)

Structural Variations
Database of Genomic Variants (DGV) 10/39 variations for CROCC (see all 39): About this table

Variant ID	Type	Subtype	PubMed ID
nsv471438	CNV	Duplication	19718026
nsv821037	CNV	Duplication	20802225
esv2421455	CNV	Duplication	20811451
nsv508947	CNV	Insertion	20534489
nsv433184	CNV	Loss	18776910
nsv834269	CNV	Loss	17160897
dgv184n71	CNV	Loss	21882294
esv29988	CNV	Loss	17803354
dgv183n71	CNV	Loss	21882294
nsv834258	CNV	Loss	17160897

SABiosciences Cancer Mutation PCR Assays

SeqTarget long-range PCR primers for resequencing CROCC

DNA2.0 Custom Variant and Variant Library Synthesis for CROCC

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

5 diseases for CROCC: About MalaCards

large cell medulloblastoma childhood medulloblastoma medulloblastoma allergic rhinitis

rhinitis

CROCC for disorders About GeneDecksing

Export disorders for CROCC gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CROCC gene, integrated from 9 sources (see all 25):
(articles sorted by number of sources associating them with CROCC)

Utopia: connect your pdf to the dynamic
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Rootletin forms centriole-associated filaments and functions in centrosome cohesion. (PubMed id 16203858)^{1, 2, 9} Bahe S.... Nigg E.A. (2005)
Rootletin, a novel coiled-coil protein, is a structural component of the ciliary rootlet. (PubMed id 12427867)^{1, 3, 9} Yang J....Li T. (2002)
Tissue expression patterns identify mouse cilia genes. (PubMed id 17971504)^{1, 3} McClintock T.S....Bergman D.A. (2008)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
Proteomic characterization of the human centrosome by protein correlation profiling. (PubMed id 14654843)^{1, 2} Andersen J.S....Mann M. (2003)
Novel tumor antigens identified by autologous antibody screening of childhood medulloblastoma cDNA libraries. (PubMed id 12800201)^{1, 2} Behrends U.... Mautner J. (2003)
Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PubMed id 9455484)^{1, 2} Seki N.... Ohara O. (1997)
beta-Catenin is a Nek2 substrate involved in centrosome separation. (PubMed id 18086858)^{1, 9} Bahmanyar S....Barth A.I. (2008)
Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)¹ Varjosalo M....Superti-Furga G. (2013)
The functional interactome landscape of the human hist one deacetylase family. (PubMed id 23752268)¹ Joshi P....Cristea I.M. (2013)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 9696	HGNC: 21299	AceView: CROCC	Ensembl:ENSG00000058453	euGenes: HUgn9696
ECgene: CROCC	H-InvDB: CROCC

(According to HUGE)
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HUGE: KIAA0445

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CROCC	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CROCC gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CROCC gene:
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GeneCards and IP:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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CROCC Gene

Ciliary Rootlet Coiled-Coil, Rootletin

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CROCC Gene

Ciliary Rootlet Coiled-Coil, Rootletin

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