Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CROCC Gene

Aliases for CROCC Gene

  • Ciliary Rootlet Coiled-Coil, Rootletin 2 3
  • Ciliary Rootlet Coiled-Coil Protein 3 4
  • Rootletin 2 3
  • Rootletin, Ciliary Rootlet Protein 3
  • Ciliary Rootlet Protein 2
  • Tax1-Binding Protein 2 3
  • KIAA0445 4
  • ROLT 3

External Ids for CROCC Gene

Summaries for CROCC Gene

GeneCards Summary for CROCC Gene

CROCC (Ciliary Rootlet Coiled-Coil, Rootletin) is a Protein Coding gene. Diseases associated with CROCC include medulloblastoma. GO annotations related to this gene include structural molecule activity and kinesin binding. An important paralog of this gene is CEP250.

UniProtKB/Swiss-Prot for CROCC Gene

  • Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus. Contributes to centrosome cohesion before mitosis.

Gene Wiki entry for CROCC Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CROCC Gene

Genomics for CROCC Gene

Genomic Location for CROCC Gene

Start:
16,740,273 bp from pter
End:
16,972,979 bp from pter
Size:
232,707 bases
Orientation:
Plus strand

Genomic View for CROCC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CROCC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CROCC Gene

Regulatory Elements for CROCC Gene

Proteins for CROCC Gene

  • Protein details for CROCC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TZA2-CROCC_HUMAN
    Recommended name:
    Rootletin
    Protein Accession:
    Q5TZA2
    Secondary Accessions:
    • Q2VHY3
    • Q66GT7
    • Q7Z2L4
    • Q7Z5D7

    Protein attributes for CROCC Gene

    Size:
    2017 amino acids
    Molecular mass:
    228523 Da
    Quaternary structure:
    • Homopolymer. Interacts with KLC3, NEK2 and the N-terminus of CEP250.

    Alternative splice isoforms for CROCC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CROCC Gene

Proteomics data for CROCC Gene at MOPED

Post-translational modifications for CROCC Gene

  • Phosphorylated by NEK2 which may regulate its association with centrosomes.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CROCC Gene

No data available for DME Specific Peptides for CROCC Gene

Domains for CROCC Gene

Protein Domains for CROCC Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

CROCC_HUMAN
Family:
  • Belongs to the rootletin family.:
    • Q5TZA2
genes like me logo Genes that share domains with CROCC: view

No data available for Gene Families for CROCC Gene

Function for CROCC Gene

Molecular function for CROCC Gene

UniProtKB/Swiss-Prot Function: Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus. Contributes to centrosome cohesion before mitosis.

Gene Ontology (GO) - Molecular Function for CROCC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity ISS --
GO:0005515 protein binding IPI 18086858
GO:0019894 kinesin binding ISS --
genes like me logo Genes that share ontologies with CROCC: view
genes like me logo Genes that share phenotypes with CROCC: view

Animal Models for CROCC Gene

MGI Knock Outs for CROCC:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for CROCC Gene

Localization for CROCC Gene

Subcellular locations from UniProtKB/Swiss-Prot for CROCC Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=In ciliated cells, associated with ciliary rootlets. In non-ciliated cells, localized between, around and at the proximal ends of the centrioles. Dissociates from the centrioles at the onset of mitosis and reassociates with them at anaphase.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CROCC Gene COMPARTMENTS Subcellular localization image for CROCC gene
Compartment Confidence
cytoskeleton 5
plasma membrane 4
cytosol 3
nucleus 3

Gene Ontology (GO) - Cellular Components for CROCC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome IDA --
GO:0005814 centriole ISS --
GO:0005886 plasma membrane IDA --
GO:0015629 actin cytoskeleton IDA --
genes like me logo Genes that share ontologies with CROCC: view

Pathways for CROCC Gene

SuperPathways for CROCC Gene

No Data Available

Gene Ontology (GO) - Biological Process for CROCC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0008104 protein localization IMP 18086858
GO:0010457 centriole-centriole cohesion IMP 24554434
GO:0016192 vesicle-mediated transport --
GO:0030030 cell projection organization IEA --
genes like me logo Genes that share ontologies with CROCC: view

No data available for Pathways by source for CROCC Gene

Transcripts for CROCC Gene

Unigene Clusters for CROCC Gene

Ciliary rootlet coiled-coil, rootletin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CROCC Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18a · 18b ^ 19 ^ 20a ·
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

ExUns: 20b ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26a · 26b · 26c ^ 27a · 27b · 27c · 27d
SP1: - - -
SP2: -
SP3:
SP4:
SP5: - - - - - - -
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for CROCC Gene

GeneLoc Exon Structure for
CROCC
ECgene alternative splicing isoforms for
CROCC

Expression for CROCC Gene

mRNA expression in normal human tissues for CROCC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CROCC Gene

SOURCE GeneReport for Unigene cluster for CROCC Gene Hs.309403

genes like me logo Genes that share expressions with CROCC: view

Orthologs for CROCC Gene

This gene was present in the common ancestor of animals.

Orthologs for CROCC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CROCC 36
  • 98.91 (n)
  • 98.96 (a)
CROCC 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CROCC 36
  • 86.29 (n)
  • 84.22 (a)
CROCC 37
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CROCC 36
  • 88.06 (n)
  • 87.57 (a)
CROCC 37
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Crocc 36
  • 83.45 (n)
  • 83.05 (a)
Crocc 16
Crocc 37
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CROCC 37
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CROCC 37
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Crocc 36
  • 83.35 (n)
  • 84.18 (a)
chicken
(Gallus gallus)
Aves CROCC 36
  • 63.2 (n)
  • 51.72 (a)
CROCC 37
  • 45 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 55 (a)
OneToMany
-- 37
  • 48 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100498193 36
  • 52.91 (n)
  • 44.76 (a)
zebrafish
(Danio rerio)
Actinopterygii CABZ01072698.1 37
  • 30 (a)
ManyToMany
LOC101885282 36
  • 50.49 (n)
  • 41.15 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003449 36
  • 45.26 (n)
  • 32.51 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rootletin 36
  • 60.42 (n)
  • 51.56 (a)
Rootletin 37
  • 24 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5391 36
Species with no ortholog for CROCC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CROCC Gene

ENSEMBL:
Gene Tree for CROCC (if available)
TreeFam:
Gene Tree for CROCC (if available)

Paralogs for CROCC Gene

Paralogs for CROCC Gene

Selected SIMAP similar genes for CROCC Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CROCC: view

Variants for CROCC Gene

Sequence variations from dbSNP and Humsavar for CROCC Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs450236 -- 16,949,322(-) GGAAC(A/G)GTGCA intron-variant
rs590249 -- 16,947,733(+) GTCTG(G/T)TTTAT intron-variant
rs590800 -- 16,947,890(+) ctgga(A/G)tgcag intron-variant
rs667158 -- 16,953,657(-) AGCAG(A/G)GCAAA intron-variant
rs761424 -- 16,956,580(-) ggact(A/G)ctttc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CROCC Gene

Variant ID Type Subtype PubMed ID
dgv29e1 CNV Complex 17122850
nsv428421 CNV Gain+Loss 18775914
nsv9324 CNV Gain+Loss 18304495
dgv30e1 CNV Complex 17122850
nsv829625 CNV Gain 20364138
nsv7173 OTHER Inversion 18451855
dgv34e1 CNV Complex 17122850
esv29948 CNV Loss 18421352
dgv178n71 CNV Gain 21882294
dgv40e1 CNV Complex 17122850
esv33965 CNV Gain+Loss 17666407
dgv41e1 CNV Complex 17122850
esv26111 CNV Gain+Loss 19812545
nsv821037 CNV Duplication 20802225
nsv834258 CNV Loss 17160897
nsv834269 CNV Loss 17160897
esv990069 CNV Loss 20482838
nsv442727 CNV CNV 18776908
dgv180n71 CNV Loss 21882294
dgv23n67 CNV Gain 20364138
nsv433184 CNV Loss 18776910
dgv181n71 CNV Gain 21882294
dgv182n71 CNV Gain+Loss 21882294
esv29988 CNV Loss 17803354
esv2421455 CNV Duplication 20811451
nsv834280 CNV Loss 17160897
essv24221 CNV CNV 17122850
nsv437207 CNV Loss 16327808
dgv24n67 CNV Gain 20364138
dgv183n71 CNV Loss 21882294
dgv25n67 CNV Gain 20364138
nsv508947 CNV Insertion 20534489
dgv184n71 CNV Loss 21882294
nsv482201 CNV Gain 20164927
nsv437208 CNV Loss 16327808
nsv438355 CNV Loss 16468122
nsv471438 CNV Duplication 19718026
dgv185n71 CNV Loss 21882294
nsv871590 CNV Loss 21882294

Relevant External Links for CROCC Gene

HapMap Linkage Disequilibrium report
CROCC

Disorders for CROCC Gene

(1) MalaCards Diseases for CROCC Gene

Search for CROCC Gene in MalaCards »
genes like me logo Genes that share disorders with CROCC: view

No data available for UniProtKB/Swiss-Prot for CROCC Gene

Publications for CROCC Gene

  1. Rootletin forms centriole-associated filaments and functions in centrosome cohesion. (PMID: 16203858) Bahe S. … Nigg E.A. (J. Cell Biol. 2005) 3 4 23
  2. Rootletin, a novel coiled-coil protein, is a structural component of the ciliary rootlet. (PMID: 12427867) Yang J. … Li T. (J. Cell Biol. 2002) 2 3 23
  3. beta-Catenin is a Nek2 substrate involved in centrosome separation. (PMID: 18086858) Bahmanyar S. … Barth A.I. (Genes Dev. 2008) 3 23
  4. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PMID: 9455484) Seki N. … Ohara O. (DNA Res. 1997) 3 4
  5. Tissue expression patterns identify mouse cilia genes. (PMID: 17971504) McClintock T.S. … Bergman D.A. (Physiol. Genomics 2008) 2 3

Products for CROCC Gene

Sources for CROCC Gene

Back to Top

Content