Aliases for CROCC Gene
Aliases for CROCC Gene
External Ids for CROCC Gene
- HGNC: 21299
- Entrez Gene: 9696
- Ensembl: ENSG00000058453
- OMIM: 615776
- UniProtKB: Q5TZA2
Previous GeneCards Identifiers for CROCC Gene
- GC01P016201
- GC01P016631
- GC01P016993
- GC01P017121
- GC01P017049
- GC01P017223
- GC01P015492
- GC01P017093
- GC01P017099
- GC01P016741
- GC01P016745
- GC01P016748
- GC01P016754
- GC01P016757
- GC01P016759
- GC01P016761
Summaries for CROCC Gene
GeneCards Summary for CROCC Gene
CROCC (Ciliary Rootlet Coiled-Coil, Rootletin) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include structural molecule activity and kinesin binding. An important paralog of this gene is CROCC2.
UniProtKB/Swiss-Prot for CROCC Gene
-
Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus (By similarity). Furthermore, is required for the correct positioning of the cilium basal body relative to the cell nucleus, to allow for ciliogenesis (PubMed:27623382). Contributes to centrosome cohesion before mitosis (PubMed:16203858).
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CROCC Gene
Genomics for CROCC Gene
GeneHancer (GH) Regulatory Elements for CROCC Gene
Promoters and enhancers for CROCC Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around CROCC on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for CROCC Gene
Genomic Locations for CROCC Gene
- chr1:16,740,273-16,972,979
- (GRCh38/hg38)
- Size:
- 232,707 bases
- Orientation:
- Plus strand
- chr1:17,066,768-17,299,474
- (GRCh37/hg19)
Genomic View for CROCC Gene
Genes around CROCC on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p36.13 by Ensembl
- 1p36.13 by Entrez Gene
- 1p36.13 by HGNC
CROCC Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CROCC Gene
Proteins for CROCC Gene
-
Protein details for CROCC Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q5TZA2-CROCC_HUMAN
- Recommended name:
- Rootletin
- Protein Accession:
- Q5TZA2
- Q2VHY3
- Q66GT7
- Q7Z2L4
- Q7Z5D7
Protein attributes for CROCC Gene
- Size:
- 2017 amino acids
- Molecular mass:
- 228523 Da
- Quaternary structure:
-
- Homopolymer. Interacts with KLC3, NEK2 and the N-terminus of CEP250.
Protein Expression for CROCC Gene
Post-translational modifications for CROCC Gene
- Phosphorylated by NEK2 which may regulate its association with centrosomes.
Other Protein References for CROCC Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for CROCC
-
Abcam antibodies for CROCC
- Invitrogen Antibodies for CROCC
- antibodies-online: Search results for 6 available CROCC Antibodies ranked by validation data
- Compare Top CROCC Antibodies
-
Quality Products:
- Search GeneTex for Antibodies for CROCC
-
Santa Cruz Biotechnology (SCBT) Antibodies for CROCC
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for CROCC
- Origene Custom Protein Services for CROCC
- Novus Biologicals proteins for CROCC
- Search GeneTex for Proteins for CROCC
Assay Products
No data available for DME Specific Peptides for CROCC Gene
Domains & Families for CROCC Gene
Gene Families for CROCC Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for CROCC Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q5TZA2- Family:
-
- Belongs to the rootletin family.
Function for CROCC Gene
Molecular function for CROCC Gene
- UniProtKB/Swiss-Prot Function:
- Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus (By similarity). Furthermore, is required for the correct positioning of the cilium basal body relative to the cell nucleus, to allow for ciliogenesis (PubMed:27623382). Contributes to centrosome cohesion before mitosis (PubMed:16203858).
Phenotypes From GWAS Catalog for CROCC Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003779 | actin binding | IEA | -- |
| GO:0005198 | structural molecule activity | IEA,ISS | -- |
| GO:0005515 | protein binding | IPI | 18086858 |
| GO:0019894 | kinesin binding | ISS,IEA | -- |
Phenotypes for CROCC Gene
- MGI mutant phenotypes for CROCC:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for CROCC:
Animal Models for CROCC Gene
- MGI Knock Outs for CROCC:
-
- Crocc tm1Tili
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CROCC
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CROCC gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CROCC gene
- Search ViGene Biosciences for CROCC
CRISPR Products
-
OriGene CRISPR knockouts for CROCC
- genomics-online: gRNA clones - Search results for available CROCC gene related products
- Applied Biological Materials CRISPR for CROCC
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CROCC
- GenScript: Design CRISPR guide RNA sequences for CROCC
miRNA Products
- Search ViGene Biosciences for CROCC
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for CROCC
- Browse OriGene Inhibitory RNA Products For CROCC
- genomics-online: shRNA clones - Search results for available CROCC gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for CROCC gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for CROCC
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CROCC
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CROCC
- genomics-online: cdna clones - Search results for available CROCC gene related products
- orf clones - Search results for available CROCC gene related products
- Applied Biological Materials Clones for CROCC
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for CROCC
-
ViGene Biosciences adenoviral particle packaged cDNA for CROCC gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CROCC gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CROCC gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CROCC Gene
Localization for CROCC Gene
Subcellular locations from UniProtKB/Swiss-Prot for CROCC Gene
- Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=In ciliated cells, associated with ciliary rootlets. In non-ciliated cells, localized between, around and at the proximal ends of the centrioles. Dissociates from the centrioles at the onset of mitosis and reassociates with them at anaphase. {ECO:0000269 PubMed:14654843}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| cytoskeleton | 5 |
| cytosol | 5 |
| nucleus | 3 |
- Centrosome (3)
- Plasma membrane (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001917 | photoreceptor inner segment | IEA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005813 | centrosome | IDA | 21399614 |
| GO:0005814 | centriole | ISS,IDA | -- |
| GO:0005815 | microtubule organizing center | IEA | -- |
Pathways & Interactions for CROCC Gene
No Data Available
Interacting Proteins for CROCC Gene
Selected Interacting proteins:
Q5TZA2-CROCC_HUMAN
ENSP00000364691
for CROCC Gene via
MINT
STRING
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007049 | cell cycle | IEA | -- |
| GO:0007098 | centrosome cycle | IEA,IDA | 16203858 |
| GO:0008104 | protein localization | IMP | 18086858 |
| GO:0010457 | centriole-centriole cohesion | IMP | 24554434 |
| GO:0010669 | epithelial structure maintenance | IEA | -- |
No data available for Pathways by source for CROCC Gene
Transcripts for CROCC Gene
mRNA/cDNA for CROCC Gene
- (7) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (72) Selected AceView cDNA sequences:
- (13) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CROCC Gene
CRISPR Products
-
OriGene CRISPR knockouts for CROCC
- genomics-online: gRNA clones - Search results for available CROCC gene related products
- Applied Biological Materials CRISPR for CROCC
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CROCC
- GenScript: Design CRISPR guide RNA sequences for CROCC
miRNA Products
- Search ViGene Biosciences for CROCC
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for CROCC
- Browse OriGene Inhibitory RNA Products For CROCC
- genomics-online: shRNA clones - Search results for available CROCC gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for CROCC gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for CROCC
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CROCC
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CROCC
- genomics-online: cdna clones - Search results for available CROCC gene related products
- orf clones - Search results for available CROCC gene related products
- Applied Biological Materials Clones for CROCC
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | · | 14c | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | · | 17c | ^ | 18a | · | 18b | ^ | 19 | ^ | 20a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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| SP13: |
| ExUns: | 20b | ^ | 21a | · | 21b | ^ | 22a | · | 22b | ^ | 23a | · | 23b | ^ | 24a | · | 24b | ^ | 25 | ^ | 26a | · | 26b | · | 26c | ^ | 27a | · | 27b | · | 27c | · | 27d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||||
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| SP5: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||
| SP6: | - | ||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||||||||||
| SP11: | |||||||||||||||||||||||||||||||||
| SP12: | |||||||||||||||||||||||||||||||||
| SP13: |
Expression for CROCC Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Neutrophil (11.9), Retina (9.2), and Lymph node (7.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CROCC Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of CROCC Gene:
CROCCSOURCE GeneReport for Unigene cluster for CROCC Gene:
Hs.309403Evidence on tissue expression from TISSUES for CROCC Gene
- Eye(5)
- Nervous system(4.5)
- Liver(4.4)
- Blood(4.1)
- Lung(3.6)
- Skin(3.1)
- Intestine(2.2)
- Kidney(2.2)
- Pancreas(2.1)
Primer Products
-
OriGene qPCR primer pairs for CROCC
- genomics-online: primer clones - Search results for available CROCC gene related products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CROCC Gene
Orthologs for CROCC Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CROCC 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | CROCC 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | CROCC 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Crocc 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Crocc 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | CROCC 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | CROCC 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CROCC 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100498193 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | LOC101885282 33 |
|
||
| CABZ01072698.1 34 |
|
ManyToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | Rootletin 33 34 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP003449 33 |
|
||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.5391 33 |
|
- Species where no ortholog for CROCC was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for CROCC Gene
(4) SIMAP similar genes for CROCC Gene using alignment to 4 proteins:
Pseudogenes.org Pseudogenes for CROCC Gene
Variants for CROCC Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000179201 | -- | 16,926,884(+) | C/A | intron_variant | |
| rs1000422112 | -- | 16,943,142(+) | T/G | intron_variant | |
| rs1000437740 | -- | 16,953,205(+) | G/A | intron_variant | |
| rs1000717614 | -- | 16,926,284(+) | C/T | intron_variant | |
| rs1000726527 | -- | 16,964,090(+) | C/T | intron_variant |
Residual Variation Intolerance Score:
99.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
12.05;
93.77% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CROCC Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CROCC
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CROCC Gene
Disorders for CROCC Gene
Additional Disease Information for CROCC
No disorders were found for CROCC Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CROCC Gene
Publications for CROCC Gene
- Rootletin forms centriole-associated filaments and functions in centrosome cohesion. (PMID: 16203858) Bahe S … Nigg EA (The Journal of cell biology 2005) 3 4 22 58
- Rootletin, a novel coiled-coil protein, is a structural component of the ciliary rootlet. (PMID: 12427867) Yang J … Li T (The Journal of cell biology 2002) 2 3 22 58
- A Conserved Role for Girdin in Basal Body Positioning and Ciliogenesis. (PMID: 27623382) Nechipurenko IV … Sengupta P (Developmental cell 2016) 3 4 58
- Tissue expression patterns identify mouse cilia genes. (PMID: 17971504) McClintock TS … Bergman DA (Physiological genomics 2008) 2 3 58
- beta-Catenin is a Nek2 substrate involved in centrosome separation. (PMID: 18086858) Bahmanyar S … Barth AI (Genes & development 2008) 3 22 58
Products for CROCC Gene
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- Invitrogen Antibodies for CROCC
- Cyagen custom Knockout/knockin (KOKI) mouse models for CROCC
- VectorBuilder custom plasmid, inducible vectors for CROCC
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CROCC
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CROCC
- antibodies-online: Search results for 6 available CROCC Antibodies ranked by validation data
- Compare Top CROCC Antibodies
- Quality Products:
- antibodies-online: Search results for available CROCC related products ranked by validation data
- antibodies-online: Search results for available CROCC related products ranked by validation data
- Search GeneTex for Antibodies for CROCC
- Search GeneTex for Proteins for CROCC
- ViGene Biosciences adenoviral particle packaged cDNA for CROCC gene
- ViGene Biosciences lentiviral particle packaged cDNA for CROCC gene
- ViGene Biosciences ready-to-package AAV shRNAs for CROCC gene
- Search ViGene Biosciences for CROCC
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- Horizon Cell Lines for CROCC
- genomics-online: cdna clones - Search results for available CROCC gene related products
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- genomics-online: primer clones - Search results for available CROCC gene related products
- genomics-online: shRNA clones - Search results for available CROCC gene related products
Sources for CROCC Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
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