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CROCC Gene

protein-coding   GIFtS: 48
GCID: GC01P017099

Ciliary Rootlet Coiled-Coil, Rootletin

  See CROCC-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ciliary Rootlet Coiled-Coil, Rootletin1 2     ROLT2
rootletin1 2     Rootletin, Ciliary Rootlet Protein2
Ciliary Rootlet Coiled-Coil Protein2 3     Tax1-Binding Protein 22
Ciliary Rootlet Protein1     KIAA04453

External Ids:    HGNC: 212991   Entrez Gene: 96962   Ensembl: ENSG000000584537   UniProtKB: Q5TZA23   

Export aliases for CROCC gene to outside databases

Previous GC identifers: GC01P016201 GC01P016631 GC01P016993 GC01P017121 GC01P017049 GC01P017223 GC01P015492 GC01P017093


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CROCC Gene:
CROCC (ciliary rootlet coiled-coil, rootletin) is a protein-coding gene. Diseases associated with CROCC include medulloblastoma. GO annotations related to this gene include structural molecule activity and kinesin binding. An important paralog of this gene is LOC728763.

UniProtKB/Swiss-Prot: CROCC_HUMAN, Q5TZA2
Function: Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which
originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus.
Contributes to centrosome cohesion before mitosis

Gene Wiki entry for CROCC Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CROCC gene promoter:
         NF-1   NF-1/L   p300   Pax-2   AP-4   Pax-2a   AREB6   E2F-1   E2F   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCROCC promoter sequence
   Search Chromatin IP Primers for CROCC

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CROCC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.13   Ensembl cytogenetic band:  1p36.13   HGNC cytogenetic band: 1p36.13

CROCC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CROCC gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P017099:  view genomic region     (about GC identifiers)

Start:
17,066,768 bp from pter      End:
17,299,474 bp from pter
Size:
232,707 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CROCC_HUMAN, Q5TZA2 (See protein sequence)
Recommended Name: Rootletin  
Size: 2017 amino acids; 228523 Da
Subunit: Homopolymer. Interacts with KLC3, NEK2 and the N-terminus of CEP250
Secondary accessions: Q2VHY3 Q66GT7 Q7Z2L4 Q7Z5D7
Alternative splicing: 2 isoforms:  Q5TZA2-1   Q5TZA2-2   

Explore the universe of human proteins at neXtProt for CROCC: NX_Q5TZA2

Explore proteomics data for CROCC at MOPED

Post-translational modifications: 

  • Phosphorylated by NEK2 which may regulate its association with centrosomes1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CROCC Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055490.3  
    ENSEMBL proteins: 
     ENSP00000364691   ENSP00000402626  

    CROCC Human Recombinant Protein Products:

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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for CROCC 

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    Abcam antibodies for CROCC
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    Browse ELISAs at Cloud-Clone Corp.
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    Search eBioscience for ELISAs for CROCC 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR026733 Rootletin

    Graphical View of Domain Structure for InterPro Entry Q5TZA2

    ProtoNet protein and cluster: Q5TZA2

    UniProtKB/Swiss-Prot: CROCC_HUMAN, Q5TZA2
    Similarity: Belongs to the rootletin family


    Find genes that share domains with CROCC           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CROCC_HUMAN, Q5TZA2
    Function: Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which
    originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus.
    Contributes to centrosome cohesion before mitosis

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity ISS--
    GO:0005515protein binding IPI18086858
    GO:0019894kinesin binding ISS--
         
    Find genes that share ontologies with CROCC           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for CROCC:
     Decreased BPV1 E2 protein expr  Increased HPV18 LCR reporter a 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Crocc):
     immune system  nervous system  respiratory system  vision/eye 

    Find genes that share phenotypes with CROCC           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Crocctm1Tili for CROCC

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CROCC
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CROCC

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CROCC
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CROCC

    miRNA
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    Block miRNA regulation of human, mouse, rat CROCC using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CROCC (see all 9):
    hsa-miR-3163 hsa-miR-520d-5p hsa-miR-4306 hsa-miR-548m hsa-miR-185 hsa-miR-3613-3p hsa-miR-3143 hsa-miR-524-5p
    SwitchGear 3'UTR luciferase reporter plasmidCROCC 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CROCC

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    GenScript: all cDNA clones in your preferred vector: CROCC (NM_014675)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CROCC
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CROCC
    Addgene plasmids for CROCC 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CROCC_HUMAN, Q5TZA2: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=In
    ciliated cells, associated with ciliary rootlets. In non-ciliated cells, localized between, around and at the
    proximal ends of the centrioles. Dissociates from the centrioles at the onset of mitosis and reassociates with
    them at anaphase
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    plasma membrane4
    cytosol3
    nucleus3

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005813centrosome IDA--
    GO:0005814centriole ISS--
    GO:0005886plasma membrane IDA--
    GO:0015629actin cytoskeleton IDA--

    Find genes that share ontologies with CROCC           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CROCC
    Interactions:

        GeneGlobe Interaction Network for CROCC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for CROCC (Q5TZA23 ENSP000003646914) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    KLC3Q6P5973, ENSP000003758104I2D: score=1 STRING: ENSP00000375810
    MAPK1P284823I2D: score=1 
    SUN5ENSP000003484964STRING: ENSP00000348496
    RNF152ENSP000003166284STRING: ENSP00000316628
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007049cell cycle IEA--
    GO:0008104protein localization IMP18086858
    GO:0016192vesicle-mediated transport ----
    GO:0030030cell projection organization IEA--
    GO:0051297centrosome organization IDA16203858

    Find genes that share ontologies with CROCC           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CROCC



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CROCC gene: 
    NM_014675.3  

    Unigene Cluster for CROCC:

    Ciliary rootlet coiled-coil, rootletin
    Hs.309403  [show with all ESTs]
    Unigene Representative Sequence: NM_014675
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000466256(uc009voy.1) ENST00000375541(uc009voz.1 uc001azt.2 uc001azu.2 uc001azv.2)
    ENST00000445545 ENST00000467938 ENST00000492631 ENST00000467715 ENST00000494191
    ENST00000486318 ENST00000498688 ENST00000477773 ENST00000497654 ENST00000465021
    ENST00000465291
    miRNA
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    Block miRNA regulation of human, mouse, rat CROCC using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CROCC (see all 9):
    hsa-miR-3163 hsa-miR-520d-5p hsa-miR-4306 hsa-miR-548m hsa-miR-185 hsa-miR-3613-3p hsa-miR-3143 hsa-miR-524-5p
    SwitchGear 3'UTR luciferase reporter plasmidCROCC 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CROCC
    Predesigned siRNA for gene silencing in human, mouse, rat CROCC
    Clone
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    OriGene clones in human, mouse for CROCC (see all 6)
    OriGene ORF clones in mouse, rat for CROCC
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CROCC (NM_014675)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CROCC
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CROCC
    Addgene plasmids for CROCC 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CROCC
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CROCC
      QuantiTect SYBR Green Assays in human, mouse, rat CROCC
      QuantiFast Probe-based Assays in human, mouse, rat CROCC

    Additional mRNA sequence: 

    AB007914.2 AF527734.1 AK026910.1 BC126911.1 BC126912.1 DQ139275.1 

    11 DOTS entries:

    DT.95266566  DT.100743912  DT.100020214  DT.100839518  DT.449429  DT.97840379  DT.121461770  DT.40261591 
    DT.121346580  DT.40297433  DT.92066234 

    Selected AceView cDNA sequences (see all 72):

    NM_014675 BQ073078 BM725894 AA328651 BE531043 BM689120 AB007914 CR599665 
    CA311957 BU187617 BM728452 BU634173 AA666400 BM453764 CB152210 BU727352 
    BM926940 BX343443 AF527734 BM669673 BE393305 CB306675 BV166904 BU631113 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CROCC (see all 13)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18a · 18b ^ 19 ^ 20a ·
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 20b ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26a · 26b · 26c ^ 27a · 27b · 27c · 27d
    SP1:                          -                                   -           -                           
    SP2:                          -                                                                           
    SP3:                                                                                                      
    SP4:                                                                                                      
    SP5:                    -     -     -     -                       -     -     -                           


    ECgene alternative splicing isoforms for CROCC

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CROCC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTCGGGAAA
    CROCC Expression
    About this image


    CROCC expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Ovary (Reproductive System)
             Oviduct
    CROCC Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CROCC Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.309403
        Custom PCR Arrays for CROCC
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CROCC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CROCC gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Crocc1 , 5 ciliary rootlet coiled-coil, rootletin1, 5 83.45(n)1
    83.05(a)1
      4 (73.31 cM)5
    2308721  NM_172122.21  NP_742120.21 
     1410166375 
    chicken
    (Gallus gallus)
    Aves CROCC1 ciliary rootlet coiled-coil, rootletin 63.2(n)
    51.72(a)
      428191  XM_425750.4  XP_425750.4 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    55(a)
    48(a)
    1 ↔ many
    1 ↔ many
    AAWZ02039191(901-9112)
    GL344546.1(3245-29436)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia 1377207352   -- 76.35(n)    137720735 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1018852821 rootletin-like 50.49(n)
    41.15(a)
      101885282  XM_005165956.1  XP_005166013.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rootletin1 Rootletin 60.42(n)
    51.56(a)
      42860  NM_142959.4  NP_651216.2 


    ENSEMBL Gene Tree for CROCC (if available)
    TreeFam Gene Tree for CROCC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CROCC gene
    LOC7287632  CEP2502  
    4 SIMAP similar genes for CROCC using alignment to 4 protein entries:     CROCC_HUMAN (see all proteins):
    CROCCP3    CROCCP2    CEP250    LOC728763

    Find genes that share paralogs with CROCC           About GenesLikeMe


    5 Pseudogenes.org Pseudogenes for CROCC
    PGOHUM00000243914 PGOHUM00000243917 PGOHUM00000244623 PGOHUM00000244631 PGOHUM00000242031


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CROCC (see all 1760)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs66627001,2
    C,F,A--17246540(+) tgccaC/Tcacgc 1 -- us2k15Minor allele frequency- T:0.50NA WA CSA 10
    rs353312841,2
    C--17246588(+) ATTTT-/TGAGAC 1 -- us2k12Minor allele frequency- T:0.25NA CSA 4
    rs1860185041,2
    --17246614(+) GTGTCA/GCCAGG 1 -- us2k10--------
    rs66628201,2
    C,H--17246644(+) tctcgG/Cctcac 1 -- us2k18Minor allele frequency- C:0.06NA WA CSA 16
    rs1890343231,2
    --17246666(+) CCTCCC/TAGGTT 1 -- us2k10--------
    rs1813793301,2
    --17246678(+) AAGCGA/TTTCTC 1 -- us2k10--------
    rs1853082951,2
    --17246715(+) ACTACA/GGGTGT 1 -- us2k10--------
    rs1509902521,2
    --17246934(+) CTGCCC/TGCCTC 1 -- us2k10--------
    rs1906633571,2
    --17246972(+) CTTGAA/GCCACT 1 -- us2k10--------
    rs1828801441,2
    C--17247160(+) AGCCTC/TCTTGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CROCC (17066768 - 17299474 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CROCC (see all 39):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv471438CNV Duplication19718026
    nsv821037CNV Duplication20802225
    esv2421455CNV Duplication20811451
    nsv508947CNV Insertion20534489
    nsv433184CNV Loss18776910
    nsv834269CNV Loss17160897
    dgv184n71CNV Loss21882294
    esv29988CNV Loss17803354
    dgv183n71CNV Loss21882294
    nsv834258CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for CROCC

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    1 disease for CROCC:    
    About MalaCards
    medulloblastoma


    Find genes that share disorders with CROCC           About GenesLikeMe


    Export disorders for CROCC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CROCC gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with CROCC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Rootletin forms centriole-associated filaments and functions in centrosome cohesion. (PubMed id 16203858)1, 2, 9 Bahe S.... Nigg E.A. (J. Cell Biol. 2005)
    2. Rootletin, a novel coiled-coil protein, is a structural component of the ciliary rootlet. (PubMed id 12427867)1, 3, 9 Yang J....Li T. (J. Cell Biol. 2002)
    3. Tissue expression patterns identify mouse cilia genes. (PubMed id 17971504)1, 3 McClintock T.S....Bergman D.A. (Physiol. Genomics 2008)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    5. Proteomic characterization of the human centrosome by protein correlation profiling. (PubMed id 14654843)1, 2 Andersen J.S....Mann M. (Nature 2003)
    6. Novel tumor antigens identified by autologous antibody screening of childhood medulloblastoma cDNA libraries. (PubMed id 12800201)1, 2 Behrends U.... Mautner J. (Int. J. Cancer 2003)
    7. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PubMed id 9455484)1, 2 Seki N.... Ohara O. (DNA Res. 1997)
    8. beta-Catenin is a Nek2 substrate involved in centrosome separation. (PubMed id 18086858)1, 9 Bahmanyar S....Barth A.I. (Genes Dev. 2008)
    9. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    10. The functional interactome landscape of the human histone deacetylase family. (PubMed id 23752268)1 Joshi P....Cristea I.M. (Mol. Syst. Biol. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 9696 HGNC: 21299 AceView: CROCC Ensembl:ENSG00000058453 euGenes: HUgn9696
    ECgene: CROCC H-InvDB: CROCC

    (According to HUGE)
    About This Section

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    HUGE: KIAA0445

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CROCC Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CROCC gene:
    Search GeneIP for patents involving CROCC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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