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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CROCC Gene

protein-coding   GIFtS: 47
GCID: GC01P017093

Ciliary Rootlet Coiled-Coil, Rootletin

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ciliary Rootlet Coiled-Coil, Rootletin1 2     ROLT2
rootletin1 2     Rootletin, Ciliary Rootlet Protein2
Ciliary Rootlet Coiled-Coil Protein2 3     Tax1-Binding Protein 22
Ciliary Rootlet Protein1     KIAA04453

External Ids:    HGNC: 212991   Entrez Gene: 96962   Ensembl: ENSG000000584537   UniProtKB: Q5TZA23   

Export aliases for CROCC gene to outside databases

Previous GC identifers: GC01P016201 GC01P016631 GC01P016993 GC01P017121 GC01P017049 GC01P017223 GC01P015492


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CROCC Gene: 
CROCC (ciliary rootlet coiled-coil, rootletin) is a protein-coding gene. Diseases associated with CROCC include large cell medulloblastoma, and childhood medulloblastoma. GO annotations related to this gene include structural molecule activity and kinesin binding. An important paralog of this gene is LOC728763.

UniProtKB/Swiss-Prot: CROCC_HUMAN, Q5TZA2
Function: Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which
originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus.
Contributes to centrosome cohesion before mitosis

Gene Wiki entry for CROCC Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004610.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CROCC gene promoter:
         NF-1   NF-1/L   p300   Pax-2   AP-4   Pax-2a   AREB6   E2F-1   E2F   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCROCC promoter sequence
   Search SABiosciences Chromatin IP Primers for CROCC

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CROCC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.13   Ensembl cytogenetic band:  1p36.13   HGNC cytogenetic band: 1p36.13

CROCC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CROCC gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P017093:  view genomic region     (about GC identifiers)

Start:
17,066,768 bp from pter      End:
17,299,474 bp from pter
Size:
232,707 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CROCC_HUMAN, Q5TZA2 (See protein sequence)
Recommended Name: Rootletin  
Size: 2017 amino acids; 228523 Da
Subunit: Homopolymer. Interacts with KLC3, NEK2 and the N-terminus of CEP250
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=In
ciliated cells, associated with ciliary rootlets. In non-ciliated cells, localized between, around and at the
proximal ends of the centrioles. Dissociates from the centrioles at the onset of mitosis and reassociates with
them at anaphase
Secondary accessions: Q2VHY3 Q66GT7 Q7Z2L4 Q7Z5D7
Alternative splicing: 2 isoforms:  Q5TZA2-1   Q5TZA2-2   

Explore the universe of human proteins at neXtProt for CROCC: NX_Q5TZA2

Explore proteomics data for CROCC at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated by NEK2 which may regulate its association with centrosomes
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5TZA2

  • CROCC Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CROCC Protein Expression
    REFSEQ proteins: NP_055490.3  
    ENSEMBL proteins: 
     ENSP00000364691   ENSP00000402626  

    Human Recombinant Protein Products for CROCC: 
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    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CROCC
    GenScript Custom Purified and Recombinant Proteins Services for CROCC
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005813centrosome IDA--
    GO:0005814centriole ISS--
    GO:0005886plasma membrane IDA--
    GO:0015629actin cytoskeleton IDA--

    CROCC for ontologies           About GeneDecksing



    CROCC Antibody Products: 
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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR026733 Rootletin

    Graphical View of Domain Structure for InterPro Entry Q5TZA2

    ProtoNet protein and cluster: Q5TZA2

    UniProtKB/Swiss-Prot: CROCC_HUMAN, Q5TZA2
    Similarity: Belongs to the rootletin family


    CROCC for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CROCC_HUMAN, Q5TZA2
    Function: Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which
    originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus.
    Contributes to centrosome cohesion before mitosis

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity ISS--
    GO:0005515protein binding IPI18086858
    GO:0019894kinesin binding ISS--
         
    CROCC for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CROCC:
     Decreased BPV1 E2 protein expr  Increased HPV18 LCR reporter a 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Crocc):
     immune system  nervous system  respiratory system  vision/eye 

    CROCC for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Crocctm1Tili for CROCC

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CROCC 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CROCC

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CROCC 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CROCC 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CROCC
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate CROCC (see all 9):
    hsa-miR-3163 hsa-miR-520d-5p hsa-miR-4306 hsa-miR-548m hsa-miR-185 hsa-miR-3613-3p hsa-miR-3143 hsa-miR-524-5p
    SwitchGear 3'UTR luciferase reporter plasmidCROCC 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CROCC
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CROCC

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for CROCC
    Sirion Biotech Customized adenovirus for overexpression of CROCC

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CROCC (see all 6)
    OriGene ORF clones in mouse, rat for CROCC
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CROCC (NM_014675)
    Browse Sino Biological Human cDNA Clones
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    Search LifeMap BioReagents cell lines for CROCC
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CROCC


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CROCC

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for CROCC (Q5TZA23 ENSP000003646914) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    KLC3Q6P5973, ENSP000003758104I2D: score=1 STRING: ENSP00000375810
    MAPK1P284823I2D: score=1 
    RNF152ENSP000003166284STRING: ENSP00000316628
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007049cell cycle IEA--
    GO:0008104protein localization IMP18086858
    GO:0016192vesicle-mediated transport ----
    GO:0030030cell projection organization IEA--
    GO:0051297centrosome organization IDA16203858

    CROCC for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CROCC

    Search CenterWatch for drugs/clinical trials and news about CROCC

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CROCC gene: 
    NM_014675.3  

    Unigene Cluster for CROCC:

    Ciliary rootlet coiled-coil, rootletin
    Hs.309403  [show with all ESTs]
    Unigene Representative Sequence: NM_014675
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000466256(uc009voy.1) ENST00000375541(uc009voz.1 uc001azt.2 uc001azu.2 uc001azv.2)
    ENST00000445545 ENST00000467938 ENST00000492631 ENST00000467715 ENST00000494191
    ENST00000486318 ENST00000498688 ENST00000477773 ENST00000497654 ENST00000465021
    ENST00000465291
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CROCC
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate CROCC (see all 9):
    hsa-miR-3163 hsa-miR-520d-5p hsa-miR-4306 hsa-miR-548m hsa-miR-185 hsa-miR-3613-3p hsa-miR-3143 hsa-miR-524-5p
    SwitchGear 3'UTR luciferase reporter plasmidCROCC 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CROCC
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CROCC
    Clone
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    OriGene clones in human, mouse for CROCC (see all 6)
    OriGene ORF clones in mouse, rat for CROCC
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CROCC (NM_014675)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CROCC
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CROCC
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CROCC
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CROCC
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CROCC
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CROCC

    Additional mRNA sequence: 

    AB007914.2 AF527734.1 AK026910.1 BC126911.1 BC126912.1 DQ139275.1 

    11 DOTS entries:

    DT.95266566  DT.100743912  DT.100020214  DT.100839518  DT.449429  DT.97840379  DT.121461770  DT.40261591 
    DT.121346580  DT.40297433  DT.92066234 

    24/72 AceView cDNA sequences (see all 72):

    BM725894 AA328651 BE531043 BM689120 BQ073078 NM_014675 AB007914 CR599665 
    CA414341 AI969545 CB306675 BV166904 BU631113 AW295613 BQ575557 BM460873 
    BX354187 BM549828 BQ432416 AA359769 BM678006 BQ003345 AA622336 BM763603 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for CROCC (see all 13)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18a · 18b ^ 19 ^ 20a ·
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 20b ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26a · 26b · 26c ^ 27a · 27b · 27c · 27d
    SP1:                          -                                   -           -                           
    SP2:                          -                                                                           
    SP3:                                                                                                      
    SP4:                                                                                                      
    SP5:                    -     -     -     -                       -     -     -                           


    ECgene alternative splicing isoforms for CROCC

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CROCC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTCGGGAAA
    CROCC Expression
    About this image


    See CROCC Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CROCC

    SOURCE GeneReport for Unigene cluster: Hs.309403
        SABiosciences Custom PCR Arrays for CROCC
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CROCC
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CROCC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CROCC gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Crocc1 , 5 ciliary rootlet coiled-coil, rootletin1, 5 83.45(n)1
    83.05(a)1
      4 (73.31 cM)5
    2308721  NM_172122.21  NP_742120.21 
     1410166375 
    chicken
    (Gallus gallus)
    Aves CROCC6
    ciliary rootlet coiled-coil, rootletin
    46(a)
    1 ↔ 1
    21(4392909-4410627)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    55(a)
    49(a)
    1 ↔ many
    1 ↔ many
    AAWZ02039191(901-9112)
    GL344546.1(3245-29436)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia 1377207352   -- 76.35(n)    137720735 
    zebrafish
    (Danio rerio)
    Actinopterygii CABZ01094378.16
    Uncharacterized protein
    24(a)
    1 ↔ 1
    22(78-4766)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG61291 CG6129 45.08(n)
    29.01(a)
      42860  NM_142959.4  NP_651216.2 
    worm
    (Caenorhabditis elegans)
    Secernentea dyf-141 Protein DYF-14 37.83(n)
    25.23(a)
      173801  NM_062419.4  NP_494820.3 


    ENSEMBL Gene Tree for CROCC (if available)
    TreeFam Gene Tree for CROCC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CROCC gene
    LOC7287632  CEP2502  
    4 SIMAP similar genes for CROCC using alignment to 4 protein entries:     CROCC_HUMAN (see all proteins):
    CROCCP3    CROCCP2    CEP250    LOC728763

    CROCC for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for CROCC
    PGOHUM00000243914 PGOHUM00000243917 PGOHUM00000244623 PGOHUM00000244631 PGOHUM00000242031


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1760 SNPs in CROCC are shown (see all 1760)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs66627001,2
    C,F,A--17246540(+) tgccaC/Tcacgc 1 -- us2k15Minor allele frequency- T:0.50NA WA CSA 10
    rs353312841,2
    C--17246588(+) ATTTT-/TGAGAC 1 -- us2k12Minor allele frequency- T:0.25NA CSA 4
    rs1860185041,2
    --17246614(+) GTGTCA/GCCAGG 1 -- us2k10--------
    rs66628201,2
    C,H--17246644(+) tctcgG/Cctcac 1 -- us2k18Minor allele frequency- C:0.06NA WA CSA 16
    rs1890343231,2
    --17246666(+) CCTCCC/TAGGTT 1 -- us2k10--------
    rs1813793301,2
    --17246678(+) AAGCGA/TTTCTC 1 -- us2k10--------
    rs1853082951,2
    --17246715(+) ACTACA/GGGTGT 1 -- us2k10--------
    rs1509902521,2
    --17246934(+) CTGCCC/TGCCTC 1 -- us2k10--------
    rs1906633571,2
    --17246972(+) CTTGAA/GCCACT 1 -- us2k10--------
    rs1828801441,2
    C--17247160(+) AGCCTC/TCTTGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CROCC (17066768 - 17299474 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/39 variations for CROCC (see all 39):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv471438CNV Duplication19718026
    nsv821037CNV Duplication20802225
    esv2421455CNV Duplication20811451
    nsv508947CNV Insertion20534489
    nsv433184CNV Loss18776910
    nsv834269CNV Loss17160897
    dgv184n71CNV Loss21882294
    esv29988CNV Loss17803354
    dgv183n71CNV Loss21882294
    nsv834258CNV Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    5 diseases for CROCC:    About MalaCards
    large cell medulloblastoma    childhood medulloblastoma    medulloblastoma    allergic rhinitis
    rhinitis


    CROCC for disorders           About GeneDecksing


    Export disorders for CROCC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CROCC gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with CROCC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Rootletin forms centriole-associated filaments and functions in centrosome cohesion. (PubMed id 16203858)1, 2, 9 Bahe S.... Nigg E.A. (2005)
    2. Rootletin, a novel coiled-coil protein, is a structural component of the ciliary rootlet. (PubMed id 12427867)1, 3, 9 Yang J....Li T. (2002)
    3. Tissue expression patterns identify mouse cilia genes. (PubMed id 17971504)1, 3 McClintock T.S....Bergman D.A. (2008)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    5. Proteomic characterization of the human centrosome by protein correlation profiling. (PubMed id 14654843)1, 2 Andersen J.S....Mann M. (2003)
    6. Novel tumor antigens identified by autologous antibody screening of childhood medulloblastoma cDNA libraries. (PubMed id 12800201)1, 2 Behrends U.... Mautner J. (2003)
    7. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PubMed id 9455484)1, 2 Seki N.... Ohara O. (1997)
    8. beta-Catenin is a Nek2 substrate involved in centrosome separation. (PubMed id 18086858)1, 9 Bahmanyar S....Barth A.I. (2008)
    9. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    10. The functional interactome landscape of the human hist one deacetylase family. (PubMed id 23752268)1 Joshi P....Cristea I.M. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9696 HGNC: 21299 AceView: CROCC Ensembl:ENSG00000058453 euGenes: HUgn9696
    ECgene: CROCC H-InvDB: CROCC

    (According to HUGE)
    About This Section
    HUGE: KIAA0445

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CROCC Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CROCC gene:
    Search GeneIP for patents involving CROCC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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