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CROCC Gene

protein-coding GIFtS: 48
GCID: GC01P017099

Ciliary Rootlet Coiled-Coil, Rootletin

See CROCC-related disease
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Ciliary Rootlet Coiled-Coil, Rootletin¹ ²		ROLT²
rootletin¹ ²		Rootletin, Ciliary Rootlet Protein²
Ciliary Rootlet Coiled-Coil Protein² ³		Tax1-Binding Protein 2²
Ciliary Rootlet Protein¹		KIAA0445³

External Ids:	HGNC: 21299¹	Entrez Gene: 9696²	Ensembl: ENSG00000058453⁷	UniProtKB: Q5TZA2³

Export aliases for CROCC gene to outside databases

Previous GC identifers: GC01P016201 GC01P016631 GC01P016993 GC01P017121 GC01P017049 GC01P017223 GC01P015492 GC01P017093

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CROCC Gene:

CROCC (ciliary rootlet coiled-coil, rootletin) is a protein-coding gene. Diseases associated with CROCC include medulloblastoma. GO annotations related to this gene include structural molecule activity and kinesin binding. An important paralog of this gene is LOC728763.

UniProtKB/Swiss-Prot: CROCC_HUMAN, Q5TZA2

Function: Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which

originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus.

Contributes to centrosome cohesion before mitosis

Gene Wiki entry for CROCC Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000001.10 NT_032977.10 NC_018912.2

Regulatory elements:

Regulatory transcription factor binding sites in the CROCC gene promoter:
NF-1 NF-1/L p300 Pax-2 AP-4 Pax-2a AREB6 E2F-1 E2F ZID
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CROCC promoter sequence

Search Chromatin IP Primers for CROCC

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CROCC

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.13 Ensembl cytogenetic band: 1p36.13 HGNC cytogenetic band: 1p36.13

CROCC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CROCC gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P017099: view genomic region (about GC identifiers)

Start:	17,066,768 bp from pter	End:	17,299,474 bp from pter
Size:	232,707 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CROCC_HUMAN, Q5TZA2 (See protein sequence)

Recommended Name: Rootletin

Size: 2017 amino acids; 228523 Da

Subunit: Homopolymer. Interacts with KLC3, NEK2 and the N-terminus of CEP250

Secondary accessions: Q2VHY3 Q66GT7 Q7Z2L4 Q7Z5D7

Alternative splicing: 2 isoforms: Q5TZA2-1 Q5TZA2-2

Explore the universe of human proteins at neXtProt for CROCC: NX_Q5TZA2

Explore proteomics data for CROCC at MOPED

Post-translational modifications:

Phosphorylated by NEK2 which may regulate its association with centrosomes¹

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

See CROCC Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_055490.3

ENSEMBL proteins:

ENSP00000364691 ENSP00000402626

CROCC Human Recombinant Protein Products:

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	Search eBioscience for ELISAs for CROCC
	antibodies-online kits for CROCC (4 products)

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:

IPR026733 Rootletin

Graphical View of Domain Structure for InterPro Entry Q5TZA2

ProtoNet protein and cluster: Q5TZA2

UniProtKB/Swiss-Prot: CROCC_HUMAN, Q5TZA2

Similarity: Belongs to the rootletin family

Find genes that share domains with CROCC About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: CROCC_HUMAN, Q5TZA2

Function: Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which

originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus.

Contributes to centrosome cohesion before mitosis

Gene Ontology (GO): 3 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005198	structural molecule activity	ISS	--
GO:0005515	protein binding	IPI	18086858
GO:0019894	kinesin binding	ISS	--

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Phenotypes:
2 GenomeRNAi human phenotypes for CROCC:

Decreased BPV1 E2 protein expr

Increased HPV18 LCR reporter a

4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Crocc):

immune system

nervous system

respiratory system

vision/eye

Find genes that share phenotypes with CROCC About GenesLikeMe

Animal Models:
MGI mouse knock-out Crocc^tm1Tili for CROCC

genOway: Develop your customized and physiologically relevant rodent model for CROCC

miRNA Products:		Block miRNA regulation of human, mouse, rat CROCC using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate CROCC (see all 9):
		hsa-miR-3163 hsa-miR-520d-5p hsa-miR-4306 hsa-miR-548m hsa-miR-185 hsa-miR-3613-3p hsa-miR-3143 hsa-miR-524-5p

		SwitchGear 3'UTR luciferase reporter plasmid: CROCC 3' UTR sequence

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Gene Editing
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In Situ Assay
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

CROCC_HUMAN, Q5TZA2: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=In

ciliated cells, associated with ciliary rootlets. In non-ciliated cells, localized between, around and at the

proximal ends of the centrioles. Dissociates from the centrioles at the onset of mitosis and reassociates with

them at anaphase

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
cytoskeleton	5
plasma membrane	4
cytosol	3
nucleus	3

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Gene Ontology (GO): Selected cellular component terms (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	--
GO:0005813	centrosome	IDA	--
GO:0005814	centriole	ISS	--
GO:0005886	plasma membrane	IDA	--
GO:0015629	actin cytoskeleton	IDA	--

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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Custom Pathway & Disease-focused RT² Profiler PCR Arrays for CROCC
Interactions:

GeneGlobe Interaction Network for CROCC

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

Selected Interacting proteins for CROCC (Q5TZA2³ ENSP00000364691⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 9)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MYC	P01106³, ENSP00000367207⁴	I2D: score=1 STRING: ENSP00000367207
KLC3	Q6P597³, ENSP00000375810⁴	I2D: score=1 STRING: ENSP00000375810
MAPK1	P28482³	I2D: score=1
SUN5	ENSP00000348496⁴	STRING: ENSP00000348496
RNF152	ENSP00000316628⁴	STRING: ENSP00000316628

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Gene Ontology (GO): 5 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007049	cell cycle	IEA	--
GO:0008104	protein localization	IMP	18086858
GO:0016192	vesicle-mediated transport	--	--
GO:0030030	cell projection organization	IEA	--
GO:0051297	centrosome organization	IDA	16203858

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for CROCC

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for CROCC gene:

NM_014675.3

Unigene Cluster for CROCC:

Ciliary rootlet coiled-coil, rootletin

Hs.309403 [show with all ESTs]

Unigene Representative Sequence: NM_014675

13 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000466256(uc009voy.1) ENST00000375541(uc009voz.1 uc001azt.2 uc001azu.2 uc001azv.2)

ENST00000445545 ENST00000467938 ENST00000492631 ENST00000467715 ENST00000494191

ENST00000486318 ENST00000498688 ENST00000477773 ENST00000497654 ENST00000465021

ENST00000465291

miRNA Products:		Block miRNA regulation of human, mouse, rat CROCC using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate CROCC (see all 9):
		hsa-miR-3163 hsa-miR-520d-5p hsa-miR-4306 hsa-miR-548m hsa-miR-185 hsa-miR-3613-3p hsa-miR-3143 hsa-miR-524-5p

		SwitchGear 3'UTR luciferase reporter plasmid: CROCC 3' UTR sequence

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		GenScript: all cDNA clones in your preferred vector: CROCC (NM_014675)
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		Addgene plasmids for CROCC

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		Pre-validated RT² qPCR Primer Assay in human, mouse, rat CROCC
		QuantiTect SYBR Green Assays in human, mouse, rat CROCC
		QuantiFast Probe-based Assays in human, mouse, rat CROCC

Additional mRNA sequence:

AB007914.2 AF527734.1 AK026910.1 BC126911.1 BC126912.1 DQ139275.1

11 DOTS entries:

DT.95266566 DT.100743912 DT.100020214 DT.100839518 DT.449429 DT.97840379 DT.121461770 DT.40261591

DT.121346580 DT.40297433 DT.92066234

Selected AceView cDNA sequences (see all 72):

NM_014675 BQ073078 BM725894 AA328651 BE531043 BM689120 AB007914 CR599665

CA311957 BU187617 BM728452 BU634173 AA666400 BM453764 CB152210 BU727352

BM926940 BX343443 AF527734 BM669673 BE393305 CB306675 BV166904 BU631113

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for CROCC (see all 13) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11a	·	11b	^	12	^	13	^	14a	·	14b	·	14c	^	15	^	16	^	17a	·	17b	·	17c	^	18a	·	18b	^	19	^	20a	·
SP1:
SP2:
SP3:
SP4:
SP5:

ExUns:	20b	^	21a	·	21b	^	22a	·	22b	^	23a	·	23b	^	24a	·	24b	^	25	^	26a	·	26b	·	26c	^	27a	·	27b	·	27c	·	27d
SP1:									-												-				-
SP2:									-
SP3:
SP4:
SP5:							-		-		-		-								-		-		-

ECgene alternative splicing isoforms for CROCC

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CROCC expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TGTCGGGAAA

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CROCC expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database


Ovary (Reproductive System)
Oviduct

CROCC Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

CROCC Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.309403

Custom PCR Arrays for CROCC

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for CROCC gene from Selected species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Crocc^{1 , 5}	ciliary rootlet coiled-coil, rootletin^{1, 5}	83.45(n)¹ 83.05(a)¹		4 (73.31 cM)⁵ 230872¹ NM_172122.2¹ NP_742120.2¹ 141016637⁵
chicken (Gallus gallus)	Aves	CROCC¹	ciliary rootlet coiled-coil, rootletin	63.2(n) 51.72(a)		428191 XM_425750.4 XP_425750.4
lizard (Anolis carolinensis)	Reptilia	-- --	Uncharacterized protein	55(a) 48(a)	1 ↔ many 1 ↔ many	AAWZ02039191(901-9112) GL344546.1(3245-29436)
tropical clawed frog (Xenopus tropicalis)	Amphibia	137720735²	--	76.35(n)		137720735
zebrafish (Danio rerio)	Actinopterygii	LOC101885282¹	rootletin-like	50.49(n) 41.15(a)		101885282 XM_005165956.1 XP_005166013.1
fruit fly (Drosophila melanogaster)	Insecta	Rootletin¹	Rootletin	60.42(n) 51.56(a)		42860 NM_142959.4 NP_651216.2

ENSEMBL Gene Tree for CROCC (if available)
TreeFam Gene Tree for CROCC (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for CROCC gene

LOC728763² CEP250²

4 SIMAP similar genes for CROCC using alignment to 4 protein entries: CROCC_HUMAN (see all proteins):

CROCCP3 CROCCP2 CEP250 LOC728763

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5 Pseudogenes.org Pseudogenes for CROCC
PGOHUM00000243914 PGOHUM00000243917 PGOHUM00000244623 PGOHUM00000244631 PGOHUM00000242031

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs6662700^1,2	C,F,A	--	17246540(+)	`tgccaC/Tcacgc`	1	--	us2k¹		5		NA WA CSA	10
rs35331284^1,2	C	--	17246588(+)	`ATTTT-/TGAGAC`	1	--	us2k¹		2		NA CSA	4
rs186018504^1,2		--	17246614(+)	`GTGTCA/GCCAGG`	1	--	us2k¹		0	--	--	--	--
rs6662820^1,2	C,H	--	17246644(+)	`tctcgG/Cctcac`	1	--	us2k¹		8		NA WA CSA	16
rs189034323^1,2		--	17246666(+)	`CCTCCC/TAGGTT`	1	--	us2k¹		0	--	--	--	--
rs181379330^1,2		--	17246678(+)	`AAGCGA/TTTCTC`	1	--	us2k¹		0	--	--	--	--
rs185308295^1,2		--	17246715(+)	`ACTACA/GGGTGT`	1	--	us2k¹		0	--	--	--	--
rs150990252^1,2		--	17246934(+)	`CTGCCC/TGCCTC`	1	--	us2k¹		0	--	--	--	--
rs190663357^1,2		--	17246972(+)	`CTTGAA/GCCACT`	1	--	us2k¹		0	--	--	--	--
rs182880144^1,2	C	--	17247160(+)	`AGCCTC/TCTTGC`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CROCC (17066768 - 17299474 bp)

Structural Variations
Database of Genomic Variants (DGV) Selected variations for CROCC (see all 39): About this table

Variant ID	Type	Subtype	PubMed ID
nsv471438	CNV	Duplication	19718026
nsv821037	CNV	Duplication	20802225
esv2421455	CNV	Duplication	20811451
nsv508947	CNV	Insertion	20534489
nsv433184	CNV	Loss	18776910
nsv834269	CNV	Loss	17160897
dgv184n71	CNV	Loss	21882294
esv29988	CNV	Loss	17803354
dgv183n71	CNV	Loss	21882294
nsv834258	CNV	Loss	17160897

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing CROCC

DNA2.0 Custom Variant and Variant Library Synthesis for CROCC

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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1 disease for CROCC:
About MalaCards

medulloblastoma

Find genes that share disorders with CROCC About GenesLikeMe

Export disorders for CROCC gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CROCC gene, integrated from 10 sources (see all 26):
(articles sorted by number of sources associating them with CROCC)

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Rootletin forms centriole-associated filaments and functions in centrosome cohesion. (PubMed id 16203858)^{1, 2, 9} Bahe S.... Nigg E.A. (J. Cell Biol. 2005)
Rootletin, a novel coiled-coil protein, is a structural component of the ciliary rootlet. (PubMed id 12427867)^{1, 3, 9} Yang J....Li T. (J. Cell Biol. 2002)
Tissue expression patterns identify mouse cilia genes. (PubMed id 17971504)^{1, 3} McClintock T.S....Bergman D.A. (Physiol. Genomics 2008)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (Nature 2006)
Proteomic characterization of the human centrosome by protein correlation profiling. (PubMed id 14654843)^{1, 2} Andersen J.S....Mann M. (Nature 2003)
Novel tumor antigens identified by autologous antibody screening of childhood medulloblastoma cDNA libraries. (PubMed id 12800201)^{1, 2} Behrends U.... Mautner J. (Int. J. Cancer 2003)
Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PubMed id 9455484)^{1, 2} Seki N.... Ohara O. (DNA Res. 1997)
beta-Catenin is a Nek2 substrate involved in centrosome separation. (PubMed id 18086858)^{1, 9} Bahmanyar S....Barth A.I. (Genes Dev. 2008)
Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)¹ Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
The functional interactome landscape of the human histone deacetylase family. (PubMed id 23752268)¹ Joshi P....Cristea I.M. (Mol. Syst. Biol. 2013)

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Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 9696	HGNC: 21299	AceView: CROCC	Ensembl:ENSG00000058453	euGenes: HUgn9696
ECgene: CROCC	H-InvDB: CROCC

(According to HUGE)
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HUGE: KIAA0445

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CROCC	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CROCC gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CROCC gene:
Search GeneIP for patents involving CROCC

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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CROCC Gene

Ciliary Rootlet Coiled-Coil, Rootletin

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CROCC Gene

Ciliary Rootlet Coiled-Coil, Rootletin

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