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CROCC Gene(Protein Coding)

Ciliary Rootlet Coiled-Coil, Rootletin

GCID:
GC01P016748
GIFtS:
47
Genes Participants
UDN Logo

Aliases for CROCC Gene

Aliases for CROCC Gene

  • Ciliary Rootlet Coiled-Coil, Rootletin 2 3 5
  • Ciliary Rootlet Coiled-Coil Protein 3 4
  • Rootletin, Ciliary Rootlet Protein 3
  • Ciliary Rootlet Protein 2
  • Tax1-Binding Protein 2 3
  • Rootletin 2
  • KIAA0445 4
  • ROLT 3

External Ids for CROCC Gene

Previous GeneCards Identifiers for CROCC Gene

  • GC01P016201
  • GC01P016631
  • GC01P016993
  • GC01P017121
  • GC01P017049
  • GC01P017223
  • GC01P015492
  • GC01P017093
  • GC01P017099
  • GC01P016741
  • GC01P016745

Summaries for CROCC Gene

GeneCards Summary for CROCC Gene

CROCC (Ciliary Rootlet Coiled-Coil, Rootletin) is a Protein Coding gene. GO annotations related to this gene include structural molecule activity and kinesin binding. An important paralog of this gene is CROCC2.

UniProtKB/Swiss-Prot for CROCC Gene

  • Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus. Contributes to centrosome cohesion before mitosis.

Gene Wiki entry for CROCC Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CROCC Gene

Genomics for CROCC Gene

Products:

  1. Regulatory Element

Regulatory Elements for CROCC Gene

Enhancers for CROCC Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CROCC on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the CROCC gene promoter:

Genomic Location for CROCC Gene

Chromosome:
1
Start:
16,740,273 bp from pter
End:
16,972,979 bp from pter
Size:
232,707 bases
Orientation:
Plus strand

Genomic View for CROCC Gene

Genes around CROCC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CROCC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CROCC Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CROCC Gene

Proteins for CROCC Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CROCC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TZA2-CROCC_HUMAN
    Recommended name:
    Rootletin
    Protein Accession:
    Q5TZA2
    Secondary Accessions:
    • Q2VHY3
    • Q66GT7
    • Q7Z2L4
    • Q7Z5D7

    Protein attributes for CROCC Gene

    Size:
    2017 amino acids
    Molecular mass:
    228523 Da
    Quaternary structure:
    • Homopolymer. Interacts with KLC3, NEK2 and the N-terminus of CEP250.

    Alternative splice isoforms for CROCC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CROCC Gene

Proteomics data for CROCC Gene at MOPED

Protein Expression for CROCC Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CROCC Gene

  • Phosphorylated by NEK2 which may regulate its association with centrosomes.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CROCC Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CROCC Gene

Domains & Families for CROCC Gene

Protein Domains for CROCC Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CROCC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5TZA2

UniProtKB/Swiss-Prot:

CROCC_HUMAN :
  • Belongs to the rootletin family.
Family:
  • Belongs to the rootletin family.
genes like me logo Genes that share domains with CROCC: view

No data available for Gene Families for CROCC Gene

Function for CROCC Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for CROCC Gene

UniProtKB/Swiss-Prot Function:
Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus. Contributes to centrosome cohesion before mitosis.

Gene Ontology (GO) - Molecular Function for CROCC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005198 structural molecule activity IEA,ISS --
genes like me logo Genes that share ontologies with CROCC: view

Phenotypes for CROCC Gene

MGI mutant phenotypes for CROCC:
inferred from 1 alleles
GenomeRNAi human phenotypes for CROCC:
genes like me logo Genes that share phenotypes with CROCC: view

Animal Models for CROCC Gene

MGI Knock Outs for CROCC:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CROCC Gene

Localization for CROCC Gene

Subcellular locations from UniProtKB/Swiss-Prot for CROCC Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=In ciliated cells, associated with ciliary rootlets. In non-ciliated cells, localized between, around and at the proximal ends of the centrioles. Dissociates from the centrioles at the onset of mitosis and reassociates with them at anaphase.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CROCC Gene COMPARTMENTS Subcellular localization image for CROCC gene
Compartment Confidence
cytoskeleton 5
extracellular 5
plasma membrane 5
cytosol 3
nucleus 3

Gene Ontology (GO) - Cellular Components for CROCC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0015629 actin cytoskeleton IDA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with CROCC: view

Pathways & Interactions for CROCC Gene

SuperPathways for CROCC Gene

PathCards logoMore details on SuperPathways for CROCC
No Data Available

SIGNOR curated interactions for CROCC Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for CROCC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010457 centriole-centriole cohesion IMP 24554434
GO:0033365 protein localization to organelle IMP 24554434
GO:0045494 photoreceptor cell maintenance IEA --
GO:0051297 centrosome organization IEA,IDA 16203858
genes like me logo Genes that share ontologies with CROCC: view

No data available for Pathways by source for CROCC Gene

Drugs & Compounds for CROCC Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for CROCC Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for CROCC Gene

(7) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(72) Selected AceView cDNA sequences:
(13) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CROCC Gene

Ciliary rootlet coiled-coil, rootletin:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CROCC Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18a · 18b ^ 19 ^ 20a ·
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

ExUns: 20b ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26a · 26b · 26c ^ 27a · 27b · 27c · 27d
SP1: - - -
SP2: -
SP3:
SP4:
SP5: - - - - - - -
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for CROCC Gene

GeneLoc Exon Structure for
CROCC
ECgene alternative splicing isoforms for
CROCC

Expression for CROCC Gene

Products:

  1. Primer

mRNA expression in normal human tissues for CROCC Gene

mRNA expression in normal human tissues for CROCC Gene
mRNA expression by BioGPS for CROCC GenemRNA expression by GTEx for CROCC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CROCC Gene

This gene is overexpressed in Neutrophil (11.9), Retina (9.2), and Lymph node (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for CROCC Gene



SOURCE GeneReport for Unigene cluster for CROCC Gene Hs.309403

genes like me logo Genes that share expression patterns with CROCC: view

Protein tissue co-expression partners for CROCC Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CROCC Gene

Orthologs for CROCC Gene

This gene was present in the common ancestor of animals.

Orthologs for CROCC Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia CROCC 35
  • 86.29 (n)
  • 84.22 (a)
CROCC 36
  • 83 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia CROCC 35
  • 88.06 (n)
  • 87.57 (a)
CROCC 36
  • 86 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Crocc 35
  • 83.45 (n)
  • 83.05 (a)
Crocc 16
Crocc 36
  • 83 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia CROCC 35
  • 98.91 (n)
  • 98.96 (a)
CROCC 36
  • 99 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Crocc 35
  • 83.35 (n)
  • 84.18 (a)
oppossum
(Monodelphis domestica)
 Mammalia CROCC 36
  • 58 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia CROCC 36
  • 70 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves CROCC 35
  • 63.2 (n)
  • 51.72 (a)
CROCC 36
  • 45 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia -- 36
  • 55 (a)
 OneToMany
-- 36
  • 48 (a)
 OneToMany
tropical clawed frog
(Silurana tropicalis)
 Amphibia LOC100498193 35
  • 52.91 (n)
  • 44.76 (a)
zebrafish
(Danio rerio)
 Actinopterygii LOC101885282 35
  • 50.49 (n)
  • 41.15 (a)
CABZ01072698.1 36
  • 30 (a)
 ManyToMany
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP003449 35
  • 45.26 (n)
  • 32.51 (a)
fruit fly
(Drosophila melanogaster)
 Insecta Rootletin 35
  • 60.42 (n)
  • 51.56 (a)
Rootletin 36
  • 24 (a)
 OneToMany
sea squirt
(Ciona intestinalis)
 Ascidiacea Cin.5391 35
Species with no ortholog for CROCC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CROCC Gene

ENSEMBL:
Gene Tree for CROCC (if available)
TreeFam:
Gene Tree for CROCC (if available)

Paralogs for CROCC Gene

Paralogs for CROCC Gene

(4) SIMAP similar genes for CROCC Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for CROCC Gene

genes like me logo Genes that share paralogs with CROCC: view

Variants for CROCC Gene

Sequence variations from dbSNP and Humsavar for CROCC Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs4463721 - 16,938,425(-) GGGCC(A/G)CCTGC reference, missense
rs9435714 - 16,940,041(+) ACGAG(C/G/T)ACGCC reference, missense
rs6669627 - 16,954,326(+) GAAAC(C/G)AGATG reference, missense
rs6586566 - 16,922,037(+) TGGCG(A/G)GGGCA intron-variant, reference, missense
rs57442576 - 16,936,795(+) GCTGC(A/G)GGACA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CROCC Gene

Variant ID Type Subtype PubMed ID
dgv29e1 CNV Complex 17122850
nsv428421 CNV Gain+Loss 18775914
nsv9324 CNV Gain+Loss 18304495
dgv30e1 CNV Complex 17122850
nsv829625 CNV Gain 20364138
nsv7173 OTHER Inversion 18451855
dgv34e1 CNV Complex 17122850
esv29948 CNV Loss 18421352
dgv178n71 CNV Gain 21882294
dgv40e1 CNV Complex 17122850
esv33965 CNV Gain+Loss 17666407
dgv41e1 CNV Complex 17122850
esv26111 CNV Gain+Loss 19812545
nsv821037 CNV Duplication 20802225
nsv834258 CNV Loss 17160897
nsv834269 CNV Loss 17160897
esv990069 CNV Loss 20482838
nsv442727 CNV CNV 18776908
dgv180n71 CNV Loss 21882294
dgv23n67 CNV Gain 20364138
nsv433184 CNV Loss 18776910
dgv181n71 CNV Gain 21882294
dgv182n71 CNV Gain+Loss 21882294
esv29988 CNV Loss 17803354
esv2421455 CNV Duplication 20811451
nsv834280 CNV Loss 17160897
essv24221 CNV CNV 17122850
nsv437207 CNV Loss 16327808
dgv24n67 CNV Gain 20364138
dgv183n71 CNV Loss 21882294
dgv25n67 CNV Gain 20364138
nsv508947 CNV Insertion 20534489
dgv184n71 CNV Loss 21882294
nsv482201 CNV Gain 20164927
nsv437208 CNV Loss 16327808
nsv438355 CNV Loss 16468122
nsv471438 CNV Duplication 19718026
dgv185n71 CNV Loss 21882294
nsv871590 CNV Loss 21882294

Variation tolerance for CROCC Gene

Residual Variation Intolerance Score: 99.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.05; 93.77% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CROCC Gene

Disorders for CROCC Gene

Relevant External Links for CROCC

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CROCC

No disorders were found for CROCC Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CROCC Gene

Publications for CROCC Gene

  1. Rootletin forms centriole-associated filaments and functions in centrosome cohesion. (PMID: 16203858) Bahe S. … Nigg E.A. (J. Cell Biol. 2005) 3 4 23 67
  2. Rootletin, a novel coiled-coil protein, is a structural component of the ciliary rootlet. (PMID: 12427867) Yang J. … Li T. (J. Cell Biol. 2002) 2 3 23
  3. Tissue expression patterns identify mouse cilia genes. (PMID: 17971504) McClintock T.S. … Bergman D.A. (Physiol. Genomics 2008) 2 3
  4. beta-Catenin is a Nek2 substrate involved in centrosome separation. (PMID: 18086858) Bahmanyar S. … Barth A.I. (Genes Dev. 2008) 3 23
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for CROCC Gene

  • Addgene plasmids for CROCC

Sources for CROCC Gene

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